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Morrissette, Naomi

TitleAssociate Professor
InstitutionUniversity of California, Irvine
DepartmentMolecular Biology & Biochemistry
Address3213 McGaugh Hall
Zot 3900
Irvine CA 92697
Phone(949) 824-9243, 2805
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Dinitroaniline Action, Selectivity and Resistance
    NIH/NIAID R01AI067981Jan 1, 2006 - Dec 31, 2012
    Role: Principal Investigator
    Dinitroaniline Specificity for Tubulin
    NIH/NIAID K22AI055790Jul 1, 2004 - Jun 30, 2006
    Role: Principal Investigator
    Toxoplasma and Plasmodium resistance to dinitroanilines
    NIH/NIGMS F32GM020484May 1, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Morrissette NS, Goulding CW. From B to A: making an essential cofactor in a human parasite. Biochem J. 2017 08 30; 474(18):3089-3092. PMID: 28860337.
      View in: PubMed
    2. Francia ME, Dubremetz JF, Morrissette NS. Basal body structure and composition in the apicomplexans Toxoplasma and Plasmodium. Cilia. 2015; 5:3. PMID: 26855772; PMCID: PMC4743101.
    3. Liu J, He Y, Benmerzouga I, Sullivan WJ, Morrissette NS, Murray JM, Hu K. An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite Toxoplasma gondii. Mol Biol Cell. 2016 Feb 01; 27(3):549-71. PMID: 26680740; PMCID: PMC4751604.
    4. Nazarova LA, Ochoa RJ, Jones KA, Morrissette NS, Prescher JA. Extracellular Toxoplasma gondii tachyzoites metabolize and incorporate unnatural sugars into cellular proteins. Microbes Infect. 2016 Mar; 18(3):199-210. PMID: 26687036.
      View in: PubMed
    5. Chen CT, Kelly M, Leon Jd, Nwagbara B, Ebbert P, Ferguson DJ, Lowery LA, Morrissette N, Gubbels MJ. Compartmentalized Toxoplasma EB1 bundles spindle microtubules to secure accurate chromosome segregation. Mol Biol Cell. 2015 Dec 15; 26(25):4562-76. PMID: 26466679; PMCID: PMC4678015.
    6. Morrissette NS, Machner MP. Ingenious strategies of microbial pathogens. Mol Biol Cell. 2015 Mar 15; 26(6):1007. PMID: 25767198; PMCID: PMC4357497.
    7. Morrissette N. Targeting Toxoplasma tubules: tubulin, microtubules, and associated proteins in a human pathogen. Eukaryot Cell. 2015 Jan; 14(1):2-12. PMID: 25380753; PMCID: PMC4279016.
    8. Yonova IM, Osborne CA, Morrissette NS, Jarvo ER. Diaryl and heteroaryl sulfides: synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents. J Org Chem. 2014 Mar 07; 79(5):1947-53. PMID: 24564865; PMCID: PMC3985953.
    9. Yonova IM, Johnson AG, Osborne CA, Moore CE, Morrissette NS, Jarvo ER. Stereospecific nickel-catalyzed cross-coupling reactions of alkyl Grignard reagents and identification of selective anti-breast-cancer agents. Angew Chem Int Ed Engl. 2014 Feb 24; 53(9):2422-2427. PMID: 24478275; PMCID: PMC3991427.
    10. de Leon JC, Scheumann N, Beatty W, Beck JR, Tran JQ, Yau C, Bradley PJ, Gull K, Wickstead B, Morrissette NS. A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components. Eukaryot Cell. 2013 Jul; 12(7):1009-19. PMID: 23687115; PMCID: PMC3697468.
    11. Francia ME, Jordan CN, Patel JD, Sheiner L, Demerly JL, Fellows JD, de Leon JC, Morrissette NS, Dubremetz JF, Striepen B. Cell division in Apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella. PLoS Biol. 2012; 10(12):e1001444. PMID: 23239939; PMCID: PMC3519896.
    12. Tran JQ, Li C, Chyan A, Chung L, Morrissette NS. SPM1 stabilizes subpellicular microtubules in Toxoplasma gondii. Eukaryot Cell. 2012 Feb; 11(2):206-16. PMID: 22021240.
      View in: PubMed
    13. Lyons-Abbott S, Sackett DL, Wloga D, Gaertig J, Morgan RE, Werbovetz KA, Morrissette NS. a-Tubulin mutations alter oryzalin affinity and microtubule assembly properties to confer dinitroaniline resistance. Eukaryot Cell. 2010 Dec; 9(12):1825-34. PMID: 20870876; PMCID: PMC3008275.
    14. Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J. MEC-17 is an alpha-tubulin acetyltransferase. Nature. 2010 Sep 09; 467(7312):218-22. PMID: 20829795; PMCID: PMC2938957.
    15. Beck JR, Rodriguez-Fernandez IA, de Leon JC, Huynh MH, Carruthers VB, Morrissette NS, Bradley PJ. A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division. PLoS Pathog. 2010 Sep 09; 6(9):e1001094. PMID: 20844581; PMCID: PMC2936552.
    16. Tran JQ, de Leon JC, Li C, Huynh MH, Beatty W, Morrissette NS. RNG1 is a late marker of the apical polar ring in Toxoplasma gondii. Cytoskeleton (Hoboken). 2010 Sep; 67(9):586-98. PMID: 20658557; PMCID: PMC2998517.
