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Dynamics of Spike-Specific Neutralizing Antibodies Across Five-Year Emerging SARS-CoV-2 Variants of Concern Reveal Conserved Epitopes that Protect Against Severe COVID-19. bioRxiv. 2024 Sep 25.
Zayou L, Prakash S, Vahed H, Dhanushkodi NR, Quadiri A, Belmouden A, Lemkhente Z, Chentoufi A, Gil D, Ulmer JB, BenMohamed L. PMID: 39386567; PMCID: PMC11463540.
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PubMed Mentions:
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Therapeutic prime/pull vaccination of HSV-2-infected guinea pigs with the ribonucleotide reductase 2 (RR2) protein and CXCL11 chemokine boosts antiviral local tissue-resident and effector memory CD4+ and CD8+ T cells and protects against recurrent genital herpes. J Virol. 2024 May 14; 98(5):e0159623.
Quadiri A, Prakash S, Dhanushkodi NR, Singer M, Zayou L, Shaik AM, Sun M, Suzer B, Lau LSL, Chilukurri A, Vahed H, Schaefer H, BenMohamed L. PMID: 38587378; PMCID: PMC11092353.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCellsPHPublic Health
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High frequencies of alpha common cold coronavirus/SARS-CoV-2 cross-reactive functional CD4+ and CD8+ memory T cells are associated with protection from symptomatic and fatal SARS-CoV-2 infections in unvaccinated COVID-19 patients. Front Immunol. 2024; 15:1343716.
Coulon PG, Prakash S, Dhanushkodi NR, Srivastava R, Zayou L, Tifrea DF, Edwards RA, Figueroa CJ, Schubl SD, Hsieh L, Nesburn AB, Kuppermann BD, Bahraoui E, Vahed H, Gil D, Jones TM, Ulmer JB, BenMohamed L. PMID: 38605956; PMCID: PMC11007208.
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PubMed Mentions: Fields:
Translation:
HumansCells
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A Broad-Spectrum Multi-Antigen mRNA/LNP-Based Pan-Coronavirus Vaccine Induced Potent Cross-Protective Immunity Against Infection and Disease Caused by Highly Pathogenic and Heavily Spike-Mutated SARS-CoV-2 Variants of Concern in the Syrian Hamster Model. bioRxiv. 2024 Feb 15.
Prakash S, Dhanushkodi NR, Singer M, Quadiri A, Zayou L, Vahed H, Coulon PG, Ibraim IC, Tafoya C, Hitchcock L, Landucci G, Forthal DN, El Babsiri A, Tifrea DF, Figueroa CJ, Nesburn AB, Kuppermann BD, Gil D, Jones TM, Ulmer JB, BenMohamed L. PMID: 38405942; PMCID: PMC10888826.
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Antiviral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models. J Immunol. 2024 Feb 15; 212(4):576-585.
Dhanushkodi NR, Prakash S, Quadiri A, Zayou L, Srivastava R, Shaik AM, Suzer B, Ibraim IC, Landucci G, Tifrea DF, Singer M, Jamal L, Edwards RA, Vahed H, Brown L, BenMohamed L. PMID: 38180084.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Cross-protection induced by highly conserved human B, CD4+, and CD8+ T-cell epitopes-based vaccine against severe infection, disease, and death caused by multiple SARS-CoV-2 variants of concern. Front Immunol. 2024; 15:1328905.
Prakash S, Dhanushkodi NR, Zayou L, Ibraim IC, Quadiri A, Coulon PG, Tifrea DF, Suzer B, Shaik AM, Chilukuri A, Edwards RA, Singer M, Vahed H, Nesburn AB, Kuppermann BD, Ulmer JB, Gil D, Jones TM, BenMohamed L. PMID: 38318166; PMCID: PMC10839970.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the frequency and the function of lung-resident memory CD4+ and CD8+ T cells and enhanced protection against COVID-19-like symptoms and death caused by SARS-CoV-2 infection. J Virol. 2023 Dec 21; 97(12):e0109623.
Zayou L, Prakash S, Dhanushkodi NR, Quadiri A, Ibraim IC, Singer M, Salem A, Shaik AM, Suzer B, Chilukuri A, Tran J, Nguyen PC, Sun M, Hormi-Carver KK, Belmouden A, Vahed H, Gil D, Ulmer JB, BenMohamed L. PMID: 38038432; PMCID: PMC10734477.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) Protein and CXCL11 Chemokine Boosts Antiviral Local Tissue-Resident and Effector Memory CD4+ and CD8+ T Cells and Protects Against Recurrent Genital Herpes. bioRxiv. 2023 Aug 09.
Quadiri A, Prakash S, Dhanushkodi NR, Singer M, Zayou L, Shaik AM, Sun M, Suzer B, Lau L, Chilukurri A, Vahed H, Schaefer H, BenMohamed L. PMID: 37609157; PMCID: PMC10441333.
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PubMed Mentions:
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Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa. J Immunol. 2023 07 01; 211(1):118-129.
Dhanushkodi NR, Prakash S, Quadiri A, Zayou L, Srivastava R, Tran J, Dang V, Shaik AM, Chilukurri A, Suzer B, Vera P, Sun M, Nguyen P, Lee A, Salem A, Loi J, Singer M, Nakayama T, Vahed H, Nesburn AB, BenMohamed L. PMID: 37222480; PMCID: PMC10330291.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Cross-Protection Induced by Highly Conserved Human B, CD4+, and CD8+ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern. bioRxiv. 2023 May 24.
Prakash S, Dhanushkodi NR, Zayou L, Ibraim IC, Quadiri A, Coulon PG, Tifrea DF, Suzler B, Amin M, Chilukuri A, Edwards RA, Vahed H, Nesburn AB, Kuppermann BD, Ulmer JB, Gil D, Jones TM, BenMohamed L. PMID: 37292861; PMCID: PMC10245830.
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PubMed Mentions:
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High Frequencies of Antiviral Effector Memory TEM Cells and Memory B Cells Mobilized into Herpes Infected Vaginal Mucosa Associated With Protection Against Genital Herpes. bioRxiv. 2023 May 24.
Dhanushkodi NR, Prakash S, Quadiri A, Zayou L, Singer M, Takashi N, Vahed H, BenMohamed L. PMID: 37292784; PMCID: PMC10245907.
