Moti L Kashyap

Title(s)Emeritus Faculty, Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(562) 826-5844, 5748
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    1. Testosterone concentrations and risk of cardiovascular events in androgen-deficient men with atherosclerotic cardiovascular disease. Am Heart J. 2020 06; 224:65-76. Boden WE, Miller MG, McBride R, Harvey C, Snabes MC, Schmidt J, McGovern ME, Fleg JL, Desvigne-Nickens P, Anderson T, Kashyap M, Probstfield JL. PMID: 32335402.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. Niacin for treatment of nonalcoholic fatty liver disease (NAFLD): novel use for an old drug? J Clin Lipidol. 2019 Nov - Dec; 13(6):873-879. Kashyap ML, Ganji S, Nakra NK, Kamanna VS. PMID: 31706905.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    3. Association of Serum Paraoxonase/Arylesterase Activity With All-Cause Mortality in Maintenance Hemodialysis Patients. J Clin Endocrinol Metab. 2019 10 01; 104(10):4848-4856. Suematsu Y, Goto M, Park C, Nunes ACF, Jing W, Streja E, Rhee CM, Cruz S, Kashyap ML, Vaziri ND, Narayanaswami V, Kalantar-Zadeh K, Moradi H. PMID: 30920627.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    4. Serum Endocannabinoid Levels in Patients With End-Stage Renal Disease. J Endocr Soc. 2019 Oct 01; 3(10):1869-1880. Moradi H, Park C, Igarashi M, Streja E, Argueta DA, Soohoo M, Daglian J, You AS, Rhee CM, Kashyap ML, DiPatrizio NV, Vaziri ND, Kalantar-Zadeh K, Piomelli D. PMID: 31583368.
      View in: PubMed   Mentions:
    5. Effects of Extended-Release Niacin on Quartile Lp-PLA2 Levels and Clinical Outcomes in Statin-treated Patients with Established Cardiovascular Disease and Low Baseline Levels of HDL-Cholesterol: Post Hoc Analysis of the AIM HIGH Trial. J Cardiovasc Pharmacol Ther. 2019 11; 24(6):534-541. Lyubarova R, Albers JJ, Marcovina SM, Yao Y, McBride R, Topliceanu A, Anderson T, Fleg JL, Desvigne-Nickens P, Kashyap ML, McGovern ME, Boden WE. PMID: 31131629.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Statin Therapy Before Transition to End-Stage Renal Disease With Posttransition Outcomes. J Am Heart Assoc. 2019 03 19; 8(6):e011869. Soohoo M, Moradi H, Obi Y, Rhee CM, Gosmanova EO, Molnar MZ, Kashyap ML, Gillen DL, Kovesdy CP, Kalantar-Zadeh K, Streja E. PMID: 30885048.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Cardiovascular outcomes during extended follow-up of the AIM-HIGH trial cohort. J Clin Lipidol. 2018 Nov - Dec; 12(6):1413-1419. Probstfield JL, Boden WE, Anderson T, Branch K, Kashyap M, Fleg JL, Desvigne-Nickens P, McBride R, McGovern M, AIM-HIGH Investigators . PMID: 30131256.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Inverse Association Between Serum Non-High-Density Lipoprotein Cholesterol Levels and Mortality in Patients Undergoing Incident Hemodialysis. J Am Heart Assoc. 2018 06 09; 7(12). Chang TI, Streja E, Ko GJ, Naderi N, Rhee CM, Kovesdy CP, Kashyap ML, Vaziri ND, Kalantar-Zadeh K, Moradi H. PMID: 29886420.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    9. Increments in serum high-density lipoprotein cholesterol over time are not associated with improved outcomes in incident hemodialysis patients. J Clin Lipidol. 2018 Mar - Apr; 12(2):488-497. Chang TI, Streja E, Soohoo M, Ko GJ, Rhee CM, Kovesdy CP, Kashyap ML, Vaziri ND, Kalantar-Zadeh K, Moradi H. PMID: 29456130.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. LCZ696 (Sacubitril/Valsartan), an Angiotensin-Receptor Neprilysin Inhibitor, Attenuates Cardiac Hypertrophy, Fibrosis, and Vasculopathy in a Rat Model of Chronic Kidney Disease. J Card Fail. 2018 Apr; 24(4):266-275. Suematsu Y, Jing W, Nunes A, Kashyap ML, Khazaeli M, Vaziri ND, Moradi H. PMID: 29325796.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    11. Association of Serum Triglyceride to HDL Cholesterol Ratio with All-Cause and Cardiovascular Mortality in Incident Hemodialysis Patients. Clin J Am Soc Nephrol. 2017 Apr 03; 12(4):591-602. Chang TI, Streja E, Soohoo M, Kim TW, Rhee CM, Kovesdy CP, Kashyap ML, Vaziri ND, Kalantar-Zadeh K, Moradi H. PMID: 28193609.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    12. Reverse Epidemiology of Traditional Cardiovascular Risk Factors in the Geriatric Population. J Am Med Dir Assoc. 2015 Nov 01; 16(11):933-9. Ahmadi SF, Streja E, Zahmatkesh G, Streja D, Kashyap M, Moradi H, Molnar MZ, Reddy U, Amin AN, Kovesdy CP, Kalantar-Zadeh K. PMID: 26363864.