Timothy Scott Kern

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-5324
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Neutrophil elastase and Gasdermin D in diabetic retinopathy
    NIH R01EY033002Sep 30, 2021 - Aug 31, 2026
    Role: Principal Investigator
    BLR&D Research Career Scientist Application
    NIH IK6BX003604Oct 1, 2016 - Sep 30, 2021
    Role: Principal Investigator
    Novel therapies to inhibit Diabetic Retinopathy
    NIH R24EY024864Apr 1, 2015 - Mar 31, 2021
    Role: Principal Investigator
    Acetylation and diabetic retinopathy
    NIH I01BX002117Apr 1, 2014 - Mar 31, 2018
    Role: Principal Investigator
    Role of Photoreceptors in the Pathogenesis of Diabetic Retinopathy
    NIH R01EY022938Sep 1, 2013 - May 31, 2022
    Role: Principal Investigator
    Global Characterization of Lysine Acetylation in Diabetic Retina
    NIH R21EY021595Jan 1, 2012 - Dec 31, 2013
    Role: Co-Principal Investigator
    PATHOGENESIS OF DIABETIC MICROVASCULAR COMPLICATIONS
    NIH P01DK057733Sep 1, 2000 - Aug 31, 2005
    Role: Principal Investigator
    Study of diabetic retinopathy
    NIH R01EY000300Dec 1, 1977 - Feb 28, 2015
    Role: Principal Investigator
    Study of diabetic retinopathy
    NIH R56EY000300Dec 1, 1977 - Sep 29, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice. Diabetologia. 2023 Mar; 66(3):590-602. Saadane A, Veenstra AA, Minns MS, Tang J, Du Y, Abubakr Elghazali F, Lessieur EM, Pearlman E, Kern TS. PMID: 36698021; PMCID: PMC9892100.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes. Diabetologia. 2022 10; 65(10):1734-1744. Lessieur EM, Liu H, Saadane A, Du Y, Kiser J, Kern TS. PMID: 35852587; PMCID: PMC9481679.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an a1-antitrypsin-derived peptide motif. Nat Nanotechnol. 2022 09; 17(9):1004-1014. Cruz MA, Bohinc D, Andraska EA, Alvikas J, Raghunathan S, Masters NA, van Kleef ND, Bane KL, Hart K, Medrow K, Sun M, Liu H, Haldeman S, Banerjee A, Lessieur EM, Hageman K, Gandhi A, de la Fuente M, Nieman MT, Kern TS, Maas C, de Maat S, Neeves KB, Neal MD, Sen Gupta A, Stavrou EX. PMID: 35851383.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2021 10 04; 62(13):7. Lessieur EM, Liu H, Saadane A, Du Y, Tang J, Kiser J, Kern TS. PMID: 34643662; PMCID: PMC8525836.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies. Mol Pharmacol. 2021 11; 100(5):470-479. Kern TS, Du Y, Tang J, Lee CA, Liu H, Dreffs A, Leinonen H, Antonetti DA, Palczewski K. PMID: 34393108; PMCID: PMC9175131.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Negative regulation of FOXP3 expression by c-Rel O-GlcNAcylation. Glycobiology. 2021 08 07; 31(7):812-826. de Jesus TJ, Tomalka JA, Centore JT, Staback Rodriguez FD, Agarwal RA, Liu AR, Kern TS, Ramakrishnan P. PMID: 33442719; PMCID: PMC8351495.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy. Am J Pathol. 2021 10; 191(10):1805-1821. Saadane A, Du Y, Thoreson WB, Miyagi M, Lessieur EM, Kiser J, Wen X, Berkowitz BA, Kern TS. PMID: 34214506; PMCID: PMC8579242.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Sildenafil-evoked photoreceptor oxidative stress in vivo is unrelated to impaired visual performance in mice. PLoS One. 2021; 16(3):e0245161. Berkowitz BA, Podolsky RH, Lins Childers K, Saadane A, Kern TS, Roberts R, Olds H, Joy J, Richards C, Rosales T, Schneider M, Schilling B, Orchanian A, Graffice E, Sinan K, Qian H, Harp L. PMID: 33661941; PMCID: PMC7932139.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    9. A cell-penetrating CD40-TRAF2,3 blocking peptide diminishes inflammation and neuronal loss after ischemia/reperfusion. FASEB J. 2021 03; 35(3):e21412. Portillo JC, Yu JS, Hansen S, Kern TS, Subauste MC, Subauste CS. PMID: 33675257; PMCID: PMC8101361.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. Fatty acid oxidation and photoreceptor metabolic needs. J Lipid Res. 2021; 62:100035. Fu Z, Kern TS, Hellstr?m A, Smith LEH. PMID: 32094231; PMCID: PMC7905050.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    11. Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model. J Control Release. 2021 02 10; 330:329-340. Sun D, Sun W, Gao SQ, Wei C, Naderi A, Schilb AL, Scheidt J, Lee S, Kern TS, Palczewski K, Lu ZR. PMID: 33358976; PMCID: PMC9066847.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. Prog Retin Eye Res. 2021 07; 83:100919. Tonade D, Kern TS. PMID: 33188897; PMCID: PMC8113320.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    13. Successful induction of diabetes in mice demonstrates no gender difference in development of early diabetic retinopathy. PLoS One. 2020; 15(9):e0238727. Saadane A, Lessieur EM, Du Y, Liu H, Kern TS. PMID: 32941450; PMCID: PMC7498040.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    14. All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion. Invest Ophthalmol Vis Sci. 2020 06 03; 61(6):8. Dreffs A, Lin CM, Liu X, Shanmugam S, Abcouwer SF, Kern TS, Antonetti DA. PMID: 32492112; PMCID: PMC7415894.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium. ACS Appl Bio Mater. 2020 May 18; 3(5):3078-3086. Sun D, Schur RM, Sears AE, Gao SQ, Sun W, Naderi A, Kern T, Palczewski K, Lu ZR. PMID: 34327311; PMCID: PMC8317636.
