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Kalpna Gupta

Title(s)Professor In Residence, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Collapse Research 
    Collapse research activities and funding
    Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system
    NIH R01CA263806Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    Summer Mentoring and Research Training (SMART)
    NIH T35DK128788Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Targeting mechanisms contributing to vascular dysfunction and pain in sickle cell disease
    NIH R01HL147562Apr 4, 2019 - Mar 31, 2023
    Role: Principal Investigator
    Cannabinoid-based therapy and approaches to quantify pain in sickle cell disease
    NIH U01HL117664Aug 15, 2013 - May 31, 2019
    Role: Principal Investigator
    Characteristics and mechanisms of pain in sickle cell disease
    NIH R01HL103733Sep 5, 2010 - Aug 31, 2016
    Role: Principal Investigator
    Opioid and Breast Cancer Growth and Metastasis
    NIH R01CA109582Apr 1, 2005 - Feb 29, 2012
    Role: Principal Investigator
    Opioid Activity in Endothelium in Sickle Cell Disease
    NIH R01HL068802Apr 1, 2002 - May 31, 2014
    Role: Principal Investigator
    Cannabinoid Modulation of Hyperalgesia
    NIH R01HL135895Feb 3, 2000 - Jun 30, 2021
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Anti-sickling efficacy and safety of Sailin-HbS, an indigenous Ayurvedic formulation. Blood Cells Mol Dis. 2025 Sep 03; 116:102956. Bhatt S, Bhansali A, Rajesh AS, Meher S, Jena RK, Dash BP, Panda PK, Gupta K, Kundu S. PMID: 40934727.
      View in: PubMed   Mentions:    Fields:    
    2. Biomarker signatures for sickle cell pain. Blood Adv. 2025 Aug 12; 9(15):3821-3823. Gupta K, Kumaresan V. PMID: 40711774; PMCID: PMC12372969.
      View in: PubMed   Mentions:    Fields:    
    3. Breaking the vicious cycle in sickle cell disease: Redox stress impairs red blood cell rheology and promotes lung vasocongestion. Free Radic Biol Med. 2025 Oct; 238:563-568. Pant T, Li K, Jones DW, Day BW, Naylor S, Gupta K, Pritchard KA. PMID: 40645460.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Neuroprotective, anti-inflammatory, and analgesic activity of palmitoylethanolamide in sickle cell mice. Blood Adv. 2025 Jun 24; 9(12):3056-3068. Argueta DA, Avalos B, Goel Y, Tran H, Fotio Y, Piomelli D, DiPatrizio NV, Gupta K. PMID: 40085960; PMCID: PMC12209929.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    5. Editorial: Current treatment strategies and integrative medicine for management of pain in sickle cell disease. Front Pain Res (Lausanne). 2025; 6:1621147. Richardson KA, McLemore GL, Powell-Roach K, Gupta K. PMID: 40557279; PMCID: PMC12186450.
      View in: PubMed   Mentions:
    6. The role of Poly-ADP ribose polymerase (PARP) enzymes in chemotherapy-induced cognitive impairments - parallels with other neurodegenerative disorders. Front Pharmacol. 2025; 16:1615843. Ordaz DA, Gupta K, Bota DA. PMID: 40552150; PMCID: PMC12183237.
      View in: PubMed   Mentions:
    7. Neuronal p38 MAPK Signaling Contributes to Cisplatin-Induced Peripheral Neuropathy. Antioxidants (Basel). 2025 Apr 08; 14(4). Goel Y, Argueta DA, Peterson K, Lomeli N, Bota DA, Gupta K. PMID: 40298791; PMCID: PMC12024185.
      View in: PubMed   Mentions: 1  
    8. Analgesic effect of simultaneously targeting multiple pain processing brain circuits in an aged humanized mouse model of chronic pain by transcranial focused ultrasound. APL Bioeng. 2025 Mar; 9(1):016108. Kim MG, Yeh CY, Yu K, Li Z, Gupta K, He B. PMID: 39990925; PMCID: PMC11846022.
      View in: PubMed   Mentions: 2  
    9. Targeting sickle cell pathobiology and pain with novel transdermal curcumin. PNAS Nexus. 2025 Feb; 4(2):pgaf053. Goel Y, Arellano MA, Fouda RT, Garcia NR, Lomeli RA, Kerr D, Argueta DA, Gupta M, Velasco GJ, Prince R, Banerjee P, Jana S, Alayash AI, Friedman JM, Gupta K. PMID: 40007577; PMCID: PMC11854080.
