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Subramanian, Veedamali S

TitleAssociate Professor In Residence
InstitutionUniversity of California, Irvine
DepartmentMedicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-5142
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    Collapse Research 
    Collapse Research Activities and Funding
    Physiology/pathophysiology of intestinal vitC uptake: Cell/molecular mechanisms
    NIH/NIDDK R01DK107474Dec 22, 2015 - Nov 30, 2020
    Role: Principal Investigator
    Role of Rab proteins in hSVCT1 cell biology in intestinal epithelial cells
    NIH/NIDDK R03DK084094Aug 1, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Cell Biology of Human Vit C Transporters in Liver Cells
    NIH/NIDDK K01DK071538Apr 10, 2006 - Mar 31, 2011
    Role: Principal Investigator
    Cell Biology of Human Thiamine Transporters
    NIH/NIDDK F32DK063750Feb 4, 2003 - Feb 3, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Subramenium GA, Subai S, Marchant JS, Said HM, Subramanian VS. Enterotoxigenic Escherichia coli (ETEC) heat labile enterotoxin inhibits intestinal ascorbic acid uptake via a cAMP-dependent NF-?B mediated pathway. Am J Physiol Gastrointest Liver Physiol. 2018 Oct 04. PMID: 30285481.
      View in: PubMed
    2. Subramanian VS, Sabui S, Heskett CW, Said HM. Sodium Butyrate Enhances Intestinal Riboflavin Uptake via Induction of Expression of Riboflavin Transporter-3 (RFVT3). Dig Dis Sci. 2018 Oct 01. PMID: 30276569.
      View in: PubMed
    3. Anandam KY, Alwan OA, Subramanian VS, Srinivasan P, Kapadia R, Said HM. Effect of the pro-inflammatory cytokine TNF-a on intestinal riboflavin uptake: Inhibition mediated via transcriptional mechanism(s). Am J Physiol Cell Physiol. 2018 Aug 29. PMID: 30156861.
      View in: PubMed
    4. Subramanian VS, Sabui S, Subramenium GA, Marchant JS, Said HM. Tumor Necrosis Factor alpha (TNF-a) reduces intestinal vitamin C uptake: a role for NF-?B mediated signaling. Am J Physiol Gastrointest Liver Physiol. 2018 Apr 06. PMID: 29631379.
      View in: PubMed
    5. Subramanian VS, Nabokina SM, Lin-Moshier Y, Marchant JS, Said HM. Correction: Mitochondrial Uptake of Thiamin Pyrophosphate: Physiological and Cell Biological Aspects. PLoS One. 2017; 12(10):e0186541. PMID: 29020070.
      View in: PubMed
    6. Subramanian VS, Sabui S, Moradi H, Marchant JS, Said HM. Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated via transcriptional mechanisms. Biochim Biophys Acta. 2018 02; 1860(2):556-565. PMID: 29030247.
      View in: PubMed
    7. Nabokina SM, Inoue K, Subramanian VS, Valle JE, Yuasa H, Said HM. Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter. J Biol Chem. 2017 10 06; 292(40):16526. PMID: 28986434.
      View in: PubMed
    8. Anandam KY, Srinivasan P, Subramanian VS, Said HM. Molecular mechanisms involved in the adaptive regulation of the colonic thiamin pyrophosphate uptake process. Am J Physiol Cell Physiol. 2017 Dec 01; 313(6):C655-C663. PMID: 28931541.
      View in: PubMed
    9. Lakhan R, Subramanian VS, Said HM. Role of MicroRNA-423-5p in posttranscriptional regulation of the intestinal riboflavin transporter-3. Am J Physiol Gastrointest Liver Physiol. 2017 Dec 01; 313(6):G589-G598. PMID: 28912250.
      View in: PubMed
    10. Sabui S, Subramanian VS, Kapadia R, Said HM. Adaptive regulation of pancreatic acinar mitochondrial thiamin pyrophosphate uptake process: possible involvement of epigenetic mechanism(s). Am J Physiol Gastrointest Liver Physiol. 2017 Nov 01; 313(5):G448-G455. PMID: 28729247.
      View in: PubMed
    11. Subramanian VS, Sabui S, Teafatiller T, Bohl JA, Said HM. Structure/functional aspects of the human riboflavin transporter-3 (SLC52A3): role of the predicted glycosylation and substrate-interacting sites. Am J Physiol Cell Physiol. 2017 Aug 01; 313(2):C228-C238. PMID: 28637675.
