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Timothy Scott Kern

Title(s)Professor, Ophthalmology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-5324
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    Collapse Research Activities and Funding
    BLR&D Research Career Scientist Application
    VA IK6BX003604Oct 1, 2016 - Sep 30, 2021
    Role: Principal Investigator
    Novel therapies to inhibit diabetic retinopathy
    NIH/NEI R24EY024864Apr 1, 2015 - Mar 31, 2020
    Role: Principal Investigator
    Acetylation and diabetic retinopathy
    VA I01BX002117Apr 1, 2014 - Mar 31, 2018
    Role: Principal Investigator
    Role of Photoreceptors in the Pathogenesis of Diabetic Retinopathy
    NIH/NEI R01EY022938Sep 1, 2013 - May 31, 2022
    Role: Principal Investigator
    Global Characterization of Lysine Acetylation in Diabetic Retina
    NIH/NEI R21EY021595Jan 1, 2012 - Dec 31, 2013
    Role: Co-Principal Investigator
    PATHOGENESIS OF DIABETIC MICROVASCULAR COMPLICATIONS
    NIH/NIDDK P01DK057733Sep 1, 2000 - Aug 31, 2005
    Role: Principal Investigator
    Study of diabetic retinopathy
    NIH/NEI R56EY000300Dec 1, 1977 - Sep 29, 2010
    Role: Principal Investigator
    Study of diabetic retinopathy
    NIH/NEI R01EY000300Dec 1, 1977 - Sep 29, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion. Invest Ophthalmol Vis Sci. 2020 Jun 03; 61(6):8. Dreffs A, Lin CM, Liu X, Shanmugam S, Abcouwer SF, Kern TS, Antonetti DA. PMID: 32492112.
      View in: PubMed   Mentions:    Fields:    
    2. Fatty acid oxidation and photoreceptor metabolic needs. J Lipid Res. 2020 Feb 24. Fu Z, Kern TS, Hellström A, Smith L. PMID: 32094231.
      View in: PubMed   Mentions:    Fields:    
    3. Dyslipidemia in retinal metabolic disorders. EMBO Mol Med. 2019 10; 11(10):e10473. Fu Z, Chen CT, Cagnone G, Heckel E, Sun Y, Cakir B, Tomita Y, Huang S, Li Q, Britton W, Cho SS, Kern TS, Hellström A, Joyal JS, Smith LE. PMID: 31486227.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Pathophysiology of Diabetic Retinopathy: Contribution and Limitations of Laboratory Research. Ophthalmic Res. 2019; 62(4):196-202. Kern TS, Antonetti DA, Smith LEH. PMID: 31362288.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    5. The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice. Invest Ophthalmol Vis Sci. 2018 04 01; 59(5):2042-2053. Nahomi RB, Sampathkumar S, Myers AM, Elghazi L, Smith DG, Tang J, Lee CA, Kern TS, Nagaraj RH, Fort PE. PMID: 29677366.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Do photoreceptor cells cause the development of retinal vascular disease? Vision Res. 2017 10; 139:65-71. Kern TS. PMID: 28438678.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Diabetic Retinopathy: Retina-Specific Methods for Maintenance of Diabetic Rodents and Evaluation of Vascular Histopathology and Molecular Abnormalities. Curr Protoc Mouse Biol. 2015 Sep 01; 5(3):247-270. Veenstra A, Liu H, Lee CA, Du Y, Tang J, Kern TS. PMID: 26331759.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    8. Retinylamine Benefits Early Diabetic Retinopathy in Mice. J Biol Chem. 2015 Aug 28; 290(35):21568-79. Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, von Lintig J, Palczewski K, Kern TS. PMID: 26139608.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    9. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May; 29(5):2194-204. Du Y, Cramer M, Lee CA, Tang J, Muthusamy A, Antonetti DA, Jin H, Palczewski K, Kern TS. PMID: 25667222.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    10. Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy. PLoS One. 2014; 9(1):e84671. Rajashekhar G, Ramadan A, Abburi C, Callaghan B, Traktuev DO, Evans-Molina C, Maturi R, Harris A, Kern TS, March KL. PMID: 24416262.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    11. Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy. Invest Ophthalmol Vis Sci. 2012 Aug 13; 53(9):5520-6. Li Y, Smith D, Li Q, Sheibani N, Huang S, Kern T, Nagaraj RH, Lin F. PMID: 22786897.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    12. Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice. Nutr Diabetes. 2012 Jul 23; 2:e36. Sapieha P, Chen J, Stahl A, Seaward MR, Favazza TL, Juan AM, Hatton CJ, Joyal JS, Krah NM, Dennison RJ, Tang J, Kern TS, Akula JD, Smith LE. PMID: 23448719.
      View in: PubMed   Mentions: 13     Fields:    
    13. The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. Diabetes. 2011 Sep; 60(9):2370-8. Opreanu M, Tikhonenko M, Bozack S, Lydic TA, Reid GE, McSorley KM, Sochacki A, Perez GI, Esselman WJ, Kern T, Kolesnick R, Grant MB, Busik JV. PMID: 21771974.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    14. Inflammation in diabetic retinopathy. Prog Retin Eye Res. 2011 Sep; 30(5):343-58. Tang J, Kern TS. PMID: 21635964.
      View in: PubMed   Mentions: 277     Fields:    Translation:HumansAnimalsCells
    15. The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci. 2005 Jun; 46(6):2210-8. Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK. PMID: 15914643.
      View in: PubMed   Mentions: 181     Fields:    Translation:AnimalsCells
    16. Hyperglycemia as a cause of diabetic retinopathy. Metabolism. 1986 Apr; 35(4 Suppl 1):20-3. Engerman RL, Kern TS. PMID: 3083205.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    17. Microvascular metabolism in diabetes. Metabolism. 1986 Apr; 35(4 Suppl 1):24-7. Kern TS, Engerman RL. PMID: 3083206.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
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