Wenqi Wang

Title(s)Professor, Developmental & Cell Biology
SchoolDunlop School of Biological Sciences
Address3302A Natural Sciences 1
Zot 2300
Irvine CA 92697
Phone(949) 824-4977
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    Collapse Research 
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    Mechanisms of the Hippo pathway in growth control
    NIH R35GM163464Aug 1, 2026 - Jul 31, 2031
    Role: Principal Investigator
    Hippo Pathway in Biology and Diseases
    NIH R13CA294857Sep 1, 2024 - Aug 31, 2025
    Role: Principal Investigator
    Interplay of heavy metal homeostasis and cell growth-related signaling networks
    NIH R01GM143233Aug 4, 2022 - Jul 31, 2026
    Role: Principal Investigator
    Dissecting the role of Hippo signaling in platinum-based chemotherapy
    NIH R21ES031642Dec 4, 2020 - Nov 30, 2023
    Role: Principal Investigator
    Regulation and function of the Hippo pathway in growth control
    NIH R01GM126048Feb 1, 2018 - Jan 31, 2027
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Proteomic Analysis of Hippo Pathway Protein-Protein Interactions. Cold Spring Harb Perspect Biol. 2026 Jul 29. An J, Wang W. PMID: 42527313.
      View in: PubMed   Mentions:    Fields:    
    2. BET inhibition curbs macrophage inflammation, lipid accumulation, and atherogenesis by disrupting the YAP/TAZ-BRD4 axis. J Leukoc Biol. 2026 Jul 03; 118(7). Veerasubramanian PK, Meli VS, Atcha H, Wang W, Downing TL, Liu WF. PMID: 42054500; PMCID: PMC13412306.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. STK38/L promote tissue growth and cancer by inhibiting the Hippo pathway. Genes Dev. 2026 07 01; 40(13-14):1080-1098. An J, Huang Z, Kizhedathu A, Lan T, Lin T, Joo H, Thilakaratne EM, Liu Y, Xu YY, Yang B, Lara-Gonzalez P, Warrior R, Luo R, Wang W. PMID: 42128666.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Bioinformatic analysis of metastasis-associated metabolic landscape reveals an oncogenic role for the transsulfuration pathway. Bioinform Adv. 2026; 6(1):vbag084. Yan JK, Yang Y, Wang W. PMID: 41923956; PMCID: PMC13037812.
      View in: PubMed   Mentions:
    5. Correction: Hippo signaling dysfunction induces cancer cell addiction to YAP. Oncogene. 2026 Mar; 45(11):1068-1069. Han H, Yang B, Nakaoka HJ, Yang J, Zhao Y, Le Nguyen K, Bishara AT, Mandalia TK, Wang W. PMID: 41781669.
      View in: PubMed   Mentions:    Fields:    
    6. Glutamine synthetase modulates YAP activation by stabilizing LATS under glutamine homeostasis. Cell Rep. 2025 12 23; 44(12):116620. Li S, Ling T, Wang Y, Shi J, Wang Q, Lv J, Li J, Liu Y, Zhang Y, Liu C, Xia T, Chen D, Wang W, Liu HX, Piao HL. PMID: 41296569.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. MAP4K signaling pathways in cancer: roles, mechanisms and therapeutic opportunities. Exp Mol Med. 2025 Oct; 57(10):2148-2156. Bunardi CS, Yeom M, Kosasih P, Han H, Wang W, Seo G. PMID: 41034525; PMCID: PMC12586695.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Foxh1 is a locus-specific PRC2 recruiter governing germ layer silencing. bioRxiv. 2025 Sep 22. Cho J, Hendrickson CL, Mar N, Blitz IL, Fish M, Wang W, Cho KWY. PMID: 41040321; PMCID: PMC12485744.
