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Zhigang David Luo

Title(s)Recall Faculty, Anesthesiology and Perioperative Care
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-7469
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    Collapse Biography 
    Collapse education and training
    Guangzhou Medical University, Guangzhou, ChinaMD1984
    University at Buffalo, The State University of New Year, New YorkPhD1993Biochemical Pharmacology
    University of California, San Digeo, San Diego1993Postgraduate Research

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Validation of blocking TSP4/Cava2d1 interaction as a new target for neuropathic pain
    NIH R01DE029202Sep 24, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Nanoparticle mediated in vivo cell-type specific drug delivery for pain relief
    NIH/NINR R21NR013756Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    A novel pathway mediating the development of chronic orofacial neuropathic pain
    NIH R01DE021847Apr 7, 2011 - Feb 28, 2017
    Role: Principal Investigator
    Mechanism of Calcium Channel Cava2d1 Protein Mediated Neuropathic Pain
    NIH/NINDS R01NS064341Feb 1, 2010 - Jan 31, 2015
    Role: Principal Investigator
    Defining Target Contribution to Orofacial Pain by Antisense Oligonucleotides
    NIH/NIDCR R21DE019298Aug 1, 2008 - Jul 31, 2011
    Role: Principal Investigator
    Target Genes of Inflammatory Temporomandibular Pain
    NIH/NIDCR R21DE018564Jul 1, 2007 - Jun 30, 2010
    Role: Principal Investigator
    Searching for Genes Responsibile for Neuropathic Pain
    NIH/NIDCR R21DE014545May 1, 2003 - Apr 30, 2006
    Role: Principal Investigator
    CALCIUM CHANNEL SUBUNIT REGULATION AND NEUROPATHIC PAIN
    NIH/NINDS R01NS040135Dec 25, 2000 - Nov 30, 2006
    Role: Principal Investigator
    NEURONAL NITRIC OXIDE SYNTHASE IN NEUROPATHIC PAIN
    NIH/NIDCR R03DE013270Feb 1, 2000 - Jan 31, 2002
    Role: Principal Investigator
    ACETYLCHOLINESTERASE EXPRESSION AND HEART TRABECULATION
    NIH/NHLBI F32HL009848Dec 31, 1997
    Role: Principal Investigator
    Rehabilitation Medicine Scientist Training (RMST) Program
    NIH K12HD001097Jul 1, 1995 - Feb 28, 2018
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Building community through data: the value of a researcher driven open science ecosystem. Pain Med. 2025 Jun 01; 26(6):295-298. Adams MCB, Bann CM, Bayman EO, Chao M, Hergenroeder GW, Knott C, Lindquist MA, Luo ZD, Martin R, Martone ME, McCarthy J, McCumber M, Meropol SB, Ridenour TA, Saavedra LM, Sarker A, Anstrom KJ, Thompson WK. PMID: 39836639; PMCID: PMC12130680.
