Francesco Tombola

Title(s)Associate Professor, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-9137
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    Stretch-activated ion channels in human neural stem cell mechanotransduction
    NIH R21NS085628Feb 1, 2015 - Jan 31, 2018
    Role: Principal Investigator
    Mechanisms of Permeation and Gating of Voltage-Sensing Domains
    NIH R01GM098973Jul 1, 2011 - Nov 30, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD-ligand interactions. J Gen Physiol. 2021 09 06; 153(9). Zhao C, Hong L, Galpin JD, Riahi S, Lim VT, Webster PD, Tobias DJ, Ahern CA, Tombola F. PMID: 34228044; PMCID: PMC8263924.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    2. A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain. J Gen Physiol. 2021 09 06; 153(9). Zhao C, Hong L, Riahi S, Lim VT, Tobias DJ, Tombola F. PMID: 34228045; PMCID: PMC8263925.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    3. Voltage-gated proton channels from fungi highlight role of peripheral regions in channel activation. Commun Biol. 2021 02 26; 4(1):261. Zhao C, Tombola F. PMID: 33637875; PMCID: PMC7910559.
      View in: PubMed   Mentions: 4  Translation:AnimalsCells
    4. Thermodynamics and Mechanism of the Membrane Permeation of Hv1 Channel Blockers. J Membr Biol. 2021 02; 254(1):5-16. Lim VT, Freites JA, Tombola F, Tobias DJ. PMID: 33196887; PMCID: PMC8549822.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    5. Insights on small molecule binding to the Hv1 proton channel from free energy calculations with molecular dynamics simulations. Sci Rep. 2020 08 12; 10(1):13587. Lim VT, Geragotelis AD, Lim NM, Freites JA, Tombola F, Mobley DL, Tobias DJ. PMID: 32788614; PMCID: PMC7423955.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    6. Voltage-dependent structural models of the human Hv1 proton channel from long-timescale molecular dynamics simulations. Proc Natl Acad Sci U S A. 2020 06 16; 117(24):13490-13498. Geragotelis AD, Wood ML, Göddeke H, Hong L, Webster PD, Wong EK, Freites JA, Tombola F, Tobias DJ. PMID: 32461356; PMCID: PMC7306757.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    7. Growth and Spatial Control of Murine Neural Stem Cells on Reflectin Films. ACS Biomater Sci Eng. 2020 03 09; 6(3):1311-1320. Kautz R, Phan L, Arulmoli J, Chatterjee A, Kerr JP, Naeim M, Long J, Allevato A, Leal-Cruz JE, Le L, Derakhshan P, Tombola F, Flanagan LA, Gorodetsky AA. PMID: 33455403; PMCID: PMC7833438.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers. Commun Biol. 2019; 2:298. Ellefsen KL, Holt JR, Chang AC, Nourse JL, Arulmoli J, Mekhdjian AH, Abuwarda H, Tombola F, Flanagan LA, Dunn AR, Parker I, Pathak MM. PMID: 31396578; PMCID: PMC6685976.
      View in: PubMed   Mentions: 58  Translation:HumansAnimalsCells
    9. Atomistic Modeling of Ion Conduction through the Voltage-Sensing Domain of the Shaker K+ Ion Channel. J Phys Chem B. 2017 04 20; 121(15):3804-3812. Wood ML, Freites JA, Tombola F, Tobias DJ. PMID: 28074656; PMCID: PMC5605276.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    10. The Hv1 proton channel responds to mechanical stimuli. J Gen Physiol. 2016 11; 148(5):405-418. Pathak MM, Tran T, Hong L, Joós B, Morris CE, Tombola F. PMID: 27799320; PMCID: PMC5089936.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    11. Allostery: A lipid two-step. Nat Chem Biol. 2016 Apr; 12(4):202-3. Hong L, Tombola F. PMID: 26878551; PMCID: PMC5940328.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    12. Reflectin as a Material for Neural Stem Cell Growth. ACS Appl Mater Interfaces. 2016 Jan 13; 8(1):278-84. Phan L, Kautz R, Arulmoli J, Kim IH, Le DT, Shenk MA, Pathak MM, Flanagan LA, Tombola F, Gorodetsky AA. PMID: 26703760; PMCID: PMC4721522.