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Frances Anne Jurnak

Title(s)Professor Emeritus, Physiology and Biophysics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-5865
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    COMPLETE AREA DETECTOR SYSTEM FOR BIOTECHNOLOGY RESEARCH
    NIH S10RR005070Jun 14, 1989 - Jun 13, 1990
    Role: Principal Investigator
    BIOCHEMICAL AND STRUCTURAL STUDIES OF ELONGATION FACTORS
    NIH R01GM026895Aug 1, 1979 - Nov 30, 1996
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. The Pivotal Role of Aldehyde Toxicity in Autism Spectrum Disorder: The Therapeutic Potential of Micronutrient Supplementation. Nutr Metab Insights. 2015; 8(Suppl 1):57-77. Jurnak F. PMID: 27330305.
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    2. Dancer perceptions of the cognitive, social, emotional, and physical benefits of modern styles of partnered dancing. Complement Ther Med. 2016 Jun; 26:117-22. Lakes KD, Marvin S, Rowley J, Nicolas MS, Arastoo S, Viray L, Orozco A, Jurnak F. PMID: 27261991.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. . 2009 Feb; 8(2):458-68. Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Hoang BH, Zi X. PMID: 19174556.
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    4. Investigation of folding of purified recombinant GRA1 protein using web based protein disorder servers and trypsin digestion. Protein Pept Lett. 2009; 16(7):834-41. Döskaya M, Caner A, Degirmenci A, Jurnak F, Gürüz Y. PMID: 19601915.
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    5. Discerning the Mauve factor, Part 2. Altern Ther Health Med. 2008 May-Jun; 14(3):56-62. McGinnis WR, Audhya T, Walsh WJ, Jackson JA, McLaren-Howard J, Lewis A, Lauda PH, Bibus DM, Jurnak F, Lietha R, Hoffer A. PMID: 18517107.
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    6. Discerning the Mauve Factor, Part 1. Altern Ther Health Med. 2008 Mar-Apr; 14(2):40-50. McGinnis WR, Audhya T, Walsh WJ, Jackson JA, McLaren-Howard J, Lewis A, Lauda PH, Bibus DM, Jurnak F, Lietha R, Hoffer A. PMID: 18383989.
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    7. Expression of Wnt pathway components frizzled and disheveled in colon cancer arising in patients with inflammatory bowel disease. Oncol Rep. 2007 Sep; 18(3):691-4. You XJ, Bryant PJ, Jurnak F, Holcombe RF. PMID: 17671721.
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    8. GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine. Vaccine. 2007 Feb 26; 25(10):1824-37. Döskaya M, Kalantari-Dehaghi M, Walsh CM, Hiszczynska-Sawicka E, Davies DH, Felgner PL, Larsen LS, Lathrop RH, Hatfield GW, Schulz JR, Gürüz Y, Jurnak F. PMID: 17234306.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    9. Molecular complementarity between tetracycline and the GTPase active site of elongation factor Tu. Acta Crystallogr D Biol Crystallogr. 2006 Nov; 62(Pt 11):1392-400. Heffron SE, Mui S, Aorora A, Abel K, Bergmann E, Jurnak F. PMID: 17057344.
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    10. Solving the structure of Escherichia coli elongation factor Tu using a twinned data set. Acta Crystallogr D Biol Crystallogr. 2006 Apr; 62(Pt 4):433-8. Heffron SE, Moeller R, Jurnak F. PMID: 16552145.
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    11. Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor. . 2005 Dec; 4(12):1923-35. Yang S, Irani K, Heffron SE, Jurnak F, Meyskens FL. PMID: 16373707.
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    12. Resolving the space-group ambiguity of crystals of tomato fruit polygalacturonase. Acta Crystallogr D Biol Crystallogr. 2003 Dec; 59(Pt 12):2088-93. Heffron S, Watkins S, Moeller R, Taban AH, Butowt R, DellaPenna D, Jurnak F. PMID: 14646066.
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    13. EF-Tu binding peptides identified, dissected, and affinity optimized by phage display. Chem Biol. 2003 Feb; 10(2):161-8. Murase K, Morrison KL, Tam PY, Stafford RL, Jurnak F, Weiss GA. PMID: 12618188.
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    14. Characterization and implications of Ca2+ binding to pectate lyase C. J Biol Chem. 2003 Apr 04; 278(14):12271-7. Herron SR, Scavetta RD, Garrett M, Legner M, Jurnak F. PMID: 12540845.
