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Christy L Hom

Photo of Christy L Hom
Title(s)Associate Clinical Professor, Psychiatry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-5902
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    Collapse Biography 
    Collapse education and training
    University of Michigan, Ann ArborPh.D.04/2002Clinical Psychology
    University of California, Los AngelesB.A.03/1994Psychology
    Children's Hospital of Orange County12/2003Post-doctoral fellowship
    Collapse awards and honors
    American Board of Pediatric Neuropsychology2014Diplomate
    American Academy of Clinical Neuropsychology2013Member
    American Psychological Association2004Member
    National Academy of Neuropsychology2013Member

    Collapse Overview 
    Collapse overview
    Dr. Christy Hom is a clinical psychologist and board certified pediatric neuropsychologist. She specializes in the assessment of neurodevelopmental disorders, developmental disabilities, traumatic brain injury, seizure disorders, and psychiatric disorders. Her research studies have focused on the structural and functional differences in neural circuitry between adolescents who have and have not experienced maltreatment, cognitive decline in older adults, multisensory treatment for children with Autism , and Alzheimer's disease in persons with Down Syndrome.

    Collapse Research 
    Collapse research activities and funding
    Effects of Childhood Maltreatment on Neurocircuitry in Adolescent Depression
    NIH R01MH108155Aug 1, 2017 - Mar 31, 2023
    Role: Co-Investigator
    Biomarkers of Alzheimer's Disease in Adults with Down Syndrome
    NIH U01AG051412Sep 30, 2015 - Apr 30, 2020
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alzheimer's Disease Research Center Down Syndrome Cores: Experience from two sites. Alzheimers Dement. 2025 Aug; 21(8):e70612. Ptomey L, Hom C, Wilkins H, Doran E, Wright ST, Hoang D, Delehoy B, Lott IT, Perales-Puchalt J, Helsel B, Burns J, Grill JD, Head E. PMID: 40847661; PMCID: PMC12374163.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Preliminary Investigation of Obstructive Sleep Apnea and Alzheimer's Disease in Down Syndrome. Sleep. 2025 Jul 23. Yoon DM, Plante D, Fleming V, Handen B, Lao P, Peven J, Christian B, Okonkwo O, Laymon C, Ances B, Hom C, Helsel B, Hartley SL, Alzheimer Biomarker Consortium - Down syndrome . PMID: 40794806.
      View in: PubMed   Mentions:    Fields:    
    3. Preliminary investigation of obstructive sleep apnea and Alzheimer's disease in down syndrome. Sleep Adv. 2025; 6(3):zpaf044. Yoon DM, Plante DT, Fleming V, Handen B, Lao P, Peven J, Christian B, Okonkwo O, Laymon C, Ances B, Hom C, Helsel B, Hartley SL. PMID: 40917568; PMCID: PMC12413861.
      View in: PubMed   Mentions:
    4. Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross-sectional associations with early cognitive impairments. Alzheimers Dement. 2025 Jul; 21(7):e70424. Fu JF, Garimella A, Lapointe A, Aye WWT, Chen CD, Lee JH, Krinsky-McHale SJ, Zaman S, Lott IT, Hom C, Ances B, Head E, Mapstone M, Lai F, Handen BL, Laymon CM, Hartley SL, Christian BT, Rentz DM, Johnson KA, Rosas HD, Price JC, Alzheimer Biomarkers Consortium–Down Syndrome (ABC-DS). PMID: 40588723; PMCID: PMC12208798.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Lifestyle Composite and Resilience to Alzheimer's Disease Pathology in Down Syndrome. J Appl Res Intellect Disabil. 2025 Jul; 38(4):e70109. Schworer EK, Zammit MD, Handen BL, Piro-Gambetti B, Jenkins MR, Brothers C, Okonkwo OC, Hom CL, Ances BM, Christian BT, Hartley SL. PMID: 40799171; PMCID: PMC12344623.