Phang-Lang Chen

Title(s)	Professor Emeritus, Biological Chemistry
School	School of Medicine
Address	1001 Health Sciences Road Irvine CA 92697-3950
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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The Link between Autosomal Dominant Polycystic Kidney Disease and Chromosomal Instability: Exploring the Relationship. Int J Mol Sci. 2024 Mar 02; 25(5). Chen PL, Chen CF, Lin HY, Riley DJ, Chen Y. PMID: 38474184; PMCID: PMC10932443.

View in: PubMed Mentions: Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Humans
Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury. Apoptosis. 2024 Jun; 29(5-6):620-634. Lin HY, Liang CJ, Yang MY, Chen PL, Wang TM, Chen YH, Shih YH, Liu W, Chiu CC, Chiang CK, Lin CS, Lin HC. PMID: 38281282; PMCID: PMC11055741.

View in: PubMed Mentions: Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Mitochondrial Signaling, the Mechanisms of AKI-to-CKD Transition and Potential Treatment Targets. Int J Mol Sci. 2024 Jan 26; 25(3). Chang LY, Chao YL, Chiu CC, Chen PL, Lin HY. PMID: 38338797; PMCID: PMC10855342.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Humans Animals Cells
Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism. Cardiovasc Diabetol. 2023 10 27; 22(1):294. Chen YH, Ta AP, Chen Y, Lee HC, Fan W, Chen PL, Jordan MC, Roos KP, MacGregor GR, Yang Q, Edwards RA, Li J, Wang PH. PMID: 37891673; PMCID: PMC10612246.

View in: PubMed Mentions: Fields:
Car Cardiology End Endocrinology Vas Vascular Diseases
Translation:Animals Cells
BRCA1 the Versatile Defender: Molecular to Environmental Perspectives. Int J Mol Sci. 2023 Sep 19; 24(18). Zhong AX, Chen Y, Chen PL. PMID: 37762577; PMCID: PMC10532398.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Humans Cells
SUV3 Helicase and Mitochondrial Homeostasis. Int J Mol Sci. 2023 May 25; 24(11). Chen PL. PMID: 37298184; PMCID: PMC10253155.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Animals Cells
High risk of renal outcome of metabolic syndrome independent of diabetes in patients with CKD stage 1-4: The ICKD database. Diabetes Metab Res Rev. 2023 05; 39(4):e3618. Lin HY, Chang LY, Niu SW, Kuo IC, Yen CH, Shen FC, Chen PL, Chang JM, Hung CC. PMID: 36731513.

View in: PubMed Mentions: 1 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Aberrant DNA damage response and DNA repair pathway in high glucose conditions. J Can Res Updates. 2018; 7(3):64-74. Zhong A, Chang M, Yu T, Gau R, Riley DJ, Chen Y, Chen PL. PMID: 30498558; PMCID: PMC6258084.

View in: PubMed Mentions: 18
Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment. Oncotarget. 2014 Jun 30; 5(12):4283-94. Chen Y, Chen CF, Polci R, Wei R, Riley DJ, Chen PL. PMID: 24970796; PMCID: PMC4147323.

View in: PubMed Mentions: 14 Fields:
Neo Neoplasms
Translation:Humans Cells
Helicase SUV3, polynucleotide phosphorylase, and mitochondrial polyadenylation polymerase form a transient complex to modulate mitochondrial mRNA polyadenylated tail lengths in response to energetic changes. J Biol Chem. 2014 Jun 13; 289(24):16727-35. Wang DD, Guo XE, Modrek AS, Chen CF, Chen PL, Lee WH. PMID: 24770417; PMCID: PMC4059117.

View in: PubMed Mentions: 23 Fields:
Bio Biochemistry
Translation:Humans Cells
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med. 2013 Mar; 5(3):353-65. Zhu J, Zhou L, Wu G, Konig H, Lin X, Li G, Qiu XL, Chen CF, Hu CM, Goldblatt E, Bhatia R, Chamberlin AR, Chen PL, Lee WH. PMID: 23341130; PMCID: PMC3598077.

View in: PubMed Mentions: 47 Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med. 2013 Jan 14; 210(1):115-23. Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, Robbiani DF. PMID: 23254285; PMCID: PMC3549709.

