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Grando, Sergei A

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentDermatology
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-2713
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    5th International Symposium on Non-neuronal Acetylcholine: From Bench to Bedside
    NIH/NCATS R13TR001693Jul 1, 2017 - Jun 30, 2018
    Role: Principal Investigator
    Pemphigus &Pemphigoid: from the bench to the bedside
    NIH/NIAMS R13AR060059Jul 15, 2010 - Jun 30, 2011
    Role: Principal Investigator
    Nicotinic Receptor Ligands and Tobacco-induced Lung Cancer
    NIH/NIEHS R01ES017009May 1, 2010 - Jan 31, 2015
    Role: Principal Investigator
    Nicotinic receptor-mediated action of tobacco nitrosamines on respiratory cells
    NIH/NIEHS R21ES014384Sep 11, 2006 - Jun 30, 2010
    Role: Principal Investigator
    Can nicotinic antagonists prevent tobacco smoke-induced*
    NIH/NCI R03CA117327Aug 1, 2005 - Jul 31, 2008
    Role: Principal Investigator
    EPITHELIAL ACETYLCHOLINE IN ORAL BIOLOGY AND PATHOLOGY
    NIH/NIDCR R01DE014173Jul 1, 2001 - Mar 31, 2013
    Role: Principal Investigator
    Regulation of Keratinocyte Migration by Acetylcholine
    NIH/NIGMS R01GM062136Dec 1, 2000 - Dec 31, 2011
    Role: Principal Investigator
    CHOLINERGIC CONTROL OF KERATINOCYTE MIGRATION
    NIH/NIAMS R29AR042955May 1, 1995 - Nov 30, 2001
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Murrell DF, Peña S, Joly P, Marinovic B, Hashimoto T, Diaz LA, Sinha AA, Payne AS, Daneshpazhooh M, Eming R, Jonkman MF, Mimouni D, Borradori L, Kim SC, Yamagami J, Lehman JS, Saleh MA, Culton DA, Czernik A, Zone JJ, Fivenson D, Ujiie H, Wozniak K, Akman-Karakas A, Bernard P, Korman NJ, Caux F, Drenovska K, Prost-Squarcioni C, Vassileva S, Feldman RJ, Cardones AR, Bauer J, Ioannides D, Jedlickova H, Palisson F, Patsatsi A, Uzun S, Yayli S, Zillikens D, Amagai M, Hertl M, Schmidt E, Aoki V, Grando S, Shimizu H, Baum S, Cianchini G, Feliciani C, Iranzo P, Mascaró JM, Kowalewski C, Hall R, Groves R, Harman KE, Marinkovich MP, Maverakis E, Werth VP. Diagnosis and Management of Pemphigus: recommendations by an International Panel of Experts. J Am Acad Dermatol. 2018 Feb 10. PMID: 29438767.
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    2. Spindler V, Eming R, Schmidt E, Amagai M, Grando S, Jonkman MF, Kowalczyk AP, Müller EJ, Payne AS, Pincelli C, Sinha AA, Sprecher E, Zillikens D, Hertl M, Waschke J. Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus. J Invest Dermatol. 2018 Jan; 138(1):32-37. PMID: 29037765.
      View in: PubMed
    3. Schmidt E, Spindler V, Eming R, Amagai M, Antonicelli F, Baines JF, Belheouane M, Bernard P, Borradori L, Caproni M, Di Zenzo G, Grando S, Harman K, Jonkman MF, Koga H, Ludwig RJ, Kowalczyk AP, Müller EJ, Nishie W, Pas H, Payne AS, Sadik CD, Seppänen A, Setterfield J, Shimizu H, Sinha AA, Sprecher E, Sticherling M, Ujiie H, Zillikens D, Hertl M, Waschke J. Meeting Report of the Pathogenesis of Pemphigus and Pemphigoid Meeting in Munich, September 2016. J Invest Dermatol. 2017 Jun; 137(6):1199-1203. PMID: 28390814.
