Bryce A Mander

Title(s)Associate Professor, Psychiatry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6742
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    Collapse Research 
    Collapse Research Activities and Funding
    Relationships between local and global mechanisms of sleep apnea, Alzheimer's disease biomarkers, and memory impairment in cognitively asymptomatic older adults
    NIH K01AG068353Aug 1, 2020 - Apr 30, 2025
    Role: Principal Investigator
    Aging, sleep, and beta-amyloid pathology and their impact on memory
    NIH F32AG039170Dec 1, 2010 - Nov 30, 2013
    Role: Principal Investigator
    The neural response to sleep loss in the elderly
    NIH F31MH074291Sep 30, 2005 - Sep 29, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study. Alzheimers Dement. 2024 Apr 11. Melikyan ZA, Kawas CH, Paganini-Hill A, Jiang L, Bukhari S, Montine TJ, Mander BA, Corrada MM. PMID: 38602280.
      View in: PubMed   Mentions:
    2. Spindle oscillations in communicating axons within a reconstituted hippocampal formation are strongest in CA3 without thalamus. Sci Rep. 2024 04 10; 14(1):8384. Wang M, Lassers SB, Vakilna YS, Mander BA, Tang WC, Brewer GJ. PMID: 38600114; PMCID: PMC11006914.
      View in: PubMed   Mentions:
    3. Correction to: Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum. Neurol Sci. 2024 Apr; 45(4):1813. Ferini-Strambi L, Liguori C, Lucey BP, Mander BA, Spira AP, Videnovic A, Baumann C, Franco O, Fernandes M, Gnarra O, Krack P, Manconi M, Noain D, Saxena S, Kallweit U, Randerath W, Trenkwalder C, Rosenzweig I, Iranzo A, Bradicich M, Bassetti C. PMID: 38326667.
      View in: PubMed   Mentions:    Fields:    
    4. Cerebrovascular pathology mediates associations between hypoxemia during rapid eye movement sleep and medial temporal lobe structure and function in older adults. bioRxiv. 2024 Jan 28. Berisha DE, Rizvi B, Chappel-Farley MG, Tustison N, Taylor L, Dave A, Sattari NS, Chen IY, Lui KK, Janecek JC, Keator D, Neikrug AB, Benca RM, Yassa MA, Mander BA. PMID: 38328085; PMCID: PMC10849660.
      View in: PubMed   Mentions:
    5. Cardiorespiratory fitness and circadian rhythms in adolescents: a pilot study. J Appl Physiol (1985). 2024 Feb 01; 136(2):372-384. Chen IY, Radom-Aizik S, Stehli A, Palmer JR, Lui KK, Dave A, Chappel-Farley MG, Vinces KG, Gealer D, Lim A, Mander BA, Benca RM, Neikrug AB. PMID: 38126092.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum. Neurol Sci. 2024 Feb; 45(2):749-767. Ferini-Strambi L, Liguori C, Lucey BP, Mander BA, Spira AP, Videnovic A, Baumann C, Franco O, Fernandes M, Gnarra O, Krack P, Manconi M, Noain D, Saxena S, Kallweit U, Randerath W, Trenkwalder C, Rosenzweig I, Iranzo A, Bradicich M, Bassetti C. PMID: 38087143.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Older adults at greater risk for Alzheimer's disease show stronger associations between sleep apnea severity and verbal memory. Res Sq. 2023 Dec 02. Lui K, Dave A, Sprecher K, Chappel-Farley M, Riedner B, Heston M, Taylor C, Carlsson C, Okonkwo O, Asthana S, Johnson S, Bendlin B, Mander B, Benca R. PMID: 38076899; PMCID: PMC10705699.
      View in: PubMed   Mentions:
    8. Medial temporal lobe functional network architecture supports sleep-related emotional memory processing in older adults. bioRxiv. 2023 Nov 01. Chappel-Farley MG, Adams JN, Betzel RF, Janecek JC, Sattari NS, Berisha DE, Meza NJ, Niknazar H, Kim S, Dave A, Chen IY, Lui KK, Neikrug AB, Benca RM, Yassa MA, Mander BA. PMID: 37961192; PMCID: PMC10634911.
