Karina S. Cramer

Title(s)Professor and Associate Dean for Academic Affairs, Neurobiology & Behavior
SchoolSchool of Biological Sciences
Address2215 McGaugh Hall
Zot 4550
Irvine CA 92697
Phone(949) 824-4211
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    Collapse Research 
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    Glial Influences on Auditory Brainstem Development
    NIH R01DC010796Jan 1, 2011 - May 31, 2021
    Role: Principal Investigator
    Eph Signaling Auditory Brainstem Development
    NIH R01DC005771Jul 1, 2003 - Jun 30, 2010
    Role: Principal Investigator
    VISUAL ACTIVITY AND VISUAL SYSTEM DEVELOPMENT
    NIH F32EY006423Jan 2, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Loss of C1q alters the auditory brainstem response. Front Cell Neurosci. 2024; 18:1464670. Chokr SM, Bui-Tran A, Cramer KS. PMID: 39416682; PMCID: PMC11480778.
      View in: PubMed   Mentions:
    2. Deep Conservation and Unexpected Evolutionary History of Neighboring lncRNAs MALAT1 and NEAT1. J Mol Evol. 2024 Feb; 92(1):30-41. Weghorst F, Torres Marcén M, Faridi G, Lee YCG, Cramer KS. PMID: 38189925; PMCID: PMC10869381.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Long-term microglia depletion impairs synapse elimination and auditory brainstem function. Sci Rep. 2022 11 02; 12(1):18521. Chokr SM, Milinkeviciute G, Jimenez GA, Abubakr H, Cramer KS. PMID: 36323869; PMCID: PMC9630367.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. Non-Apoptotic Caspase Activity Preferentially Targets a Novel Consensus Sequence Associated With Cytoskeletal Proteins in the Developing Auditory Brainstem. Front Cell Dev Biol. 2022; 10:844844. Weghorst F, Mirzakhanyan Y, Hernandez KL, Gershon PD, Cramer KS. PMID: 35330912; PMCID: PMC8940215.
      View in: PubMed   Mentions: 3  
    5. Synapse Maturation and Developmental Impairment in the Medial Nucleus of the Trapezoid Body. Front Integr Neurosci. 2022; 16:804221. Chokr SM, Milinkeviciute G, Cramer KS. PMID: 35221938; PMCID: PMC8863736.
      View in: PubMed   Mentions:
    6. Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity. EMBO Mol Med. 2021 08 09; 13(8):e13086. Jayashankar V, Selwan E, Hancock SE, Verlande A, Goodson MO, Eckenstein KH, Milinkeviciute G, Hoover BM, Chen B, Fleischman AG, Cramer KS, Hanessian S, Masri S, Turner N, Edinger AL. PMID: 34231322; PMCID: PMC8350895.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    7. CX3CR1 mutation alters synaptic and astrocytic protein expression, topographic gradients, and response latencies in the auditory brainstem. J Comp Neurol. 2021 08 01; 529(11):3076-3097. Milinkeviciute G, Chokr SM, Castro EM, Cramer KS. PMID: 33797066; PMCID: PMC8174095.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    8. Auditory Brainstem Deficits from Early Treatment with a CSF1R Inhibitor Largely Recover with Microglial Repopulation. eNeuro. 2021 Mar-Apr; 8(2). Milinkeviciute G, Chokr SM, Cramer KS. PMID: 33558268; PMCID: PMC8009669.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. Caspase-3 Cleaves Extracellular Vesicle Proteins During Auditory Brainstem Development. Front Cell Neurosci. 2020; 14:573345. Weghorst F, Mirzakhanyan Y, Samimi K, Dhillon M, Barzik M, Cunningham LL, Gershon PD, Cramer KS. PMID: 33281555; PMCID: PMC7689216.
