Chan, Jefferson

Title(s)Professor, Pathology
Phone(949) 824-9605
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    Collapse Research 
    Collapse Research Activities and Funding
    Nrf1-dependent regulation of cellular stress response
    NIH/NIEHS R56ES027891Feb 1, 2018 - Jan 31, 2019
    Role: Principal Investigator
    Regulation of Stress Response in Neurons
    NIH/NINDS R01NS065223Sep 30, 2009 - Nov 30, 2014
    Role: Principal Investigator
    Molecular and metabolic pathology of CNC-bZIP knockouts
    NIH/NCI R56CA091907Jul 1, 2008 - Jun 30, 2009
    Role: Principal Investigator
    Nrf1 function by conditional knockout
    NIH/NIDDK R03DK063757Jun 15, 2002 - Dec 31, 2003
    Role: Principal Investigator
    Molecular and metabolic pathology of CNC-bZIP knockouts
    NIH/NCI R01CA091907Jul 1, 2001 - Apr 30, 2016
    Role: Principal Investigator
    NIH/NIDDK K08DK002603Mar 15, 1999 - Dec 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Han JW, Valdez JL, Ho DV, Lee CS, Kim HM, Wang X, Huang L, Chan JY. Nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) is regulated by O-GlcNAc transferase. Free Radic Biol Med. 2017 09; 110:196-205. PMID: 28625484.
      View in: PubMed
    2. Kim HM, Han JW, Chan JY. Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation. Gene. 2016 Jun 10; 584(1):17-25. PMID: 26947393.
      View in: PubMed
    3. Lim J, Ortiz L, Nakamura BN, Hoang YD, Banuelos J, Flores VN, Chan JY, Luderer U. Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice. Reprod Toxicol. 2015 Dec; 58:24-32. PMID: 26247513; PMCID: PMC4690751 [Available on 12/01/16].
    4. Ho DV, Chan JY. Induction of Herpud1 expression by ER stress is regulated by Nrf1. FEBS Lett. 2015 Feb 27; 589(5):615-20. PMID: 25637874.
      View in: PubMed
    5. Li S, Vaziri ND, Masuda Y, Hajighasemi-Ossareh M, Robles L, Le A, Vo K, Chan JY, Foster CE, Stamos MJ, Ichii H. Pharmacological activation of Nrf2 pathway improves pancreatic islet isolation and transplantation. Cell Transplant. 2015; 24(11):2273-83. PMID: 25581574.
      View in: PubMed
    6. Lau WL, Liu SM, Pahlevan S, Yuan J, Khazaeli M, Ni Z, Chan JY, Vaziri ND. Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption. Dig Dis Sci. 2015 May; 60(5):1215-22. PMID: 25399330.
      View in: PubMed
    7. Polishchuk EV, Concilli M, Iacobacci S, Chesi G, Pastore N, Piccolo P, Paladino S, Baldantoni D, van IJzendoorn SC, Chan J, Chang CJ, Amoresano A, Pane F, Pucci P, Tarallo A, Parenti G, Brunetti-Pierri N, Settembre C, Ballabio A, Polishchuk RS. Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis. Dev Cell. 2014 Jun 23; 29(6):686-700. PMID: 24909901; PMCID: PMC4070386.
    8. Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GT, Fukada Y, Meng QJ. The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes Dev. 2014 Mar 15; 28(6):548-60. PMID: 24637114; PMCID: PMC3967045.
    9. Lee CS, Ho DV, Chan JY. Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice. FEBS J. 2013 Aug; 280(15):3609-20. PMID: 23702335; PMCID: PMC3835180.
    10. Biswas M, Kwong EK, Park E, Nagra P, Chan JY. Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1. Exp Cell Res. 2013 Aug 01; 319(13):1922-31. PMID: 23623971; PMCID: PMC4186750.
    11. Schneider KS, Chan JY. Emerging role of Nrf2 in adipocytes and adipose biology. Adv Nutr. 2013 Jan 01; 4(1):62-6. PMID: 23319124; PMCID: PMC3648740.
    12. Kwong EK, Kim KM, Penalosa PJ, Chan JY. Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes. PLoS One. 2012; 7(10):e48404. PMID: 23144760; PMCID: PMC3483171.
    13. Oh DH, Rigas D, Cho A, Chan JY. Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability. FEBS J. 2012 Nov; 279(22):4121-30. PMID: 22971132; PMCID: PMC3835192.
    14. Cheung KL, Lee JH, Khor TO, Wu TY, Li GX, Chan J, Yang CS, Kong AN. Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation. Mol Carcinog. 2014 Jan; 53(1):77-84. PMID: 22911891.
      View in: PubMed
    15. Biswas M, Phan D, Watanabe M, Chan JY. The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis. J Biol Chem. 2011 Nov 11; 286(45):39282-9. PMID: 21953459; PMCID: PMC3234752.
    16. Lee CS, Lee C, Hu T, Nguyen JM, Zhang J, Martin MV, Vawter MP, Huang EJ, Chan JY. Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8408-13. PMID: 21536885; PMCID: PMC3100960.
    17. Nakamura BN, Lawson G, Chan JY, Banuelos J, Cort├ęs MM, Hoang YD, Ortiz L, Rau BA, Luderer U. Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner. Free Radic Biol Med. 2010 Nov 15; 49(9):1368-79. PMID: 20692336; PMCID: PMC2948056.
    18. Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M, Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL, Freeman ML, Blackwell TS. NADPH oxidase limits innate immune responses in the lungs in mice. PLoS One. 2010 Mar 16; 5(3):e9631. PMID: 20300512; PMCID: PMC2838778.
    19. Pi J, Leung L, Xue P, Wang W, Hou Y, Liu D, Yehuda-Shnaidman E, Lee C, Lau J, Kurtz TW, Chan JY. Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J Biol Chem. 2010 Mar 19; 285(12):9292-300. PMID: 20089859; PMCID: PMC2838347.
    20. Biswas M, Chan JY. Role of Nrf1 in antioxidant response element-mediated gene expression and beyond. Toxicol Appl Pharmacol. 2010 Apr 01; 244(1):16-20. PMID: 19665035; PMCID: PMC2837788.
    21. Wang W, Kwok AM, Chan JY. The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription. J Biol Chem. 2007 Aug 24; 282(34):24670-8. PMID: 17609210.
      View in: PubMed
    22. Wang W, Chan JY. Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. J Biol Chem. 2006 Jul 14; 281(28):19676-87. PMID: 16687406.
      View in: PubMed
    23. Xu Z, Chen L, Leung L, Yen TS, Lee C, Chan JY. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci U S A. 2005 Mar 15; 102(11):4120-5. PMID: 15738389; PMCID: PMC554825.
    24. Leung L, Kwong M, Hou S, Lee C, Chan JY. Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J Biol Chem. 2003 Nov 28; 278(48):48021-9. PMID: 12968018.
      View in: PubMed