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Benmohamed, Lbachir

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentOphthalmology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-8937
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    Collapse Research 
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    A NOVEL SELF-ASSEMBLING PROTEIN NANOPARTICLES-BASED GENITAL HERPES VACCINE
    NIH/NIAID R41AI138764Apr 1, 2018 - Mar 31, 2019
    Role: Principal Investigator
    Mechanisms of CD8+ T Cell Dynamics in Recurrent Ocular Herpetic Disease
    NIH/NEI R01EY026103Aug 1, 2016 - Jul 31, 2020
    Role: Principal Investigator
    LAT-HVEM Interactions Effect HSV-1 Latency/Reactivation
    NIH/NIAID R21AI110902Jul 1, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Blockade of T-cell Co-Inhibitory Pathways & Immunotherapy to Prevent Ocular Herpe
    NIH/NEI R01EY024618Sep 3, 2014 - Aug 31, 2017
    Role: Principal Investigator
    Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits
    NIH/NEI R01EY019896Sep 1, 2010 - Mar 31, 2020
    Role: Principal Investigator
    Ocular Mucosal Immunity Induced by HSV-1 Lipopeptide
    NIH/NEI R01EY014900Sep 30, 2003 - Mar 31, 2015
    Role: Principal Investigator
    Interaction of HSV-1 LAT Gene &Dendritic Cells Function
    NIH/NEI R03EY014017Apr 1, 2002 - Mar 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Srivastava R, Coulon PG, Roy S, Chilukuri S, Garg S, BenMohamed L. Phenotypic and Functional Signatures of Herpes Simplex Virus-Specific Effector Memory CD73+CD45RAhighCCR7lowCD8+ TEMRA and CD73+CD45RAlowCCR7lowCD8+ TEM Cells Are Associated with Asymptomatic Ocular Herpes. J Immunol. 2018 Sep 10. PMID: 30201808.
      View in: PubMed
    2. Khan AA, Srivastava R, Vahed H, Roy S, Walia SS, Kim GJ, Fouladi MA, Yamada T, Ly VT, Lam C, Lou A, Nguyen V, Boldbaatar U, Geertsema R, Fraser NW, BenMohamed L. Human Asymptomatic Epitope Peptide/CXCL10-Based Prime/Pull Vaccine Induces Herpes Simplex Virus-Specific Gamma Interferon-Positive CD107+ CD8+ T Cells That Infiltrate the Cornea and Trigeminal Ganglia of Humanized HLA Transgenic Rabbits and Protect against Ocular Herpes Challenge. J Virol. 2018 Jun 13. PMID: 29899087.
      View in: PubMed
    3. Esteves PJ, Abrantes J, Baldauf HM, BenMohamed L, Chen Y, Christensen N, González-Gallego J, Giacani L, Hu J, Kaplan G, Keppler OT, Knight KL, Kong XP, Lanning DK, Le Pendu J, de Matos AL, Liu J, Liu S, Lopes AM, Lu S, Lukehart S, Manabe YC, Neves F, McFadden G, Pan R, Peng X, de Sousa-Pereira P, Pinheiro A, Rahman M, Ruvoën-Clouet N, Subbian S, Tuñón MJ, van der Loo W, Vaine M, Via LE, Wang S, Mage R. The wide utility of rabbits as models of human diseases. Exp Mol Med. 2018 May 22; 50(5):66. PMID: 29789565.
      View in: PubMed
    4. Lopes PP, Todorov G, Pham TT, Nesburn AB, Bahraoui E, BenMohamed L. Laser Adjuvant-Assisted Peptide Vaccine Promotes Skin Mobilization of Dendritic Cells and Enhances Protective CD8+ TEM and TRM Cell Responses against Herpesvirus Infection and Disease. J Virol. 2018 04 15; 92(8). PMID: 29437976.
