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Seiler, Magdalene J

Title(s)Assistant Professor In Residence, Physical Medicine and Rehabilitation
Phone(949) 824-2037
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    Collapse Education and Training
    Ludwig-Maximilians-University, Munich, GermanyDiploma06/1982Zoology
    Max-Planck-Institute for Neurochemistry, Ludwig-Maximilians-University , Martinsried & Munich, GermanyPh.D.12/1985Neurochemistry

    Collapse Overview 
    Collapse Overview
    Research Focus: Retinal sheet transplantation and demonstration of vision restoration in rat models of retinal degeneration and ultimately in retinal degeneration patients. See also lab website at http://sites.uci.edu/seilerlab/magdalenejseiler
    Detail on Research
    My primary scientific interests are in retinal transplantation, retinal degeneration models, retinal development, stem cells and neurotrophic factors. Along with my colleague, Dr. Robert Aramant, I have developed and refined a unique procedure of retinal sheet transplantation which has demonstrated improvement of visual responses in four different retinal degeneration models (RCS rats, rd mice, rhodopsin S334ter-3 and -5 rat models of fast and slow retinal degeneration). This lead to Phase I and II clinical trials that showed visual improvement in RP and AMD patients.
    In 2014, I received a 3-year Early Translational grant from CIRM with the goal of developing human embryonic stem cells to transplantable 3-D sheets of retinal progenitor cells for vision restoration. We have now demonstrated that stem-cell derived retina can improve visual responses in 2 different immunodeficient rat models with retinal degeneration that do not reject human cells. This research was done in collaboration with Dr. Hans Keirstead (at UC Irvine until 2014; now CEO of AIVITA Biomedical, Irvine). In 2018, I received a 4.7 million TRAN1 grant (2.5 years) entitled “Morphological and functional integration of stem cell derived retina organoid sheets into degenerating retina models.” that will develop this application towards a treatment for Retinitis Pigmentosa (see press release June 2018)

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Foik AT, Lean GA, Scholl LR, McLelland BT, Mathur A, Aramant RB, Seiler MJ, Lyon DC. Detailed Visual Cortical Responses Generated by Retinal Sheet Transplants in Rats with Severe Retinal Degeneration. J Neurosci. 2018 Dec 12; 38(50):10709-10724. PMID: 30396913.
      View in: PubMed
    2. Thomas BB, Zhu D, Lin TC, Kim YC, Seiler MJ, Martinez-Camarillo JC, Lin B, Shad Y, Hinton DR, Humayun MS. A new immunodeficient retinal dystrophic rat model for transplantation studies using human-derived cells. Graefes Arch Clin Exp Ophthalmol. 2018 Nov; 256(11):2113-2125. PMID: 30215097.
      View in: PubMed
    3. Lin B, McLelland BT, Mathur A, Aramant RB, Seiler MJ. Sheets of human retinal progenitor transplants improve vision in rats with severe retinal degeneration. Exp Eye Res. 2018 09; 174:13-28. PMID: 29782826.
      View in: PubMed
    4. McLelland BT, Lin B, Mathur A, Aramant RB, Thomas BB, Nistor G, Keirstead HS, Seiler MJ. Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats. Invest Ophthalmol Vis Sci. 2018 May 01; 59(6):2586-2603. PMID: 29847666.
      View in: PubMed
    5. Lin TC, Seiler MJ, Zhu D, Falabella P, Hinton DR, Clegg DO, Humayun MS, Thomas BB. Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models. Stem Cells Int. 2017; 2017:9428176. PMID: 28928775.
      View in: PubMed
    6. Seiler MJ. hESC-derived photoreceptors survive and integrate better in immunodeficient retina. Stem Cell Investig. 2017; 4:70. PMID: 28920063.
      View in: PubMed
    7. Seiler MJ, Lin RE, McLelland BT, Mathur A, Lin B, Sigman J, De Guzman AT, Kitzes LM, Aramant RB, Thomas BB. Vision Recovery and Connectivity by Fetal Retinal Sheet Transplantation in an Immunodeficient Retinal Degenerate Rat Model. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):614-630. PMID: 28129425.
      View in: PubMed
    8. Seiler MJ, Aramant RB, Jones MK, Ferguson DL, Bryda EC, Keirstead HS. A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression. Graefes Arch Clin Exp Ophthalmol. 2014 Jul; 252(7):1079-92. PMID: 24817311; PMCID: PMC4374984.