      View in: PubMed   Mentions: 4     Fields:    
    2. Pathophysiological roles of thrombospondin-4 in disease development. Semin Cell Dev Biol. 2024 Mar 01; 155(Pt B):66-73. Genaro K, Luo ZD. PMID: 37391348; PMCID: PMC10753034.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Functional Reorganization of Local Circuit Connectivity in Superficial Spinal Dorsal Horn with Neuropathic Pain States. eNeuro. 2019 Sep/Oct; 6(5). Gong N, Hagopian G, Holmes TC, Luo ZD, Xu X. PMID: 31533959; PMCID: PMC6787342.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    4. The EGF-LIKE domain of thrombospondin-4 is a key determinant in the development of pain states due to increased excitatory synaptogenesis. J Biol Chem. 2018 Oct 19; 293(42):16453-16463. Park JF, Yu YP, Gong N, Trinh VN, Luo ZD. PMID: 30194282; PMCID: PMC6200931.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    5. Gabapentin prevents synaptogenesis between sensory and spinal cord neurons induced by thrombospondin-4 acting on pre-synaptic Cav a2 d1 subunits and involving T-type Ca2+ channels. Br J Pharmacol. 2018 Jun; 175(12):2348-2361. Yu YP, Gong N, Kweon TD, Vo B, Luo ZD. PMID: 29338087; PMCID: PMC5980510.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    6. Injury-induced maladaptation and dysregulation of calcium channel a2 d subunit proteins and its contribution to neuropathic pain development. Br J Pharmacol. 2018 Jun; 175(12):2231-2243. Gong N, Park J, Luo ZD. PMID: 28646556; PMCID: PMC5980513.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    7. Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons. Neuropharmacology. 2017 May 01; 117:292-304. Guo Y, Zhang Z, Wu HE, Luo ZD, Hogan QH, Pan B. PMID: 28232180; PMCID: PMC5414309.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    8. Epileptiform activity and behavioral arrests in mice overexpressing the calcium channel subunit a2d-1. Neurobiol Dis. 2017 Jun; 102:70-80. Faria LC, Gu F, Parada I, Barres B, Luo ZD, Prince DA. PMID: 28193459.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    9. Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity. Neuron. 2016 Oct 05; 92(1):160-173. Sun Y, Ikrar T, Davis MF, Gong N, Zheng X, Luo ZD, Lai C, Mei L, Holmes TC, Gandhi SP, Xu X. PMID: 27641496; PMCID: PMC5310354.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    10. Thrombospondin-4 divergently regulates voltage-gated Ca2+ channel subtypes in sensory neurons after nerve injury. Pain. 2016 Sep; 157(9):2068-2080. Pan B, Guo Y, Wu HE, Park J, Trinh VN, Luo ZD, Hogan QH. PMID: 27168360; PMCID: PMC4988923.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    11. Central Mechanisms Mediating Thrombospondin-4-induced Pain States. J Biol Chem. 2016 Jun 17; 291(25):13335-48. Park J, Yu YP, Zhou CY, Li KW, Wang D, Chang E, Kim DS, Vo B, Zhang X, Gong N, Sharp K, Steward O, Vitko I, Perez-Reyes E, Eroglu C, Barres B, Zaucke F, Feng G, Luo ZD. PMID: 27129212; PMCID: PMC4933243.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    12. Synaptic ultrastructure changes in trigeminocervical complex posttrigeminal nerve injury. J Comp Neurol. 2016 Feb 01; 524(2):309-22. Park J, Trinh VN, Sears-Kraxberger I, Li KW, Steward O, Luo ZD. PMID: 26132987; PMCID: PMC4675675.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. Thrombospondin-4 and excitatory synaptogenesis promote spinal sensitization after painful mechanical joint injury. Exp Neurol. 2015 Feb; 264:111-20. Crosby ND, Zaucke F, Kras JV, Dong L, Luo ZD, Winkelstein BA. PMID: 25483397; PMCID: PMC4324021.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    14. Calcium channel α2δ1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis. J Biol Chem. 2014 Mar 07; 289(10):7025-7037. Li KW, Yu YP, Zhou C, Kim DS, Lin B, Sharp K, Steward O, Luo ZD. PMID: 24459143; PMCID: PMC3945363.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    15. A novel analgesic isolated from a traditional Chinese medicine. Curr Biol. 2014 Jan 20; 24(2):117-123. Zhang Y, Wang C, Wang L, Parks GS, Zhang X, Guo Z, Ke Y, Li KW, Kim MK, Vo B, Borrelli E, Ge G, Yang L, Wang Z, Garcia-Fuster MJ, Luo ZD, Liang X, Civelli O. PMID: 24388848; PMCID: PMC3912990.