      View in: PubMed
    5. Srivastava R, Hernández-Ruiz M, Khan AA, Fouladi MA, Kim GJ, Ly VT, Yamada T, Lam C, Sarain SAB, Boldbaatar U, Zlotnik A, Bahraoui E, BenMohamed L. CXCL17 Chemokine-Dependent Mobilization of CXCR8+CD8+ Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes. J Immunol. 2018 Apr 15; 200(8):2915-2926. PMID: 29549178.
      View in: PubMed
    6. Srivastava R, Khan AA, Chilukuri S, Syed SA, Tran TT, Furness J, Bahraoui E, BenMohamed L. CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8+ TEM and CD8+ TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease. J Virol. 2017 07 15; 91(14). PMID: 28468883.
      View in: PubMed
    7. Khan AA, Srivastava R, Chentoufi AA, Kritzer E, Chilukuri S, Garg S, Yu DC, Vahed H, Huang L, Syed SA, Furness JN, Tran TT, Anthony NB, McLaren CE, Sidney J, Sette A, Noelle RJ, BenMohamed L. Bolstering the Number and Function of HSV-1-Specific CD8+ Effector Memory T Cells and Tissue-Resident Memory T Cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease. J Immunol. 2017 07 01; 199(1):186-203. PMID: 28539429.
      View in: PubMed
    8. Agrawal S, Srivastava R, Rahmatpanah F, Madiraju C, BenMohamed L, Agrawal A. Airway epithelial cells enhance the immunogenicity of human myeloid dendritic cells under steady state. Clin Exp Immunol. 2017 Sep; 189(3):279-289. PMID: 28470729.
      View in: PubMed
    9. Nalbandian A, Khan AA, Srivastava R, Llewellyn KJ, Tan B, Shukr N, Fazli Y, Kimonis VE, BenMohamed L. Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy. Inflammation. 2017 Feb; 40(1):21-41. PMID: 27730320.
      View in: PubMed
    10. Srivastava R, Khan AA, Garg S, Syed SA, Furness JN, Vahed H, Pham T, Yu HT, Nesburn AB, BenMohamed L. Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44high CD62Llow CD8+ TEM Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpesvirus Infection. J Virol. 2017 Jan 15; 91(2). PMID: 27847359.
      View in: PubMed
    11. Nesburn AB, BenMohamed L. A Tribute to Professor Steven L. Wechsler (1948-2016): The Man and the Scientist. Curr Eye Res. 2017 01; 42(1):161-162. PMID: 27911113.
      View in: PubMed
    12. Planès R, Ben Haij N, Leghmari K, Serrero M, BenMohamed L, Bahraoui E. HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes. J Virol. 2016 07 01; 90(13):5886-5898. PMID: 27053552.
      View in: PubMed
    13. Srivastava R, Dervillez X, Khan AA, Chentoufi AA, Chilukuri S, Shukr N, Fazli Y, Ong NN, Afifi RE, Osorio N, Geertsema R, Nesburn AB, Wechsler SL, BenMohamed L. The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits. J Virol. 2016 Apr; 90(8):3913-3928. PMID: 26842468.
      View in: PubMed
    14. Jester JV, Morishige N, BenMohamed L, Brown DJ, Osorio N, Hsiang C, Perng GC, Jones C, Wechsler SL. Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis. Cornea. 2016 Jan; 35(1):81-8. PMID: 26555580; PMCID: PMC4674384 [Available on 01/01/17].
    15. BenMohamed L, Osorio N, Khan AA, Srivastava R, Huang L, Krochmal JJ, Garcia JM, Simpson JL, Wechsler SL. Prior Corneal Scarification and Injection of Immune Serum are Not Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice. Curr Eye Res. 2016 06; 41(6):747-56. PMID: 26398722.
      View in: PubMed
    16. Yin Z, Chowdhury S, McKay C, Baniel C, Wright WS, Bentley P, Kaczanowska K, Gildersleeve JC, Finn MG, BenMohamed L, Huang X. Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-Based Anticancer Vaccine. ACS Chem Biol. 2015 Oct 16; 10(10):2364-72. PMID: 26262839; PMCID: PMC4725323 [Available on 10/16/16].