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    13. Association of serum lipids with outcomes in Hispanic hemodialysis patients of the West versus East Coasts of the United States. Am J Nephrol. 2015; 41(4-5):284-95. Moradi H, Abhari P, Streja E, Kashyap ML, Shah G, Gillen D, Pahl MV, Vaziri ND, Kalantar-Zadeh K. PMID: 26044456.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease. Metabolism. 2015 Sep; 64(9):982-90. Ganji SH, Kashyap ML, Kamanna VS. PMID: 26024755.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    15. Niacin and progression of CKD. Am J Kidney Dis. 2015 May; 65(5):785-98. Streja E, Kovesdy CP, Streja DA, Moradi H, Kalantar-Zadeh K, Kashyap ML. PMID: 25708553.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    16. Safety profile of extended-release niacin in the AIM-HIGH trial. N Engl J Med. 2014 Jul 17; 371(3):288-90. Anderson TJ, Boden WE, Desvigne-Nickens P, Fleg JL, Kashyap ML, McBride R, Probstfield JL, AIM-HIGH Investigators . PMID: 25014706.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    17. Niacin decreases leukocyte myeloperoxidase: mechanistic role of redox agents and Src/p38MAP kinase. Atherosclerosis. 2014 Aug; 235(2):554-61. Ganji SH, Kamanna VS, Kashyap ML. PMID: 24956528.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Elevated high-density lipoprotein cholesterol and cardiovascular mortality in maintenance hemodialysis patients. Nephrol Dial Transplant. 2014 Aug; 29(8):1554-62. Moradi H, Streja E, Kashyap ML, Vaziri ND, Fonarow GC, Kalantar-Zadeh K. PMID: 24574544.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    19. Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15; 306(4):G320-7. Ganji SH, Kukes GD, Lambrecht N, Kashyap ML, Kamanna VS. PMID: 24356885.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    20. Relationship of apolipoproteins A-1 and B, and lipoprotein(a) to cardiovascular outcomes: the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglyceride and Impact on Global Health Outcomes). J Am Coll Cardiol. 2013 Oct 22; 62(17):1575-9. Albers JJ, Slee A, O'Brien KD, Robinson JG, Kashyap ML, Kwiterovich PO, Xu P, Marcovina SM. PMID: 23973688.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    21. Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes). J Am Coll Cardiol. 2013 Oct 22; 62(17):1580-4. Guyton JR, Slee AE, Anderson T, Fleg JL, Goldberg RB, Kashyap ML, Marcovina SM, Nash SD, O'Brien KD, Weintraub WS, Xu P, Zhao XQ, Boden WE. PMID: 23916935.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    22. Mammalian colonocytes possess a carrier-mediated mechanism for uptake of vitamin B3 (niacin): studies utilizing human and mouse colonic preparations. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 01; 305(3):G207-13. Kumar JS, Subramanian VS, Kapadia R, Kashyap ML, Said HM. PMID: 23744738.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    23. Recent advances in niacin and lipid metabolism. Curr Opin Lipidol. 2013 Jun; 24(3):239-45. Kamanna VS, Ganji SH, Kashyap ML. PMID: 23619367.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    24. Role of HDL dysfunction in end-stage renal disease: a double-edged sword. J Ren Nutr. 2013 May; 23(3):203-6. Moradi H, Vaziri ND, Kashyap ML, Said HM, Kalantar-Zadeh K. PMID: 23611547.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    25. Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells. J Lipid Res. 2012 May; 53(5):941-950. Zhang LH, Kamanna VS, Ganji SH, Xiong XM, Kashyap ML. PMID: 22389325.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    26. Reverse D4F, an apolipoprotein-AI mimetic peptide, inhibits atherosclerosis in ApoE-null mice. J Cardiovasc Pharmacol Ther. 2012 Sep; 17(3):334-43. Qin S, Kamanna VS, Lai JH, Liu T, Ganji SH, Zhang L, Bachovchin WW, Kashyap ML. PMID: 22308547.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. Niacin extended-release therapy in phase III clinical trials is associated with relatively low rates of drug discontinuation due to flushing and treatment-related adverse events: a pooled analysis. Am J Cardiovasc Drugs. 2011 Jun 01; 11(3):179-87. Brinton EA, Kashyap ML, Vo AN, Thakkar RB, Jiang P, Padley RJ. PMID: 21619381.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    28. Pioglitazone increases apolipoprotein A-I production by directly enhancing PPRE-dependent transcription in HepG2 cells. J Lipid Res. 2010 Aug; 51(8):2211-22. Zhang LH, Kamanna VS, Ganji SH, Xiong XM, Kashyap ML. PMID: 20371549.