John H Weiss

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6774, 8479
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    Mitochondrial Zn2+ accumulation and the induction of ischemic neurodegeneration
    NIH R56NS100494Sep 15, 2018 - Sep 14, 2021
    Role: Principal Investigator
    Mitochondrial Zn2+ in ischemic neurodegeneration: In vivo tests of principle studies in a rat cardiac arrest model
    NIH R21NS096987Jun 1, 2016 - May 31, 2019
    Role: Principal Investigator
    Zn2+, mitochondria and the induction of ischemic neurodegeneration
    NIH R01NS065219Jan 15, 2010 - Dec 31, 2015
    Role: Principal Investigator
    AMPA/Kainate Receptors, Free Radicals, And Motor Neuron Injury
    NIH R01NS036548Jun 1, 1999 - Dec 31, 2011
    Role: Principal Investigator
    ZN2+ AND CALCIUM PERMEABLE AMPA/KAINATE CHANNELS
    NIH K02AG000836Jun 1, 1998 - May 31, 2003
    Role: Principal Investigator
    CA2+, ZN2+ AND SELECTIVE EXCITOTOXIC NEURODEGENERATION
    NIH R01NS030884Aug 1, 1992 - May 31, 2004
    Role: Principal Investigator
    CHRONIC NEUROTOXICITY OF BMAA AND NON-NMDA AGONISTS
    NIH K08AG000495Jul 1, 1990 - Jun 30, 1995
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Editorial: Excitotoxicity Turns 50. The Death That Never Dies. Front Neurosci. 2021; 15:831809. Granzotto A, Weiss JH, Sensi SL. PMID: 35110994; PMCID: PMC8801869.
      View in: PubMed   Mentions:
    2. The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction. Biomedicines. 2021 Apr 29; 9(5). Liu HY, Gale JR, Reynolds IJ, Weiss JH, Aizenman E. PMID: 33946782; PMCID: PMC8145363.
      View in: PubMed   Mentions: 1  
    3. Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration. Exp Neurol. 2020 03; 325:113161. Ji SG, Medvedeva YV, Weiss JH. PMID: 31881218; PMCID: PMC6957126.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    4. Rapid Intramitochondrial Zn2+ Accumulation in CA1 Hippocampal Pyramidal Neurons After Transient Global Ischemia: A Possible Contributor to Mitochondrial Disruption and Cell Death. J Neuropathol Exp Neurol. 2019 07 01; 78(7):655-664. Yin HZ, Wang HL, Ji SG, Medvedeva YV, Tian G, Bazrafkan AK, Maki NZ, Akbari Y, Weiss JH. PMID: 31150090; PMCID: PMC6581555.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    5. Mitochondrial Zn2+ Accumulation: A Potential Trigger of Hippocampal Ischemic Injury. Neuroscientist. 2019 04; 25(2):126-138. Ji SG, Medvedeva YV, Wang HL, Yin HZ, Weiss JH. PMID: 29742958; PMCID: PMC6730558.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    6. Zn2+-induced disruption of neuronal mitochondrial function: Synergism with Ca2+, critical dependence upon cytosolic Zn2+ buffering, and contributions to neuronal injury. Exp Neurol. 2018 04; 302:181-195. Ji SG, Weiss JH. PMID: 29355498; PMCID: PMC5849513.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria. J Neurosci. 2017 01 18; 37(3):726-737. Medvedeva YV, Ji SG, Yin HZ, Weiss JH. PMID: 28100752; PMCID: PMC5242414.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    8. Training stem cells for treatment of malignant brain tumors. World J Stem Cells. 2014 Sep 26; 6(4):432-40. Li SC, Kabeer MH, Vu LT, Keschrumrus V, Yin HZ, Dethlefs BA, Zhong JF, Weiss JH, Loudon WG. PMID: 25258664; PMCID: PMC4172671.
      View in: PubMed   Mentions: 4  
    9. Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord. Exp Neurol. 2014 Nov; 261:1-9. Yin HZ, Yu S, Hsu CI, Liu J, Acab A, Wu R, Tao A, Chiang BJ, Weiss JH. PMID: 24918341; PMCID: PMC4194249.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    10. Intramitochondrial Zn2+ accumulation via the Ca2+ uniporter contributes to acute ischemic neurodegeneration. Neurobiol Dis. 2014 Aug; 68:137-44. Medvedeva YV, Weiss JH. PMID: 24787898; PMCID: PMC4065779.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    11. Mechanisms of rapid reactive oxygen species generation in response to cytosolic Ca2+ or Zn2+ loads in cortical neurons. PLoS One. 2013; 8(12):e83347. Clausen A, McClanahan T, Ji SG, Weiss JH. PMID: 24340096; PMCID: PMC3858366.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    12. Cultivating stem cells for treating amyotrophic lateral sclerosis. World J Stem Cells. 2012 Dec 26; 4(12):117-9. Li SC, Yin HZ, Loudon WG, Weiss JH. PMID: 23516096; PMCID: PMC3600561.