    17. Llewellyn KJ, Walker N, Nguyen C, Tan B, BenMohamed L, Kimonis VE, Nalbandian A. A Fine Balance of Dietary Lipids Improves Pathology of a Murine Model of VCP-Associated Multisystem Proteinopathy. PLoS One. 2015; 10(7):e0131995. PMID: 26134519; PMCID: PMC4489713.
    18. Khan AA, Srivastava R, Chentoufi AA, Geertsema R, Thai NT, Dasgupta G, Osorio N, Kalantari M, Nesburn AB, Wechsler SL, BenMohamed L. Therapeutic immunization with a mixture of herpes simplex virus 1 glycoprotein D-derived “asymptomatic” human CD8+ T-cell epitopes decreases spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low frequency of local PD-1+ TIM-3+ CD8+ exhausted T cells. J Virol. 2015 Jul; 89(13):6619-32. PMID: 25878105; PMCID: PMC4468472.
    19. Ben Haij N, Planès R, Leghmari K, Serrero M, Delobel P, Izopet J, BenMohamed L, Bahraoui E. HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation of NF-?B Pathway. PLoS One. 2015; 10(6):e0129425. PMID: 26090662.
      View in: PubMed
    20. Carpenter D, Hsiang C, Jiang X, Osorio N, BenMohamed L, Jones C, Wechsler SL. The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT). J Neurovirol. 2015 Oct; 21(5):568-75. PMID: 26071090.
      View in: PubMed
    21. Jiang X, Brown D, Osorio N, Hsiang C, BenMohamed L, Wechsler SL. Increased neurovirulence and reactivation of the herpes simplex virus type 1 latency-associated transcript (LAT)-negative mutant dLAT2903 with a disrupted LAT miR-H2. J Neurovirol. 2016 Feb; 22(1):38-49. PMID: 26069184; PMCID: PMC4676951 [Available on 02/01/17].
    22. Srivastava R, Khan AA, Huang J, Nesburn AB, Wechsler SL, BenMohamed L. A Herpes Simplex Virus Type 1 Human Asymptomatic CD8+ T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a "Humanized" HLA Transgenic Rabbit Model. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):4013-28. PMID: 26098469; PMCID: PMC4477261.
    23. BenMohamed L, Osorio N, Srivastava R, Khan AA, Simpson JL, Wechsler SL. Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation. J Neurovirol. 2015 Oct; 21(5):508-17. PMID: 26002839; PMCID: PMC4618093 [Available on 10/01/16].
    24. Perng GC, Osorio N, Jiang X, Geertsema R, Hsiang C, Brown D, BenMohamed L, Wechsler SL. Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. Curr Eye Res. 2016; 41(3):284-91. PMID: 25859798.
      View in: PubMed
    25. Jiang X, Brown D, Osorio N, Hsiang C, Li L, Chan L, BenMohamed L, Wechsler SL. A herpes simplex virus type 1 mutant disrupted for microRNA H2 with increased neurovirulence and rate of reactivation. J Neurovirol. 2015 Apr; 21(2):199-209. PMID: 25645379; PMCID: PMC4375036.
    26. Srivastava R, Khan AA, Spencer D, Vahed H, Lopes PP, Thai NT, Wang C, Pham TT, Huang J, Scarfone VM, Nesburn AB, Wechsler SL, BenMohamed L. HLA-A02:01-restricted epitopes identified from the herpes simplex virus tegument protein VP11/12 preferentially recall polyfunctional effector memory CD8+ T cells from seropositive asymptomatic individuals and protect humanized HLA-A*02:01 transgenic mice against ocular herpes. J Immunol. 2015 Mar 01; 194(5):2232-48. PMID: 25617474; PMCID: PMC4340763.