      View in: PubMed   Mentions: 1  
    10. N-acetylcysteine prevents cisplatin-induced cognitive impairments in an ovarian cancer rat model. Cancer Lett. 2024 Dec 19; 611:217405. Lomeli N, Pearre DC, Lepe J, Argueta DA, Arellano MA, Ricks-Oddie JL, Gupta K, Bota DA. PMID: 39706252.
      View in: PubMed   Mentions: 1     Fields:    
    11. Sickle cell disease in India: the journey and hope for the future. Hematology Am Soc Hematol Educ Program. 2024 12 06; 2024(1):1-9. Gupta K, Krishnamurti L, Jain D. PMID: 39644008; PMCID: PMC11665512.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    12. Δ9-Tetrahydrocannabinol Alleviates Hyperalgesia in a Humanized Mouse Model of Sickle Cell Disease. J Pharmacol Exp Ther. 2024 Oct 18; 391(2):174-181. Mabou Tagne A, Fotio Y, Gupta K, Piomelli D. PMID: 38955494.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. Mast cell extracellular trap formation underlies vascular and neural injury and hyperalgesia in sickle cell disease. Life Sci Alliance. 2024 Nov; 7(11). Argueta DA, Tran H, Goel Y, Nguyen A, Nguyen J, Kiven SB, Chen C, Abdulla F, Vercellotti GM, Belcher JD, Gupta K. PMID: 39242155; PMCID: PMC11381676.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Low-intensity transcranial focused ultrasound suppresses pain by modulating pain-processing brain circuits. Blood. 2024 09 05; 144(10):1101-1115. Kim MG, Yu K, Yeh CY, Fouda R, Argueta D, Kiven S, Ni Y, Niu X, Chen Q, Kim K, Gupta K, He B. PMID: 38976875; PMCID: PMC11406192.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    15. Sickle cell disease in India: current status and progress. Lancet Haematol. 2024 May; 11(5):e322-e323. Jain D, Gupta M, Madkaikar M, Jena RK, Khargekar N, Saraf SL, Krishnamurti L, Gupta K. PMID: 38701819.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    16. Red Blood Cells as Therapeutic Target to Treat Sickle Cell Disease. Antioxid Redox Signal. 2024 06; 40(16-18):1025-1049. Bhatt S, Argueta DA, Gupta K, Kundu S. PMID: 37975291.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Colchicine reduces inflammation in a humanized transgenic murine model of sickle cell disease. Haematologica. 2024 01 01; 109(1):308-311. Fouda RT, Cherukury HM, Kiven SB, Garcia NR, Argueta DA, Velasco GJ, Gupta K, Roberts JD. PMID: 37534545; PMCID: PMC10772532.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    18. Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation. Blood. 2023 11 30; 142(22):1918-1927. Ivy ZK, Belcher JD, Khasabova IA, Chen C, Juliette JP, Abdulla F, Ruan C, Allen K, Nguyen J, Rogness VM, Beckman JD, Khasabov SG, Gupta K, Taylor RP, Simone DA, Vercellotti GM. PMID: 37774369; PMCID: PMC10731576.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    19. Crosstalk of Mast Cells and Natural Killer Cells with Neurons in Chemotherapy-Induced Peripheral Neuropathy. Int J Mol Sci. 2023 Aug 08; 24(16). Yun HD, Goel Y, Gupta K. PMID: 37628724; PMCID: PMC10454469.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Descending Facilitation of Nociceptive Transmission From the Rostral Ventromedial Medulla Contributes to Hyperalgesia in Mice with Sickle Cell Disease. Neuroscience. 2023 08 21; 526:1-12. Rogness VM, Juliette J, Khasabova IA, Gupta K, Khasabov SG, Simone DA. PMID: 37330194; PMCID: PMC10528639.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. A new era dawns on sickle cell disease in India. Indian J Med Res. 2023 06; 157(6):491-493. Kishore RR, Gupta M, Gupta K. PMID: 37530303; PMCID: PMC10466490.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Assessment of gait in mice using simplified analysis tools. Res Sq. 2023 May 05. Fouda R, Argueta D, O'Daniel K, Peterson K, Sorto T, Gupta K. PMID: 37205356; PMCID: PMC10187402.
