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John H Weiss

Title(s)Professor, Neurology
Phone(949) 824-6774, 8479
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    Mitochondrial Zn2+ accumulation and the induction of ischemic neurodegeneration
    NIH/NINDS R56NS100494Sep 15, 2018 - Sep 14, 2019
    Role: Principal Investigator
    Mitochondrial Zn2+ in ischemic neurodegeneration: In vivo tests of principle studies in a rat cardiac arrest model
    NIH/NINDS R21NS096987Jun 1, 2016 - May 31, 2018
    Role: Principal Investigator
    Zn2+, mitochondria and the induction of ischemic neurodegeneration
    NIH/NINDS R01NS065219Jan 15, 2010 - Dec 31, 2014
    Role: Principal Investigator
    AMPA/Kainate Receptors, Free Radicals, And Motor Neuron Injury
    NIH/NINDS R01NS036548Jun 1, 1999 - Dec 31, 2011
    Role: Principal Investigator
    ZN2+ AND CALCIUM PERMEABLE AMPA/KAINATE CHANNELS
    NIH/NIA K02AG000836Jun 1, 1998 - May 31, 2003
    Role: Principal Investigator
    CA2+, ZN2+ AND SELECTIVE EXCITOTOXIC NEURODEGENERATION
    NIH/NINDS R01NS030884Aug 1, 1992 - May 31, 2004
    Role: Principal Investigator
    CHRONIC NEUROTOXICITY OF BMAA AND NON-NMDA AGONISTS
    NIH/NIA K08AG000495Jul 1, 1990 - Jun 30, 1995
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yin HZ, Wang HL, Ji SG, Medvedeva YV, Tian G, Bazrafkan AK, Maki NZ, Akbari Y, Weiss JH. Rapid Intramitochondrial Zn2+ Accumulation in CA1 Hippocampal Pyramidal Neurons After Transient Global Ischemia: A Possible Contributor to Mitochondrial Disruption and Cell Death. J Neuropathol Exp Neurol. 2019 Jul 01; 78(7):655-664. PMID: 31150090.
      View in: PubMed
    2. Ji SG, Medvedeva YV, Wang HL, Yin HZ, Weiss JH. Mitochondrial Zn2+ Accumulation: A Potential Trigger of Hippocampal Ischemic Injury. Neuroscientist. 2019 04; 25(2):126-138. PMID: 29742958.
      View in: PubMed
    3. Ji SG, Weiss JH. Zn2+-induced disruption of neuronal mitochondrial function: Synergism with Ca2+, critical dependence upon cytosolic Zn2+ buffering, and contributions to neuronal injury. Exp Neurol. 2018 04; 302:181-195. PMID: 29355498.
      View in: PubMed
    4. Medvedeva YV, Ji SG, Yin HZ, Weiss JH. Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria. J Neurosci. 2017 01 18; 37(3):726-737. PMID: 28100752.
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    5. Li SC, Kabeer MH, Vu LT, Keschrumrus V, Yin HZ, Dethlefs BA, Zhong JF, Weiss JH, Loudon WG. Training stem cells for treatment of malignant brain tumors. World J Stem Cells. 2014 Sep 26; 6(4):432-40. PMID: 25258664.
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    6. Yin HZ, Yu S, Hsu CI, Liu J, Acab A, Wu R, Tao A, Chiang BJ, Weiss JH. Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord. Exp Neurol. 2014 Nov; 261:1-9. PMID: 24918341.
      View in: PubMed
    7. Medvedeva YV, Weiss JH. Intramitochondrial Zn2+ accumulation via the Ca2+ uniporter contributes to acute ischemic neurodegeneration. Neurobiol Dis. 2014 Aug; 68:137-44. PMID: 24787898.
      View in: PubMed
    8. Clausen A, McClanahan T, Ji SG, Weiss JH. Mechanisms of rapid reactive oxygen species generation in response to cytosolic Ca2+ or Zn2+ loads in cortical neurons. PLoS One. 2013; 8(12):e83347. PMID: 24340096.
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    9. Li SC, Yin HZ, Loudon WG, Weiss JH. Cultivating stem cells for treating amyotrophic lateral sclerosis. World J Stem Cells. 2012 Dec 26; 4(12):117-9. PMID: 23516096.