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    4. Amber KT, Panganiban CM, Korta D, Feraudy S, Kelly KM, Grando S. A case report of bullous pemphigoid associated with a melanoma and review of the literature. Melanoma Res. 2017 02; 27(1):65-67. PMID: 27759577.
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    5. Ahmed AR, Carrozzo M, Caux F, Cirillo N, Dmochowski M, Alonso AE, Gniadecki R, Hertl M, López-Zabalza MJ, Lotti R, Pincelli C, Pittelkow M, Schmidt E, Sinha AA, Sprecher E, Grando S. Monopathogenic vs multipathogenic explanations of pemphigus pathophysiology. Exp Dermatol. 2016 11; 25(11):839-846. PMID: 27305362.
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    6. Grando S, Pittelkow MR. Pseudo pemphigus phenotypes in mice with inactivated desmoglein 3: further insight to the complexity of pemphigus pathophysiology. Am J Pathol. 2015 Nov; 185(11):3125-7. PMID: 26506474.
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    7. Grando S, Kawashima K, Kirkpatrick CJ, Kummer W, Wessler I. Recent progress in revealing the biological and medical significance of the non-neuronal cholinergic system. Int Immunopharmacol. 2015 Nov; 29(1):1-7. PMID: 26362206.
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    8. Grando S. The mitochondrion is a common target of disease pathophysiology in pemphigus and pemphigoid. Exp Dermatol. 2015 Sep; 24(9):655-6. PMID: 26014338.
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    9. Chen Y, Chernyavsky A, Webber RJ, Grando S, Wang PH. Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris. J Biol Chem. 2015 Sep 25; 290(39):23826-37. PMID: 26260795; PMCID: PMC4583029.
    10. Chernyavsky AI, Shchepotin IB, Grando S. Mechanisms of growth-promoting and tumor-protecting effects of epithelial nicotinic acetylcholine receptors. Int Immunopharmacol. 2015 Nov; 29(1):36-44. PMID: 26071223.
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    11. He Y, Shimoda M, Ono Y, Villalobos IB, Mitra A, Konia T, Grando S, Zone JJ, Maverakis E. Persistence of Autoreactive IgA-Secreting B Cells Despite Multiple Immunosuppressive Medications Including Rituximab. JAMA Dermatol. 2015 Jun; 151(6):646-50. PMID: 25901938.
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    12. Chernyavsky A, Chen Y, Wang PH, Grando S. Pemphigus vulgaris antibodies target the mitochondrial nicotinic acetylcholine receptors that protect keratinocytes from apoptolysis. Int Immunopharmacol. 2015 Nov; 29(1):76-80. PMID: 25998908.
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    13. Kalantari-Dehaghi M, Parnell EA, Armand T, Bernard HU, Grando S. The nicotinic acetylcholine receptor-mediated reciprocal effects of the tobacco nitrosamine NNK and SLURP-1 on human mammary epithelial cells. Int Immunopharmacol. 2015 Nov; 29(1):99-104. PMID: 25986726.
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    14. Chernyavsky AI, Galitovskiy V, Grando S. Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression. Int Immunopharmacol. 2015 Nov; 29(1):15-20. PMID: 25957200.
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    15. Chernyavsky AI, Shchepotin IB, Galitovkiy V, Grando S. Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors. BMC Cancer. 2015 Mar 19; 15:152. PMID: 25885699; PMCID: PMC4369089.
    16. Ky C, Swasdibutra B, Khademi S, Desai S, Laquer V, Grando S. Efficacy of Intravenous Immunoglobulin Monotherapy in Patients with Cutaneous Lupus Erythematosus: Results of Proof-of-Concept Study. Dermatol Reports. 2015 Mar 16; 7(1):5804. PMID: 25918617; PMCID: PMC4387332.