      View in: PubMed   Mentions: 3     Fields:    
    16. Neutrophil elastase contributes to the pathological vascular permeability characteristic of diabetic retinopathy. Diabetologia. 2019 12; 62(12):2365-2374. Liu H, Lessieur EM, Saadane A, Lindstrom SI, Taylor PR, Kern TS. PMID: 31612267; PMCID: PMC6866660.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    17. Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles. Mol Ther. 2020 01 08; 28(1):293-303. Sun D, Schur RM, Sears AE, Gao SQ, Vaidya A, Sun W, Maeda A, Kern T, Palczewski K, Lu ZR. PMID: 31611143; PMCID: PMC6952167.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    18. Dyslipidemia in retinal metabolic disorders. EMBO Mol Med. 2019 10; 11(10):e10473. Fu Z, Chen CT, Cagnone G, Heckel E, Sun Y, Cakir B, Tomita Y, Huang S, Li Q, Britton W, Cho SS, Kern TS, Hellstr?m A, Joyal JS, Smith LE. PMID: 31486227; PMCID: PMC6783651.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    19. Pathophysiology of Diabetic Retinopathy: Contribution and Limitations of Laboratory Research. Ophthalmic Res. 2019; 62(4):196-202. Kern TS, Antonetti DA, Smith LEH. PMID: 31362288; PMCID: PMC6872907.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    20. Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy. Sci Transl Med. 2019 07 03; 11(499). Yokomizo H, Maeda Y, Park K, Clermont AC, Hernandez SL, Fickweiler W, Li Q, Wang CH, Paniagua SM, Simao F, Ishikado A, Sun B, Wu IH, Katagiri S, Pober DM, Tinsley LJ, Avery RL, Feener EP, Kern TS, Keenan HA, Aiello LP, Sun JK, King GL. PMID: 31270273; PMCID: PMC7132633.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    21. Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration. J Diabetes Complications. 2019 09; 33(9):668-674. Lindstrom SI, Sigurdardottir S, Zapadka TE, Tang J, Liu H, Taylor BE, Smith DG, Lee CA, DeAngelis J, Kern TS, Taylor PR. PMID: 31239234; PMCID: PMC6690768.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    22. Diabetes-mediated IL-17A enhances retinal inflammation, oxidative stress, and vascular permeability. Cell Immunol. 2019 07; 341:103921. Sigurdardottir S, Zapadka TE, Lindstrom SI, Liu H, Taylor BE, Lee CA, Kern TS, Taylor PR. PMID: 31076079; PMCID: PMC6599623.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    23. Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2019 04 01; 60(5):1538-1546. Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS. PMID: 30994864; PMCID: PMC6736377.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    24. Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study. Diabetologia. 2019 06; 62(6):1024-1035. Bryrup T, Thomsen CW, Kern T, Allin KH, Brandslund I, J?rgensen NR, Vestergaard H, Hansen T, Hansen TH, Pedersen O, Nielsen T. PMID: 30904939; PMCID: PMC6509092.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCTClinical Trials
    25. Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. Methods Mol Biol. 2019; 1834:333-343. Palczewska G, Kern TS, Palczewski K. PMID: 30324453; PMCID: PMC6991118.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    26. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. JCI Insight. 2018 09 06; 3(17). Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. PMID: 30185665; PMCID: PMC6171813.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    27. D-cis-Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo. Invest Ophthalmol Vis Sci. 2018 06 01; 59(7):2999-3010. Berkowitz BA, Podolsky RH, Farrell B, Lee H, Trepanier C, Berri AM, Dernay K, Graffice E, Shafie-Khorassani F, Kern TS, Roberts R. PMID: 30025125; PMCID: PMC5995482.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    28. The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice. Invest Ophthalmol Vis Sci. 2018 04 01; 59(5):2042-2053. Nahomi RB, Sampathkumar S, Myers AM, Elghazi L, Smith DG, Tang J, Lee CA, Kern TS, Nagaraj RH, Fort PE. PMID: 29677366; PMCID: PMC5908388.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    29. Targeting CD6 for the treatment of experimental autoimmune uveitis. J Autoimmun. 2018 06; 90:84-93. Zhang L, Li Y, Qiu W, Bell BA, Dvorina N, Baldwin WM, Singer N, Kern T, Caspi RR, Fox DA, Lin F. PMID: 29472120; PMCID: PMC5949263.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    30. Photobiomodulation Inhibits Long-term Structural and Functional Lesions of Diabetic Retinopathy. Diabetes. 2018 02; 67(2):291-298. Cheng Y, Du Y, Liu H, Tang J, Veenstra A, Kern TS. PMID: 29167189; PMCID: PMC5780063.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    31. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 02; 364(2):207-220. Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. PMID: 29162627; PMCID: PMC5771314.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    32. Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. 2017 10; 60(10):2111-2120. Tonade D, Liu H, Palczewski K, Kern TS. PMID: 28755268; PMCID: PMC5660634.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    33. Diabetes of 5 years duration does not lead to photoreceptor degeneration in the canine non-tapetal inferior-nasal retina. Exp Eye Res. 2017 09; 162:126-128. Tonade D, Kern TS. PMID: 28734672; PMCID: PMC5788031.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. Do photoreceptor cells cause the development of retinal vascular disease? Vision Res. 2017 10; 139:65-71. Kern TS. PMID: 28438678; PMCID: PMC5677572.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    35. Loss of CD40 attenuates experimental diabetes-induced retinal inflammation but does not protect mice from electroretinogram defects. Vis Neurosci. 2017 01; 34:E009. Samuels IS, Portillo JC, Miao Y, Kern TS, Subauste CS. PMID: 28965505; PMCID: PMC8893597.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    36. Mechanistic Insights into Pathological Changes in the Diabetic Retina: Implications for Targeting Diabetic Retinopathy. Am J Pathol. 2017 Jan; 187(1):9-19. Roy S, Kern TS, Song B, Stuebe C. PMID: 27846381; PMCID: PMC5225303.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    37. Ligation of CD40 in Human M�ller Cells Induces P2X7 Receptor-Dependent Death of Retinal Endothelial Cells. Invest Ophthalmol Vis Sci. 2016 11 01; 57(14):6278-6286. Portillo JC, Lopez Corcino Y, Dubyak GR, Kern TS, Matsuyama S, Subauste CS. PMID: 27893093; PMCID: PMC5119488.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    38. Eyes on systems pharmacology. Pharmacol Res. 2016 Dec; 114:39-41. Chen Y, Kern TS, Kiser PD, Palczewski K. PMID: 27720767; PMCID: PMC5154905.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    39. Lymphoblastoid Cell Lines as a Tool to Study Inter-Individual Differences in the Response to Glucose. PLoS One. 2016; 11(8):e0160504. Grassi MA, Rao VR, Chen S, Cao D, Gao X, Cleary PA, Huang RS, Paterson AD, Natarajan R, Rehman J, Kern TS, DCCT/EDIC Research Group. PMID: 27509144; PMCID: PMC4979894.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    40. Photoreceptor Cells Produce Inflammatory Mediators That Contribute to Endothelial Cell Death in Diabetes. Invest Ophthalmol Vis Sci. 2016 08 01; 57(10):4264-71. Tonade D, Liu H, Kern TS. PMID: 27548900; PMCID: PMC5015981.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    41. Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Invest Ophthalmol Vis Sci. 2016 08 01; 57(10):4272-81. Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS. PMID: 27548901; PMCID: PMC5015983.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    42. CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy. Diabetes. 2017 02; 66(2):483-493. Portillo JC, Lopez Corcino Y, Miao Y, Tang J, Sheibani N, Kern TS, Dubyak GR, Subauste CS. PMID: 27474370; PMCID: PMC5248988.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    43. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci Signal. 2016 07 26; 9(438):ra74. Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. PMID: 27460988; PMCID: PMC4972460.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    44. Image registration and averaging of low laser power two-photon fluorescence images of mouse retina. Biomed Opt Express. 2016 Jul 01; 7(7):2671-91. Alexander NS, Palczewska G, Stremplewski P, Wojtkowski M, Kern TS, Palczewski K. PMID: 27446697; PMCID: PMC4948621.