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    29. Acetylsalicylic acid reduces niacin extended-release-induced flushing in patients with dyslipidemia. Am J Cardiovasc Drugs. 2009; 9(2):69-79. Thakkar RB, Kashyap ML, Lewin AJ, Krause SL, Jiang P, Padley RJ. PMID: 19331435.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    30. Niacin: an old drug rejuvenated. Curr Atheroscler Rep. 2009 Jan; 11(1):45-51. Kamanna VS, Ganji SH, Kashyap ML. PMID: 19080727.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    31. Fixed-dose combination of extended-release niacin plus simvastatin for lipid disorders. Expert Rev Cardiovasc Ther. 2008 Nov; 6(10):1303-10. Vo AN, Kashyap ML. PMID: 19018682.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    32. Efficacy and safety of ABT-335 (fenofibric acid) in combination with rosuvastatin in patients with mixed dyslipidemia: a phase 3 study. Atherosclerosis. 2009 May; 204(1):208-15. Jones PH, Davidson MH, Kashyap ML, Kelly MT, Buttler SM, Setze CM, Sleep DJ, Stolzenbach JC. PMID: 18996523.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCTClinical Trials
    33. Rosuvastatin selectively stimulates apolipoprotein A-I but not apolipoprotein A-II synthesis in Hep G2 cells. Metabolism. 2008 Jul; 57(7):973-9. Qin S, Koga T, Ganji SH, Kamanna VS, Kashyap ML. PMID: 18555840.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    34. Nicotinic acid: recent developments. Curr Opin Cardiol. 2008 Jul; 23(4):393-8. Kamanna VS, Vo A, Kashyap ML. PMID: 18520725.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    35. Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells. Atherosclerosis. 2009 Jan; 202(1):68-75. Ganji SH, Qin S, Zhang L, Kamanna VS, Kashyap ML. PMID: 18550065.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    36. Mechanism of action of niacin. Am J Cardiol. 2008 Apr 17; 101(8A):20B-26B. Kamanna VS, Kashyap ML. PMID: 18375237.
      View in: PubMed   Mentions: 82     Fields:    Translation:Humans
    37. Niacin inhibits surface expression of ATP synthase beta chain in HepG2 cells: implications for raising HDL. J Lipid Res. 2008 Jun; 49(6):1195-201. Zhang LH, Kamanna VS, Zhang MC, Kashyap ML. PMID: 18316796.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    38. Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS study. Am J Cardiovasc Drugs. 2008; 8(2):69-81. Karas RH, Kashyap ML, Knopp RH, Keller LH, Bajorunas DR, Davidson MH. PMID: 18422390.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    39. Nicotinic acid (niacin) receptor agonists: will they be useful therapeutic agents? Am J Cardiol. 2007 Dec 03; 100(11 A):S53-61. Kamanna VS, Kashyap ML. PMID: 18047854.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    40. Mechanism of nicotinic acid transport in human liver cells: experiments with HepG2 cells and primary hepatocytes. . 2007 Dec; 293(6):C1773-8. Said HM, Nabokina SM, Balamurugan K, Mohammed ZM, Urbina C, Kashyap ML. PMID: 17928533.
      View in: PubMed   Mentions:
    41. Pioglitazone stimulates apolipoprotein A-I production without affecting HDL removal in HepG2 cells: involvement of PPAR-alpha. Arterioscler Thromb Vasc Biol. 2007 Nov; 27(11):2428-34. Qin S, Liu T, Kamanna VS, Kashyap ML. PMID: 17872455.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    42. Comparative effects on lipid levels of combination therapy with a statin and extended-release niacin or ezetimibe versus a statin alone (the COMPELL study). Atherosclerosis. 2007 Jun; 192(2):432-7. McKenney JM, Jones PH, Bays HE, Knopp RH, Kashyap ML, Ruoff GE, McGovern ME. PMID: 17239888.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    43. Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush. Atherosclerosis. 2007 Jun; 192(2):253-8. Meyers CD, Liu P, Kamanna VS, Kashyap ML. PMID: 16945375.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    44. Baseline achievement of lipid goals and usage of lipid medications in patients with diabetes mellitus (from the Veterans Affairs Diabetes Trial). Am J Cardiol. 2006 Jul 01; 98(1):63-5. Meyers CD, McCarren M, Wong ND, Abraira C, Duckworth WC, Kashyap ML, VADT Investigators . PMID: 16784922.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    45. Anticipating the evolution of clinical cholesterol guidelines: implications of recent statin intervention trials. Future Cardiol. 2005 Jul; 1(4):461-71. Meyers CD, Wong N, Kashyap ML. PMID: 19804146.