      View in: PubMed   Mentions:
    23. Inhibition of DAGLβ as a therapeutic target for pain in sickle cell disease. Haematologica. 2023 03 01; 108(3):859-869. Khasabova IA, Gable J, Johns M, Khasabov SG, Kalyuzhny AE, Golovko MY, Golovko SA, Kiven S, Gupta K, Seybold VS, Simone DA. PMID: 35615929; PMCID: PMC9973472.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    24. Building the foundation for a community-generated national research blueprint for inherited bleeding disorders: research priorities to transform the care of people with hemophilia. Expert Rev Hematol. 2023 03; 16(sup1):19-37. Tran DQ, Benson CC, Boice JA, Chitlur M, Dunn AL, Escobar MA, Gupta K, Johnsen JM, Jorgenson J, Martin SD, Martin S, Meeks SL, Narvaez AA, Quon DV, Reding MT, Reiss UM, Savage B, Schafer K, Steiner B, Thornburg C, Volland LM, von Drygalski A. PMID: 36920859; PMCID: PMC10020869.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Cannabidiol attenuates hyperalgesia in a mouse model of sickle cell disease. Blood. 2023 01 12; 141(2):203-208. Cherukury HM, Argueta DA, Garcia N, Fouda R, Kiven S, Lei J, Sagi V, Velasco GJ, Avalos B, DiPatrizio NV, Gupta K. PMID: 36122382; PMCID: PMC9936305.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    26. An open label phase II study of safety and clinical activity of naltrexone for treatment of hormone refractory metastatic breast cancer. Invest New Drugs. 2023 02; 41(1):70-75. Vijayakumar J, Haddad T, Gupta K, Sauers J, Yee D. PMID: 36441436; PMCID: PMC10030534.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    27. Blood diseases in Africa: Redressing unjust disparities is an urgent unmet need. Am J Hematol. 2022 12; 97(12):1505-1506. Makani J, Cavazzana M, Gupta K, Nnodu O, Odame I, Tshilolo L, Ware R, Luzzatto L. PMID: 36216786.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. A model of painful vaso-occlusive crisis in mice with sickle cell disease. Blood. 2022 10 20; 140(16):1826-1830. Khasabova II, Juliette J, Rogness VM, Khasabov SG, Golovko MY, Golovko SA, Kiven S, Gupta K, Belcher JD, Vercellotti GM, Seybold VS, Simone DA. PMID: 35960856; PMCID: PMC9837430.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    29. Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease. Front Oncol. 2022; 12:969429. Sargur Madabushi S, Fouda R, Ghimire H, Abdelhamid AMH, Lim JE, Vishwasrao P, Kiven S, Brooks J, Zuro D, Rosenthal J, Guha C, Gupta K, Hui SK. PMID: 36147914; PMCID: PMC9485604.
      View in: PubMed   Mentions: 3  
    30. Pain in Hemophilia: Unexplored Role of Oxidative Stress. Antioxidants (Basel). 2022 Jun 03; 11(6). Fouda R, Argueta DA, Gupta K. PMID: 35740010; PMCID: PMC9220316.
      View in: PubMed   Mentions: 3  
    31. Endoplasmic Reticulum Stress in Chemotherapy-Induced Peripheral Neuropathy: Emerging Role of Phytochemicals. Antioxidants (Basel). 2022 Jan 28; 11(2). Goel Y, Fouda R, Gupta K. PMID: 35204148; PMCID: PMC8868275.
      View in: PubMed   Mentions: 9  
    32. Longitudinal Preclinical Imaging Characterizes Extracellular Drug Accumulation After Radiation Therapy in the Healthy and Leukemic Bone Marrow Vascular Microenvironment. Int J Radiat Oncol Biol Phys. 2022 03 15; 112(4):951-963. Brooks J, Zuro D, Song JY, Madabushi SS, Sanchez JF, Guha C, Kortylewski M, Chen BT, Gupta K, Storme G, Froelich J, Hui SK. PMID: 34767936; PMCID: PMC9038217.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    33. Pain in sickle cell disease: current and potential translational therapies. Transl Res. 2021 08; 234:141-158. Sagi V, Mittal A, Tran H, Gupta K. PMID: 33711512; PMCID: PMC8217144.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    34. Cognitive complications of cancer and cancer-related treatments - Novel paradigms. Neurosci Lett. 2021 04 01; 749:135720. Lomeli N, Lepe J, Gupta K, Bota DA. PMID: 33582187; PMCID: PMC8423125.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    35. Diet and companionship modulate pain via a serotonergic mechanism. Sci Rep. 2021 02 01; 11(1):2330. Tran H, Sagi V, Jarrett S, Palzer EF, Badgaiyan RD, Gupta K. PMID: 33526805; PMCID: PMC7851147.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    36. β-endorphin at the intersection of pain and cancer progression: Preclinical evidence. Neurosci Lett. 2021 01 23; 744:135601. Argueta DA, Aich A, Lei J, Kiven S, Nguyen A, Wang Y, Gu J, Zhao W, Gupta K. PMID: 33387660; PMCID: PMC7837276.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    37. Considerations for Cannabis Use to Treat Pain in Sickle Cell Disease. J Clin Med. 2020 Dec 01; 9(12). Argueta DA, Aich A, Muqolli F, Cherukury H, Sagi V, DiPatrizio NV, Gupta K. PMID: 33271850; PMCID: PMC7761429.
