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Dehydroepiandrosterone Sulfate (DHEAS) Is an Endogenous Kv7 Channel Modulator That Reduces Kv7/M-Current Suppression and Inflammatory Pain. J Neurosci. 2023 10 25; 43(43):7073-7083.
Alhassen L, Alhassen W, Wong C, Sun Y, Xia Z, Civelli O, Hoshi N. PMID: 37648450; PMCID: PMC10601364.
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Animals
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Clinical Comparison of Unilateral Biportal Endoscopic Laminectomy versus Microendoscopic Laminectomy for Single-Level Laminectomy: A Single-Center, Retrospective Analysis. World Neurosurg. 2021 04; 148:e581-e588.
Ito Z, Shibayama M, Nakamura S, Yamada M, Kawai M, Takeuchi M, Yoshimatsu H, Kuraishi K, Hoshi N, Miura Y, Ito F. PMID: 33476779.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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Hydrogen Sulfide Relaxes Human Uterine Artery via Activating Smooth Muscle BKCa Channels. Antioxidants (Basel). 2020 Nov 13; 9(11).
Li Y, Bai J, Yang YH, Hoshi N, Chen DB. PMID: 33202933; PMCID: PMC7697977.
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13
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Postoperative Outcomes After Transsacral Epiduroscopic Laser Decompression in Japanese Patients: Denervation Therapy for Discogenic Low-Back Pain. Photobiomodul Photomed Laser Surg. 2020 Aug; 38(8):507-511.
Ito Z, Shibayama M, Nakamura S, Yamada M, Kawai M, Shimizu K, Takuechi M, Yoshimatsu H, Kuraishi K, Hoshi N, Taguchi M, Miura Y, Ito F. PMID: 32780687.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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In Vivo Attenuation of M-Current Suppression Impairs Consolidation of Object Recognition Memory. J Neurosci. 2020 07 22; 40(30):5847-5856.
Kosenko A, Moftakhar S, Wood MA, Hoshi N. PMID: 32554550; PMCID: PMC7380971.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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M-Current Suppression, Seizures and Lipid Metabolism: A Potential Link Between Neuronal Kv7 Channel Regulation and Dietary Therapies for Epilepsy. Front Physiol. 2020; 11:513.
Hoshi N. PMID: 32523549; PMCID: PMC7261926.
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2
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Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins. Proc Natl Acad Sci U S A. 2018 12 04; 115(49):E11465-E11474.
Smith FD, Omar MH, Nygren PJ, Soughayer J, Hoshi N, Lau HT, Snyder CG, Branon TC, Ghosh D, Langeberg LK, Ting AY, Santana LF, Ong SE, Navedo MF, Scott JD. PMID: 30455320; PMCID: PMC6298107.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden and prevents status epilepticus-induced neuronal death and epileptogenesis. Epilepsia. 2018 10; 59(10):1908-1918.
Greene DL, Kosenko A, Hoshi N. PMID: 30146722; PMCID: PMC6204291.
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13 Fields:
Translation:
AnimalsCells
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XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits. J Pharmacol Exp Ther. 2017 07; 362(1):177-185.
Greene DL, Kang S, Hoshi N. PMID: 28483800; PMCID: PMC5478917.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Modulation of Kv7 channels and excitability in the brain. Cell Mol Life Sci. 2017 02; 74(3):495-508.
Greene DL, Hoshi N. PMID: 27645822; PMCID: PMC5243414.
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PubMed Mentions:
69 Fields:
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HumansAnimalsCells
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Activation of m1 muscarinic acetylcholine receptor induces surface transport of KCNQ channels through a CRMP-2-mediated pathway. J Cell Sci. 2015 Nov 15; 128(22):4235-45.
Jiang L, Kosenko A, Yu C, Huang L, Li X, Hoshi N. PMID: 26446259; PMCID: PMC4712786.
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PubMed Mentions:
5 Fields:
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HumansAnimalsCells
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M-current preservation contributes to anticonvulsant effects of valproic acid. J Clin Invest. 2015 Oct 01; 125(10):3904-14.
Kay HY, Greene DL, Kang S, Kosenko A, Hoshi N. PMID: 26348896; PMCID: PMC4607138.
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PubMed Mentions:
24 Fields:
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HumansAnimalsCells
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Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. J Biol Chem. 2014 Apr 18; 289(16):11536-11544.
Kang S, Xu M, Cooper EC, Hoshi N. PMID: 24627475; PMCID: PMC4036288.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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A change in configuration of the calmodulin-KCNQ channel complex underlies Ca2+-dependent modulation of KCNQ channel activity. PLoS One. 2013; 8(12):e82290.
Kosenko A, Hoshi N. PMID: 24349250; PMCID: PMC3857245.
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37 Fields:
Translation:
HumansAnimalsCells
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Modulation of voltage-gated K+ channels by the sodium channel β1 subunit. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18577-82.
Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL, Chandy KG. PMID: 23090990; PMCID: PMC3494885.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. EMBO J. 2012 May 29; 31(14):3147-56.
Kosenko A, Kang S, Smith IM, Greene DL, Langeberg LK, Scott JD, Hoshi N. PMID: 22643219; PMCID: PMC3400014.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Adrenergic regulation of HCN4 channel requires protein association with β2-adrenergic receptor. J Biol Chem. 2012 Jul 06; 287(28):23690-7.
Greene D, Kang S, Kosenko A, Hoshi N. PMID: 22613709; PMCID: PMC3390643.
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PubMed Mentions:
9 Fields:
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HumansAnimalsCells
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ATP competitive protein kinase C inhibitors demonstrate distinct state-dependent inhibition. PLoS One. 2011; 6(10):e26338.
