Naoto Hoshi

Title(s)Associate Professor, Pharmaceutical Sciences
SchoolSchool of Pharmacy and Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-0969, 0970
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    Collapse Research 
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    Regulations and function of the M-channel
    NIH R01NS067288Jan 15, 2010 - Nov 30, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dehydroepiandrosterone Sulfate (DHEAS) Is an Endogenous Kv7 Channel Modulator That Reduces Kv7/M-Current Suppression and Inflammatory Pain. J Neurosci. 2023 10 25; 43(43):7073-7083. Alhassen L, Alhassen W, Wong C, Sun Y, Xia Z, Civelli O, Hoshi N. PMID: 37648450; PMCID: PMC10601364.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Clinical Comparison of Unilateral Biportal Endoscopic Laminectomy versus Microendoscopic Laminectomy for Single-Level Laminectomy: A Single-Center, Retrospective Analysis. World Neurosurg. 2021 04; 148:e581-e588. Ito Z, Shibayama M, Nakamura S, Yamada M, Kawai M, Takeuchi M, Yoshimatsu H, Kuraishi K, Hoshi N, Miura Y, Ito F. PMID: 33476779.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    3. Hydrogen Sulfide Relaxes Human Uterine Artery via Activating Smooth Muscle BKCa Channels. Antioxidants (Basel). 2020 Nov 13; 9(11). Li Y, Bai J, Yang YH, Hoshi N, Chen DB. PMID: 33202933; PMCID: PMC7697977.
      View in: PubMed   Mentions: 13  
    4. Postoperative Outcomes After Transsacral Epiduroscopic Laser Decompression in Japanese Patients: Denervation Therapy for Discogenic Low-Back Pain. Photobiomodul Photomed Laser Surg. 2020 Aug; 38(8):507-511. Ito Z, Shibayama M, Nakamura S, Yamada M, Kawai M, Shimizu K, Takuechi M, Yoshimatsu H, Kuraishi K, Hoshi N, Taguchi M, Miura Y, Ito F. PMID: 32780687.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. In Vivo Attenuation of M-Current Suppression Impairs Consolidation of Object Recognition Memory. J Neurosci. 2020 07 22; 40(30):5847-5856. Kosenko A, Moftakhar S, Wood MA, Hoshi N. PMID: 32554550; PMCID: PMC7380971.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. M-Current Suppression, Seizures and Lipid Metabolism: A Potential Link Between Neuronal Kv7 Channel Regulation and Dietary Therapies for Epilepsy. Front Physiol. 2020; 11:513. Hoshi N. PMID: 32523549; PMCID: PMC7261926.
      View in: PubMed   Mentions: 2  
    7. Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins. Proc Natl Acad Sci U S A. 2018 12 04; 115(49):E11465-E11474. Smith FD, Omar MH, Nygren PJ, Soughayer J, Hoshi N, Lau HT, Snyder CG, Branon TC, Ghosh D, Langeberg LK, Ting AY, Santana LF, Ong SE, Navedo MF, Scott JD. PMID: 30455320; PMCID: PMC6298107.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    8. Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden and prevents status epilepticus-induced neuronal death and epileptogenesis. Epilepsia. 2018 10; 59(10):1908-1918. Greene DL, Kosenko A, Hoshi N. PMID: 30146722; PMCID: PMC6204291.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    9. XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits. J Pharmacol Exp Ther. 2017 07; 362(1):177-185. Greene DL, Kang S, Hoshi N. PMID: 28483800; PMCID: PMC5478917.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    10. Modulation of Kv7 channels and excitability in the brain. Cell Mol Life Sci. 2017 02; 74(3):495-508. Greene DL, Hoshi N. PMID: 27645822; PMCID: PMC5243414.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    11. Activation of m1 muscarinic acetylcholine receptor induces surface transport of KCNQ channels through a CRMP-2-mediated pathway. J Cell Sci. 2015 Nov 15; 128(22):4235-45. Jiang L, Kosenko A, Yu C, Huang L, Li X, Hoshi N. PMID: 26446259; PMCID: PMC4712786.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. M-current preservation contributes to anticonvulsant effects of valproic acid. J Clin Invest. 2015 Oct 01; 125(10):3904-14. Kay HY, Greene DL, Kang S, Kosenko A, Hoshi N. PMID: 26348896; PMCID: PMC4607138.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    13. Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. J Biol Chem. 2014 Apr 18; 289(16):11536-11544. Kang S, Xu M, Cooper EC, Hoshi N. PMID: 24627475; PMCID: PMC4036288.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    14. A change in configuration of the calmodulin-KCNQ channel complex underlies Ca2+-dependent modulation of KCNQ channel activity. PLoS One. 2013; 8(12):e82290. Kosenko A, Hoshi N. PMID: 24349250; PMCID: PMC3857245.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    15. Modulation of voltage-gated K+ channels by the sodium channel β1 subunit. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18577-82. Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL, Chandy KG. PMID: 23090990; PMCID: PMC3494885.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    16. Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. EMBO J. 2012 May 29; 31(14):3147-56. Kosenko A, Kang S, Smith IM, Greene DL, Langeberg LK, Scott JD, Hoshi N. PMID: 22643219; PMCID: PMC3400014.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    17. Adrenergic regulation of HCN4 channel requires protein association with β2-adrenergic receptor. J Biol Chem. 2012 Jul 06; 287(28):23690-7. Greene D, Kang S, Kosenko A, Hoshi N. PMID: 22613709; PMCID: PMC3390643.