      View in: PubMed   Mentions:    Fields:    
    46. Pharmacologic augmentation of high-density lipoproteins: mechanisms of currently available and emerging therapies. Curr Opin Cardiol. 2005 Jul; 20(4):307-12. Meyers CD, Kashyap ML. PMID: 15956828.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    47. Mechanism and regulation of human intestinal niacin uptake. . 2005 Jul; 289(1):C97-103. Nabokina SM, Kashyap ML, Said HM. PMID: 15728713.
      View in: PubMed   Mentions:
    48. Niacin therapy in atherosclerosis. Curr Opin Lipidol. 2004 Dec; 15(6):659-65. Meyers CD, Kamanna VS, Kashyap ML. PMID: 15529025.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    49. Pharmacologic treatment of type 2 diabetic dyslipidemia. Pharmacotherapy. 2004 Dec; 24(12):1692-713. Moon YS, Kashyap ML. PMID: 15585439.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    50. Management of the metabolic syndrome-nicotinic acid. Endocrinol Metab Clin North Am. 2004 Sep; 33(3):557-75, vii. Meyers CD, Kashyap ML. PMID: 15262297.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    51. Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. J Lipid Res. 2004 Oct; 45(10):1835-45. Ganji SH, Tavintharan S, Zhu D, Xing Y, Kamanna VS, Kashyap ML. PMID: 15258194.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    52. Pharmacologic elevation of high-density lipoproteins: recent insights on mechanism of action and atherosclerosis protection. Curr Opin Cardiol. 2004 Jul; 19(4):366-73. Meyers CD, Kashyap ML. PMID: 15218398.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    53. Niacin, lipids, and heart disease. Curr Cardiol Rep. 2003 Nov; 5(6):470-6. Malik S, Kashyap ML. PMID: 14558989.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    54. Niacin and cholesterol: role in cardiovascular disease (review). J Nutr Biochem. 2003 Jun; 14(6):298-305. Ganji SH, Kamanna VS, Kashyap ML. PMID: 12873710.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    55. Dyslipidemia treatment: current considerations and unmet needs. Expert Rev Cardiovasc Ther. 2003 May; 1(1):121-34. Malik S, Kashyap ML. PMID: 15030302.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    56. Comparison of once-daily, niacin extended-release/lovastatin with standard doses of atorvastatin and simvastatin (the ADvicor Versus Other Cholesterol-Modulating Agents Trial Evaluation [ADVOCATE]). Am J Cardiol. 2003 Mar 15; 91(6):667-72. Bays HE, Dujovne CA, McGovern ME, White TE, Kashyap ML, Hutcheson AG, Crouse JR, ADvicor Versus Other Cholesterol-Modulating Agents Trial Evaluation . PMID: 12633795.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    57. Optimal therapy of low levels of high density lipoprotein-cholesterol. Am J Cardiovasc Drugs. 2003; 3(1):53-65. Kashyap ML, Tavintharan S, Kamanna VS. PMID: 14727946.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    58. Niacin extended-release/lovastatin: combination therapy for lipid disorders. Expert Opin Pharmacother. 2002 Dec; 3(12):1763-71. Moon YS, Kashyap ML. PMID: 12472373.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    59. Effect of gemfibrozil on apolipoprotein B secretion and diacylglycerol acyltransferase activity in human hepatoblastoma (HepG2) cells. Atherosclerosis. 2002 Oct; 164(2):221-8. Zhu D, Ganji SH, Kamanna VS, Kashyap ML. PMID: 12204791.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    60. Long-term safety and efficacy of a once-daily niacin/lovastatin formulation for patients with dyslipidemia. Am J Cardiol. 2002 Mar 15; 89(6):672-8. Kashyap ML, McGovern ME, Berra K, Guyton JR, Kwiterovich PO, Harper WL, Toth PD, Favrot LK, Kerzner B, Nash SD, Bays HE, Simmons PD. PMID: 11897208.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
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