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PubMed Mentions:
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High Frequencies of Phenotypically and Functionally Senescent and Exhausted CD56+CD57+PD-1+ Natural Killer Cells, SARS-CoV-2-Specific Memory CD4+ and CD8+ T cells Associated with Severe Disease in Unvaccinated COVID-19 Patients. bioRxiv. 2022 Jul 27.
Srivastava R, Dhanushkodi N, Prakash S, Coulon PG, Vahed H, Zayou L, Quadiri A, BenMohamed L. PMID: 35923316; PMCID: PMC9347283.
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PubMed Mentions:
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SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions. Viruses. 2022 05 08; 14(5).
Planès R, Bert JB, Tairi S, BenMohamed L, Bahraoui E. PMID: 35632741; PMCID: PMC9146335.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Combinatorial Herpes Simplex Vaccine Strategies: From Bedside to Bench and Back. Front Immunol. 2022; 13:849515.
Chentoufi AA, Dhanushkodi NR, Srivastava R, Prakash S, Coulon PA, Zayou L, Vahed H, Chentoufi HA, Hormi-Carver KK, BenMohamed L. PMID: 35547736; PMCID: PMC9082490.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Antiviral CD19+CD27+ Memory B Cells Are Associated with Protection from Recurrent Asymptomatic Ocular Herpesvirus Infection. J Virol. 2022 03 09; 96(5):e0205721.
Dhanushkodi NR, Prakash S, Srivastava R, Coulon PA, Arellano D, Kapadia RV, Fahim R, Suzer B, Jamal L, Vahed H, BenMohamed L. PMID: 34985998; PMCID: PMC8906405.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Healing of Ocular Herpetic Disease Following Treatment With an Engineered FGF-1 Is Associated With Increased Corneal Anti-Inflammatory M2 Macrophages. Front Immunol. 2021; 12:673763.
Dhanushkodi NR, Srivastava R, Coulon PA, Prakash S, Roy S, Bagnol D, David ED, BenMohamed L. PMID: 34054858; PMCID: PMC8158292.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Genome-Wide B Cell, CD4+, and CD8+ T Cell Epitopes That Are Highly Conserved between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Targets for Preemptive Pan-Coronavirus Vaccines. J Immunol. 2021 06 01; 206(11):2566-2582.
Prakash S, Srivastava R, Coulon PG, Dhanushkodi NR, Chentoufi AA, Tifrea DF, Edwards RA, Figueroa CJ, Schubl SD, Hsieh L, Buchmeier MJ, Bouziane M, Nesburn AB, Kuppermann BD, BenMohamed L. PMID: 33911008; PMCID: PMC8722450.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Genome-Wide Asymptomatic B-Cell, CD4 + and CD8 + T-Cell Epitopes, that are Highly Conserved Between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Immune Targets for Pre-Emptive Pan-Coronavirus Vaccines. bioRxiv. 2020 Sep 28.
Prakash S, Srivastava R, Coulon PG, Dhanushkodi NR, Chentoufi AA, Tifrea DF, Edwards RA, Figueroa CJ, Schubl SD, Hsieh L, Buchmeier MJ, Bouziane M, Nesburn AB, Kuppermann BD, BenMohamed L. PMID: 33024971; PMCID: PMC7536874.
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Unique molecular signatures of antiviral memory CD8+ T cells associated with asymptomatic recurrent ocular herpes. Sci Rep. 2020 08 14; 10(1):13843.
Prakash S, Roy S, Srivastava R, Coulon PG, Dhanushkodi NR, Vahed H, Jankeel A, Geertsema R, Amezquita C, Nguyen L, Messaoudi I, Burkhardt AM, BenMohamed L. PMID: 32796943; PMCID: PMC7427992.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Upregulation of Multiple CD8+ T Cell Exhaustion Pathways Is Associated with Recurrent Ocular Herpes Simplex Virus Type 1 Infection. J Immunol. 2020 07 15; 205(2):454-468.
Coulon PG, Roy S, Prakash S, Srivastava R, Dhanushkodi N, Salazar S, Amezquita C, Nguyen L, Vahed H, Nguyen AM, Warsi WR, Ye C, Carlos-Cruz EA, Mai UT, BenMohamed L. PMID: 32540992; PMCID: PMC7343593.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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High Frequency of Gamma Interferon-Producing PLZFloRORγtlo Invariant Natural Killer 1 Cells Infiltrating Herpes Simplex Virus 1-Infected Corneas Is Associated with Asymptomatic Ocular Herpesvirus Infection. J Virol. 2020 04 16; 94(9).
Dhanushkodi NR, Srivastava R, Prakash S, Roy S, Coulon PA, Vahed H, Nguyen AM, Salazar S, Nguyen L, Amezquita C, Ye C, Nguyen V, BenMohamed L. PMID: 32102882; PMCID: PMC7163123.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall Multifunctional Effector Memory CD4+ TEM Cells in Asymptomatic Individuals and Protect from Ocular Herpes Infection and Disease in "Humanized" HLA-DR Transgenic Mice. J Virol. 2020 03 17; 94(7).
Srivastava R, Coulon PA, Prakash S, Dhanushkodi NR, Roy S, Nguyen AM, Alomari NI, Mai UT, Amezquita C, Ye C, Maillère B, BenMohamed L. PMID: 31915285; PMCID: PMC7081904.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Trimeric heptad repeat synthetic peptides HR1 and HR2 efficiently inhibit HIV-1 entry. Biosci Rep. 2019 09 30; 39(9).
Mzoughi O, Teixido M, Planès R, Serrero M, Hamimed I, Zurita E, Moreno M, Granados G, Lakhdar-Ghazal F, BenMohamed L, Giralt E, Bahraoui E. PMID: 31477581; PMCID: PMC6757187.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Blockade of PD-1 and LAG-3 Immune Checkpoints Combined with Vaccination Restores the Function of Antiviral Tissue-Resident CD8+ TRM Cells and Reduces Ocular Herpes Simplex Infection and Disease in HLA Transgenic Rabbits. J Virol. 2019 09 15; 93(18).