    17. Murrell DF, Marinovic B, Caux F, Prost C, Ahmed R, Wozniak K, Amagai M, Bauer J, Beissert S, Borradori L, Culton D, Fairley JA, Fivenson D, Jonkman MF, Marinkovich MP, Woodley D, Zone J, Aoki V, Bernard P, Bruckner-Tuderman L, Cianchini G, Venning V, Diaz L, Eming R, Grando S, Hall RP, Hashimoto T, Herrero-González JE, Hertl M, Joly P, Karpati S, Kim J, Chan Kim S, Korman NJ, Kowalewski C, Lee SE, Rubenstein DR, Sprecher E, Yancey K, Zambruno G, Zillikens D, Doan S, Daniel BS, Werth VP. Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts. J Am Acad Dermatol. 2015 Jan; 72(1):168-74. PMID: 25443626.
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    18. Chernyavsky AI, Galitovskiy V, Shchepotin IB, Jester JV, Grando S. The acetylcholine signaling network of corneal epithelium and its role in regulation of random and directional migration of corneal epithelial cells. Invest Ophthalmol Vis Sci. 2014 Sep 30; 55(10):6921-33. PMID: 25270189.
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    19. Tang W, Kuruvilla SA, Galitovskiy V, Pan ML, Grando S, Mukherjee J. Targeting histone deacetylase in lung cancer for early diagnosis: (18)F-FAHA PET/CT imaging of NNK-treated A/J mice model. Am J Nucl Med Mol Imaging. 2014; 4(4):324-32. PMID: 24982818; PMCID: PMC4074498.
    20. Grando S. Connections of nicotine to cancer. Nat Rev Cancer. 2014 06; 14(6):419-29. PMID: 24827506.
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    21. Chernyavsky AI, Galitovskiy V, Shchepotin IB, Grando S. Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and SLURP-2 on human intestinal epithelial cells and immunocytes. Biomed Res Int. 2014; 2014:609086. PMID: 24877120; PMCID: PMC4024406.
    22. Phillips C, Kalantari-Dehaghi M, Marchenko S, Chernyavsky AI, Galitovskiy V, Gindi V, Chun S, Paslin D, Grando S. Is Grover's disease an autoimmune dermatosis? Exp Dermatol. 2013 Dec; 22(12):781-4. PMID: 24131368.
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    23. Kalantari-Dehaghi M, Chen Y, Deng W, Chernyavsky A, Marchenko S, Wang PH, Grando S. Mechanisms of mitochondrial damage in keratinocytes by pemphigus vulgaris antibodies. J Biol Chem. 2013 Jun 07; 288(23):16916-25. PMID: 23599429; PMCID: PMC3675624.
    24. Kalantari-Dehaghi M, Anhalt GJ, Camilleri MJ, Chernyavsky AI, Chun S, Felgner PL, Jasinskas A, Leiferman KM, Liang L, Marchenko S, Nakajima-Sasaki R, Pittelkow MR, Zone JJ, Grando S. Pemphigus vulgaris autoantibody profiling by proteomic technique. PLoS One. 2013; 8(3):e57587. PMID: 23505434.
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    25. Stegemann A, Sindrilaru A, Eckes B, del Rey A, Heinick A, Schulte JS, Müller FU, Grando S, Fiebich BL, Scharffetter-Kochanek K, Luger TA, Böhm M. Tropisetron suppresses collagen synthesis in skin fibroblasts via a7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model. Arthritis Rheum. 2013 Mar; 65(3):792-804. PMID: 23440693.
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    26. Grando S, Kawashima K, Kirkpatrick CJ, Meurs H, Wessler I. The non-neuronal cholinergic system: basic science, therapeutic implications and new perspectives. Life Sci. 2012 Nov 27; 91(21-22):969-72. PMID: 23141771.
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    27. Gordon W, Galitovskiy V, Edwards R, Andersen B, Grando S. The tobacco carcinogen nitrosamine induces a differential gene expression response in tumour susceptible A/J and resistant C3H mouse lungs. Eur J Cancer. 2013 Feb; 49(3):725-33. PMID: 23010150.