      View in: PubMed, PubMed Central
    9. Seiler MJ, Aramant RB. Cell replacement and visual restoration by retinal sheet transplants. Prog Retin Eye Res. 2012 Nov; 31(6):661-87. PMID: 22771454; PMCID: PMC3472113.
      View in: PubMed, PubMed Central
    10. Harness JV, Turovets NA, Seiler MJ, Nistor G, Altun G, Agapova LS, Ferguson D, Laurent LC, Loring JF, Keirstead HS. Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells. PLoS One. 2011 Jan 07; 6(1):e14499. PMID: 21249129; PMCID: PMC3017547.
      View in: PubMed, PubMed Central
    11. Yang PB, Seiler MJ, Aramant RB, Yan F, Mahoney MJ, Kitzes LM, Keirstead HS. Trophic factors GDNF and BDNF improve function of retinal sheet transplants. Exp Eye Res. 2010 Nov; 91(5):727-38. PMID: 20804751; PMCID: PMC4564299.
      View in: PubMed, PubMed Central
    12. Nistor G, Seiler MJ, Yan F, Ferguson D, Keirstead HS. Three-dimensional early retinal progenitor 3D tissue constructs derived from human embryonic stem cells. J Neurosci Methods. 2010 Jun 30; 190(1):63-70. PMID: 20447416.
      View in: PubMed
    13. Seiler MJ, Rao B, Aramant RB, Yu L, Wang Q, Kitayama E, Pham S, Yan F, Chen Z, Keirstead HS. Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats. J Neurosci Methods. 2010 May 15; 188(2):250-7. PMID: 20219535; PMCID: PMC2855654.
      View in: PubMed, PubMed Central
    14. Seiler MJ, Aramant RB, Seeliger MW, Bragadottir R, Mahoney M, Narfstrom K. Functional and structural assessment of retinal sheet allograft transplantation in feline hereditary retinal degeneration. Vet Ophthalmol. 2009 May-Jun; 12(3):158-69. PMID: 19392875.
      View in: PubMed
    15. Seiler MJ, Thomas BB, Chen Z, Wu R, Sadda SR, Aramant RB. Retinal transplants restore visual responses: trans-synaptic tracing from visually responsive sites labels transplant neurons. Eur J Neurosci. 2008 Jul; 28(1):208-20. PMID: 18662343.
      View in: PubMed
    16. Radtke ND, Aramant RB, Petry HM, Green PT, Pidwell DJ, Seiler MJ. Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium. Am J Ophthalmol. 2008 Aug; 146(2):172-182. PMID: 18547537.
      View in: PubMed
    17. Leung KW, Liu M, Xu X, Seiler MJ, Barnstable CJ, Tombran-Tink J. Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1221-31. PMID: 18326752.
      View in: PubMed
    18. Seiler MJ, Thomas BB, Chen Z, Arai S, Chadalavada S, Mahoney MJ, Sadda SR, Aramant RB. BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function. Exp Eye Res. 2008 Jan; 86(1):92-104. PMID: 17983616; PMCID: PMC3074939.
      View in: PubMed, PubMed Central
    19. Peng Q, Thomas BB, Aramant RB, Chen Z, Sadda SR, Seiler MJ. Structure and function of embryonic rat retinal sheet transplants. Curr Eye Res. 2007 Sep; 32(9):781-9. PMID: 17882711.
      View in: PubMed
    20. Thomas BB, Seiler MJ, Aramant RB, Samant D, Qiu G, Vyas N, Arai S, Chen Z, Sadda SR. Visual functional effects of constant blue light in a retinal degenerate rat model. Photochem Photobiol. 2007 May-Jun; 83(3):759-65. PMID: 17115798.
      View in: PubMed
    21. Qiu G, Seiler MJ, Thomas BB, Wu K, Radosevich M, Sadda SR. Revisiting nestin expression in retinal progenitor cells in vitro and after transplantation in vivo. Exp Eye Res. 2007 Jun; 84(6):1047-59. PMID: 17451684.
      View in: PubMed
    22. Thomas BB, Samant DM, Seiler MJ, Aramant RB, Sheikholeslami S, Zhang K, Chen Z, Sadda SR. Behavioral evaluation of visual function of rats using a visual discrimination apparatus. J Neurosci Methods. 2007 May 15; 162(1-2):84-90. PMID: 17289151; PMCID: PMC3074943.
      View in: PubMed, PubMed Central
    23. Thomas BB, Aramant RB, Sadda SR, Seiler MJ. Retinal transplantation. A treatment strategy for retinal degenerative diseases. Adv Exp Med Biol. 2006; 572:367-76. PMID: 17249598.
