Francesco Tombola

Title(s)Professor, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-9137
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    Stretch-activated ion channels in human neural stem cell mechanotransduction
    NIH R21NS085628Feb 1, 2015 - Jan 31, 2018
    Role: Principal Investigator
    Mechanisms of Permeation and Gating of Voltage-Sensing Domains
    NIH R01GM098973Jul 1, 2011 - Nov 30, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An essential role for the Hv1 voltage-gated proton channel in Pseudomonas aeruginosa corneal infection. bioRxiv. 2024 Jul 16. Rodriguez P, Abbondante S, Marshall M, Abdelmeseh J, Tombola F, Pearlman E. PMID: 39071375; PMCID: PMC11275807.
      View in: PubMed   Mentions:
    2. Mechanically-primed voltage-gated proton channels from angiosperm plants. Nat Commun. 2023 11 18; 14(1):7515. Zhao C, Webster PD, De Angeli A, Tombola F. PMID: 37980353; PMCID: PMC10657467.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Nanowire biosensors with olfactory proteins: towards a genuine electronic nose with single molecule sensitivity and high selectivity. Nanotechnology. 2023 Aug 29; 34(46). Noh S, Tombola F, Burke P. PMID: 37524056.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD-ligand interactions. J Gen Physiol. 2021 09 06; 153(9). Zhao C, Hong L, Galpin JD, Riahi S, Lim VT, Webster PD, Tobias DJ, Ahern CA, Tombola F. PMID: 34228044; PMCID: PMC8263924.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    5. A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain. J Gen Physiol. 2021 09 06; 153(9). Zhao C, Hong L, Riahi S, Lim VT, Tobias DJ, Tombola F. PMID: 34228045; PMCID: PMC8263925.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    6. Voltage-gated proton channels from fungi highlight role of peripheral regions in channel activation. Commun Biol. 2021 02 26; 4(1):261. Zhao C, Tombola F. PMID: 33637875; PMCID: PMC7910559.
      View in: PubMed   Mentions: 12  Translation:AnimalsCells
    7. Thermodynamics and Mechanism of the Membrane Permeation of Hv1 Channel Blockers. J Membr Biol. 2021 02; 254(1):5-16. Lim VT, Freites JA, Tombola F, Tobias DJ. PMID: 33196887; PMCID: PMC8549822.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    8. Insights on small molecule binding to the Hv1 proton channel from free energy calculations with molecular dynamics simulations. Sci Rep. 2020 08 12; 10(1):13587. Lim VT, Geragotelis AD, Lim NM, Freites JA, Tombola F, Mobley DL, Tobias DJ. PMID: 32788614; PMCID: PMC7423955.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. Voltage-dependent structural models of the human Hv1 proton channel from long-timescale molecular dynamics simulations. Proc Natl Acad Sci U S A. 2020 06 16; 117(24):13490-13498. Geragotelis AD, Wood ML, Göddeke H, Hong L, Webster PD, Wong EK, Freites JA, Tombola F, Tobias DJ. PMID: 32461356; PMCID: PMC7306757.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    10. Growth and Spatial Control of Murine Neural Stem Cells on Reflectin Films. ACS Biomater Sci Eng. 2020 03 09; 6(3):1311-1320. Kautz R, Phan L, Arulmoli J, Chatterjee A, Kerr JP, Naeim M, Long J, Allevato A, Leal-Cruz JE, Le L, Derakhshan P, Tombola F, Flanagan LA, Gorodetsky AA. PMID: 33455403; PMCID: PMC7833438.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers. Commun Biol. 2019; 2:298. Ellefsen KL, Holt JR, Chang AC, Nourse JL, Arulmoli J, Mekhdjian AH, Abuwarda H, Tombola F, Flanagan LA, Dunn AR, Parker I, Pathak MM. PMID: 31396578; PMCID: PMC6685976.
      View in: PubMed   Mentions: 95  Translation:HumansAnimalsCells
    12. Atomistic Modeling of Ion Conduction through the Voltage-Sensing Domain of the Shaker K+ Ion Channel. J Phys Chem B. 2017 04 20; 121(15):3804-3812. Wood ML, Freites JA, Tombola F, Tobias DJ. PMID: 28074656; PMCID: PMC5605276.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    13. The Hv1 proton channel responds to mechanical stimuli. J Gen Physiol. 2016 11; 148(5):405-418. Pathak MM, Tran T, Hong L, Joós B, Morris CE, Tombola F. PMID: 27799320; PMCID: PMC5089936.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    14. Allostery: A lipid two-step. Nat Chem Biol. 2016 Apr; 12(4):202-3. Hong L, Tombola F. PMID: 26878551; PMCID: PMC5940328.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    15. Reflectin as a Material for Neural Stem Cell Growth. ACS Appl Mater Interfaces. 2016 Jan 13; 8(1):278-84. Phan L, Kautz R, Arulmoli J, Kim IH, Le DT, Shenk MA, Pathak MM, Flanagan LA, Tombola F, Gorodetsky AA. PMID: 26703760; PMCID: PMC4721522.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    16. Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling. Sci Rep. 2015 Sep 14; 5:14077. Hong L, Singh V, Wulff H, Tombola F. PMID: 26365828; PMCID: PMC4568520.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    17. Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner. Sci Rep. 2015 Feb 17; 5:8499. Arulmoli J, Pathak MM, McDonnell LP, Nourse JL, Tombola F, Earthman JC, Flanagan LA. PMID: 25686615; PMCID: PMC4330529.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    18. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16148-53. Pathak MM, Nourse JL, Tran T, Hwe J, Arulmoli J, Le DT, Bernardis E, Flanagan LA, Tombola F. PMID: 25349416; PMCID: PMC4234578.
