Kalpna Gupta

Title(s)VIS PROF, Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system
    NIH R01CA263806Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    Summer Mentoring and Research Training (SMART)
    NIH T35DK128788Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Targeting mechanisms contributing to vascular dysfunction and pain in sickle cell disease
    NIH R01HL147562Apr 4, 2019 - Mar 31, 2023
    Role: Principal Investigator
    Cannabinoid-based therapy and approaches to quantify pain in sickle cell disease
    NIH U01HL117664Aug 15, 2013 - May 31, 2019
    Role: Principal Investigator
    Characteristics and mechanisms of pain in sickle cell disease
    NIH R01HL103733Sep 5, 2010 - Aug 31, 2016
    Role: Principal Investigator
    Opioid and Breast Cancer Growth and Metastasis
    NIH R01CA109582Apr 1, 2005 - Feb 29, 2012
    Role: Principal Investigator
    Opioid Activity in Endothelium in Sickle Cell Disease
    NIH R01HL068802Apr 1, 2002 - May 31, 2014
    Role: Principal Investigator
    Cannabinoid Modulation of Hyperalgesia
    NIH R01HL135895Feb 3, 2000 - Jun 30, 2021
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pain in sickle cell disease: current and potential translational therapies. Transl Res. 2021 Mar 09. Sagi V, Mittal A, Tran H, Gupta K. PMID: 33711512.
      View in: PubMed   Mentions:    Fields:    
    2. Cognitive complications of cancer and cancer-related treatments - Novel paradigms. Neurosci Lett. 2021 04 01; 749:135720. Lomeli N, Lepe J, Gupta K, Bota DA. PMID: 33582187.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Diet and companionship modulate pain via a serotonergic mechanism. Sci Rep. 2021 Feb 01; 11(1):2330. Tran H, Sagi V, Jarrett S, Palzer EF, Badgaiyan RD, Gupta K. PMID: 33526805.
      View in: PubMed   Mentions: 1     Fields:    
    4. ß-endorphin at the intersection of pain and cancer progression: Preclinical evidence. Neurosci Lett. 2021 01 23; 744:135601. Argueta DA, Aich A, Lei J, Kiven S, Nguyen A, Wang Y, Gu J, Zhao W, Gupta K. PMID: 33387660.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Considerations for Cannabis Use to Treat Pain in Sickle Cell Disease. J Clin Med. 2020 Dec 01; 9(12). Argueta DA, Aich A, Muqolli F, Cherukury H, Sagi V, DiPatrizio NV, Gupta K. PMID: 33271850.
      View in: PubMed   Mentions:
    6. Spatiotemporal Alterations in Gait in Humanized Transgenic Sickle Mice. Front Immunol. 2020; 11:561947. Kiven S, Wang Y, Aich A, Argueta DA, Lei J, Sagi V, Tennakoon M, Bedros SJ, Lambrecht N, Gupta K. PMID: 33178189.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Self-Assembled 3D Nanosplit Rings for Plasmon-Enhanced Optofluidic Sensing. Nano Lett. 2020 09 09; 20(9):6697-6705. Dai C, Lin Z, Agarwal K, Mikhael C, Aich A, Gupta K, Cho JH. PMID: 32808792.
      View in: PubMed   Mentions:    Fields:    
    8. Heme Causes Pain in Sickle Mice via Toll-Like Receptor 4-Mediated Reactive Oxygen Species- and Endoplasmic Reticulum Stress-Induced Glial Activation. Antioxid Redox Signal. 2021 02 01; 34(4):279-293. Lei J, Paul J, Wang Y, Gupta M, Vang D, Thompson S, Jha R, Nguyen J, Valverde Y, Lamarre Y, Jones MK, Gupta K. PMID: 32729340.
      View in: PubMed   Mentions: 4     Fields:    
    9. Effect of Inhaled Cannabis for Pain in Adults With Sickle Cell Disease: A Randomized Clinical Trial. JAMA Netw Open. 2020 07 01; 3(7):e2010874. Abrams DI, Couey P, Dixit N, Sagi V, Hagar W, Vichinsky E, Kelly ME, Connett JE, Gupta K. PMID: 32678452.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Integrative approaches to treating pain in sickle cell disease: Pre-clinical and clinical evidence. Complement Ther Med. 2020 Jun; 51:102394. Sagi V, Argueta DA, Kiven S, Gupta K. PMID: 32507420.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    11. A Balanced Approach for Cannabidiol Use in Chronic Pain. Front Pharmacol. 2020; 11:561. Argueta DA, Ventura CM, Kiven S, Sagi V, Gupta K. PMID: 32425793.
