Kalpna Gupta

Title(s)Professor In Residence, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system
    NIH R01CA263806Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    Summer Mentoring and Research Training (SMART)
    NIH T35DK128788Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Targeting mechanisms contributing to vascular dysfunction and pain in sickle cell disease
    NIH R01HL147562Apr 4, 2019 - Mar 31, 2023
    Role: Principal Investigator
    Cannabinoid-based therapy and approaches to quantify pain in sickle cell disease
    NIH U01HL117664Aug 15, 2013 - May 31, 2019
    Role: Principal Investigator
    Characteristics and mechanisms of pain in sickle cell disease
    NIH R01HL103733Sep 5, 2010 - Aug 31, 2016
    Role: Principal Investigator
    Opioid and Breast Cancer Growth and Metastasis
    NIH R01CA109582Apr 1, 2005 - Feb 29, 2012
    Role: Principal Investigator
    Opioid Activity in Endothelium in Sickle Cell Disease
    NIH R01HL068802Apr 1, 2002 - May 31, 2014
    Role: Principal Investigator
    Cannabinoid Modulation of Hyperalgesia
    NIH R01HL135895Feb 3, 2000 - Jun 30, 2021
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Red Blood Cells as Therapeutic Target to Treat Sickle Cell Disease. Antioxid Redox Signal. 2024 Jan 23. Bhatt S, Argueta DA, Gupta K, Kundu S. PMID: 37975291.
      View in: PubMed   Mentions:    Fields:    
    2. Colchicine reduces inflammation in a humanized transgenic murine model of sickle cell disease. Haematologica. 2024 Jan 01; 109(1):308-311. Fouda RT, Cherukury HM, Kiven SB, Garcia NR, Argueta DA, Velasco GJ, Gupta K, Roberts JD. PMID: 37534545; PMCID: PMC10772532.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation. Blood. 2023 11 30; 142(22):1918-1927. Ivy ZK, Belcher JD, Khasabova IA, Chen C, Juliette JP, Abdulla F, Ruan C, Allen K, Nguyen J, Rogness VM, Beckman JD, Khasabov SG, Gupta K, Taylor RP, Simone DA, Vercellotti GM. PMID: 37774369; PMCID: PMC10731576.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Crosstalk of Mast Cells and Natural Killer Cells with Neurons in Chemotherapy-Induced Peripheral Neuropathy. Int J Mol Sci. 2023 Aug 08; 24(16). Yun HD, Goel Y, Gupta K. PMID: 37628724; PMCID: PMC10454469.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Descending Facilitation of Nociceptive Transmission From the Rostral Ventromedial Medulla Contributes to Hyperalgesia in Mice with Sickle Cell Disease. Neuroscience. 2023 08 21; 526:1-12. Rogness VM, Juliette J, Khasabova IA, Gupta K, Khasabov SG, Simone DA. PMID: 37330194; PMCID: PMC10528639.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Assessment of gait in mice using simplified analysis tools. Res Sq. 2023 May 05. Fouda R, Argueta D, O'Daniel K, Peterson K, Sorto T, Gupta K. PMID: 37205356; PMCID: PMC10187402.
      View in: PubMed   Mentions:
    7. Inhibition of DAGLβ as a therapeutic target for pain in sickle cell disease. Haematologica. 2023 03 01; 108(3):859-869. Khasabova IA, Gable J, Johns M, Khasabov SG, Kalyuzhny AE, Golovko MY, Golovko SA, Kiven S, Gupta K, Seybold VS, Simone DA. PMID: 35615929; PMCID: PMC9973472.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    8. Cannabidiol attenuates hyperalgesia in a mouse model of sickle cell disease. Blood. 2023 01 12; 141(2):203-208. Cherukury HM, Argueta DA, Garcia N, Fouda R, Kiven S, Lei J, Sagi V, Velasco GJ, Avalos B, DiPatrizio NV, Gupta K. PMID: 36122382; PMCID: PMC9936305.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    9. A model of painful vaso-occlusive crisis in mice with sickle cell disease. Blood. 2022 10 20; 140(16):1826-1830. Khasabova II, Juliette J, Rogness VM, Khasabov SG, Golovko MY, Golovko SA, Kiven S, Gupta K, Belcher JD, Vercellotti GM, Seybold VS, Simone DA. PMID: 35960856; PMCID: PMC9837430.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    10. Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease. Front Oncol. 2022; 12:969429. Sargur Madabushi S, Fouda R, Ghimire H, Abdelhamid AMH, Lim JE, Vishwasrao P, Kiven S, Brooks J, Zuro D, Rosenthal J, Guha C, Gupta K, Hui SK. PMID: 36147914; PMCID: PMC9485604.