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    10. Nalbandian A, Llewellyn KJ, Badadani M, Yin HZ, Nguyen C, Katheria V, Watts G, Mukherjee J, Vesa J, Caiozzo V, Mozaffar T, Weiss JH, Kimonis VE. A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse. Muscle Nerve. 2013 Feb; 47(2):260-70. PMID: 23169451.
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    11. Nalbandian A, Llewellyn KJ, Kitazawa M, Yin HZ, Badadani M, Khanlou N, Edwards R, Nguyen C, Mukherjee J, Mozaffar T, Watts G, Weiss J, Kimonis VE. The homozygote VCP(R¹55H/R¹55H) mouse model exhibits accelerated human VCP-associated disease pathology. PLoS One. 2012; 7(9):e46308. PMID: 23029473.
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    12. Li SC, Vu LT, Ho HW, Yin HZ, Keschrumrus V, Lu Q, Wang J, Zhang H, Ma Z, Stover A, Weiss JH, Schwartz PH, Loudon WG. Cancer stem cells from a rare form of glioblastoma multiforme involving the neurogenic ventricular wall. Cancer Cell Int. 2012 Sep 20; 12(1):41. PMID: 22995409.
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    13. Yin HZ, Hsu CI, Yu S, Rao SD, Sorkin LS, Weiss JH. TNF-a triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury. Exp Neurol. 2012 Dec; 238(2):93-102. PMID: 22921461.
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    14. Guo J, Duckles SP, Weiss JH, Li X, Krause DN. 17ß-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion. Free Radic Biol Med. 2012 Jun 1-15; 52(11-12):2151-60. PMID: 22554613.
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    15. Yin HZ, Weiss JH. Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures. Brain Res. 2012 Apr 11; 1448:153-62. PMID: 22370146.
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    16. Weiss JH. Ca permeable AMPA channels in diseases of the nervous system. Front Mol Neurosci. 2011; 4:42. PMID: 22102834.
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    17. Shuttleworth CW, Weiss JH. Zinc: new clues to diverse roles in brain ischemia. Trends Pharmacol Sci. 2011 Aug; 32(8):480-6. PMID: 21621864.
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    18. Mei Y, Frederickson CJ, Giblin LJ, Weiss JH, Medvedeva Y, Bentley PA. Sensitive and selective detection of zinc ions in neuronal vesicles using PYDPY1, a simple turn-on dipyrrin. Chem Commun (Camb). 2011 Jul 07; 47(25):7107-9. PMID: 21614400.
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    19. Carter RE, Weiss JH, Shuttleworth CW. Zn²+ chelation improves recovery by delaying spreading depression-like events. Neuroreport. 2010 Nov 17; 21(16):1060-4. PMID: 20856149.
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    20. Rossi SL, Nistor G, Wyatt T, Yin HZ, Poole AJ, Weiss JH, Gardener MJ, Dijkstra S, Fischer DF, Keirstead HS. Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord. PLoS One. 2010 Jul 29; 5(7):e11852. PMID: 20686613.
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    21. Guo J, Krause DN, Horne J, Weiss JH, Li X, Duckles SP. Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro. J Cereb Blood Flow Metab. 2010 Mar; 30(3):545-54. PMID: 19861973.
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    22. Su H, Fan W, Coskun PE, Vesa J, Gold JA, Jiang YH, Potluri P, Procaccio V, Acab A, Weiss JH, Wallace DC, Kimonis VE. Mitochondrial dysfunction in CA1 hippocampal neurons of the UBE3A deficient mouse model for Angelman syndrome. Neurosci Lett. 2011 Jan 07; 487(2):129-33. PMID: 19563863.
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    23. Dietz RM, Weiss JH, Shuttleworth CW. Contributions of Ca2+ and Zn2+ to spreading depression-like events and neuronal injury. J Neurochem. 2009 May; 109 Suppl 1:145-52. PMID: 19393021.
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    24. Medvedeva YV, Lin B, Shuttleworth CW, Weiss JH. Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia. J Neurosci. 2009 Jan 28; 29(4):1105-14. PMID: 19176819.
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    25. Vyas KJ, Weiss JH. BMAA--an unusual cyanobacterial neurotoxin. Amyotroph Lateral Scler. 2009; 10 Suppl 2:50-5. PMID: 19929732.
