Gross, Steven P.

InstitutionUniversity of California, Irvine
DepartmentDevelopmental & Cell Biology
Address2222 Natural Sciences 1
Zot 2300
Irvine CA 92697
Phone(949) 824-3159, 3038
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    Collapse Research 
    Collapse Research Activities and Funding
    Single-molecule characterization of cytoplasmic dynein
    NIH/NIGMS R01GM070676Mar 1, 2005 - Mar 31, 2015
    Role: Principal Investigator
    In vivo regulation of bi-directional transport
    NIH/NIGMS R01GM064624Jul 1, 2002 - Jun 30, 2013
    Role: Principal Investigator
    NIH/NIGMS F32GM018329Jan 18, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Muretta JM, Reddy BJN, Scarabelli G, Thompson AF, Jariwala S, Major J, Venere M, Rich JN, Willard B, Thomas DD, Stumpff J, Grant BJ, Gross SP, Rosenfeld SS. A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):E1779-E1788. PMID: 29432173.
      View in: PubMed
    2. Bergman JP, Bovyn MJ, Doval FF, Sharma A, Gudheti MV, Gross SP, Allard JF, Vershinin MD. Cargo navigation across 3D microtubule intersections. Proc Natl Acad Sci U S A. 2018 Jan 16; 115(3):537-542. PMID: 29295928.
      View in: PubMed
    3. Reddy BJN, Tripathy S, Vershinin M, Tanenbaum ME, Xu J, Mattson-Hoss M, Arabi K, Chapman D, Doolin T, Hyeon C, Gross SP. Heterogeneity in kinesin function. Traffic. 2017 Oct; 18(10):658-671. PMID: 28731566.
      View in: PubMed
    4. Reddy BJ, Gross S. Dynein: Let's not get stuck! Cell Cycle. 2017 Jan 02; 16(1):7-8. PMID: 27657557.
      View in: PubMed
    5. Reddy BJ, Mattson M, Wynne CL, Vadpey O, Durra A, Chapman D, Vallee RB, Gross SP. Load-induced enhancement of Dynein force production by LIS1-NudE in vivo and in vitro. Nat Commun. 2016 Aug 04; 7:12259. PMID: 27489054; PMCID: PMC4976208.
    6. Muretta JM, Jun Y, Gross SP, Major J, Thomas DD, Rosenfeld SS. The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5. Proc Natl Acad Sci U S A. 2015 Dec 01; 112(48):E6606-13. PMID: 26627252; PMCID: PMC4672802.
    7. Shojania Feizabadi M, Janakaloti Narayanareddy BR, Vadpey O, Jun Y, Chapman D, Rosenfeld S, Gross SP. Microtubule C-Terminal Tails Can Change Characteristics of Motor Force Production. Traffic. 2015 Oct; 16(10):1075-87. PMID: 26094820.
      View in: PubMed
    8. Herms A, Bosch M, Reddy BJ, Schieber NL, Fajardo A, Rupérez C, Fernández-Vidal A, Ferguson C, Rentero C, Tebar F, Enrich C, Parton RG, Gross SP, Pol A. AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation. Nat Commun. 2015 May 27; 6:7176. PMID: 26013497; PMCID: PMC4446796.
    9. Tripathy SK, Weil SJ, Chen C, Anand P, Vallee RB, Gross SP. Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport. Nat Cell Biol. 2014 Dec; 16(12):1192-201. PMID: 25419851; PMCID: PMC4250405.
    10. Jun Y, Tripathy SK, Narayanareddy BR, Mattson-Hoss MK, Gross SP. Calibration of optical tweezers for in vivo force measurements: how do different approaches compare? Biophys J. 2014 Sep 16; 107(6):1474-84. PMID: 25229154; PMCID: PMC4167536.
    11. Narayanareddy BR, Vartiainen S, Hariri N, O'Dowd DK, Gross SP. A biophysical analysis of mitochondrial movement: differences between transport in neuronal cell bodies versus processes. Traffic. 2014 Jul; 15(7):762-71. PMID: 24673933; PMCID: PMC4065622.
    12. Mattson-Hoss MK, Niitani Y, Gordon EA, Jun Y, Bardwell L, Tomishige M, Gross SP. CK2 activates kinesin via induction of a conformational change. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):7000-5. PMID: 24782540; PMCID: PMC4024924.
    13. Pol A, Gross SP, Parton RG. Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites. J Cell Biol. 2014 Mar 03; 204(5):635-46. PMID: 24590170; PMCID: PMC3941045.