      View in: PubMed   Mentions: 1  
    11. Pain in Hemophilia: Unexplored Role of Oxidative Stress. Antioxidants (Basel). 2022 Jun 03; 11(6). Fouda R, Argueta DA, Gupta K. PMID: 35740010; PMCID: PMC9220316.
      View in: PubMed   Mentions: 1  
    12. Endoplasmic Reticulum Stress in Chemotherapy-Induced Peripheral Neuropathy: Emerging Role of Phytochemicals. Antioxidants (Basel). 2022 Jan 28; 11(2). Goel Y, Fouda R, Gupta K. PMID: 35204148; PMCID: PMC8868275.
      View in: PubMed   Mentions: 3  
    13. Pain in sickle cell disease: current and potential translational therapies. Transl Res. 2021 08; 234:141-158. Sagi V, Mittal A, Tran H, Gupta K. PMID: 33711512; PMCID: PMC8217144.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    14. Cognitive complications of cancer and cancer-related treatments - Novel paradigms. Neurosci Lett. 2021 04 01; 749:135720. Lomeli N, Lepe J, Gupta K, Bota DA. PMID: 33582187; PMCID: PMC8423125.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Diet and companionship modulate pain via a serotonergic mechanism. Sci Rep. 2021 02 01; 11(1):2330. Tran H, Sagi V, Jarrett S, Palzer EF, Badgaiyan RD, Gupta K. PMID: 33526805; PMCID: PMC7851147.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. β-endorphin at the intersection of pain and cancer progression: Preclinical evidence. Neurosci Lett. 2021 01 23; 744:135601. Argueta DA, Aich A, Lei J, Kiven S, Nguyen A, Wang Y, Gu J, Zhao W, Gupta K. PMID: 33387660; PMCID: PMC7837276.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. Considerations for Cannabis Use to Treat Pain in Sickle Cell Disease. J Clin Med. 2020 Dec 01; 9(12). Argueta DA, Aich A, Muqolli F, Cherukury H, Sagi V, DiPatrizio NV, Gupta K. PMID: 33271850; PMCID: PMC7761429.
      View in: PubMed   Mentions: 3  
    18. Spatiotemporal Alterations in Gait in Humanized Transgenic Sickle Mice. Front Immunol. 2020; 11:561947. Kiven S, Wang Y, Aich A, Argueta DA, Lei J, Sagi V, Tennakoon M, Bedros SJ, Lambrecht N, Gupta K. PMID: 33178189; PMCID: PMC7593487.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. Self-Assembled 3D Nanosplit Rings for Plasmon-Enhanced Optofluidic Sensing. Nano Lett. 2020 09 09; 20(9):6697-6705. Dai C, Lin Z, Agarwal K, Mikhael C, Aich A, Gupta K, Cho JH. PMID: 32808792.
      View in: PubMed   Mentions: 3     Fields:    
    20. Heme Causes Pain in Sickle Mice via Toll-Like Receptor 4-Mediated Reactive Oxygen Species- and Endoplasmic Reticulum Stress-Induced Glial Activation. Antioxid Redox Signal. 2021 02 01; 34(4):279-293. Lei J, Paul J, Wang Y, Gupta M, Vang D, Thompson S, Jha R, Nguyen J, Valverde Y, Lamarre Y, Jones MK, Gupta K. PMID: 32729340; PMCID: PMC7821434.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    21. Effect of Inhaled Cannabis for Pain in Adults With Sickle Cell Disease: A Randomized Clinical Trial. JAMA Netw Open. 2020 07 01; 3(7):e2010874. Abrams DI, Couey P, Dixit N, Sagi V, Hagar W, Vichinsky E, Kelly ME, Connett JE, Gupta K. PMID: 32678452; PMCID: PMC7368173.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    22. Integrative approaches to treating pain in sickle cell disease: Pre-clinical and clinical evidence. Complement Ther Med. 2020 Jun; 51:102394. Sagi V, Argueta DA, Kiven S, Gupta K. PMID: 32507420; PMCID: PMC7306403.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    23. A Balanced Approach for Cannabidiol Use in Chronic Pain. Front Pharmacol. 2020; 11:561. Argueta DA, Ventura CM, Kiven S, Sagi V, Gupta K. PMID: 32425793; PMCID: PMC7204604.
