Stephen V. Mahler

Title(s)Assistant Professor, Neurobiology & Behavior
Address1203 McGaugh Hall
Zot 4550
Irvine CA 92697
Phone(949) 824-6128
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    Role of Ventral Pallidum Projection to VTA in Reinstatement of Cocaine Seeking
    NIH R00DA035251Jun 15, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Role of Ventral Pallidum Projection to VTA in Reinstatement of Cocaine Seeking
    NIH K99DA035251Apr 1, 2013 - Mar 31, 2015
    Role: Principal Investigator
    VTA Glutamate and Orexin Involvement in Cue Reinstatement of Drug Seeking
    NIH F32DA026692Jan 25, 2010 - Jan 24, 2013
    Role: Principal Investigator
    Opioid Modulation of Cue-Triggered 'Wanting' in Amygdala
    NIH F31DA021481Sep 30, 2006 - Sep 29, 2009
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction. Eur J Neurosci. 2021 Apr 07. Levis SC, Baram TZ, Mahler SV. PMID: 33825217.
      View in: PubMed   Mentions:    Fields:    
    2. Ventral Pallidum GABA Neurons Mediate Motivation Underlying Risky Choice. J Neurosci. 2021 Apr 06. Farrell MR, Esteban JSD, Faget L, Floresco SB, Hnasko TS, Mahler SV. PMID: 33837052.
      View in: PubMed   Mentions:    Fields:    
    3. Dreadds: Use and application in behavioral neuroscience. Behav Neurosci. 2021 Apr; 135(2):89-107. Smith KS, Bucci DJ, Luikart BW, Mahler SV. PMID: 34060867.
      View in: PubMed   Mentions:    Fields:    
    4. Retrograde enhancement of episodic learning by a postlearning stimulus. Learn Mem. 2021 03; 28(3):82-86. Quintanilla J, Cox BM, Gall CM, Mahler SV, Lynch G. PMID: 33593926.
      View in: PubMed   Mentions:    Fields:    
    5. The Developmental Origins of Opioid Use Disorder and Its Comorbidities. Front Hum Neurosci. 2021; 15:601905. Levis SC, Mahler SV, Baram TZ. PMID: 33643011.
      View in: PubMed   Mentions:
    6. Chemogenetic Manipulation of Dopamine Neurons Dictates Cocaine Potency at Distal Dopamine Transporters. J Neurosci. 2020 11 04; 40(45):8767-8779. Brodnik ZD, Xu W, Batra A, Lewandowski SI, Ruiz CM, Mortensen OV, Kortagere S, Mahler SV, España RA. PMID: 33046544.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Pharmacokinetic, behavioral, and brain activity effects of ?9-tetrahydrocannabinol in adolescent male and female rats. Neuropsychopharmacology. 2021 04; 46(5):959-969. Ruiz CM, Torrens A, Castillo E, Perrone CR, Cevallos J, Inshishian VC, Harder EV, Justeson DN, Huestis MA, Swarup V, Piomelli D, Mahler SV. PMID: 32927465.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    8. Comparative Pharmacokinetics of ?9-Tetrahydrocannabinol in Adolescent and Adult Male Mice. J Pharmacol Exp Ther. 2020 07; 374(1):151-160. Torrens A, Vozella V, Huff H, McNeil B, Ahmed F, Ghidini A, Mahler SV, Huestis MA, Das A, Piomelli D. PMID: 32345621.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Do striatal push/pull circuits hold the key to compulsive, relapsing heroin addiction? : A Research Highlight on: Chemogenetic modulation of accumbens direct or indirect pathways bidirectionally alters reinstatement of heroin-seeking in high- but not low-risk rats, by O'Neal et al. (2019). Neuropsychopharmacology. 2020 07; 45(8):1243-1244. James MH, Mahler SV. PMID: 31974443.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. On the early life origins of vulnerability to opioid addiction. Mol Psychiatry. 2019 Dec 10. Levis SC, Bentzley BS, Molet J, Bolton JL, Perrone CR, Baram TZ, Mahler SV. PMID: 31822817.
