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Magdalene J Seiler

Title(s)Associate Professor In Residence, Physical Medicine and Rehabilitation
Phone(949) 824-2037
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    Collapse Biography 
    Collapse Education and Training
    Ludwig-Maximilians-University, Munich, GermanyDiploma06/1982Zoology
    Max-Planck-Institute for Neurochemistry, Ludwig-Maximilians-University , Martinsried & Munich, GermanyPh.D.12/1985Neurochemistry

    Collapse Overview 
    Collapse Overview
    Research Focus: Retinal sheet transplantation and demonstration of vision restoration in rat models of retinal degeneration and ultimately in retinal degeneration patients. See also lab website at http://sites.uci.edu/seilerlab/magdalenejseiler
    Detail on Research
    My primary scientific interests are in retinal transplantation, retinal degeneration models, retinal development, stem cells and neurotrophic factors. Along with my colleague, Dr. Robert Aramant, I have developed and refined a unique procedure of retinal sheet transplantation which has demonstrated improvement of visual responses in four different retinal degeneration models (RCS rats, rd mice, rhodopsin S334ter-3 and -5 rat models of fast and slow retinal degeneration). This lead to Phase I and II clinical trials that showed visual improvement in RP and AMD patients.
    In 2014, I received a 3-year Early Translational grant from CIRM with the goal of developing human embryonic stem cells to transplantable 3-D sheets of retinal progenitor cells for vision restoration. We have now demonstrated that stem-cell derived retina can improve visual responses in 2 different immunodeficient rat models with retinal degeneration that do not reject human cells. This research was done in collaboration with Dr. Hans Keirstead (at UC Irvine until 2014; now CEO of AIVITA Biomedical, Irvine). In 2018, I received a 4.7 million TRAN1 grant (2.5 years) entitled “Morphological and functional integration of stem cell derived retina organoid sheets into degenerating retina models.” that will develop this application towards a treatment for Retinitis Pigmentosa (see press release June 2018)

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Singh RK, Winkler P, Binette F, Glickman RD, Seiler M, Petersen-Jones SM, Nasonkin IO. Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue. J Tissue Eng Regen Med. 2020 Jan 06. PMID: 31908157.
      View in: PubMed
    2. Foik AT, Lean GA, Scholl LR, McLelland BT, Mathur A, Aramant RB, Seiler MJ, Lyon DC. Detailed Visual Cortical Responses Generated by Retinal Sheet Transplants in Rats with Severe Retinal Degeneration. J Neurosci. 2018 12 12; 38(50):10709-10724. PMID: 30396913.
      View in: PubMed
    3. Thomas BB, Zhu D, Lin TC, Kim YC, Seiler MJ, Martinez-Camarillo JC, Lin B, Shad Y, Hinton DR, Humayun MS. A new immunodeficient retinal dystrophic rat model for transplantation studies using human-derived cells. Graefes Arch Clin Exp Ophthalmol. 2018 Nov; 256(11):2113-2125. PMID: 30215097.
      View in: PubMed
    4. Lin B, McLelland BT, Mathur A, Aramant RB, Seiler MJ. Sheets of human retinal progenitor transplants improve vision in rats with severe retinal degeneration. Exp Eye Res. 2018 09; 174:13-28. PMID: 29782826.
      View in: PubMed
    5. McLelland BT, Lin B, Mathur A, Aramant RB, Thomas BB, Nistor G, Keirstead HS, Seiler MJ. Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats. Invest Ophthalmol Vis Sci. 2018 05 01; 59(6):2586-2603. PMID: 29847666.
      View in: PubMed
    6. Lin TC, Seiler MJ, Zhu D, Falabella P, Hinton DR, Clegg DO, Humayun MS, Thomas BB. Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models. Stem Cells Int. 2017; 2017:9428176. PMID: 28928775.
      View in: PubMed
    7. Seiler MJ. hESC-derived photoreceptors survive and integrate better in immunodeficient retina. Stem Cell Investig. 2017; 4:70. PMID: 28920063.
      View in: PubMed
    8. Seiler MJ, Lin RE, McLelland BT, Mathur A, Lin B, Sigman J, De Guzman AT, Kitzes LM, Aramant RB, Thomas BB. Vision Recovery and Connectivity by Fetal Retinal Sheet Transplantation in an Immunodeficient Retinal Degenerate Rat Model. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):614-630. PMID: 28129425.
