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Ira T Lott

Title(s)Recall Hcomp, Pediatrics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-5333
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    Biomarkers of Alzheimer's Disease in Adults with Down Syndrome
    NIH U01AG051412Sep 30, 2015 - Apr 30, 2021
    Role: Co-Principal Investigator
    Predicting Cognitive Decline in Adults with Down Syndrome
    NIH R01HD065160Sep 30, 2009 - Aug 31, 2015
    Role: Principal Investigator
    Alzheimer's Disease in Down Syndrome: Antioxidant Trial
    NIH R01AG021912Jun 1, 2003 - May 31, 2008
    Role: Principal Investigator
    UCI MRRC CENTER FOR MRDD DISORDERS OF PLASTICITY
    NIH P30HD028202Aug 31, 1995 - Jul 31, 2000
    Role: Principal Investigator
    Collapse Clinical Trials

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia. Acta Neuropathol. 2026 May 15; 151(1). Flores-Aguilar L, Zaikos TD, Rivera I, Wright ST, Lou J, Gawronski B, Gonzalez L, Berry JV, Rouanet J, Edwards NC, Hoang DK, Wood K, Granholm AC, Mufson EJ, Monuki ES, Ikonomovic MD, Kofler J, Doran EW, Lott IT, Totoiu MO, Hom CL, Lai F, Yong WH, Schmitt FA, Harp J, Nelson PT, Gutierrez J, Lao PJ, Wilcock DM, Brickman AM, Head E, Alzheimer’s Biomarker Consortium-Down syndrome (ABC-DS). PMID: 42141233; PMCID: PMC13179220.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. The association between APOE 𝜀4 carrierships and the detection of amyloid positivity using an Alzheimer's disease proteomic blood test in asymptomatic Down syndrome. Alzheimers Dement. 2026 Apr; 22(4):e71338. Abdullah LB, Zhang F, Petersen M, Hall J, Handen BL, Mapstone M, Christian B, Head E, Harley S, Andrews H, Lee JH, Tudorascu D, Hom C, Zaman S, Brickman AM, Rosas D, Cohen A, Harp JP, Schmitt F, Ptomey L, Burns JM, Lott IT, Lai F, Laymon C, Cruchaga C, O'Bryant S, Ances BM. PMID: 41964394; PMCID: PMC13069467.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan. Acta Neuropathol. 2026 Mar 22; 151(1). Pascual JR, Rivera I, Nguyen H, Ngo PT, Hoang A, Andrews EJ, Rouanet J, Wright ST, Sordo L, Kofler J, Ikonomovic MD, Lai F, Mapstone M, Christian BT, Handen BL, Lott IT, Doran E, Hom CL, Harp J, Schmitt F, Tudorascu DL, Ances BM, Phelan M, Liu L, Flores-Aguilar L, Head E, Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators. PMID: 41865347; PMCID: PMC13006465.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome. JAMA Neurol. 2026 Mar 01; 83(3):294-296. Russell JK, Schlachetzki Z, Ances BM, Rafii MS, Alzheimer’s Biomarker Consortium–Down Syndrome Study. PMID: 41525055; PMCID: PMC12797125.
      View in: PubMed   Mentions:    Fields:    
    5. The impact of congenital heart disease on the timing of Alzheimer's disease in Down syndrome. Alzheimers Dement (Amst). 2026 Jan-Mar; 18(1):e70257. Clina JG, Helsel BC, Hartley SL, White DA, Fleming-Batayneh VL, Handen B, Christian B, Head E, Mapstone M, Hom CL, Ances B, Burns J, Rosas HD, Lai F, McHale SK, Lee JH, Schmitt FA, Harp J, Lott IT, Zaman S, Ptomey LT, Alzheimer Biomarker Consortium–Down Syndrome (ABC-DS) Investigators. PMID: 41561734; PMCID: PMC12812862.
      View in: PubMed   Mentions:
    6. Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease. Alzheimers Dement. 2026 Jan; 22(1):e71103. Kennedy JT, Wisch JK, Boerwinkle AH, Millar PR, McKay NS, Brickman AM, Chhatwal JP, Mendez PC, Christian BT, Cohen A, Cruchaga C, Daniels A, Flores S, Handen BL, Hartley SL, Head E, Ibanez L, Krisnsky-McHale SJ, la Fougere C, Lai F, Laymon CM, Lee JH, Lee JH, Levin J, Llibre-Guerra J, Aguillon DF, Lott IT, Mapstone M, McDade E, Morris J, O'Bryant SE, Price JC, Rafii MS, Roh JH, Rosas HD, Schupf N, Supnet-Bell C, Xiong C, Zaman S, Benzinger TLS, Gordon BA, Ances BM, Alzheimer's Brain Consortium – Down Syndrome, and the Dominantly Inherited Alzheimer's Network. PMID: 41549404; PMCID: PMC12812856.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Imaging and plasma biomarkers for pathological accumulation in Down syndrome. Brain. 2025 Nov 05. Wisch JK, Jiao Z, Kennedy JT, Cohen AD, Schlachetzki Z, Petersen M, Handen BL, Christian BT, Mapstone M, Rosas HD, Lai F, Lee JH, Krinsky-McHale SJ, Schmitt FA, Harp JP, Hom C, Lott IT, Hartley S, Zaman S, Ptomey L, Burns JM, Tudorascu D, Ibanez L, Rafii MS, Head E, Ances BM. PMID: 41205623; PMCID: PMC12917769.
