Mahler, Stephen V.

TitleAssistant Professor
InstitutionUniversity of California, Irvine
DepartmentNeurobiology & Behavior
Address1203 McGaugh Hall
Zot 4550
Irvine CA 92697
Phone(949) 824-6128
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of Ventral Pallidum Projection to VTA in Reinstatement of Cocaine Seeking
    NIH/NIDA R00DA035251Jun 15, 2015 - Mar 31, 2018
    Role: Principal Investigator
    Role of Ventral Pallidum Projection to VTA in Reinstatement of Cocaine Seeking
    NIH/NIDA K99DA035251Apr 1, 2013 - Mar 31, 2015
    Role: Principal Investigator
    VTA Glutamate and Orexin Involvement in Cue Reinstatement of Drug Seeking
    NIH/NIDA F32DA026692Jan 25, 2010 - Jan 24, 2013
    Role: Principal Investigator
    Opioid Modulation of Cue-Triggered 'Wanting' in Amygdala
    NIH/NIDA F31DA021481Sep 30, 2006 - Sep 29, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mahler SV, Brodnik ZD, Cox BM, Buchta WC, Bentzley BS, Quintanilla J, Cope ZA, Lin EC, Riedy MD, Scofield MD, Messinger J, Ruiz CM, Riegel AC, EspaƱa RA, Aston-Jones G. Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse. J Neurosci. 2018 Nov 16. PMID: 30446532.
      View in: PubMed
    2. Mitchell MR, Berridge KC, Mahler SV. Endocannabinoid-Enhanced "Liking" in Nucleus Accumbens Shell Hedonic Hotspot Requires Endogenous Opioid Signals. Cannabis Cannabinoid Res. 2018; 3(1):166-170. PMID: 30069500.
      View in: PubMed
    3. Mahler SV. Author Correction: Stay alert, don't get hurt. Nat Neurosci. 2018 May 11. PMID: 29752480.
      View in: PubMed
    4. Mahler SV, Aston-Jones G. CNO Evil? Considerations for the Use of DREADDs in Behavioral Neuroscience. Neuropsychopharmacology. 2018 Apr; 43(5):934-936. PMID: 29303143.
      View in: PubMed
    5. Bolton JL, Ruiz CM, Rismanchi N, Sanchez GA, Castillo E, Huang J, Cross C, Baram TZ, Mahler SV. Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia. Neurobiol Stress. 2018 Feb; 8:57-67. PMID: 29888304.
      View in: PubMed
    6. Farrell MR, Schoch H, Mahler SV. Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 03. PMID: 29305936.
      View in: PubMed
    7. Mahler SV. Stay alert, don't get hurt. Nat Neurosci. 2018 Jan; 21(1):3-5. PMID: 29269760.
      View in: PubMed
    8. James MH, McGlinchey EM, Vattikonda A, Mahler SV, Aston-Jones G. Cued Reinstatement of Cocaine but Not Sucrose Seeking Is Dependent on Dopamine Signaling in Prelimbic Cortex and Is Associated with Recruitment of Prelimbic Neurons That Project to Contralateral Nucleus Accumbens Core. Int J Neuropsychopharmacol. 2018 Jan 01; 21(1):89-94. PMID: 29165565.
      View in: PubMed
    9. Buchta WC, Mahler SV, Harlan B, Aston-Jones GS, Riegel AC. Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex. Physiol Rep. 2017 Mar; 5(6). PMID: 28325790.
      View in: PubMed
    10. James MH, Mahler SV, Moorman DE, Aston-Jones G. A Decade of Orexin/Hypocretin and Addiction: Where Are We Now? Curr Top Behav Neurosci. 2017; 33:247-281. PMID: 28012090.
      View in: PubMed
    11. McGlinchey EM, James MH, Mahler SV, Pantazis C, Aston-Jones G. Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking. J Neurosci. 2016 08 17; 36(33):8700-11. PMID: 27535915; PMCID: PMC4987439 [Available on 02/17/17].
