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Kalpna Gupta

Title(s)VIS PROF, Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Summer Mentoring and Research Training (SMART)
    NIH T35DK128788Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Targeting mechanisms contributing to vascular dysfunction and pain in sickle cell disease
    NIH R01HL147562Apr 4, 2019 - Mar 31, 2023
    Role: Principal Investigator
    Cannabinoid-based therapy and approaches to quantify pain in sickle cell disease
    NIH U01HL117664Aug 15, 2013 - May 31, 2019
    Role: Principal Investigator
    Characteristics and mechanisms of pain in sickle cell disease
    NIH R01HL103733Sep 5, 2010 - Aug 31, 2016
    Role: Principal Investigator
    Opioid and Breast Cancer Growth and Metastasis
    NIH R01CA109582Apr 1, 2005 - Mar 31, 2010
    Role: Principal Investigator
    Opioid Activity in Endothelium in Sickle Cell Disease
    NIH R01HL068802Apr 1, 2002 - May 31, 2014
    Role: Principal Investigator
    Cannabinoid Modulation of Hyperalgesia
    NIH R01HL135895Feb 3, 2000 - Jun 30, 2021
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pain in sickle cell disease: current and potential translational therapies. Transl Res. 2021 Mar 09. PMID: 33711512.
      View in: PubMed   Mentions:    Fields:    
    2. Cognitive complications of cancer and cancer-related treatments - Novel paradigms. Neurosci Lett. 2021 Feb 11; 749:135720. Lomeli N, Lepe J, Gupta K, Bota DA. PMID: 33582187.
      View in: PubMed   Mentions:    Fields:    
    3. Diet and companionship modulate pain via a serotonergic mechanism. Sci Rep. 2021 Feb 01; 11(1):2330. Tran H, Sagi V, Jarrett S, Palzer EF, Badgaiyan RD, Gupta K. PMID: 33526805.
      View in: PubMed   Mentions:    Fields:    
    4. ß-endorphin at the intersection of pain and cancer progression: Preclinical evidence. Neurosci Lett. 2020 Dec 30; 744:135601. Argueta DA, Aich A, Lei J, Kiven S, Nguyen A, Wang Y, Gu J, Zhao W, Gupta K. PMID: 33387660.
      View in: PubMed   Mentions:    Fields:    
    5. Considerations for Cannabis Use to Treat Pain in Sickle Cell Disease. J Clin Med. 2020 Dec 01; 9(12). Argueta DA, Aich A, Muqolli F, Cherukury H, Sagi V, DiPatrizio NV, Gupta K. PMID: 33271850.
      View in: PubMed   Mentions:
    6. Spatiotemporal Alterations in Gait in Humanized Transgenic Sickle Mice. Front Immunol. 2020; 11:561947. Kiven S, Wang Y, Aich A, Argueta DA, Lei J, Sagi V, Tennakoon M, Bedros SJ, Lambrecht N, Gupta K. PMID: 33178189.
      View in: PubMed   Mentions: 1     Fields:    
    7. Self-Assembled 3D Nanosplit Rings for Plasmon-Enhanced Optofluidic Sensing. Nano Lett. 2020 09 09; 20(9):6697-6705. Dai C, Lin Z, Agarwal K, Mikhael C, Aich A, Gupta K, Cho JH. PMID: 32808792.
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    8. Heme Causes Pain in Sickle Mice via Toll-Like Receptor 4-Mediated Reactive Oxygen Species- and Endoplasmic Reticulum Stress-Induced Glial Activation. Antioxid Redox Signal. 2021 Feb 01; 34(4):279-293. Lei J, Paul J, Wang Y, Gupta M, Vang D, Thompson S, Jha R, Nguyen J, Valverde Y, Lamarre Y, Jones MK, Gupta K. PMID: 32729340.
      View in: PubMed   Mentions:
    9. Effect of Inhaled Cannabis for Pain in Adults With Sickle Cell Disease: A Randomized Clinical Trial. JAMA Netw Open. 2020 07 01; 3(7):e2010874. Abrams DI, Couey P, Dixit N, Sagi V, Hagar W, Vichinsky E, Kelly ME, Connett JE, Gupta K. PMID: 32678452.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Integrative approaches to treating pain in sickle cell disease: Pre-clinical and clinical evidence. Complement Ther Med. 2020 Jun; 51:102394. Sagi V, Argueta DA, Kiven S, Gupta K. PMID: 32507420.