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    28. Chernyavsky AI, Marchenko S, Phillips C, Grando S. Auto/paracrine nicotinergic peptides participate in cutaneous stress response to wounding. Dermatoendocrinol. 2012 Jul 01; 4(3):324-30. PMID: 23467535; PMCID: PMC3583894.
    29. Galitovskiy V, Chernyavsky AI, Edwards RA, Grando S. Muscle sarcomas and alopecia in A/J mice chronically treated with nicotine. Life Sci. 2012 Nov 27; 91(21-22):1109-12. PMID: 22521759; PMCID: PMC3407298.
    30. Calleja-Macias I, Osann K, Remedios-Chan M, Barrera-Saldana HA, Illades-Aguiar B, Anton-Culver H, Chikova AK, Grando S, Bernard HU. Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia. Life Sci. 2012 Nov 27; 91(21-22):1099-102. PMID: 22406075; PMCID: PMC4051415.
    31. Parnell EA, Calleja-Macias IE, Kalantari M, Grando S, Bernard HU. Muscarinic cholinergic signaling in cervical cancer cells affects cell motility via ERK1/2 signaling. Life Sci. 2012 Nov 27; 91(21-22):1093-8. PMID: 22406505.
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    32. Ortiz A, Grando S. Smoking and the skin. Int J Dermatol. 2012 Mar; 51(3):250-62. PMID: 22348557.
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    33. Kalantari-Dehaghi M, Bernard HU, Grando S. Reciprocal effects of NNK and SLURP-1 on oncogene expression in target epithelial cells. Life Sci. 2012 Nov 27; 91(21-22):1122-5. PMID: 22369755; PMCID: PMC3371149.
    34. Chikova A, Bernard HU, Shchepotin IB, Grando S. New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer. Life Sci. 2012 Nov 27; 91(21-22):1103-8. PMID: 22280835; PMCID: PMC3341501.
    35. Grando S. Muscarinic receptor agonists and antagonists: effects on keratinocyte functions. Handb Exp Pharmacol. 2012; (208):429-50. PMID: 22222709.
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    36. Chernyavsky AI, Kalantari-Dehaghi M, Phillips C, Marchenko S, Grando S. Novel cholinergic peptides SLURP-1 and -2 regulate epithelialization of cutaneous and oral wounds. Wound Repair Regen. 2012 Jan-Feb; 20(1):103-13. PMID: 22168155; PMCID: PMC3266983.
    37. Chikova A, Grando S. Naturally occurring variants of human ?9 nicotinic receptor differentially affect bronchial cell proliferation and transformation. PLoS One. 2011; 6(11):e27978. PMID: 22125646; PMCID: PMC3220719.
    38. Murrell DF, Daniel BS, Joly P, Borradori L, Amagai M, Hashimoto T, Caux F, Marinovic B, Sinha AA, Hertl M, Bernard P, Sirois D, Cianchini G, Fairley JA, Jonkman MF, Pandya AG, Rubenstein D, Zillikens D, Payne AS, Woodley D, Zambruno G, Aoki V, Pincelli C, Diaz L, Hall RP, Meurer M, Mascaro JM, Schmidt E, Shimizu H, Zone J, Swerlick R, Mimouni D, Culton D, Lipozencic J, Bince B, Grando S, Bystryn JC, Werth VP. Definitions and outcome measures for bullous pemphigoid: recommendations by an international panel of experts. J Am Acad Dermatol. 2012 Mar; 66(3):479-85. PMID: 22056920; PMCID: PMC3883429.
    39. Grando S. Pemphigus autoimmunity: hypotheses and realities. Autoimmunity. 2012 Feb; 45(1):7-35. PMID: 21939410; PMCID: PMC3251002.
    40. Czernik A, Toosi S, Bystryn JC, Grando S. Intravenous immunoglobulin in the treatment of autoimmune bullous dermatoses: an update. Autoimmunity. 2012 Feb; 45(1):111-8. PMID: 21923613.