      View in: PubMed   Mentions: 12  
    45. Systemic Retinaldehyde Treatment Corrects Retinal Oxidative Stress, Rod Dysfunction, and Impaired Visual Performance in Diabetic Mice. Invest Ophthalmol Vis Sci. 2015 Oct; 56(11):6294-303. Berkowitz BA, Kern TS, Bissig D, Patel P, Bhatia A, Kefalov VJ, Roberts R. PMID: 26431483; PMCID: PMC4594469.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    46. Photobiomodulation Mitigates Diabetes-Induced Retinopathy by Direct and Indirect Mechanisms: Evidence from Intervention Studies in Pigmented Mice. PLoS One. 2015; 10(10):e0139003. Saliba A, Du Y, Liu H, Patel S, Roberts R, Berkowitz BA, Kern TS. PMID: 26426815; PMCID: PMC4591336.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    47. Diabetic Retinopathy: Retina-Specific Methods for Maintenance of Diabetic Rodents and Evaluation of Vascular Histopathology and Molecular Abnormalities. Curr Protoc Mouse Biol. 2015 Sep 01; 5(3):247-270. Veenstra A, Liu H, Lee CA, Du Y, Tang J, Kern TS. PMID: 26331759; PMCID: PMC4597317.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    48. Retinylamine Benefits Early Diabetic Retinopathy in Mice. J Biol Chem. 2015 Aug 28; 290(35):21568-79. Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, von Lintig J, Palczewski K, Kern TS. PMID: 26139608; PMCID: PMC4571881.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    49. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May; 29(5):2194-204. Du Y, Cramer M, Lee CA, Tang J, Muthusamy A, Antonetti DA, Jin H, Palczewski K, Kern TS. PMID: 25667222; PMCID: PMC4415023.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    50. Metanx and early stages of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2015 Jan 08; 56(1):647-53. Liu H, Tang J, Lee CA, Kern TS. PMID: 25574044; PMCID: PMC4311777.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    51. Photoreceptors in diabetic retinopathy. J Diabetes Investig. 2015 Jul; 6(4):371-80. Kern TS, Berkowitz BA. PMID: 26221514; PMCID: PMC4511295.
      View in: PubMed   Mentions: 63     Fields:    
    52. Proinflammatory responses induced by CD40 in retinal endothelial and M�ller cells are inhibited by blocking CD40-Traf2,3 or CD40-Traf6 signaling. Invest Ophthalmol Vis Sci. 2014 Dec 04; 55(12):8590-7. Portillo JA, Schwartz I, Zarini S, Bapputty R, Kern TS, Gubitosi-Klug RA, Murphy RC, Subauste MC, Subauste CS. PMID: 25477319; PMCID: PMC4280881.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    53. CD40 promotes the development of early diabetic retinopathy in mice. Diabetologia. 2014 Oct; 57(10):2222-31. Portillo JA, Greene JA, Okenka G, Miao Y, Sheibani N, Kern TS, Subauste CS. PMID: 25015056; PMCID: PMC4291184.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    54. Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol. Am J Pathol. 2014 Sep; 184(9):2403-19. Saadane A, Mast N, Charvet CD, Omarova S, Zheng W, Huang SS, Kern TS, Peachey NS, Pikuleva IA. PMID: 25065682; PMCID: PMC4188134.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    55. Interrelationships between the Retinal Neuroglia and Vasculature in Diabetes. Diabetes Metab J. 2014 Jun; 38(3):163-70. Kern TS. PMID: 25003068; PMCID: PMC4083021.
      View in: PubMed   Mentions: 21  
    56. Diabetes-induced impairment in visual function in mice: contributions of p38 MAPK, rage, leukocytes, and aldose reductase. Invest Ophthalmol Vis Sci. 2014 May 02; 55(5):2904-10. Lee CA, Li G, Patel MD, Petrash JM, Benetz BA, Veenstra A, Amengual J, von Lintig J, Burant CJ, Tang J, Kern TS. PMID: 23920367; PMCID: PMC4010365.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    57. Photobiomodulation in the treatment of patients with non-center-involving diabetic macular oedema. Br J Ophthalmol. 2014 Aug; 98(8):1013-5. Tang J, Herda AA, Kern TS. PMID: 24682183; PMCID: PMC4106479.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    58. Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy. PLoS One. 2014; 9(1):e84671. Rajashekhar G, Ramadan A, Abburi C, Callaghan B, Traktuev DO, Evans-Molina C, Maturi R, Harris A, Kern TS, March KL. PMID: 24416262; PMCID: PMC3886987.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    59. Modulation of retinal Müller cells by complement receptor C5aR. Invest Ophthalmol Vis Sci. 2013 Dec 17; 54(13):8191-8. Cheng L, Bu H, Portillo JA, Li Y, Subauste CS, Huang SS, Kern TS, Lin F. PMID: 24265019; PMCID: PMC3867184.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    60. NRF2 plays a protective role in diabetic retinopathy in mice. Diabetologia. 2014 Jan; 57(1):204-13. Xu Z, Wei Y, Gong J, Cho H, Park JK, Sung ER, Huang H, Wu L, Eberhart C, Handa JT, Du Y, Kern TS, Thimmulappa R, Barber AJ, Biswal S, Duh EJ. PMID: 24186494; PMCID: PMC4039644.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    61. Antagonism of CD11b with neutrophil inhibitory factor (NIF) inhibits vascular lesions in diabetic retinopathy. PLoS One. 2013; 8(10):e78405. Veenstra AA, Tang J, Kern TS. PMID: 24205223; PMCID: PMC3804483.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    62. Leukocytes from diabetic patients kill retinal endothelial cells: effects of berberine. Mol Vis. 2013; 19:2092-105. Tian P, Ge H, Liu H, Kern TS, Du L, Guan L, Su S, Liu P. PMID: 24146542; PMCID: PMC3800284.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    63. Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16586-91. Du Y, Veenstra A, Palczewski K, Kern TS. PMID: 24067647; PMCID: PMC3799310.
