Jefferson Chan

Title(s)Professor, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-9605
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    Nrf1-dependent regulation of cellular stress response your title
    NIH R01ES029481Aug 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Nrf1-dependent regulation of cellular stress response
    NIH R56ES027891Feb 1, 2018 - Jan 31, 2020
    Role: Principal Investigator
    Regulation of Stress Response in Neurons
    NIH R01NS065223Sep 30, 2009 - Nov 30, 2015
    Role: Principal Investigator
    Molecular and metabolic pathology of CNC-bZIP knockouts
    NIH R56CA091907Jul 1, 2008 - Jun 30, 2009
    Role: Principal Investigator
    Nrf1 function by conditional knockout
    NIH R03DK063757Jun 15, 2002 - Dec 31, 2003
    Role: Principal Investigator
    Molecular and metabolic pathology of CNC-bZIP knockouts
    NIH R01CA091907Jul 1, 2001 - Apr 30, 2016
    Role: Principal Investigator
    NRF1 IN OXIDATIVE STRESS
    NIH K08DK002603Mar 15, 1999 - Dec 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Characterization of NFE2L1-616, an isoform of nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes. Sci Rep. 2023 11 14; 13(1):19900. Ho DV, Suryajaya KG, Manh K, Duong AN, Chan JY. PMID: 37963997; PMCID: PMC10646089.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. The Nrf1 transcription factor is induced by patulin and protects against patulin cytotoxicity. Toxicology. 2022 Apr 15; 471:153173. Han JJW, Nguyen CD, Thrasher JP, DeGuzman A, Chan JY. PMID: 35367319; PMCID: PMC9522914.
      View in: PubMed   Mentions:    Fields:    
    3. A novel nonsense variant in the NFE2L1 transcription factor in a patient with developmental delay, hypotonia, genital anomalies, and failure to thrive. Hum Mutat. 2022 04; 43(4):471-476. Wang JM, Ho DV, Kritzer A, Chan JY. PMID: 35112409; PMCID: PMC8960367.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. The deubiquitinating enzyme USP7 regulates the transcription factor Nrf1 by modulating its stability in response to toxic metal exposure. J Biol Chem. 2021 Jan-Jun; 296:100732. Han JJW, Ho DV, Kim HM, Lee JY, Jeon YS, Chan JY. PMID: 33933455; PMCID: PMC8163974.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. Nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) is regulated by O-GlcNAc transferase. Free Radic Biol Med. 2017 09; 110:196-205. Han JW, Valdez JL, Ho DV, Lee CS, Kim HM, Wang X, Huang L, Chan JY. PMID: 28625484.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    6. Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation. Gene. 2016 Jun 10; 584(1):17-25. Kim HM, Han JW, Chan JY. PMID: 26947393; PMCID: PMC6636332.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    7. Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice. Reprod Toxicol. 2015 Dec; 58:24-32. Lim J, Ortiz L, Nakamura BN, Hoang YD, Banuelos J, Flores VN, Chan JY, Luderer U. PMID: 26247513; PMCID: PMC4690751.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    8. Induction of Herpud1 expression by ER stress is regulated by Nrf1. FEBS Lett. 2015 Feb 27; 589(5):615-20. Ho DV, Chan JY. PMID: 25637874; PMCID: PMC10084809.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    9. Pharmacological activation of Nrf2 pathway improves pancreatic islet isolation and transplantation. Cell Transplant. 2015; 24(11):2273-83. Li S, Vaziri ND, Masuda Y, Hajighasemi-Ossareh M, Robles L, Le A, Vo K, Chan JY, Foster CE, Stamos MJ, Ichii H. PMID: 25581574.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    10. Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption. Dig Dis Sci. 2015 May; 60(5):1215-22. Lau WL, Liu SM, Pahlevan S, Yuan J, Khazaeli M, Ni Z, Chan JY, Vaziri ND. PMID: 25399330.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    11. Copper is an endogenous modulator of neural circuit spontaneous activity. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16280-5. Dodani SC, Firl A, Chan J, Nam CI, Aron AT, Onak CS, Ramos-Torres KM, Paek J, Webster CM, Feller MB, Chang CJ. PMID: 25378701; PMCID: PMC4246333.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    12. Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis. Dev Cell. 2014 Jun 23; 29(6):686-700. Polishchuk EV, Concilli M, Iacobacci S, Chesi G, Pastore N, Piccolo P, Paladino S, Baldantoni D, van IJzendoorn SC, Chan J, Chang CJ, Amoresano A, Pane F, Pucci P, Tarallo A, Parenti G, Brunetti-Pierri N, Settembre C, Ballabio A, Polishchuk RS. PMID: 24909901; PMCID: PMC4070386.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    13. The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes Dev. 2014 Mar 15; 28(6):548-60. Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GT, Fukada Y, Meng QJ. PMID: 24637114; PMCID: PMC3967045.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    14. Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice. FEBS J. 2013 Aug; 280(15):3609-20. Lee CS, Ho DV, Chan JY. PMID: 23702335; PMCID: PMC3835180.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    15. Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1. Exp Cell Res. 2013 Aug 01; 319(13):1922-1931. Biswas M, Kwong EK, Park E, Nagra P, Chan JY. PMID: 23623971; PMCID: PMC4186750.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    16. Emerging role of Nrf2 in adipocytes and adipose biology. Adv Nutr. 2013 Jan 01; 4(1):62-6. Schneider KS, Chan JY. PMID: 23319124; PMCID: PMC3648740.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    17. Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes. PLoS One. 2012; 7(10):e48404. Kwong EK, Kim KM, Penalosa PJ, Chan JY. PMID: 23144760; PMCID: PMC3483171.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability. FEBS J. 2012 Nov; 279(22):4121-30. Oh DH, Rigas D, Cho A, Chan JY. PMID: 22971132; PMCID: PMC3835192.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    19. Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation. Mol Carcinog. 2014 Jan; 53(1):77-84. Cheung KL, Lee JH, Khor TO, Wu TY, Li GX, Chan J, Yang CS, Kong AN. PMID: 22911891.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    20. The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis. J Biol Chem. 2011 Nov 11; 286(45):39282-9. Biswas M, Phan D, Watanabe M, Chan JY. PMID: 21953459; PMCID: PMC3234752.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    21. Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8408-13. Lee CS, Lee C, Hu T, Nguyen JM, Zhang J, Martin MV, Vawter MP, Huang EJ, Chan JY. PMID: 21536885; PMCID: PMC3100960.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    22. Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner. Free Radic Biol Med. 2010 Nov 15; 49(9):1368-79. Nakamura BN, Lawson G, Chan JY, Banuelos J, Cortés MM, Hoang YD, Ortiz L, Rau BA, Luderer U. PMID: 20692336; PMCID: PMC2948056.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    23. NADPH oxidase limits innate immune responses in the lungs in mice. PLoS One. 2010 Mar 16; 5(3):e9631. Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M, Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL, Freeman ML, Blackwell TS. PMID: 20300512; PMCID: PMC2838778.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    24. Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J Biol Chem. 2010 Mar 19; 285(12):9292-300. Pi J, Leung L, Xue P, Wang W, Hou Y, Liu D, Yehuda-Shnaidman E, Lee C, Lau J, Kurtz TW, Chan JY. PMID: 20089859; PMCID: PMC2838347.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    25. Role of Nrf1 in antioxidant response element-mediated gene expression and beyond. Toxicol Appl Pharmacol. 2010 Apr 01; 244(1):16-20. Biswas M, Chan JY. PMID: 19665035; PMCID: PMC2837788.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    26. The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription. J Biol Chem. 2007 Aug 24; 282(34):24670-8. Wang W, Kwok AM, Chan JY. PMID: 17609210.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    27. Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. J Biol Chem. 2006 Jul 14; 281(28):19676-87. Wang W, Chan JY. PMID: 16687406.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    28. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci U S A. 2005 Mar 15; 102(11):4120-5. Xu Z, Chen L, Leung L, Yen TS, Lee C, Chan JY. PMID: 15738389; PMCID: PMC554825.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    29. Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J Biol Chem. 2003 Nov 28; 278(48):48021-9. Leung L, Kwong M, Hou S, Lee C, Chan JY. PMID: 12968018.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
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