      View in: PubMed   Mentions:
    13. A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse. Muscle Nerve. 2013 Feb; 47(2):260-70. Nalbandian A, Llewellyn KJ, Badadani M, Yin HZ, Nguyen C, Katheria V, Watts G, Mukherjee J, Vesa J, Caiozzo V, Mozaffar T, Weiss JH, Kimonis VE. PMID: 23169451; PMCID: PMC3556223.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    14. The homozygote VCP(R¹⁵⁵H/R¹⁵⁵H) mouse model exhibits accelerated human VCP-associated disease pathology. PLoS One. 2012; 7(9):e46308. Nalbandian A, Llewellyn KJ, Kitazawa M, Yin HZ, Badadani M, Khanlou N, Edwards R, Nguyen C, Mukherjee J, Mozaffar T, Watts G, Weiss J, Kimonis VE. PMID: 23029473; PMCID: PMC3460820.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    15. Cancer stem cells from a rare form of glioblastoma multiforme involving the neurogenic ventricular wall. Cancer Cell Int. 2012 Sep 20; 12(1):41. Li SC, Vu LT, Ho HW, Yin HZ, Keschrumrus V, Lu Q, Wang J, Zhang H, Ma Z, Stover A, Weiss JH, Schwartz PH, Loudon WG. PMID: 22995409; PMCID: PMC3546918.
      View in: PubMed   Mentions: 9  
    16. TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury. Exp Neurol. 2012 Dec; 238(2):93-102. Yin HZ, Hsu CI, Yu S, Rao SD, Sorkin LS, Weiss JH. PMID: 22921461; PMCID: PMC3498614.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    17. 17β-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion. Free Radic Biol Med. 2012 Jun 1-15; 52(11-12):2151-60. Guo J, Duckles SP, Weiss JH, Li X, Krause DN. PMID: 22554613; PMCID: PMC3377773.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    18. Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures. Brain Res. 2012 Apr 11; 1448:153-62. Yin HZ, Weiss JH. PMID: 22370146; PMCID: PMC3309159.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    19. Ca permeable AMPA channels in diseases of the nervous system. Front Mol Neurosci. 2011; 4:42. Weiss JH. PMID: 22102834; PMCID: PMC3214733.
      View in: PubMed   Mentions: 33  
    20. Zinc: new clues to diverse roles in brain ischemia. Trends Pharmacol Sci. 2011 Aug; 32(8):480-6. Shuttleworth CW, Weiss JH. PMID: 21621864; PMCID: PMC3148334.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    21. Sensitive and selective detection of zinc ions in neuronal vesicles using PYDPY1, a simple turn-on dipyrrin. Chem Commun (Camb). 2011 Jul 07; 47(25):7107-9. Mei Y, Frederickson CJ, Giblin LJ, Weiss JH, Medvedeva Y, Bentley PA. PMID: 21614400.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Zn²+ chelation improves recovery by delaying spreading depression-like events. Neuroreport. 2010 Nov 17; 21(16):1060-4. Carter RE, Weiss JH, Shuttleworth CW. PMID: 20856149; PMCID: PMC3092444.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    23. Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord. PLoS One. 2010 Jul 29; 5(7):e11852. Rossi SL, Nistor G, Wyatt T, Yin HZ, Poole AJ, Weiss JH, Gardener MJ, Dijkstra S, Fischer DF, Keirstead HS. PMID: 20686613; PMCID: PMC2912300.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    24. Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro. J Cereb Blood Flow Metab. 2010 Mar; 30(3):545-54. Guo J, Krause DN, Horne J, Weiss JH, Li X, Duckles SP. PMID: 19861973; PMCID: PMC2831126.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    25. Mitochondrial dysfunction in CA1 hippocampal neurons of the UBE3A deficient mouse model for Angelman syndrome. Neurosci Lett. 2011 Jan 07; 487(2):129-33. Su H, Fan W, Coskun PE, Vesa J, Gold JA, Jiang YH, Potluri P, Procaccio V, Acab A, Weiss JH, Wallace DC, Kimonis VE. PMID: 19563863; PMCID: PMC2888840.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    26. Contributions of Ca2+ and Zn2+ to spreading depression-like events and neuronal injury. J Neurochem. 2009 May; 109 Suppl 1:145-52. Dietz RM, Weiss JH, Shuttleworth CW. PMID: 19393021; PMCID: PMC2692040.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    27. Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia. J Neurosci. 2009 Jan 28; 29(4):1105-14. Medvedeva YV, Lin B, Shuttleworth CW, Weiss JH. PMID: 19176819; PMCID: PMC2637403.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    28. BMAA--an unusual cyanobacterial neurotoxin. Amyotroph Lateral Scler. 2009; 10 Suppl 2:50-5. Vyas KJ, Weiss JH. PMID: 19929732.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    29. Zn2+ influx is critical for some forms of spreading depression in brain slices. J Neurosci. 