      View in: PubMed   Mentions: 18  
    24. Substance P modulates electroacupuncture analgesia in humanized mice with sickle cell disease. J Pain Res. 2019; 12:2419-2426. Wang Y, Lei J, Jha RK, Kiven S, Gupta K. PMID: 31447579; PMCID: PMC6682765.
      View in: PubMed   Mentions: 6  
    25. Pain and sickle cell disease. Curr Opin Hematol. 2019 05; 26(3):131-138. Aich A, Jones MK, Gupta K. PMID: 30893088.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    26. Effect of chronic opioid therapy on pain and survival in a humanized mouse model of sickle cell disease. Blood Adv. 2019 03 26; 3(6):869-873. Tran H, Sagi V, Leonce Song-Naba W, Wang Y, Mittal A, Lamarre Y, Zhang L, Gupta K. PMID: 30885998; PMCID: PMC6436015.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    27. Mast Cell Neural Interactions in Health and Disease. Front Cell Neurosci. 2019; 13:110. Mittal A, Sagi V, Gupta M, Gupta K. PMID: 30949032; PMCID: PMC6435484.
      View in: PubMed   Mentions: 24  
    28. Sensitization of nociceptors by prostaglandin E2-glycerol contributes to hyperalgesia in mice with sickle cell disease. Blood. 2019 05 02; 133(18):1989-1998. Khasabova IA, Uhelski M, Khasabov SG, Gupta K, Seybold VS, Simone DA. PMID: 30796025; PMCID: PMC6497514.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    29. Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium. Front Cell Neurosci. 2019; 13:56. Tran H, Mittal A, Sagi V, Luk K, Nguyen A, Gupta M, Nguyen J, Lamarre Y, Lei J, Guedes A, Gupta K. PMID: 30837844; PMCID: PMC6389721.
      View in: PubMed   Mentions: 18  
    30. Diet and gender influence survival of transgenic Berkley sickle cell mice. Haematologica. 2019 08; 104(8):e331-e334. Jahagirdar OB, Mittal AM, Song-Naba WL, Jha R, Kiven SB, Thompson ST, Connett JE, Gupta K. PMID: 30765475; PMCID: PMC6669136.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    31. Immune cell neural interactions and their contributions to sickle cell disease. Neurosci Lett. 2019 04 23; 699:167-171. Sagi V, Mittal A, Gupta M, Gupta K. PMID: 30738871.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    32. Bartonella henselae Infection in Sickle Cell Disease Mice Is Associated with Hyperalgesia. Vector Borne Zoonotic Dis. 2019 Feb; 19(2):102-105. de Almeida AR, Vieira-Damiani G, da Silva MN, Lania BG, Soares TCB, Drummond MR, Lins KA, Ericson ME, Gupta K, Velho PENF. PMID: 30272535.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    33. Mouse Models of Pain in Sickle Cell Disease. Curr Protoc Neurosci. 2018 10; 85(1):e54. Sagi V, Song-Naba WL, Benson BA, Joshi SS, Gupta K. PMID: 30265442.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    34. Targeting pain at its source in sickle cell disease. Am J Physiol Regul Integr Comp Physiol. 2018 07 01; 315(1):R104-R112. Gupta K, Jahagirdar O, Gupta K. PMID: 29590553; PMCID: PMC6087885.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    35. Targeting novel mechanisms of pain in sickle cell disease. Blood. 2017 11 30; 130(22):2377-2385. Tran H, Gupta M, Gupta K. PMID: 29187376; PMCID: PMC5709786.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    36. Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis. Pain. 2017 Sep; 158(9):1711-1722. Uhelski ML, Gupta K, Simone DA. PMID: 28570479; PMCID: PMC5561456.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    37. A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade. Am J Hematol. 2017 Nov; 92(11):1119-1130. Solovey A, Somani A, Belcher JD, Milbauer L, Vincent L, Pawlinski R, Nath KA, Kelm RJ, Mackman N, O'Sullivan MG, Gupta K, Vercellotti GM, Hebbel RP. PMID: 28699284; PMCID: PMC5655742.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    38. Transcriptomic analysis of gene signatures associated with sickle pain. Sci Data. 2017 05 16; 4:170051. Paul JA, Aich A, Abrahante JE, Wang Y, LaRue RS, Rathe SK, Kalland K, Mittal A, Jha R, Peng F, Largaespada DA, Bagchi A, Gupta K. PMID: 29292796; PMCID: PMC5749120.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    39. Functional MRI BOLD response in sickle mice with hyperalgesia. Blood Cells Mol Dis. 2017 06; 65:81-85. Wang Y, Wang X, Chen W, Gupta K, Zhu XH. PMID: 28579187; PMCID: PMC5521217.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    40. Electroacupuncture in conscious free-moving mice reduces pain by ameliorating peripheral and central nociceptive mechanisms. Sci Rep. 2016 Sep 30; 6:34493. Wang Y, Lei J, Gupta M, Peng F, Lam S, Jha R, Raduenz E, Beitz AJ, Gupta K. PMID: 27687125; PMCID: PMC5043286.