      View in: PubMed   Mentions:
    9. Human REM sleep recalibrates neural activity in support of memory formation. Sci Adv. 2023 08 25; 9(34):eadj1895. Lendner JD, Niethard N, Mander BA, van Schalkwijk FJ, Schuh-Hofer S, Schmidt H, Knight RT, Born J, Walker MP, Lin JJ, Helfrich RF. PMID: 37624898; PMCID: PMC10456851.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. NREM sleep as a novel protective cognitive reserve factor in the face of Alzheimer's disease pathology. BMC Med. 2023 05 03; 21(1):156. Zavecz Z, Shah VD, Murillo OG, Vallat R, Mander BA, Winer JR, Jagust WJ, Walker MP. PMID: 37138290; PMCID: PMC10155344.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. High-Quality Sleep Mitigates ABCA7-Related Generalization Deficits in Healthy Older African Americans. J Alzheimers Dis. 2023; 94(1):281-290. Sinha N, Fausto BA, Mander B, Gluck MA. PMID: 37212111; PMCID: PMC10357211.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Self-reported sleep in relation to risk of dementia a quarter of a century later at age 90+: The 90+ Study. Behav Sleep Med. 2023 09 03; 21(5):620-632. Melikyan ZA, Kawas CH, Paganini-Hill A, Jiang L, Mander BA, Corrada MM. PMID: 37540023; PMCID: PMC10403699.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Inflammation, tau pathology, and synaptic integrity associated with sleep spindles and memory prior to β-amyloid positivity. Sleep. 2022 09 08; 45(9). Mander BA, Dave A, Lui KK, Sprecher KE, Berisha D, Chappel-Farley MG, Chen IY, Riedner BA, Heston M, Suridjan I, Kollmorgen G, Zetterberg H, Blennow K, Carlsson CM, Okonkwo OC, Asthana S, Johnson SC, Bendlin BB, Benca RM. PMID: 35670275; PMCID: PMC9758508.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    14. Symptoms of obstructive sleep apnea are associated with less frequent exercise and worse subjective cognitive function across adulthood. Sleep. 2022 03 14; 45(3). Chappel-Farley MG, Mander BA, Neikrug AB, Stehli A, Nan B, Grill JD, Yassa MA, Benca RM. PMID: 34604910; PMCID: PMC8919199.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Coupling between slow waves and sharp-wave ripples engages distributed neural activity during sleep in humans. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). Skelin I, Zhang H, Zheng J, Ma S, Mander BA, Kim McManus O, Vadera S, Knight RT, McNaughton BL, Lin JJ. PMID: 34001599; PMCID: PMC8166184.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    16. Aerobic fitness and the sleeping brain of adolescents-a pilot study. Sleep Adv. 2021; 2(1):zpab005. Neikrug AB, Mander BA, Radom-Aizik S, Chen IY, Stehli A, Lui KK, Chappel-Farley MG, Dave A, Benca RM. PMID: 33981996; PMCID: PMC8101484.
      View in: PubMed   Mentions:
    17. The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action. Front Pharmacol. 2020; 11:602590. Dudysová D, Janku K, Šmotek M, Saifutdinova E, Koprivová J, Bušková J, Mander BA, Brunovský M, Zach P, Korcák J, Andrashko V, Viktorinová M, Tylš F, Bravermanová A, Froese T, Pálenícek T, Horácek J. PMID: 33343372; PMCID: PMC7744693.
      View in: PubMed   Mentions: 4  
    18. Local Sleep and Alzheimer's Disease Pathophysiology. Front Neurosci. 2020; 14:525970. Mander BA. PMID: 33071726; PMCID: PMC7538792.
      View in: PubMed   Mentions: 30  
    19. Sleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent Years. Curr Biol. 2020 11 02; 30(21):4291-4298.e3. Winer JR, Mander BA, Kumar S, Reed M, Baker SL, Jagust WJ, Walker MP. PMID: 32888482; PMCID: PMC7642104.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    20. An electrophysiological marker of arousal level in humans. Elife. 2020 07 28; 9. Lendner JD, Helfrich RF, Mander BA, Romundstad L, Lin JJ, Walker MP, Larsson PG, Knight RT. PMID: 32720644; PMCID: PMC7394547.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    21. Objective measurement of sleep in mild cognitive impairment: A systematic review and meta-analysis. Sleep Med Rev. 2020 08; 52:101308. D'Rozario AL, Chapman JL, Phillips CL, Palmer JR, Hoyos CM, Mowszowski L, Duffy SL, Marshall NS, Benca R, Mander B, Grunstein RR, Naismith SL. PMID: 32302775.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    22. Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans. Nat Commun. 2019 08 08; 10(1):3572. Helfrich RF, Lendner JD, Mander BA, Guillen H, Paff M, Mnatsakanyan L, Vadera S, Walker MP, Lin JJ, Knight RT. PMID: 31395890; PMCID: PMC6687745.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    23. Sleep as a Potential Biomarker of Tau and β-Amyloid Burden in the Human Brain. J Neurosci. 2019 08 07; 39(32):6315-6324. Winer JR, Mander BA, Helfrich RF, Maass A, Harrison TM, Baker SL, Knight RT, Jagust WJ, Walker MP. PMID: 31209175; PMCID: PMC6687908.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    24. Multiplexing of Theta and Alpha Rhythms in the Amygdala-Hippocampal Circuit Supports Pattern Separation of Emotional Information. Neuron. 2019 05 22; 102(4):887-898.e5. Zheng J, Stevenson RF, Mander BA, Mnatsakanyan L, Hsu FPK, Vadera S, Knight RT, Yassa MA, Lin JJ. PMID: 30979537; PMCID: PMC6605056.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    25. Sleep, hippocampal volume, and cognition in adults over 90 years old. Aging Clin Exp Res. 2018 Nov; 30(11):1307-1318. Sabeti S, Al-Darsani Z, Mander BA, Corrada MM, Kawas CH. PMID: 30178444; PMCID: PMC6245552.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    26. Waking Up to the Importance of Sleep in the Pathogenesis of Alzheimer Disease. JAMA Neurol. 2018 06 01; 75(6):654-656. Winer JR, Mander BA. PMID: 29532083.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    27. Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting. Neuron. 2018 01 03; 97(1):221-230.e4. Helfrich RF, Mander BA, Jagust WJ, Knight RT, Walker MP. PMID: 29249289; PMCID: PMC5754239.