Roy S, Coulon PG, Prakash S, Srivastava R, Geertsema R, Dhanushkodi N, Lam C, Nguyen V, Gorospe E, Nguyen AM, Salazar S, Alomari NI, Warsi WR, BenMohamed L. PMID: 31217250; PMCID: PMC6714801.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease. Front Immunol. 2019; 10:1631.
Coulon PG, Dhanushkodi N, Prakash S, Srivastava R, Roy S, Alomari NI, Nguyen AM, Warsi WR, Ye C, Carlos-Cruz EA, Mai UT, Cruel AC, Ekmekciyan KM, Pearlman E, BenMohamed L. PMID: 31367214; PMCID: PMC6644090.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Author Correction: The wide utility of rabbits as models of human diseases. Exp Mol Med. 2019 Jul 04; 51(7):1.
Esteves PJ, Abrantes J, Baldauf HM, BenMohamed L, Chen Y, Christensen N, González-Gallego J, Giacani L, Hu J, Kaplan G, Keppler OT, Knight KL, Kong XP, Lanning DK, Le Pendu J, de Matos AL, Liu J, Liu S, Lopes AM, Lu S, Lukehart S, Manabe YC, Neves F, McFadden G, Pan R, Peng X, de Sousa-Pereira P, Pinheiro A, Rahman M, Ruvoën-Clouet N, Subbian S, Tuñón MJ, van der Loo W, Vaine M, Via LE, Wang S, Mage R. PMID: 31270317; PMCID: PMC6802666.
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PubMed Mentions:
7 Fields:
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Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4+ and CD8+ TRM Cells Associated with Protection against Recurrent Genital Herpes. J Virol. 2019 05 01; 93(9).
Srivastava R, Roy S, Coulon PG, Vahed H, Prakash S, Dhanushkodi N, Kim GJ, Fouladi MA, Campo J, Teng AA, Liang X, Schaefer H, BenMohamed L. PMID: 30787156; PMCID: PMC6475797.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Unique Type I Interferon, Expansion/Survival Cytokines, and JAK/STAT Gene Signatures of Multifunctional Herpes Simplex Virus-Specific Effector Memory CD8+ TEM Cells Are Associated with Asymptomatic Herpes in Humans. J Virol. 2019 02 15; 93(4).
Vahed H, Agrawal A, Srivastava R, Prakash S, Coulon PA, Roy S, BenMohamed L. PMID: 30487281; PMCID: PMC6364001.
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PubMed Mentions:
13 Fields:
Translation:
HumansCellsPHPublic Health
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Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8+ T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease. Front Immunol. 2018; 9:2922.
Roy S, Coulon PG, Srivastava R, Vahed H, Kim GJ, Walia SS, Yamada T, Fouladi MA, Ly VT, BenMohamed L. PMID: 30619285; PMCID: PMC6304367.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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HIV-1 Envelope Glycoproteins Induce the Production of TNF-α and IL-10 in Human Monocytes by Activating Calcium Pathway. Sci Rep. 2018 11 21; 8(1):17215.
Planès R, Serrero M, Leghmari K, BenMohamed L, Bahraoui E. PMID: 30464243; PMCID: PMC6249280.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Phenotypic and Functional Signatures of Herpes Simplex Virus-Specific Effector Memory CD73+CD45RAhighCCR7lowCD8+ TEMRA and CD73+CD45RAlowCCR7lowCD8+ TEM Cells Are Associated with Asymptomatic Ocular Herpes. J Immunol. 2018 10 15; 201(8):2315-2330.
Srivastava R, Coulon PG, Roy S, Chilukuri S, Garg S, BenMohamed L. PMID: 30201808; PMCID: PMC6195422.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Human Asymptomatic Epitope Peptide/CXCL10-Based Prime/Pull Vaccine Induces Herpes Simplex Virus-Specific Gamma Interferon-Positive CD107+ CD8+ T Cells That Infiltrate the Corneas and Trigeminal Ganglia of Humanized HLA Transgenic Rabbits and Protect against Ocular Herpes Challenge. J Virol. 2018 08 15; 92(16).
Khan AA, Srivastava R, Vahed H, Roy S, Walia SS, Kim GJ, Fouladi MA, Yamada T, Ly VT, Lam C, Lou A, Nguyen V, Boldbaatar U, Geertsema R, Fraser NW, BenMohamed L. PMID: 29899087; PMCID: PMC6069188.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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The wide utility of rabbits as models of human diseases. Exp Mol Med. 2018 05 22; 50(5):1-10.
Esteves PJ, Abrantes J, Baldauf HM, BenMohamed L, Chen Y, Christensen N, González-Gallego J, Giacani L, Hu J, Kaplan G, Keppler OT, Knight KL, Kong XP, Lanning DK, Le Pendu J, de Matos AL, Liu J, Liu S, Lopes AM, Lu S, Lukehart S, Manabe YC, Neves F, McFadden G, Pan R, Peng X, de Sousa-Pereira P, Pinheiro A, Rahman M, Ruvoën-Clouet N, Subbian S, Tuñón MJ, van der Loo W, Vaine M, Via LE, Wang S, Mage R. PMID: 29789565; PMCID: PMC5964082.
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PubMed Mentions:
69 Fields:
Translation:
HumansAnimals
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Laser Adjuvant-Assisted Peptide Vaccine Promotes Skin Mobilization of Dendritic Cells and Enhances Protective CD8+ TEM and TRM Cell Responses against Herpesvirus Infection and Disease. J Virol. 2018 04 15; 92(8).
Lopes PP, Todorov G, Pham TT, Nesburn AB, Bahraoui E, BenMohamed L. PMID: 29437976; PMCID: PMC5874417.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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CXCL17 Chemokine-Dependent Mobilization of CXCR8+CD8+ Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes. J Immunol. 2018 04 15; 200(8):2915-2926.
Srivastava R, Hernández-Ruiz M, Khan AA, Fouladi MA, Kim GJ, Ly VT, Yamada T, Lam C, Sarain SAB, Boldbaatar U, Zlotnik A, Bahraoui E, BenMohamed L. PMID: 29549178; PMCID: PMC5893430.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8+ TEM and CD8+ TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease. J Virol. 2017 07 15; 91(14).
