John H Weiss

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6774, 8479
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    Collapse Research 
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    Mitochondrial Zn2+ accumulation and the induction of ischemic neurodegeneration
    NIH R56NS100494Sep 15, 2018 - Sep 14, 2021
    Role: Principal Investigator
    Mitochondrial Zn2+ in ischemic neurodegeneration: In vivo tests of principle studies in a rat cardiac arrest model
    NIH R21NS096987Jun 1, 2016 - May 31, 2019
    Role: Principal Investigator
    Zn2+, mitochondria and the induction of ischemic neurodegeneration
    NIH R01NS065219Jan 15, 2010 - Dec 31, 2015
    Role: Principal Investigator
    AMPA/Kainate Receptors, Free Radicals, And Motor Neuron Injury
    NIH R01NS036548Jun 1, 1999 - Dec 31, 2011
    Role: Principal Investigator
    ZN2+ AND CALCIUM PERMEABLE AMPA/KAINATE CHANNELS
    NIH K02AG000836Jun 1, 1998 - May 31, 2003
    Role: Principal Investigator
    CA2+, ZN2+ AND SELECTIVE EXCITOTOXIC NEURODEGENERATION
    NIH R01NS030884Aug 1, 1992 - May 31, 2004
    Role: Principal Investigator
    CHRONIC NEUROTOXICITY OF BMAA AND NON-NMDA AGONISTS
    NIH K08AG000495Jul 1, 1990 - Jun 30, 1995
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Blocking mitochondrial Zn2+ accumulation after ischemia reduces mitochondrial dysfunction and neuronal injury. J Neurosci. 2022 May 27. Medvedeva YV, Yin HZ, Bazrafkan A, Yeromin A, Ji SG, Weiss-Hung EJ, Sharman E, Avilez AP, Maki N, Rafi MA, Tian G, Akbari Y, Weiss JH. PMID: 35623885; PMCID: PMC9236293.
      View in: PubMed   Mentions:    Fields:    
    2. Editorial: Excitotoxicity Turns 50. The Death That Never Dies. Front Neurosci. 2021; 15:831809. Granzotto A, Weiss JH, Sensi SL. PMID: 35110994; PMCID: PMC8801869.
      View in: PubMed   Mentions: 3  
    3. The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction. Biomedicines. 2021 Apr 29; 9(5). Liu HY, Gale JR, Reynolds IJ, Weiss JH, Aizenman E. PMID: 33946782; PMCID: PMC8145363.
      View in: PubMed   Mentions: 8  
    4. Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration. Exp Neurol. 2020 03; 325:113161. Ji SG, Medvedeva YV, Weiss JH. PMID: 31881218; PMCID: PMC6957126.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    5. Rapid Intramitochondrial Zn2+ Accumulation in CA1 Hippocampal Pyramidal Neurons After Transient Global Ischemia: A Possible Contributor to Mitochondrial Disruption and Cell Death. J Neuropathol Exp Neurol. 2019 07 01; 78(7):655-664. Yin HZ, Wang HL, Ji SG, Medvedeva YV, Tian G, Bazrafkan AK, Maki NZ, Akbari Y, Weiss JH. PMID: 31150090; PMCID: PMC6581555.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    6. Mitochondrial Zn2+ Accumulation: A Potential Trigger of Hippocampal Ischemic Injury. Neuroscientist. 2019 04; 25(2):126-138. Ji SG, Medvedeva YV, Wang HL, Yin HZ, Weiss JH. PMID: 29742958; PMCID: PMC6730558.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    7. Zn2+-induced disruption of neuronal mitochondrial function: Synergism with Ca2+, critical dependence upon cytosolic Zn2+ buffering, and contributions to neuronal injury. Exp Neurol. 2018 04; 302:181-195. Ji SG, Weiss JH. PMID: 29355498; PMCID: PMC5849513.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    8. Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria. J Neurosci. 2017 01 18; 37(3):726-737. Medvedeva YV, Ji SG, Yin HZ, Weiss JH. PMID: 28100752; PMCID: PMC5242414.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    9. Training stem cells for treatment of malignant brain tumors. World J Stem Cells. 2014 Sep 26; 6(4):432-40. Li SC, Kabeer MH, Vu LT, Keschrumrus V, Yin HZ, Dethlefs BA, Zhong JF, Weiss JH, Loudon WG. PMID: 25258664; PMCID: PMC4172671.