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    41. Grando S, Laquer VT, Le HM. Sirolimus for acute pemphigus vulgaris: a case report and discussion of dualistic action providing for both immunosuppression and keratinocyte protection. J Am Acad Dermatol. 2011 Sep; 65(3):684-6. PMID: 21839342.
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    42. Czernik A, Camilleri M, Pittelkow MR, Grando S. Paraneoplastic autoimmune multiorgan syndrome: 20 years after. Int J Dermatol. 2011 Aug; 50(8):905-14. PMID: 21781058.
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    43. Galitovskiy V, Qian J, Chernyavsky AI, Marchenko S, Gindi V, Edwards RA, Grando S. Cytokine-induced alterations of a7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis. J Immunol. 2011 Sep 01; 187(5):2677-87. PMID: 21784975; PMCID: PMC4260719.
    44. Schultz HY, Diaz LA, Sirois DA, Werth VP, Grando S. Generating consensus research goals and treatment strategies for pemphigus and pemphigoid: The 2010 JC Bystryn Pemphigus and Pemphigoid Meeting. J Invest Dermatol. 2011 Jul; 131(7):1395-9. PMID: 21673705.
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    45. Kalantari-Dehaghi M, Molina DM, Farhadieh M, Morrow WJ, Liang X, Felgner PL, Grando S. New targets of pemphigus vulgaris antibodies identified by protein array technology. Exp Dermatol. 2011 Feb; 20(2):154-6. PMID: 21255096.
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    46. Koval L, Lykhmus O, Zhmak M, Khruschov A, Tsetlin V, Magrini E, Viola A, Chernyavsky A, Qian J, Grando S, Komisarenko S, Skok M. Differential involvement of a4ß2, a7 and a9a10 nicotinic acetylcholine receptors in B lymphocyte activation in vitro. Int J Biochem Cell Biol. 2011 Apr; 43(4):516-24. PMID: 21146628.
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    47. Grando S, Holubar K, Schwartz RA. Jean-Claude Bystryn 1938-2010. An obituary. Exp Dermatol. 2011 Mar; 20(3):293-6. PMID: 21323751.
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    48. Chernyavsky AI, Arredondo J, Galitovskiy V, Qian J, Grando S. Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases. Am J Physiol Cell Physiol. 2010 Nov; 299(5):C903-11. PMID: 20660165; PMCID: PMC2980298.
    49. Chernyavsky AI, Arredondo J, Skok M, Grando S. Auto/paracrine control of inflammatory cytokines by acetylcholine in macrophage-like U937 cells through nicotinic receptors. Int Immunopharmacol. 2010 Mar; 10(3):308-15. PMID: 20004742; PMCID: PMC2829366.
    50. Marchenko S, Chernyavsky AI, Arredondo J, Gindi V, Grando S. Antimitochondrial autoantibodies in pemphigus vulgaris: a missing link in disease pathophysiology. J Biol Chem. 2010 Feb 05; 285(6):3695-704. PMID: 20007702; PMCID: PMC2823510.
    51. Arredondo J, Omelchenko D, Chernyavsky AI, Qian J, Skok M, Grando S. Functional role of the nicotinic arm of the acetylcholine regulatory axis in human B-cell lines. J Exp Pharmacol. 2009; 1:1-7. PMID: 27186084; PMCID: PMC4863279.
    52. Grando S, Bystryn JC, Chernyavsky AI, Frusic-Zlotkin M, Gniadecki R, Lotti R, Milner Y, Pittelkow MR, Pincelli C. Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis. Exp Dermatol. 2009 Sep; 18(9):764-70. PMID: 19555352.
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    53. Chernyavsky AI, Arredondo J, Qian J, Galitovskiy V, Grando S. Coupling of ionic events to protein kinase signaling cascades upon activation of alpha7 nicotinic receptor: cooperative regulation of alpha2-integrin expression and Rho kinase activity. J Biol Chem. 2009 Aug 14; 284(33):22140-8. PMID: 19549780; PMCID: PMC2755938.