Srivastava R, Khan AA, Chilukuri S, Syed SA, Tran TT, Furness J, Bahraoui E, BenMohamed L. PMID: 28468883; PMCID: PMC5487556.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Bolstering the Number and Function of HSV-1-Specific CD8+ Effector Memory T Cells and Tissue-Resident Memory T Cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease. J Immunol. 2017 07 01; 199(1):186-203.
Khan AA, Srivastava R, Chentoufi AA, Kritzer E, Chilukuri S, Garg S, Yu DC, Vahed H, Huang L, Syed SA, Furness JN, Tran TT, Anthony NB, McLaren CE, Sidney J, Sette A, Noelle RJ, BenMohamed L. PMID: 28539429; PMCID: PMC5515716.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Airway epithelial cells enhance the immunogenicity of human myeloid dendritic cells under steady state. Clin Exp Immunol. 2017 09; 189(3):279-289.
Agrawal S, Srivastava R, Rahmatpanah F, Madiraju C, BenMohamed L, Agrawal A. PMID: 28470729; PMCID: PMC5543474.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy. Inflammation. 2017 Feb; 40(1):21-41.
Nalbandian A, Khan AA, Srivastava R, Llewellyn KJ, Tan B, Shukr N, Fazli Y, Kimonis VE, BenMohamed L. PMID: 27730320; PMCID: PMC5800525.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44high CD62Llow CD8+ TEM Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpesvirus Infection. J Virol. 2017 Jan 15; 91(2).
Srivastava R, Khan AA, Garg S, Syed SA, Furness JN, Vahed H, Pham T, Yu HT, Nesburn AB, BenMohamed L. PMID: 27847359; PMCID: PMC5215341.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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A Tribute to Professor Steven L. Wechsler (1948-2016): The Man and the Scientist. Curr Eye Res. 2017 01; 42(1):161-162.
Nesburn AB, BenMohamed L. PMID: 27911113; PMCID: PMC6235443.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes. J Virol. 2016 07 01; 90(13):5886-5898.
Planès R, Ben Haij N, Leghmari K, Serrero M, BenMohamed L, Bahraoui E. PMID: 27053552; PMCID: PMC4907244.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits. J Virol. 2016 Apr; 90(8):3913-3928.
Srivastava R, Dervillez X, Khan AA, Chentoufi AA, Chilukuri S, Shukr N, Fazli Y, Ong NN, Afifi RE, Osorio N, Geertsema R, Nesburn AB, Wechsler SL, BenMohamed L. PMID: 26842468; PMCID: PMC4810530.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis. Cornea. 2016 Jan; 35(1):81-8.
Jester JV, Morishige N, BenMohamed L, Brown DJ, Osorio N, Hsiang C, Perng GC, Jones C, Wechsler SL. PMID: 26555580; PMCID: PMC4674384.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Prior Corneal Scarification and Injection of Immune Serum are Not Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice. Curr Eye Res. 2016 06; 41(6):747-56.
BenMohamed L, Osorio N, Khan AA, Srivastava R, Huang L, Krochmal JJ, Garcia JM, Simpson JL, Wechsler SL. PMID: 26398722; PMCID: PMC5349863.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-Based Anticancer Vaccine. ACS Chem Biol. 2015 Oct 16; 10(10):2364-72.
Yin Z, Chowdhury S, McKay C, Baniel C, Wright WS, Bentley P, Kaczanowska K, Gildersleeve JC, Finn MG, BenMohamed L, Huang X. PMID: 26262839; PMCID: PMC4725323.
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PubMed Mentions:
32 Fields:
Translation:
Animals
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A Fine Balance of Dietary Lipids Improves Pathology of a Murine Model of VCP-Associated Multisystem Proteinopathy. PLoS One. 2015; 10(7):e0131995.
Llewellyn KJ, Walker N, Nguyen C, Tan B, BenMohamed L, Kimonis VE, Nalbandian A. PMID: 26134519; PMCID: PMC4489713.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Therapeutic immunization with a mixture of herpes simplex virus 1 glycoprotein D-derived “asymptomatic” human CD8+ T-cell epitopes decreases spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low frequency of local PD-1+ TIM-3+ CD8+ exhausted T cells. J Virol. 2015 Jul; 89(13):6619-32.
Khan AA, Srivastava R, Chentoufi AA, Geertsema R, Thai NT, Dasgupta G, Osorio N, Kalantari M, Nesburn AB, Wechsler SL, BenMohamed L. PMID: 25878105; PMCID: PMC4468472.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation of NF-κB Pathway. PLoS One. 2015; 10(6):e0129425.
Ben Haij N, Planès R, Leghmari K, Serrero M, Delobel P, Izopet J, BenMohamed L, Bahraoui E. PMID: 26090662; PMCID: PMC4474861.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT). J Neurovirol. 2015 Oct; 21(5):568-75.
Carpenter D, Hsiang C, Jiang X, Osorio N, BenMohamed L, Jones C, Wechsler SL. PMID: 26071090; PMCID: PMC5349860.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Increased neurovirulence and reactivation of the herpes simplex virus type 1 latency-associated transcript (LAT)-negative mutant dLAT2903 with a disrupted LAT miR-H2. J Neurovirol. 2016 Feb; 22(1):38-49.
Jiang X, Brown D, Osorio N, Hsiang C, BenMohamed L, Wechsler SL. PMID: 26069184; PMCID: PMC4676951.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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A Herpes Simplex Virus Type 1 Human Asymptomatic CD8+ T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a "Humanized" HLA Transgenic Rabbit Model. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):4013-28.
Srivastava R, Khan AA, Huang J, Nesburn AB, Wechsler SL, BenMohamed L. PMID: 26098469; PMCID: PMC4477261.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation. J Neurovirol. 2015 Oct; 21(5):508-17.
BenMohamed L, Osorio N, Srivastava R, Khan AA, Simpson JL, Wechsler SL. PMID: 26002839; PMCID: PMC4618093.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. Curr Eye Res. 2016; 41(3):284-91.
Perng GC, Osorio N, Jiang X, Geertsema R, Hsiang C, Brown D, BenMohamed L, Wechsler SL. PMID: 25859798; PMCID: PMC5349859.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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A herpes simplex virus type 1 mutant disrupted for microRNA H2 with increased neurovirulence and rate of reactivation. J Neurovirol. 2015 Apr; 21(2):199-209.