      View in: PubMed   Mentions:    Fields:    
    8. Neuropsychiatric symptoms and emerging dementia in people with Down syndrome and older adults. Alzheimers Dement. 2025 Nov; 21(11):e70871. Magana-Ramirez CM, Gillen DL, Hom CL, Jaimes L, Chilukuri SS, McMahon N, Lin C, Kuhlman R, Hu T, Head E, Lott IT, Sultzer DL. PMID: 41207870; PMCID: PMC12597398.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome. Alzheimers Dement. 2025 Oct; 21(10):e70726. Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Flores-Aguilar L, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators, Gutierrez J, Wilcock DM, Head E, Brickman AM. PMID: 41014048; PMCID: PMC12475832.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Alzheimer's Disease Research Center Down Syndrome Cores: Experience from two sites. Alzheimers Dement. 2025 08; 21(8):e70612. Ptomey L, Hom C, Wilkins H, Doran E, Wright ST, Hoang D, Delehoy B, Lott IT, Perales-Puchalt J, Helsel B, Burns J, Grill JD, Head E. PMID: 40847661; PMCID: PMC12374163.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study. Lancet Neurol. 2025 Jul; 24(7):591-600. Janelidze S, Collij LE, Mattsson-Carlgren N, Antill A, Laymon CM, Lott I, Rosas HD, Minhas DS, Luo W, Zaman S, Alzheimer's Biomarker Consortium–Down Syndrome investigators, Mapstone M, Head E, Lai F, Hartley SL, Ances BM, Krinsky-McHale SJ, Lee JH, Ossenkoppele R, Christian BT, Handen BL, Hansson O. PMID: 40541209; PMCID: PMC12174012.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross-sectional associations with early cognitive impairments. Alzheimers Dement. 2025 07; 21(7):e70424. Fu JF, Garimella A, Lapointe A, Aye WWT, Chen CD, Lee JH, Krinsky-McHale SJ, Zaman S, Lott IT, Hom C, Ances B, Head E, Mapstone M, Lai F, Handen BL, Laymon CM, Hartley SL, Christian BT, Rentz DM, Johnson KA, Rosas HD, Price JC, Alzheimer Biomarkers Consortium–Down Syndrome (ABC-DS). PMID: 40588723; PMCID: PMC12208798.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Longitudinal study of body mass index in relation to Alzheimer's disease pathology and symptomatology in Down syndrome. Alzheimers Dement. 2025 06; 21(6):e70387. Fleming VL, Helsel BC, Ptomey LT, Handen BL, Krinsky-McHale SJ, Hom CL, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Brickman AM, Pulsifer M, Clare ICH, Rosa HD, Lai F, Harp J, Schmitt F, Price J, Zaman SH, Head E, Mapstone M, Christian BT, Okonkwo O, Hartley SL, Alzheimer's Biomarkers Consortium–Down Syndrome. PMID: 40545561; PMCID: PMC12183108.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. The history of Down syndrome-associated Alzheimer's disease; past, present, and future. Alzheimers Dement. 2025 06; 21(6):e70158. Maure-Blesa L, Carmona-Iragui M, Lott I, Head E, Wisniewski T, Rafii MS, Espinosa J, Flórez J, Mobley WC, Holland A, Strydom A, Zaman S, Fortea J. PMID: 40469048; PMCID: PMC12138279.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. Cognitive and Behavioural Associations of Visual and Hearing Impairments Across the Lifespan in People With Down Syndrome, a Scoping Review. J Intellect Disabil Res. 2025 09; 69(9):753-780. Betoni NJ, Okamoto CM, Lott IT, Hom CL. PMID: 40377220; PMCID: PMC12418728.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. The Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS): A 10-year report. Alzheimers Dement. 2025 05; 21(5):e70294. Handen BL, Mapstone M, Hartley S, Andrews H, Christian B, Lee JH, Tudorascu D, Hom C, Ances BM, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Petersen M, O'Bryant S, Harp JP, Schmitt F, Ptomey L, Burns J, Lott IT, Lai F, Silverman W, Laymon C, Head E, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 40371686; PMCID: PMC12079517.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer's disease and related neurodegenerative pathologies using 7T postmortem MRI. J Neuropathol Exp Neurol. 2025 May 01; 84(5):364-378. Liou JJ, Li J, Berardinelli J, Jin H, Santini T, Noh J, Farhat N, Wu M, Aizenstein HJ, Mettenburg JM, Yong WH, Head E, Ikonomovic MD, Ibrahim TS, Kofler JK, Alzheimer Biomarker Consortium—Down Syndrome . PMID: 40063697; PMCID: PMC12012357.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Behavioral and psychological symptoms of dementia and Alzheimer's disease progression in Down syndrome. J Neurodev Disord. 2025 Apr 11; 17(1):19. Jenkins MR, Peven JC, Kubic L, Handen BL, Krinsky-McHale SJ, Hom CL, Lee A, Tudorascu DL, McLachlan M, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Rosas HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL, Alzheimer Biomarker Consortium - Down syndrome. PMID: 40217501; PMCID: PMC11987311.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Longitudinal investigation of gait and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement. 2025 04; 21(4):e70211. Barry A, Peven JC, Handen BL, Bolt D, Krinsky-McHale SJ, Hom CL, Clare ICH, Glueck A, Harp J, Schmitt F, Zammit M, Minhas D, Luo W, Laymon C, Price J, Lee JH, Lott I, Cohen A, Ances BM, Pulsifer M, Rosa HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL, Alzheimer Biomarker Consortium - Down syndrome. PMID: 40289844; PMCID: PMC12035545.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. A neuropathology case report of a woman with Down syndrome who remained cognitively stable: Implications for resilience to neuropathology. Alzheimers Dement. 