      View in: PubMed   Mentions: 10  
    10. Mechanisms underlying auditory processing deficits in Fragile X syndrome. FASEB J. 2020 03; 34(3):3501-3518. McCullagh EA, Rotschafer SE, Auerbach BD, Klug A, Kaczmarek LK, Cramer KS, Kulesza RJ, Razak KA, Lovelace JW, Lu Y, Koch U, Wang Y. PMID: 32039504; PMCID: PMC7347277.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    11. Microglia Regulate Pruning of Specialized Synapses in the Auditory Brainstem. Front Neural Circuits. 2019; 13:55. Milinkeviciute G, Henningfield CM, Muniak MA, Chokr SM, Green KN, Cramer KS. PMID: 31555101; PMCID: PMC6722190.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    12. The evolution of hearing and balance. Elife. 2019 02 08; 8. Weghorst FP, Cramer KS. PMID: 30735124; PMCID: PMC6368400.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    13. Developmental Emergence of Phenotypes in the Auditory Brainstem Nuclei of Fmr1 Knockout Mice. eNeuro. 2017 Nov-Dec; 4(6). Rotschafer SE, Cramer KS. PMID: 29291238; PMCID: PMC5744645.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    14. Axonal Cleaved Caspase-3 Regulates Axon Targeting and Morphogenesis in the Developing Auditory Brainstem. Front Neural Circuits. 2016; 10:84. Rotschafer SE, Allen-Sharpley MR, Cramer KS. PMID: 27822180; PMCID: PMC5075536.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. Glial Cell Contributions to Auditory Brainstem Development. Front Neural Circuits. 2016; 10:83. Cramer KS, Rubel EW. PMID: 27818624; PMCID: PMC5073128.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Eph-ephrin signaling in nervous system development. F1000Res. 2016; 5. Cramer KS, Miko IJ. PMID: 27092247; PMCID: PMC4821289.
      View in: PubMed   Mentions: 35     Fields:    
    17. Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons. Neural Dev. 2015 Dec 15; 10:27. Abdul-Latif ML, Salazar JA, Marshak S, Dinh ML, Cramer KS. PMID: 26666565; PMCID: PMC4678660.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    18. Deletion of Fmr1 alters function and synaptic inputs in the auditory brainstem. PLoS One. 2015; 10(2):e0117266. Rotschafer SE, Marshak S, Cramer KS. PMID: 25679778; PMCID: PMC4332492.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    19. Axon guidance in the auditory system: multiple functions of Eph receptors. Neuroscience. 2014 Sep 26; 277:152-62. Cramer KS, Gabriele ML. PMID: 25010398; PMCID: PMC4164577.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    20. Differential roles for EphA and EphB signaling in segregation and patterning of central vestibulocochlear nerve projections. PLoS One. 2013; 8(10):e78658. Allen-Sharpley MR, Tjia M, Cramer KS. PMID: 24130906; PMCID: PMC3795076.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. Selective tracing of auditory fibers in the avian embryonic vestibulocochlear nerve. J Vis Exp. 2013 Mar 18; (73):e50305. Allen-Sharpley MR, Tjia M, Cramer KS. PMID: 23542875; PMCID: PMC3639547.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. EphB2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem. Neural Dev. 2013 Feb 05; 8:2. Nakamura PA, Cramer KS. PMID: 23379484; PMCID: PMC3575227.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. Coordinated Eph-ephrin signaling guides migration and axon targeting in the avian auditory system. Neural Dev. 2012 Aug 21; 7:29. Allen-Sharpley MR, Cramer KS. PMID: 22908944; PMCID: PMC3515360.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    24. EphB signaling regulates target innervation in the developing and deafferented auditory brainstem. Dev Neurobiol. 2012 Sep; 72(9):1243-55. Nakamura PA, Hsieh CY, Cramer KS. PMID: 22021100; PMCID: PMC3418463.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. Astrocyte-secreted factors modulate the developmental distribution of inhibitory synapses in nucleus laminaris of the avian auditory brainstem. J Comp Neurol. 2012 Apr 15; 520(6):1262-77. Korn MJ, Koppel SJ, Li LH, Mehta D, Mehta SB, Seidl AH, Cramer KS. PMID: 22020566; PMCID: PMC3926803.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    26. Astrocyte-secreted factors modulate a gradient of primary dendritic arbors in nucleus laminaris of the avian auditory brainstem. PLoS One. 2011; 6(11):e27383. Korn MJ, Koppel SJ, Cramer KS. PMID: 22087304; PMCID: PMC3210166.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex. PLoS One. 2011; 6(10):e26192. Intskirveli I, Metherate R, Cramer KS. PMID: 22022561; PMCID: PMC3192161.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    28. Formation and maturation of the calyx of Held. Hear Res. 2011 Jun; 276(1-2):70-8. Nakamura PA, Cramer KS. PMID: 21093567; PMCID: PMC3109188.