      View in: PubMed   Mentions:
    9. The Hippo pathway promotes platinum-based chemotherapy by inhibiting MTF1-dependent heavy metal response. BMC Cancer. 2025 Feb 08; 25(1):223. Chen H, Xu Y, Chen D, Xiao D, Yang B, Wang W, Han H. PMID: 39920630; PMCID: PMC11806854.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Author Correction: Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation. Nat Commun. 2024 Dec 10; 15(1):10663. Shi C, Wang Y, Wu M, Chen Y, Liu F, Shen Z, Wang Y, Xie S, Shen Y, Sang L, Zhang Z, Gao Z, Yang L, Qu L, Yang Z, He X, Guo Y, Pan C, Che J, Ju H, Liu J, Cai Z, Yan Q, Yu L, Wang L, Dong X, Xu P, Shao J, Liu Y, Li X, Wang W, Zhou R, Zhou T, Lin A. PMID: 39658552; PMCID: PMC11631968.
      View in: PubMed   Mentions:    Fields:    
    11. Functional annotation of the Hippo pathway somatic mutations in human cancers. Nat Commun. 2024 11 21; 15(1):10106. Han H, Huang Z, Xu C, Seo G, An J, Yang B, Liu Y, Lan T, Yan J, Ren S, Xu Y, Xiao D, Yan JK, Ahn C, Fishman DA, Meng Z, Guan KL, Qi R, Luo R, Wang W. PMID: 39572544; PMCID: PMC11582751.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Characterization of ATG8-family protein phosphorylation by Phos-tag gel for autophagy study. STAR Protoc. 2024 03 15; 5(1):102872. Seo G, Wang W. PMID: 38319785; PMCID: PMC10850991.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    13. MAP4K2 connects the Hippo pathway to autophagy in response to energy stress. Autophagy. 2024 03; 20(3):704-706. Seo G, Mckinley J, Wang W. PMID: 37937799; PMCID: PMC10936684.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress. Mol Cell. 2023 09 07; 83(17):3155-3170.e8. Seo G, Yu C, Han H, Xing L, Kattan RE, An J, Kizhedathu A, Yang B, Luo A, Buckle AL, Tifrea D, Edwards R, Huang L, Ju HQ, Wang W. PMID: 37595580; PMCID: PMC10568779.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    15. Transcriptional network governing extraembryonic endoderm cell fate choice. Dev Biol. 2023 10; 502:20-37. Pham PD, Lu H, Han H, Zhou JJ, Madan A, Wang W, Murre C, Cho KWY. PMID: 37423592; PMCID: PMC10550205.
      View in: PubMed   Mentions: 7     Fields:    
    16. Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells. Sci Signal. 2023 05 02; 16(783):eadc9656. Meli VS, Veerasubramanian PK, Downing TL, Wang W, Liu WF. PMID: 37130167; PMCID: PMC10625748.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    17. LncRNA modulates Hippo-YAP signaling to reprogram iron metabolism. Nat Commun. 2023 04 20; 14(1):2253. He XY, Fan X, Qu L, Wang X, Jiang L, Sang LJ, Shi CY, Lin S, Yang JC, Yang ZZ, Lei K, Li JH, Ju HQ, Yan Q, Liu J, Wang F, Shao J, Xiong Y, Wang W, Lin A. PMID: 37080959; PMCID: PMC10119135.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    18. A tale of two Hippo pathway modules. EMBO J. 2023 06 01; 42(11):e113970. Han H, Wang W. PMID: 37073568; PMCID: PMC10233370.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis. Elife. 2023 03 27; 12. Zhou JJ, Cho JS, Han H, Blitz IL, Wang W, Cho KWY. PMID: 36971347; PMCID: PMC10079291.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    20. Analysis of affinity purification-related proteomic data for studying protein-protein interaction networks in cells. Brief Bioinform. 2023 03 19; 24(2). Kattan RE, Ayesh D, Wang W. PMID: 36682002; PMCID: PMC10025443.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    21. Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation. Nat Commun. 2022 11 14; 13(1):6951. Shi C, Wang Y, Wu M, Chen Y, Liu F, Shen Z, Wang Y, Xie S, Shen Y, Sang L, Zhang Z, Gao Z, Yang L, Qu L, Yang Z, He X, Guo Y, Pan C, Che J, Ju H, Liu J, Cai Z, Yan Q, Yu L, Wang L, Dong X, Xu P, Shao J, Liu Y, Li X, Wang W, Zhou R, Zhou T, Lin A. PMID: 36376293; PMCID: PMC9663433.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    22. Putting a leash on Hippo. Nat Chem Biol. 2022 Oct; 18(10):1039-1040. Seo G, Wang W. PMID: 35788179.