      View in: PubMed   Mentions: 5     Fields:    
    11. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat Commun. 2019 10 11; 10(1):4627. Bonaventura J, Eldridge MAG, Hu F, Gomez JL, Sanchez-Soto M, Abramyan AM, Lam S, Boehm MA, Ruiz C, Farrell MR, Moreno A, Galal Faress IM, Andersen N, Lin JY, Moaddel R, Morris PJ, Shi L, Sibley DR, Mahler SV, Nabavi S, Pomper MG, Bonci A, Horti AG, Richmond BJ, Michaelides M. PMID: 31604917.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    12. Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats. Neuropsychopharmacology. 2019 12; 44(13):2174-2185. Farrell MR, Ruiz CM, Castillo E, Faget L, Khanbijian C, Liu S, Schoch H, Rojas G, Huerta MY, Hnasko TS, Mahler SV. PMID: 31476762.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    13. Prefrontal Pathways Provide Top-Down Control of Memory for Sequences of Events. Cell Rep. 2019 07 16; 28(3):640-654.e6. Jayachandran M, Linley SB, Schlecht M, Mahler SV, Vertes RP, Allen TA. PMID: 31315044.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    14. Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats. Elife. 2019 05 20; 8. Halbout B, Marshall AT, Azimi A, Liljeholm M, Mahler SV, Wassum KM, Ostlund SB. PMID: 31107241.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse. J Neurosci. 2019 01 16; 39(3):503-518. Mahler SV, Brodnik ZD, Cox BM, Buchta WC, Bentzley BS, Quintanilla J, Cope ZA, Lin EC, Riedy MD, Scofield MD, Messinger J, Ruiz CM, Riegel AC, España RA, Aston-Jones G. PMID: 30446532.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    16. Endocannabinoid-Enhanced "Liking" in Nucleus Accumbens Shell Hedonic Hotspot Requires Endogenous Opioid Signals. Cannabis Cannabinoid Res. 2018; 3(1):166-170. Mitchell MR, Berridge KC, Mahler SV. PMID: 30069500.
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    17. Author Correction: Stay alert, don't get hurt. Nat Neurosci. 2018 Jun; 21(6):894. Mahler SV. PMID: 29752480.
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    18. CNO Evil? Considerations for the Use of DREADDs in Behavioral Neuroscience. Neuropsychopharmacology. 2018 04; 43(5):934-936. Mahler SV, Aston-Jones G. PMID: 29303143.
      View in: PubMed   Mentions: 42     Fields:    
    19. Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia. Neurobiol Stress. 2018 Feb; 8:57-67. Bolton JL, Ruiz CM, Rismanchi N, Sanchez GA, Castillo E, Huang J, Cross C, Baram TZ, Mahler SV. PMID: 29888304.