      View in: PubMed   Mentions: 4  
    10. Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord. Exp Neurol. 2014 Nov; 261:1-9. Yin HZ, Yu S, Hsu CI, Liu J, Acab A, Wu R, Tao A, Chiang BJ, Weiss JH. PMID: 24918341; PMCID: PMC4194249.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    11. Intramitochondrial Zn2+ accumulation via the Ca2+ uniporter contributes to acute ischemic neurodegeneration. Neurobiol Dis. 2014 Aug; 68:137-44. Medvedeva YV, Weiss JH. PMID: 24787898; PMCID: PMC4065779.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    12. Mechanisms of rapid reactive oxygen species generation in response to cytosolic Ca2+ or Zn2+ loads in cortical neurons. PLoS One. 2013; 8(12):e83347. Clausen A, McClanahan T, Ji SG, Weiss JH. PMID: 24340096; PMCID: PMC3858366.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    13. Cultivating stem cells for treating amyotrophic lateral sclerosis. World J Stem Cells. 2012 Dec 26; 4(12):117-9. Li SC, Yin HZ, Loudon WG, Weiss JH. PMID: 23516096; PMCID: PMC3600561.
      View in: PubMed   Mentions:
    14. A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse. Muscle Nerve. 2013 Feb; 47(2):260-70. Nalbandian A, Llewellyn KJ, Badadani M, Yin HZ, Nguyen C, Katheria V, Watts G, Mukherjee J, Vesa J, Caiozzo V, Mozaffar T, Weiss JH, Kimonis VE. PMID: 23169451; PMCID: PMC3556223.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    15. The homozygote VCP(R¹⁵⁵H/R¹⁵⁵H) mouse model exhibits accelerated human VCP-associated disease pathology. PLoS One. 2012; 7(9):e46308. Nalbandian A, Llewellyn KJ, Kitazawa M, Yin HZ, Badadani M, Khanlou N, Edwards R, Nguyen C, Mukherjee J, Mozaffar T, Watts G, Weiss J, Kimonis VE. PMID: 23029473; PMCID: PMC3460820.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    16. Cancer stem cells from a rare form of glioblastoma multiforme involving the neurogenic ventricular wall. Cancer Cell Int. 2012 Sep 20; 12(1):41. Li SC, Vu LT, Ho HW, Yin HZ, Keschrumrus V, Lu Q, Wang J, Zhang H, Ma Z, Stover A, Weiss JH, Schwartz PH, Loudon WG. PMID: 22995409; PMCID: PMC3546918.
      View in: PubMed   Mentions: 11  
    17. TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury. Exp Neurol. 2012 Dec; 238(2):93-102. Yin HZ, Hsu CI, Yu S, Rao SD, Sorkin LS, Weiss JH. PMID: 22921461; PMCID: PMC3498614.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    18. 17β-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion. Free Radic Biol Med. 2012 Jun 1-15; 52(11-12):2151-60. Guo J, Duckles SP, Weiss JH, Li X, Krause DN. PMID: 22554613; PMCID: PMC3377773.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    19. Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures. Brain Res. 2012 Apr 11; 1448:153-62. Yin HZ, Weiss JH. PMID: 22370146; PMCID: PMC3309159.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    20. Ca permeable AMPA channels in diseases of the nervous system. Front Mol Neurosci. 2011; 4:42. Weiss JH. PMID: 22102834; PMCID: PMC3214733.
      View in: PubMed   Mentions: 43  
    21. Zinc: new clues to diverse roles in brain ischemia. Trends Pharmacol Sci. 2011 Aug; 32(8):480-6. Shuttleworth CW, Weiss JH. PMID: 21621864; PMCID: PMC3148334.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    22. Sensitive and selective detection of zinc ions in neuronal vesicles using PYDPY1, a simple turn-on dipyrrin. Chem Commun (Camb). 2011 Jul 07; 47(25):7107-9. Mei Y, Frederickson CJ, Giblin LJ, Weiss JH, Medvedeva Y, Bentley PA. PMID: 21614400.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Zn²+ chelation improves recovery by delaying spreading depression-like events. Neuroreport. 2010 Nov 17; 21(16):1060-4. Carter RE, Weiss JH, Shuttleworth CW. PMID: 20856149; PMCID: PMC3092444.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    24. Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord. PLoS One. 2010 Jul 29; 5(7):e11852. Rossi SL, Nistor G, Wyatt T, Yin HZ, Poole AJ, Weiss JH, Gardener MJ, Dijkstra S, Fischer DF, Keirstead HS. PMID: 20686613; PMCID: PMC2912300.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    25. Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro. J Cereb Blood Flow Metab. 2010 Mar; 30(3):545-54. Guo J, Krause DN, Horne J, Weiss JH, Li X, Duckles SP. PMID: 19861973; PMCID: PMC2831126.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    26. Mitochondrial dysfunction in CA1 hippocampal neurons of the UBE3A deficient mouse model for Angelman syndrome. Neurosci Lett. 2011 Jan 07; 487(2):129-33. Su H, Fan W, Coskun PE, Vesa J, Gold JA, Jiang YH, Potluri P, Procaccio V, Acab A, Weiss JH, Wallace DC, Kimonis VE. PMID: 19563863; PMCID: PMC2888840.