      View in: PubMed
    9. Seiler MJ, Aramant RB, Jones MK, Ferguson DL, Bryda EC, Keirstead HS. A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression. Graefes Arch Clin Exp Ophthalmol. 2014 Jul; 252(7):1079-92. PMID: 24817311.
      View in: PubMed
    10. Seiler MJ, Aramant RB. Cell replacement and visual restoration by retinal sheet transplants. Prog Retin Eye Res. 2012 Nov; 31(6):661-87. PMID: 22771454.
      View in: PubMed
    11. Seiler MJ, Jones BW, Aramant RB, Yang PB, Keirstead HS, Marc RE. Computational molecular phenotyping of retinal sheet transplants to rats with retinal degeneration. Eur J Neurosci. 2012 Jun; 35(11):1692-704. PMID: 22594836.
      View in: PubMed
    12. Harness JV, Turovets NA, Seiler MJ, Nistor G, Altun G, Agapova LS, Ferguson D, Laurent LC, Loring JF, Keirstead HS. Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells. PLoS One. 2011 Jan 07; 6(1):e14499. PMID: 21249129.
      View in: PubMed
    13. Martinez-Navarrete G, Seiler MJ, Aramant RB, Fernandez-Sanchez L, Pinilla I, Cuenca N. Retinal degeneration in two lines of transgenic S334ter rats. Exp Eye Res. 2011 Mar; 92(3):227-37. PMID: 21147100.
      View in: PubMed
    14. Yang PB, Seiler MJ, Aramant RB, Yan F, Mahoney MJ, Kitzes LM, Keirstead HS. Trophic factors GDNF and BDNF improve function of retinal sheet transplants. Exp Eye Res. 2010 Nov; 91(5):727-38. PMID: 20804751.
      View in: PubMed
    15. Nistor G, Seiler MJ, Yan F, Ferguson D, Keirstead HS. Three-dimensional early retinal progenitor 3D tissue constructs derived from human embryonic stem cells. J Neurosci Methods. 2010 Jun 30; 190(1):63-70. PMID: 20447416.
      View in: PubMed
    16. Seiler MJ, Rao B, Aramant RB, Yu L, Wang Q, Kitayama E, Pham S, Yan F, Chen Z, Keirstead HS. Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats. J Neurosci Methods. 2010 May 15; 188(2):250-7. PMID: 20219535.
      View in: PubMed
    17. Seiler MJ, Aramant RB, Thomas BB, Peng Q, Sadda SR, Keirstead HS. Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets. Eur J Neurosci. 2010 Feb; 31(3):508-20. PMID: 20105230.
      View in: PubMed
    18. Seiler MJ, Aramant RB, Seeliger MW, Bragadottir R, Mahoney M, Narfstrom K. Functional and structural assessment of retinal sheet allograft transplantation in feline hereditary retinal degeneration. Vet Ophthalmol. 2009 May-Jun; 12(3):158-69. PMID: 19392875.
      View in: PubMed
    19. Seiler MJ, Thomas BB, Chen Z, Wu R, Sadda SR, Aramant RB. Retinal transplants restore visual responses: trans-synaptic tracing from visually responsive sites labels transplant neurons. Eur J Neurosci. 2008 Jul; 28(1):208-20. PMID: 18662343.
      View in: PubMed
    20. Radtke ND, Aramant RB, Petry HM, Green PT, Pidwell DJ, Seiler MJ. Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium. Am J Ophthalmol. 2008 Aug; 146(2):172-182. PMID: 18547537.
      View in: PubMed
    21. Leung KW, Liu M, Xu X, Seiler MJ, Barnstable CJ, Tombran-Tink J. Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1221-31. PMID: 18326752.
      View in: PubMed
    22. Seiler MJ, Thomas BB, Chen Z, Arai S, Chadalavada S, Mahoney MJ, Sadda SR, Aramant RB. BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function. Exp Eye Res. 2008 Jan; 86(1):92-104. PMID: 17983616.
      View in: PubMed
    23. Peng Q, Thomas BB, Aramant RB, Chen Z, Sadda SR, Seiler MJ. Structure and function of embryonic rat retinal sheet transplants. Curr Eye Res. 2007 Sep; 32(9):781-9. PMID: 17882711.
