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Stephen V. Mahler

Title(s)Assistant Professor, Neurobiology & Behavior
Phone(949) 824-6128
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    Role of Ventral Pallidum Projection to VTA in Reinstatement of Cocaine Seeking
    NIH/NIDA R00DA035251Jun 15, 2015 - Mar 31, 2018
    Role: Principal Investigator
    Role of Ventral Pallidum Projection to VTA in Reinstatement of Cocaine Seeking
    NIH/NIDA K99DA035251Apr 1, 2013 - Mar 31, 2015
    Role: Principal Investigator
    VTA Glutamate and Orexin Involvement in Cue Reinstatement of Drug Seeking
    NIH/NIDA F32DA026692Jan 25, 2010 - Jan 24, 2013
    Role: Principal Investigator
    Opioid Modulation of Cue-Triggered 'Wanting' in Amygdala
    NIH/NIDA F31DA021481Sep 30, 2006 - Sep 29, 2009
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bonaventura J, Eldridge MAG, Hu F, Gomez JL, Sanchez-Soto M, Abramyan AM, Lam S, Boehm MA, Ruiz C, Farrell MR, Moreno A, Galal Faress IM, Andersen N, Lin JY, Moaddel R, Morris PJ, Shi L, Sibley DR, Mahler SV, Nabavi S, Pomper MG, Bonci A, Horti AG, Richmond BJ, Michaelides M. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat Commun. 2019 Oct 11; 10(1):4627. PMID: 31604917.
      View in: PubMed
    2. Farrell MR, Ruiz CM, Castillo E, Faget L, Khanbijian C, Liu S, Schoch H, Rojas G, Huerta MY, Hnasko TS, Mahler SV. Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats. Neuropsychopharmacology. 2019 Dec; 44(13):2174-2185. PMID: 31476762.
      View in: PubMed
    3. Jayachandran M, Linley SB, Schlecht M, Mahler SV, Vertes RP, Allen TA. Prefrontal Pathways Provide Top-Down Control of Memory for Sequences of Events. Cell Rep. 2019 Jul 16; 28(3):640-654.e6. PMID: 31315044.
      View in: PubMed
    4. Halbout B, Marshall AT, Azimi A, Liljeholm M, Mahler SV, Wassum KM, Ostlund SB. Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats. Elife. 2019 05 20; 8. PMID: 31107241.
      View in: PubMed
    5. Mahler SV, Brodnik ZD, Cox BM, Buchta WC, Bentzley BS, Quintanilla J, Cope ZA, Lin EC, Riedy MD, Scofield MD, Messinger J, Ruiz CM, Riegel AC, EspaƱa RA, Aston-Jones G. Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse. J Neurosci. 2019 01 16; 39(3):503-518. PMID: 30446532.
      View in: PubMed
    6. Mitchell MR, Berridge KC, Mahler SV. Endocannabinoid-Enhanced "Liking" in Nucleus Accumbens Shell Hedonic Hotspot Requires Endogenous Opioid Signals. Cannabis Cannabinoid Res. 2018; 3(1):166-170. PMID: 30069500.
      View in: PubMed
    7. Mahler SV. Author Correction: Stay alert, don't get hurt. Nat Neurosci. 2018 Jun; 21(6):894. PMID: 29752480.
      View in: PubMed
    8. Mahler SV, Aston-Jones G. CNO Evil? Considerations for the Use of DREADDs in Behavioral Neuroscience. Neuropsychopharmacology. 2018 04; 43(5):934-936. PMID: 29303143.
      View in: PubMed
    9. Bolton JL, Ruiz CM, Rismanchi N, Sanchez GA, Castillo E, Huang J, Cross C, Baram TZ, Mahler SV. Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia. Neurobiol Stress. 2018 Feb; 8:57-67. PMID: 29888304.
      View in: PubMed
    10. Farrell MR, Schoch H, Mahler SV. Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms. Prog Neuropsychopharmacol Biol Psychiatry. 2018 12 20; 87(Pt A):33-47. PMID: 29305936.
      View in: PubMed
    11. Mahler SV. Stay alert, don't get hurt. Nat Neurosci. 2018 01; 21(1):3-5. PMID: 29269760.
      View in: PubMed
    12. James MH, McGlinchey EM, Vattikonda A, Mahler SV, Aston-Jones G. Cued Reinstatement of Cocaine but Not Sucrose Seeking Is Dependent on Dopamine Signaling in Prelimbic Cortex and Is Associated with Recruitment of Prelimbic Neurons That Project to Contralateral Nucleus Accumbens Core. Int J Neuropsychopharmacol. 2018 01 01; 21(1):89-94. PMID: 29165565.
      View in: PubMed
    13. Schoch H, Huerta MY, Ruiz CM, Farrell MR, Jung KM, Huang JJ, Campbell RR, Piomelli D, Mahler SV. Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats. Psychopharmacology (Berl). 2018 01; 235(1):121-134. PMID: 29022083.