2025 02; 21(2):e14479. Liou JJ, Lou J, Flores-Aguilar L, Nakagiri J, Yong W, Hom CL, Doran EW, Totoiu MO, Lott I, Mapstone M, Keator DB, Brickman AM, Wright ST, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E, Alzheimer Biomarker Consortium - Down Syndrome. PMID: 39868632; PMCID: PMC11851131.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    21. Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study. Lancet Neurol. 2024 12; 23(12):1214-1224. Schworer EK, Zammit MD, Wang J, Handen BL, Betthauser T, Laymon CM, Tudorascu DL, Cohen AD, Zaman SH, Ances BM, Mapstone M, Head E, Christian BT, Hartley SL, Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS). PMID: 39577922; PMCID: PMC12207984.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    22. Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's disease. Nat Genet. 2024 Dec; 56(12):2704-2717. Miyoshi E, Morabito S, Henningfield CM, Das S, Rahimzadeh N, Shabestari SK, Michael N, Emerson N, Reese F, Shi Z, Cao Z, Srinivasan SS, Scarfone VM, Arreola MA, Lu J, Wright S, Silva J, Leavy K, Lott IT, Doran E, Yong WH, Shahin S, Perez-Rosendahl M, Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC–DS), Head E, Green KN, Swarup V. PMID: 39578645; PMCID: PMC11631771.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    23. The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down's syndrome. Alzheimers Dement. 2025 01; 21(1):e14359. Boerwinkle AH, Wisch JK, Handen BL, Head E, Mapstone M, Rafii MS, O'Bryant SE, Krinsky-McHale SJ, Lai F, Rosas HD, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Ances BM, Alzheimer's Biomarker Consortium-Down Syndrome. PMID: 39535359; PMCID: PMC11782213.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome. EBioMedicine. 2024 Dec; 110:105433. Xicota L, Dang LT, Lee A, Krinsky-McHale S, Pang D, Melilli L, O'Bryant S, Henson RL, Laymon C, Lai F, Rosas HD, Ances B, Lott I, Hom C, Christian B, Hartley S, Zaman S, Head E, Mapstone M, Jin Z, Silverman W, Schupf N, Handen B, Lee JH, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 39500037; PMCID: PMC11570228.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome. JAMA Neurol. 2024 Oct 01; 81(10):1066-1072. Liu L, Saba A, Pascual JR, Miller MB, Hennessey EL, Lott IT, Brickman AM, Wilcock DM, Harp JP, Schmitt FA, Selkoe DJ, Chhatwal JP, Head E. PMID: 39158850; PMCID: PMC11334015.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    26. Cerebrovascular disease is associated with Alzheimer's plasma biomarker concentrations in adults with Down syndrome. Brain Commun. 2024; 6(5):fcae331. Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Aguilar LF, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA, Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators , Gutierrez J, Wilcock DM, Head E, Brickman AM. PMID: 39403075; PMCID: PMC11472828.
      View in: PubMed   Mentions: 19  
    27. Comparing research attitudes in Down syndrome and non-Down syndrome research decision-makers. Alzheimers Dement (N Y). 2024 Jul-Sep; 10(3):e12478. Lu TV, Campos P, Leader S, Lee X, Xu H, Doran E, Grill JD, Lott IT. PMID: 39086735; PMCID: PMC11289724.
      View in: PubMed   Mentions: 2  
    28. A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable. medRxiv. 2024 Jun 03. Liou JJ, Lou J, Nakagiri J, Yong W, Hom CL, Doran EW, Totoiu M, Lott I, Mapstone M, Keator DB, Brickman AM, Wright S, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E, Alzheimer Biomarker Consortium - Down Syndrome. PMID: 38883742; PMCID: PMC11177914.
      View in: PubMed   Mentions:
    29. A pathway linking pulse pressure to dementia in adults with Down syndrome. Brain Commun. 2024; 6(3):fcae157. Rizvi B, Lao PJ, Sathishkumar M, Taylor L, Queder N, McMillan L, Edwards NC, Keator DB, Doran E, Hom C, Nguyen D, Rosas HD, Lai F, Schupf N, Gutierrez J, Silverman W, Lott IT, Mapstone M, Wilcock DM, Head E, Yassa MA, Brickman AM. PMID: 38764776; PMCID: PMC11099660.
      View in: PubMed   Mentions: 1  
    30. Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study. Lancet Neurol. 2024 05; 23(5):500-510. Wisch JK, McKay NS, Boerwinkle AH, Kennedy J, Flores S, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant SE, Price JC, Laymon CM, Krinsky-McHale SJ, Lai F, Rosas HD, Hartley SL, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Bird TD, Cohen A, Chrem P, Daniels A, Chhatwal JP, Cruchaga C, Ibanez L, Jucker M, Karch CM, Day GS, Lee JH, Levin J, Llibre-Guerra J, Li Y, Lopera F, Roh JH, Ringman JM, Supnet-Bell C, van Dyck CH, Xiong C, Wang G, Morris JC, McDade E, Bateman RJ, Benzinger TLS, Gordon BA, Ances BM, Alzheimer's Biomarker Consortium-Down syndrome, Dominantly Inherited Alzheimer Network. PMID: 38631766; PMCID: PMC11209765.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    31. Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome. Alzheimers Dement (Amst). 2024 Apr-Jun; 16(2):e12582. Schworer EK, Handen BL, Petersen M, O'Bryant S, Peven JC, Tudorascu DL, Lee L, Krinsky-McHale SJ, Hom CL, Clare ICH, Christian BT, Schupf N, Lee JH, Head E, Mapstone M, Lott I, Ances BM, Zaman S, Brickman AM, Lai F, Rosas HD, Hartley SL, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 38623384; PMCID: PMC11016818.