    14. Wortman JC, Shrestha UM, Barry DM, Garcia ML, Gross SP, Yu CC. Axonal transport: how high microtubule density can compensate for boundary effects in small-caliber axons. Biophys J. 2014 Feb 18; 106(4):813-23. PMID: 24559984; PMCID: PMC3944719.
    15. Goulet A, Major J, Jun Y, Gross SP, Rosenfeld SS, Moores CA. Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1837-42. PMID: 24449904; PMCID: PMC3918802.
    16. Kassan A, Herms A, Fernández-Vidal A, Bosch M, Schieber NL, Reddy BJ, Fajardo A, Gelabert-Baldrich M, Tebar F, Enrich C, Gross SP, Parton RG, Pol A. Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains. J Cell Biol. 2013 Dec 23; 203(6):985-1001. PMID: 24368806; PMCID: PMC3871434.
    17. Herms A, Bosch M, Ariotti N, Reddy BJ, Fajardo A, Fernández-Vidal A, Alvarez-Guaita A, Fernández-Rojo MA, Rentero C, Tebar F, Enrich C, Geli MI, Parton RG, Gross SP, Pol A. Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity. Curr Biol. 2013 Aug 05; 23(15):1489-96. PMID: 23871243; PMCID: PMC3746173.
    18. Bohannon KP, Jun Y, Gross SP, Smith GA. Differential protein partitioning within the herpesvirus tegument and envelope underlies a complex and variable virion architecture. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):E1613-20. PMID: 23569236; PMCID: PMC3637715.
    19. Erickson RP, Gross SP, Yu CC. Filament-filament switching can be regulated by separation between filaments together with cargo motor number. PLoS One. 2013; 8(2):e54298. PMID: 23457447; PMCID: PMC3573032.
    20. Gross SP. Come together: group behavior of dynein motors. Dev Cell. 2013 Jan 28; 24(2):117-8. PMID: 23369708.
      View in: PubMed
    21. Lee J, Gross SP, Lee J. Improved network community structure improves function prediction. Sci Rep. 2013; 3:2197. PMID: 23852097; PMCID: PMC3711050.
    22. Anand P, Cermelli S, Li Z, Kassan A, Bosch M, Sigua R, Huang L, Ouellette AJ, Pol A, Welte MA, Gross SP. A novel role for lipid droplets in the organismal antibacterial response. Elife. 2012 Nov 13; 1:e00003. PMID: 23150794; PMCID: PMC3491588.
    23. Xu J, Shu Z, King SJ, Gross SP. Tuning multiple motor travel via single motor velocity. Traffic. 2012 Sep; 13(9):1198-205. PMID: 22672518; PMCID: PMC3418377.
    24. Lee J, Gross SP, Lee J. Modularity optimization by conformational space annealing. Phys Rev E Stat Nonlin Soft Matter Phys. 2012 May; 85(5 Pt 2):056702. PMID: 23004898.
      View in: PubMed
    25. Sigua R, Tripathy S, Anand P, Gross SP. Isolation and purification of kinesin from Drosophila embryos. J Vis Exp. 2012 Apr 27; (62). PMID: 22565641; PMCID: PMC3466667.
    26. Xu J, Reddy BJ, Anand P, Shu Z, Cermelli S, Mattson MK, Tripathy SK, Hoss MT, James NS, King SJ, Huang L, Bardwell L, Gross SP. Casein kinase 2 reverses tail-independent inactivation of kinesin-1. Nat Commun. 2012 Mar 27; 3:754. PMID: 22453827; PMCID: PMC3574636.
    27. Kunwar A, Tripathy SK, Xu J, Mattson MK, Anand P, Sigua R, Vershinin M, McKenney RJ, Yu CC, Mogilner A, Gross SP. Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport. Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47):18960-5. PMID: 22084076; PMCID: PMC3223464.
    28. Yi JY, Ori-McKenney KM, McKenney RJ, Vershinin M, Gross SP, Vallee RB. High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport. J Cell Biol. 2011 Oct 17; 195(2):193-201. PMID: 22006948; PMCID: PMC3198168.
    29. Bosch M, Marí M, Gross SP, Fernández-Checa JC, Pol A. Mitochondrial cholesterol: a connection between caveolin, metabolism, and disease. Traffic. 2011 Nov; 12(11):1483-9. PMID: 21801290; PMCID: PMC3967746.
    30. Erickson RP, Jia Z, Gross SP, Yu CC. How molecular motors are arranged on a cargo is important for vesicular transport. PLoS Comput Biol. 2011 May; 7(5):e1002032. PMID: 21573204; PMCID: PMC3088656.