      View in: PubMed
    14. Buchta WC, Mahler SV, Harlan B, Aston-Jones GS, Riegel AC. Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex. Physiol Rep. 2017 Mar; 5(6). PMID: 28325790.
      View in: PubMed
    15. James MH, Mahler SV, Moorman DE, Aston-Jones G. A Decade of Orexin/Hypocretin and Addiction: Where Are We Now? Curr Top Behav Neurosci. 2017; 33:247-281. PMID: 28012090.
      View in: PubMed
    16. McGlinchey EM, James MH, Mahler SV, Pantazis C, Aston-Jones G. Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking. J Neurosci. 2016 08 17; 36(33):8700-11. PMID: 27535915.
      View in: PubMed
    17. Smith KS, Bucci DJ, Luikart BW, Mahler SV. DREADDS: Use and application in behavioral neuroscience. Behav Neurosci. 2016 Apr; 130(2):137-55. PMID: 26913540.
      View in: PubMed
    18. Mahler SV, Moorman DE, Smith RJ, James MH, Aston-Jones G. Motivational activation: a unifying hypothesis of orexin/hypocretin function. Nat Neurosci. 2014 Oct; 17(10):1298-303. PMID: 25254979.
      View in: PubMed
    19. Mahler SV, Vazey EM, Beckley JT, Keistler CR, McGlinchey EM, Kaufling J, Wilson SP, Deisseroth K, Woodward JJ, Aston-Jones G. Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking. Nat Neurosci. 2014 Apr; 17(4):577-85. PMID: 24584054.
      View in: PubMed
    20. Mahler SV, Hensley-Simon M, Tahsili-Fahadan P, LaLumiere RT, Thomas C, Fallon RV, Kalivas PW, Aston-Jones G. Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Addict Biol. 2014 Jan; 19(1):49-60. PMID: 23017017.
      View in: PubMed
    21. Mahler SV, Aston-Jones GS. Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats. J Neurosci. 2012 Sep 19; 32(38):13309-26. PMID: 22993446.
      View in: PubMed
    22. Mahler SV, Moorman DE, Feltenstein MW, Cox BM, Ogburn KB, Bachar M, McGonigal JT, Ghee SM, See RE. A rodent "self-report" measure of methamphetamine craving? Rat ultrasonic vocalizations during methamphetamine self-administration, extinction, and reinstatement. Behav Brain Res. 2013 Jan 01; 236(1):78-89. PMID: 22940018.
      View in: PubMed
    23. Mahler SV, Smith RJ, Aston-Jones G. Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl). 2013 Apr; 226(4):687-98. PMID: 22411428.
      View in: PubMed
    24. Mahler SV, Smith RJ, Moorman DE, Sartor GC, Aston-Jones G. Multiple roles for orexin/hypocretin in addiction. Prog Brain Res. 2012; 198:79-121. PMID: 22813971.
      View in: PubMed
    25. Mahler SV, Berridge KC. What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex. Psychopharmacology (Berl). 2012 Jun; 221(3):407-26. PMID: 22167254.
      View in: PubMed
    26. Mahler SV, de Wit H. Cue-reactors: individual differences in cue-induced craving after food or smoking abstinence. PLoS One. 2010 Nov 10; 5(11):e15475. PMID: 21085667.
      View in: PubMed
    27. Mahler SV, Berridge KC. Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue. J Neurosci. 2009 May 20; 29(20):6500-13. PMID: 19458221.
      View in: PubMed
    28. Mahler SV, Smith KS, Berridge KC. Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. Neuropsychopharmacology. 2007 Nov; 32(11):2267-78. PMID: 17406653.
      View in: PubMed
    29. Acheson A, Mahler SV, Chi H, de Wit H. Differential effects of nicotine on alcohol consumption in men and women. Psychopharmacology (Berl). 2006 May; 186(1):54-63. PMID: 16565827.
      View in: PubMed
    30. Alsene KM, Mahler SV, de Wit H. Effects of d-amphetamine and smoking abstinence on cue-induced cigarette craving. Exp Clin Psychopharmacol. 2005 Aug; 13(3):209-18. PMID: 16173884.
      View in: PubMed
    31. Mahler SV, de Wit H. Effects of haloperidol on reactions to smoking cues in humans. Behav Pharmacol. 2005 Mar; 16(2):123-6. PMID: 15767848.
      View in: PubMed
    32. Young EM, Mahler S, Chi H, de Wit H. Mecamylamine and ethanol preference in healthy volunteers. Alcohol Clin Exp Res. 2005 Jan; 29(1):58-65. PMID: 15654292.
      View in: PubMed
    33. Awad SS, Hemmila MR, Soldes OS, Sawada S, Rich PB, Mahler S, Gargulinski M, Hirschl RB, Bartlett RH. A novel stable reproducible model of hepatic failure in canines. J Surg Res. 2000 Dec; 94(2):167-71. PMID: 11104657.
      View in: PubMed