      View in: PubMed   Mentions: 6  
    38. Bartonella henselae infection induces a persistent mechanical hypersensitivity in mice. Rev Inst Med Trop Sao Paulo. 2020; 62:e79. Vieira-Damiani G, Almeida AR, Silva MN, Lania BG, Soares TCB, Drummond MR, Lins KA, Ericson M, Gupta K, Velho PENF. PMID: 33146308; PMCID: PMC7608073.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    39. Spatiotemporal Alterations in Gait in Humanized Transgenic Sickle Mice. Front Immunol. 2020; 11:561947. Kiven S, Wang Y, Aich A, Argueta DA, Lei J, Sagi V, Tennakoon M, Bedros SJ, Lambrecht N, Gupta K. PMID: 33178189; PMCID: PMC7593487.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    40. Self-Assembled 3D Nanosplit Rings for Plasmon-Enhanced Optofluidic Sensing. Nano Lett. 2020 09 09; 20(9):6697-6705. Dai C, Lin Z, Agarwal K, Mikhael C, Aich A, Gupta K, Cho JH. PMID: 32808792.
      View in: PubMed   Mentions: 4     Fields:    
    41. Heme Causes Pain in Sickle Mice via Toll-Like Receptor 4-Mediated Reactive Oxygen Species- and Endoplasmic Reticulum Stress-Induced Glial Activation. Antioxid Redox Signal. 2021 02 01; 34(4):279-293. Lei J, Paul J, Wang Y, Gupta M, Vang D, Thompson S, Jha R, Nguyen J, Valverde Y, Lamarre Y, Jones MK, Gupta K. PMID: 32729340; PMCID: PMC7821434.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    42. Effect of Inhaled Cannabis for Pain in Adults With Sickle Cell Disease: A Randomized Clinical Trial. JAMA Netw Open. 2020 07 01; 3(7):e2010874. Abrams DI, Couey P, Dixit N, Sagi V, Hagar W, Vichinsky E, Kelly ME, Connett JE, Gupta K. PMID: 32678452; PMCID: PMC7368173.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    43. Integrative approaches to treating pain in sickle cell disease: Pre-clinical and clinical evidence. Complement Ther Med. 2020 Jun; 51:102394. Sagi V, Argueta DA, Kiven S, Gupta K. PMID: 32507420; PMCID: PMC7306403.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    44. A Balanced Approach for Cannabidiol Use in Chronic Pain. Front Pharmacol. 2020; 11:561. Argueta DA, Ventura CM, Kiven S, Sagi V, Gupta K. PMID: 32425793; PMCID: PMC7204604.
      View in: PubMed   Mentions: 25  
    45. Reply to Boland and Bennett. Pain. 2020 04; 161(4):875-876. Novy DM, Nelson DV, Koyyalagunta D, Cata JP, Gupta P, Gupta K. PMID: 32195786.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    46. Pain, opioid therapy, and survival: a needed discussion. Pain. 2020 03; 161(3):496-501. Novy DM, Nelson DV, Koyyalagunta D, Cata JP, Gupta P, Gupta K. PMID: 31693537; PMCID: PMC7017938.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    47. Prevalence of Bartonella spp. Infection in Patients with Sickle Cell Disease. Vector Borne Zoonotic Dis. 2020 07; 20(7):509-512. Soares TCB, Isaias GAB, Almeida AR, Drummond MR, da Silva MN, Lania BG, Vieira-Damiani G, Saad STO, Ericson ME, Gupta K, Velho PENF. PMID: 32013778; PMCID: PMC7336878.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    48. Significant Quantitative Differences in Orexin Neuronal Activation After Pain Assessments in an Animal Model of Sickle Cell Disease. Front Mol Biosci. 2020; 7:5. Richardson K, Sweatt N, Tran H, Apprey V, Uthayathas S, Taylor R, Gupta K. PMID: 32118032; PMCID: PMC7025496.
      View in: PubMed   Mentions: 1  
    49. End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain. Blood Adv. 2019 12 10; 3(23):3982-4001. Farrell AT, Panepinto J, Carroll CP, Darbari DS, Desai AA, King AA, Adams RJ, Barber TD, Brandow AM, DeBaun MR, Donahue MJ, Gupta K, Hankins JS, Kameka M, Kirkham FJ, Luksenburg H, Miller S, Oneal PA, Rees DC, Setse R, Sheehan VA, Strouse J, Stucky CL, Werner EM, Wood JC, Zempsky WT. PMID: 31809538; PMCID: PMC6963237.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    50. Editorial: Mast Cells in Itch, Pain and Neuro-Inflammation. Front Cell Neurosci. 2019; 13:521. Giniatullin R, Gupta K, Theoharides T. PMID: 31849611; PMCID: PMC6901903.