    31. Bosch M, Marí M, Herms A, Fernández A, Fajardo A, Kassan A, Giralt A, Colell A, Balgoma D, Barbero E, González-Moreno E, Matias N, Tebar F, Balsinde J, Camps M, Enrich C, Gross SP, García-Ruiz C, Pérez-Navarro E, Fernández-Checa JC, Pol A. Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr Biol. 2011 Apr 26; 21(8):681-6. PMID: 21497090; PMCID: PMC3409647.
    32. Ori-McKenney KM, Xu J, Gross SP, Vallee RB. A cytoplasmic dynein tail mutation impairs motor processivity. Nat Cell Biol. 2010 Dec; 12(12):1228-34. PMID: 21102439; PMCID: PMC3385513.
    33. McKenney RJ, Vershinin M, Kunwar A, Vallee RB, Gross SP. LIS1 and NudE induce a persistent dynein force-producing state. Cell. 2010 Apr 16; 141(2):304-14. PMID: 20403325; PMCID: PMC2881166.
    34. Bremner KH, Scherer J, Yi J, Vershinin M, Gross SP, Vallee RB. Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit. Cell Host Microbe. 2009 Dec 17; 6(6):523-35. PMID: 20006841; PMCID: PMC2810746.
    35. Ingelmo-Torres M, González-Moreno E, Kassan A, Hanzal-Bayer M, Tebar F, Herms A, Grewal T, Hancock JF, Enrich C, Bosch M, Gross SP, Parton RG, Pol A. Hydrophobic and basic domains target proteins to lipid droplets. Traffic. 2009 Dec; 10(12):1785-801. PMID: 19874557; PMCID: PMC2913680.
    36. Mallik R, Gross SP. Intracellular transport: how do motors work together? Curr Biol. 2009 May 26; 19(10):R416-8. PMID: 19467211.
      View in: PubMed
    37. Shubeita GT, Tran SL, Xu J, Vershinin M, Cermelli S, Cotton SL, Welte MA, Gross SP. Consequences of motor copy number on the intracellular transport of kinesin-1-driven lipid droplets. Cell. 2008 Dec 12; 135(6):1098-107. PMID: 19070579; PMCID: PMC2768369.
    38. Larsen KS, Xu J, Cermelli S, Shu Z, Gross SP. BicaudalD actively regulates microtubule motor activity in lipid droplet transport. PLoS One. 2008; 3(11):e3763. PMID: 19018277; PMCID: PMC2582182.
    39. Kunwar A, Vershinin M, Xu J, Gross SP. Stepping, strain gating, and an unexpected force-velocity curve for multiple-motor-based transport. Curr Biol. 2008 Aug 26; 18(16):1173-83. PMID: 18701289; PMCID: PMC3385514.
    40. Vershinin M, Xu J, Razafsky DS, King SJ, Gross SP. Tuning microtubule-based transport through filamentous MAPs: the problem of dynein. Traffic. 2008 Jun; 9(6):882-92. PMID: 18373727; PMCID: PMC2958055.
    41. Carter BC, Vershinin M, Gross SP. A comparison of step-detection methods: how well can you do? Biophys J. 2008 Jan 01; 94(1):306-19. PMID: 17827239; PMCID: PMC2134886.
    42. Gross SP, Vershinin M, Shubeita GT. Cargo transport: two motors are sometimes better than one. Curr Biol. 2007 Jun 19; 17(12):R478-86. PMID: 17580082.
      View in: PubMed
    43. Gross SP. Molecular motors: a tale of two filaments. Curr Biol. 2007 Apr 17; 17(8):R277-80. PMID: 17437703.
      View in: PubMed
    44. Petrov DY, Mallik R, Shubeita GT, Vershinin M, Gross SP, Yu CC. Studying molecular motor-based cargo transport: what is real and what is noise? Biophys J. 2007 Apr 15; 92(8):2953-63. PMID: 17277186; PMCID: PMC1831697.
    45. Vershinin M, Carter BC, Razafsky DS, King SJ, Gross SP. Multiple-motor based transport and its regulation by Tau. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):87-92. PMID: 17190808; PMCID: PMC1765483.
    46. Martinez JE, Vershinin MD, Shubeita GT, Gross SP. On the use of in vivo cargo velocity as a biophysical marker. Biochem Biophys Res Commun. 2007 Feb 16; 353(3):835-40. PMID: 17196170; PMCID: PMC2889695.
    47. Cermelli S, Guo Y, Gross SP, Welte MA. The lipid-droplet proteome reveals that droplets are a protein-storage depot. Curr Biol. 2006 Sep 19; 16(18):1783-95. PMID: 16979555.