      View in: PubMed
    24. Thomas BB, Aramant RB, Sadda SR, Seiler MJ. Light response differences in the superior colliculus of albino and pigmented rats. Neurosci Lett. 2005 Sep 09; 385(2):143-7. PMID: 15950381.
      View in: PubMed
    25. Thomas BB, Arai S, Ikai Y, Qiu G, Chen Z, Aramant RB, Sadda SR, Seiler MJ. Retinal transplants evaluated by optical coherence tomography in photoreceptor degenerate rats. J Neurosci Methods. 2006 Mar 15; 151(2):186-93. PMID: 16129495.
      View in: PubMed
    26. Qiu G, Seiler MJ, Mui C, Arai S, Aramant RB, de Juan E, Sadda S. Photoreceptor differentiation and integration of retinal progenitor cells transplanted into transgenic rats. Exp Eye Res. 2005 Apr; 80(4):515-25. PMID: 15781279.
      View in: PubMed
    27. Seiler MJ, Aramant RB. Transplantation of neuroblastic progenitor cells as a sheet preserves and restores retinal function. Semin Ophthalmol. 2005 Jan-Mar; 20(1):31-42. PMID: 15804842.
      View in: PubMed
    28. Seiler MJ, Sagdullaev BT, Woch G, Thomas BB, Aramant RB. Transsynaptic virus tracing from host brain to subretinal transplants. Eur J Neurosci. 2005 Jan; 21(1):161-72. PMID: 15654853.
      View in: PubMed
    29. Thomas BB, Seiler MJ, Sadda SR, Coffey PJ, Aramant RB. Optokinetic test to evaluate visual acuity of each eye independently. J Neurosci Methods. 2004 Sep 30; 138(1-2):7-13. PMID: 15325106.
      View in: PubMed
    30. Aramant RB, Seiler MJ. Progress in retinal sheet transplantation. Prog Retin Eye Res. 2004 Sep; 23(5):475-94. PMID: 15302347.
      View in: PubMed
    31. Palanker D, Huie P, Vankov A, Aramant R, Seiler M, Fishman H, Marmor M, Blumenkranz M. Migration of retinal cells through a perforated membrane: implications for a high-resolution prosthesis. Invest Ophthalmol Vis Sci. 2004 Sep; 45(9):3266-70. PMID: 15326150.
      View in: PubMed
    32. Radtke ND, Aramant RB, Seiler MJ, Petry HM, Pidwell D. Vision change after sheet transplant of fetal retina with retinal pigment epithelium to a patient with retinitis pigmentosa. Arch Ophthalmol. 2004 Aug; 122(8):1159-65. PMID: 15302656.
      View in: PubMed
    33. Thomas BB, Seiler MJ, Sadda SR, Aramant RB. Superior colliculus responses to light - preserved by transplantation in a slow degeneration rat model. Exp Eye Res. 2004 Jul; 79(1):29-39. PMID: 15183098.
      View in: PubMed
    34. Sagdullaev BT, Aramant RB, Seiler MJ, Woch G, McCall MA. Retinal transplantation-induced recovery of retinotectal visual function in a rodent model of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2003 Apr; 44(4):1686-95. PMID: 12657610.
      View in: PubMed
    35. Yang P, Seiler MJ, Aramant RB, Whittemore SR. In vitro isolation and expansion of human retinal progenitor cells. Exp Neurol. 2002 Sep; 177(1):326-31. PMID: 12429235.
      View in: PubMed
    36. Yang P, Seiler MJ, Aramant RB, Whittemore SR. Differential lineage restriction of rat retinal progenitor cells in vitro and in vivo. J Neurosci Res. 2002 Aug 15; 69(4):466-76. PMID: 12210840.
      View in: PubMed
    37. Aramant RB, Seiler MJ. Transplanted sheets of human retina and retinal pigment epithelium develop normally in nude rats. Exp Eye Res. 2002 Aug; 75(2):115-25. PMID: 12137757.
      View in: PubMed
    38. Radtke ND, Seiler MJ, Aramant RB, Petry HM, Pidwell DJ. Transplantation of intact sheets of fetal neural retina with its retinal pigment epithelium in retinitis pigmentosa patients. Am J Ophthalmol. 2002 Apr; 133(4):544-50. PMID: 11931789.
      View in: PubMed
    39. Aramant RB, Seiler MJ. Retinal transplantation--advantages of intact fetal sheets. Prog Retin Eye Res. 2002 Jan; 21(1):57-73. PMID: 11906811.
      View in: PubMed
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