    27. Khan AA, Srivastava R, Spencer D, Garg S, Fremgen D, Vahed H, Lopes PP, Pham TT, Hewett C, Kuang J, Ong N, Huang L, Scarfone VM, Nesburn AB, Wechsler SL, BenMohamed L. Phenotypic and functional characterization of herpes simplex virus glycoprotein B epitope-specific effector and memory CD8+ T cells from symptomatic and asymptomatic individuals with ocular herpes. J Virol. 2015 Apr; 89(7):3776-92. PMID: 25609800; PMCID: PMC4403403.
    28. Farid M, Agrawal A, Fremgen D, Tao J, Chuyi H, Nesburn AB, BenMohamed L. Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease. Ocul Immunol Inflamm. 2016 Jun; 24(3):327-47. PMID: 25535823; PMCID: PMC4478284.
    29. Kuo T, Wang C, Badakhshan T, Chilukuri S, BenMohamed L. The challenges and opportunities for the development of a T-cell epitope-based herpes simplex vaccine. Vaccine. 2014 Nov 28; 32(50):6733-45. PMID: 25446827; PMCID: PMC4254646.
    30. Richichi B, Thomas B, Fiore M, Bosco R, Qureshi H, Nativi C, Renaudet O, BenMohamed L. A cancer therapeutic vaccine based on clustered Tn-antigen mimetics induces strong antibody-mediated protective immunity. Angew Chem Int Ed Engl. 2014 Oct 27; 53(44):11917-20. PMID: 25168881; PMCID: PMC4564297.
    31. Samandary S, Kridane-Miledi H, Sandoval JS, Choudhury Z, Langa-Vives F, Spencer D, Chentoufi AA, Lemonnier FA, BenMohamed L. Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: implication for the development of an universal CD8+ T-cell epitope-based vaccine. Hum Immunol. 2014 Aug; 75(8):715-29. PMID: 24798939; PMCID: PMC4119854.
    32. Prakash S, Agrawal S, Vahed H, Ngyuen M, BenMohamed L, BenMohamad L, Gupta S, Agrawal A. Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. Mucosal Immunol. 2014 Nov; 7(6):1386-94. PMID: 24759206; PMCID: PMC4205198.
    33. Planès R, BenMohamed L, Leghmari K, Delobel P, Izopet J, Bahraoui E. HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms. J Virol. 2014 Jun; 88(12):6672-89. PMID: 24696476; PMCID: PMC4054384.
    34. Khan AA, Srivastava R, Lopes PP, Wang C, Pham TT, Cochrane J, Thai NT, Gutierrez L, Benmohamed L. Asymptomatic memory CD8+ T cells: from development and regulation to consideration for human vaccines and immunotherapeutics. Hum Vaccin Immunother. 2014; 10(4):945-63. PMID: 24499824; PMCID: PMC4896594.
    35. Dervillez X, Qureshi H, Chentoufi AA, Khan AA, Kritzer E, Yu DC, Diaz OR, Gottimukkala C, Kalantari M, Villacres MC, Scarfone VM, McKinney DM, Sidney J, Sette A, Nesburn AB, Wechsler SL, BenMohamed L. Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes. J Immunol. 2013 Nov 15; 191(10):5124-38. PMID: 24101547; PMCID: PMC4057607.
    36. Dec E, Rana P, Katheria V, Dec R, Khare M, Nalbandian A, Leu SY, Radom-Aizik S, Llewellyn K, BenMohamed L, Zaldivar F, Kimonis V. Cytokine profiling in patients with VCP-associated disease. Clin Transl Sci. 2014 Feb; 7(1):29-32. PMID: 24119107; PMCID: PMC4057603.
    37. Boucherma R, Kridane-Miledi H, Bouziat R, Rasmussen M, Gatard T, Langa-Vives F, Lemercier B, Lim A, Bérard M, Benmohamed L, Buus S, Rooke R, Lemonnier FA. HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses. J Immunol. 2013 Jul 15; 191(2):583-93. PMID: 23776170; PMCID: PMC4057605.