    17. Endeshaw MM, Li C, de Leon J, Yao N, Latibeaudiere K, Premalatha K, Morrissette N, Werbovetz KA. Synthesis and evaluation of oryzalin analogs against Toxoplasma gondii. Bioorg Med Chem Lett. 2010 Sep 01; 20(17):5179-83. PMID: 20675138; PMCID: PMC2922421.
    18. Sweeney KR, Morrissette NS, LaChapelle S, Blader IJ. Host cell invasion by Toxoplasma gondii is temporally regulated by the host microtubule cytoskeleton. Eukaryot Cell. 2010 Nov; 9(11):1680-9. PMID: 20435700; PMCID: PMC2976295.
    19. Ma C, Tran J, Gu F, Ochoa R, Li C, Sept D, Werbovetz K, Morrissette N. Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin. Antimicrob Agents Chemother. 2010 Apr; 54(4):1453-60. PMID: 20145086; PMCID: PMC2849357.
    20. Sackett DL, Werbovetz KA, Morrissette NS. Isolating tubulin from nonneural sources. Methods Cell Biol. 2010; 95:17-32. PMID: 20466127.
      View in: PubMed
    21. Morrissette NS, Ajioka JW. The early years of Toxoplasma research: What's past is prologue. Int J Parasitol. 2009 Jul 01; 39(8):865-9. PMID: 19250939; PMCID: PMC2727930.
    22. Ajioka JW, Morrissette NS. A century of Toxoplasma research. Int J Parasitol. 2009 Jul 01; 39(8):859-60. PMID: 19248783; PMCID: PMC2693343.
    23. Park N, Yamanaka K, Tran D, Chandrangsu P, Akers JC, de Leon JC, Morrissette NS, Selsted ME, Tan M. The cell-penetrating peptide, Pep-1, has activity against intracellular chlamydial growth but not extracellular forms of Chlamydia trachomatis. J Antimicrob Chemother. 2009 Jan; 63(1):115-23. PMID: 18957395; PMCID: PMC2721699.
    24. Bell BD, Leverrier S, Weist BM, Newton RH, Arechiga AF, Luhrs KA, Morrissette NS, Walsh CM. FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16677-82. PMID: 18946037; PMCID: PMC2575479.
    25. Ma C, Tran J, Li C, Ganesan L, Wood D, Morrissette N. Secondary mutations correct fitness defects in Toxoplasma gondii with dinitroaniline resistance mutations. Genetics. 2008 Oct; 180(2):845-56. PMID: 18780736; PMCID: PMC2567385.
    26. Ma C, Li C, Ganesan L, Oak J, Tsai S, Sept D, Morrissette NS. Mutations in alpha-tubulin confer dinitroaniline resistance at a cost to microtubule function. Mol Biol Cell. 2007 Dec; 18(12):4711-20. PMID: 17881728; PMCID: PMC2096588.
    27. Morrissette NS, Mitra A, Sept D, Sibley LD. Dinitroanilines bind alpha-tubulin to disrupt microtubules. Mol Biol Cell. 2004 Apr; 15(4):1960-8. PMID: 14742718; PMCID: PMC379290.
    28. Dutcher SK, Morrissette NS, Preble AM, Rackley C, Stanga J. Epsilon-tubulin is an essential component of the centriole. Mol Biol Cell. 2002 Nov; 13(11):3859-69. PMID: 12429830; PMCID: PMC133598.
    29. Morrissette NS, Sibley LD. Disruption of microtubules uncouples budding and nuclear division in Toxoplasma gondii. J Cell Sci. 2002 Mar 01; 115(Pt 5):1017-25. PMID: 11870220.
      View in: PubMed
    30. Morrissette NS, Sibley LD. Cytoskeleton of apicomplexan parasites. Microbiol Mol Biol Rev. 2002 Mar; 66(1):21-38; table of contents. PMID: 11875126; PMCID: PMC120781.
    31. Morrissette NS, Roos DS. Toxoplasma gondii: a family of apical antigens associated with the cytoskeleton. Exp Parasitol. 1998 Jul; 89(3):296-303. PMID: 9676707.
      View in: PubMed
    32. Morrissette NS, Murray JM, Roos DS. Subpellicular microtubules associate with an intramembranous particle lattice in the protozoan parasite Toxoplasma gondii. J Cell Sci. 1997 Jan; 110 ( Pt 1):35-42. PMID: 9010782.
      View in: PubMed
    33. Stokkermans TJ, Schwartzman JD, Keenan K, Morrissette NS, Tilney LG, Roos DS. Inhibition of Toxoplasma gondii replication by dinitroaniline herbicides. Exp Parasitol. 1996 Dec; 84(3):355-70. PMID: 8948325.
      View in: PubMed
    34. Morrissette NS, Bedian V, Webster P, Roos DS. Characterization of extreme apical antigens from Toxoplasma gondii. Exp Parasitol. 1994 Nov; 79(3):445-59. PMID: 7525339.
      View in: PubMed
    35. Roos DS, Donald RG, Morrissette NS, Moulton AL. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii. Methods Cell Biol. 1994; 45:27-63. PMID: 7707991.
      View in: PubMed
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