Jiang X, Brown D, Osorio N, Hsiang C, Li L, Chan L, BenMohamed L, Wechsler SL. PMID: 25645379; PMCID: PMC4375036.
View in:
PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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HLA-A02:01-restricted epitopes identified from the herpes simplex virus tegument protein VP11/12 preferentially recall polyfunctional effector memory CD8+ T cells from seropositive asymptomatic individuals and protect humanized HLA-A*02:01 transgenic mice against ocular herpes. J Immunol. 2015 Mar 01; 194(5):2232-48.
Srivastava R, Khan AA, Spencer D, Vahed H, Lopes PP, Thai NT, Wang C, Pham TT, Huang J, Scarfone VM, Nesburn AB, Wechsler SL, BenMohamed L. PMID: 25617474; PMCID: PMC4340763.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Phenotypic and functional characterization of herpes simplex virus glycoprotein B epitope-specific effector and memory CD8+ T cells from symptomatic and asymptomatic individuals with ocular herpes. J Virol. 2015 Apr; 89(7):3776-92.
Khan AA, Srivastava R, Spencer D, Garg S, Fremgen D, Vahed H, Lopes PP, Pham TT, Hewett C, Kuang J, Ong N, Huang L, Scarfone VM, Nesburn AB, Wechsler SL, BenMohamed L. PMID: 25609800; PMCID: PMC4403403.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease. Ocul Immunol Inflamm. 2016 Jun; 24(3):327-47.
Farid M, Agrawal A, Fremgen D, Tao J, Chuyi H, Nesburn AB, BenMohamed L. PMID: 25535823; PMCID: PMC4478284.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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The challenges and opportunities for the development of a T-cell epitope-based herpes simplex vaccine. Vaccine. 2014 Nov 28; 32(50):6733-45.
Kuo T, Wang C, Badakhshan T, Chilukuri S, BenMohamed L. PMID: 25446827; PMCID: PMC4254646.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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A cancer therapeutic vaccine based on clustered Tn-antigen mimetics induces strong antibody-mediated protective immunity. Angew Chem Int Ed Engl. 2014 Oct 27; 53(44):11917-20.
Richichi B, Thomas B, Fiore M, Bosco R, Qureshi H, Nativi C, Renaudet O, BenMohamed L. PMID: 25168881; PMCID: PMC4564297.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
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Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: implication for the development of an universal CD8+ T-cell epitope-based vaccine. Hum Immunol. 2014 Aug; 75(8):715-29.
Samandary S, Kridane-Miledi H, Sandoval JS, Choudhury Z, Langa-Vives F, Spencer D, Chentoufi AA, Lemonnier FA, BenMohamed L. PMID: 24798939; PMCID: PMC4119854.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. Mucosal Immunol. 2014 Nov; 7(6):1386-94.
Prakash S, Agrawal S, Vahed H, Ngyuen M, BenMohamed L, BenMohamad L, Gupta S, Agrawal A. PMID: 24759206; PMCID: PMC4205198.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCellsCTClinical Trials
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HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms. J Virol. 2014 Jun; 88(12):6672-89.
Planès R, BenMohamed L, Leghmari K, Delobel P, Izopet J, Bahraoui E. PMID: 24696476; PMCID: PMC4054384.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Asymptomatic memory CD8+ T cells: from development and regulation to consideration for human vaccines and immunotherapeutics. Hum Vaccin Immunother. 2014; 10(4):945-63.
Khan AA, Srivastava R, Lopes PP, Wang C, Pham TT, Cochrane J, Thai NT, Gutierrez L, Benmohamed L. PMID: 24499824; PMCID: PMC4896594.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes. J Immunol. 2013 Nov 15; 191(10):5124-38.
Dervillez X, Qureshi H, Chentoufi AA, Khan AA, Kritzer E, Yu DC, Diaz OR, Gottimukkala C, Kalantari M, Villacres MC, Scarfone VM, McKinney DM, Sidney J, Sette A, Nesburn AB, Wechsler SL, BenMohamed L. PMID: 24101547; PMCID: PMC4057607.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Cytokine profiling in patients with VCP-associated disease. Clin Transl Sci. 2014 Feb; 7(1):29-32.
Dec E, Rana P, Katheria V, Dec R, Khare M, Nalbandian A, Leu SY, Radom-Aizik S, Llewellyn K, BenMohamed L, Zaldivar F, Kimonis V. PMID: 24119107; PMCID: PMC4057603.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses. J Immunol. 2013 Jul 15; 191(2):583-93.
Boucherma R, Kridane-Miledi H, Bouziat R, Rasmussen M, Gatard T, Langa-Vives F, Lemercier B, Lim A, Bérard M, Benmohamed L, Buus S, Rooke R, Lemonnier FA. PMID: 23776170; PMCID: PMC4057605.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Boosting immunity to small tumor-associated carbohydrates with bacteriophage qβ capsids. ACS Chem Biol. 2013; 8(6):1253-62.
Yin Z, Comellas-Aragones M, Chowdhury S, Bentley P, Kaczanowska K, Benmohamed L, Gildersleeve JC, Finn MG, Huang X. PMID: 23505965; PMCID: PMC3735802.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Immunity to ocular and genital herpes simplex viruses infections. Clin Dev Immunol. 2012; 2012:732546.
Chentoufi AA, BenMohamed L, Van De Perre P, Ashkar AA. PMID: 23326289; PMCID: PMC3541643.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Mucosal herpes immunity and immunopathology to ocular and genital herpes simplex virus infections. Clin Dev Immunol. 2012; 2012:149135.
Chentoufi AA, Benmohamed L. PMID: 23320014; PMCID: PMC3540975.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimals
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Targeting the genital tract mucosa with a lipopeptide/recombinant adenovirus prime/boost vaccine induces potent and long-lasting CD8+ T cell immunity against herpes: importance of MyD88. J Immunol. 2012 Nov 01; 189(9):4496-509.
Zhang X, Dervillez X, Chentoufi AA, Badakhshan T, Bettahi I, Benmohamed L. PMID: 23018456; PMCID: PMC3478413.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells. Viral Immunol. 2012 Jun; 25(3):204-15.