      View in: PubMed   Mentions: 4  
    51. Substance P modulates electroacupuncture analgesia in humanized mice with sickle cell disease. J Pain Res. 2019; 12:2419-2426. Wang Y, Lei J, Jha RK, Kiven S, Gupta K. PMID: 31447579; PMCID: PMC6682765.
      View in: PubMed   Mentions: 8  
    52. Pain and sickle cell disease. Curr Opin Hematol. 2019 05; 26(3):131-138. Aich A, Jones MK, Gupta K. PMID: 30893088.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    53. Morphine promotes neovascularizing retinopathy in sickle transgeneic mice. Blood Adv. 2019 04 09; 3(7):1073-1083. Gupta K, Chen C, Lutty GA, Hebbel RP. PMID: 30944099; PMCID: PMC6457224.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    54. Effect of chronic opioid therapy on pain and survival in a humanized mouse model of sickle cell disease. Blood Adv. 2019 03 26; 3(6):869-873. Tran H, Sagi V, Leonce Song-Naba W, Wang Y, Mittal A, Lamarre Y, Zhang L, Gupta K. PMID: 30885998; PMCID: PMC6436015.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    55. Mast Cell Neural Interactions in Health and Disease. Front Cell Neurosci. 2019; 13:110. Mittal A, Sagi V, Gupta M, Gupta K. PMID: 30949032; PMCID: PMC6435484.
      View in: PubMed   Mentions: 35  
    56. Sensitization of nociceptors by prostaglandin E2-glycerol contributes to hyperalgesia in mice with sickle cell disease. Blood. 2019 05 02; 133(18):1989-1998. Khasabova IA, Uhelski M, Khasabov SG, Gupta K, Seybold VS, Simone DA. PMID: 30796025; PMCID: PMC6497514.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    57. Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium. Front Cell Neurosci. 2019; 13:56. Tran H, Mittal A, Sagi V, Luk K, Nguyen A, Gupta M, Nguyen J, Lamarre Y, Lei J, Guedes A, Gupta K. PMID: 30837844; PMCID: PMC6389721.
      View in: PubMed   Mentions: 22  
    58. Diet and gender influence survival of transgenic Berkley sickle cell mice. Haematologica. 2019 08; 104(8):e331-e334. Jahagirdar OB, Mittal AM, Song-Naba WL, Jha R, Kiven SB, Thompson ST, Connett JE, Gupta K. PMID: 30765475; PMCID: PMC6669136.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    59. Immune cell neural interactions and their contributions to sickle cell disease. Neurosci Lett. 2019 04 23; 699:167-171. Sagi V, Mittal A, Gupta M, Gupta K. PMID: 30738871.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    60. Excessive inflammation portends complications: Wound cytokines and head and neck surgery outcomes. Laryngoscope. 2019 07; 129(7):E238-E246. Lassig AAD, Lindgren BR, Itabiyi R, Joseph AM, Gupta K. PMID: 30628094.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    61. Graph theory analysis reveals how sickle cell disease impacts neural networks of patients with more severe disease. Neuroimage Clin. 2019; 21:101599. Case M, Shirinpour S, Vijayakumar V, Zhang H, Datta Y, Nelson S, Pergami P, Darbari DS, Gupta K, He B. PMID: 30477765; PMCID: PMC6411610.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    62. Iron Chelation with Transdermal Deferoxamine Accelerates Healing of Murine Sickle Cell Ulcers. Adv Wound Care (New Rochelle). 2018 Oct 01; 7(10):323-332. Rodrigues M, Bonham CA, Minniti CP, Gupta K, Longaker MT, Gurtner GC. PMID: 30374417; PMCID: PMC6203233.
      View in: PubMed   Mentions: 13     Fields:    
    63. Bartonella henselae Infection in Sickle Cell Disease Mice Is Associated with Hyperalgesia. Vector Borne Zoonotic Dis. 2019 Feb; 19(2):102-105. de Almeida AR, Vieira-Damiani G, da Silva MN, Lania BG, Soares TCB, Drummond MR, Lins KA, Ericson ME, Gupta K, Velho PENF. PMID: 30272535.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    64. Mouse Models of Pain in Sickle Cell Disease. Curr Protoc Neurosci. 2018 10; 85(1):e54. Sagi V, Song-Naba WL, Benson BA, Joshi SS, Gupta K. PMID: 30265442.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    65. Targeting pain at its source in sickle cell disease. Am J Physiol Regul Integr Comp Physiol. 2018 07 01; 315(1):R104-R112. Gupta K, Jahagirdar O, Gupta K. PMID: 29590553; PMCID: PMC6087885.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    66. Mast cell-neural interactions contribute to pain and itch. Immunol Rev. 2018 03; 282(1):168-187. Gupta K, Harvima IT. PMID: 29431216; PMCID: PMC5812374.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    67. Increased theta band EEG power in sickle cell disease patients. J Pain Res. 2018; 11:67-76. Case M, Shirinpour S, Zhang H, Datta YH, Nelson SC, Sadak KT, Gupta K, He B. PMID: 29343982; PMCID: PMC5749555.