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    15. GE2270A-resistant mutations in elongation factor Tu allow productive aminoacyl-tRNA binding to EF-Tu.GTP.GE2270A complexes. J Mol Biol. 2000 Dec 15; 304(5):995-1005. Zuurmond AM, Martien de Graaf J, Olsthoorn-Tieleman LN, van Duyl BY, Mörhle VG, Jurnak F, Mesters JR, Hilgenfeld R, Kraal B. PMID: 11124042.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    16. Structure and function of pectic enzymes: virulence factors of plant pathogens. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):8762-9. Herron SR, Benen JA, Scavetta RD, Visser J, Jurnak F. PMID: 10922032.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    17. Structure of an EF-Tu complex with a thiazolyl peptide antibiotic determined at 2.35 A resolution: atomic basis for GE2270A inhibition of EF-Tu. Biochemistry. 2000 Jan 11; 39(1):37-45. Heffron SE, Jurnak F. PMID: 10625477.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    18. Structure of a plant cell wall fragment complexed to pectate lyase C. Plant Cell. 1999 Jun; 11(6):1081-92. Scavetta RD, Herron SR, Hotchkiss AT, Kita N, Keen NT, Benen JA, Kester HC, Visser J, Jurnak F. PMID: 10368179.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    19. Sequence profile of the parallel beta helix in the pectate lyase superfamily. J Struct Biol. 1998; 122(1-2):223-35. Heffron S, Moe GR, Sieber V, Mengaud J, Cossart P, Vitali J, Jurnak F. PMID: 9724624.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    20. The tree-dimensional structure of aspergillus niger pectin lyase B at 1.7-A resolution. Plant Physiol. 1998 Jan; 116(1):69-80. Vitali J, Schick B, Kester HC, Visser J, Jurnak F. PMID: 9449837.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    21. Differential effect of site-directed mutations in pelC on pectate lyase activity, plant tissue maceration, and elicitor activity. J Biol Chem. 1996 Oct 25; 271(43):26529-35. Kita N, Boyd CM, Garrett MR, Jurnak F, Keen NT. PMID: 8900122.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    22. An alpha to beta conformational switch in EF-Tu. Structure. 1996 Oct 15; 4(10):1153-9. Abel K, Yoder MD, Hilgenfeld R, Jurnak F. PMID: 8939740.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    23. The Refined Three-Dimensional Structure of Pectate Lyase E from Erwinia chrysanthemi at 2.2 A Resolution. Plant Physiol. 1996 May; 111(1):73-92. Lietzke SE, Scavetta RD, Yoder MD, Jurnak F. PMID: 12226275.
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    24. A complex profile of protein elongation: translating chemical energy into molecular movement. Structure. 1996 Mar 15; 4(3):229-38. Abel K, Jurnak F. PMID: 8805530.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    25. Circular dichroism of the parallel beta helical proteins pectate lyase C and E. Proteins. 1995 Sep; 23(1):32-7. Sieber V, Jurnak F, Moe GR. PMID: 8539248.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    26. Structure-based multiple alignment of extracellular pectate lyase sequences. Mol Plant Microbe Interact. 1995 Mar-Apr; 8(2):331-4. Heffron S, Henrissat B, Yoder MD, Lietzke S, Jurnak F. PMID: 7756698.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    27. Protein motifs. 3. The parallel beta helix and other coiled folds. FASEB J. 1995 Mar; 9(5):335-42. Yoder MD, Jurnak F. PMID: 7896002.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    28. Functional implications of structure-based sequence alignment of proteins in the extracellular pectate lyase superfamily. Plant Physiol. 1995 Mar; 107(3):963-76. Henrissat B, Heffron SE, Yoder MD, Lietzke SE, Jurnak F. PMID: 7716248.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    29. The Refined Three-Dimensional Structure of Pectate Lyase C from Erwinia chrysanthemi at 2.2 Angstrom Resolution (Implications for an Enzymatic Mechanism). Plant Physiol. 1995 Feb; 107(2):349-364. Yoder MD, Jurnak F. PMID: 12228363.
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    30. Parallel beta-domains: a new fold in protein structures. Curr Opin Struct Biol. 1994 Dec; 4(6):802-6. Jurnak F, Yoder MD, Pickersgill R, Jenkins J. PMID: 7712282.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    31. Protein-protein interaction. Complex flexibility. Nature. 1994 Dec 01; 372(6505):409-10. Jurnak F. PMID: 7984232.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    32. The Three-Dimensional Structure of Pectate Lyase E, a Plant Virulence Factor from Erwinia chrysanthemi. Plant Physiol. 1994 Nov; 106(3):849-862. Lietzke SE, Yoder MD, Keen NT, Jurnak F. PMID: 12232373.
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    33. The ABC of EF-G. Structure. 1994 Sep 15; 2(9):785-8. Jurnak F. PMID: 7812711.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    34. Extension of the diffraction resolution of crystals. Acta Crystallogr D Biol Crystallogr. 1994 Jul 01; 50(Pt 4):563-8. Schick B, Jurnak F. PMID: 15299419.