View in: PubMed Mentions: 31 Fields:
All Allergy and Immunology Med Medicine (General)
Translation:Animals Cells
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. Mol Cell. 2012 Dec 14; 48(5):747-59. Wei PC, Hsieh YH, Su MI, Jiang X, Hsu PH, Lo WT, Weng JY, Jeng YM, Wang JM, Chen PL, Chang YC, Lee KF, Tsai MD, Shew JY, Lee WH. PMID: 23123197; PMCID: PMC3582359.

View in: PubMed Mentions: 75 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Oncogene. 2013 Feb 28; 32(9):1193-201. Chen PL, Chen CF, Chen Y, Guo XE, Huang CK, Shew JY, Reddick RL, Wallace DC, Lee WH. PMID: 22562243; PMCID: PMC3416964.

View in: PubMed Mentions: 25 Fields:
Mol Molecular Biology Neo Neoplasms
Translation:Humans Animals Cells
Uncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation. J Biol Chem. 2011 Nov 04; 286(44):38783-38794. Guo XE, Chen CF, Wang DD, Modrek AS, Phan VH, Lee WH, Chen PL. PMID: 21911497; PMCID: PMC3207411.

View in: PubMed Mentions: 13 Fields:
Bio Biochemistry
Translation:Animals Cells
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle. 2011 Feb 15; 10(4):655-63. Chen Y, Chen CF, Riley DJ, Chen PL. PMID: 21301226; PMCID: PMC3173995.

View in: PubMed Mentions: 43 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability. Mol Cancer. 2011 Jan 10; 10(1):5. Chen Y, Chen CF, Chiang HC, Pena M, Polci R, Wei RL, Edwards RA, Hansel DE, Chen PL, Riley DJ. PMID: 21214959; PMCID: PMC3025975.

View in: PubMed Mentions: 29 Fields:
Neo Neoplasms
Translation:Animals
Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality. J Biol Chem. 2009 Jul 31; 284(31):20812-21. Wang DD, Shu Z, Lieser SA, Chen PL, Lee WH. PMID: 19509288; PMCID: PMC2742846.

View in: PubMed Mentions: 58 Fields:
Bio Biochemistry
Translation:Humans Cells
Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint. Cell Cycle. 2009 May 01; 8(9):1409-20. Gu B, Chen PL. PMID: 19342888.

View in: PubMed Mentions: 14 Fields:
Cel Cell Biology
Translation:Humans Cells
Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J Med Chem. 2009 Mar 26; 52(6):1757-67. Qiu XL, Li G, Wu G, Zhu J, Zhou L, Chen PL, Chamberlin AR, Lee WH. PMID: 19243176; PMCID: PMC2670097.

View in: PubMed Mentions: 20 Fields:
Che Chemistry
Translation:Humans Cells
Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control. Cell Cycle. 2008 Oct; 7(20):3194-201. Chen Y, Chen PL, Chen CF, Jiang X, Riley DJ. PMID: 18843199; PMCID: PMC2597191.

View in: PubMed Mentions: 47 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 2008 Oct 15; 68(20):8393-9. Wu G, Qiu XL, Zhou L, Zhu J, Chamberlin R, Lau J, Chen PL, Lee WH. PMID: 18922912; PMCID: PMC2709694.

View in: PubMed Mentions: 54 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. J Proteome Res. 2008 Nov; 7(11):4914-25. Fang L, Wang X, Yamoah K, Chen PL, Pan ZQ, Huang L. PMID: 18850735; PMCID: PMC2676908.

View in: PubMed Mentions: 30 Fields:
Bio Biochemistry
Translation:Humans Cells
Structural requirements of chromokinesin Kif4A for its proper function in mitosis. Biochem Biophys Res Commun. 2008 Aug 01; 372(3):454-8. Wu G, Chen PL. PMID: 18502200.

View in: PubMed Mentions: 18 Fields:
Bio Biochemistry Bio Biophysics
Translation:Humans Animals Cells
A novel role of the chromokinesin Kif4A in DNA damage response. Cell Cycle. 2008 Jul 01; 7(13):2013-20. Wu G, Zhou L, Khidr L, Guo XE, Kim W, Lee YM, Krasieva T, Chen PL. PMID: 18604178; PMCID: PMC3121316.

View in: PubMed Mentions: 39 Fields:
Cel Cell Biology
Translation:Humans Cells
Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37. Front Biosci. 2008 Jan 01; 13:240-8. Tawara H, Fujiuchi N, Sironi J, Martin S, Aglipay J, Ouchi M, Taga M, Chen PL, Ouchi T. PMID: 17981542.