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling. Sci Rep. 2015 Sep 14; 5:14077. Hong L, Singh V, Wulff H, Tombola F. PMID: 26365828; PMCID: PMC4568520.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    14. Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner. Sci Rep. 2015 Feb 17; 5:8499. Arulmoli J, Pathak MM, McDonnell LP, Nourse JL, Tombola F, Earthman JC, Flanagan LA. PMID: 25686615; PMCID: PMC4330529.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    15. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16148-53. Pathak MM, Nourse JL, Tran T, Hwe J, Arulmoli J, Le DT, Bernardis E, Flanagan LA, Tombola F. PMID: 25349416; PMCID: PMC4234578.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansCellsCTClinical Trials
    16. Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1. PLoS One. 2014; 9(8):e105926. Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT, Zlotnik A, Soltesz I, Tombola F. PMID: 25165868; PMCID: PMC4148356.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9971-6. Hong L, Kim IH, Tombola F. PMID: 24912149; PMCID: PMC4103315.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    18. Membrane biophysics define neuron and astrocyte progenitors in the neural lineage. Stem Cells. 2014 Mar; 32(3):706-16. Nourse JL, Prieto JL, Dickson AR, Lu J, Pathak MM, Tombola F, Demetriou M, Lee AP, Flanagan LA. PMID: 24105912; PMCID: PMC5367858.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    19. Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains. Neuron. 2013 Jan 23; 77(2):274-87. Hong L, Pathak MM, Kim IH, Ta D, Tombola F. PMID: 23352164; PMCID: PMC3559007.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    20. Water wires in atomistic models of the Hv1 proton channel. Biochim Biophys Acta. 2012 Feb; 1818(2):286-93. Wood ML, Schow EV, Freites JA, White SH, Tombola F, Tobias DJ. PMID: 21843503; PMCID: PMC3245885.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    21. The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity. Nat Struct Mol Biol. 2010 Jan; 17(1):44-50. Tombola F, Ulbrich MH, Kohout SC, Isacoff EY. PMID: 20023640; PMCID: PMC2925041.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    22. Architecture and gating of Hv1 proton channels. J Physiol. 2009 Nov 15; 587(Pt 22):5325-9. Tombola F, Ulbrich MH, Isacoff EY. PMID: 19915215; PMCID: PMC2793866.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    23. The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron. 2008 May 22; 58(4):546-56. Tombola F, Ulbrich MH, Isacoff EY. PMID: 18498736; PMCID: PMC2430592.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    24. Closing in on the resting state of the Shaker K(+) channel. Neuron. 2007 Oct 04; 56(1):124-40. Pathak MM, Yarov-Yarovoy V, Agarwal G, Roux B, Barth P, Kohout S, Tombola F, Isacoff EY. PMID: 17920020.
      View in: PubMed   Mentions: 187     Fields:    Translation:AnimalsCells
    25. Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model. World J Gastroenterol. 2007 Jan 21; 13(3):349-54. Ruggiero P, Rossi G, Tombola F, Pancotto L, Lauretti L, Del Giudice G, Zoratti M. PMID: 17230601; PMCID: PMC4065887.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    26. The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature. 2007 Feb 01; 445(7127):546-9. Tombola F, Pathak MM, Gorostiza P, Isacoff EY. PMID: 17187057.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    27. Polyphenols reduce gastritis induced by Helicobacter pylori infection or VacA toxin administration in mice. Antimicrob Agents Chemother. 2006 Jul; 50(7):2550-2. Ruggiero P, Tombola F, Rossi G, Pancotto L, Lauretti L, Del Giudice G, Zoratti M. PMID: 16801443; PMCID: PMC1489755.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    28. How does voltage open an ion channel? Annu Rev Cell Dev Biol. 2006; 22:23-52. Tombola F, Pathak MM, Isacoff EY. PMID: 16704338.