      View in: PubMed   Mentions: 15  
    32. Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease. Alzheimers Dement. 2024 04; 20(4):2670-2679. Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S, Long-Life Family Study (LLFS), Alzheimer's Disease Genetic Consortium (ADGC), Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS). PMID: 38380866; PMCID: PMC11032545.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    33. Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome. Alzheimers Dement (Amst). 2024 Jan-Mar; 16(1):e12542. DiProspero N, Sathishkumar M, Janecek J, Smith A, McMillan L, Petersen M, Tustison N, Keator DB, Doran E, Hom CL, Nguyen D, Andrews H, Krinsky-McHale S, Brickman AM, Rosas HD, Lai F, Head E, Mapstone M, Silverman W, Lott IT, O'Bryant S, Yassa MA. PMID: 38348178; PMCID: PMC10859879.
      View in: PubMed   Mentions: 6  
    34. Insomnia Symptoms Are Associated with Measures of Functional Deterioration and Dementia Status in Adults with Down Syndrome at High Risk for Alzheimer's Disease. J Alzheimers Dis. 2024; 100(2):613-629. Desai S, Chen IY, Hom C, Doran E, Nguyen DD, Benca RM, Lott IT, Mander BA. PMID: 38875029; PMCID: PMC11307085.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome. medRxiv. 2023 Nov 30. Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Flores-Aguilar L, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA, Gutierrez J, Wilcock DM, Head E, Brickman AM. PMID: 38076904; PMCID: PMC10705616.
      View in: PubMed   Mentions:
    36. Pathways linking pulse pressure to dementia in adults with Down syndrome. medRxiv. 2023 Oct 26. Rizvi B, Lao PJ, Sathishkumar M, Taylor L, Queder N, McMillan L, Edwards N, Keator DB, Doran E, Hom C, Nguyen D, Rosas HD, Lai F, Schupf N, Gutierrez J, Silverman W, Lott IT, Mapstone M, Wilcock DM, Head E, Yassa MA, Brickman AM. PMID: 37961444; PMCID: PMC10635215.
      View in: PubMed   Mentions:
    37. Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease. bioRxiv. 2023 Jul 26. Miyoshi E, Morabito S, Henningfield CM, Rahimzadeh N, Kiani Shabestari S, Das S, Michael N, Reese F, Shi Z, Cao Z, Scarfone V, Arreola MA, Lu J, Wright S, Silva J, Leavy K, Lott IT, Doran E, Yong WH, Shahin S, Perez-Rosendahl M, Head E, Green KN, Swarup V. PMID: 37546983; PMCID: PMC10402031.
      View in: PubMed   Mentions:
    38. Increased plasma DYRK1A with aging may protect against neurodegenerative diseases. Transl Psychiatry. 2023 04 04; 13(1):111. Delabar JM, Lagarde J, Fructuoso M, Mohammad A, Bottlaender M, Doran E, Lott I, Rivals I, Schmitt FA, Head E, Sarazin M, Potier MC. PMID: 37015911; PMCID: PMC10073199.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    39. Research attitudes in families of individuals with Down syndrome: importance for clinical trials. Alzheimers Res Ther. 2022 11 23; 14(1):176. Lott IT, Kirby KA, Doran E, Grill JD. PMID: 36419175; PMCID: PMC9686118.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    40. A modified Cued Recall Test for detecting prodromal AD in adults with Down syndrome. Alzheimers Dement (Amst). 2022; 14(1):e12361. Krinsky-McHale SJ, Hartley S, Hom C, Pulsifer M, Clare ICH, Handen BL, Lott IT, Schupf N, Silverman W, Alzheimer's Biomarker Consortium—Down Syndrome (ABC-DS) Investigators. PMID: 36212742; PMCID: PMC9527593.
      View in: PubMed   Mentions: 20  
    41. Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers. JAMA Neurol. 2022 08 01; 79(8):797-807. Janelidze S, Christian BT, Price J, Laymon C, Schupf N, Klunk WE, Lott I, Silverman W, Rosas HD, Zaman S, Mapstone M, Lai F, Ances BM, Handen BL, Hansson O. PMID: 35789365; PMCID: PMC9257682.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    42. Correction: Hom et al. Cognitive Function during the Prodromal Stage of Alzheimer's Disease in Down Syndrome: Comparing Models. BrainSci. 2021, 11, 1220. Brain Sci. 2022 Jul 15; 12(7). Hom CL, Kirby KA, Ricks-Oddie J, Keator DB, Krinsky-McHale SJ, Pulsifer MB, Rosas HD, Lai F, Schupf N, Lott IT, Silverman W. PMID: 35884766; PMCID: PMC9313374.
      View in: PubMed   Mentions:
    43. Joint-label fusion brain atlases for dementia research in Down syndrome. Alzheimers Dement (Amst). 2022; 14(1):e12324. Queder N, Phelan MJ, Taylor L, Tustison N, Doran E, Hom C, Nguyen D, Lai F, Pulsifer M, Price J, Kreisl WC, Rosas HD, Krinsky-McHale S, Brickman AM, Yassa MA, Schupf N, Silverman W, Lott IT, Head E, Mapstone M, Keator DB, Alzheimer's Biomarkers Consortium. PMID: 35634535; PMCID: PMC9131930.
      View in: PubMed   Mentions: 5  
    44. Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer's continuum. Sleep Adv. 2022; 3(1):zpac013. Lao P, Zimmerman ME, Hartley SL, Gutierrez J, Keator D, Igwe KC, Laing KK, Cotton-Samuel D, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Diana Rosas H, Silverman W, Lott IT, Schupf N, Brickman AM. PMID: 35669316; PMCID: PMC9154738.
