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Hoshi, Naoto

TitleAssociate Professor
InstitutionUniversity of California, Irvine
DepartmentPharmacology
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-0969, 0970
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulations and function of the M-channel
    NIH/NINDS R01NS067288Jan 15, 2010 - Nov 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Greene DL, Kang S, Hoshi N. XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits. J Pharmacol Exp Ther. 2017 Jul; 362(1):177-185. PMID: 28483800.
      View in: PubMed
    2. Greene DL, Hoshi N. Modulation of Kv7 channels and excitability in the brain. Cell Mol Life Sci. 2017 02; 74(3):495-508. PMID: 27645822.
      View in: PubMed
    3. Jiang L, Kosenko A, Yu C, Huang L, Li X, Hoshi N. Activation of m1 muscarinic acetylcholine receptor induces surface transport of KCNQ channels through a CRMP-2-mediated pathway. J Cell Sci. 2015 Nov 15; 128(22):4235-45. PMID: 26446259; PMCID: PMC4712786 [Available on 11/15/16].
    4. Kay HY, Greene DL, Kang S, Kosenko A, Hoshi N. M-current preservation contributes to anticonvulsant effects of valproic acid. J Clin Invest. 2015 Oct 01; 125(10):3904-14. PMID: 26348896; PMCID: PMC4607138.
    5. Kang S, Xu M, Cooper EC, Hoshi N. Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. J Biol Chem. 2014 Apr 18; 289(16):11536-44. PMID: 24627475; PMCID: PMC4036288.
    6. Kosenko A, Hoshi N. A change in configuration of the calmodulin-KCNQ channel complex underlies Ca2+-dependent modulation of KCNQ channel activity. PLoS One. 2013; 8(12):e82290. PMID: 24349250; PMCID: PMC3857245.
    7. Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL, Chandy KG. Modulation of voltage-gated K+ channels by the sodium channel ß1 subunit. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18577-82. PMID: 23090990; PMCID: PMC3494885.
    8. Kosenko A, Kang S, Smith IM, Greene DL, Langeberg LK, Scott JD, Hoshi N. Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. EMBO J. 2012 May 29; 31(14):3147-56. PMID: 22643219; PMCID: PMC3400014.
    9. Greene D, Kang S, Kosenko A, Hoshi N. Adrenergic regulation of HCN4 channel requires protein association with ß2-adrenergic receptor. J Biol Chem. 2012 Jul 06; 287(28):23690-7. PMID: 22613709; PMCID: PMC3390643.
    10. Smith IM, Hoshi N. ATP competitive protein kinase C inhibitors demonstrate distinct state-dependent inhibition. PLoS One. 2011; 6(10):e26338. PMID: 22043317; PMCID: PMC3197134.
    11. Hoshi N, Langeberg LK, Gould CM, Newton AC, Scott JD. Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell. 2010 Feb 26; 37(4):541-50. PMID: 20188672; PMCID: PMC3014287.
    12. Tunquist BJ, Hoshi N, Guire ES, Zhang F, Mullendorff K, Langeberg LK, Raber J, Scott JD. Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12557-62. PMID: 18711127; PMCID: PMC2527950.
    13. Saneyoshi T, Wayman G, Fortin D, Davare M, Hoshi N, Nozaki N, Natsume T, Soderling TR. Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Neuron. 2008 Jan 10; 57(1):94-107. PMID: 18184567; PMCID: PMC2277504.
    14. Higashida H, Bowden SE, Yokoyama S, Salmina A, Hashii M, Hoshi N, Zhang JS, Knijnik R, Noda M, Zhong ZG, Jin D, Higashida K, Takeda H, Akita T, Kuba K, Yamagishi S, Shimizu N, Takasawa S, Okamoto H, Robbins J. Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells. Neurosci Res. 2007 Mar; 57(3):339-46. PMID: 17173996.
      View in: PubMed
    15. Gold MG, Lygren B, Dokurno P, Hoshi N, McConnachie G, Taskén K, Carlson CR, Scott JD, Barford D. Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell. 2006 Nov 03; 24(3):383-95. PMID: 17081989.