      View in: PubMed   Mentions: 150     Fields:    Translation:AnimalsCells
    29. How far will you go to sense voltage? Neuron. 2005 Dec 08; 48(5):719-25. Tombola F, Pathak MM, Isacoff EY. PMID: 16337910.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    30. Molecular handles for the mechanical manipulation of single-membrane proteins in living cells. IEEE Trans Nanobioscience. 2005 Dec; 4(4):269-76. Gorostiza P, Tombola F, Verdaguer A, Smith SB, Bustamante C, Isacoff EY. PMID: 16433292; PMCID: PMC1414782.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    31. The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax. FEBS Lett. 2005 Jul 04; 579(17):3695-700. Campello S, De Marchi U, Szabò I, Tombola F, Martinou JC, Zoratti M. PMID: 15963994.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    32. Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron. 2005 Feb 03; 45(3):379-88. Tombola F, Pathak MM, Isacoff EY. PMID: 15694325.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    33. The cooperative voltage sensor motion that gates a potassium channel. J Gen Physiol. 2005 Jan; 125(1):57-69. Pathak M, Kurtz L, Tombola F, Isacoff E. PMID: 15623895; PMCID: PMC1414780.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    34. Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondria. J Biol Chem. 2004 Sep 03; 279(36):37415-22. De Marchi U, Campello S, Szabò I, Tombola F, Martinou JC, Zoratti M. PMID: 15229226.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    35. Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. FEBS Lett. 2003 May 22; 543(1-3):184-9. Tombola F, Campello S, De Luca L, Ruggiero P, Del Giudice G, Papini E, Zoratti M. PMID: 12753930.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    36. The Vibrio cholerae haemolysin anion channel is required for cell vacuolation and death. Cell Microbiol. 2002 Jul; 4(7):397-409. Moschioni M, Tombola F, de Bernard M, Coelho A, Zitzer A, Zoratti M, Montecucco C. PMID: 12102686.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    37. DNA interacts with Bacillus subtilis mechano-sensitive channels in native membrane patches. Cell Physiol Biochem. 2002; 12(2-3):127-34. Szabo I, Tombola F, Martinucci S, Zoratti M. PMID: 12077558.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    38. How the loop and middle regions influence the properties of Helicobacter pylori VacA channels. Biophys J. 2001 Dec; 81(6):3204-15. Tombola F, Pagliaccia C, Campello S, Telford JL, Montecucco C, Papini E, Zoratti M. PMID: 11720986; PMCID: PMC1301780.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    39. Vacuolation induced by VacA toxin of Helicobacter pylori requires the intracellular accumulation of membrane permeant bases, Cl(-) and water. FEBS Lett. 2001 Nov 23; 508(3):479-83. Morbiato L, Tombola F, Campello S, Del Giudice G, Rappuoli R, Zoratti M, Papini E. PMID: 11728476.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    40. The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia. J Clin Invest. 2001 Sep; 108(6):929-37. Tombola F, Morbiato L, Del Giudice G, Rappuoli R, Zoratti M, Papini E. PMID: 11560962; PMCID: PMC200932.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    41. Ca2+-reversible inhibition of the mitochondrial megachannel by ubiquinone analogues. FEBS Lett. 2000 Sep 01; 480(2-3):89-94. Martinucci S, Szabò I, Tombola F, Zoratti M. PMID: 11034306.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    42. Blockers of VacA provide insights into the structure of the pore. Biophys J. 2000 Aug; 79(2):863-73. Tombola F, Del Giudice G, Papini E, Zoratti M. PMID: 10920018; PMCID: PMC1300984.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    43. Extramitochondrial porin: facts and hypotheses. J Bioenerg Biomembr. 2000 Feb; 32(1):79-89. Báthori G, Parolini I, Szabó I, Tombola F, Messina A, Oliva M, Sargiacomo M, De Pinto V, Zoratti M. PMID: 11768765.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    44. Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori. FEBS Lett. 1999 Oct 29; 460(2):221-5. Tombola F, Oregna F, Brutsche S, Szabò I, Del Giudice G, Rappuoli R, Montecucco C, Papini E, Zoratti M. PMID: 10544239.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    45. Porin is present in the plasma membrane where it is concentrated in caveolae and caveolae-related domains. J Biol Chem. 1999 Oct 15; 274(42):29607-12. Bàthori G, Parolini I, Tombola F, Szabò I, Messina A, Oliva M, De Pinto V, Lisanti M, Sargiacomo M, Zoratti M. PMID: 10514428.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    46. Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity. EMBO J. 1999 Oct 15; 18(20):5517-27. Szabò I, Brutsche S, Tombola F, Moschioni M, Satin B, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M. PMID: 10523296; PMCID: PMC1171620.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    47. Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation. Biophys J. 1999 Mar; 76(3):1401-9. Tombola F, Carlesso C, Szabò I, de Bernard M, Reyrat JM, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M. PMID: 10049322; PMCID: PMC1300118.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    48. Double-stranded DNA can be translocated across a planar membrane containing purified mitochondrial porin. FASEB J. 1998 Apr; 12(6):495-502. Szabò I, Bàthori G, Tombola F, Coppola A, Schmehl I, Brini M, Ghazi A, De Pinto V, Zoratti M. PMID: 9535222.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    49. Novel aspects of the electrophysiology of mitochondrial porin. Biochem Biophys Res Commun. 1998 Feb 04; 243(1):258-63. Báthori G, Szabó I, Schmehl I, Tombola F, Messina A, De Pinto V, Zoratti M. PMID: 9473514.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    50. DNA translocation across planar bilayers containing Bacillus subtilis ion channels. J Biol Chem. 1997 Oct 03; 272(40):25275-82. Szabò I, Bàthori G, Tombola F, Brini M, Coppola A, Zoratti M. PMID: 9312144.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
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