      View in: PubMed
    24. Thomas BB, Seiler MJ, Aramant RB, Samant D, Qiu G, Vyas N, Arai S, Chen Z, Sadda SR. Visual functional effects of constant blue light in a retinal degenerate rat model. Photochem Photobiol. 2007 May-Jun; 83(3):759-65. PMID: 17115798.
      View in: PubMed
    25. Colodetti L, Weiland JD, Colodetti S, Ray A, Seiler MJ, Hinton DR, Humayun MS. Pathology of damaging electrical stimulation in the retina. Exp Eye Res. 2007 Jul; 85(1):23-33. PMID: 17531974.
      View in: PubMed
    26. Qiu G, Seiler MJ, Thomas BB, Wu K, Radosevich M, Sadda SR. Revisiting nestin expression in retinal progenitor cells in vitro and after transplantation in vivo. Exp Eye Res. 2007 Jun; 84(6):1047-59. PMID: 17451684.
      View in: PubMed
    27. Thomas BB, Samant DM, Seiler MJ, Aramant RB, Sheikholeslami S, Zhang K, Chen Z, Sadda SR. Behavioral evaluation of visual function of rats using a visual discrimination apparatus. J Neurosci Methods. 2007 May 15; 162(1-2):84-90. PMID: 17289151.
      View in: PubMed
    28. Thomas BB, Aramant RB, Sadda SR, Seiler MJ. Retinal transplantation. A treatment strategy for retinal degenerative diseases. Adv Exp Med Biol. 2006; 572:367-76. PMID: 17249598.
      View in: PubMed
    29. Thomas BB, Aramant RB, Sadda SR, Seiler MJ. Light response differences in the superior colliculus of albino and pigmented rats. Neurosci Lett. 2005 Sep 09; 385(2):143-7. PMID: 15950381.
      View in: PubMed
    30. Thomas BB, Arai S, Ikai Y, Qiu G, Chen Z, Aramant RB, Sadda SR, Seiler MJ. Retinal transplants evaluated by optical coherence tomography in photoreceptor degenerate rats. J Neurosci Methods. 2006 Mar 15; 151(2):186-93. PMID: 16129495.
      View in: PubMed
    31. Qiu G, Seiler MJ, Mui C, Arai S, Aramant RB, de Juan E, Sadda S. Photoreceptor differentiation and integration of retinal progenitor cells transplanted into transgenic rats. Exp Eye Res. 2005 Apr; 80(4):515-25. PMID: 15781279.
      View in: PubMed
    32. Seiler MJ, Sagdullaev BT, Woch G, Thomas BB, Aramant RB. Transsynaptic virus tracing from host brain to subretinal transplants. Eur J Neurosci. 2005 Jan; 21(1):161-72. PMID: 15654853.
      View in: PubMed
    33. Seiler MJ, Aramant RB. Transplantation of neuroblastic progenitor cells as a sheet preserves and restores retinal function. Semin Ophthalmol. 2005 Jan-Mar; 20(1):31-42. PMID: 15804842.
      View in: PubMed
    34. Thomas BB, Seiler MJ, Sadda SR, Coffey PJ, Aramant RB. Optokinetic test to evaluate visual acuity of each eye independently. J Neurosci Methods. 2004 Sep 30; 138(1-2):7-13. PMID: 15325106.
      View in: PubMed
    35. Aramant RB, Seiler MJ. Progress in retinal sheet transplantation. Prog Retin Eye Res. 2004 Sep; 23(5):475-94. PMID: 15302347.
      View in: PubMed
    36. Palanker D, Huie P, Vankov A, Aramant R, Seiler M, Fishman H, Marmor M, Blumenkranz M. Migration of retinal cells through a perforated membrane: implications for a high-resolution prosthesis. Invest Ophthalmol Vis Sci. 2004 Sep; 45(9):3266-70. PMID: 15326150.
      View in: PubMed
    37. Arai S, Thomas BB, Seiler MJ, Aramant RB, Qiu G, Mui C, de Juan E, Sadda SR. Restoration of visual responses following transplantation of intact retinal sheets in rd mice. Exp Eye Res. 2004 Sep; 79(3):331-41. PMID: 15336495.