    54. Hsu DK, Chernyavsky AI, Chen HY, Yu L, Grando S, Liu FT. Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells. J Invest Dermatol. 2009 Mar; 129(3):573-83. PMID: 18843294; PMCID: PMC2645233.
    55. Arredondo J, Chernyavsky AI, Jolkovsky DL, Pinkerton KE, Grando S. Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke. FASEB J. 2008 May; 22(5):1356-68. PMID: 18450646.
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    56. Grando S. Basic and clinical aspects of non-neuronal acetylcholine: biological and clinical significance of non-canonical ligands of epithelial nicotinic acetylcholine receptors. J Pharmacol Sci. 2008 Feb; 106(2):174-9. PMID: 18285656.
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    57. Michael D, Grando S. Novel mechanism for therapeutic action of IVIg in autoimmune blistering dermatoses. Curr Dir Autoimmun. 2008; 10:333-43. PMID: 18460894.
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    58. Chernyavsky AI, Arredondo J, Piser T, Karlsson E, Grando S. Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis. J Biol Chem. 2008 Feb 08; 283(6):3401-8. PMID: 18073210.
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    59. Fujii YX, Fujigaya H, Moriwaki Y, Misawa H, Kasahara T, Grando S, Kawashima K. Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice. J Neuroimmunol. 2007 Sep; 189(1-2):69-74. PMID: 17675251.
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    60. Chernyavsky AI, Arredondo J, Vetter DE, Grando S. Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelialization. Exp Cell Res. 2007 Oct 01; 313(16):3542-55. PMID: 17706194; PMCID: PMC2682983.
    61. Arredondo J, Chernyavsky AI, Grando S. Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells. Biochem Pharmacol. 2007 Oct 15; 74(8):1315-9. PMID: 17643396; PMCID: PMC2046218.
    62. Song P, Sekhon HS, Lu A, Arredondo J, Sauer D, Gravett C, Mark GP, Grando S, Spindel ER. M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res. 2007 Apr 15; 67(8):3936-44. PMID: 17440109.
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    63. Grando S, Kawashima K, Kirkpatrick CJ, Wessler I. Recent progress in understanding the non-neuronal cholinergic system in humans. Life Sci. 2007 May 30; 80(24-25):2181-5. PMID: 17467010.
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    64. Chernyavsky AI, Arredondo J, Kitajima Y, Sato-Nagai M, Grando S. Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens. J Biol Chem. 2007 May 04; 282(18):13804-12. PMID: 17344213.
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    65. Hasse S, Chernyavsky AI, Grando S, Paus R. The M4 muscarinic acetylcholine receptor plays a key role in the control of murine hair follicle cycling and pigmentation. Life Sci. 2007 May 30; 80(24-25):2248-52. PMID: 17346754; PMCID: PMC2017094.
    66. Bschleipfer T, Schukowski K, Weidner W, Grando S, Schwantes U, Kummer W, Lips KS. Expression and distribution of cholinergic receptors in the human urothelium. Life Sci. 2007 May 30; 80(24-25):2303-7. PMID: 17335853.
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    67. Zarghooni S, Wunsch J, Bodenbenner M, Brüggmann D, Grando S, Schwantes U, Wess J, Kummer W, Lips KS. Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium. Life Sci. 2007 May 30; 80(24-25):2308-13. PMID: 17337281.
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    68. Biallas S, Wilker S, Lips KS, Kummer W, Grando S, Padberg W, Grau V. Immunohistochemical detection of nicotinic acetylcholine receptor subunits alpha9 and alpha10 in rat lung isografts and allografts. Life Sci. 2007 May 30; 80(24-25):2286-9. PMID: 17331545.