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    45. Probing the proteome to explore potential correlates of increased Alzheimer's-related cerebrovascular disease in adults with Down syndrome. Alzheimers Dement. 2022 10; 18(10):1744-1753. Moni F, Petersen ME, Zhang F, Lao PJ, Zimmerman ME, Gu Y, Gutierrez J, Rizvi B, Laing KK, Igwe KC, Sathishkumar M, Keator D, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, O'Bryant S, Brickman AM. PMID: 35212182; PMCID: PMC9399305.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    46. Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome. Disabil Health J. 2022 07; 15(3):101278. Hartley SL, Fleming V, Piro-Gambetti B, Cohen A, Ances BM, Yassa MA, Brickman AM, Handen BL, Head E, Mapstone M, Christian BT, Lott IT, Doran E, Zaman S, Krinsky-McHale S, Schmitt FA, Hom C, Schupf N, ABC-DS Group. PMID: 35256308; PMCID: PMC8849846.
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    47. Primitive Reflexes and Dementia in Adults With Down Syndrome. Neurol Clin Pract. 2022 Feb; 12(1):6-13. Harp J, Koehl L, Van Pelt K, Head E, Jicha G, Robertson W, Lightner D, Lott I, Schmitt F. PMID: 36157622; PMCID: PMC9491499.
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    48. Selective Impairment of Long-Range Default Mode Network Functional Connectivity as a Biomarker for Preclinical Alzheimer's Disease in People with Down Syndrome. J Alzheimers Dis. 2022; 85(1):153-165. DiProspero ND, Keator DB, Phelan M, van Erp TGM, Doran E, Powell DK, Van Pelt KL, Schmitt FA, Head E, Lott IT, Yassa MA. PMID: 34776436; PMCID: PMC9017677.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    49. Cognitive Function during the Prodromal Stage of Alzheimer's Disease in Down Syndrome: Comparing Models. Brain Sci. 2021 Sep 16; 11(9). Hom CL, Kirby KA, Ricks-Oddie J, Keator DB, Krinsky-McHale SJ, Pulsifer MB, Rosas HD, Lai F, Schupf N, Lott IT, Silverman W. PMID: 34573242; PMCID: PMC8471085.
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    50. Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome. Brain Sci. 2021 Aug 25; 11(9). Harp JP, Koehl LM, Pelt KLV, Hom CL, Doran E, Head E, Lott IT, Schmitt FA. PMID: 34573150; PMCID: PMC8468129.
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    51. Postmortem Neocortical 3H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer's Disease. Front Aging Neurosci. 2021; 13:728739. Pivtoraiko VN, Racic T, Abrahamson EE, Villemagne VL, Handen BL, Lott IT, Head E, Ikonomovic MD. PMID: 34489686; PMCID: PMC8416541.
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    52. Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study. Lancet Neurol. 2021 08; 20(8):615-626. Fagan AM, Henson RL, Li Y, Boerwinkle AH, Xiong C, Bateman RJ, Goate A, Ances BM, Doran E, Christian BT, Lai F, Rosas HD, Schupf N, Krinsky-McHale S, Silverman W, Lee JH, Klunk WE, Handen BL, Allegri RF, Chhatwal JP, Day GS, Graff-Radford NR, Jucker M, Levin J, Martins RN, Masters CL, Mori H, Mummery CJ, Niimi Y, Ringman JM, Salloway S, Schofield PR, Shoji M, Lott IT, Alzheimer's Biomarker Consortium–Down Syndrome, Dominantly Inherited Alzheimer Network. PMID: 34302786; PMCID: PMC8496347.
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    53. A unique case of progressive hemifacial microsomia or Parry-Romberg syndrome associated with limb and brain anomalies with normal neurological findings: A review of the literature. Eur J Med Genet. 2021 Sep; 64(9):104234. Pattnaik A, Lim A, Sabeti S, Kwon A, Hall K, Lott I, Kimonis V. PMID: 34082156.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    54. Altered connectivity of the default mode network in cognitively stable adults with Down syndrome: "Accelerated aging" or a prelude to Alzheimer's disease? Alzheimers Dement (Amst). 2021; 13(1):e12105. Rosas HD, Lewis LR, Mercaldo ND, Nasr S, Brickman AM, Siless V, Yassa M, Sathishkumar M, Lott I, Schupf N, Silverman W, Lai F, Alzheimer's Disease in Down Syndrome (ADDS) Consortium. PMID: 34027014; PMCID: PMC8136300.
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    55. Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. J Clin Med. 2021 Apr 28; 10(9). Hendrix JA, Airey DC, Britton A, Burke AD, Capone GT, Chavez R, Chen J, Chicoine B, Costa ACS, Dage JL, Doran E, Esbensen A, Evans CL, Faber KM, Foroud TM, Hart S, Haugen K, Head E, Hendrix S, Hillerstrom H, Kishnani PS, Krell K, Ledesma DL, Lai F, Lott I, Ochoa-Lubinoff C, Mason J, Nicodemus-Johnson J, Proctor NK, Pulsifer MB, Revta C, Rosas HD, Rosser TC, Santoro S, Schafer K, Scheidemantel T, Schmitt F, Skotko BG, Stasko MR, Talboy A, Torres A, Wilmes K, Woodward J, Zimmer JA, Feldman HH, Mobley W. PMID: 33924960; PMCID: PMC8124643.