      View in: PubMed   Mentions:
    20. Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms. Prog Neuropsychopharmacol Biol Psychiatry. 2018 12 20; 87(Pt A):33-47. Farrell MR, Schoch H, Mahler SV. PMID: 29305936.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    21. Cued Reinstatement of Cocaine but Not Sucrose Seeking Is Dependent on Dopamine Signaling in Prelimbic Cortex and Is Associated with Recruitment of Prelimbic Neurons That Project to Contralateral Nucleus Accumbens Core. Int J Neuropsychopharmacol. 2018 01 01; 21(1):89-94. James MH, McGlinchey EM, Vattikonda A, Mahler SV, Aston-Jones G. PMID: 29165565.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    22. Stay alert, don't get hurt. Nat Neurosci. 2018 01; 21(1):3-5. Mahler SV. PMID: 29269760.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    23. Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex. Physiol Rep. 2017 Mar; 5(6). Buchta WC, Mahler SV, Harlan B, Aston-Jones GS, Riegel AC. PMID: 28325790.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    24. A Decade of Orexin/Hypocretin and Addiction: Where Are We Now? Curr Top Behav Neurosci. 2017; 33:247-281. James MH, Mahler SV, Moorman DE, Aston-Jones G. PMID: 28012090.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    25. Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking. J Neurosci. 2016 08 17; 36(33):8700-11. McGlinchey EM, James MH, Mahler SV, Pantazis C, Aston-Jones G. PMID: 27535915.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    26. DREADDS: Use and application in behavioral neuroscience. Behav Neurosci. 2016 Apr; 130(2):137-55. Smith KS, Bucci DJ, Luikart BW, Mahler SV. PMID: 26913540.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    27. Motivational activation: a unifying hypothesis of orexin/hypocretin function. Nat Neurosci. 2014 Oct; 17(10):1298-303. Mahler SV, Moorman DE, Smith RJ, James MH, Aston-Jones G. PMID: 25254979.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimals
    28. Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking. Nat Neurosci. 2014 Apr; 17(4):577-85. Mahler SV, Vazey EM, Beckley JT, Keistler CR, McGlinchey EM, Kaufling J, Wilson SP, Deisseroth K, Woodward JJ, Aston-Jones G. PMID: 24584054.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    29. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Addict Biol. 2014 Jan; 19(1):49-60. Mahler SV, Hensley-Simon M, Tahsili-Fahadan P, LaLumiere RT, Thomas C, Fallon RV, Kalivas PW, Aston-Jones G. PMID: 23017017.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsPHPublic Health
    30. Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats. J Neurosci. 2012 Sep 19; 32(38):13309-26. Mahler SV, Aston-Jones GS. PMID: 22993446.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    31. A rodent "self-report" measure of methamphetamine craving? Rat ultrasonic vocalizations during methamphetamine self-administration, extinction, and reinstatement. Behav Brain Res. 2013 Jan 01; 236(1):78-89. Mahler SV, Moorman DE, Feltenstein MW, Cox BM, Ogburn KB, Bachar M, McGonigal JT, Ghee SM, See RE. PMID: 22940018.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    32. Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl). 2013 Apr; 226(4):687-98. Mahler SV, Smith RJ, Aston-Jones G. PMID: 22411428.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    33. Multiple roles for orexin/hypocretin in addiction. Prog Brain Res. 2012; 198:79-121. Mahler SV, Smith RJ, Moorman DE, Sartor GC, Aston-Jones G. PMID: 22813971.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimals
    34. What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex. Psychopharmacology (Berl). 2012 Jun; 221(3):407-26. Mahler SV, Berridge KC. PMID: 22167254.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    35. Cue-reactors: individual differences in cue-induced craving after food or smoking abstinence. PLoS One. 2010 Nov 10; 5(11):e15475. Mahler SV, de Wit H. PMID: 21085667.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCTClinical Trials
    36. Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue. J Neurosci. 2009 May 20; 29(20):6500-13. Mahler SV, Berridge KC. PMID: 19458221.
      View in: PubMed   Mentions: 86     Fields:    Translation:Animals
    37. Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. Neuropsychopharmacology. 2007 Nov; 32(11):2267-78. Mahler SV, Smith KS, Berridge KC. PMID: 17406653.
      View in: PubMed   Mentions: 134     Fields:    Translation:Animals
    38. Differential effects of nicotine on alcohol consumption in men and women. Psychopharmacology (Berl). 2006 May; 186(1):54-63. Acheson A, Mahler SV, Chi H, de Wit H. PMID: 16565827.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    39. Effects of d-amphetamine and smoking abstinence on cue-induced cigarette craving. Exp Clin Psychopharmacol. 2005 Aug; 13(3):209-18. Alsene KM, Mahler SV, de Wit H. PMID: 16173884.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCTClinical Trials
    40. Mecamylamine and ethanol preference in healthy volunteers. Alcohol Clin Exp Res. 2005 Jan; 29(1):58-65. Young EM, Mahler S, Chi H, de Wit H. PMID: 15654292.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCTClinical Trials
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