Naomi Morrissette

Title(s)Associate Professor, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
Address3213 McGaugh Hall
Zot 3900
Irvine CA 92697
Phone(949) 824-9243, 2805
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Dinitroaniline Action, Selectivity and Resistance
    NIH R01AI067981Jan 1, 2006 - Dec 31, 2012
    Role: Principal Investigator
    Dinitroaniline Specificity for Tubulin
    NIH K22AI055790Jul 1, 2004 - Jun 30, 2006
    Role: Principal Investigator
    Toxoplasma and Plasmodium resistance to dinitroanilines
    NIH F32GM020484May 1, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Toxoplasma replication is inhibited by MMV676477 without development of resistance. Cytoskeleton (Hoboken). 2024 May 16. Abbaali I, Truong D, Wetzel DM, Morrissette NS. PMID: 38757481.
      View in: PubMed   Mentions:    Fields:    
    2. The tubulin database: Linking mutations, modifications, ligands and local interactions. PLoS One. 2023; 18(12):e0295279. Abbaali I, Truong D, Day SD, Mushayeed F, Ganesh B, Haro-Ramirez N, Isles J, Nag H, Pham C, Shah P, Tomar I, Manel-Romero C, Morrissette NS. PMID: 38064432; PMCID: PMC10707541.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. The Tubulin Superfamily in Apicomplexan Parasites. Microorganisms. 2023 Mar 09; 11(3). Morrissette N, Abbaali I, Ramakrishnan C, Hehl AB. PMID: 36985278; PMCID: PMC10056924.
      View in: PubMed   Mentions: 3  
    4. Systematic Analysis of Clemastine, a Candidate Apicomplexan Parasite-Selective Tubulin-Targeting Agent. Int J Mol Sci. 2021 Dec 22; 23(1). Abbaali I, Truong DA, Day SD, Haro-Ramirez N, Morrissette NS. PMID: 35008492; PMCID: PMC8744746.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. EMBO Mol Med. 2021 11 08; 13(11):e13818. Gaillard N, Sharma A, Abbaali I, Liu T, Shilliday F, Cook AD, Ehrhard V, Bangera M, Roberts AJ, Moores CA, Morrissette N, Steinmetz MO. PMID: 34661376; PMCID: PMC8573600.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    6. Auranofin Resistance in Toxoplasma gondii Decreases the Accumulation of Reactive Oxygen Species but Does Not Target Parasite Thioredoxin Reductase. Front Cell Infect Microbiol. 2021; 11:618994. Ma CI, Tirtorahardjo JA, Jan S, Schweizer SS, Rosario SAC, Du Y, Zhang JJ, Morrissette NS, Andrade RM. PMID: 33816332; PMCID: PMC8017268.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    7. A Toxoplasma gondii patatin-like phospholipase contributes to host cell invasion. PLoS Pathog. 2020 07; 16(7):e1008650. Wilson SK, Heckendorn J, Martorelli Di Genova B, Koch LL, Rooney PJ, Morrissette N, Lebrun M, Knoll LJ. PMID: 32628723; PMCID: PMC7365478.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    8. The tubulin mutation database: A resource for the cytoskeleton community. Cytoskeleton (Hoboken). 2019 02; 76(2):186-191. Pham CL, Morrissette NS. PMID: 30667171.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    9. From B to A: making an essential cofactor in a human parasite. Biochem J. 2017 08 30; 474(18):3089-3092. Morrissette NS, Goulding CW. PMID: 28860337.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    10. Basal body structure and composition in the apicomplexans Toxoplasma and Plasmodium. Cilia. 2015; 5:3. Francia ME, Dubremetz JF, Morrissette NS. PMID: 26855772; PMCID: PMC4743101.