      View in: PubMed   Mentions: 9  
    68. Targeting novel mechanisms of pain in sickle cell disease. Hematology Am Soc Hematol Educ Program. 2017 12 08; 2017(1):546-555. Tran H, Gupta M, Gupta K. PMID: 29222304; PMCID: PMC6142592.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    69. Targeting novel mechanisms of pain in sickle cell disease. Blood. 2017 11 30; 130(22):2377-2385. Tran H, Gupta M, Gupta K. PMID: 29187376; PMCID: PMC5709786.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    70. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chem Biol. 2017 Oct 19; 24(10):1259-1275.e6. Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, Bae YK, Wulfkuhle JD, Gallagher RI, Petricoin EF, Norris B, Flory CM, Schumacher RJ, O'Sullivan MG, Cao Q, Chu H, Lipscomb JD, Atkins WM, Gupta K, Kelekar A, Blair IA, Capdevila JH, Falck JR, Sligar SG, Poulos TL, Georg GI, Ambrose E, Potter DA. PMID: 28919040; PMCID: PMC5650512.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    71. Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis. Pain. 2017 Sep; 158(9):1711-1722. Uhelski ML, Gupta K, Simone DA. PMID: 28570479; PMCID: PMC5561456.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    72. A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade. Am J Hematol. 2017 Nov; 92(11):1119-1130. Solovey A, Somani A, Belcher JD, Milbauer L, Vincent L, Pawlinski R, Nath KA, Kelm RJ, Mackman N, O'Sullivan MG, Gupta K, Vercellotti GM, Hebbel RP. PMID: 28699284; PMCID: PMC5655742.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    73. Opioids and opioid receptors orchestrate wound repair. Transl Res. 2017 07; 185:13-23. Wang Y, Gupta M, Poonawala T, Farooqui M, Li Y, Peng F, Rao S, Ansonoff M, Pintar JE, Gupta K. PMID: 28554003; PMCID: PMC5515242.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    74. Transcriptomic analysis of gene signatures associated with sickle pain. Sci Data. 2017 05 16; 4:170051. Paul JA, Aich A, Abrahante JE, Wang Y, LaRue RS, Rathe SK, Kalland K, Mittal A, Jha R, Peng F, Largaespada DA, Bagchi A, Gupta K. PMID: 29292796; PMCID: PMC5749120.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    75. Functional MRI BOLD response in sickle mice with hyperalgesia. Blood Cells Mol Dis. 2017 06; 65:81-85. Wang Y, Wang X, Chen W, Gupta K, Zhu XH. PMID: 28579187; PMCID: PMC5521217.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    76. Acute and Late Bartonella henselae Murine Model Infection. Vector Borne Zoonotic Dis. 2017 03; 17(3):206-208. da Silva MN, Vieira-Damiani G, Ericson ME, Gupta K, de Almeida AR, Drummond MR, Soares TC, Lania BG, Gilioli R, Velho PE. PMID: 28165916; PMCID: PMC5333569.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    77. Characterization of functional brain activity and connectivity using EEG and fMRI in patients with sickle cell disease. Neuroimage Clin. 2017; 14:1-17. Case M, Zhang H, Mundahl J, Datta Y, Nelson S, Gupta K, He B. PMID: 28116239; PMCID: PMC5226854.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    78. Electroacupuncture in conscious free-moving mice reduces pain by ameliorating peripheral and central nociceptive mechanisms. Sci Rep. 2016 Sep 30; 6:34493. Wang Y, Lei J, Gupta M, Peng F, Lam S, Jha R, Raduenz E, Beitz AJ, Gupta K. PMID: 27687125; PMCID: PMC5043286.