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Leptin levels are associated with body mass index and Alzheimer's disease in Down syndrome. Alzheimers Dement. 2025 Jul; 21(7):e70448. Sordo L, Du A, Sandadi V, Dustagheer FB, Pascual J, Ngo P, Hom CL, Doran E, Head E. PMID: 40635163; PMCID: PMC12240871.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Longitudinal study of body mass index in relation to Alzheimer's disease pathology and symptomatology in Down syndrome. Alzheimers Dement. 2025 Jun; 21(6):e70387. Fleming VL, Helsel BC, Ptomey LT, Handen BL, Krinsky-McHale SJ, Hom CL, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Brickman AM, Pulsifer M, Clare ICH, Rosa HD, Lai F, Harp J, Schmitt F, Price J, Zaman SH, Head E, Mapstone M, Christian BT, Okonkwo O, Hartley SL, Alzheimer's Biomarkers Consortium–Down Syndrome. PMID: 40545561; PMCID: PMC12183108.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Cognitive and Behavioural Associations of Visual and Hearing Impairments Across the Lifespan in People With Down Syndrome, a Scoping Review. J Intellect Disabil Res. 2025 Sep; 69(9):753-780. Betoni NJ, Okamoto CM, Lott IT, Hom CL. PMID: 40377220; PMCID: PMC12418728.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. The Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS): A 10-year report. Alzheimers Dement. 2025 May; 21(5):e70294. Handen BL, Mapstone M, Hartley S, Andrews H, Christian B, Lee JH, Tudorascu D, Hom C, Ances BM, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Petersen M, O'Bryant S, Harp JP, Schmitt F, Ptomey L, Burns J, Lott IT, Lai F, Silverman W, Laymon C, Head E, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 40371686; PMCID: PMC12079517.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Modified Cued Recall Test: Longitudinal Analysis of Test Versions and Item Recall in Adults With Down Syndrome. J Intellect Disabil Res. 2025 Jul; 69(7):569-581. Schworer EK, Handen BL, Krinsky-McHale S, Hom CL, Clare ICH, Harp JP, Pulsifer MB, Mapstone M, Head E, Christian BT, Hartley SL, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 40254895; PMCID: PMC12199718.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Behavioral and psychological symptoms of dementia and Alzheimer's disease progression in Down syndrome. J Neurodev Disord. 2025 Apr 11; 17(1):19. Jenkins MR, Peven JC, Kubic L, Handen BL, Krinsky-McHale SJ, Hom CL, Lee A, Tudorascu DL, McLachlan M, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Rosas HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL, Alzheimer Biomarker Consortium - Down syndrome. PMID: 40217501; PMCID: PMC11987311.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Longitudinal investigation of gait and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement. 2025 Apr; 21(4):e70211. Barry A, Peven JC, Handen BL, Bolt D, Krinsky-McHale SJ, Hom CL, Clare ICH, Glueck A, Harp J, Schmitt F, Zammit M, Minhas D, Luo W, Laymon C, Price J, Lee JH, Lott I, Cohen A, Ances BM, Pulsifer M, Rosa HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL, Alzheimer Biomarker Consortium - Down syndrome. PMID: 40289844; PMCID: PMC12035545.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Resistance and resilience to Alzheimer's disease in Down syndrome. Alzheimers Dement. 2025 04; 21(4):e70151. Boyle R, Koops EA, Ances B, Andrews EJ, Arenaza-Urquijo EM, Bejanin A, Brickman AM, Buckley RF, Clas GS, Costello E, Coughlan GT, Conley AC, Deng F, de Paula Faria D, Edwards N, Flores-Aguilar L, Fortea J, Ghazi Saidi L, Head E, Hom CL, Koenig K, Lao P, Lengyel I, Li YJ, Loi S, Loughrey D, McGlinchey E, Newhouse P, Pertierra L, Prokopiou PC, Qi Q, de Paula França Resende E, Russell J, Scanlon CE, Schneider C, Schultz SA, Seto M, Shaka S, Soldan A, Vaqué Alcázar L, Weng Y, Wilson JE, Zaman SH, Zsadányi SE, Hartley S. PMID: 40289889; PMCID: PMC12035553.