    38. Yin Z, Comellas-Aragones M, Chowdhury S, Bentley P, Kaczanowska K, Benmohamed L, Gildersleeve JC, Finn MG, Huang X. Boosting immunity to small tumor-associated carbohydrates with bacteriophage qß capsids. ACS Chem Biol. 2013; 8(6):1253-62. PMID: 23505965; PMCID: PMC3735802.
    39. Chentoufi AA, BenMohamed L, Van De Perre P, Ashkar AA. Immunity to ocular and genital herpes simplex viruses infections. Clin Dev Immunol. 2012; 2012:732546. PMID: 23326289; PMCID: PMC3541643.
    40. Chentoufi AA, Benmohamed L. Mucosal herpes immunity and immunopathology to ocular and genital herpes simplex virus infections. Clin Dev Immunol. 2012; 2012:149135. PMID: 23320014; PMCID: PMC3540975.
    41. Zhang X, Dervillez X, Chentoufi AA, Badakhshan T, Bettahi I, Benmohamed L. Targeting the genital tract mucosa with a lipopeptide/recombinant adenovirus prime/boost vaccine induces potent and long-lasting CD8+ T cell immunity against herpes: importance of MyD88. J Immunol. 2012 Nov 01; 189(9):4496-509. PMID: 23018456; PMCID: PMC3478413.
    42. Chentoufi AA, Dervillez X, Dasgupta G, Nguyen C, Kabbara KW, Jiang X, Nesburn AB, Wechsler SL, Benmohamed L. The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells. Viral Immunol. 2012 Jun; 25(3):204-15. PMID: 22512280; PMCID: PMC3366336.
    43. Dervillez X, Gottimukkala C, Kabbara KW, Nguyen C, Badakhshan T, Kim SM, Nesburn AB, Wechsler SL, Benmohamed L. Future of an "Asymptomatic" T-cell Epitope-Based Therapeutic Herpes Simplex Vaccine. Future Virol. 2012 Apr 01; 7(4):371-378. PMID: 22701511.
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    44. Chentoufi AA, Kritzer E, Yu DM, Nesburn AB, Benmohamed L. Towards a rational design of an asymptomatic clinical herpes vaccine: the old, the new, and the unknown. Clin Dev Immunol. 2012; 2012:187585. PMID: 22548113; PMCID: PMC3324142.
    45. Dasgupta G, Chentoufi AA, Kalantari M, Falatoonzadeh P, Chun S, Lim CH, Felgner PL, Davies DH, BenMohamed L. Immunodominant "asymptomatic" herpes simplex virus 1 and 2 protein antigens identified by probing whole-ORFome microarrays with serum antibodies from seropositive asymptomatic versus symptomatic individuals. J Virol. 2012 Apr; 86(8):4358-69. PMID: 22318137; PMCID: PMC3318627.
    46. Kalantari-Dehaghi M, Chun S, Chentoufi AA, Pablo J, Liang L, Dasgupta G, Molina DM, Jasinskas A, Nakajima-Sasaki R, Felgner J, Hermanson G, BenMohamed L, Felgner PL, Davies DH. Discovery of potential diagnostic and vaccine antigens in herpes simplex virus 1 and 2 by proteome-wide antibody profiling. J Virol. 2012 Apr; 86(8):4328-39. PMID: 22318154; PMCID: PMC3318641.
    47. Chentoufi AA, Dervillez X, Rubbo PA, Kuo T, Zhang X, Nagot N, Tuaillon E, Van De Perre P, Nesburn AB, Benmohamed L. Current trends in negative immuno-synergy between two sexually transmitted infectious viruses: HIV-1 and HSV-1/2. Curr Trends Immunol. 2012; 13:51-68. PMID: 23355766.
