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Tombola, Francesco

TitleAssociate Professor
InstitutionUniversity of California, Irvine
DepartmentPhysiology and Biophysics
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-9137
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    Collapse Research 
    Collapse Research Activities and Funding
    Stretch-activated ion channels in human neural stem cell mechanotransduction
    NIH/NINDS R21NS085628Feb 1, 2015 - Jan 31, 2017
    Role: Principal Investigator
    Mechanisms of Permeation and Gating of Voltage-Sensing Domains
    NIH/NIGMS R01GM098973Jul 1, 2011 - Nov 30, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wood ML, Freites JA, Tombola F, Tobias DJ. Atomistic Modeling of Ion Conduction through the Voltage-Sensing Domain of the Shaker K+ Ion Channel. J Phys Chem B. 2017 04 20; 121(15):3804-3812. PMID: 28074656.
      View in: PubMed
    2. Pathak MM, Tran T, Hong L, Joós B, Morris CE, Tombola F. The Hv1 proton channel responds to mechanical stimuli. J Gen Physiol. 2016 11; 148(5):405-418. PMID: 27799320.
      View in: PubMed
    3. Hong L, Tombola F. Allostery: A lipid two-step. Nat Chem Biol. 2016 Apr; 12(4):202-3. PMID: 26878551.
      View in: PubMed
    4. Phan L, Kautz R, Arulmoli J, Kim IH, Le DT, Shenk MA, Pathak MM, Flanagan LA, Tombola F, Gorodetsky AA. Reflectin as a Material for Neural Stem Cell Growth. ACS Appl Mater Interfaces. 2016 Jan 13; 8(1):278-84. PMID: 26703760; PMCID: PMC4721522 [Available on 12/24/16].
    5. Hong L, Singh V, Wulff H, Tombola F. Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling. Sci Rep. 2015 Sep 14; 5:14077. PMID: 26365828; PMCID: PMC4568520.
    6. Arulmoli J, Pathak MM, McDonnell LP, Nourse JL, Tombola F, Earthman JC, Flanagan LA. Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner. Sci Rep. 2015 Feb 17; 5:8499. PMID: 25686615; PMCID: PMC4330529.
    7. Pathak MM, Nourse JL, Tran T, Hwe J, Arulmoli J, Le DT, Bernardis E, Flanagan LA, Tombola F. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16148-53. PMID: 25349416; PMCID: PMC4234578.
    8. Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT, Zlotnik A, Soltesz I, Tombola F. Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1. PLoS One. 2014; 9(8):e105926. PMID: 25165868; PMCID: PMC4148356.
    9. Hong L, Kim IH, Tombola F. Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9971-6. PMID: 24912149; PMCID: PMC4103315.
    10. Nourse JL, Prieto JL, Dickson AR, Lu J, Pathak MM, Tombola F, Demetriou M, Lee AP, Flanagan LA. Membrane biophysics define neuron and astrocyte progenitors in the neural lineage. Stem Cells. 2014 Mar; 32(3):706-16. PMID: 24105912.
      View in: PubMed
    11. Hong L, Pathak MM, Kim IH, Ta D, Tombola F. Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains. Neuron. 2013 Jan 23; 77(2):274-87. PMID: 23352164; PMCID: PMC3559007.
    12. Wood ML, Schow EV, Freites JA, White SH, Tombola F, Tobias DJ. Water wires in atomistic models of the Hv1 proton channel. Biochim Biophys Acta. 2012 Feb; 1818(2):286-93. PMID: 21843503; PMCID: PMC3245885.
    13. Tombola F, Ulbrich MH, Kohout SC, Isacoff EY. The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity. Nat Struct Mol Biol. 2010 Jan; 17(1):44-50. PMID: 20023640; PMCID: PMC2925041.
    14. Tombola F, Ulbrich MH, Isacoff EY. Architecture and gating of Hv1 proton channels. J Physiol. 2009 Nov 15; 587(Pt 22):5325-9. PMID: 19915215; PMCID: PMC2793866.