      View in: PubMed   Mentions:
    11. A Balanced Approach for Cannabidiol Use in Chronic Pain. Front Pharmacol. 2020; 11:561. Argueta DA, Ventura CM, Kiven S, Sagi V, Gupta K. PMID: 32425793.
      View in: PubMed   Mentions:
    12. Substance P modulates electroacupuncture analgesia in humanized mice with sickle cell disease. J Pain Res. 2019; 12:2419-2426. Wang Y, Lei J, Jha RK, Kiven S, Gupta K. PMID: 31447579.
      View in: PubMed   Mentions:
    13. Pain and sickle cell disease. Curr Opin Hematol. 2019 05; 26(3):131-138. Aich A, Jones MK, Gupta K. PMID: 30893088.
      View in: PubMed   Mentions:
    14. Effect of chronic opioid therapy on pain and survival in a humanized mouse model of sickle cell disease. Blood Adv. 2019 03 26; 3(6):869-873. Tran H, Sagi V, Leonce Song-Naba W, Wang Y, Mittal A, Lamarre Y, Zhang L, Gupta K. PMID: 30885998.
      View in: PubMed   Mentions:
    15. Mast Cell Neural Interactions in Health and Disease. Front Cell Neurosci. 2019; 13:110. Mittal A, Sagi V, Gupta M, Gupta K. PMID: 30949032.
      View in: PubMed   Mentions:
    16. Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium. Front Cell Neurosci. 2019; 13:56. Tran H, Mittal A, Sagi V, Luk K, Nguyen A, Gupta M, Nguyen J, Lamarre Y, Lei J, Guedes A, Gupta K. PMID: 30837844.
      View in: PubMed   Mentions:
    17. Diet and gender influence survival of transgenic Berkley sickle cell mice. Haematologica. 2019 08; 104(8):e331-e334. Jahagirdar OB, Mittal AM, Song-Naba WL, Jha R, Kiven SB, Thompson ST, Connett JE, Gupta K. PMID: 30765475.
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    18. Immune cell neural interactions and their contributions to sickle cell disease. Neurosci Lett. 2019 04 23; 699:167-171. Sagi V, Mittal A, Gupta M, Gupta K. PMID: 30738871.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Mouse Models of Pain in Sickle Cell Disease. Curr Protoc Neurosci. 2018 10; 85(1):e54. Sagi V, Song-Naba WL, Benson BA, Joshi SS, Gupta K. PMID: 30265442.
      View in: PubMed   Mentions:
    20. Transcriptomic analysis of gene signatures associated with sickle pain. Sci Data. 2017 05 16; 4:170051. Paul JA, Aich A, Abrahante JE, Wang Y, LaRue RS, Rathe SK, Kalland K, Mittal A, Jha R, Peng F, Largaespada DA, Bagchi A, Gupta K. PMID: 29292796.
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    21. Electroacupuncture in conscious free-moving mice reduces pain by ameliorating peripheral and central nociceptive mechanisms. Sci Rep. 2016 Sep 30; 6:34493. Wang Y, Lei J, Gupta M, Peng F, Lam S, Jha R, Raduenz E, Beitz AJ, Gupta K. PMID: 27687125.
      View in: PubMed   Mentions:
    22. Comparative Analysis of Pain Behaviours in Humanized Mouse Models of Sickle Cell Anemia. PLoS One. 2016; 11(8):e0160608. Lei J, Benson B, Tran H, Ofori-Acquah SF, Gupta K. PMID: 27494522.
      View in: PubMed   Mentions:
    23. Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease. Haematologica. 2016 10; 101(10):e397-e400. Nwankwo JO, Lei J, Xu J, Rivera A, Gupta K, Chishti AH. PMID: 27418647.
      View in: PubMed   Mentions:
    24. Could Perioperative Opioid Use Increase the Risk of Cancer Progression and Metastases? Int Anesthesiol Clin. 2016; 54(4):e1-e16. Aich A, Gupta P, Gupta K. PMID: 27602710.
      View in: PubMed   Mentions:
    25. Cannabinoid receptor-specific mechanisms to alleviate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation. Haematologica. 2016 05; 101(5):566-77. Vincent L, Vang D, Nguyen J, Benson B, Lei J, Gupta K. PMID: 26703965.
      View in: PubMed   Mentions:
    26. Mast Cell-Mediated Mechanisms of Nociception. Int J Mol Sci. 2015 Dec 04; 16(12):29069-92. Aich A, Afrin LB, Gupta K. PMID: 26690128.
      View in: PubMed   Mentions:
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