      View in: PubMed   Mentions: 177     Fields:    Translation:AnimalsCells
    64. IGFBP-3 and TNF-a regulate retinal endothelial cell apoptosis. Invest Ophthalmol Vis Sci. 2013 Aug 09; 54(8):5376-84. Zhang Q, Jiang Y, Miller MJ, Peng B, Liu L, Soderland C, Tang J, Kern TS, Pintar J, Steinle JJ. PMID: 23868984; PMCID: PMC3741024.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    65. �2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype. PLoS One. 2013; 8(7):e70555. Jiang Y, Zhang Q, Liu L, Tang J, Kern TS, Steinle JJ. PMID: 23894672; PMCID: PMC3722144.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    66. MyD88-dependent pathways in leukocytes affect the retina in diabetes. PLoS One. 2013; 8(7):e68871. Tang J, Allen Lee C, Du Y, Sun Y, Pearlman E, Sheibani N, Kern TS. PMID: 23874797; PMCID: PMC3708907.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    67. Degeneration of retinal ganglion cells in diabetic dogs and mice: relationship to glycemic control and retinal capillary degeneration. Mol Vis. 2013; 19:1413-21. Howell SJ, Mekhail MN, Azem R, Ward NL, Kern TS. PMID: 23825921; PMCID: PMC3695756.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    68. Low-intensity far-red light inhibits early lesions that contribute to diabetic retinopathy: in vivo and in vitro. Invest Ophthalmol Vis Sci. 2013 May 01; 54(5):3681-90. Tang J, Du Y, Lee CA, Talahalli R, Eells JT, Kern TS. PMID: 23557732; PMCID: PMC3668802.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    69. Circulating mononuclear progenitor cells: differential roles for subpopulations in repair of retinal vascular injury. Invest Ophthalmol Vis Sci. 2013 Apr 26; 54(4):3000-9. Caballero S, Hazra S, Bhatwadekar A, Li Calzi S, Paradiso LJ, Miller LP, Chang LJ, Kern TS, Grant MB. PMID: 23572102; PMCID: PMC3638665.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    70. Deletion of aldose reductase from mice inhibits diabetes-induced retinal capillary degeneration and superoxide generation. PLoS One. 2013; 8(4):e62081. Tang J, Du Y, Petrash JM, Sheibani N, Kern TS. PMID: 23614016; PMCID: PMC3628579.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    71. Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model. Diabetologia. 2013 Mar; 56(3):644-53. Hazra S, Jarajapu YP, Stepps V, Caballero S, Thinschmidt JS, Sautina L, Bengtsson N, Licalzi S, Dominguez J, Kern TS, Segal MS, Ash JD, Saban DR, Bartelmez SH, Grant MB. PMID: 23192694; PMCID: PMC3773610.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    72. Exclusion of aldose reductase as a mediator of ERG deficits in a mouse model of diabetic eye disease. Vis Neurosci. 2012 Nov; 29(6):267-74. Samuels IS, Lee CA, Petrash JM, Peachey NS, Kern TS. PMID: 23101909; PMCID: PMC3745719.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    73. Leukocytes regulate retinal capillary degeneration in the diabetic mouse via generation of leukotrienes. J Leukoc Biol. 2013 Jan; 93(1):135-43. Talahalli R, Zarini S, Tang J, Li G, Murphy R, Kern TS, Gubitosi-Klug RA. PMID: 23108096; PMCID: PMC3525833.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    74. Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice. Diabetes. 2012 Dec; 61(12):3294-303. Li G, Veenstra AA, Talahalli RR, Wang X, Gubitosi-Klug RA, Sheibani N, Kern TS. PMID: 22923475; PMCID: PMC3501859.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    75. Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy. Invest Ophthalmol Vis Sci. 2012 Aug 13; 53(9):5520-6. Li Y, Smith D, Li Q, Sheibani N, Huang S, Kern T, Nagaraj RH, Lin F. PMID: 22786897; PMCID: PMC3419006.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    76. Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice. Nutr Diabetes. 2012 Jul 23; 2:e36. Sapieha P, Chen J, Stahl A, Seaward MR, Favazza TL, Juan AM, Hatton CJ, Joyal JS, Krah NM, Dennison RJ, Tang J, Kern TS, Akula JD, Smith LE. PMID: 23448719; PMCID: PMC3408641.