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    48. Rubbo PA, Tuaillon E, Nagot N, Chentoufi AA, Bolloré K, Reynes J, Vendrell JP, BenMohamed L, Van De Perre P. HIV-1 infection impairs HSV-specific CD4(+) and CD8(+) T-cell response by reducing Th1 cytokines and CCR5 ligand secretion. J Acquir Immune Defic Syndr. 2011 Sep 01; 58(1):9-17. PMID: 21646911.
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    49. Allen SJ, Mott KR, Chentoufi AA, BenMohamed L, Wechsler SL, Ballantyne CM, Ghiasi H. CD11c controls herpes simplex virus 1 responses to limit virus replication during primary infection. J Virol. 2011 Oct; 85(19):9945-55. PMID: 21775452; PMCID: PMC3196403.
    50. Chentoufi AA, Kritzer E, Tran MV, Dasgupta G, Lim CH, Yu DC, Afifi RE, Jiang X, Carpenter D, Osorio N, Hsiang C, Nesburn AB, Wechsler SL, BenMohamed L. The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism. J Virol. 2011 Sep; 85(17):9127-38. PMID: 21715478; PMCID: PMC3165846.
    51. Dasgupta G, BenMohamed L. Of mice and not humans: how reliable are animal models for evaluation of herpes CD8(+)-T cell-epitopes-based immunotherapeutic vaccine candidates? Vaccine. 2011 Aug 11; 29(35):5824-36. PMID: 21718746; PMCID: PMC3159167.
    52. Dasgupta G, Chentoufi AA, You S, Falatoonzadeh P, Urbano LA, Akhtarmalik A, Nguyen K, Ablabutyan L, Nesburn AB, BenMohamed L. Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses. Invest Ophthalmol Vis Sci. 2011 May 17; 52(6):3321-33. PMID: 21273544; PMCID: PMC3109031.
    53. Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H. The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. J Virol. 2011 May; 85(9):4184-97. PMID: 21307196; PMCID: PMC3126262.
    54. Perlaza BL, Sauzet JP, Brahimi K, BenMohamed L, Druilhe P. Interferon-?, a valuable surrogate marker of Plasmodium falciparum pre-erythrocytic stages protective immunity. Malar J. 2011 Feb 08; 10:27. PMID: 21303495; PMCID: PMC3046914.
    55. Jiang X, Chentoufi AA, Hsiang C, Carpenter D, Osorio N, BenMohamed L, Fraser NW, Jones C, Wechsler SL. The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing. J Virol. 2011 Mar; 85(5):2325-32. PMID: 21177822; PMCID: PMC3067767.
    56. Chentoufi AA, BenMohamed L. Future viral vectors for the delivery of asymptomatic herpes epitope-based immunotherapeutic vaccines. Future Virol. 2010 Sep 01; 5(5):525-528. PMID: 21442030.
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    57. Renaudet O, Dasgupta G, Bettahi I, Shi A, Nesburn AB, Dumy P, BenMohamed L. Linear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunity. PLoS One. 2010 Jun 21; 5(6):e11216. PMID: 20574522; PMCID: PMC2888579.
    58. Chentoufi AA, Dasgupta G, Christensen ND, Hu J, Choudhury ZS, Azeem A, Jester JV, Nesburn AB, Wechsler SL, BenMohamed L. A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitope-based vaccines against ocular herpes. J Immunol. 2010 Mar 01; 184(5):2561-71. PMID: 20124097; PMCID: PMC3752373.
    59. Chentoufi AA, Dasgupta G, Nesburn AB, Bettahi I, Binder NR, Choudhury ZS, Chamberlain WD, Wechsler SL, BenMohamed L. Nasolacrimal duct closure modulates ocular mucosal and systemic CD4(+) T-cell responses induced following topical ocular or intranasal immunization. Clin Vaccine Immunol. 2010 Mar; 17(3):342-53. PMID: 20089796; PMCID: PMC2837957.
    60. Dasgupta G, Nesburn AB, Wechsler SL, BenMohamed L. Developing an asymptomatic mucosal herpes vaccine: the present and the future. Future Microbiol. 2010 Jan; 5(1):1-4. PMID: 20020824; PMCID: PMC4512283.