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. ATP competitive protein kinase C inhibitors demonstrate distinct state-dependent inhibition. PLoS One. 2011; 6(10):e26338. Smith IM, Hoshi N. PMID: 22043317; PMCID: PMC3197134.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    19. Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell. 2010 Feb 26; 37(4):541-50. Hoshi N, Langeberg LK, Gould CM, Newton AC, Scott JD. PMID: 20188672; PMCID: PMC3014287.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    20. Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12557-62. Tunquist BJ, Hoshi N, Guire ES, Zhang F, Mullendorff K, Langeberg LK, Raber J, Scott JD. PMID: 18711127; PMCID: PMC2527950.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    21. Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Neuron. 2008 Jan 10; 57(1):94-107. Saneyoshi T, Wayman G, Fortin D, Davare M, Hoshi N, Nozaki N, Natsume T, Soderling TR. PMID: 18184567; PMCID: PMC2277504.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    22. Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells. Neurosci Res. 2007 Mar; 57(3):339-46. Higashida H, Bowden SE, Yokoyama S, Salmina A, Hashii M, Hoshi N, Zhang JS, Knijnik R, Noda M, Zhong ZG, Jin D, Higashida K, Takeda H, Akita T, Kuba K, Yamagishi S, Shimizu N, Takasawa S, Okamoto H, Robbins J. PMID: 17173996.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    23. Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell. 2006 Nov 03; 24(3):383-95. Gold MG, Lygren B, Dokurno P, Hoshi N, McConnachie G, Taskén K, Carlson CR, Scott JD, Barford D. PMID: 17081989.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    24. Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell. 2006 Sep 15; 23(6):925-31. Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD. PMID: 16973443; PMCID: PMC3941446.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    25. Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J Biol Chem. 2006 Jul 28; 281(30):21535-21545. Carlson CR, Lygren B, Berge T, Hoshi N, Wong W, Taskén K, Scott JD. PMID: 16728392.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    26. Contextual utilization of enzymes in discrete AKAP79/150 signalling complexes. Eur J Cell Biol. 2006 Jul; 85(7):621-2. Hoshi N, Scott JD. PMID: 16460836.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    27. Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Nat Cell Biol. 2005 Nov; 7(11):1066-73. Hoshi N, Langeberg LK, Scott JD. PMID: 16228013; PMCID: PMC3923410.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    28. Compound heterozygosity for mutations Asp611-->Tyr in KCNQ1 and Asp609-->Gly in KCNH2 associated with severe long QT syndrome. Clin Sci (Lond). 2005 Feb; 108(2):143-50. Yamaguchi M, Shimizu M, Ino H, Terai H, Hayashi K, Kaneda T, Mabuchi H, Sumita R, Oshima T, Hoshi N, Higashida H. PMID: 15500450.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels. Neurosci Res. 2005 Mar; 51(3):231-4. Higashida H, Hoshi N, Zhang JS, Yokoyama S, Hashii M, Jin D, Noda M, Robbins J. PMID: 15710486.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    30. Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG. Clin Sci (Lond). 2004 Aug; 107(2):175-82. Hayashi K, Shimizu M, Ino H, Yamaguchi M, Terai H, Hoshi N, Higashida H, Terashima N, Uno Y, Kanaya H, Mabuchi H. PMID: 15043509.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    31. AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci. 2003 Jun; 6(6):564-71. Hoshi N, Zhang JS, Omaki M, Takeuchi T, Yokoyama S, Wanaverbecq N, Langeberg LK, Yoneda Y, Scott JD, Brown DA, Higashida H. PMID: 12754513; PMCID: PMC3941299.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    32. Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. J Neurochem. 2003 Jun; 85(5):1148-58. Higashida H, Zhang JS, Mochida S, Chen XL, Shin Y, Noda M, Hossain KZ, Hoshi N, Hashii M, Shigemoto R, Nakanishi S, Fukuda Y, Yokoyama S. PMID: 12753074.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    33. Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4445-50. Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD. PMID: 12672969; PMCID: PMC153575.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    34. Clinical and electrophysiological characterization of a novel mutation (F193L) in the KCNQ1 gene associated with long QT syndrome. Clin Sci (Lond). 2003 Apr; 104(4):377-82. Yamaguchi M, Shimizu M, Ino H, Terai H, Hayashi K, Mabuchi H, Hoshi N, Higashida H. PMID: 12653681.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    35. Ultrastructure of endothelial cells under flow alteration. Microsc Res Tech. 2003 Jan 01; 60(1):2-12. Masuda H, Kawamura K, Nanjo H, Sho E, Komatsu M, Sugiyama T, Sugita A, Asari Y, Kobayashi M, Ebina T, Hoshi N, Singh TM, Xu C, Zarins CK. PMID: 12500255.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    36. Physiological angiogenesis in electrically stimulated skeletal muscle in rabbits: characterization of capillary sprouting by ultrastructural 3-D reconstruction study. Pathol Int. 2002 Nov; 52(11):702-12. Ebina T, Hoshi N, Kobayashi M, Kawamura K, Nanjo H, Sugita A, Sugiyama T, Masuda H, Xu C. PMID: 12685547.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
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