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. A neuropathology case report of a woman with Down syndrome who remained cognitively stable: Implications for resilience to neuropathology. Alzheimers Dement. 2025 Feb; 21(2):e14479. Liou JJ, Lou J, Flores-Aguilar L, Nakagiri J, Yong W, Hom CL, Doran EW, Totoiu MO, Lott I, Mapstone M, Keator DB, Brickman AM, Wright ST, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E, Alzheimer Biomarker Consortium - Down Syndrome. PMID: 39868632; PMCID: PMC11851131.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome. EBioMedicine. 2024 Dec; 110:105433. Xicota L, Dang LT, Lee A, Krinsky-McHale S, Pang D, Melilli L, O'Bryant S, Henson RL, Laymon C, Lai F, Rosas HD, Ances B, Lott I, Hom C, Christian B, Hartley S, Zaman S, Head E, Mapstone M, Jin Z, Silverman W, Schupf N, Handen B, Lee JH, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 39500037; PMCID: PMC11570228.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    16. A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable. medRxiv. 2024 Jun 03. Liou JJ, Lou J, Nakagiri J, Yong W, Hom CL, Doran EW, Totoiu M, Lott I, Mapstone M, Keator DB, Brickman AM, Wright S, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E, Alzheimer Biomarker Consortium - Down Syndrome. PMID: 38883742; PMCID: PMC11177914.
      View in: PubMed   Mentions:
    17. A pathway linking pulse pressure to dementia in adults with Down syndrome. Brain Commun. 2024; 6(3):fcae157. Rizvi B, Lao PJ, Sathishkumar M, Taylor L, Queder N, McMillan L, Edwards NC, Keator DB, Doran E, Hom C, Nguyen D, Rosas HD, Lai F, Schupf N, Gutierrez J, Silverman W, Lott IT, Mapstone M, Wilcock DM, Head E, Yassa MA, Brickman AM. PMID: 38764776; PMCID: PMC11099660.
      View in: PubMed   Mentions: 1  
    18. Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome. Alzheimers Dement (Amst). 2024 Apr-Jun; 16(2):e12582. Schworer EK, Handen BL, Petersen M, O'Bryant S, Peven JC, Tudorascu DL, Lee L, Krinsky-McHale SJ, Hom CL, Clare ICH, Christian BT, Schupf N, Lee JH, Head E, Mapstone M, Lott I, Ances BM, Zaman S, Brickman AM, Lai F, Rosas HD, Hartley SL, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 38623384; PMCID: PMC11016818.
      View in: PubMed   Mentions: 14  
    19. Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome. Alzheimers Dement (Amst). 2024 Jan-Mar; 16(1):e12542. DiProspero N, Sathishkumar M, Janecek J, Smith A, McMillan L, Petersen M, Tustison N, Keator DB, Doran E, Hom CL, Nguyen D, Andrews H, Krinsky-McHale S, Brickman AM, Rosas HD, Lai F, Head E, Mapstone M, Silverman W, Lott IT, O'Bryant S, Yassa MA. PMID: 38348178; PMCID: PMC10859879.
      View in: PubMed   Mentions: 5  
    20. Insomnia Symptoms Are Associated with Measures of Functional Deterioration and Dementia Status in Adults with Down Syndrome at High Risk for Alzheimer's Disease. J Alzheimers Dis. 2024; 100(2):613-629. Desai S, Chen IY, Hom C, Doran E, Nguyen DD, Benca RM, Lott IT, Mander BA. PMID: 38875029; PMCID: PMC11307085.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Pathways linking pulse pressure to dementia in adults with Down syndrome. medRxiv. 2023 Oct 26. Rizvi B, Lao PJ, Sathishkumar M, Taylor L, Queder N, McMillan L, Edwards N, Keator DB, Doran E, Hom C, Nguyen D, Rosas HD, Lai F, Schupf N, Gutierrez J, Silverman W, Lott IT, Mapstone M, Wilcock DM, Head E, Yassa MA, Brickman AM. PMID: 37961444; PMCID: PMC10635215.