      View in: PubMed
    48. Bullock SL, Nicol A, Gross SP, Zicha D. Guidance of bidirectional motor complexes by mRNA cargoes through control of dynein number and activity. Curr Biol. 2006 Jul 25; 16(14):1447-52. PMID: 16860745.
      View in: PubMed
    49. Antinone SE, Shubeita GT, Coller KE, Lee JI, Haverlock-Moyns S, Gross SP, Smith GA. The Herpesvirus capsid surface protein, VP26, and the majority of the tegument proteins are dispensable for capsid transport toward the nucleus. J Virol. 2006 Jun; 80(11):5494-8. PMID: 16699029; PMCID: PMC1472179.
    50. Singh MP, Mallik R, Gross SP, Yu CC. Monte Carlo modeling of single-molecule cytoplasmic dynein. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12059-64. PMID: 16103365; PMCID: PMC1189307.
    51. Welte MA, Cermelli S, Griner J, Viera A, Guo Y, Kim DH, Gindhart JG, Gross SP. Regulation of lipid-droplet transport by the perilipin homolog LSD2. Curr Biol. 2005 Jul 26; 15(14):1266-75. PMID: 16051169.
      View in: PubMed
    52. Lin F, Nguyen CM, Wang SJ, Saadi W, Gross SP, Jeon NL. Neutrophil migration in opposing chemoattractant gradients using microfluidic chemotaxis devices. Ann Biomed Eng. 2005 Apr; 33(4):475-82. PMID: 15909653.
      View in: PubMed
    53. Carter BC, Shubeita GT, Gross SP. Tracking single particles: a user-friendly quantitative evaluation. Phys Biol. 2005 Mar; 2(1):60-72. PMID: 16204858.
      View in: PubMed
    54. Mallik R, Gross SP. Molecular motors: strategies to get along. Curr Biol. 2004 Nov 23; 14(22):R971-82. PMID: 15556858.
      View in: PubMed
    55. Snider J, Lin F, Zahedi N, Rodionov V, Yu CC, Gross SP. Intracellular actin-based transport: how far you go depends on how often you switch. Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13204-9. PMID: 15331778; PMCID: PMC516548.
    56. Lin F, Nguyen CM, Wang SJ, Saadi W, Gross SP, Jeon NL. Effective neutrophil chemotaxis is strongly influenced by mean IL-8 concentration. Biochem Biophys Res Commun. 2004 Jun 25; 319(2):576-81. PMID: 15178445.
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    57. Gross SP. Hither and yon: a review of bi-directional microtubule-based transport. Phys Biol. 2004 Jun; 1(1-2):R1-11. PMID: 16204815.
      View in: PubMed
    58. Mallik R, Carter BC, Lex SA, King SJ, Gross SP. Cytoplasmic dynein functions as a gear in response to load. Nature. 2004 Feb 12; 427(6975):649-52. PMID: 14961123.
      View in: PubMed
    59. Rodionov V, Yi J, Kashina A, Oladipo A, Gross SP. Switching between microtubule- and actin-based transport systems in melanophores is controlled by cAMP levels. Curr Biol. 2003 Oct 28; 13(21):1837-47. PMID: 14588239.
      View in: PubMed
    60. Gross SP, Guo Y, Martinez JE, Welte MA. A determinant for directionality of organelle transport in Drosophila embryos. Curr Biol. 2003 Sep 30; 13(19):1660-8. PMID: 14521831.
      View in: PubMed
    61. Gross SP. Dynactin: coordinating motors with opposite inclinations. Curr Biol. 2003 Apr 15; 13(8):R320-2. PMID: 12699645.
      View in: PubMed
    62. Gross SP. Application of optical traps in vivo. Methods Enzymol. 2003; 361:162-74. PMID: 12624911.
      View in: PubMed
    63. Davis LJ, Odde DJ, Block SM, Gross SP. The importance of lattice defects in katanin-mediated microtubule severing in vitro. Biophys J. 2002 Jun; 82(6):2916-27. PMID: 12023214; PMCID: PMC1302079.
    64. Gross SP, Tuma MC, Deacon SW, Serpinskaya AS, Reilein AR, Gelfand VI. Interactions and regulation of molecular motors in Xenopus melanophores. J Cell Biol. 2002 Mar 04; 156(5):855-65. PMID: 11864991; PMCID: PMC2173315.
    65. Gross SP, Welte MA, Block SM, Wieschaus EF. Coordination of opposite-polarity microtubule motors. J Cell Biol. 2002 Feb 18; 156(4):715-24. PMID: 11854311; PMCID: PMC2174082.