      View in: PubMed
    38. Radtke ND, Aramant RB, Seiler MJ, Petry HM, Pidwell D. Vision change after sheet transplant of fetal retina with retinal pigment epithelium to a patient with retinitis pigmentosa. Arch Ophthalmol. 2004 Aug; 122(8):1159-65. PMID: 15302656.
      View in: PubMed
    39. Thomas BB, Seiler MJ, Sadda SR, Aramant RB. Superior colliculus responses to light - preserved by transplantation in a slow degeneration rat model. Exp Eye Res. 2004 Jul; 79(1):29-39. PMID: 15183098.
      View in: PubMed
    40. Qiu G, Seiler MJ, Arai S, Aramant RB, Sadda SR. Alternative culture conditions for isolation and expansion of retinal progenitor cells. Curr Eye Res. 2004 May; 28(5):327-36. PMID: 15287369.
      View in: PubMed
    41. Sagdullaev BT, Aramant RB, Seiler MJ, Woch G, McCall MA. Retinal transplantation-induced recovery of retinotectal visual function in a rodent model of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2003 Apr; 44(4):1686-95. PMID: 12657610.
      View in: PubMed
    42. Yang P, Seiler MJ, Aramant RB, Whittemore SR. In vitro isolation and expansion of human retinal progenitor cells. Exp Neurol. 2002 Sep; 177(1):326-31. PMID: 12429235.
      View in: PubMed
    43. Yang P, Seiler MJ, Aramant RB, Whittemore SR. Differential lineage restriction of rat retinal progenitor cells in vitro and in vivo. J Neurosci Res. 2002 Aug 15; 69(4):466-76. PMID: 12210840.
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    44. Aramant RB, Seiler MJ. Transplanted sheets of human retina and retinal pigment epithelium develop normally in nude rats. Exp Eye Res. 2002 Aug; 75(2):115-25. PMID: 12137757.
      View in: PubMed
    45. Radtke ND, Seiler MJ, Aramant RB, Petry HM, Pidwell DJ. Transplantation of intact sheets of fetal neural retina with its retinal pigment epithelium in retinitis pigmentosa patients. Am J Ophthalmol. 2002 Apr; 133(4):544-50. PMID: 11931789.
      View in: PubMed
    46. Aramant RB, Seiler MJ. Retinal transplantation--advantages of intact fetal sheets. Prog Retin Eye Res. 2002 Jan; 21(1):57-73. PMID: 11906811.
      View in: PubMed
    47. Woch G, Aramant RB, Seiler MJ, Sagdullaev BT, McCall MA. Retinal transplants restore visually evoked responses in rats with photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2001 Jun; 42(7):1669-76. PMID: 11381076.
      View in: PubMed
    48. Seiler MJ, Liu OL, Cooper NG, Callahan TL, Petry HM, Aramant RB. Selective photoreceptor damage in albino rats using continuous blue light. A protocol useful for retinal degeneration and transplantation research. Graefes Arch Clin Exp Ophthalmol. 2000 Jul; 238(7):599-607. PMID: 10955662.
      View in: PubMed
    49. Radtke ND, Aramant RB, Seiler M, Petry HM. Preliminary report: indications of improved visual function after retinal sheet transplantation in retinitis pigmentosa patients. Am J Ophthalmol. 1999 Sep; 128(3):384-7. PMID: 10511047.
      View in: PubMed
    50. Zrenner E, Stett A, Weiss S, Aramant RB, Guenther E, Kohler K, Miliczek KD, Seiler MJ, Haemmerle H. Can subretinal microphotodiodes successfully replace degenerated photoreceptors? Vision Res. 1999 Jul; 39(15):2555-67. PMID: 10396624.
      View in: PubMed
    51. Seiler MJ, Aramant RB, Ball SL. Photoreceptor function of retinal transplants implicated by light-dark shift of S-antigen and rod transducin. Vision Res. 1999 Jul; 39(15):2589-96. PMID: 10396627.
      View in: PubMed
    52. Aramant RB, Seiler MJ, Ball SL. Successful cotransplantation of intact sheets of fetal retina with retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1999 Jun; 40(7):1557-64. PMID: 10359338.
      View in: PubMed
    53. Seiler MJ, Aramant RB. Intact sheets of fetal retina transplanted to restore damaged rat retinas. Invest Ophthalmol Vis Sci. 1998 Oct; 39(11):2121-31. PMID: 9761291.