      View in: PubMed   Mentions: 31  
    11. An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite Toxoplasma gondii. Mol Biol Cell. 2016 Feb 01; 27(3):549-71. Liu J, He Y, Benmerzouga I, Sullivan WJ, Morrissette NS, Murray JM, Hu K. PMID: 26680740; PMCID: PMC4751604.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    12. Extracellular Toxoplasma gondii tachyzoites metabolize and incorporate unnatural sugars into cellular proteins. Microbes Infect. 2016 Mar; 18(3):199-210. Nazarova LA, Ochoa RJ, Jones KA, Morrissette NS, Prescher JA. PMID: 26687036; PMCID: PMC5337115.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Compartmentalized Toxoplasma EB1 bundles spindle microtubules to secure accurate chromosome segregation. Mol Biol Cell. 2015 Dec 15; 26(25):4562-76. Chen CT, Kelly M, Leon Jd, Nwagbara B, Ebbert P, Ferguson DJ, Lowery LA, Morrissette N, Gubbels MJ. PMID: 26466679; PMCID: PMC4678015.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    14. Ingenious strategies of microbial pathogens. Mol Biol Cell. 2015 Mar 15; 26(6):1007. Morrissette NS, Machner MP. PMID: 25767198; PMCID: PMC4357497.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Targeting Toxoplasma tubules: tubulin, microtubules, and associated proteins in a human pathogen. Eukaryot Cell. 2015 Jan; 14(1):2-12. Morrissette N. PMID: 25380753; PMCID: PMC4279016.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    16. Diaryl and heteroaryl sulfides: synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents. J Org Chem. 2014 Mar 07; 79(5):1947-53. Yonova IM, Osborne CA, Morrissette NS, Jarvo ER. PMID: 24564865; PMCID: PMC3985953.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Stereospecific nickel-catalyzed cross-coupling reactions of alkyl Grignard reagents and identification of selective anti-breast-cancer agents. Angew Chem Int Ed Engl. 2014 Feb 24; 53(9):2422-2427. Yonova IM, Johnson AG, Osborne CA, Moore CE, Morrissette NS, Jarvo ER. PMID: 24478275; PMCID: PMC3991427.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    18. A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components. Eukaryot Cell. 2013 Jul; 12(7):1009-19. de Leon JC, Scheumann N, Beatty W, Beck JR, Tran JQ, Yau C, Bradley PJ, Gull K, Wickstead B, Morrissette NS. PMID: 23687115; PMCID: PMC3697468.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    19. Cell division in Apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella. PLoS Biol. 2012; 10(12):e1001444. Francia ME, Jordan CN, Patel JD, Sheiner L, Demerly JL, Fellows JD, de Leon JC, Morrissette NS, Dubremetz JF, Striepen B. PMID: 23239939; PMCID: PMC3519896.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    20. SPM1 stabilizes subpellicular microtubules in Toxoplasma gondii. Eukaryot Cell. 2012 Feb; 11(2):206-16. Tran JQ, Li C, Chyan A, Chung L, Morrissette NS. PMID: 22021240; PMCID: PMC3272897.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    21. α-Tubulin mutations alter oryzalin affinity and microtubule assembly properties to confer dinitroaniline resistance. Eukaryot Cell. 2010 Dec; 9(12):1825-34. Lyons-Abbott S, Sackett DL, Wloga D, Gaertig J, Morgan RE, Werbovetz KA, Morrissette NS. PMID: 20870876; PMCID: PMC3008275.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    22. MEC-17 is an alpha-tubulin acetyltransferase. Nature. 2010 Sep 09; 467(7312):218-22. Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J. PMID: 20829795; PMCID: PMC2938957.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansAnimalsCells
    23. A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division. PLoS Pathog. 2010 Sep 09; 6(9):e1001094. Beck JR, Rodriguez-Fernandez IA, de Leon JC, Huynh MH, Carruthers VB, Morrissette NS, Bradley PJ. PMID: 20844581; PMCID: PMC2936552.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. RNG1 is a late marker of the apical polar ring in Toxoplasma gondii. Cytoskeleton (Hoboken). 2010 Sep; 67(9):586-98. Tran JQ, de Leon JC, Li C, Huynh MH, Beatty W, Morrissette NS. PMID: 20658557; PMCID: PMC2998517.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    25. Synthesis and evaluation of oryzalin analogs against Toxoplasma gondii. Bioorg Med Chem Lett. 2010 Sep 01; 20(17):5179-83. Endeshaw MM, Li C, de Leon J, Yao N, Latibeaudiere K, Premalatha K, Morrissette N, Werbovetz KA. PMID: 20675138; PMCID: PMC2922421.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    26. Host cell invasion by Toxoplasma gondii is temporally regulated by the host microtubule cytoskeleton. Eukaryot Cell. 2010 Nov; 9(11):1680-9. Sweeney KR, Morrissette NS, LaChapelle S, Blader IJ. PMID: 20435700; PMCID: PMC2976295.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    27. Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin. Antimicrob Agents Chemother. 2010 Apr; 54(4):1453-60. Ma C, Tran J, Gu F, Ochoa R, Li C, Sept D, Werbovetz K, Morrissette N. PMID: 20145086; PMCID: PMC2849357.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    28. Isolating tubulin from nonneural sources. Methods Cell Biol. 2010; 95:17-32. Sackett DL, Werbovetz KA, Morrissette NS. PMID: 20466127.