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    27. Contributions of Ca2+ and Zn2+ to spreading depression-like events and neuronal injury. J Neurochem. 2009 May; 109 Suppl 1:145-52. Dietz RM, Weiss JH, Shuttleworth CW. PMID: 19393021; PMCID: PMC2692040.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    28. Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia. J Neurosci. 2009 Jan 28; 29(4):1105-14. Medvedeva YV, Lin B, Shuttleworth CW, Weiss JH. PMID: 19176819; PMCID: PMC2637403.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    29. BMAA--an unusual cyanobacterial neurotoxin. Amyotroph Lateral Scler. 2009; 10 Suppl 2:50-5. Vyas KJ, Weiss JH. PMID: 19929732.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    30. Zn2+ influx is critical for some forms of spreading depression in brain slices. J Neurosci. 2008 Aug 06; 28(32):8014-24. Dietz RM, Weiss JH, Shuttleworth CW. PMID: 18685026; PMCID: PMC2577031.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    31. Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiol Dis. 2008 Feb; 29(2):297-305. Richichi C, Brewster AL, Bender RA, Simeone TA, Zha Q, Yin HZ, Weiss JH, Baram TZ. PMID: 17964174; PMCID: PMC2292123.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    32. Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS. Exp Neurol. 2007 Oct; 207(2):177-85. Yin HZ, Tang DT, Weiss JH. PMID: 17719032; PMCID: PMC2083564.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    33. BMAA selectively injures motor neurons via AMPA/kainate receptor activation. Exp Neurol. 2006 Sep; 201(1):244-52. Rao SD, Banack SA, Cox PA, Weiss JH. PMID: 16764863.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    34. Calcium-permeable AMPA channels in neurodegenerative disease and ischemia. Curr Opin Neurobiol. 2006 Jun; 16(3):281-7. Kwak S, Weiss JH. PMID: 16698262.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    35. Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons. Exp Neurol. 2005 Jun; 193(2):384-93. Ogoshi F, Yin HZ, Kuppumbatti Y, Song B, Amindari S, Weiss JH. PMID: 15869941.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    36. Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor. J Neurosci Methods. 2004 Oct 15; 139(1):79-89. Frederickson CJ, Burdette SC, Frederickson CJ, Sensi SL, Weiss JH, Yin HZ, Balaji RV, Truong-Tran AQ, Bedell E, Prough DS, Lippard SJ. PMID: 15351524.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    37. Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis. Trends Neurosci. 2004 Jan; 27(1):17-23. Rao SD, Weiss JH. PMID: 14698606.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    38. Heterogeneity of Ca2+-permeable AMPA/kainate channel expression in hippocampal pyramidal neurons: fluorescence imaging and immunocytochemical assessment. J Neurosci. 2003 Nov 19; 23(33):10521-30. Ogoshi F, Weiss JH. PMID: 14627636; PMCID: PMC6740912.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    39. Reverse transcription-PCR analysis of laser-captured cells points to potential paracrine and autocrine actions of neurotrophins in pancreatic cancer. Clin Cancer Res. 2003 Nov 01; 9(14):5127-36. Ketterer K, Rao S, Friess H, Weiss J, Büchler MW, Korc M. PMID: 14613990.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    40. A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells. J Biol Chem. 2004 Feb 06; 279(6):4278-84. Ohana E, Segal D, Palty R, Ton-That D, Moran A, Sensi SL, Weiss JH, Hershfinkel M, Sekler I. PMID: 14581475.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    41. A new mitochondrial fluorescent zinc sensor. Cell Calcium. 2003 Sep; 34(3):281-4. Sensi SL, Ton-That D, Weiss JH, Rothe A, Gee KR. PMID: 12887975.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    42. Modulation of mitochondrial function by endogenous Zn2+ pools. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):6157-62. Sensi SL, Ton-That D, Sullivan PG, Jonas EA, Gee KR, Kaczmarek LK, Weiss JH. PMID: 12724524; PMCID: PMC156342.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    43. Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons. J Neurosci. 2003 Apr 01; 23(7):2627-33. Rao SD, Yin HZ, Weiss JH. PMID: 12684448; PMCID: PMC6742077.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    44. Mitochondrial sequestration and Ca(2+)-dependent release of cytosolic Zn(2+) loads in cortical neurons. Neurobiol Dis. 2002 Jul; 10(2):100-8. Sensi SL, Ton-That D, Weiss JH. PMID: 12127148.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    45. Zn(2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci. 2000 Oct; 21(10):395-401. Weiss JH, Sensi SL, Koh JY. PMID: 11050320.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
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