      View in: PubMed   Mentions: 277     Fields:    Translation:HumansCellsCTClinical Trials
    19. Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1. PLoS One. 2014; 9(8):e105926. Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT, Zlotnik A, Soltesz I, Tombola F. PMID: 25165868; PMCID: PMC4148356.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    20. Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9971-6. Hong L, Kim IH, Tombola F. PMID: 24912149; PMCID: PMC4103315.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    21. Membrane biophysics define neuron and astrocyte progenitors in the neural lineage. Stem Cells. 2014 Mar; 32(3):706-16. Nourse JL, Prieto JL, Dickson AR, Lu J, Pathak MM, Tombola F, Demetriou M, Lee AP, Flanagan LA. PMID: 24105912; PMCID: PMC5367858.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    22. Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains. Neuron. 2013 Jan 23; 77(2):274-87. Hong L, Pathak MM, Kim IH, Ta D, Tombola F. PMID: 23352164; PMCID: PMC3559007.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    23. Water wires in atomistic models of the Hv1 proton channel. Biochim Biophys Acta. 2012 Feb; 1818(2):286-93. Wood ML, Schow EV, Freites JA, White SH, Tombola F, Tobias DJ. PMID: 21843503; PMCID: PMC3245885.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    24. The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity. Nat Struct Mol Biol. 2010 Jan; 17(1):44-50. Tombola F, Ulbrich MH, Kohout SC, Isacoff EY. PMID: 20023640; PMCID: PMC2925041.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    25. Architecture and gating of Hv1 proton channels. J Physiol. 2009 Nov 15; 587(Pt 22):5325-9. Tombola F, Ulbrich MH, Isacoff EY. PMID: 19915215; PMCID: PMC2793866.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    26. The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron. 2008 May 22; 58(4):546-56. Tombola F, Ulbrich MH, Isacoff EY. PMID: 18498736; PMCID: PMC2430592.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    27. Closing in on the resting state of the Shaker K(+) channel. Neuron. 2007 Oct 04; 56(1):124-40. Pathak MM, Yarov-Yarovoy V, Agarwal G, Roux B, Barth P, Kohout S, Tombola F, Isacoff EY. PMID: 17920020.
      View in: PubMed   Mentions: 189     Fields:    Translation:AnimalsCells
    28. Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model. World J Gastroenterol. 2007 Jan 21; 13(3):349-54. Ruggiero P, Rossi G, Tombola F, Pancotto L, Lauretti L, Del Giudice G, Zoratti M. PMID: 17230601; PMCID: PMC4065887.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    29. The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature. 2007 Feb 01; 445(7127):546-9. Tombola F, Pathak MM, Gorostiza P, Isacoff EY. PMID: 17187057.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    30. Polyphenols reduce gastritis induced by Helicobacter pylori infection or VacA toxin administration in mice. Antimicrob Agents Chemother. 2006 Jul; 50(7):2550-2. Ruggiero P, Tombola F, Rossi G, Pancotto L, Lauretti L, Del Giudice G, Zoratti M. PMID: 16801443; PMCID: PMC1489755.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    31. How does voltage open an ion channel? Annu Rev Cell Dev Biol. 2006; 22:23-52. Tombola F, Pathak MM, Isacoff EY. PMID: 16704338.