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. The early years of Toxoplasma research: What's past is prologue. Int J Parasitol. 2009 Jul 01; 39(8):865-9. Morrissette NS, Ajioka JW. PMID: 19250939; PMCID: PMC2727930.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    30. A century of Toxoplasma research. Int J Parasitol. 2009 Jul 01; 39(8):859-60. Ajioka JW, Morrissette NS. PMID: 19248783; PMCID: PMC2693343.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    31. The cell-penetrating peptide, Pep-1, has activity against intracellular chlamydial growth but not extracellular forms of Chlamydia trachomatis. J Antimicrob Chemother. 2009 Jan; 63(1):115-23. Park N, Yamanaka K, Tran D, Chandrangsu P, Akers JC, de Leon JC, Morrissette NS, Selsted ME, Tan M. PMID: 18957395; PMCID: PMC2721699.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    32. FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16677-82. Bell BD, Leverrier S, Weist BM, Newton RH, Arechiga AF, Luhrs KA, Morrissette NS, Walsh CM. PMID: 18946037; PMCID: PMC2575479.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    33. Secondary mutations correct fitness defects in Toxoplasma gondii with dinitroaniline resistance mutations. Genetics. 2008 Oct; 180(2):845-56. Ma C, Tran J, Li C, Ganesan L, Wood D, Morrissette N. PMID: 18780736; PMCID: PMC2567385.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    34. Mutations in alpha-tubulin confer dinitroaniline resistance at a cost to microtubule function. Mol Biol Cell. 2007 Dec; 18(12):4711-20. Ma C, Li C, Ganesan L, Oak J, Tsai S, Sept D, Morrissette NS. PMID: 17881728; PMCID: PMC2096588.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    35. Dinitroanilines bind alpha-tubulin to disrupt microtubules. Mol Biol Cell. 2004 Apr; 15(4):1960-8. Morrissette NS, Mitra A, Sept D, Sibley LD. PMID: 14742718; PMCID: PMC379290.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    36. Epsilon-tubulin is an essential component of the centriole. Mol Biol Cell. 2002 Nov; 13(11):3859-69. Dutcher SK, Morrissette NS, Preble AM, Rackley C, Stanga J. PMID: 12429830; PMCID: PMC133598.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    37. Cytoskeleton of apicomplexan parasites. Microbiol Mol Biol Rev. 2002 Mar; 66(1):21-38; table of contents. Morrissette NS, Sibley LD. PMID: 11875126; PMCID: PMC120781.
      View in: PubMed   Mentions: 176     Fields:    Translation:AnimalsCells
    38. Disruption of microtubules uncouples budding and nuclear division in Toxoplasma gondii. J Cell Sci. 2002 Mar 01; 115(Pt 5):1017-25. Morrissette NS, Sibley LD. PMID: 11870220.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    39. Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis. Immunity. 2000 Mar; 12(3):285-92. Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A. PMID: 10755615.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    40. Dynamin 2 is required for phagocytosis in macrophages. J Exp Med. 1999 Dec 20; 190(12):1849-56. Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A. PMID: 10601359; PMCID: PMC2195719.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    41. Isolation and characterization of monoclonal antibodies directed against novel components of macrophage phagosomes. J Cell Sci. 1999 Dec; 112 ( Pt 24):4705-13. Morrissette NS, Gold ES, Guo J, Hamerman JA, Ozinsky A, Bedian V, Aderem AA. PMID: 10574718.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    42. The macrophage--a cell for all seasons. Trends Cell Biol. 1999 May; 9(5):199-201. Morrissette N, Gold E, Aderem A. PMID: 10357607.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    43. Toxoplasma gondii: a family of apical antigens associated with the cytoskeleton. Exp Parasitol. 1998 Jul; 89(3):296-303. Morrissette NS, Roos DS. PMID: 9676707.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    44. Subpellicular microtubules associate with an intramembranous particle lattice in the protozoan parasite Toxoplasma gondii. J Cell Sci. 1997 Jan; 110 ( Pt 1):35-42. Morrissette NS, Murray JM, Roos DS. PMID: 9010782.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    45. Inhibition of Toxoplasma gondii replication by dinitroaniline herbicides. Exp Parasitol. 1996 Dec; 84(3):355-70. Stokkermans TJ, Schwartzman JD, Keenan K, Morrissette NS, Tilney LG, Roos DS. PMID: 8948325.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    46. Characterization of extreme apical antigens from Toxoplasma gondii. Exp Parasitol. 1994 Nov; 79(3):445-59. Morrissette NS, Bedian V, Webster P, Roos DS. PMID: 7525339.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    47. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii. Methods Cell Biol. 1994; 45:27-63. Roos DS, Donald RG, Morrissette NS, Moulton AL. PMID: 7707991.
      View in: PubMed   Mentions: 285     Fields:    Translation:Animals
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