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    26. Dietz RM, Weiss JH, Shuttleworth CW. Zn2+ influx is critical for some forms of spreading depression in brain slices. J Neurosci. 2008 Aug 06; 28(32):8014-24. PMID: 18685026.
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    27. Richichi C, Brewster AL, Bender RA, Simeone TA, Zha Q, Yin HZ, Weiss JH, Baram TZ. Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiol Dis. 2008 Feb; 29(2):297-305. PMID: 17964174.
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    28. Yin HZ, Tang DT, Weiss JH. Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS. Exp Neurol. 2007 Oct; 207(2):177-85. PMID: 17719032.
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    29. Rao SD, Banack SA, Cox PA, Weiss JH. BMAA selectively injures motor neurons via AMPA/kainate receptor activation. Exp Neurol. 2006 Sep; 201(1):244-52. PMID: 16764863.
      View in: PubMed
    30. Kwak S, Weiss JH. Calcium-permeable AMPA channels in neurodegenerative disease and ischemia. Curr Opin Neurobiol. 2006 Jun; 16(3):281-7. PMID: 16698262.
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    31. Ogoshi F, Yin HZ, Kuppumbatti Y, Song B, Amindari S, Weiss JH. Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons. Exp Neurol. 2005 Jun; 193(2):384-93. PMID: 15869941.
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    32. Frederickson CJ, Burdette SC, Frederickson CJ, Sensi SL, Weiss JH, Yin HZ, Balaji RV, Truong-Tran AQ, Bedell E, Prough DS, Lippard SJ. Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor. J Neurosci Methods. 2004 Oct 15; 139(1):79-89. PMID: 15351524.
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    33. Rao SD, Weiss JH. Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis. Trends Neurosci. 2004 Jan; 27(1):17-23. PMID: 14698606.
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    34. Ogoshi F, Weiss JH. Heterogeneity of Ca2+-permeable AMPA/kainate channel expression in hippocampal pyramidal neurons: fluorescence imaging and immunocytochemical assessment. J Neurosci. 2003 Nov 19; 23(33):10521-30. PMID: 14627636.
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    35. Ketterer K, Rao S, Friess H, Weiss J, Büchler MW, Korc M. Reverse transcription-PCR analysis of laser-captured cells points to potential paracrine and autocrine actions of neurotrophins in pancreatic cancer. Clin Cancer Res. 2003 Nov 01; 9(14):5127-36. PMID: 14613990.
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    36. Ohana E, Segal D, Palty R, Ton-That D, Moran A, Sensi SL, Weiss JH, Hershfinkel M, Sekler I. A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells. J Biol Chem. 2004 Feb 06; 279(6):4278-84. PMID: 14581475.
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    37. Sensi SL, Ton-That D, Weiss JH, Rothe A, Gee KR. A new mitochondrial fluorescent zinc sensor. Cell Calcium. 2003 Sep; 34(3):281-4. PMID: 12887975.
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    38. Sensi SL, Ton-That D, Sullivan PG, Jonas EA, Gee KR, Kaczmarek LK, Weiss JH. Modulation of mitochondrial function by endogenous Zn2+ pools. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):6157-62. PMID: 12724524.
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    39. Rao SD, Yin HZ, Weiss JH. Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons. J Neurosci. 2003 Apr 01; 23(7):2627-33. PMID: 12684448.
      View in: PubMed
    40. Jia Y, Jeng JM, Sensi SL, Weiss JH. Zn2+ currents are mediated by calcium-permeable AMPA/kainate channels in cultured murine hippocampal neurones. J Physiol. 2002 Aug 15; 543(Pt 1):35-48. PMID: 12181280.
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    41. Sensi SL, Ton-That D, Weiss JH. Mitochondrial sequestration and Ca(2+)-dependent release of cytosolic Zn(2+) loads in cortical neurons. Neurobiol Dis. 2002 Jul; 10(2):100-8. PMID: 12127148.
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    42. Yin HZ, Sensi SL, Ogoshi F, Weiss JH. Blockade of Ca2+-permeable AMPA/kainate channels decreases oxygen-glucose deprivation-induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons. J Neurosci. 2002 Feb 15; 22(4):1273-9. PMID: 11850455.
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    43. Weiss JH, Sensi SL, Koh JY. Zn(2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci. 2000 Oct; 21(10):395-401. PMID: 11050320.
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