      View in: PubMed
    12. Subramanian VS, Srinivasan P, Wildman AJ, Marchant JS, Said HM. Molecular mechanism(s) involved in differential expression of vitamin C transporters along the intestinal tract. Am J Physiol Gastrointest Liver Physiol. 2017 Apr 01; 312(4):G340-G347. PMID: 27932501.
      View in: PubMed
    13. Subramanian VS, Constantinescu AR, Benke PJ, Said HM. Mutations in SLC5A6 associated with brain, immune, bone, and intestinal dysfunction in a young child. Hum Genet. 2017 02; 136(2):253-261. PMID: 27904971.
      View in: PubMed
    14. Udhayabanu T, Subramanian VS, Teafatiller T, Gowda VK, Raghavan VS, Varalakshmi P, Said HM, Ashokkumar B. SLC52A2 [p.P141T] and SLC52A3 [p.N21S] causing Brown-Vialetto-Van Laere Syndrome in an Indian patient: First genetically proven case with mutations in two riboflavin transporters. Clin Chim Acta. 2016 Nov 01; 462:210-214. PMID: 27702554.
      View in: PubMed
    15. Sassoon CS, Zhu E, Fang L, Subramanian VS, Said HM. Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis. Crit Care Med. 2016 Sep; 44(9):e875-81. PMID: 27065466; PMCID: PMC4987227.
    16. Sabui S, Subramanian VS, Kapadia R, Said HM. Structure-function characterization of the human mitochondrial thiamin pyrophosphate transporter (hMTPPT; SLC25A19): Important roles for Ile(33), Ser(34), Asp(37), His(137) and Lys(291). Biochim Biophys Acta. 2016 08; 1858(8):1883-90. PMID: 27188525; PMCID: PMC4900926 [Available on 08/01/17].
    17. Subramanian VS, Srinivasan P, Said HM. Uptake of ascorbic acid by pancreatic acinar cells is negatively impacted by chronic alcohol exposure. Am J Physiol Cell Physiol. 2016 Jul 01; 311(1):C129-35. PMID: 27122159; PMCID: PMC4967129 [Available on 07/01/17].
    18. Nabokina SM, Subramanian VS, Said HM. The human colonic thiamine pyrophosphate transporter (hTPPT) is a glycoprotein and N-linked glycosylation is important for its function. Biochim Biophys Acta. 2016 Apr; 1858(4):866-71. PMID: 26828122; PMCID: PMC4779673 [Available on 04/01/17].
    19. Subramanian VS, Lambrecht N, Lytle C, Said HM. Conditional (intestinal-specific) knockout of the riboflavin transporter-3 (RFVT-3) impairs riboflavin absorption. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 15; 310(4):G285-93. PMID: 26660539; PMCID: PMC4754740 [Available on 02/15/17].
    20. Srinivasan P, Thrower EC, Loganathan G, Balamurugan AN, Subramanian VS, Gorelick FS, Said HM. Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells. PLoS One. 2015; 10(12):e0143575. PMID: 26633299; PMCID: PMC4669105.
    21. Manimaran P, Subramanian VS, Karthi S, Gandhimathi K, Varalakshmi P, Ganesh R, Rathinavel A, Said HM, Ashokkumar B. Novel nonsense mutation (p.Ile411Metfs*12) in the SLC19A2 gene causing Thiamine Responsive Megaloblastic Anemia in an Indian patient. Clin Chim Acta. 2016 Jan 15; 452:44-9. PMID: 26549656.
      View in: PubMed
    22. Subramanian VS, Ghosal A, Kapadia R, Nabokina SM, Said HM. Molecular Mechanisms Mediating the Adaptive Regulation of Intestinal Riboflavin Uptake Process. PLoS One. 2015; 10(6):e0131698. PMID: 26121134; PMCID: PMC4484800.
    23. Subramanian VS, Kapadia R, Ghosal A, Said HM. Identification of residues/sequences in the human riboflavin transporter-2 that is important for function and cell biology. Nutr Metab (Lond). 2015; 12:13. PMID: 25798182; PMCID: PMC4367879.
