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Lulu y Chen

Title(s)Assistant Professor, Anatomy and Neurobiology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-3503
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    Collapse Biography 
    Collapse Education and Training
    California State University, Long Beach, CaliforniaBS12/2004Biological Science-Physiology
    University of California, Irvine, CaliforniaPhD12/2009Anatomy and Neurobiology
    Stanford University, Palo Alto, CaliforniaResearch Associate9/2018Neuroscience

    Collapse Overview 
    Collapse Overview
    Synapses are the connections between neurons in a vast communicating network. The synapses have been proposed to be sites of information processing and memory storage, and their functional deficits the key to cognitive disorders and diseases. Our research focuses on the molecular mechanisms underlying synapse development and functions in learning and memory. Not only is this area interesting and poorly understood, but it is critical to our understanding of cognitive disorders and mental disabilities. Our studies may ultimately lead to the discovery of treatments that improve the life quality of patients suffering from congenital syndromes (e.g. autism spectrum disorder (ASD), fragile X syndrome (FXS), schizophrenia (SCZ)) or cognitive problems associated with traumatic experience or aging.
    We aim to identify the key molecules and their signaling cascades involved in in synapse formation and functions in learning and memory and their deficits in various disease conditions. We are particularly interested in the activity-dependent signaling pathways underlying synaptic structural changes. We study different synapse types in the brain, how these synapses form, function, and been regulated. We take advantage of genetic and molecular approaches which enable accurately target the specific types of neurons/synapses located at specific brain regions (spatial control) at specific development window (temporal control) to ask that how the synapses are developmentally regulated and how this regulatory mechanism fail in the disordered brains.

    Collapse Research 
    Collapse Research Activities and Funding
    Role of Neurexin in Synapse Formation and Maintenance
    NIH/NIMH F32MH100745May 1, 2013 - Apr 30, 2016
    Role: Principal Investigator
    BDNF/TrkB Regulates Actin Signaling with LTP
    NIH/NIMH F31MH083396Apr 16, 2008 - Dec 3, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins. Neuron. 2017 May 03; 94(3):611-625.e4. Chen LY, Jiang M, Zhang B, Gokce O, Südhof TC. PMID: 28472659.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    2. Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism. Mol Psychiatry. 2017 03; 22(3):375-383. Jiang M, Polepalli J, Chen LY, Zhang B, Südhof TC, Malenka RC. PMID: 27217145.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    3. Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses. Neuron. 2015 Aug 19; 87(4):781-96. Zhang B, Chen LY, Liu X, Maxeiner S, Lee SJ, Gokce O, Südhof TC. PMID: 26291161.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    4. Synaptic abnormalities in the infralimbic cortex of a model of congenital depression. J Neurosci. 2013 Aug 14; 33(33):13441-8. Seese RR, Chen LY, Cox CD, Schulz D, Babayan AH, Bunney WE, Henn FA, Gall CM, Lynch G. PMID: 23946402.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    5. Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. J Neurosci. 2012 Sep 12; 32(37):12854-61. Babayan AH, Kramár EA, Barrett RM, Jafari M, Häettig J, Chen LY, Rex CS, Lauterborn JC, Wood MA, Gall CM, Lynch G. PMID: 22973009.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    6. BDNF signaling during learning is regionally differentiated within hippocampus. J Neurosci. 2010 Nov 10; 30(45):15097-101. Chen LY, Rex CS, Pham DT, Lynch G, Gall CM. PMID: 21068315.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    7. Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation. Neuron. 2010 Aug 26; 67(4):603-17. Rex CS, Gavin CF, Rubio MD, Kramar EA, Chen LY, Jia Y, Huganir RL, Muzyczka N, Gall CM, Miller CA, Lynch G, Rumbaugh G. PMID: 20797537.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    8. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. J Neurosci. 2010 Aug 18; 30(33):10977-84. Chen LY, Rex CS, Babayan AH, Kramár EA, Lynch G, Gall CM, Lauterborn JC. PMID: 20720104.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    9. BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. Neurobiol Aging. 2012 Apr; 33(4):708-19. Kramár EA, Chen LY, Lauterborn JC, Simmons DA, Gall CM, Lynch G. PMID: 20674095.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    10. Learning induces neurotrophin signaling at hippocampal synapses. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):7030-5. Chen LY, Rex CS, Sanaiha Y, Lynch G, Gall CM. PMID: 20356829.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    11. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci. 2009 Oct 14; 29(41):12982-93. Kramár EA, Chen LY, Brandon NJ, Rex CS, Liu F, Gall CM, Lynch G. PMID: 19828812.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    12. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation. J Cell Biol. 2009 Jul 13; 186(1):85-97. Rex CS, Chen LY, Sharma A, Liu J, Babayan AH, Gall CM, Lynch G. PMID: 19596849.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    13. Estrogen's Place in the Family of Synaptic Modulators. Mol Cell Pharmacol. 2009 Jan 01; 1(5):258-262. Kramár EA, Chen LY, Rex CS, Gall CM, Lynch G. PMID: 20419049.
      View in: PubMed   Mentions:
    14. The substrates of memory: defects, treatments, and enhancement. Eur J Pharmacol. 2008 May 06; 585(1):2-13. Lynch G, Rex CS, Chen LY, Gall CM. PMID: 18374328.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    15. Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome. J Neurosci. 2007 Oct 03; 27(40):10685-94. Lauterborn JC, Rex CS, Kramár E, Chen LY, Pandyarajan V, Lynch G, Gall CM. PMID: 17913902.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    16. Changes in synaptic morphology accompany actin signaling during LTP. J Neurosci. 2007 May 16; 27(20):5363-72. Chen LY, Rex CS, Casale MS, Gall CM, Lynch G. PMID: 17507558.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    17. Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus. J Neurosci. 2007 Mar 14; 27(11):3017-29. Rex CS, Lin CY, Kramár EA, Chen LY, Gall CM, Lynch G. PMID: 17360925.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
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