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    56. Development of a symptom menu to facilitate Goal Attainment Scaling in adults with Down syndrome-associated Alzheimer's disease: a qualitative study to identify meaningful symptoms. J Patient Rep Outcomes. 2021 Jan 11; 5(1):5. Knox K, Stanley J, Hendrix JA, Hillerstrom H, Dunn T, Achenbach J, Chicoine BA, Lai F, Lott I, Stanojevic S, Howlett SE, Rockwood K. PMID: 33427993; PMCID: PMC7801557.
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    57. Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. J Alzheimers Dis. 2021; 79(2):671-681. Petersen ME, Rafii MS, Zhang F, Hall J, Julovich D, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Foroud T, Lai F, Diana Rosas H, Zaman S, Wang MC, Tycko B, Lee JH, Handen B, Hartley S, Fortea J, O'Bryant S, Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS). PMID: 33337378; PMCID: PMC8273927.
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    58. Evaluation of the National Task Group-Early Detection Screen for Dementia: Sensitivity to 'mild cognitive impairment' in adults with Down syndrome. J Appl Res Intellect Disabil. 2021 May; 34(3):905-915. Silverman W, Krinsky-McHale SJ, Lai F, Diana Rosas H, Hom C, Doran E, Pulsifer M, Lott I, Schupf N, Alzheimer’s Disease in Down Syndrome (ADDS) Consortium. PMID: 33314467; PMCID: PMC8356176.
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    59. Brain amyloid and the transition to dementia in Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12126. Keator DB, Doran E, Taylor L, Phelan MJ, Hom C, Tseung K, van Erp TGM, Potkin SG, Brickman AM, Rosas DH, Yassa MA, Silverman W, Lott IT. PMID: 33204814; PMCID: PMC7656170.
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    60. Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD? Alzheimers Dement (Amst). 2020; 12(1):e12040. Rosas HD, Hsu E, Mercaldo ND, Lai F, Pulsifer M, Keator D, Brickman AM, Price J, Yassa M, Hom C, Krinsky-McHale SJ, Silverman W, Lott I, Schupf N. PMID: 33204811; PMCID: PMC7648416.
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    61. The AT(N) framework for Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12062. Rafii MS, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Lai F, Rosas HD, Zaman S, Petersen ME, Strydom A, Fortea J, Handen B, O'Bryant S. PMID: 33134477; PMCID: PMC7588820.
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    62. Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12113. Martini AC, Helman AM, McCarty KL, Lott IT, Doran E, Schmitt FA, Head E. PMID: 33088896; PMCID: PMC7560512.
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    63. Alzheimer-Related Cerebrovascular Disease in Down Syndrome. Ann Neurol. 2020 12; 88(6):1165-1177. Lao PJ, Gutierrez J, Keator D, Rizvi B, Banerjee A, Igwe KC, Laing KK, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, Brickman AM. PMID: 32944999; PMCID: PMC7729262.
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    64. Language skills as a predictor of cognitive decline in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12080. Pulsifer MB, Evans CL, Hom C, Krinsky-McHale SJ, Silverman W, Lai F, Lott I, Schupf N, Wen J, Rosas HD. PMID: 32875055; PMCID: PMC7447889.
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    65. The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimers Dement (Amst). 2020; 12(1):e12065. Handen BL, Lott IT, Christian BT, Schupf N, OBryant S, Mapstone M, Fagan AM, Lee JH, Tudorascu D, Wang MC, Head E, Klunk W, Ances B, Lai F, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Andrews H, Hartley S, Silverman W, Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS). PMID: 32775597; PMCID: PMC7396809.
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    66. Cerebrospinal fluid biomarkers of Alzheimer's disease in a cohort of adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12057. Henson RL, Doran E, Christian BT, Handen BL, Klunk WE, Lai F, Lee JH, Rosas HD, Schupf N, Zaman SH, Lott IT, Fagan AM. PMID: 32671183; PMCID: PMC7346867.
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    67. Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study. Alzheimers Dement (Amst). 2020; 12(1):e12039. Petersen ME, Zhang F, Schupf N, Krinsky-McHale SJ, Hall J, Mapstone M, Cheema A, Silverman W, Lott I, Rafii MS, Handen B, Klunk W, Head E, Christian B, Foroud T, Lai F, Rosas HD, Zaman S, Ances BM, Wang MC, Tycko B, Lee JH, O'Bryant S, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 32626817; PMCID: PMC7327223.
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    68. Down syndrome: Distribution of brain amyloid in mild cognitive impairment. Alzheimers Dement (Amst). 2020; 12(1):e12013. Keator DB, Phelan MJ, Taylor L, Doran E, Krinsky-McHale S, Price J, Ballard EE, Kreisl WC, Hom C, Nguyen D, Pulsifer M, Lai F, Rosas DH, Brickman AM, Schupf N, Yassa MA, Silverman W, Lott IT. PMID: 32435685; PMCID: PMC7233421.
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    69. Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12028. Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators. PMID: 32258359; PMCID: PMC7131985.
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    70. Characterising the brain metalloproteome in Down syndrome patients with concomitant Alzheimer's pathology. Metallomics. 2020 01 29; 12(1):114-132. Malakooti N, Roberts B, Pritchard MA, Volitakis I, Kim RC, Lott IT, McLean CA, Finkelstein DI, Adlard PA. PMID: 31764918.
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    71. Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review. J Neurodev Disord. 2019 08 30; 11(1):20. Hamburg S, Lowe B, Startin CM, Padilla C, Coppus A, Silverman W, Fortea J, Zaman S, Head E, Handen BL, Lott I, Song W, Strydom A. PMID: 31470792; PMCID: PMC6716931.
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    72. Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease. Dev Neurobiol. 2019 07; 79(7):622-638. Gross TJ, Doran E, Cheema AK, Head E, Lott IT, Mapstone M. PMID: 31419370.