      View in: PubMed   Mentions:
    12. End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain. Blood Adv. 2019 12 10; 3(23):3982-4001. Farrell AT, Panepinto J, Carroll CP, Darbari DS, Desai AA, King AA, Adams RJ, Barber TD, Brandow AM, DeBaun MR, Donahue MJ, Gupta K, Hankins JS, Kameka M, Kirkham FJ, Luksenburg H, Miller S, Oneal PA, Rees DC, Setse R, Sheehan VA, Strouse J, Stucky CL, Werner EM, Wood JC, Zempsky WT. PMID: 31809538.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    13. Substance P modulates electroacupuncture analgesia in humanized mice with sickle cell disease. J Pain Res. 2019; 12:2419-2426. Wang Y, Lei J, Jha RK, Kiven S, Gupta K. PMID: 31447579.
      View in: PubMed   Mentions:
    14. Pain and sickle cell disease. Curr Opin Hematol. 2019 05; 26(3):131-138. Aich A, Jones MK, Gupta K. PMID: 30893088.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    15. Effect of chronic opioid therapy on pain and survival in a humanized mouse model of sickle cell disease. Blood Adv. 2019 03 26; 3(6):869-873. Tran H, Sagi V, Leonce Song-Naba W, Wang Y, Mittal A, Lamarre Y, Zhang L, Gupta K. PMID: 30885998.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    16. Mast Cell Neural Interactions in Health and Disease. Front Cell Neurosci. 2019; 13:110. Mittal A, Sagi V, Gupta M, Gupta K. PMID: 30949032.
      View in: PubMed   Mentions:
    17. Sensitization of nociceptors by prostaglandin E2-glycerol contributes to hyperalgesia in mice with sickle cell disease. Blood. 2019 05 02; 133(18):1989-1998. Khasabova IA, Uhelski M, Khasabov SG, Gupta K, Seybold VS, Simone DA. PMID: 30796025.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    18. Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium. Front Cell Neurosci. 2019; 13:56. Tran H, Mittal A, Sagi V, Luk K, Nguyen A, Gupta M, Nguyen J, Lamarre Y, Lei J, Guedes A, Gupta K. PMID: 30837844.
      View in: PubMed   Mentions:
    19. Diet and gender influence survival of transgenic Berkley sickle cell mice. Haematologica. 2019 08; 104(8):e331-e334. Jahagirdar OB, Mittal AM, Song-Naba WL, Jha R, Kiven SB, Thompson ST, Connett JE, Gupta K. PMID: 30765475.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    20. Immune cell neural interactions and their contributions to sickle cell disease. Neurosci Lett. 2019 04 23; 699:167-171. Sagi V, Mittal A, Gupta M, Gupta K. PMID: 30738871.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Bartonella henselae Infection in Sickle Cell Disease Mice Is Associated with Hyperalgesia. Vector Borne Zoonotic Dis. 2019 Feb; 19(2):102-105. de Almeida AR, Vieira-Damiani G, da Silva MN, Lania BG, Soares TCB, Drummond MR, Lins KA, Ericson ME, Gupta K, Velho PENF. PMID: 30272535.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. Mouse Models of Pain in Sickle Cell Disease. Curr Protoc Neurosci. 2018 10; 85(1):e54. Sagi V, Song-Naba WL, Benson BA, Joshi SS, Gupta K. PMID: 30265442.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    23. Targeting pain at its source in sickle cell disease. . 2018 07 01; 315(1):R104-R112. Gupta K, Jahagirdar O, Gupta K. PMID: 29590553.
      View in: PubMed   Mentions:
    24. Targeting novel mechanisms of pain in sickle cell disease. Hematology Am Soc Hematol Educ Program. 2017 12 08; 2017(1):546-555. Tran H, Gupta M, Gupta K. PMID: 29222304.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Targeting novel mechanisms of pain in sickle cell disease. Blood. 2017 11 30; 130(22):2377-2385. Tran H, Gupta M, Gupta K. PMID: 29187376.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    26. Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis. Pain. 2017 Sep; 158(9):1711-1722. Uhelski ML, Gupta K, Simone DA. PMID: 28570479.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    27. A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade. Am J Hematol. 2017 Nov; 92(11):1119-1130. Solovey A, Somani A, Belcher JD, Milbauer L, Vincent L, Pawlinski R, Nath KA, Kelm RJ, Mackman N, O'Sullivan MG, Gupta K, Vercellotti GM, Hebbel RP. PMID: 28699284.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    28. Transcriptomic analysis of gene signatures associated with sickle pain. Sci Data. 2017 05 16; 4:170051. Paul JA, Aich A, Abrahante JE, Wang Y, LaRue RS, Rathe SK, Kalland K, Mittal A, Jha R, Peng F, Largaespada DA, Bagchi A, Gupta K. PMID: 29292796.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    29. Functional MRI BOLD response in sickle mice with hyperalgesia. Blood Cells Mol Dis. 2017 06; 65:81-85. Wang Y, Wang X, Chen W, Gupta K, Zhu XH. PMID: 28579187.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    30. Characterization of functional brain activity and connectivity using EEG and fMRI in patients with sickle cell disease. Neuroimage Clin. 2017; 14:1-17. Case M, Zhang H, Mundahl J, Datta Y, Nelson S, Gupta K, He B. PMID: 28116239.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    31. Electroacupuncture in conscious free-moving mice reduces pain by ameliorating peripheral and central nociceptive mechanisms. Sci Rep. 2016 Sep 30; 6:34493. Wang Y, Lei J, Gupta M, Peng F, Lam S, Jha R, Raduenz E, Beitz AJ, Gupta K. PMID: 27687125.