      View in: PubMed   Mentions: 1     Fields:    
    23. Engagement of Foxh1 in chromatin regulation revealed by protein interactome analyses. Dev Growth Differ. 2022 Aug; 64(6):297-305. Zhou JJ, Pham PD, Han H, Wang W, Cho KWY. PMID: 35848281; PMCID: PMC9474667.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. Protocol for establishing a protein-protein interaction network using tandem affinity purification followed by mass spectrometry in mammalian cells. STAR Protoc. 2022 09 16; 3(3):101569. Bian W, Jiang H, Feng S, Chen J, Wang W, Li X. PMID: 35874475; PMCID: PMC9304681.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    25. Functional interplay between the Hippo pathway and heavy metals. Mol Cell Oncol. 2022; 9(1):2061297. Han H, Mahieu A, de Paula LD, Wang W. PMID: 35434269; PMCID: PMC9009939.
      View in: PubMed   Mentions: 1  
    26. The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1. Nat Cell Biol. 2022 01; 24(1):74-87. Han H, Nakaoka HJ, Hofmann L, Zhou JJ, Yu C, Zeng L, Nan J, Seo G, Vargas RE, Yang B, Qi R, Bardwell L, Fishman DA, Cho KWY, Huang L, Luo R, Warrior R, Wang W. PMID: 35027733; PMCID: PMC9022944.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    27. Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network. Mol Cell Proteomics. 2022 02; 21(2):100195. Kattan RE, Han H, Seo G, Yang B, Lin Y, Dotson M, Pham S, Menely Y, Wang W. PMID: 35007762; PMCID: PMC8864472.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    28. Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation. Dev Cell. 2021 10 25; 56(20):2902-2919.e8. Bian W, Tang M, Jiang H, Xu W, Hao W, Sui Y, Hou Y, Nie L, Zhang H, Wang C, Li N, Wang J, Qin J, Wu L, Ma X, Chen J, Wang W, Li X. PMID: 34626540.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    29. YAP-mediated mechanotransduction tunes the macrophage inflammatory response. Sci Adv. 2020 12; 6(49). Meli VS, Atcha H, Veerasubramanian PK, Nagalla RR, Luu TU, Chen EY, Guerrero-Juarez CF, Yamaga K, Pandori W, Hsieh JY, Downing TL, Fruman DA, Lodoen MB, Plikus MV, Wang W, Liu WF. PMID: 33277245; PMCID: PMC7717914.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansCells
    30. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. Cell Rep. 2020 07 07; 32(1):107860. Seo G, Han H, Vargas RE, Yang B, Li X, Wang W. PMID: 32640226; PMCID: PMC7382313.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    31. Significance of long non-coding RNA AGPG for the metabolism of esophageal cancer. Cancer Commun (Lond). 2020 07; 40(7):313-315. Vargas RE, Wang W. PMID: 32449319; PMCID: PMC7365456.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    32. Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution. Sci Rep. 2020 02 21; 10(1):3173. Chen Y, Han H, Seo G, Vargas RE, Yang B, Chuc K, Zhao H, Wang W. PMID: 32081887; PMCID: PMC7035326.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    33. Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor. EMBO J. 2020 01 02; 39(1):e102406. Vargas RE, Duong VT, Han H, Ta AP, Chen Y, Zhao S, Yang B, Seo G, Chuc K, Oh S, El Ali A, Razorenova OV, Chen J, Luo R, Li X, Wang W. PMID: 31782549; PMCID: PMC6939200.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    34. An Acute Stress Model in New Zealand White Rabbits Exhibits Altered Immune Response to Infection with West Nile Virus. Pathogens. 2019 Oct 18; 8(4). Suen WW, Imoda M, Thomas AW, Nasir NNBM, Tearnsing N, Wang W, Bielefeldt-Ohmann H. PMID: 31635289; PMCID: PMC6963736.