    24. Srinivasan P, Subramanian VS, Said HM. Mechanisms involved in the inhibitory effect of chronic alcohol exposure on pancreatic acinar thiamin uptake. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 01; 306(7):G631-9. PMID: 24525018; PMCID: PMC3962591.
    25. Nabokina SM, Inoue K, Subramanian VS, Valle JE, Yuasa H, Said HM. Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter. J Biol Chem. 2014 Feb 14; 289(7):4405-16. PMID: 24379411; PMCID: PMC3924303.
    26. Subramanian VS, Nabokina SM, Said HM. Association of TM4SF4 with the human thiamine transporter-2 in intestinal epithelial cells. Dig Dis Sci. 2014 Mar; 59(3):583-90. PMID: 24282057; PMCID: PMC3943980.
    27. Srinivasan P, Subramanian VS, Said HM. Effect of the cigarette smoke component, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), on physiological and molecular parameters of thiamin uptake by pancreatic acinar cells. PLoS One. 2013; 8(11):e78853. PMID: 24244374; PMCID: PMC3820693.
    28. Subramanian VS, Nabokina SM, Lin-Moshier Y, Marchant JS, Said HM. Mitochondrial uptake of thiamin pyrophosphate: physiological and cell biological aspects. PLoS One. 2013; 8(8):e73503. PMID: 24023687; PMCID: PMC3758298.
    29. Nabokina SM, Subramanian VS, Valle JE, Said HM. Adaptive regulation of human intestinal thiamine uptake by extracellular substrate level: a role for THTR-2 transcriptional regulation. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G593-9. PMID: 23989004; PMCID: PMC3798731.
    30. Subramanian VS, Subramanya SB, Ghosal A, Said HM. Chronic alcohol feeding inhibits physiological and molecular parameters of intestinal and renal riboflavin transport. Am J Physiol Cell Physiol. 2013 Sep; 305(5):C539-46. PMID: 23804199; PMCID: PMC3761153.
    31. Kumar JS, Subramanian VS, Kapadia R, Kashyap ML, Said HM. Mammalian colonocytes possess a carrier-mediated mechanism for uptake of vitamin B3 (niacin): studies utilizing human and mouse colonic preparations. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 01; 305(3):G207-13. PMID: 23744738; PMCID: PMC3742858.
    32. Subramanian VS, Nabokina SM, Patton JR, Marchant JS, Moradi H, Said HM. Glyoxalate reductase/hydroxypyruvate reductase interacts with the sodium-dependent vitamin C transporter-1 to regulate cellular vitamin C homeostasis. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15; 304(12):G1079-86. PMID: 23599041; PMCID: PMC3680717.
    33. Subramanian VS, Ghosal A, Subramanya SB, Lytle C, Said HM. Differentiation-dependent regulation of intestinal vitamin B(2) uptake: studies utilizing human-derived intestinal epithelial Caco-2 cells and native rat intestine. Am J Physiol Gastrointest Liver Physiol. 2013 Apr 15; 304(8):G741-8. PMID: 23413253; PMCID: PMC3625875.
    34. Subramanian VS, Subramanya SB, Ghosal A, Marchant JS, Harada A, Said HM. Modulation of function of sodium-dependent vitamin C transporter 1 (SVCT1) by Rab8a in intestinal epithelial cells: studies utilizing Caco-2 cells and Rab8a knockout mice. Dig Dis Sci. 2013 Mar; 58(3):641-9. PMID: 23014846; PMCID: PMC3547156.
    35. Nabokina SM, Subramanian VS, Said HM. Effect of clinical mutations on functionality of the human riboflavin transporter-2 (hRFT-2). Mol Genet Metab. 2012 Apr; 105(4):652-7. PMID: 22273710; PMCID: PMC3309148.
    36. Subramanian VS, Subramanya SB, Said HM. Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells: studies utilizing Slc19a2 and Slc19a3 knockout mouse models. Am J Physiol Gastrointest Liver Physiol. 2012 Mar 01; 302(5):G572-8. PMID: 22194418; PMCID: PMC3311432.
    37. Vaziri ND, Yuan J, Rahimi A, Ni Z, Said H, Subramanian VS. Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation. Nephrol Dial Transplant. 2012 Jul; 27(7):2686-93. PMID: 22131233; PMCID: PMC3616758.