      View in: PubMed   Mentions: 29     Fields:    
    77. Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals. Dis Model Mech. 2012 Jul; 5(4):444-56. Robinson R, Barathi VA, Chaurasia SS, Wong TY, Kern TS. PMID: 22730475; PMCID: PMC3380708.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimals
    78. Acetylation of retinal histones in diabetes increases inflammatory proteins: effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC). J Biol Chem. 2012 Jul 27; 287(31):25869-80. Kadiyala CS, Zheng L, Du Y, Yohannes E, Kao HY, Miyagi M, Kern TS. PMID: 22648458; PMCID: PMC3406672.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    79. Inhibition of poly(ADP-ribose) polymerase inhibits ischemia/reperfusion induced neurodegeneration in retina via suppression of endoplasmic reticulum stress. Biochem Biophys Res Commun. 2012 Jun 29; 423(2):276-81. Li C, Wang L, Kern TS, Zheng L. PMID: 22640737.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    80. Compound 49b prevents diabetes-induced apoptosis through increased IGFBP-3 levels. Invest Ophthalmol Vis Sci. 2012 May 17; 53(6):3004-13. Zhang Q, Guy K, Pagadala J, Jiang Y, Walker RJ, Liu L, Soderland C, Kern TS, Ferry R, He H, Yates CR, Miller DD, Steinle JJ. PMID: 22467575; PMCID: PMC3378083.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    81. Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen species production in kidney cortical tubules in early diabetes. Diabetes. 2012 Aug; 61(8):2074-83. Rosca MG, Vazquez EJ, Chen Q, Kerner J, Kern TS, Hoppel CL. PMID: 22586586; PMCID: PMC3402323.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    82. Transcriptome analysis using next generation sequencing reveals molecular signatures of diabetic retinopathy and efficacy of candidate drugs. Mol Vis. 2012; 18:1123-46. Kandpal RP, Rajasimha HK, Brooks MJ, Nellissery J, Wan J, Qian J, Kern TS, Swaroop A. PMID: 22605924; PMCID: PMC3351417.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    83. Evidence for diffuse central retinal edema in vivo in diabetic male Sprague Dawley rats. PLoS One. 2012; 7(1):e29619. Berkowitz BA, Bissig D, Ye Y, Valsadia P, Kern TS, Roberts R. PMID: 22253747; PMCID: PMC3256169.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    84. Beneficial effects of a novel RAGE inhibitor on early diabetic retinopathy and tactile allodynia. Mol Vis. 2011; 17:3156-65. Li G, Tang J, Du Y, Lee CA, Kern TS. PMID: 22171162; PMCID: PMC3235538.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    85. Retinal pericytes inhibit activated T cell proliferation. Invest Ophthalmol Vis Sci. 2011 Nov 21; 52(12):9005-10. Tu Z, Li Y, Smith DS, Sheibani N, Huang S, Kern T, Lin F. PMID: 22003106; PMCID: PMC3231798.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    86. Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury. PLoS One. 2011; 6(8):e23194. Wang L, Li C, Guo H, Kern TS, Huang K, Zheng L. PMID: 21858029; PMCID: PMC3153496.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    87. The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. Diabetes. 2011 Sep; 60(9):2370-8. Opreanu M, Tikhonenko M, Bozack S, Lydic TA, Reid GE, McSorley KM, Sochacki A, Perez GI, Esselman WJ, Kern T, Kolesnick R, Grant MB, Busik JV. PMID: 21771974; PMCID: PMC3161322.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    88. Increased tumor necrosis factor-a, cleaved caspase 3 levels and insulin receptor substrate-1 phosphorylation in the �1-adrenergic receptor knockout mouse. Mol Vis. 2011; 17:1822-8. Panjala SR, Jiang Y, Kern TS, Thomas SA, Steinle JJ. PMID: 21850156; PMCID: PMC3137556.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    89. Inflammation in diabetic retinopathy. Prog Retin Eye Res. 2011 Sep; 30(5):343-58. Tang J, Kern TS. PMID: 21635964; PMCID: PMC3433044.
      View in: PubMed   Mentions: 482     Fields:    Translation:HumansAnimalsCells
    90. NF-κB subunits are differentially distributed in cells of lumbar dorsal root ganglia in naïve and diabetic rats. Neurosci Lett. 2011 Feb 18; 490(1):41-5. Berti-Mattera LN, Larkin B, Hourmouzis Z, Kern TS, Siegel RE. PMID: 21167912; PMCID: PMC4079108.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    91. Validation of structural and functional lesions of diabetic retinopathy in mice. Mol Vis. 2010 Oct 19; 16:2121-31. Kern TS, Tang J, Berkowitz BA. PMID: 21139688; PMCID: PMC2994360.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    92. PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine. Am J Physiol Regul Integr Comp Physiol. 2010 Dec; 299(6):R1610-7. Du Y, Kowluru A, Kern TS. PMID: 20881100; PMCID: PMC3774204.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    93. Comparison of three strains of diabetic rats with respect to the rate at which retinopathy and tactile allodynia develop. Mol Vis. 2010 Aug 15; 16:1629-39. Kern TS, Miller CM, Tang J, Du Y, Ball SL, Berti-Matera L. PMID: 20806092; PMCID: PMC2927372.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    94. Application of isoproterenol inhibits diabetic-like changes in the rat retina. Exp Eye Res. 2010 Aug; 91(2):171-9. Jiang Y, Walker RJ, Kern TS, Steinle JJ. PMID: 20493839; PMCID: PMC4319116.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    95. Overexpression of Bcl-2 in vascular endothelium inhibits the microvascular lesions of diabetic retinopathy. Am J Pathol. 2010 May; 176(5):2550-8. Kern TS, Du Y, Miller CM, Hatala DA, Levin LA. PMID: 20363911; PMCID: PMC2861119.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    96. Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):2158-64. Du Y, Tang J, Li G, Li G, Berti-Mattera L, Lee CA, Bartkowski D, Gale D, Monahan J, Niesman MR, Alton G, Kern TS. PMID: 20071676; PMCID: PMC2868413.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    97. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med. 2009 Nov; 15(11):1298-306. Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, Aiello LP, Kern TS, King GL. PMID: 19881493; PMCID: PMC3290906.
      View in: PubMed   Mentions: 202     Fields:    Translation:AnimalsCells
    98. Remodeling of retinal Fatty acids in an animal model of diabetes: a decrease in long-chain polyunsaturated fatty acids is associated with a decrease in fatty acid elongases Elovl2 and Elovl4. Diabetes. 2010 Jan; 59(1):219-27. Tikhonenko M, Lydic TA, Wang Y, Chen W, Opreanu M, Sochacki A, McSorley KM, Renis RL, Kern T, Jump DB, Reid GE, Busik JV. PMID: 19875612; PMCID: PMC2797925.