    61. Chentoufi AA, Nesburn AB, BenMohamed L. Recent advances in multivalent self adjuvanting glycolipopeptide vaccine strategies against breast cancer. Arch Immunol Ther Exp (Warsz). 2009 Nov-Dec; 57(6):409-23. PMID: 19866342.
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    62. Dasgupta G, Chentoufi AA, Nesburn AB, Wechsler SL, BenMohamed L. New concepts in herpes simplex virus vaccine development: notes from the battlefield. Expert Rev Vaccines. 2009 Aug; 8(8):1023-35. PMID: 19627185; PMCID: PMC2760836.
    63. Mott KR, Chentoufi AA, Carpenter D, BenMohamed L, Wechsler SL, Ghiasi H. The role of a glycoprotein K (gK) CD8+ T-cell epitope of herpes simplex virus on virus replication and pathogenicity. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2903-12. PMID: 19168902.
      View in: PubMed
    64. Zhang X, Chentoufi AA, Dasgupta G, Nesburn AB, Wu M, Zhu X, Carpenter D, Wechsler SL, You S, BenMohamed L. A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge. Mucosal Immunol. 2009 Mar; 2(2):129-143. PMID: 19129756; PMCID: PMC4509510.
    65. Mott KR, Bresee CJ, Allen SJ, BenMohamed L, Wechsler SL, Ghiasi H. Level of herpes simplex virus type 1 latency correlates with severity of corneal scarring and exhaustion of CD8+ T cells in trigeminal ganglia of latently infected mice. J Virol. 2009 Mar; 83(5):2246-54. PMID: 19091870; PMCID: PMC2643740.
    66. Chentoufi AA, Binder NR, Berka N, Durand G, Nguyen A, Bettahi I, Maillère B, BenMohamed L. Asymptomatic human CD4+ cytotoxic T-cell epitopes identified from herpes simplex virus glycoprotein B. J Virol. 2008 Dec; 82(23):11792-802. PMID: 18799581; PMCID: PMC2583686.
    67. Zhang X, Castelli FA, Zhu X, Wu M, Maillère B, BenMohamed L. Gender-dependent HLA-DR-restricted epitopes identified from herpes simplex virus type 1 glycoprotein D. Clin Vaccine Immunol. 2008 Sep; 15(9):1436-49. PMID: 18667634; PMCID: PMC2546687.
    68. Bettahi I, Dasgupta G, Renaudet O, Chentoufi AA, Zhang X, Carpenter D, Yoon S, Dumy P, BenMohamed L. Antitumor activity of a self-adjuvanting glyco-lipopeptide vaccine bearing B cell, CD4+ and CD8+ T cell epitopes. Cancer Immunol Immunother. 2009 Feb; 58(2):187-200. PMID: 18584174.
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    77. Zhang X, Issagholian A, Berg EA, Fishman JB, Nesburn AB, BenMohamed L. Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection. J Virol. 2005 Dec; 79(24):15289-301. PMID: 16306600; PMCID: PMC1316035.
    78. Peng W, Henderson G, Inman M, BenMohamed L, Perng GC, Wechsler SL, Jones C. The locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice. J Virol. 2005 May; 79(10):6162-71. PMID: 15858001; PMCID: PMC1091686.
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    80. Zhu X, Ramos TV, Gras-Masse H, Kaplan BE, BenMohamed L. Lipopeptide epitopes extended by an Nepsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Toll-like receptor-2 pathway and trigger a Th1-dependent protective immunity. Eur J Immunol. 2004 Nov; 34(11):3102-14. PMID: 15368273.
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    82. Lo-Man R, Vichier-Guerre S, Perraut R, Dériaud E, Huteau V, BenMohamed L, Diop OM, Livingston PO, Bay S, Leclerc C. A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates. Cancer Res. 2004 Jul 15; 64(14):4987-94. PMID: 15256473.