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    29. Ephrin-B reverse signaling is required for formation of strictly contralateral auditory brainstem pathways. J Neurosci. 2010 Jul 21; 30(29):9840-9. Hsieh CY, Nakamura PA, Luk SO, Miko IJ, Henkemeyer M, Cramer KS. PMID: 20660266; PMCID: PMC2921927.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    30. Distribution of glial-associated proteins in the developing chick auditory brainstem. Dev Neurobiol. 2008 Jul; 68(8):1093-106. Korn MJ, Cramer KS. PMID: 18498086.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. Auditory brainstem neural activation patterns are altered in EphA4- and ephrin-B2-deficient mice. J Comp Neurol. 2007 Dec 20; 505(6):669-81. Miko IJ, Nakamura PA, Henkemeyer M, Cramer KS. PMID: 17948875.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    32. Deletion of EphA4 enhances deafferentation-induced ipsilateral sprouting in auditory brainstem projections. J Comp Neurol. 2007 Oct 10; 504(5):508-18. Hsieh CY, Hong CT, Cramer KS. PMID: 17702003.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    33. EphA4 misexpression alters tonotopic projections in the auditory brainstem. Dev Neurobiol. 2007 Oct; 67(12):1655-68. Huffman KJ, Cramer KS. PMID: 17577206.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    34. Windowing chicken eggs for developmental studies. J Vis Exp. 2007; (8):306. Korn MJ, Cramer KS. PMID: 18989413; PMCID: PMC2562489.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    35. Placing growth factor-coated beads on early stage chicken embryos. J Vis Exp. 2007; (8):307. Korn MJ, Cramer KS. PMID: 18989414; PMCID: PMC2562490.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    36. Auditory brainstem responses are impaired in EphA4 and ephrin-B2 deficient mice. Hear Res. 2008 Jan; 235(1-2):39-46. Miko IJ, Henkemeyer M, Cramer KS. PMID: 17967521; PMCID: PMC3250224.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    37. Deafferentation induces novel axonal projections in the auditory brainstem after hearing onset. J Comp Neurol. 2006 Aug 01; 497(4):589-99. Hsieh CY, Cramer KS. PMID: 16739167.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    38. EphB2 regulates axonal growth at the midline in the developing auditory brainstem. Dev Biol. 2006 Jul 01; 295(1):76-89. Cramer KS, Cerretti DP, Siddiqui SA. PMID: 16626680.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    39. Eph proteins and the assembly of auditory circuits. Hear Res. 2005 Aug; 206(1-2):42-51. Cramer KS. PMID: 16080997.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    40. Differential expression of Eph receptors and ephrins in the cochlear ganglion and eighth cranial nerve of the chick embryo. J Comp Neurol. 2005 Feb 21; 482(4):309-19. Siddiqui SA, Cramer KS. PMID: 15669077.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    41. Avian superior olivary nucleus provides divergent inhibitory input to parallel auditory pathways. J Comp Neurol. 2005 Jan 03; 481(1):6-18. Burger RM, Cramer KS, Pfeiffer JD, Rubel EW. PMID: 15558730.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    42. Tonotopic gradients of Eph family proteins in the chick nucleus laminaris during synaptogenesis. J Neurobiol. 2004 Jul; 60(1):28-39. Person AL, Cerretti DP, Pasquale EB, Rubel EW, Cramer KS. PMID: 15188270.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    43. EphA4 signaling promotes axon segregation in the developing auditory system. Dev Biol. 2004 May 01; 269(1):26-35. Cramer KS, Bermingham-McDonogh O, Krull CE, Rubel EW. PMID: 15081355.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    44. Ephrin-A5 exerts positive or inhibitory effects on distinct subsets of EphA4-positive motor neurons. J Neurosci. 2004 Feb 04; 24(5):1070-8. Eberhart J, Barr J, O'Connell S, Flagg A, Swartz ME, Cramer KS, Tosney KW, Pasquale EB, Krull CE. PMID: 14762125; PMCID: PMC6793576.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    45. Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem. J Comp Neurol. 2002 Oct 07; 452(1):51-64. Cramer KS, Karam SD, Bothwell M, Cerretti DP, Pasquale EB, Rubel EW. PMID: 12205709.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    46. Choosing axonal real estate: location, location, location. J Comp Neurol. 2002 Jun 17; 448(1):1-5. Rubel EW, Cramer KS. PMID: 12012372.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
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