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    73. Neuropathological correlates of amyloid PET imaging in Down syndrome. Dev Neurobiol. 2019 07; 79(7):750-766. Abrahamson EE, Head E, Lott IT, Handen BL, Mufson EJ, Christian BT, Klunk WE, Ikonomovic MD. PMID: 31379087; PMCID: PMC6892598.
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    74. Dementia in Down syndrome: unique insights for Alzheimer disease research. Nat Rev Neurol. 2019 03; 15(3):135-147. Lott IT, Head E. PMID: 30733618; PMCID: PMC8061428.
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    75. Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia. Acta Neuropathol. 2019 03; 137(3):413-436. Perez SE, Miguel JC, He B, Malek-Ahmadi M, Abrahamson EE, Ikonomovic MD, Lott I, Doran E, Alldred MJ, Ginsberg SD, Mufson EJ. PMID: 30734106; PMCID: PMC6541490.
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    76. Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease. J Alzheimers Dis. 2019; 67(1):103-112. Helman AM, Siever M, McCarty KL, Lott IT, Doran E, Abner EL, Schmitt FA, Head E. PMID: 30452414; PMCID: PMC6424116.
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    77. Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease. Cell Rep. 2018 06 05; 23(10):2967-2975. Miranda AM, Herman M, Cheng R, Nahmani E, Barrett G, Micevska E, Fontaine G, Potier MC, Head E, Schmitt FA, Lott IT, Jiménez-Velázquez IZ, Antonarakis SE, Di Paolo G, Lee JH, Hussaini SA, Marquer C. PMID: 29874583; PMCID: PMC6040810.
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    78. Cerebrovascular pathology in Down syndrome and Alzheimer disease. Acta Neuropathol Commun. 2017 Dec 01; 5(1):93. Head E, Phelan MJ, Doran E, Kim RC, Poon WW, Schmitt FA, Lott IT. PMID: 29195510; PMCID: PMC5709935.
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    79. Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan. Neurobiol Aging. 2017 06; 54:163-169. LeVine H, Spielmann HP, Matveev S, Cauvi FM, Murphy MP, Beckett TL, McCarty K, Lott IT, Doran E, Schmitt F, Head E. PMID: 28385551; PMCID: PMC5638297.
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    80. Metabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate Between Down Syndrome and Alzheimer's Disease. J Alzheimers Dis. 2017; 55(2):737-748. Coskun P, Helguera P, Nemati Z, Bohannan RC, Thomas J, Samuel SE, Argueta J, Doran E, Wallace DC, Lott IT, Busciglio J. PMID: 27802222.
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    81. Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP. J Alzheimers Dis. 2017; 56(2):459-470. Doran E, Keator D, Head E, Phelan MJ, Kim R, Totoiu M, Barrio JR, Small GW, Potkin SG, Lott IT. PMID: 27983553; PMCID: PMC5662115.
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    82. A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Oral ELND005 (scyllo-Inositol) in Young Adults with Down Syndrome without Dementia. J Alzheimers Dis. 2017; 58(2):401-411. Rafii MS, Skotko BG, McDonough ME, Pulsifer M, Evans C, Doran E, Muranevici G, Kesslak P, Abushakra S, Lott IT, ELND005-DS Study Group. PMID: 28453471; PMCID: PMC5777855.
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    83. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome. Alzheimers Dement. 2017 May; 13(5):541-549. Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona-Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, Granholm AC. PMID: 27755974; PMCID: PMC5812672.
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    84. Cognitive Profiles on the Severe Impairment Battery Are Similar in Alzheimer Disease and Down Syndrome With Dementia. Alzheimer Dis Assoc Disord. 2016 Jul-Sep; 30(3):251-7. Dick MB, Doran E, Phelan M, Lott IT. PMID: 26704220; PMCID: PMC5860802.
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    85. Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms. Brain Cogn. 2016 Apr; 104:48-57. Anderson-Mooney AJ, Schmitt FA, Head E, Lott IT, Heilman KM. PMID: 26930369; PMCID: PMC4801771.
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    86. Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology. Curr Alzheimer Res. 2016; 13(1):18-29. Head E, Lott IT, Wilcock DM, Lemere CA. PMID: 26651341; PMCID: PMC4948181.
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    87. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimers Dement. 2015 Jun; 11(6):700-9. Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T. PMID: 25510383; PMCID: PMC4817997.
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    88. Self-concept in children with Down syndrome. Am J Med Genet A. 2014 Aug; 164A(8):1891-8. Saha S, Doran E, Osann KE, Hom C, Movsesyan N, Rosa DD, Tournay A, Lott IT. PMID: 24838927; PMCID: PMC5800412.
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    89. Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease. J Alzheimers Dis. 2014; 42(3):767-75. Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E. PMID: 24927707; PMCID: PMC4392817.
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    90. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. Brain. 2013 Oct; 136(Pt 10):3018-27. Sanchez-Mut JV, Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio RG, Fernandez AF, Astudillo A, Martin-Subero JI, Balint B, Fraga MF, Gomez A, Gurnot C, Roux JC, Avila J, Hensch TK, Ferrer I, Esteller M. PMID: 24030951; PMCID: PMC3784285.
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    91. Aging and down syndrome. Curr Gerontol Geriatr Res. 2012; 2012:412536. Head E, Silverman W, Patterson D, Lott IT. PMID: 22844278; PMCID: PMC3400297.
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    92. Down syndrome and dementia: seizures and cognitive decline. J Alzheimers Dis. 2012; 29(1):177-85. Lott IT, Doran E, Nguyen VQ, Tournay A, Movsesyan N, Gillen DL. PMID: 22214782; PMCID: PMC3406603.