      View in: PubMed   Mentions: 13     Fields:    
    41. Comparative Analysis of Pain Behaviours in Humanized Mouse Models of Sickle Cell Anemia. PLoS One. 2016; 11(8):e0160608. Lei J, Benson B, Tran H, Ofori-Acquah SF, Gupta K. PMID: 27494522; PMCID: PMC4975462.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    42. Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease. Haematologica. 2016 10; 101(10):e397-e400. Nwankwo JO, Lei J, Xu J, Rivera A, Gupta K, Chishti AH. PMID: 27418647; PMCID: PMC5046659.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    43. Could Perioperative Opioid Use Increase the Risk of Cancer Progression and Metastases? Int Anesthesiol Clin. 2016; 54(4):e1-e16. Aich A, Gupta P, Gupta K. PMID: 27602710; PMCID: PMC5061339.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    44. Cannabinoid receptor-specific mechanisms to alleviate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation. Haematologica. 2016 05; 101(5):566-77. Vincent L, Vang D, Nguyen J, Benson B, Lei J, Gupta K. PMID: 26703965; PMCID: PMC5004356.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    45. Quantification of pain in sickle mice using facial expressions and body measurements. Blood Cells Mol Dis. 2016 Mar; 57:58-66. Mittal A, Gupta M, Lamarre Y, Jahagirdar B, Gupta K. PMID: 26852657; PMCID: PMC4746724.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    46. Mast Cell-Mediated Mechanisms of Nociception. Int J Mol Sci. 2015 Dec 04; 16(12):29069-92. Aich A, Afrin LB, Gupta K. PMID: 26690128; PMCID: PMC4691098.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    47. Spinal glial activation and oxidative stress are alleviated by treatment with curcumin or coenzyme Q in sickle mice. Haematologica. 2016 Feb; 101(2):e44-7. Valverde Y, Benson B, Gupta M, Gupta K. PMID: 26546503; PMCID: PMC4938337.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    48. Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice. Haematologica. 2015 Dec; 100(12):1517-25. Vang D, Paul JA, Nguyen J, Tran H, Vincent L, Yasuda D, Zaveri NT, Gupta K. PMID: 26294734; PMCID: PMC4666327.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    49. Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease. Pain. 2015 Apr; 156(4):722-730. Cataldo G, Rajput S, Gupta K, Simone DA. PMID: 25630029; PMCID: PMC4366346.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    50. Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene. Cell Rep. 2014 Sep 11; 8(5):1484-96. Dandapat A, Bosnakovski D, Hartweck LM, Arpke RW, Baltgalvis KA, Vang D, Baik J, Darabi R, Perlingeiro RC, Hamra FK, Gupta K, Lowe DA, Kyba M. PMID: 25176645; PMCID: PMC4188423.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    51. Mast cell activation contributes to sickle cell pathobiology and pain in mice. Blood. 2013 Sep 12; 122(11):1853-62. Vincent L, Vang D, Nguyen J, Gupta M, Luk K, Ericson ME, Simone DA, Gupta K. PMID: 23775718; PMCID: PMC3772495.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    52. Carbon-fiber microelectrode amperometry reveals sickle-cell-induced inflammation and chronic morphine effects on single mast cells. ACS Chem Biol. 2012 Mar 16; 7(3):543-51. Manning BM, Hebbel RP, Gupta K, Haynes CL. PMID: 22217155; PMCID: PMC3306545.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    53. Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness. Br J Haematol. 2012 Feb; 156(4):535-44. Cain DM, Vang D, Simone DA, Hebbel RP, Gupta K. PMID: 22171826; PMCID: PMC3779783.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    54. Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids. Blood. 2010 Jul 22; 116(3):456-65. Kohli DR, Li Y, Khasabov SG, Gupta P, Kehl LJ, Ericson ME, Nguyen J, Gupta V, Hebbel RP, Simone DA, Gupta K. PMID: 20304807; PMCID: PMC2913454.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
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