    15. Tombola F, Ulbrich MH, Isacoff EY. The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron. 2008 May 22; 58(4):546-56. PMID: 18498736; PMCID: PMC2430592.
    16. Pathak MM, Yarov-Yarovoy V, Agarwal G, Roux B, Barth P, Kohout S, Tombola F, Isacoff EY. Closing in on the resting state of the Shaker K(+) channel. Neuron. 2007 Oct 04; 56(1):124-40. PMID: 17920020.
      View in: PubMed
    17. Ruggiero P, Rossi G, Tombola F, Pancotto L, Lauretti L, Del Giudice G, Zoratti M. Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model. World J Gastroenterol. 2007 Jan 21; 13(3):349-54. PMID: 17230601; PMCID: PMC4065887.
    18. Tombola F, Pathak MM, Gorostiza P, Isacoff EY. The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature. 2007 Feb 01; 445(7127):546-9. PMID: 17187057.
      View in: PubMed
    19. Ruggiero P, Tombola F, Rossi G, Pancotto L, Lauretti L, Del Giudice G, Zoratti M. Polyphenols reduce gastritis induced by Helicobacter pylori infection or VacA toxin administration in mice. Antimicrob Agents Chemother. 2006 Jul; 50(7):2550-2. PMID: 16801443; PMCID: PMC1489755.
    20. Tombola F, Pathak MM, Isacoff EY. How does voltage open an ion channel? Annu Rev Cell Dev Biol. 2006; 22:23-52. PMID: 16704338.
      View in: PubMed
    21. Tombola F, Pathak MM, Isacoff EY. How far will you go to sense voltage? Neuron. 2005 Dec 08; 48(5):719-25. PMID: 16337910.
      View in: PubMed
    22. Gorostiza P, Tombola F, Verdaguer A, Smith SB, Bustamante C, Isacoff EY. Molecular handles for the mechanical manipulation of single-membrane proteins in living cells. IEEE Trans Nanobioscience. 2005 Dec; 4(4):269-76. PMID: 16433292; PMCID: PMC1414782.
    23. Campello S, De Marchi U, Szabò I, Tombola F, Martinou JC, Zoratti M. The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax. FEBS Lett. 2005 Jul 04; 579(17):3695-700. PMID: 15963994.
      View in: PubMed
    24. Tombola F, Pathak MM, Isacoff EY. Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron. 2005 Feb 03; 45(3):379-88. PMID: 15694325.
      View in: PubMed
    25. Pathak M, Kurtz L, Tombola F, Isacoff E. The cooperative voltage sensor motion that gates a potassium channel. J Gen Physiol. 2005 Jan; 125(1):57-69. PMID: 15623895; PMCID: PMC1414780.
    26. De Marchi U, Campello S, Szabò I, Tombola F, Martinou JC, Zoratti M. Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondria. J Biol Chem. 2004 Sep 03; 279(36):37415-22. PMID: 15229226.
      View in: PubMed
    27. Tombola F, Campello S, De Luca L, Ruggiero P, Del Giudice G, Papini E, Zoratti M. Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. FEBS Lett. 2003 May 22; 543(1-3):184-9. PMID: 12753930.
      View in: PubMed
    28. Campello S, Tombola F, Cabrini G, Zoratti M. The vacuolating toxin of Helicobacter pylori mimicks the CFTR-mediated chloride conductance. FEBS Lett. 2002 Dec 04; 532(1-2):237-40. PMID: 12459497.
      View in: PubMed
    29. Moschioni M, Tombola F, de Bernard M, Coelho A, Zitzer A, Zoratti M, Montecucco C. The Vibrio cholerae haemolysin anion channel is required for cell vacuolation and death. Cell Microbiol. 2002 Jul; 4(7):397-409. PMID: 12102686.
      View in: PubMed
    30. Szabo I, Tombola F, Martinucci S, Zoratti M. DNA interacts with Bacillus subtilis mechano-sensitive channels in native membrane patches. Cell Physiol Biochem. 2002; 12(2-3):127-34. PMID: 12077558.