Chentoufi AA, Dervillez X, Dasgupta G, Nguyen C, Kabbara KW, Jiang X, Nesburn AB, Wechsler SL, Benmohamed L. PMID: 22512280; PMCID: PMC3366336.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Future of an "Asymptomatic" T-cell Epitope-Based Therapeutic Herpes Simplex Vaccine. Future Virol. 2012 Apr 01; 7(4):371-378.
Dervillez X, Gottimukkala C, Kabbara KW, Nguyen C, Badakhshan T, Kim SM, Nesburn AB, Wechsler SL, Benmohamed L. PMID: 22701511; PMCID: PMC3372919.
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PubMed Mentions:
27
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Towards a rational design of an asymptomatic clinical herpes vaccine: the old, the new, and the unknown. Clin Dev Immunol. 2012; 2012:187585.
Chentoufi AA, Kritzer E, Yu DM, Nesburn AB, Benmohamed L. PMID: 22548113; PMCID: PMC3324142.
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PubMed Mentions:
38 Fields:
Translation:
HumansCellsPHPublic Health
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Immunodominant "asymptomatic" herpes simplex virus 1 and 2 protein antigens identified by probing whole-ORFome microarrays with serum antibodies from seropositive asymptomatic versus symptomatic individuals. J Virol. 2012 Apr; 86(8):4358-69.
Dasgupta G, Chentoufi AA, Kalantari M, Falatoonzadeh P, Chun S, Lim CH, Felgner PL, Davies DH, BenMohamed L. PMID: 22318137; PMCID: PMC3318627.
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PubMed Mentions:
36 Fields:
Translation:
HumansCells
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Discovery of potential diagnostic and vaccine antigens in herpes simplex virus 1 and 2 by proteome-wide antibody profiling. J Virol. 2012 Apr; 86(8):4328-39.
Kalantari-Dehaghi M, Chun S, Chentoufi AA, Pablo J, Liang L, Dasgupta G, Molina DM, Jasinskas A, Nakajima-Sasaki R, Felgner J, Hermanson G, BenMohamed L, Felgner PL, Davies DH. PMID: 22318154; PMCID: PMC3318641.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Current trends in negative immuno-synergy between two sexually transmitted infectious viruses: HIV-1 and HSV-1/2. Curr Trends Immunol. 2012; 13:51-68.
Chentoufi AA, Dervillez X, Rubbo PA, Kuo T, Zhang X, Nagot N, Tuaillon E, Van De Perre P, Nesburn AB, Benmohamed L. PMID: 23355766; PMCID: PMC3552495.
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PubMed Mentions:
11
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HIV-1 infection impairs HSV-specific CD4(+) and CD8(+) T-cell response by reducing Th1 cytokines and CCR5 ligand secretion. J Acquir Immune Defic Syndr. 2011 Sep 01; 58(1):9-17.
Rubbo PA, Tuaillon E, Nagot N, Chentoufi AA, Bolloré K, Reynes J, Vendrell JP, BenMohamed L, Van De Perre P. PMID: 21646911.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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CD11c controls herpes simplex virus 1 responses to limit virus replication during primary infection. J Virol. 2011 Oct; 85(19):9945-55.
Allen SJ, Mott KR, Chentoufi AA, BenMohamed L, Wechsler SL, Ballantyne CM, Ghiasi H. PMID: 21775452; PMCID: PMC3196403.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism. J Virol. 2011 Sep; 85(17):9127-38.
Chentoufi AA, Kritzer E, Tran MV, Dasgupta G, Lim CH, Yu DC, Afifi RE, Jiang X, Carpenter D, Osorio N, Hsiang C, Nesburn AB, Wechsler SL, BenMohamed L. PMID: 21715478; PMCID: PMC3165846.
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PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
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Of mice and not humans: how reliable are animal models for evaluation of herpes CD8(+)-T cell-epitopes-based immunotherapeutic vaccine candidates? Vaccine. 2011 Aug 11; 29(35):5824-36.
Dasgupta G, BenMohamed L. PMID: 21718746; PMCID: PMC3159167.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses. Invest Ophthalmol Vis Sci. 2011 May 17; 52(6):3321-33.
Dasgupta G, Chentoufi AA, You S, Falatoonzadeh P, Urbano LA, Akhtarmalik A, Nguyen K, Ablabutyan L, Nesburn AB, BenMohamed L. PMID: 21273544; PMCID: PMC3109031.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. J Virol. 2011 May; 85(9):4184-97.
Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H. PMID: 21307196; PMCID: PMC3126262.
View in:
PubMed Mentions:
90 Fields:
Translation:
AnimalsCells
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Interferon-γ, a valuable surrogate marker of Plasmodium falciparum pre-erythrocytic stages protective immunity. Malar J. 2011 Feb 08; 10:27.
Perlaza BL, Sauzet JP, Brahimi K, BenMohamed L, Druilhe P. PMID: 21303495; PMCID: PMC3046914.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing. J Virol. 2011 Mar; 85(5):2325-32.
Jiang X, Chentoufi AA, Hsiang C, Carpenter D, Osorio N, BenMohamed L, Fraser NW, Jones C, Wechsler SL. PMID: 21177822; PMCID: PMC3067767.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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Future viral vectors for the delivery of asymptomatic herpes epitope-based immunotherapeutic vaccines. Future Virol. 2010 Sep 01; 5(5):525-528.
Chentoufi AA, BenMohamed L. PMID: 21442030; PMCID: PMC3063648.
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PubMed Mentions:
20
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Linear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunity. PLoS One. 2010 Jun 21; 5(6):e11216.
Renaudet O, Dasgupta G, Bettahi I, Shi A, Nesburn AB, Dumy P, BenMohamed L. PMID: 20574522; PMCID: PMC2888579.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitope-based vaccines against ocular herpes. J Immunol. 2010 Mar 01; 184(5):2561-71.
Chentoufi AA, Dasgupta G, Christensen ND, Hu J, Choudhury ZS, Azeem A, Jester JV, Nesburn AB, Wechsler SL, BenMohamed L. PMID: 20124097; PMCID: PMC3752373.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Nasolacrimal duct closure modulates ocular mucosal and systemic CD4(+) T-cell responses induced following topical ocular or intranasal immunization. Clin Vaccine Immunol. 2010 Mar; 17(3):342-53.