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    83. Vichier-Guerre S, Lo-Man R, BenMohamed L, Dériaud E, Kovats S, Leclerc C, Bay S. Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: a potential anti cancer vaccine for human use. J Pept Res. 2003 Sep; 62(3):117-24. PMID: 12895273.
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    84. BenMohamed L, Bertrand G, McNamara CD, Gras-Masse H, Hammer J, Wechsler SL, Nesburn AB. Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity. J Virol. 2003 Sep; 77(17):9463-73. PMID: 12915561; PMCID: PMC187395.
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    87. BenMohamed L, Wechsler SL, Nesburn AB. Lipopeptide vaccines--yesterday, today, and tomorrow. Lancet Infect Dis. 2002 Jul; 2(7):425-31. PMID: 12127354.
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    88. BenMohamed L, Krishnan R, Auge C, Primus JF, Diamond DJ. Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses. Immunology. 2002 May; 106(1):113-21. PMID: 11972639; PMCID: PMC1782698.
    89. Brahimi K, Badell E, Sauzet JP, BenMohamed L, Daubersies P, Guérin-Marchand C, Snounou G, Druilhe P. Human antibodies against Plasmodium falciparum liver-stage antigen 3 cross-react with Plasmodium yoelii preerythrocytic-stage epitopes and inhibit sporozoite invasion in vitro and in vivo. Infect Immun. 2001 Jun; 69(6):3845-52. PMID: 11349050; PMCID: PMC98406.
    90. Daubersies P, Thomas AW, Millet P, Brahimi K, Langermans JA, Ollomo B, BenMohamed L, Slierendregt B, Eling W, Van Belkum A, Dubreuil G, Meis JF, Guérin-Marchand C, Cayphas S, Cohen J, Gras-Masse H, Druilhe P, Mohamed LB. Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3. Nat Med. 2000 Nov; 6(11):1258-63. PMID: 11062538.
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    91. BenMohamed L, Krishnan R, Longmate J, Auge C, Low L, Primus J, Diamond DJ. Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: dependence on HLA class II restricted T(H) response. Hum Immunol. 2000 Aug; 61(8):764-79. PMID: 10980387.
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    92. Benmohamed L, Thomas A, Bossus M, Brahimi K, Wubben J, Gras-Masse H, Druilhe P. High immunogenicity in chimpanzees of peptides and lipopeptides derived from four new Plasmodium falciparum pre-erythrocytic molecules. Vaccine. 2000 Jun 15; 18(25):2843-55. PMID: 10812228.
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    93. BenMohamed L, Gras-Masse H, Tartar A, Daubersies P, Brahimi K, Bossus M, Thomas A, Druilhe P. Lipopeptide immunization without adjuvant induces potent and long-lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees. Eur J Immunol. 1997 May; 27(5):1242-53. PMID: 9174617.
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    94. Bossus M, BenMohamed L, Londono A, Barbier B, Tartar A, Druilhe P, Gras-Masse H, Mohammed L. Improved detection of human antibodies to a Plasmodium antigen using a peptide modified with Aib residues. J Pept Sci. 1997 Jan-Feb; 3(1):47-53. PMID: 9230470.
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    95. Bottius E, BenMohamed L, Brahimi K, Gras H, Lepers JP, Raharimalala L, Aikawa M, Meis J, Slierendregt B, Tartar A, Thomas A, Druilhe P. A novel Plasmodium falciparum sporozoite and liver stage antigen (SALSA) defines major B, T helper, and CTL epitopes. J Immunol. 1996 Apr 15; 156(8):2874-84. PMID: 8609407.
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    96. Fidock DA, Gras-Masse H, Lepers JP, Brahimi K, Benmohamed L, Mellouk S, Guerin-Marchand C, Londono A, Raharimalala L, Meis JF. Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants. J Immunol. 1994 Jul 01; 153(1):190-204. PMID: 7515922.
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