2008 Aug 06; 28(32):8014-24. Dietz RM, Weiss JH, Shuttleworth CW. PMID: 18685026; PMCID: PMC2577031.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    30. Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiol Dis. 2008 Feb; 29(2):297-305. Richichi C, Brewster AL, Bender RA, Simeone TA, Zha Q, Yin HZ, Weiss JH, Baram TZ. PMID: 17964174; PMCID: PMC2292123.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    31. Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS. Exp Neurol. 2007 Oct; 207(2):177-85. Yin HZ, Tang DT, Weiss JH. PMID: 17719032; PMCID: PMC2083564.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    32. BMAA selectively injures motor neurons via AMPA/kainate receptor activation. Exp Neurol. 2006 Sep; 201(1):244-52. Rao SD, Banack SA, Cox PA, Weiss JH. PMID: 16764863.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    33. Calcium-permeable AMPA channels in neurodegenerative disease and ischemia. Curr Opin Neurobiol. 2006 Jun; 16(3):281-7. Kwak S, Weiss JH. PMID: 16698262.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    34. Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons. Exp Neurol. 2005 Jun; 193(2):384-93. Ogoshi F, Yin HZ, Kuppumbatti Y, Song B, Amindari S, Weiss JH. PMID: 15869941.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    35. Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor. J Neurosci Methods. 2004 Oct 15; 139(1):79-89. Frederickson CJ, Burdette SC, Frederickson CJ, Sensi SL, Weiss JH, Yin HZ, Balaji RV, Truong-Tran AQ, Bedell E, Prough DS, Lippard SJ. PMID: 15351524.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    36. Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis. Trends Neurosci. 2004 Jan; 27(1):17-23. Rao SD, Weiss JH. PMID: 14698606.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    37. Heterogeneity of Ca2+-permeable AMPA/kainate channel expression in hippocampal pyramidal neurons: fluorescence imaging and immunocytochemical assessment. J Neurosci. 2003 Nov 19; 23(33):10521-30. Ogoshi F, Weiss JH. PMID: 14627636; PMCID: PMC6740912.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    38. Reverse transcription-PCR analysis of laser-captured cells points to potential paracrine and autocrine actions of neurotrophins in pancreatic cancer. Clin Cancer Res. 2003 Nov 01; 9(14):5127-36. Ketterer K, Rao S, Friess H, Weiss J, Büchler MW, Korc M. PMID: 14613990.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    39. A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells. J Biol Chem. 2004 Feb 06; 279(6):4278-84. Ohana E, Segal D, Palty R, Ton-That D, Moran A, Sensi SL, Weiss JH, Hershfinkel M, Sekler I. PMID: 14581475.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    40. A new mitochondrial fluorescent zinc sensor. Cell Calcium. 2003 Sep; 34(3):281-4. Sensi SL, Ton-That D, Weiss JH, Rothe A, Gee KR. PMID: 12887975.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    41. Modulation of mitochondrial function by endogenous Zn2+ pools. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):6157-62. Sensi SL, Ton-That D, Sullivan PG, Jonas EA, Gee KR, Kaczmarek LK, Weiss JH. PMID: 12724524; PMCID: PMC156342.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    42. Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons. J Neurosci. 2003 Apr 01; 23(7):2627-33. Rao SD, Yin HZ, Weiss JH. PMID: 12684448; PMCID: PMC6742077.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    43. Zn2+ currents are mediated by calcium-permeable AMPA/kainate channels in cultured murine hippocampal neurones. J Physiol. 2002 Aug 15; 543(Pt 1):35-48. Jia Y, Jeng JM, Sensi SL, Weiss JH. PMID: 12181280; PMCID: PMC2290471.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    44. Mitochondrial sequestration and Ca(2+)-dependent release of cytosolic Zn(2+) loads in cortical neurons. Neurobiol Dis. 2002 Jul; 10(2):100-8. Sensi SL, Ton-That D, Weiss JH. PMID: 12127148.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    45. Blockade of Ca2+-permeable AMPA/kainate channels decreases oxygen-glucose deprivation-induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons. J Neurosci. 2002 Feb 15; 22(4):1273-9. Yin HZ, Sensi SL, Ogoshi F, Weiss JH. PMID: 11850455; PMCID: PMC6757569.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    46. Zn(2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci. 2000 Oct; 21(10):395-401. Weiss JH, Sensi SL, Koh JY. PMID: 11050320.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
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