Chentoufi AA, Dasgupta G, Nesburn AB, Bettahi I, Binder NR, Choudhury ZS, Chamberlain WD, Wechsler SL, BenMohamed L. PMID: 20089796; PMCID: PMC2837957.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCellsPHPublic Health
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Developing an asymptomatic mucosal herpes vaccine: the present and the future. Future Microbiol. 2010 Jan; 5(1):1-4.
Dasgupta G, Nesburn AB, Wechsler SL, BenMohamed L. PMID: 20020824; PMCID: PMC4512283.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Recent advances in multivalent self adjuvanting glycolipopeptide vaccine strategies against breast cancer. Arch Immunol Ther Exp (Warsz). 2009 Nov-Dec; 57(6):409-23.
Chentoufi AA, Nesburn AB, BenMohamed L. PMID: 19866342.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
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New concepts in herpes simplex virus vaccine development: notes from the battlefield. Expert Rev Vaccines. 2009 Aug; 8(8):1023-35.
Dasgupta G, Chentoufi AA, Nesburn AB, Wechsler SL, BenMohamed L. PMID: 19627185; PMCID: PMC2760836.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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The role of a glycoprotein K (gK) CD8+ T-cell epitope of herpes simplex virus on virus replication and pathogenicity. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2903-12.
Mott KR, Chentoufi AA, Carpenter D, BenMohamed L, Wechsler SL, Ghiasi H. PMID: 19168902.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCellsPHPublic Health
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A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge. Mucosal Immunol. 2009 Mar; 2(2):129-143.
Zhang X, Chentoufi AA, Dasgupta G, Nesburn AB, Wu M, Zhu X, Carpenter D, Wechsler SL, You S, BenMohamed L. PMID: 19129756; PMCID: PMC4509510.
View in:
PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
-
Level of herpes simplex virus type 1 latency correlates with severity of corneal scarring and exhaustion of CD8+ T cells in trigeminal ganglia of latently infected mice. J Virol. 2009 Mar; 83(5):2246-54.
Mott KR, Bresee CJ, Allen SJ, BenMohamed L, Wechsler SL, Ghiasi H. PMID: 19091870; PMCID: PMC2643740.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Asymptomatic human CD4+ cytotoxic T-cell epitopes identified from herpes simplex virus glycoprotein B. J Virol. 2008 Dec; 82(23):11792-802.
Chentoufi AA, Binder NR, Berka N, Durand G, Nguyen A, Bettahi I, Maillère B, BenMohamed L. PMID: 18799581; PMCID: PMC2583686.
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PubMed Mentions:
43 Fields:
Translation:
HumansCells
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Gender-dependent HLA-DR-restricted epitopes identified from herpes simplex virus type 1 glycoprotein D. Clin Vaccine Immunol. 2008 Sep; 15(9):1436-49.
Zhang X, Castelli FA, Zhu X, Wu M, Maillère B, BenMohamed L. PMID: 18667634; PMCID: PMC2546687.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Antitumor activity of a self-adjuvanting glyco-lipopeptide vaccine bearing B cell, CD4+ and CD8+ T cell epitopes. Cancer Immunol Immunother. 2009 Feb; 58(2):187-200.
Bettahi I, Dasgupta G, Renaudet O, Chentoufi AA, Zhang X, Carpenter D, Yoon S, Dumy P, BenMohamed L. PMID: 18584174; PMCID: PMC11030914.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Towards a self-adjuvanting multivalent B and T cell epitope containing synthetic glycolipopeptide cancer vaccine. ChemMedChem. 2008 May; 3(5):737-41.
Renaudet O, BenMohamed L, Dasgupta G, Bettahi I, Dumy P. PMID: 18205167.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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HLA-A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D. J Immunol. 2008 Jan 01; 180(1):426-37.
Chentoufi AA, Zhang X, Lamberth K, Dasgupta G, Bettahi I, Nguyen A, Wu M, Zhu X, Mohebbi A, Buus S, Wechsler SL, Nesburn AB, BenMohamed L. PMID: 18097044.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4643-53.
Bettahi I, Nesburn AB, Yoon S, Zhang X, Mohebbi A, Sue V, Vanderberg A, Wechsler SL, BenMohamed L. PMID: 17898288.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCellsPHPublic Health
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Stable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosis. Virology. 2007 Dec 05; 369(1):12-8.
Carpenter D, Hsiang C, Brown DJ, Jin L, Osorio N, BenMohamed L, Jones C, Wechsler SL. PMID: 17727910; PMCID: PMC2276668.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity. Microb Pathog. 2008 Feb; 44(2):98-102.
Carpenter D, Henderson G, Hsiang C, Osorio N, BenMohamed L, Jones C, Wechsler SL. PMID: 17900852; PMCID: PMC2291025.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection. J Virol. 2007 Jul; 81(14):7647-61.
Nesburn AB, Bettahi I, Dasgupta G, Chentoufi AA, Zhang X, You S, Morishige N, Wahlert AJ, Brown DJ, Jester JV, Wechsler SL, BenMohamed L. PMID: 17475646; PMCID: PMC1933381.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune system. Ocul Surf. 2006 Oct; 4(4):178-87.
Nesburn AB, Bettahi I, Zhang X, Zhu X, Chamberlain W, Afifi RE, Wechsler SL, BenMohamed L. PMID: 17146573.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsPHPublic Health
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Protective immunity to genital herpes simplex virus type 1 and type 2 provided by self-adjuvanting lipopeptides that drive dendritic cell maturation and elicit a polarized Th1 immune response. Viral Immunol. 2006; 19(2):220-36.
Bettahi I, Zhang X, Afifi RE, BenMohamed L. PMID: 16817765.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection. J Virol. 2005 Dec; 79(24):15289-301.
Zhang X, Issagholian A, Berg EA, Fishman JB, Nesburn AB, BenMohamed L. PMID: 16306600; PMCID: PMC1316035.
View in:
PubMed Mentions:
43 Fields:
Translation:
Cells
-
The locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice. J Virol. 2005 May; 79(10):6162-71.
