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Chen, Phang-Lang

TitleAssociate Professor
InstitutionUniversity of California, Irvine
DepartmentBiological Chemistry
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-4008
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen Y, Chen CF, Polci R, Wei R, Riley DJ, Chen PL. Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment. Oncotarget. 2014 Jun 30; 5(12):4283-94. PMID: 24970796; PMCID: PMC4147323.
    2. Wang DD, Guo XE, Modrek AS, Chen CF, Chen PL, Lee WH. Helicase SUV3, polynucleotide phosphorylase, and mitochondrial polyadenylation polymerase form a transient complex to modulate mitochondrial mRNA polyadenylated tail lengths in response to energetic changes. J Biol Chem. 2014 Jun 13; 289(24):16727-35. PMID: 24770417; PMCID: PMC4059117.
    3. Zhu J, Zhou L, Wu G, Konig H, Lin X, Li G, Qiu XL, Chen CF, Hu CM, Goldblatt E, Bhatia R, Chamberlin AR, Chen PL, Lee WH. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med. 2013 Mar; 5(3):353-65. PMID: 23341130; PMCID: PMC3598077.
    4. Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, Robbiani DF. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med. 2013 Jan 14; 210(1):115-23. PMID: 23254285; PMCID: PMC3549709.
    5. Wei PC, Hsieh YH, Su MI, Jiang X, Hsu PH, Lo WT, Weng JY, Jeng YM, Wang JM, Chen PL, Chang YC, Lee KF, Tsai MD, Shew JY, Lee WH. Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. Mol Cell. 2012 Dec 14; 48(5):747-59. PMID: 23123197; PMCID: PMC3582359.
    6. Chen PL, Chen CF, Chen Y, Guo XE, Huang CK, Shew JY, Reddick RL, Wallace DC, Lee WH. Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Oncogene. 2013 Feb 28; 32(9):1193-201. PMID: 22562243; PMCID: PMC3416964.
    7. Guo XE, Chen CF, Wang DD, Modrek AS, Phan VH, Lee WH, Chen PL. Uncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation. J Biol Chem. 2011 Nov 04; 286(44):38783-94. PMID: 21911497; PMCID: PMC3207411.
    8. Chen Y, Chen CF, Riley DJ, Chen PL. Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle. 2011 Feb 15; 10(4):655-63. PMID: 21301226; PMCID: PMC3173995.
    9. Chen Y, Chen CF, Chiang HC, Pena M, Polci R, Wei RL, Edwards RA, Hansel DE, Chen PL, Riley DJ. Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability. Mol Cancer. 2011 Jan 10; 10(1):5. PMID: 21214959; PMCID: PMC3025975.
    10. Wang DD, Shu Z, Lieser SA, Chen PL, Lee WH. Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality. J Biol Chem. 2009 Jul 31; 284(31):20812-21. PMID: 19509288; PMCID: PMC2742846.
    11. Gu B, Chen PL. Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint. Cell Cycle. 2009 May 01; 8(9):1409-20. PMID: 19342888.
      View in: PubMed
    12. Qiu XL, Li G, Wu G, Zhu J, Zhou L, Chen PL, Chamberlin AR, Lee WH. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J Med Chem. 2009 Mar 26; 52(6):1757-67. PMID: 19243176; PMCID: PMC2670097.
    13. Chen Y, Chen PL, Chen CF, Jiang X, Riley DJ. Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control. Cell Cycle. 2008 Oct; 7(20):3194-201. PMID: 18843199; PMCID: PMC2597191.
    14. Wu G, Qiu XL, Zhou L, Zhu J, Chamberlin R, Lau J, Chen PL, Lee WH. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 2008 Oct 15; 68(20):8393-9. PMID: 18922912; PMCID: PMC2709694.
    15. Fang L, Wang X, Yamoah K, Chen PL, Pan ZQ, Huang L. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. J Proteome Res. 2008 Nov; 7(11):4914-25. PMID: 18850735; PMCID: PMC2676908.
    16. Wu G, Chen PL. Structural requirements of chromokinesin Kif4A for its proper function in mitosis. Biochem Biophys Res Commun. 2008 Aug 01; 372(3):454-8. PMID: 18502200.