    38. Subramanya SB, Subramanian VS, Sekar VT, Said HM. Thiamin uptake by pancreatic acinar cells: effect of chronic alcohol feeding/exposure. Am J Physiol Gastrointest Liver Physiol. 2011 Nov; 301(5):G896-904. PMID: 21868632; PMCID: PMC3220324.
    39. Subramanian VS, Subramanya SB, Rapp L, Marchant JS, Ma TY, Said HM. Differential expression of human riboflavin transporters -1, -2, and -3 in polarized epithelia: a key role for hRFT-2 in intestinal riboflavin uptake. Biochim Biophys Acta. 2011 Dec; 1808(12):3016-21. PMID: 21854757; PMCID: PMC3196270.
    40. Ghosal A, Subramanian VS, Said HM. Role of the putative N-glycosylation and PKC-phosphorylation sites of the human sodium-dependent multivitamin transporter (hSMVT) in function and regulation. Biochim Biophys Acta. 2011 Aug; 1808(8):2073-80. PMID: 21570947; PMCID: PMC3130002.
    41. Subramanian VS, Rapp L, Marchant JS, Said HM. Role of cysteine residues in cell surface expression of the human riboflavin transporter-2 (hRFT2) in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011 Jul; 301(1):G100-9. PMID: 21512156; PMCID: PMC3129935.
    42. Subramanian VS, Subramanya SB, Said HM. Chronic alcohol exposure negatively impacts the physiological and molecular parameters of the renal biotin reabsorption process. Am J Physiol Renal Physiol. 2011 Mar; 300(3):F611-7. PMID: 21209005; PMCID: PMC3064131.
    43. Nabokina SM, Subramanian VS, Said HM. Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter. Am J Physiol Gastrointest Liver Physiol. 2011 Apr; 300(4):G561-7. PMID: 21183659; PMCID: PMC3074986.
    44. Subramanya SB, Subramanian VS, Kumar JS, Hoiness R, Said HM. Inhibition of intestinal biotin absorption by chronic alcohol feeding: cellular and molecular mechanisms. Am J Physiol Gastrointest Liver Physiol. 2011 Mar; 300(3):G494-501. PMID: 21148397; PMCID: PMC3064116.
    45. Subramanya SB, Subramanian VS, Said HM. Chronic alcohol consumption and intestinal thiamin absorption: effects on physiological and molecular parameters of the uptake process. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 299(1):G23-31. PMID: 20448146; PMCID: PMC2904112.
    46. Subramanian VS, Subramanya SB, Tsukamoto H, Said HM. Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F28-34. PMID: 20427470; PMCID: PMC2904160.
    47. Subramanian VS, Marchant JS, Said HM. Molecular determinants dictating cell surface expression of the human sodium-dependent vitamin C transporter-2 in human liver cells. Am J Physiol Gastrointest Liver Physiol. 2010 Feb; 298(2):G267-74. PMID: 19926816; PMCID: PMC2822508.
    48. Mee L, Nabokina SM, Sekar VT, Subramanian VS, Maedler K, Said HM. Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations. Am J Physiol Gastrointest Liver Physiol. 2009 Jul; 297(1):G197-206. PMID: 19423748; PMCID: PMC2711754.
    49. Subramanian VS, Marchant JS, Boulware MJ, Ma TY, Said HM. Membrane targeting and intracellular trafficking of the human sodium-dependent multivitamin transporter in polarized epithelial cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C663-71. PMID: 19211916; PMCID: PMC2670647.
    50. Reidling JC, Subramanian VS, Dahhan T, Sadat M, Said HM. Mechanisms and regulation of vitamin C uptake: studies of the hSVCT systems in human liver epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008 Dec; 295(6):G1217-27. PMID: 18845575; PMCID: PMC2604802.
    51. Subramanian VS, Reidling JC, Said HM. Differentiation-dependent regulation of the intestinal folate uptake process: studies with Caco-2 cells and native mouse intestine. Am J Physiol Cell Physiol. 2008 Sep; 295(3):C828-35. PMID: 18650265; PMCID: PMC2544450.
    52. Subramanian VS, Marchant JS, Reidling JC, Said HM. N-Glycosylation is required for Na+-dependent vitamin C transporter functionality. Biochem Biophys Res Commun. 2008 Sep 12; 374(1):123-7. PMID: 18619416; PMCID: PMC2528843.