Peng W, Henderson G, Inman M, BenMohamed L, Perng GC, Wechsler SL, Jones C. PMID: 15858001; PMCID: PMC1091686.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant. Vaccine. 2005 Jan 04; 23(7):873-83.
Nesburn AB, Ramos TV, Zhu X, Asgarzadeh H, Nguyen V, BenMohamed L. PMID: 15603887.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Lipopeptide epitopes extended by an Nepsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Toll-like receptor-2 pathway and trigger a Th1-dependent protective immunity. Eur J Immunol. 2004 Nov; 34(11):3102-14.
Zhu X, Ramos TV, Gras-Masse H, Kaplan BE, BenMohamed L. PMID: 15368273.
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AnimalsCellsPHPublic Health
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Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides. Infect Immun. 2004 Aug; 72(8):4376-84.
BenMohamed L, Thomas A, Druilhe P. PMID: 15271893; PMCID: PMC470687.
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HumansAnimalsCellsPHPublic Health
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A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates. Cancer Res. 2004 Jul 15; 64(14):4987-94.
Lo-Man R, Vichier-Guerre S, Perraut R, Dériaud E, Huteau V, BenMohamed L, Diop OM, Livingston PO, Bay S, Leclerc C. PMID: 15256473.
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HumansAnimalsCells
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Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity. J Virol. 2003 Sep; 77(17):9463-73.
BenMohamed L, Bertrand G, McNamara CD, Gras-Masse H, Hammer J, Wechsler SL, Nesburn AB. PMID: 12915561; PMCID: PMC187395.
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43 Fields:
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AnimalsCellsPHPublic Health
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Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: a potential anti cancer vaccine for human use. J Pept Res. 2003 Sep; 62(3):117-24.
Vichier-Guerre S, Lo-Man R, BenMohamed L, Dériaud E, Kovats S, Leclerc C, Bay S. PMID: 12895273.
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13 Fields:
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HumansAnimalsCells
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A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits. J Virol. 2002 Aug; 76(16):8003-10.
Perng GC, Maguen B, Jin L, Mott KR, Kurylo J, BenMohamed L, Yukht A, Osorio N, Nesburn AB, Henderson G, Inman M, Jones C, Wechsler SL. PMID: 12134005; PMCID: PMC155148.
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36 Fields:
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AnimalsCells
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Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant. Eur J Immunol. 2002 Aug; 32(8):2274-81.
BenMohamed L, Belkaid Y, Loing E, Brahimi K, Gras-Masse H, Druilhe P. PMID: 12209640.
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36 Fields:
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AnimalsCellsPHPublic Health
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Lipopeptide vaccines--yesterday, today, and tomorrow. Lancet Infect Dis. 2002 Jul; 2(7):425-31.
BenMohamed L, Wechsler SL, Nesburn AB. PMID: 12127354.
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56 Fields:
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HumansCells
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Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses. Immunology. 2002 May; 106(1):113-21.
BenMohamed L, Krishnan R, Auge C, Primus JF, Diamond DJ. PMID: 11972639; PMCID: PMC1782698.
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32 Fields:
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HumansAnimalsCellsPHPublic Health
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Human antibodies against Plasmodium falciparum liver-stage antigen 3 cross-react with Plasmodium yoelii preerythrocytic-stage epitopes and inhibit sporozoite invasion in vitro and in vivo. Infect Immun. 2001 Jun; 69(6):3845-52.
Brahimi K, Badell E, Sauzet JP, BenMohamed L, Daubersies P, Guérin-Marchand C, Snounou G, Druilhe P. PMID: 11349050; PMCID: PMC98406.
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18 Fields:
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HumansAnimalsCells
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Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3. Nat Med. 2000 Nov; 6(11):1258-63.
Daubersies P, Thomas AW, Millet P, Brahimi K, Langermans JA, Ollomo B, BenMohamed L, Slierendregt B, Eling W, Van Belkum A, Dubreuil G, Meis JF, Guérin-Marchand C, Cayphas S, Cohen J, Gras-Masse H, Druilhe P, Mohamed LB. PMID: 11062538.
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64 Fields:
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HumansAnimalsCells
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Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: dependence on HLA class II restricted T(H) response. Hum Immunol. 2000 Aug; 61(8):764-79.
BenMohamed L, Krishnan R, Longmate J, Auge C, Low L, Primus J, Diamond DJ. PMID: 10980387.
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25 Fields:
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AnimalsCells
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High immunogenicity in chimpanzees of peptides and lipopeptides derived from four new Plasmodium falciparum pre-erythrocytic molecules. Vaccine. 2000 Jun 15; 18(25):2843-55.
Benmohamed L, Thomas A, Bossus M, Brahimi K, Wubben J, Gras-Masse H, Druilhe P. PMID: 10812228.
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23 Fields:
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AnimalsCells
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Lipopeptide immunization without adjuvant induces potent and long-lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees. Eur J Immunol. 1997 May; 27(5):1242-53.
BenMohamed L, Gras-Masse H, Tartar A, Daubersies P, Brahimi K, Bossus M, Thomas A, Druilhe P. PMID: 9174617.
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41 Fields:
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AnimalsCells
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Improved detection of human antibodies to a Plasmodium antigen using a peptide modified with Aib residues. J Pept Sci. 1997 Jan-Feb; 3(1):47-53.
Bossus M, BenMohamed L, Londono A, Barbier B, Tartar A, Druilhe P, Gras-Masse H, Mohammed L. PMID: 9230470.
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4 Fields:
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HumansAnimalsCells
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A novel Plasmodium falciparum sporozoite and liver stage antigen (SALSA) defines major B, T helper, and CTL epitopes. J Immunol. 1996 Apr 15; 156(8):2874-84.
Bottius E, BenMohamed L, Brahimi K, Gras H, Lepers JP, Raharimalala L, Aikawa M, Meis J, Slierendregt B, Tartar A, Thomas A, Druilhe P. PMID: 8609407.
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24 Fields:
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HumansAnimalsCells
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Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants. J Immunol. 1994 Jul 01; 153(1):190-204.
Fidock DA, Gras-Masse H, Lepers JP, Brahimi K, Benmohamed L, Mellouk S, Guerin-Marchand C, Londono A, Raharimalala L, Meis JF, et al. PMID: 7515922.
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60 Fields:
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HumansAnimalsCells