      View in: PubMed   Mentions:
    22. Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome. Alzheimers Dement. 2024 02; 20(2):1038-1049. Gorijala P, Aslam MM, Dang LT, Xicota L, Fernandez MV, Sung YJ, Fan KH, Feingold E, Surace EI, Chhatwal JP, Hom CL, Dominantly Inherited Alzheimer Network (DIAN), the Alzheimer's Disease Neuroimaging Initiative (ADNI, NIA-LOAD family study, for the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS) Investigator, Hartley SL, Hassenstab J, Perrin RJ, Mapstone M, Zaman SH, Ances BM, Kamboh MI, Lee JH, Cruchaga C. PMID: 37855447; PMCID: PMC10916941.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    23. Timing of Alzheimer's Disease by Intellectual Disability Level in Down Syndrome. J Alzheimers Dis. 2023; 95(1):213-225. Hartley SL, Fleming V, Schworer EK, Peven J, Handen BL, Krinsky-McHale S, Hom C, Lee L, Tudorascu DL, Laymon C, Minhas D, Luo W, Cohen A, Zaman S, Ances BM, Mapstone M, Head E, Lai F, Rosas HD, Klunk W, Christian B, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 37482997; PMCID: PMC10578224.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. A modified Cued Recall Test for detecting prodromal AD in adults with Down syndrome. Alzheimers Dement (Amst). 2022; 14(1):e12361. Krinsky-McHale SJ, Hartley S, Hom C, Pulsifer M, Clare ICH, Handen BL, Lott IT, Schupf N, Silverman W, Alzheimer's Biomarker Consortium—Down Syndrome (ABC-DS) Investigators. PMID: 36212742; PMCID: PMC9527593.
      View in: PubMed   Mentions: 18  
    25. Cognitive outcome measures for tracking Alzheimer's disease in Down syndrome. Int Rev Res Dev Disabil. 2022; 62:227-263. Fleming V, Hom CL, Clare ICH, Hurd-Thomas SL, Krinsky-McHale S, Handen B, Hartley SL. PMID: 37396708; PMCID: PMC10312212.
      View in: PubMed   Mentions: 3  
    26. Correction: Hom et al. Cognitive Function during the Prodromal Stage of Alzheimer's Disease in Down Syndrome: Comparing Models. BrainSci. 2021, 11, 1220. Brain Sci. 2022 Jul 15; 12(7). Hom CL, Kirby KA, Ricks-Oddie J, Keator DB, Krinsky-McHale SJ, Pulsifer MB, Rosas HD, Lai F, Schupf N, Lott IT, Silverman W. PMID: 35884766; PMCID: PMC9313374.
      View in: PubMed   Mentions:
    27. Joint-label fusion brain atlases for dementia research in Down syndrome. Alzheimers Dement (Amst). 2022; 14(1):e12324. Queder N, Phelan MJ, Taylor L, Tustison N, Doran E, Hom C, Nguyen D, Lai F, Pulsifer M, Price J, Kreisl WC, Rosas HD, Krinsky-McHale S, Brickman AM, Yassa MA, Schupf N, Silverman W, Lott IT, Head E, Mapstone M, Keator DB, Alzheimer's Biomarkers Consortium. PMID: 35634535; PMCID: PMC9131930.
      View in: PubMed   Mentions: 5  
    28. Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome. Disabil Health J. 2022 07; 15(3):101278. Hartley SL, Fleming V, Piro-Gambetti B, Cohen A, Ances BM, Yassa MA, Brickman AM, Handen BL, Head E, Mapstone M, Christian BT, Lott IT, Doran E, Zaman S, Krinsky-McHale S, Schmitt FA, Hom C, Schupf N, ABC-DS Group. PMID: 35256308; PMCID: PMC8849846.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    29. Cognitive Function during the Prodromal Stage of Alzheimer's Disease in Down Syndrome: Comparing Models. Brain Sci. 2021 Sep 16; 11(9). Hom CL, Kirby KA, Ricks-Oddie J, Keator DB, Krinsky-McHale SJ, Pulsifer MB, Rosas HD, Lai F, Schupf N, Lott IT, Silverman W. PMID: 34573242; PMCID: PMC8471085.