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    35. Unusual structural features in the parallel beta-helix in pectate lyases. Structure. 1993 Dec 15; 1(4):241-51. Yoder MD, Lietzke SE, Jurnak F. PMID: 8081738.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    36. New domain motif: the structure of pectate lyase C, a secreted plant virulence factor. Science. 1993 Jun 04; 260(5113):1503-7. Yoder MD, Keen NT, Jurnak F. PMID: 8502994.
      View in: PubMed   Mentions: 101     Fields:    Translation:Cells
    37. An isotope edited classical Raman difference spectroscopic study of the interactions of guanine nucleotides with elongation factor Tu and H-ras p21. Biochemistry. 1991 Nov 12; 30(45):10914-20. Manor D, Weng GZ, Deng H, Cosloy S, Chen CX, Balogh-Nair V, Delaria K, Jurnak F, Callender R. PMID: 1932015.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    38. Stabilization of the Escherichia coli elongation factor Tu-GTP-aminoacyl-tRNA complex. Arch Biochem Biophys. 1991 Apr; 286(1):207-11. Delaria K, Guillen M, Louie A, Jurnak F. PMID: 1897948.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    39. Genetic engineering, isolation and characterization of a truncated Escherichia coli elongation factor Tu comprising domains 2 and 3. Biochim Biophys Acta. 1990 Oct 23; 1087(2):147-56. Pieper U, Ehbrecht HJ, Fliess A, Schick B, Jurnak F, Pingoud A. PMID: 2223877.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    40. Three-dimensional models of the GDP and GTP forms of the guanine nucleotide domain of Escherichia coli elongation factor Tu. Biochim Biophys Acta. 1990 Aug 27; 1050(1-3):209-14. Jurnak F, Heffron S, Schick B, Delaria K. PMID: 2119811.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    41. Preliminary crystallographic analysis of the plant pathogenic factor, pectate lyase C from Erwinia chrysanthemi. J Biol Chem. 1990 Jul 15; 265(20):11429-31. Yoder MD, DeChaine DA, Jurnak F. PMID: 2195018.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    42. Preliminary crystallographic analysis of a complex between tetracycline and the trypsin-modified form of Escherichia coli elongation factor Tu. J Mol Biol. 1990 Apr 05; 212(3):445-7. Mui S, Delaria K, Jurnak F. PMID: 2182884.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    43. Conformational changes involved in the activation of ras p21: implications for related proteins. Cell. 1990 Feb 23; 60(4):525-8. Jurnak F, Heffron S, Bergmann E. PMID: 2105846.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    44. Characterization of precrystallization aggregation of canavalin by dynamic light scattering. Biophys J. 1990 Jan; 57(1):125-32. Kadima W, McPherson A, Dunn MF, Jurnak FA. PMID: 2297559.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    45. Preliminary crystallographic analysis of a plant pathogenic factor: pectate lyase. J Mol Biol. 1989 Jul 20; 208(2):365-7. Kim CY, Mosser V, Keen N, Jurnak F. PMID: 2769765.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    46. Preparation of Escherichia coli elongation factor Tu-guanosine 5'-triphosphate analogs. Anal Biochem. 1989 Feb 15; 177(1):188-93. Delaria K, Jurnak F. PMID: 2662816.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    47. The three-dimensional structure of c-H-ras p21: implications for oncogene and G protein studies. Trends Biochem Sci. 1988 Jun; 13(6):195-8. Jurnak F. PMID: 3151222.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    48. Molecular approaches towards an anti-ras drug. Anticancer Drug Des. 1987 Oct; 2(2):107-15. Sigal IS, Smith GM, Jurnak F, Marsico-Ahern JD, D'Alonzo JS, Scolnick EM, Gibbs JB. PMID: 3130069.
      View in: PubMed   Mentions: 2     Fields:    
    49. Preliminary X-ray diffraction analysis of crystals of Bacillus thuringiensis toxin, a cell membrane disrupting protein. J Mol Biol. 1987 Jun 05; 195(3):755-7. McPherson A, Jurnak F, Singh GJ, Gill SS. PMID: 3656433.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    50. Kinetic studies of Escherichia coli elongation factor Tu-guanosine 5'-triphosphate-aminoacyl-tRNA complexes. Biochemistry. 1985 Nov 05; 24(23):6433-9. Louie A, Jurnak F. PMID: 3910093.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    51. Structure of the GDP domain of EF-Tu and location of the amino acids homologous to ras oncogene proteins. Science. 1985 Oct 04; 230(4721):32-6. Jurnak F. PMID: 3898365.