Smith IM, Hoshi N. PMID: 22043317; PMCID: PMC3197134.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell. 2010 Feb 26; 37(4):541-50.
Hoshi N, Langeberg LK, Gould CM, Newton AC, Scott JD. PMID: 20188672; PMCID: PMC3014287.
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PubMed Mentions:
73 Fields:
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AnimalsCells
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Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12557-62.
Tunquist BJ, Hoshi N, Guire ES, Zhang F, Mullendorff K, Langeberg LK, Raber J, Scott JD. PMID: 18711127; PMCID: PMC2527950.
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PubMed Mentions:
95 Fields:
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AnimalsCells
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Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Neuron. 2008 Jan 10; 57(1):94-107.
Saneyoshi T, Wayman G, Fortin D, Davare M, Hoshi N, Nozaki N, Natsume T, Soderling TR. PMID: 18184567; PMCID: PMC2277504.
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PubMed Mentions:
119 Fields:
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HumansAnimalsCells
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Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells. Neurosci Res. 2007 Mar; 57(3):339-46.
Higashida H, Bowden SE, Yokoyama S, Salmina A, Hashii M, Hoshi N, Zhang JS, Knijnik R, Noda M, Zhong ZG, Jin D, Higashida K, Takeda H, Akita T, Kuba K, Yamagishi S, Shimizu N, Takasawa S, Okamoto H, Robbins J. PMID: 17173996.
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PubMed Mentions:
8 Fields:
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HumansAnimalsCells
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Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell. 2006 Nov 03; 24(3):383-95.
Gold MG, Lygren B, Dokurno P, Hoshi N, McConnachie G, Taskén K, Carlson CR, Scott JD, Barford D. PMID: 17081989.
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PubMed Mentions:
140 Fields:
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HumansAnimalsCells
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Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell. 2006 Sep 15; 23(6):925-31.
Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD. PMID: 16973443; PMCID: PMC3941446.
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PubMed Mentions:
122 Fields:
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HumansCells
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Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J Biol Chem. 2006 Jul 28; 281(30):21535-21545.
Carlson CR, Lygren B, Berge T, Hoshi N, Wong W, Taskén K, Scott JD. PMID: 16728392.
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69 Fields:
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HumansAnimalsCells
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Contextual utilization of enzymes in discrete AKAP79/150 signalling complexes. Eur J Cell Biol. 2006 Jul; 85(7):621-2.
Hoshi N, Scott JD. PMID: 16460836.
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PubMed Mentions:
1 Fields:
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AnimalsCells
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Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Nat Cell Biol. 2005 Nov; 7(11):1066-73.
Hoshi N, Langeberg LK, Scott JD. PMID: 16228013; PMCID: PMC3923410.
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PubMed Mentions:
104 Fields:
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HumansCells
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Compound heterozygosity for mutations Asp611-->Tyr in KCNQ1 and Asp609-->Gly in KCNH2 associated with severe long QT syndrome. Clin Sci (Lond). 2005 Feb; 108(2):143-50.
Yamaguchi M, Shimizu M, Ino H, Terai H, Hayashi K, Kaneda T, Mabuchi H, Sumita R, Oshima T, Hoshi N, Higashida H. PMID: 15500450.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels. Neurosci Res. 2005 Mar; 51(3):231-4.
Higashida H, Hoshi N, Zhang JS, Yokoyama S, Hashii M, Jin D, Noda M, Robbins J. PMID: 15710486.
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PubMed Mentions:
17 Fields:
Translation:
Animals
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Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG. Clin Sci (Lond). 2004 Aug; 107(2):175-82.
Hayashi K, Shimizu M, Ino H, Yamaguchi M, Terai H, Hoshi N, Higashida H, Terashima N, Uno Y, Kanaya H, Mabuchi H. PMID: 15043509.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. J Neurochem. 2003 Jun; 85(5):1148-58.
Higashida H, Zhang JS, Mochida S, Chen XL, Shin Y, Noda M, Hossain KZ, Hoshi N, Hashii M, Shigemoto R, Nakanishi S, Fukuda Y, Yokoyama S. PMID: 12753074.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci. 2003 Jun; 6(6):564-71.
Hoshi N, Zhang JS, Omaki M, Takeuchi T, Yokoyama S, Wanaverbecq N, Langeberg LK, Yoneda Y, Scott JD, Brown DA, Higashida H. PMID: 12754513; PMCID: PMC3941299.
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PubMed Mentions:
124 Fields:
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AnimalsCells
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Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4445-50.
Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD. PMID: 12672969; PMCID: PMC153575.
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PubMed Mentions:
72 Fields:
Translation:
HumansCells
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Clinical and electrophysiological characterization of a novel mutation (F193L) in the KCNQ1 gene associated with long QT syndrome. Clin Sci (Lond). 2003 Apr; 104(4):377-82.
Yamaguchi M, Shimizu M, Ino H, Terai H, Hayashi K, Mabuchi H, Hoshi N, Higashida H. PMID: 12653681.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Ultrastructure of endothelial cells under flow alteration. Microsc Res Tech. 2003 Jan 01; 60(1):2-12.
Masuda H, Kawamura K, Nanjo H, Sho E, Komatsu M, Sugiyama T, Sugita A, Asari Y, Kobayashi M, Ebina T, Hoshi N, Singh TM, Xu C, Zarins CK. PMID: 12500255.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Physiological angiogenesis in electrically stimulated skeletal muscle in rabbits: characterization of capillary sprouting by ultrastructural 3-D reconstruction study. Pathol Int. 2002 Nov; 52(11):702-12.
Ebina T, Hoshi N, Kobayashi M, Kawamura K, Nanjo H, Sugita A, Sugiyama T, Masuda H, Xu C. PMID: 12685547.
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PubMed Mentions:
4 Fields:
Translation:
Animals