      View in: PubMed   Mentions: 8  
    30. Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome. Brain Sci. 2021 Aug 25; 11(9). Harp JP, Koehl LM, Pelt KLV, Hom CL, Doran E, Head E, Lott IT, Schmitt FA. PMID: 34573150; PMCID: PMC8468129.
      View in: PubMed   Mentions: 5  
    31. Cognitive assessment using the Rapid Assessment for Developmental Disabilities, Second Edition (RADD-2). J Intellect Disabil Res. 2021 09; 65(9):831-848. Hom CL, Walsh D, Fernandez G, Tournay A, Touchette P, Lott IT. PMID: 34196436.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    32. Evaluation of the National Task Group-Early Detection Screen for Dementia: Sensitivity to 'mild cognitive impairment' in adults with Down syndrome. J Appl Res Intellect Disabil. 2021 May; 34(3):905-915. Silverman W, Krinsky-McHale SJ, Lai F, Diana Rosas H, Hom C, Doran E, Pulsifer M, Lott I, Schupf N, Alzheimer’s Disease in Down Syndrome (ADDS) Consortium. PMID: 33314467; PMCID: PMC8356176.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    33. Brain amyloid and the transition to dementia in Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12126. Keator DB, Doran E, Taylor L, Phelan MJ, Hom C, Tseung K, van Erp TGM, Potkin SG, Brickman AM, Rosas DH, Yassa MA, Silverman W, Lott IT. PMID: 33204814; PMCID: PMC7656170.
      View in: PubMed   Mentions: 8  
    34. Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD? Alzheimers Dement (Amst). 2020; 12(1):e12040. Rosas HD, Hsu E, Mercaldo ND, Lai F, Pulsifer M, Keator D, Brickman AM, Price J, Yassa M, Hom C, Krinsky-McHale SJ, Silverman W, Lott I, Schupf N. PMID: 33204811; PMCID: PMC7648416.
      View in: PubMed   Mentions: 16  
    35. Language skills as a predictor of cognitive decline in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12080. Pulsifer MB, Evans CL, Hom C, Krinsky-McHale SJ, Silverman W, Lai F, Lott I, Schupf N, Wen J, Rosas HD. PMID: 32875055; PMCID: PMC7447889.
      View in: PubMed   Mentions: 14  
    36. Down syndrome: Distribution of brain amyloid in mild cognitive impairment. Alzheimers Dement (Amst). 2020; 12(1):e12013. Keator DB, Phelan MJ, Taylor L, Doran E, Krinsky-McHale S, Price J, Ballard EE, Kreisl WC, Hom C, Nguyen D, Pulsifer M, Lai F, Rosas DH, Brickman AM, Schupf N, Yassa MA, Silverman W, Lott IT. PMID: 32435685; PMCID: PMC7233421.
      View in: PubMed   Mentions: 11  
    37. Self-concept in children with Down syndrome. Am J Med Genet A. 2014 Aug; 164A(8):1891-8. Saha S, Doran E, Osann KE, Hom C, Movsesyan N, Rosa DD, Tournay A, Lott IT. PMID: 24838927; PMCID: PMC5800412.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    38. The relationship between living arrangement and adherence to antiepileptic medications among individuals with developmental disabilities. J Intellect Disabil Res. 2015 Jan; 59(1):48-54. Hom CL, Touchette P, Nguyen V, Fernandez G, Tournay A, Plon L, Himber P, Lott IT. PMID: 24612032.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    39. Other rheumatic diseases in adolescence. Dermatomyositis, scleroderma, overlap syndromes, systemic vasculitis, and panniculitis. Adolesc Med. 1998 Feb; 9(1):69-83, vi. Hom C, Ilowite NT. PMID: 10961253.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    40. Effects of equal and unequal reinforcer duration during functional analysis. J Appl Behav Anal. 1996; 29(1):117-20. Fisher WW, Piazza CC, Chiang CL. PMID: 8881352; PMCID: PMC1279881.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
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