      View in: PubMed
    17. Wu G, Zhou L, Khidr L, Guo XE, Kim W, Lee YM, Krasieva T, Chen PL. A novel role of the chromokinesin Kif4A in DNA damage response. Cell Cycle. 2008 Jul 01; 7(13):2013-20. PMID: 18604178; PMCID: PMC3121316.
    18. Tawara H, Fujiuchi N, Sironi J, Martin S, Aglipay J, Ouchi M, Taga M, Chen PL, Ouchi T. Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37. Front Biosci. 2008 Jan 01; 13:240-8. PMID: 17981542.
      View in: PubMed
    19. Wang X, Chen CF, Baker PR, Chen PL, Kaiser P, Huang L. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry. 2007 Mar 20; 46(11):3553-65. PMID: 17323924.
      View in: PubMed
    20. Furuta S, Wang JM, Wei S, Jeng YM, Jiang X, Gu B, Chen PL, Lee EY, Lee WH. Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell. 2006 Jul; 10(1):13-24. PMID: 16843262.
      View in: PubMed
    21. Furuta S, Jiang X, Gu B, Cheng E, Chen PL, Lee WH. Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9176-81. PMID: 15967981; PMCID: PMC1166629.
    22. Chen PL, Liu F, Cai S, Lin X, Li A, Chen Y, Gu B, Lee EY, Lee WH. Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol Cell Biol. 2005 May; 25(9):3535-42. PMID: 15831459; PMCID: PMC1084307.
    23. Townsend PA, Cragg MS, Davidson SM, McCormick J, Barry S, Lawrence KM, Knight RA, Hubank M, Chen PL, Latchman DS, Stephanou A. STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. J Cell Sci. 2005 Apr 15; 118(Pt 8):1629-39. PMID: 15784679.
      View in: PubMed
    24. Peng A, Chen PL. NFBD1/Mdc1 mediates ATR-dependent DNA damage response. Cancer Res. 2005 Feb 15; 65(4):1158-63. PMID: 15734998.
      View in: PubMed
    25. Polci R, Peng A, Chen PL, Riley DJ, Chen Y. NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. Cancer Res. 2004 Dec 15; 64(24):8800-3. PMID: 15604234.
      View in: PubMed
    26. Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH. Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. J Biol Chem. 2004 Oct 15; 279(42):43522-9. PMID: 15294905.
      View in: PubMed
    27. Shu Z, Vijayakumar S, Chen CF, Chen PL, Lee WH. Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change. Biochemistry. 2004 Apr 27; 43(16):4781-90. PMID: 15096047.
      View in: PubMed
    28. Wu G, Jiang X, Lee WH, Chen PL. Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1. Cancer Res. 2003 May 15; 63(10):2589-95. PMID: 12750284.
      View in: PubMed
    29. Peng A, Chen PL. NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. J Biol Chem. 2003 Mar 14; 278(11):8873-6. PMID: 12551934.
      View in: PubMed
    30. Shang YL, Bodero AJ, Chen PL. NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response. J Biol Chem. 2003 Feb 21; 278(8):6323-9. PMID: 12475977.
      View in: PubMed
    31. Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH. Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation. J Biol Chem. 2002 Dec 20; 277(51):49408-16. PMID: 12386167.
      View in: PubMed
    32. Nikitin AY, Liu CY, Flesken-Nikitin A, Chen CF, Chen PL, Lee WH. Cell lineage-specific effects associated with multiple deficiencies of tumor susceptibility genes in Msh2(-/-)Rb(+/-) mice. Cancer Res. 2002 Sep 15; 62(18):5134-8. PMID: 12234974.
      View in: PubMed
    33. Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science. 2002 Sep 13; 297(5588):1837-48. PMID: 12228710.
      View in: PubMed
    34. Zhong Q, Boyer TG, Chen PL, Lee WH. Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res. 2002 Jul 15; 62(14):3966-70. PMID: 12124328.
      View in: PubMed
    35. Zhong Q, Chen CF, Chen PL, Lee WH. BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J Biol Chem. 2002 Aug 09; 277(32):28641-7. PMID: 12039951.
      View in: PubMed
    36. Zheng L, Flesken-Nikitin A, Chen PL, Lee WH. Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability. Cancer Res. 2002 May 01; 62(9):2498-502. PMID: 11980640.
      View in: PubMed
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