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    93. Neurological phenotypes for Down syndrome across the life span. Prog Brain Res. 2012; 197:101-21. Lott IT. PMID: 22541290; PMCID: PMC3417824.
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    94. Antioxidants in Down syndrome. Biochim Biophys Acta. 2012 May; 1822(5):657-63. Lott IT. PMID: 22206998; PMCID: PMC3408054.
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    95. Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochim Biophys Acta. 2012 Feb; 1822(2):130-8. Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H, Lott IT, Schmitt FA, Butterfield DA, Head E. PMID: 22009041; PMCID: PMC3260028.
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    96. Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation. Am J Med Genet A. 2011 Aug; 155A(8):1939-48. Lott IT, Doran E, Nguyen VQ, Tournay A, Head E, Gillen DL. PMID: 21739598; PMCID: PMC3410645.
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    97. Altered brain dynamics during voluntary movement in individuals with Down syndrome. Neuroreport. 2011 May 11; 22(7):358-64. Virji-Babul N, Moiseev A, Moiseeva N, Sun W, Ribary U, Lott I. PMID: 21464774.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    98. Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. J Alzheimers Dis. 2011; 23(3):399-409. Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT. PMID: 21116050; PMCID: PMC3219221.
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    99. Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10-17. Am J Med Genet A. 2010 Dec; 152A(12):3028-35. Kishnani PS, Heller JH, Spiridigliozzi GA, Lott I, Escobar L, Richardson S, Zhang R, McRae T. PMID: 21108390.
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    100. Down syndrome: from understanding the neurobiology to therapy. J Neurosci. 2010 Nov 10; 30(45):14943-5. Gardiner K, Herault Y, Lott IT, Antonarakis SE, Reeves RH, Dierssen M. PMID: 21068296; PMCID: PMC3842485.
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    101. Cognitive deficits and associated neurological complications in individuals with Down's syndrome. Lancet Neurol. 2010 Jun; 9(6):623-33. Lott IT, Dierssen M. PMID: 20494326.
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    102. Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis. 2010; 20 Suppl 2:S293-310. Coskun PE, Wyrembak J, Derbereva O, Melkonian G, Doran E, Lott IT, Head E, Cotman CW, Wallace DC. PMID: 20463402; PMCID: PMC4175722.
      View in: PubMed   Mentions: 92     Fields:    Translation:Humans
    103. The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12031-6. Korbel JO, Tirosh-Wagner T, Urban AE, Chen XN, Kasowski M, Dai L, Grubert F, Erdman C, Gao MC, Lange K, Sobel EM, Barlow GM, Aylsworth AS, Carpenter NJ, Clark RD, Cohen MY, Doran E, Falik-Zaccai T, Lewin SO, Lott IT, McGillivray BC, Moeschler JB, Pettenati MJ, Pueschel SM, Rao KW, Shaffer LG, Shohat M, Van Riper AJ, Warburton D, Weissman S, Gerstein MB, Snyder M, Korenberg JR. PMID: 19597142; PMCID: PMC2709665.
      View in: PubMed   Mentions: 205     Fields:    Translation:HumansCells
    104. A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta Neuropathol. 2009 Oct; 118(4):505-17. Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E. PMID: 19360426; PMCID: PMC2737113.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    105. Alzheimer's disease in Down syndrome: neurobiology and risk. Ment Retard Dev Disabil Res Rev. 2007; 13(3):237-46. Zigman WB, Lott IT. PMID: 17910085.
      View in: PubMed   Mentions: 121     Fields:    Translation:Humans
    106. Toward a research agenda for Down syndrome. Ment Retard Dev Disabil Res Rev. 2007; 13(3):288-9. Lott IT, Patterson D, Seltzer MM. PMID: 17910088.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    107. Beta-amyloid, oxidative stress and down syndrome. Curr Alzheimer Res. 2006 Dec; 3(5):521-8. Lott IT, Head E, Doran E, Busciglio J. PMID: 17168651.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    108. Telemedicine, dementia and Down syndrome: implications for Alzheimer disease. Alzheimers Dement. 2006 Jul; 2(3):179-84. Lott IT, Doran E, Walsh DM, Hill MA. PMID: 19595881.
      View in: PubMed   Mentions: 8     Fields:    
    109. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol Aging. 2005 Mar; 26(3):383-9. Lott IT, Head E. PMID: 15639317.
      View in: PubMed   Mentions: 76     Fields:    Translation:Humans
    110. Learning and memory as a function of age in Down syndrome: a study using animal-based tasks. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):443-53. Nelson L, Johnson JK, Freedman M, Lott I, Groot J, Chang M, Milgram NW, Head E. PMID: 15795053.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    111. Longitudinal prescribing patterns for psychoactive medications in community-based individuals with developmental disabilities: utilization of pharmacy records. J Intellect Disabil Res. 2004 Sep; 48(Pt 6):563-71. Lott IT, McGregor M, Engelman L, Touchette P, Tournay A, Sandman C, Fernandez G, Plon L, Walsh D. PMID: 15312057.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    112. Down syndrome and beta-amyloid deposition. Curr Opin Neurol. 2004 Apr; 17(2):95-100. Head E, Lott IT. PMID: 15021233.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    113. Down syndrome and Alzheimer disease: response to donepezil. Arch Neurol. 2002 Jul; 59(7):1133-6. Lott IT, Osann K, Doran E, Nelson L. PMID: 12117361.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    114. Down syndrome and Alzheimer's disease: a link between development and aging. Ment Retard Dev Disabil Res Rev. 2001; 7(3):172-8. Lott IT, Head E. PMID: 11553933.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
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