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    16. Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. J Neurosci. 2012 Jun 27; 32(26):8977-87. Kim DS, Li KW, Boroujerdi A, Peter Yu Y, Zhou CY, Deng P, Park J, Zhang X, Lee J, Corpe M, Sharp K, Steward O, Eroglu C, Barres B, Zaucke F, Xu ZC, Luo ZD. PMID: 22745497; PMCID: PMC3408211.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    17. Exposure of the dorsal root ganglion to pulsed radiofrequency current in a neuropathic pain model of peripheral nerve injury. Methods Mol Biol. 2012; 851:275-84. Perret D, Kim DS, Li KW, Luo ZD. PMID: 22351099.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    18. A rat chronic pain model of spinal cord contusion injury. Methods Mol Biol. 2012; 851:195-203. Sharp K, Boroujerdi A, Steward O, Luo ZD. PMID: 22351092.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    19. Advancements in pain research. Methods Mol Biol. 2012; 851:1-8. Luo ZD. PMID: 22351079.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Calcium channel functions in pain processing. Channels (Austin). 2010; 4(6):510-7. Park J, Luo ZD. PMID: 21150297; PMCID: PMC3052250.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    21. Targeting voltage-gated calcium channels for neuropathic pain management. Neurotherapeutics. 2009 Oct; 6(4):679-92. Perret D, Luo ZD. PMID: 19789072; PMCID: PMC2755636.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    22. Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acidic protein in maintenance of pain behaviors [corrected]. Pain. 2009 May; 143(1-2):114-22. Kim DS, Figueroa KW, Li KW, Boroujerdi A, Yolo T, Luo ZD. PMID: 19307059; PMCID: PMC2743568.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    23. Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity. Mol Pain. 2009 Feb 12; 5:6. Nguyen D, Deng P, Matthews EA, Kim DS, Feng G, Dickenson AH, Xu ZC, Luo ZD. PMID: 19216737; PMCID: PMC2646710.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    24. Impaired pain sensation in mice lacking prokineticin 2. Mol Pain. 2006 Nov 15; 2:35. Hu WP, Zhang C, Li JD, Luo ZD, Amadesi S, Bunnett N, Zhou QY. PMID: 17107623; PMCID: PMC1660571.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    25. Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation. Pain. 2006 Nov; 125(1-2):20-34. Li CY, Zhang XL, Matthews EA, Li KW, Kurwa A, Boroujerdi A, Gross J, Gold MS, Dickenson AH, Feng G, Luo ZD. PMID: 16764990; PMCID: PMC1635965.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    26. Spinal dorsal horn calcium channel alpha2delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia. J Neurosci. 2004 Sep 29; 24(39):8494-9. Li CY, Song YH, Higuera ES, Luo ZD. PMID: 15456823; PMCID: PMC1635787.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    27. Mechanistic dissection of pain: from DNA to animal models. Methods Mol Med. 2004; 99:1-10. Luo ZD. PMID: 15131324.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    28. Inhibition of branched-chain alpha-keto acid dehydrogenase kinase and Sln1 yeast histidine kinase by the antifungal antibiotic radicicol. Mol Pharmacol. 2002 Aug; 62(2):289-96. Besant PG, Lasker MV, Bui CD, Turck CW. PMID: 12130680.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    29. Nitric oxide and vascular responses in Type I diabetes. Diabetologia. 2000 Feb; 43(2):137-47. Chan NN, Vallance P, Colhoun HM. PMID: 10753034.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    30. Location and chemical synthesis of a pre-S gene coded immunodominant epitope of hepatitis B virus. Science. 1984 Apr 27; 224(4647):392-5. Neurath AR, Kent SB, Strick N. PMID: 6200931.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCellsPHPublic Health
    31. Peritoneal clearance of bacteria in the tumor-bearing mouse. J Surg Res. 1981 Jun; 30(6):576-82. Bagley DH, Herlihy E, Lytton B. PMID: 6787342.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    32. [On the treatment of the neonatal umbilicus]. Landarzt. 1966 Dec 10; 42(34):1546-7. Müller H. PMID: 5980510.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
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