      View in: PubMed
    16. Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD. Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell. 2006 Sep 15; 23(6):925-31. PMID: 16973443; PMCID: PMC3941446.
    17. Carlson CR, Lygren B, Berge T, Hoshi N, Wong W, Taskén K, Scott JD. Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J Biol Chem. 2006 Jul 28; 281(30):21535-45. PMID: 16728392.
      View in: PubMed
    18. Hoshi N, Scott JD. Contextual utilization of enzymes in discrete AKAP79/150 signalling complexes. Eur J Cell Biol. 2006 Jul; 85(7):621-2. PMID: 16460836.
      View in: PubMed
    19. Hoshi N, Langeberg LK, Scott JD. Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Nat Cell Biol. 2005 Nov; 7(11):1066-73. PMID: 16228013; PMCID: PMC3923410.
    20. Yamaguchi M, Shimizu M, Ino H, Terai H, Hayashi K, Kaneda T, Mabuchi H, Sumita R, Oshima T, Hoshi N, Higashida H. Compound heterozygosity for mutations Asp611-->Tyr in KCNQ1 and Asp609-->Gly in KCNH2 associated with severe long QT syndrome. Clin Sci (Lond). 2005 Feb; 108(2):143-50. PMID: 15500450.
      View in: PubMed
    21. Higashida H, Hoshi N, Zhang JS, Yokoyama S, Hashii M, Jin D, Noda M, Robbins J. Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels. Neurosci Res. 2005 Mar; 51(3):231-4. PMID: 15710486.
      View in: PubMed
    22. Hayashi K, Shimizu M, Ino H, Yamaguchi M, Terai H, Hoshi N, Higashida H, Terashima N, Uno Y, Kanaya H, Mabuchi H. Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG. Clin Sci (Lond). 2004 Aug; 107(2):175-82. PMID: 15043509.
      View in: PubMed
    23. Higashida H, Zhang JS, Mochida S, Chen XL, Shin Y, Noda M, Hossain KZ, Hoshi N, Hashii M, Shigemoto R, Nakanishi S, Fukuda Y, Yokoyama S. Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. J Neurochem. 2003 Jun; 85(5):1148-58. PMID: 12753074.
      View in: PubMed
    24. Hoshi N, Zhang JS, Omaki M, Takeuchi T, Yokoyama S, Wanaverbecq N, Langeberg LK, Yoneda Y, Scott JD, Brown DA, Higashida H. AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci. 2003 Jun; 6(6):564-71. PMID: 12754513; PMCID: PMC3941299.
    25. Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD. Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4445-50. PMID: 12672969; PMCID: PMC153575.
    26. Yamaguchi M, Shimizu M, Ino H, Terai H, Hayashi K, Mabuchi H, Hoshi N, Higashida H. Clinical and electrophysiological characterization of a novel mutation (F193L) in the KCNQ1 gene associated with long QT syndrome. Clin Sci (Lond). 2003 Apr; 104(4):377-82. PMID: 12653681.
      View in: PubMed
    27. Masuda H, Kawamura K, Nanjo H, Sho E, Komatsu M, Sugiyama T, Sugita A, Asari Y, Kobayashi M, Ebina T, Hoshi N, Singh TM, Xu C, Zarins CK. Ultrastructure of endothelial cells under flow alteration. Microsc Res Tech. 2003 Jan 01; 60(1):2-12. PMID: 12500255.
      View in: PubMed
    28. Ebina T, Hoshi N, Kobayashi M, Kawamura K, Nanjo H, Sugita A, Sugiyama T, Masuda H, Xu C. Physiological angiogenesis in electrically stimulated skeletal muscle in rabbits: characterization of capillary sprouting by ultrastructural 3-D reconstruction study. Pathol Int. 2002 Nov; 52(11):702-12. PMID: 12685547.
      View in: PubMed
    29. Hayashi K, Shimizu M, Ino H, Yamaguchi M, Mabuchi H, Hoshi N, Higashida H. Characterization of a novel missense mutation E637K in the pore-S6 loop of HERG in a patient with long QT syndrome. Cardiovasc Res. 2002 Apr; 54(1):67-76. PMID: 12062363.
      View in: PubMed
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