      View in: PubMed   Mentions: 154     Fields:    Translation:AnimalsCells
    32. How far will you go to sense voltage? Neuron. 2005 Dec 08; 48(5):719-25. Tombola F, Pathak MM, Isacoff EY. PMID: 16337910.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    33. Molecular handles for the mechanical manipulation of single-membrane proteins in living cells. IEEE Trans Nanobioscience. 2005 Dec; 4(4):269-76. Gorostiza P, Tombola F, Verdaguer A, Smith SB, Bustamante C, Isacoff EY. PMID: 16433292; PMCID: PMC1414782.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax. FEBS Lett. 2005 Jul 04; 579(17):3695-700. Campello S, De Marchi U, Szabò I, Tombola F, Martinou JC, Zoratti M. PMID: 15963994.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    35. Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron. 2005 Feb 03; 45(3):379-88. Tombola F, Pathak MM, Isacoff EY. PMID: 15694325.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    36. The cooperative voltage sensor motion that gates a potassium channel. J Gen Physiol. 2005 Jan; 125(1):57-69. Pathak M, Kurtz L, Tombola F, Isacoff E. PMID: 15623895; PMCID: PMC1414780.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    37. Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondria. J Biol Chem. 2004 Sep 03; 279(36):37415-22. De Marchi U, Campello S, Szabò I, Tombola F, Martinou JC, Zoratti M. PMID: 15229226.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    38. Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. FEBS Lett. 2003 May 22; 543(1-3):184-9. Tombola F, Campello S, De Luca L, Ruggiero P, Del Giudice G, Papini E, Zoratti M. PMID: 12753930.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    39. The vacuolating toxin of Helicobacter pylori mimicks the CFTR-mediated chloride conductance. FEBS Lett. 2002 Dec 04; 532(1-2):237-40. Campello S, Tombola F, Cabrini G, Zoratti M. PMID: 12459497.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    40. The Vibrio cholerae haemolysin anion channel is required for cell vacuolation and death. Cell Microbiol. 2002 Jul; 4(7):397-409. Moschioni M, Tombola F, de Bernard M, Coelho A, Zitzer A, Zoratti M, Montecucco C. PMID: 12102686.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    41. DNA interacts with Bacillus subtilis mechano-sensitive channels in native membrane patches. Cell Physiol Biochem. 2002; 12(2-3):127-34. Szabo I, Tombola F, Martinucci S, Zoratti M. PMID: 12077558.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    42. How the loop and middle regions influence the properties of Helicobacter pylori VacA channels. Biophys J. 2001 Dec; 81(6):3204-15. Tombola F, Pagliaccia C, Campello S, Telford JL, Montecucco C, Papini E, Zoratti M. PMID: 11720986; PMCID: PMC1301780.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    43. Vacuolation induced by VacA toxin of Helicobacter pylori requires the intracellular accumulation of membrane permeant bases, Cl(-) and water. FEBS Lett. 2001 Nov 23; 508(3):479-83. Morbiato L, Tombola F, Campello S, Del Giudice G, Rappuoli R, Zoratti M, Papini E. PMID: 11728476.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    44. The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia. J Clin Invest. 2001 Sep; 108(6):929-37. Tombola F, Morbiato L, Del Giudice G, Rappuoli R, Zoratti M, Papini E. PMID: 11560962; PMCID: PMC200932.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    45. Ca2+-reversible inhibition of the mitochondrial megachannel by ubiquinone analogues. FEBS Lett. 2000 Sep 01; 480(2-3):89-94. Martinucci S, Szabò I, Tombola F, Zoratti M. PMID: 11034306.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    46. Blockers of VacA provide insights into the structure of the pore. Biophys J. 2000 Aug; 79(2):863-73. Tombola F, Del Giudice G, Papini E, Zoratti M. PMID: 10920018; PMCID: PMC1300984.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    47. Extramitochondrial porin: facts and hypotheses. J Bioenerg Biomembr. 2000 Feb; 32(1):79-89. Báthori G, Parolini I, Szabó I, Tombola F, Messina A, Oliva M, Sargiacomo M, De Pinto V, Zoratti M. PMID: 11768765.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    48. Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori. FEBS Lett. 1999 Oct 29; 460(2):221-5. Tombola F, Oregna F, Brutsche S, Szabò I, Del Giudice G, Rappuoli R, Montecucco C, Papini E, Zoratti M. PMID: 10544239.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    49. Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity. EMBO J. 1999 Oct 15; 18(20):5517-27. Szabò I, Brutsche S, Tombola F, Moschioni M, Satin B, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M. PMID: 10523296; PMCID: PMC1171620.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    50. Porin is present in the plasma membrane where it is concentrated in caveolae and caveolae-related domains. J Biol Chem. 1999 Oct 15; 274(42):29607-12. Bàthori G, Parolini I, Tombola F, Szabò I, Messina A, Oliva M, De Pinto V, Lisanti M, Sargiacomo M, Zoratti M. PMID: 10514428.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    51. Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation. Biophys J. 1999 Mar; 76(3):1401-9. Tombola F, Carlesso C, Szabò I, de Bernard M, Reyrat JM, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M. PMID: 10049322; PMCID: PMC1300118.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    52. Double-stranded DNA can be translocated across a planar membrane containing purified mitochondrial porin. FASEB J. 1998 Apr; 12(6):495-502. Szabò I, Bàthori G, Tombola F, Coppola A, Schmehl I, Brini M, Ghazi A, De Pinto V, Zoratti M. PMID: 9535222.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    53. Novel aspects of the electrophysiology of mitochondrial porin. Biochem Biophys Res Commun. 1998 Feb 04; 243(1):258-63. Báthori G, Szabó I, Schmehl I, Tombola F, Messina A, De Pinto V, Zoratti M. PMID: 9473514.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    54. DNA translocation across planar bilayers containing Bacillus subtilis ion channels. J Biol Chem. 1997 Oct 03; 272(40):25275-82. Szabò I, Bàthori G, Tombola F, Brini M, Coppola A, Zoratti M. PMID: 9312144.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
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