      View in: PubMed   Mentions: 71     Fields:    Translation:Animals
    99. Identification of primary retinal cells and ex vivo detection of proinflammatory molecules using flow cytometry. Mol Vis. 2009 Jul 17; 15:1383-9. Portillo JA, Okenka G, Kern TS, Subauste CS. PMID: 19626134; PMCID: PMC2713733.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    100. Increased basement membrane thickness, pericyte ghosts, and loss of retinal thickness and cells in dopamine beta hydroxylase knockout mice. Exp Eye Res. 2009 Jun; 88(6):1014-9. Steinle JJ, Kern TS, Thomas SA, McFadyen-Ketchum LS, Smith CP. PMID: 19176214.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    101. Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy. Front Biosci (Landmark Ed). 2009 01 01; 14(10):3974-87. Zheng L, Kern TS. PMID: 19273327.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    102. CD40 mediates retinal inflammation and neurovascular degeneration. J Immunol. 2008 Dec 15; 181(12):8719-26. Portillo JA, Van Grol J, Zheng L, Okenka G, Gentil K, Garland A, Carlson EC, Kern TS, Subauste CS. PMID: 19050292.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    103. Retinal ion regulation in a mouse model of diabetic retinopathy: natural history and the effect of Cu/Zn superoxide dismutase overexpression. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2351-8. Berkowitz BA, Gradianu M, Bissig D, Kern TS, Roberts R. PMID: 19074809; PMCID: PMC2688071.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    104. Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells. J Biol Chem. 2009 Feb 20; 284(8):4760-6. Shelton MD, Distler AM, Kern TS, Mieyal JJ. PMID: 19074435; PMCID: PMC2643491.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    105. Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E981-6. Han BG, Hao CM, Tchekneva EE, Wang YY, Lee CA, Ebrahim B, Harris RC, Kern TS, Wasserman DH, Breyer MD, Qi Z. PMID: 18664598; PMCID: PMC2575908.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    106. Sulfasalazine blocks the development of tactile allodynia in diabetic rats. Diabetes. 2008 Oct; 57(10):2801-8. Berti-Mattera LN, Kern TS, Siegel RE, Nemet I, Mitchell R. PMID: 18633115; PMCID: PMC2551692.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    107. Retinal ganglion cells in diabetes. J Physiol. 2008 Sep 15; 586(18):4401-8. Kern TS, Barber AJ. PMID: 18565995; PMCID: PMC2614025.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimalsCells
    108. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) meeting summary: Advances toward measuring diabetic retinopathy and neuropathy: from the bench to the clinic and back again (April 4-5, 2007, Baltimore, Maryland). J Diabetes Complications. 2009 May-Jun; 23(3):219-23. Kern TS, Berkowitz BA, Feldman EL. PMID: 18413183.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    109. 5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy. Diabetes. 2008 May; 57(5):1387-93. Gubitosi-Klug RA, Talahalli R, Du Y, Nadler JL, Kern TS. PMID: 18346986; PMCID: PMC4444435.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    110. Targets of tyrosine nitration in diabetic rat retina. Mol Cell Proteomics. 2008 May; 7(5):864-74. Zhan X, Du Y, Crabb JS, Gu X, Kern TS, Crabb JW. PMID: 18165258; PMCID: PMC2401337.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    111. Long-term, topical insulin administration increases the severity of retinal vascular pathology in streptozotocin-induced diabetic rats. Optometry. 2007 Nov; 78(11):574-81. Koevary SB, Nussey J, Kern TS. PMID: 17976619.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    112. Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy. Curr Eye Res. 2007 Oct; 32(10):883-9. Zhang JZ, Xi X, Gao L, Kern TS. PMID: 17963108.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    113. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci. 2007 Aug; 48(8):3805-11. Kanwar M, Chan PS, Kern TS, Kowluru RA. PMID: 17652755.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    114. Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetologia. 2007 Sep; 50(9):1987-1996. Zheng L, Du Y, Miller C, Gubitosi-Klug RA, Kern TS, Ball S, Berkowitz BA. PMID: 17583794.
      View in: PubMed   Mentions: 128     Fields:    Translation:Animals
    115. 6-Fluoro-6-deoxy-D-glucose as a tracer of glucose transport. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E237-45. Landau BR, Spring-Robinson CL, Muzic RF, Rachdaoui N, Rubin D, Berridge MS, Schumann WC, Chandramouli V, Kern TS, Ismail-Beigi F. PMID: 17405828.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    116. Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells. Diabetes. 2007 Apr; 56(4):960-7. Caballero S, Sengupta N, Afzal A, Chang KH, Li Calzi S, Guberski DL, Kern TS, Grant MB. PMID: 17395742; PMCID: PMC3746188.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimals
    117. Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy. J Biol Chem. 2007 Apr 27; 282(17):12467-74. Shelton MD, Kern TS, Mieyal JJ. PMID: 17324929.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    118. Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology. Diabetes. 2007 Feb; 56(2):373-9. Kern TS, Miller CM, Du Y, Zheng L, Mohr S, Ball SL, Kim M, Jamison JA, Bingaman DP. PMID: 17259381.
      View in: PubMed   Mentions: 71     Fields:    Translation:Animals
    119. Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy. Diabetes. 2007 Feb; 56(2):337-45. Zheng L, Howell SJ, Hatala DA, Huang K, Kern TS. PMID: 17259377.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    120. Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. Exp Diabetes Res. 2007; 2007:95103. Kern TS. PMID: 18274606; PMCID: PMC2216058.
      View in: PubMed   Mentions: 309     Fields:    Translation:AnimalsCells
    121. Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):361-7. Zheng L, Gong B, Hatala DA, Kern TS. PMID: 17197555.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    122. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes. 2006 Nov; 55(11):3112-20. Ohshiro Y, Ma RC, Yasuda Y, Hiraoka-Yamamoto J, Clermont AC, Isshiki K, Yagi K, Arikawa E, Kern TS, King GL. PMID: 17065350.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    123. Association between endothelin-1 and collagen deposition in db/db diabetic mouse kidneys. Biochem Biophys Res Commun. 2006 Jan 06; 339(1):65-70. Mishra R, Emancipator SN, Kern TS, Simonson MS. PMID: 16297859.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    124. Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4281-7. Feit-Leichman RA, Kinouchi R, Takeda M, Fan Z, Mohr S, Kern TS, Chen DF. PMID: 16249509.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    125. The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci. 2005 Jun; 46(6):2210-8. Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK. PMID: 15914643.