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    69. Grau V, Wilker S, Hartmann P, Lips KS, Grando S, Padberg W, Fehrenbach H, Kummer W. Administration of keratinocyte growth factor (KGF) modulates the pulmonary expression of nicotinic acetylcholine receptor subunits alpha7, alpha9 and alpha10. Life Sci. 2007 May 30; 80(24-25):2290-3. PMID: 17291541.
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    70. Arredondo J, Chernyavsky AI, Jolkovsky DL, Pinkerton KE, Grando S. Receptor-mediated tobacco toxicity: alterations of the NF-kappaB expression and activity downstream of alpha7 nicotinic receptor in oral keratinocytes. Life Sci. 2007 May 30; 80(24-25):2191-4. PMID: 17291542; PMCID: PMC1973165.
    71. Arredondo J, Chernyavsky AI, Grando S. SLURP-1 and -2 in normal, immortalized and malignant oral keratinocytes. Life Sci. 2007 May 30; 80(24-25):2243-7. PMID: 17280689; PMCID: PMC1929016.
    72. Orlov MD, Chernyavsky AI, Arredondo J, Grando S. Synergistic actions of pemphigus vulgaris IgG, Fas-ligand and tumor necrosis factor-alpha during induction of basal cell shrinkage and acantholysis. Autoimmunity. 2006 Nov; 39(7):557-62. PMID: 17101499.
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    73. Billet SE, Grando S, Pittelkow MR. Paraneoplastic autoimmune multiorgan syndrome: review of the literature and support for a cytotoxic role in pathogenesis. Autoimmunity. 2006 Nov; 39(7):617-30. PMID: 17101506.
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    74. Grando S. Pemphigus in the XXI century: new life to an old story. Autoimmunity. 2006 Nov; 39(7):521-30. PMID: 17135055.
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    75. Arredondo J, Chernyavsky AI, Jolkovsky DL, Pinkerton KE, Grando S. Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes. FASEB J. 2006 Oct; 20(12):2093-101. PMID: 17012261.
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    76. Grando S, Pittelkow MR, Schallreuter KU. Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical significance. J Invest Dermatol. 2006 Sep; 126(9):1948-65. PMID: 16912692.
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    77. Arredondo J, Chernyavsky AI, Grando S. The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells. J Cancer Res Clin Oncol. 2006 Oct; 132(10):653-63. PMID: 16835749.
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    78. Arredondo J, Chernyavsky AI, Jolkovsky DL, Webber RJ, Grando S. SLURP-2: A novel cholinergic signaling peptide in human mucocutaneous epithelium. J Cell Physiol. 2006 Jul; 208(1):238-45. PMID: 16575903.
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    79. Arredondo J, Chernyavsky AI, Grando S. Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells. Cancer Biol Ther. 2006 May; 5(5):511-7. PMID: 16582591.
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    80. Schwartz RA, Grando S. Pemphigus exacerbators. Skinmed. 2006 May-Jun; 5(3):109-10. PMID: 16687977.
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    81. Grando S. Cholinergic control of epidermal cohesion. Exp Dermatol. 2006 Apr; 15(4):265-82. PMID: 16512874.
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    82. Kong J, Grando S, Li YC. Regulation of IL-1 family cytokines IL-1alpha, IL-1 receptor antagonist, and IL-18 by 1,25-dihydroxyvitamin D3 in primary keratinocytes. J Immunol. 2006 Mar 15; 176(6):3780-7. PMID: 16517748.
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    83. Bystryn JC, Grando S. A novel explanation for acantholysis in pemphigus vulgaris: the basal cell shrinkage hypothesis. J Am Acad Dermatol. 2006 Mar; 54(3):513-6. PMID: 16488306.
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    84. Lips KS, König P, Schätzle K, Pfeil U, Krasteva G, Spies M, Haberberger RV, Grando S, Kummer W. Coexpression and spatial association of nicotinic acetylcholine receptor subunits alpha7 and alpha10 in rat sympathetic neurons. J Mol Neurosci. 2006; 30(1-2):15-6. PMID: 17192608.