    12. Smith KS, Bucci DJ, Luikart BW, Mahler SV. DREADDS: Use and application in behavioral neuroscience. Behav Neurosci. 2016 Apr; 130(2):137-55. PMID: 26913540; PMCID: PMC4792665 [Available on 04/01/17].
    13. Mahler SV, Moorman DE, Smith RJ, James MH, Aston-Jones G. Motivational activation: a unifying hypothesis of orexin/hypocretin function. Nat Neurosci. 2014 Oct; 17(10):1298-303. PMID: 25254979; PMCID: PMC4335648.
    14. Mahler SV, Vazey EM, Beckley JT, Keistler CR, McGlinchey EM, Kaufling J, Wilson SP, Deisseroth K, Woodward JJ, Aston-Jones G. Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking. Nat Neurosci. 2014 Apr; 17(4):577-85. PMID: 24584054; PMCID: PMC3973180.
    15. Mahler SV, Hensley-Simon M, Tahsili-Fahadan P, LaLumiere RT, Thomas C, Fallon RV, Kalivas PW, Aston-Jones G. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Addict Biol. 2014 Jan; 19(1):49-60. PMID: 23017017; PMCID: PMC3535502.
    16. Mahler SV, Aston-Jones GS. Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats. J Neurosci. 2012 Sep 19; 32(38):13309-26. PMID: 22993446; PMCID: PMC3480730.
    17. Mahler SV, Moorman DE, Feltenstein MW, Cox BM, Ogburn KB, Bachar M, McGonigal JT, Ghee SM, See RE. A rodent "self-report" measure of methamphetamine craving? Rat ultrasonic vocalizations during methamphetamine self-administration, extinction, and reinstatement. Behav Brain Res. 2013 Jan 01; 236(1):78-89. PMID: 22940018; PMCID: PMC3482304.
    18. Mahler SV, Smith RJ, Aston-Jones G. Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl). 2013 Apr; 226(4):687-98. PMID: 22411428; PMCID: PMC3649073.
    19. Mahler SV, Smith RJ, Moorman DE, Sartor GC, Aston-Jones G. Multiple roles for orexin/hypocretin in addiction. Prog Brain Res. 2012; 198:79-121. PMID: 22813971; PMCID: PMC3643893.
    20. Mahler SV, Berridge KC. What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex. Psychopharmacology (Berl). 2012 Jun; 221(3):407-26. PMID: 22167254; PMCID: PMC3444284.
    21. Mahler SV, de Wit H. Cue-reactors: individual differences in cue-induced craving after food or smoking abstinence. PLoS One. 2010 Nov 10; 5(11):e15475. PMID: 21085667; PMCID: PMC2978100.
    22. Mahler SV, Berridge KC. Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue. J Neurosci. 2009 May 20; 29(20):6500-13. PMID: 19458221; PMCID: PMC2802210.
    23. Mahler SV, Smith KS, Berridge KC. Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. Neuropsychopharmacology. 2007 Nov; 32(11):2267-78. PMID: 17406653.
      View in: PubMed
    24. Acheson A, Mahler SV, Chi H, de Wit H. Differential effects of nicotine on alcohol consumption in men and women. Psychopharmacology (Berl). 2006 May; 186(1):54-63. PMID: 16565827.
      View in: PubMed
    25. Alsene KM, Mahler SV, de Wit H. Effects of d-amphetamine and smoking abstinence on cue-induced cigarette craving. Exp Clin Psychopharmacol. 2005 Aug; 13(3):209-18. PMID: 16173884.
      View in: PubMed
    26. Young EM, Mahler S, Chi H, de Wit H. Mecamylamine and ethanol preference in healthy volunteers. Alcohol Clin Exp Res. 2005 Jan; 29(1):58-65. PMID: 15654292.
      View in: PubMed
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