      View in: PubMed
    31. Tombola F, Pagliaccia C, Campello S, Telford JL, Montecucco C, Papini E, Zoratti M. How the loop and middle regions influence the properties of Helicobacter pylori VacA channels. Biophys J. 2001 Dec; 81(6):3204-15. PMID: 11720986; PMCID: PMC1301780.
    32. Morbiato L, Tombola F, Campello S, Del Giudice G, Rappuoli R, Zoratti M, Papini E. Vacuolation induced by VacA toxin of Helicobacter pylori requires the intracellular accumulation of membrane permeant bases, Cl(-) and water. FEBS Lett. 2001 Nov 23; 508(3):479-83. PMID: 11728476.
      View in: PubMed
    33. Tombola F, Morbiato L, Del Giudice G, Rappuoli R, Zoratti M, Papini E. The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia. J Clin Invest. 2001 Sep; 108(6):929-37. PMID: 11560962; PMCID: PMC200932.
    34. Martinucci S, Szabò I, Tombola F, Zoratti M. Ca2+-reversible inhibition of the mitochondrial megachannel by ubiquinone analogues. FEBS Lett. 2000 Sep 01; 480(2-3):89-94. PMID: 11034306.
      View in: PubMed
    35. Tombola F, Del Giudice G, Papini E, Zoratti M. Blockers of VacA provide insights into the structure of the pore. Biophys J. 2000 Aug; 79(2):863-73. PMID: 10920018; PMCID: PMC1300984.
    36. Báthori G, Parolini I, Szabó I, Tombola F, Messina A, Oliva M, Sargiacomo M, De Pinto V, Zoratti M. Extramitochondrial porin: facts and hypotheses. J Bioenerg Biomembr. 2000 Feb; 32(1):79-89. PMID: 11768765.
      View in: PubMed
    37. Tombola F, Oregna F, Brutsche S, Szabò I, Del Giudice G, Rappuoli R, Montecucco C, Papini E, Zoratti M. Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori. FEBS Lett. 1999 Oct 29; 460(2):221-5. PMID: 10544239.
      View in: PubMed
    38. Bàthori G, Parolini I, Tombola F, Szabò I, Messina A, Oliva M, De Pinto V, Lisanti M, Sargiacomo M, Zoratti M. Porin is present in the plasma membrane where it is concentrated in caveolae and caveolae-related domains. J Biol Chem. 1999 Oct 15; 274(42):29607-12. PMID: 10514428.
      View in: PubMed
    39. Szabò I, Brutsche S, Tombola F, Moschioni M, Satin B, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M. Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity. EMBO J. 1999 Oct 15; 18(20):5517-27. PMID: 10523296; PMCID: PMC1171620.
    40. Tombola F, Carlesso C, Szabò I, de Bernard M, Reyrat JM, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M. Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation. Biophys J. 1999 Mar; 76(3):1401-9. PMID: 10049322; PMCID: PMC1300118.
    41. Szabò I, Bàthori G, Tombola F, Coppola A, Schmehl I, Brini M, Ghazi A, De Pinto V, Zoratti M. Double-stranded DNA can be translocated across a planar membrane containing purified mitochondrial porin. FASEB J. 1998 Apr; 12(6):495-502. PMID: 9535222.
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    42. Báthori G, Szabó I, Schmehl I, Tombola F, Messina A, De Pinto V, Zoratti M. Novel aspects of the electrophysiology of mitochondrial porin. Biochem Biophys Res Commun. 1998 Feb 04; 243(1):258-63. PMID: 9473514.
      View in: PubMed
    43. Szabò I, Bàthori G, Tombola F, Brini M, Coppola A, Zoratti M. DNA translocation across planar bilayers containing Bacillus subtilis ion channels. J Biol Chem. 1997 Oct 03; 272(40):25275-82. PMID: 9312144.
      View in: PubMed