      View in: PubMed   Mentions: 243     Fields:    Translation:AnimalsCells
    126. Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am J Physiol Renal Physiol. 2005 Aug; 289(2):F420-30. Rosca MG, Mustata TG, Kinter MT, Ozdemir AM, Kern TS, Szweda LI, Brownlee M, Monnier VM, Weiss MF. PMID: 15814529.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    127. Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking. Diabetes. 2005 Feb; 54(2):517-26. Mustata GT, Rosca M, Biemel KM, Reihl O, Smith MA, Viswanathan A, Strauch C, Du Y, Tang J, Kern TS, Lederer MO, Brownlee M, Weiss MF, Monnier VM. PMID: 15677510.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    128. Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells. Biochem Biophys Res Commun. 2005 Jan 21; 326(3):548-53. Xi X, Gao L, Hatala DA, Smith DG, Codispoti MC, Gong B, Kern TS, Zhang JZ. PMID: 15596134.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    129. High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells. Kidney Int. 2005 Jan; 67(1):82-93. Mishra R, Emancipator SN, Kern T, Simonson MS. PMID: 15610231.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    130. Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. Diabetes. 2004 Nov; 53(11):2960-7. Zheng L, Szabó C, Kern TS. PMID: 15504977.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    131. Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats. Am J Physiol Regul Integr Comp Physiol. 2004 Oct; 287(4):R735-41. Du Y, Sarthy VP, Kern TS. PMID: 15371279.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    132. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004 Sep; 18(12):1450-2. Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H, Schraermeyer U, Kociok N, Fauser S, Kirchhof B, Kern TS, Adamis AP. PMID: 15231732.
      View in: PubMed   Mentions: 502     Fields:    Translation:AnimalsCells
    133. Comparison of glucose influx and blood flow in retina and brain of diabetic rats. J Cereb Blood Flow Metab. 2004 Apr; 24(4):449-57. Puchowicz MA, Xu K, Magness D, Miller C, Lust WD, Kern TS, LaManna JC. PMID: 15087714.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    134. Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney. Am J Physiol Renal Physiol. 2004 May; 286(5):F913-21. Mishra R, Emancipator SN, Miller C, Kern T, Simonson MS. PMID: 15075187.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    135. Regulation of the early subnormal retinal oxygenation response in experimental diabetes by inducible nitric oxide synthase. Diabetes. 2004 Jan; 53(1):173-8. Berkowitz BA, Luan H, Gupta RR, Pacheco D, Seidner A, Roberts R, Liggett J, Knoerzer DL, Connor JR, Du Y, Kern TS, Ito Y. PMID: 14693712.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    136. Hyperglycemia increases mitochondrial superoxide in retina and retinal cells. Free Radic Biol Med. 2003 Dec 01; 35(11):1491-9. Du Y, Miller CM, Kern TS. PMID: 14642397.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    137. Captopril inhibits glucose accumulation in retinal cells in diabetes. Invest Ophthalmol Vis Sci. 2003 Sep; 44(9):4001-5. Zhang JZ, Gao L, Widness M, Xi X, Kern TS. PMID: 12939321.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    138. A comprehensive analysis of the expression of crystallins in mouse retina. Mol Vis. 2003 Aug 28; 9:410-9. Xi J, Farjo R, Yoshida S, Kern TS, Swaroop A, Andley UP. PMID: 12949468.
      View in: PubMed   Mentions: 66     Fields:    Translation:Animals
    139. Non-uniform distribution of lesions and biochemical abnormalities within the retina of diabetic humans. Curr Eye Res. 2003 Jul; 27(1):7-13. Tang J, Mohr S, Du YD, Kern TS. PMID: 12868004.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    140. Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes. 2002 Jul; 51(7):2241-8. Romeo G, Liu WH, Asnaghi V, Kern TS, Lorenzi M. PMID: 12086956.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansCells
    141. Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients. Diabetes. 2002 Apr; 51(4):1172-9. Mohr S, Xi X, Tang J, Kern TS. PMID: 11916941.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    142. Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine. J Neurochem. 2002 Mar; 80(5):771-9. Du Y, Smith MA, Miller CM, Kern TS. PMID: 11948240.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    143. Correction of early subnormal superior hemiretinal DeltaPO(2) predicts therapeutic efficacy in experimental diabetic retinopathy. Invest Ophthalmol Vis Sci. 2001 Nov; 42(12):2964-9. Berkowitz BA, Ito Y, Kern TS, McDonald C, Hawkins R. PMID: 11687543.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    144. Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy. Diabetes. 2001 Aug; 50(8):1938-42. Kowluru RA, Tang J, Kern TS. PMID: 11473058.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    145. Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin. Diabetes. 2001 Jul; 50(7):1636-42. Kern TS, Engerman RL. PMID: 11423486.
      View in: PubMed   Mentions: 86     Fields:    Translation:Animals
    146. Retinal glutamate in diabetes and effect of antioxidants. Neurochem Int. 2001 Apr; 38(5):385-90. Kowluru RA, Engerman RL, Case GL, Kern TS. PMID: 11222918.
      View in: PubMed   Mentions: 67     Fields:    Translation:Animals
    147. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3972-8. Kern TS, Tang J, Mizutani M, Kowluru RA, Nagaraj RH, Romeo G, Podesta F, Lorenzi M. PMID: 11053301.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    148. Retina accumulates more glucose than does the embryologically similar cerebral cortex in diabetic rats. Diabetologia. 2000 Nov; 43(11):1417-23. Tang J, Zhu XW, Lust WD, Kern TS. PMID: 11126412.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    149. Abnormalities of retinal metabolism in diabetes or experimental galactosemia VIII. Prevention by aminoguanidine. Curr Eye Res. 2000 Oct; 21(4):814-9. Kowluru RA, Engerman RL, Kern TS. PMID: 11120572.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    150. Diabetes downregulates GLUT1 expression in the retina and its microvessels but not in the cerebral cortex or its microvessels. Diabetes. 2000 Jun; 49(6):1016-21. Badr GA, Tang J, Ismail-Beigi F, Kern TS. PMID: 10866055.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    151. Diabetes-induced metabolic abnormalities in myocardium: effect of antioxidant therapy. Free Radic Res. 2000 Jan; 32(1):67-74. Kowluru RA, Engerman RL, Kern TS. PMID: 10625218.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    152. Subnormal retinal oxygenation response precedes diabetic-like retinopathy. Invest Ophthalmol Vis Sci. 1999 Aug; 40(9):2100-5. Berkowitz BA, Kowluru RA, Frank RN, Kern TS, Hohman TC, Prakash M. PMID: 10440266.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    153. Abnormalities of retinal metabolism in diabetes or experimental galactosemia. VI. Comparison of retinal and cerebral cortex metabolism, and effects of antioxidant therapy. Free Radic Biol Med. 1999 Feb; 26(3-4):371-8. Kowluru RA, Engerman RL, Kern TS. PMID: 9895229.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    154. Glut1 and glut3 expression, but not capillary density, is increased by cobalt chloride in rat cerebrum and retina. Brain Res Mol Brain Res. 1999 Jan 22; 64(1):24-33. Badr GA, Zhang JZ, Tang J, Kern TS, Ismail-Beigi F. PMID: 9889305.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    155. Aldose reductase and the development of renal disease in diabetic dogs. J Diabetes Complications. 1999 Jan-Feb; 13(1):10-6. Kern TS, Engerman RL. PMID: 10232704.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    156. Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases. Diabetes. 1998 Mar; 47(3):464-9. Kowluru RA, Jirousek MR, Stramm L, Farid N, Engerman RL, Kern TS. PMID: 9519755.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    157. Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system. Free Radic Biol Med. 1997; 22(4):587-92. Kowluru RA, Kern TS, Engerman RL. PMID: 9013121.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    158. Abnormalities of retinal metabolism in diabetes or experimental galactosemia. III. Effects of antioxidants. Diabetes. 1996 Sep; 45(9):1233-7. Kowluru RA, Kern TS, Engerman RL, Armstrong D. PMID: 8772728.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    159. A mouse model of diabetic retinopathy. Arch Ophthalmol. 1996 Aug; 114(8):986-90. Kern TS, Engerman RL. PMID: 8694735.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    160. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest. 1996 Jun 15; 97(12):2883-90. Mizutani M, Kern TS, Lorenzi M. PMID: 8675702; PMCID: PMC507384.