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    85. Arredondo J, Chernyavsky AI, Karaouni A, Grando S. Novel mechanisms of target cell death and survival and of therapeutic action of IVIg in Pemphigus. Am J Pathol. 2005 Dec; 167(6):1531-44. PMID: 16314468; PMCID: PMC1613205.
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    87. Chernyavsky AI, Arredondo J, Karlsson E, Wessler I, Grando S. The Ras/Raf-1/MEK1/ERK signaling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration. J Biol Chem. 2005 Nov 25; 280(47):39220-8. PMID: 16150734.
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    88. Arredondo J, Chernyavsky AI, Marubio LM, Beaudet AL, Jolkovsky DL, Pinkerton KE, Grando S. Receptor-mediated tobacco toxicity: regulation of gene expression through alpha3beta2 nicotinic receptor in oral epithelial cells. Am J Pathol. 2005 Feb; 166(2):597-613. PMID: 15681842; PMCID: PMC1602318.
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    90. Chernyavsky AI, Arredondo J, Wess J, Karlsson E, Grando S. Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization through M3 and M4 muscarinic receptors. J Cell Biol. 2004 Jul 19; 166(2):261-72. PMID: 15263021; PMCID: PMC2172302.
    91. Nguyen VT, Chernyavsky AI, Arredondo J, Bercovich D, Orr-Urtreger A, Vetter DE, Wess J, Beaudet AL, Kitajima Y, Grando S. Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes. Exp Cell Res. 2004 Apr 01; 294(2):534-49. PMID: 15023540.
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    92. Nguyen VT, Arredondo J, Chernyavsky AI, Pittelkow MR, Kitajima Y, Grando S. Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists. Arch Dermatol. 2004 Mar; 140(3):327-34. PMID: 15023776.
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    93. Grando S. New approaches to the treatment of pemphigus. J Investig Dermatol Symp Proc. 2004 Jan; 9(1):84-91. PMID: 14870992.
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    94. Nguyen VT, Arredondo J, Chernyavsky AI, Kitajima Y, Pittelkow M, Grando S. Pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocytes. J Biol Chem. 2004 Jan 16; 279(3):2135-46. PMID: 14600150.
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    95. Arredondo J, Nguyen VT, Chernyavsky AI, Bercovich D, Orr-Urtreger A, Vetter DE, Grando S. Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis. Life Sci. 2003 Mar 28; 72(18-19):2063-7. PMID: 12628457.
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    96. Chernyavsky AI, Nguyen VT, Arredondo J, Ndoye A, Zia S, Wess J, Grando S. The M4 muscarinic receptor-selective effects on keratinocyte crawling locomotion. Life Sci. 2003 Mar 28; 72(18-19):2069-73. PMID: 12628458.
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    97. Nguyen VT, Arredondo J, Chernyavsky AI, Kitajima Y, Grando S. Keratinocyte acetylcholine receptors regulate cell adhesion. Life Sci. 2003 Mar 28; 72(18-19):2081-5. PMID: 12628460.
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    98. Grando S, Kawashima K, Wessler I. Introduction: the non-neuronal cholinergic system in humans. Life Sci. 2003 Mar 28; 72(18-19):2009-12. PMID: 12628450.
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    99. Grando S. Mucocutaneous cholinergic system is targeted in mustard-induced vesication. Life Sci. 2003 Mar 28; 72(18-19):2135-44. PMID: 12628470.
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    100. Arredondo J, Hall LL, Ndoye A, Nguyen VT, Chernyavsky AI, Bercovich D, Orr-Urtreger A, Beaudet AL, Grando S. Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine. Lab Invest. 2003 Feb; 83(2):207-25. PMID: 12594236.
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    101. Grando S, Grando AA, Glukhenky BT, Doguzov V, Nguyen VT, Holubar K. History and clinical significance of mechanical symptoms in blistering dermatoses: a reappraisal. J Am Acad Dermatol. 2003 Jan; 48(1):86-92. PMID: 12522376.
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