      View in: PubMed   Mentions: 9     Fields:    
    32. Comparative Analysis of Pain Behaviours in Humanized Mouse Models of Sickle Cell Anemia. PLoS One. 2016; 11(8):e0160608. Lei J, Benson B, Tran H, Ofori-Acquah SF, Gupta K. PMID: 27494522.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    33. Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease. Haematologica. 2016 10; 101(10):e397-e400. Nwankwo JO, Lei J, Xu J, Rivera A, Gupta K, Chishti AH. PMID: 27418647.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    34. Could Perioperative Opioid Use Increase the Risk of Cancer Progression and Metastases? Int Anesthesiol Clin. 2016; 54(4):e1-e16. Aich A, Gupta P, Gupta K. PMID: 27602710.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    35. Cannabinoid receptor-specific mechanisms to alleviate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation. Haematologica. 2016 05; 101(5):566-77. Vincent L, Vang D, Nguyen J, Benson B, Lei J, Gupta K. PMID: 26703965.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    36. Quantification of pain in sickle mice using facial expressions and body measurements. Blood Cells Mol Dis. 2016 Mar; 57:58-66. Mittal A, Gupta M, Lamarre Y, Jahagirdar B, Gupta K. PMID: 26852657.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    37. Mast Cell-Mediated Mechanisms of Nociception. Int J Mol Sci. 2015 Dec 04; 16(12):29069-92. Aich A, Afrin LB, Gupta K. PMID: 26690128.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    38. Spinal glial activation and oxidative stress are alleviated by treatment with curcumin or coenzyme Q in sickle mice. Haematologica. 2016 Feb; 101(2):e44-7. Valverde Y, Benson B, Gupta M, Gupta K. PMID: 26546503.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    39. Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease. Pain. 2015 Apr; 156(4):722-730. Cataldo G, Rajput S, Gupta K, Simone DA. PMID: 25630029.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    40. Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene. Cell Rep. 2014 Sep 11; 8(5):1484-96. Dandapat A, Bosnakovski D, Hartweck LM, Arpke RW, Baltgalvis KA, Vang D, Baik J, Darabi R, Perlingeiro RC, Hamra FK, Gupta K, Lowe DA, Kyba M. PMID: 25176645.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    41. Mast cell activation contributes to sickle cell pathobiology and pain in mice. Blood. 2013 Sep 12; 122(11):1853-62. Vincent L, Vang D, Nguyen J, Gupta M, Luk K, Ericson ME, Simone DA, Gupta K. PMID: 23775718.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    42. Carbon-fiber microelectrode amperometry reveals sickle-cell-induced inflammation and chronic morphine effects on single mast cells. ACS Chem Biol. 2012 Mar 16; 7(3):543-51. Manning BM, Hebbel RP, Gupta K, Haynes CL. PMID: 22217155.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    43. Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness. Br J Haematol. 2012 Feb; 156(4):535-44. Cain DM, Vang D, Simone DA, Hebbel RP, Gupta K. PMID: 22171826.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    44. Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids. Blood. 2010 Jul 22; 116(3):456-65. Kohli DR, Li Y, Khasabov SG, Gupta P, Kehl LJ, Ericson ME, Nguyen J, Gupta V, Hebbel RP, Simone DA, Gupta K. PMID: 20304807.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    45. Endothelial nitric oxide synthase is dynamically expressed during bone marrow stem cell differentiation into endothelial cells. . 2007 Sep; 293(3):H1760-5. Liu Z, Jiang Y, Hao H, Gupta K, Xu J, Chu L, McFalls E, Zweier J, Verfaillie C, Bache RJ. PMID: 17545471.
      View in: PubMed   Mentions:
    46. Morphine stimulates vascular endothelial growth factor-like signaling in mouse retinal endothelial cells. Curr Neurovasc Res. 2006 Aug; 3(3):171-80. Chen C, Farooqui M, Gupta K. PMID: 16918381.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
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