      View in: PubMed
    54. Aramant RB, Seiler MJ. Fiber and synaptic connections between embryonic retinal transplants and host retina. Exp Neurol. 1995 Jun; 133(2):244-55. PMID: 7649229.
      View in: PubMed
    55. Seiler MJ, Aramant RB, Bergström A. Co-transplantation of embryonic retina and retinal pigment epithelial cells to rabbit retina. Curr Eye Res. 1995 Mar; 14(3):199-207. PMID: 7796603.
      View in: PubMed
    56. Seiler MJ, Aramant RB. Transplantation of embryonic retinal donor cells labelled with BrdU or carrying a genetic marker to adult retina. Exp Brain Res. 1995; 105(1):59-66. PMID: 7589318.
      View in: PubMed
    57. Aramant RB, Seiler MJ. Human embryonic retinal cell transplants in athymic immunodeficient rat hosts. Cell Transplant. 1994 Nov-Dec; 3(6):461-74. PMID: 7881758.
      View in: PubMed
    58. Seiler MJ, Aramant RB. Photoreceptor and glial markers in human embryonic retina and in human embryonic retinal transplants to rat retina. Brain Res Dev Brain Res. 1994 Jul 15; 80(1-2):81-95. PMID: 7955364.
      View in: PubMed
    59. Zucker CL, Ehinger B, Seiler M, Aramant RB, Adolph AR. Ultrastructural circuitry in retinal cell transplants to rat retina. J Neural Transplant Plast. 1994 Jan-Mar; 5(1):17-29. PMID: 7819370.
      View in: PubMed
    60. Bergström A, Ehinger B, Wilke K, Zucker CL, Adolph AR, Aramant R, Seiler M. Transplantation of embryonic retina to the subretinal space in rabbits. Exp Eye Res. 1992 Jul; 55(1):29-37. PMID: 1397127.
      View in: PubMed
    61. Ehinger B, Bergström A, Seiler M, Aramant RB, Zucker CL, Gustavii B, Adolph AR. Ultrastructure of human retinal cell transplants with long survival times in rats. Exp Eye Res. 1991 Oct; 53(4):447-60. PMID: 1936181.
      View in: PubMed
    62. Aramant R, Seiler M. Cryopreservation and transplantation of immature rat retina into adult rat retina. Brain Res Dev Brain Res. 1991 Aug 19; 61(2):151-9. PMID: 1752038.
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    63. Seiler M, Aramant RB, Ehinger B, Adolph AR. Transplantation of embryonic retina to adult retina in rabbits. Exp Eye Res. 1990 Aug; 51(2):225-8. PMID: 2387338.
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    64. Aramant R, Seiler M, Ehinger B, Bergström A, Adolph AR, Turner JE. Neuronal markers in rat retinal grafts. Brain Res Dev Brain Res. 1990 Apr 01; 53(1):47-61. PMID: 1972041.
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    65. Aramant R, Seiler M, Ehinger B, Bergström A, Gustavii B, Brundin P, Adolph AR. Transplantation of human embryonic retina to adult rat retina. Restor Neurol Neurosci. 1990 Jan 01; 2(1):9-22. PMID: 21551868.
      View in: PubMed
    66. Seiler M, Turner JE. The activities of host and graft glial cells following retinal transplantation into the lesioned adult rat eye: developmental expression of glial markers. Brain Res. 1988 Sep 01; 471(1):111-22. PMID: 3064877.
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    67. Aramant R, Seiler M, Turner JE. Donor age influences on the success of retinal grafts to adult rat retina. Invest Ophthalmol Vis Sci. 1988 Mar; 29(3):498-503. PMID: 3343107.
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    68. Turner JE, Seiler M, Aramant R, Blair JR. Embryonic retinal grafts transplanted into the lesioned adult rat retina. Prog Brain Res. 1988; 78:131-9. PMID: 3247418.
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    69. Turner JE, Blair JR, Seiler M, Aramant R, Laedtke TW, Chappell ET, Clarkson L. Retinal transplants and optic nerve bridges: possible strategies for visual recovery as a result of trauma or disease. Int Rev Neurobiol. 1988; 29:281-308. PMID: 3042666.
      View in: PubMed
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