      View in: PubMed   Mentions: 256     Fields:    Translation:HumansAnimals
    161. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science. 1996 May 03; 272(5262):728-31. Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell SE, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL. PMID: 8614835.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    162. Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen. Diabetes. 1996 May; 45(5):587-94. Nagaraj RH, Kern TS, Sell DR, Fogarty J, Engerman RL, Monnier VM. PMID: 8621008.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    163. Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia. Arch Ophthalmol. 1996 Mar; 114(3):306-10. Kern TS, Engerman RL. PMID: 8600891.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    164. Retinopathy in animal models of diabetes. Diabetes Metab Rev. 1995 Jul; 11(2):109-20. Engerman RL, Kern TS. PMID: 7555563.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    165. Vascular lesions in diabetes are distributed non-uniformly within the retina. Exp Eye Res. 1995 May; 60(5):545-9. Kern TS, Engerman RL. PMID: 7615020.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    166. Retinopathy in galactosemic dogs continues to progress after cessation of galactosemia. Arch Ophthalmol. 1995 Mar; 113(3):355-8. Engerman RL, Kern TS. PMID: 7887850.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    167. Galactose-induced retinal microangiopathy in rats. Invest Ophthalmol Vis Sci. 1995 Feb; 36(2):490-6. Kern TS, Engerman RL. PMID: 7843917.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    168. Comparison of retinal lesions in alloxan-diabetic rats and galactose-fed rats. Curr Eye Res. 1994 Dec; 13(12):863-7. Kern TS, Engerman RL. PMID: 7720392.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    169. Abnormalities of retinal metabolism in diabetes or galactosemia. II. Comparison of gamma-glutamyl transpeptidase in retina and cerebral cortex, and effects of antioxidant therapy. Curr Eye Res. 1994 Dec; 13(12):891-6. Kowluru R, Kern TS, Engerman RL. PMID: 7720397.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    170. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes. 1994 Sep; 43(9):1122-9. Xia P, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL. PMID: 8070612.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    171. Abnormalities of retinal metabolism in diabetes or galactosemia: ATPases and glutathione. Invest Ophthalmol Vis Sci. 1994 Jun; 35(7):2962-7. Kern TS, Kowluru RA, Engerman RL. PMID: 8206713.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    172. Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs. Diabetologia. 1994 Feb; 37(2):141-4. Engerman RL, Kern TS, Larson ME. PMID: 8163047.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    173. Capillary basement membrane in retina, kidney, and muscle of diabetic dogs and galactosemic dogs and its response to 5 years aldose reductase inhibition. J Diabetes Complications. 1993 Oct-Dec; 7(4):241-5. Engerman RL, Kern TS, Garment MB. PMID: 8219367.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    174. Retinal polyol and myo-inositol in galactosemic dogs given an aldose-reductase inhibitor. Invest Ophthalmol Vis Sci. 1991 Dec; 32(13):3175-7. Kern TS, Engerman RL. PMID: 1748548.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    175. Arrest of glomerulopathy in diabetic dogs by improved glycaemic control. Diabetologia. 1990 Sep; 33(9):522-5. Kern TS, Engerman RL. PMID: 2253827.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    176. Urinary protein excretion rates in experimentally diabetic dogs and experimentally galactosaemic dogs. Diabetologia. 1988 Dec; 31(12):928-32. Kern TS, Engerman RL. PMID: 3240845.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    177. Progression of incipient diabetic retinopathy during good glycemic control. Diabetes. 1987 Jul; 36(7):808-12. Engerman RL, Kern TS. PMID: 3556280.
      View in: PubMed   Mentions: 156     Fields:    Translation:Animals
    178. Is diabetic retinopathy preventable? Int Ophthalmol Clin. 1987; 27(4):225-9. Engerman RL, Kern TS. PMID: 3319932.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    179. Hyperglycemia as a cause of diabetic retinopathy. Metabolism. 1986 Apr; 35(4 Suppl 1):20-3. Engerman RL, Kern TS. PMID: 3083205.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    180. Microvascular metabolism in diabetes. Metabolism. 1986 Apr; 35(4 Suppl 1):24-7. Kern TS, Engerman RL. PMID: 3083206.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    181. Diabetic retinopathy: is it a consequence of hyperglycaemia? Diabet Med. 1985 May; 2(3):200-3. Engerman RL, Kern TS. PMID: 2952421.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    182. Hexitol production by canine retinal microvessels. Invest Ophthalmol Vis Sci. 1985 Mar; 26(3):382-4. Kern TS, Engerman RL. PMID: 3972519.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    183. Experimental galactosemia produces diabetic-like retinopathy. Diabetes. 1984 Jan; 33(1):97-100. Engerman RL, Kern TS. PMID: 6360771.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    With one click, see people who:

    Run Clinical Trials

    See more options in the Advanced Search tab

    Timothy's Networks
    Concepts (685)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (6)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCI Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).
    This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB03.

    Copyright © The Regents of the University of California