      View in: PubMed   Mentions: 14     Fields:    
    79. Comparative Analysis of Pain Behaviours in Humanized Mouse Models of Sickle Cell Anemia. PLoS One. 2016; 11(8):e0160608. Lei J, Benson B, Tran H, Ofori-Acquah SF, Gupta K. PMID: 27494522; PMCID: PMC4975462.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    80. Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease. Haematologica. 2016 10; 101(10):e397-e400. Nwankwo JO, Lei J, Xu J, Rivera A, Gupta K, Chishti AH. PMID: 27418647; PMCID: PMC5046659.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    81. Bartonella henselae transmission by blood transfusion in mice. Transfusion. 2016 06; 56(6 Pt 2):1556-9. Silva MN, Vieira-Damiani G, Ericson ME, Gupta K, Gilioli R, de Almeida AR, Drummond MR, Lania BG, de Almeida Lins K, Soares TC, Velho PE. PMID: 26968530; PMCID: PMC4905798.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    82. Bartonella henselae initial infection of mature human erythrocytes observed in real time using bacterial endogenous fluorescence. J Trop Dis Public Health. 2016 Apr; 4(2). Vieira-Damiani G, Ericson ME, da Silva MN, Gupta K, Soares TB, de Almeida AR, Pelegati VB, Baratti MO, Cesar CL, Cintra ML, Velho PENF. PMID: 29034332; PMCID: PMC5639914.
      View in: PubMed   Mentions: 5  
    83. Could Perioperative Opioid Use Increase the Risk of Cancer Progression and Metastases? Int Anesthesiol Clin. 2016; 54(4):e1-e16. Aich A, Gupta P, Gupta K. PMID: 27602710; PMCID: PMC5061339.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    84. Cannabinoid receptor-specific mechanisms to alleviate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation. Haematologica. 2016 05; 101(5):566-77. Vincent L, Vang D, Nguyen J, Benson B, Lei J, Gupta K. PMID: 26703965; PMCID: PMC5004356.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    85. Quantification of pain in sickle mice using facial expressions and body measurements. Blood Cells Mol Dis. 2016 Mar; 57:58-66. Mittal A, Gupta M, Lamarre Y, Jahagirdar B, Gupta K. PMID: 26852657; PMCID: PMC4746724.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    86. Mast Cell-Mediated Mechanisms of Nociception. Int J Mol Sci. 2015 Dec 04; 16(12):29069-92. Aich A, Afrin LB, Gupta K. PMID: 26690128; PMCID: PMC4691098.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    87. Spinal glial activation and oxidative stress are alleviated by treatment with curcumin or coenzyme Q in sickle mice. Haematologica. 2016 Feb; 101(2):e44-7. Valverde Y, Benson B, Gupta M, Gupta K. PMID: 26546503; PMCID: PMC4938337.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    88. Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice. Haematologica. 2015 Dec; 100(12):1517-25. Vang D, Paul JA, Nguyen J, Tran H, Vincent L, Yasuda D, Zaveri NT, Gupta K. PMID: 26294734; PMCID: PMC4666327.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    89. Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease. Pain. 2015 Apr; 156(4):722-730. Cataldo G, Rajput S, Gupta K, Simone DA. PMID: 25630029; PMCID: PMC4366346.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    90. Topical fentanyl stimulates healing of ischemic wounds in diabetic rats. J Diabetes. 2015 Jul; 7(4):573-583. Gupta M, Poonawala T, Farooqui M, Ericson ME, Gupta K. PMID: 25266258; PMCID: PMC4844062.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    91. Morphine for the treatment of pain in sickle cell disease. ScientificWorldJournal. 2015; 2015:540154. Gupta M, Msambichaka L, Ballas SK, Gupta K. PMID: 25654130; PMCID: PMC4306369.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    92. Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene. Cell Rep. 2014 Sep 11; 8(5):1484-96. Dandapat A, Bosnakovski D, Hartweck LM, Arpke RW, Baltgalvis KA, Vang D, Baik J, Darabi R, Perlingeiro RC, Hamra FK, Gupta K, Lowe DA, Kyba M. PMID: 25176645; PMCID: PMC4188423.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    93. Opioid requirement, opioid receptor expression, and clinical outcomes in patients with advanced prostate cancer. Cancer. 2013 Dec 01; 119(23):4103-10. Zylla D, Gourley BL, Vang D, Jackson S, Boatman S, Lindgren B, Kuskowski MA, Le C, Gupta K, Gupta P. PMID: 24104703; PMCID: PMC3833881.
      View in: PubMed   Mentions: 97     Fields:    Translation:Humans
    94. Mast cell activation contributes to sickle cell pathobiology and pain in mice. Blood. 2013 Sep 12; 122(11):1853-62. Vincent L, Vang D, Nguyen J, Gupta M, Luk K, Ericson ME, Simone DA, Gupta K. PMID: 23775718; PMCID: PMC3772495.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    95. Tumor angiogenesis 2012. J Oncol. 2012; 2012:857383. Dudek AZ, Gupta K, Ramakrishnan S, Mukhopadhyay D. PMID: 22919384; PMCID: PMC3419421.