      View in: PubMed   Mentions: 123     Fields:    Translation:Cells
    52. Bulk preparation and crystallization of the Escherichia coli elongation factor Tu-Ts complex. Anal Biochem. 1985 Oct; 150(1):243-8. Yoder M, Torres C, Corelli R, Jurnak F. PMID: 3909845.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    53. Induction of elongation factor Tu-GDP crystal polymorphism by polyethylene glycol contaminants. J Mol Biol. 1985 Sep 05; 185(1):215-7. Jurnak F. PMID: 3900422.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    54. Effect of trypsin modification of the Escherichia coli elongation factor Tu on the ternary complex with aminoacyl-tRNA. J Biol Chem. 1985 Jul 25; 260(15):8702-5. Masuda E, Louie A, Jurnak F. PMID: 3894346.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    55. Elongation factor Tu ternary complex binds to small ribosomal subunits in a functionally active state. Biochemistry. 1984 Dec 04; 23(25):6171-8. Langer JA, Jurnak F, Lake JA. PMID: 6395891.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    56. An improved bulk purification method for Escherichia coli elongation factor, Ts. Anal Biochem. 1984 Sep; 141(2):351-4. Yoder M, Lennane J, Jurnak F. PMID: 6388412.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    57. Affinity purification of aminoacyl-tRNA. Anal Biochem. 1984 Sep; 141(2):402-8. Louie A, Masuda E, Yoder M, Jurnak F. PMID: 6388413.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    58. Relative affinities of all Escherichia coli aminoacyl-tRNAs for elongation factor Tu-GTP. J Biol Chem. 1984 Apr 25; 259(8):5010-6. Louie A, Ribeiro NS, Reid BR, Jurnak F. PMID: 6370998.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    59. The structure of a DNA unwinding protein and its complexes with oligodeoxynucleotides by x-ray diffraction. Biophys J. 1980 Oct; 32(1):155-73. McPherson A, Jurnak F, Wang A, Kolpak F, Rich A, Molineux I, Fitzgerald P. PMID: 6264986.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    60. Biochemical and structural studies of the tetragonal crystalline modification of the Escherichia coli elongation factor Tu. J Biol Chem. 1980 Jul 25; 255(14):6751-7. Jurnak F, McPherson A, Wang AH, Rich A. PMID: 6993478.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    61. X-ray diffraction studies on crystalline complexes of the gene 5 DNA-unwinding protein with deoxyoligonucleotides. J Biol Chem. 1980 Apr 10; 255(7):3174-7. McPherson A, Wang AH, Jurnak FA, Molineux I, Kolpak F, Rich A. PMID: 6244310.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    62. Structure of the gene 5 DNA binding protein from bacteriophage fd and its DNA binding cleft. Mol Biol Biochem Biophys. 1980; 32:231-40. McPherson A, Wang A, Jurnak F, Molineux I, Rich A. PMID: 6893734.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    63. Structure at 2.3 A resolution of the gene 5 product of bacteriophage fd: a DNA unwinding protein. J Mol Biol. 1979 Nov 05; 134(3):379-400. McPherson A, Jurnak FA, Wang AH, Molineux I, Rich A. PMID: 231669.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    64. Gene-V product of bacteriophage fd: structure of a DNA-unwinding protein and its complexes with DNA. Cold Spring Harb Symp Quant Biol. 1979; 43 Pt 1:21-8. McPherson A, Jurnak F, Wang A, Kolpak F, Molineux I, Rich A. PMID: 225099.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    65. Structure of the DNA binding cleft of the gene 5 protein from bacteriophage fd. J Supramol Struct. 1979; 10(4):457-65. McPherson A, Jurnak F, Wang A, Molineux I, Rich A. PMID: 229356.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    66. Preliminary molecular replacement results for a crystalline gene 4 protein-deoxyoligonucleotide complex. J Supramol Struct. 1979; 10(4):479-89. Fitzgerald PM, Wang AH, McPherson A, Jurnak FA, Molineux I, Kolpak F, Rich A. PMID: 229358.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    67. Preliminary x-ray diffraction data for tetragonal crystals of trypsinized Escherichia coli elongation factor. J Mol Biol. 1977 Sep; 115(1):103-10. Jurnak F, Rich A, Miller D. PMID: 336895.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    68. Preliminary X-ray study of leucine aminopeptidase (bpvine lens), and oligomeric metalloenzyme. J Mol Biol. 1977 May 05; 112(1):149-53. Jurnak F, Rich A, van Loon-Klaassen A, Bloemendal H, Taylor A, Carpenter FH. PMID: 881727.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    69. Chelative Addiction of Hydrazine to Coordinated Isocyanides. The Structure of 1,1'Dichloropallado-2,5-di(methylamino)-3,4-diazacyclopentadiene, [(CH3)2C2N4H4PdCl2)]. Inorg Chem. 1972 Dec 01; 11(12):3149-52. Jurnak FA, Raymond KN. PMID: 25265046.
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