View in: PubMed Mentions: 5 Fields:
Bio Biology
Translation:Humans Cells
Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry. 2007 Mar 20; 46(11):3553-65. Wang X, Chen CF, Baker PR, Chen PL, Kaiser P, Huang L. PMID: 17323924.

View in: PubMed Mentions: 140 Fields:
Bio Biochemistry
Translation:Humans Cells
Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell. 2006 Jul; 10(1):13-24. Furuta S, Wang JM, Wei S, Jeng YM, Jiang X, Gu B, Chen PL, Lee EY, Lee WH. PMID: 16843262.

View in: PubMed Mentions: 53 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9176-81. Furuta S, Jiang X, Gu B, Cheng E, Chen PL, Lee WH. PMID: 15967981; PMCID: PMC1166629.

View in: PubMed Mentions: 60 Fields:
Sci Science
Translation:Humans Cells
Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol Cell Biol. 2005 May; 25(9):3535-42. Chen PL, Liu F, Cai S, Lin X, Li A, Chen Y, Gu B, Lee EY, Lee WH. PMID: 15831459; PMCID: PMC1084307.

View in: PubMed Mentions: 90 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. J Cell Sci. 2005 Apr 15; 118(Pt 8):1629-39. Townsend PA, Cragg MS, Davidson SM, McCormick J, Barry S, Lawrence KM, Knight RA, Hubank M, Chen PL, Latchman DS, Stephanou A. PMID: 15784679.

View in: PubMed Mentions: 28 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
NFBD1/Mdc1 mediates ATR-dependent DNA damage response. Cancer Res. 2005 Feb 15; 65(4):1158-63. Peng A, Chen PL. PMID: 15734998.

View in: PubMed Mentions: 10 Fields:
Neo Neoplasms
Translation:Humans Cells
NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. Cancer Res. 2004 Dec 15; 64(24):8800-3. Polci R, Peng A, Chen PL, Riley DJ, Chen Y. PMID: 15604234.

View in: PubMed Mentions: 42 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. J Biol Chem. 2004 Oct 15; 279(42):43522-9. Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH. PMID: 15294905.

View in: PubMed Mentions: 43 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change. Biochemistry. 2004 Apr 27; 43(16):4781-90. Shu Z, Vijayakumar S, Chen CF, Chen PL, Lee WH. PMID: 15096047.

View in: PubMed Mentions: 24 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1. Cancer Res. 2003 May 15; 63(10):2589-95. Wu G, Jiang X, Lee WH, Chen PL. PMID: 12750284.

View in: PubMed Mentions: 59 Fields:
Neo Neoplasms
Translation:Humans Cells
NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. J Biol Chem. 2003 Mar 14; 278(11):8873-6. Peng A, Chen PL. PMID: 12551934.

View in: PubMed Mentions: 30 Fields:
Bio Biochemistry
Translation:Humans Cells
NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response. J Biol Chem. 2003 Feb 21; 278(8):6323-9. Shang YL, Bodero AJ, Chen PL. PMID: 12475977.

View in: PubMed Mentions: 16 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation. J Biol Chem. 2002 Dec 20; 277(51):49408-16. Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH. PMID: 12386167.

View in: PubMed Mentions: 52 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Cell lineage-specific effects associated with multiple deficiencies of tumor susceptibility genes in Msh2(-/-)Rb(+/-) mice. Cancer Res. 2002 Sep 15; 62(18):5134-8. Nikitin AY, Liu CY, Flesken-Nikitin A, Chen CF, Chen PL, Lee WH. PMID: 12234974.

View in: PubMed Mentions: 7 Fields:
Neo Neoplasms
Translation:Animals Cells
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science. 2002 Sep 13; 297(5588):1837-48. Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP. PMID: 12228710.

View in: PubMed Mentions: 296 Fields:
Sci Science
Translation:Humans Animals Cells
Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res. 2002 Jul 15; 62(14):3966-70. Zhong Q, Boyer TG, Chen PL, Lee WH. PMID: 12124328.

View in: PubMed Mentions: 44 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J Biol Chem. 2002 Aug 09; 277(32):28641-7. Zhong Q, Chen CF, Chen PL, Lee WH. PMID: 12039951.

View in: PubMed Mentions: 45 Fields:
Bio Biochemistry
Translation:Animals Cells
Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability. Cancer Res. 2002 May 01; 62(9):2498-502. Zheng L, Flesken-Nikitin A, Chen PL, Lee WH. PMID: 11980640.

View in: PubMed Mentions: 34 Fields:
Neo Neoplasms
Translation:Animals Cells