    53. Said ZM, Subramanian VS, Vaziri ND, Said HM. Pyridoxine uptake by colonocytes: a specific and regulated carrier-mediated process. Am J Physiol Cell Physiol. 2008 May; 294(5):C1192-7. PMID: 18353902.
      View in: PubMed
    54. Subramanian VS, Marchant JS, Said HM. Apical membrane targeting and trafficking of the human proton-coupled transporter in polarized epithelia. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C233-40. PMID: 18003745.
      View in: PubMed
    55. Subramanian VS, Marchant JS, Ye D, Ma TY, Said HM. Tight junction targeting and intracellular trafficking of occludin in polarized epithelial cells. Am J Physiol Cell Physiol. 2007 Nov; 293(5):C1717-26. PMID: 17855770.
      View in: PubMed
    56. Subramanian VS, Marchant JS, Said HM. Targeting and intracellular trafficking of clinically relevant hTHTR1 mutations in human cell lines. Clin Sci (Lond). 2007 Jul; 113(2):93-102. PMID: 17331069.
      View in: PubMed
    57. Subramanian VS, Mohammed ZM, Molina A, Marchant JS, Vaziri ND, Said HM. Vitamin B1 (thiamine) uptake by human retinal pigment epithelial (ARPE-19) cells: mechanism and regulation. J Physiol. 2007 Jul 01; 582(Pt 1):73-85. PMID: 17463047; PMCID: PMC2075275.
    58. Subramanian VS, Marchant JS, Said HM. Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2. Am J Physiol Cell Physiol. 2006 Nov; 291(5):C851-9. PMID: 16790503.
      View in: PubMed
    59. Subramanian VS, Marchant JS, Said HM. Targeting and trafficking of the human thiamine transporter-2 in epithelial cells. J Biol Chem. 2006 Feb 24; 281(8):5233-45. PMID: 16371350.
      View in: PubMed
    60. Subramanian VS, Marchant JS, Boulware MJ, Said HM. A C-terminal region dictates the apical plasma membrane targeting of the human sodium-dependent vitamin C transporter-1 in polarized epithelia. J Biol Chem. 2004 Jun 25; 279(26):27719-28. PMID: 15084584.
      View in: PubMed
    61. Boulware MJ, Subramanian VS, Said HM, Marchant JS. Polarized expression of members of the solute carrier SLC19A gene family of water-soluble multivitamin transporters: implications for physiological function. Biochem J. 2003 Nov 15; 376(Pt 1):43-8. PMID: 14602044; PMCID: PMC1223768.
    62. Said HM, Balamurugan K, Subramanian VS, Marchant JS. Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine. Am J Physiol Gastrointest Liver Physiol. 2004 Mar; 286(3):G491-8. PMID: 14615284.
      View in: PubMed
    63. Subramanian VS, Chatterjee N, Said HM. Folate uptake in the human intestine: promoter activity and effect of folate deficiency. J Cell Physiol. 2003 Aug; 196(2):403-8. PMID: 12811835.
      View in: PubMed
    64. Nabokina SM, Subramanian VS, Said HM. Comparative analysis of ontogenic changes in renal and intestinal biotin transport in the rat. Am J Physiol Renal Physiol. 2003 Apr; 284(4):F737-42. PMID: 12620923.
      View in: PubMed
    65. Subramanian VS, Marchant JS, Parker I, Said HM. Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms. J Biol Chem. 2003 Feb 07; 278(6):3976-84. PMID: 12454006.
      View in: PubMed
    66. Marchant JS, Subramanian VS, Parker I, Said HM. Intracellular trafficking and membrane targeting mechanisms of the human reduced folate carrier in Mammalian epithelial cells. J Biol Chem. 2002 Sep 06; 277(36):33325-33. PMID: 12087110.
      View in: PubMed
    67. Reidling JC, Subramanian VS, Dudeja PK, Said HM. Expression and promoter analysis of SLC19A2 in the human intestine. Biochim Biophys Acta. 2002 Apr 12; 1561(2):180-7. PMID: 11997118.
      View in: PubMed
    68. Dey S, Subramanian VS, Chatterjee NS, Rubin SA, Said HM. Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT. Biochim Biophys Acta. 2002 Mar 19; 1574(2):187-92. PMID: 11955628.
      View in: PubMed
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