      View in: PubMed   Mentions: 1  
    96. Carbon-fiber microelectrode amperometry reveals sickle-cell-induced inflammation and chronic morphine effects on single mast cells. ACS Chem Biol. 2012 Mar 16; 7(3):543-51. Manning BM, Hebbel RP, Gupta K, Haynes CL. PMID: 22217155; PMCID: PMC3306545.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    97. Influence of morphine on pericyte-endothelial interaction: implications for antiangiogenic therapy. J Oncol. 2012; 2012:458385. Luk K, Boatman S, Johnson KN, Dudek OA, Ristau N, Vang D, Nguyen J, Gupta K. PMID: 22315595; PMCID: PMC3270445.
      View in: PubMed   Mentions: 22  
    98. Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness. Br J Haematol. 2012 Feb; 156(4):535-44. Cain DM, Vang D, Simone DA, Hebbel RP, Gupta K. PMID: 22171826; PMCID: PMC3779783.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimals
    99. Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer. Anesth Analg. 2011 Dec; 113(6):1353-64. Fujioka N, Nguyen J, Chen C, Li Y, Pasrija T, Niehans G, Johnson KN, Gupta V, Kratzke RA, Gupta K. PMID: 22003224; PMCID: PMC3725599.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    100. CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). J Biol Chem. 2011 May 20; 286(20):17543-59. Mitra R, Guo Z, Milani M, Mesaros C, Rodriguez M, Nguyen J, Luo X, Clarke D, Lamba J, Schuetz E, Donner DB, Puli N, Falck JR, Capdevila J, Gupta K, Blair IA, Potter DA. PMID: 21402692; PMCID: PMC3093829.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    101. Tumor angiogenesis. J Oncol. 2010; 2010. Dudek A, Gupta K, Ramakrishnan S, Mukhopadhyay D. PMID: 20886025; PMCID: PMC2945670.
      View in: PubMed   Mentions: 3  
    102. Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids. Blood. 2010 Jul 22; 116(3):456-65. Kohli DR, Li Y, Khasabov SG, Gupta P, Kehl LJ, Ericson ME, Nguyen J, Gupta V, Hebbel RP, Simone DA, Gupta K. PMID: 20304807; PMCID: PMC2913454.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    103. Mactinin, a fragment of cytoskeletal alpha-actinin, is a novel inducer of heat shock protein (Hsp)-90 mediated monocyte activation. BMC Cell Biol. 2009 Aug 28; 10:60. Luikart SD, Panoskaltsis-Mortari A, Hinkel T, Perri RT, Gupta K, Oegema TR, Gupta P. PMID: 19715605; PMCID: PMC2743639.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    104. Antitumor activity of a PPARdelta antagonist. Cancer Biol Ther. 2009 Jul; 8(13):1262-4. Elikkottil J, Kohli DR, Gupta K. PMID: 19502779.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    105. Morphine induces mesangial cell proliferation and glomerulopathy via kappa-opioid receptors. Am J Physiol Renal Physiol. 2008 Jun; 294(6):F1388-97. Weber ML, Farooqui M, Nguyen J, Ansonoff M, Pintar JE, Hebbel RP, Gupta K. PMID: 18385270.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    106. Opioids induce renal abnormalities in tumor-bearing mice. Nephron Exp Nephrol. 2007; 105(3):e80-9. Arerangaiah R, Chalasani N, Udager AM, Weber ML, Manivel JC, Griffin RJ, Song CW, Gupta K. PMID: 17220637.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    107. Morphine stimulates vascular endothelial growth factor-like signaling in mouse retinal endothelial cells. Curr Neurovasc Res. 2006 Aug; 3(3):171-80. Chen C, Farooqui M, Gupta K. PMID: 16918381.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    108. Renal effects of opioid exposure: considerations for therapeutic use. J Opioid Manag. 2006 Jul-Aug; 2(4):236-40. Gupta K, Weber ML. PMID: 17319485.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    109. Naloxone acts as an antagonist of estrogen receptor activity in MCF-7 cells. Mol Cancer Ther. 2006 Mar; 5(3):611-20. Farooqui M, Geng ZH, Stephenson EJ, Zaveri N, Yee D, Gupta K. PMID: 16546975.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    110. Opioids heal ischemic wounds in the rat. Wound Repair Regen. 2005 Mar-Apr; 13(2):165-74. Poonawala T, Levay-Young BK, Hebbel RP, Gupta K. PMID: 15828941.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    111. Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes. Blood. 2003 Oct 01; 102(7):2678-83. Shet AS, Aras O, Gupta K, Hass MJ, Rausch DJ, Saba N, Koopmeiners L, Key NS, Hebbel RP. PMID: 12805058.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansCells
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