      View in: PubMed   Mentions: 4     Fields:    
    35. Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528. Nat Commun. 2019 01 16; 10(1):228. Chapman DE, Reddy BJN, Huy B, Bovyn MJ, Cruz SJS, Al-Shammari ZM, Han H, Wang W, Smith DS, Gross SP. PMID: 30651536; PMCID: PMC6335402.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    36. Phosphatidic acid: a lipid regulator of the Hippo pathway. Mol Cell Oncol. 2019; 6(1):1558683. Han H, Vargas R, Seo G, Wang W. PMID: 30788423; PMCID: PMC6370377.
      View in: PubMed   Mentions: 3  
    37. Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell. 2018 10 18; 72(2):328-340.e8. Han H, Qi R, Zhou JJ, Ta AP, Yang B, Nakaoka HJ, Seo G, Guan KL, Luo R, Wang W. PMID: 30293781; PMCID: PMC6195446.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    38. Hippo signaling dysfunction induces cancer cell addiction to YAP. Oncogene. 2018 12; 37(50):6414-6424. Han H, Yang B, Nakaoka HJ, Yang J, Zhao Y, Le Nguyen K, Bishara AT, Mandalia TK, Wang W. PMID: 30068939; PMCID: PMC6294669.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    39. LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. EMBO J. 2017 11 15; 36(22):3325-3335. Zheng X, Han H, Liu GP, Ma YX, Pan RL, Sang LJ, Li RH, Yang LJ, Marks JR, Wang W, Lin A. PMID: 28963395; PMCID: PMC5686550.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    40. Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy. Cell Rep. 2017 07 18; 20(3):737-749. Li X, Han H, Zhou MT, Yang B, Ta AP, Li N, Chen J, Wang W. PMID: 28723574.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    41. Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling. Mol Cell Proteomics. 2017 04; 16(4):594-607. Li X, Gao M, Choi JM, Kim BJ, Zhou MT, Chen Z, Jain AN, Jung SY, Yuan J, Wang W, Wang Y, Chen J. PMID: 28174230; PMCID: PMC5383781.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    42. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 09; 15(9):3030-44. Li X, Tran KM, Aziz KE, Sorokin AV, Chen J, Wang W. PMID: 27432908; PMCID: PMC5013315.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    43. Role of Feline Immunodeficiency Virus in Lymphomagenesis--Going Alone or Colluding? ILAR J. 2016; 57(1):24-33. Kaye S, Wang W, Miller C, McLuckie A, Beatty JA, Grant CK, VandeWoude S, Bielefeldt-Ohmann H. PMID: 27034392.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    44. The Australian Public is Still Vulnerable to Emerging Virulent Strains of West Nile Virus. Front Public Health. 2014; 2:146. Prow NA, Hewlett EK, Faddy HM, Coiacetto F, Wang W, Cox T, Hall RA, Bielefeldt-Ohmann H. PMID: 25279370; PMCID: PMC4166114.
      View in: PubMed   Mentions: 12     Fields:    
    45. Natural exposure of horses to mosquito-borne flaviviruses in south-east Queensland, Australia. Int J Environ Res Public Health. 2013 Sep 17; 10(9):4432-43. Prow NA, Tan CS, Wang W, Hobson-Peters J, Kidd L, Barton A, Wright J, Hall RA, Bielefeldt-Ohmann H. PMID: 24048209; PMCID: PMC3799510.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
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