      View in: PubMed   Mentions: 164     Fields:    Translation:Humans
    28. White Matter Structure in Older Adults Moderates the Benefit of Sleep Spindles on Motor Memory Consolidation. J Neurosci. 2017 11 29; 37(48):11675-11687. Mander BA, Zhu AH, Lindquist JR, Villeneuve S, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP. PMID: 29084867; PMCID: PMC5707766.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    29. A restless night makes for a rising tide of amyloid. Brain. 2017 08 01; 140(8):2066-2069. Mander BA, Winer JR, Walker MP. PMID: 28899024.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. The sleep-deprived human brain. Nat Rev Neurosci. 2017 07; 18(7):404-418. Krause AJ, Simon EB, Mander BA, Greer SM, Saletin JM, Goldstein-Piekarski AN, Walker MP. PMID: 28515433; PMCID: PMC6143346.
      View in: PubMed   Mentions: 331     Fields:    Translation:Humans
    31. Sleep and Human Aging. Neuron. 2017 Apr 05; 94(1):19-36. Mander BA, Winer JR, Walker MP. PMID: 28384471; PMCID: PMC5810920.
      View in: PubMed   Mentions: 320     Fields:    Translation:Humans
    32. Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease? Trends Neurosci. 2016 08; 39(8):552-566. Mander BA, Winer JR, Jagust WJ, Walker MP. PMID: 27325209; PMCID: PMC4967375.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansAnimals
    33. β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation. Nat Neurosci. 2015 Jul; 18(7):1051-7. Mander BA, Marks SM, Vogel JW, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP. PMID: 26030850; PMCID: PMC4482795.
      View in: PubMed   Mentions: 210     Fields:    Translation:Humans
    34. Disturbed sleep in preclinical cognitive impairment: cause and effect? Sleep. 2013 Sep 01; 36(9):1275-6. Mander BA. PMID: 23997358; PMCID: PMC3738034.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    35. Impaired prefrontal sleep spindle regulation of hippocampal-dependent learning in older adults. Cereb Cortex. 2014 Dec; 24(12):3301-9. Mander BA, Rao V, Lu B, Saletin JM, Ancoli-Israel S, Jagust WJ, Walker MP. PMID: 23901074; PMCID: PMC4224242.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    36. Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging. Nat Neurosci. 2013 Mar; 16(3):357-64. Mander BA, Rao V, Lu B, Saletin JM, Lindquist JR, Ancoli-Israel S, Jagust W, Walker MP. PMID: 23354332; PMCID: PMC4286370.
      View in: PubMed   Mentions: 230     Fields:    Translation:Humans
    37. Concurrent impairments in sleep and memory in amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2012 May; 18(3):490-500. Westerberg CE, Mander BA, Florczak SM, Weintraub S, Mesulam MM, Zee PC, Paller KA. PMID: 22300710; PMCID: PMC3468412.
      View in: PubMed   Mentions: 127     Fields:    Translation:Humans
    38. Wake deterioration and sleep restoration of human learning. Curr Biol. 2011 Mar 08; 21(5):R183-4. Mander BA, Santhanam S, Saletin JM, Walker MP. PMID: 21377092; PMCID: PMC3093247.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    39. EEG measures index neural and cognitive recovery from sleep deprivation. J Neurosci. 2010 Feb 17; 30(7):2686-93. Mander BA, Reid KJ, Baron KG, Tjoa T, Parrish TB, Paller KA, Gitelman DR, Zee PC. PMID: 20164352; PMCID: PMC2835412.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    40. Sleep deprivation alters functioning within the neural network underlying the covert orienting of attention. Brain Res. 2008 Jun 27; 1217:148-56. Mander BA, Reid KJ, Davuluri VK, Small DM, Parrish TB, Mesulam MM, Zee PC, Gitelman DR. PMID: 18511023; PMCID: PMC2528837.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    41. Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus. Arch Intern Med. 2006 Sep 18; 166(16):1768-74. Knutson KL, Ryden AM, Mander BA, Van Cauter E. PMID: 16983057.
      View in: PubMed   Mentions: 238     Fields:    Translation:Humans
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