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Mclaren, Christine Ellen

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentEpidemiology
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-4007
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    Collapse Research 
    Collapse Research Activities and Funding
    Genetic Modifiers of Iron Status in Hemochromatosis HFE C282Y Homozygotes
    NIH/NIDDK R24DK099846Sep 1, 2014 - Jun 30, 2017
    Role: Principal Investigator
    Genetic Modifiers of Iron Status in Hemochromatosis HFE C282Y Homozygotes
    NIH/NIDDK R24DK093433Sep 15, 2011 - Aug 31, 2014
    Role: Principal Investigator
    Iron Status: A Pathway Analysis in Multiple Ethnicities
    NIH/NHLBI R01HL083328Aug 14, 2006 - Jul 31, 2012
    Role: Principal Investigator
    IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSIS STUDY
    NIH/NHLBI N01HC005190Jan 31, 2000 - Jan 31, 2005
    Role: Principal Investigator
    STATISTICAL BASIS FOR HEMOCHROMATOSIS SCREENING
    NIH/NHLBI R15HL058203Jul 15, 1997 - Jun 30, 2000
    Role: Principal Investigator
    GENERALIZED CHI-SQUARED TEST FOR COMPARING DISTRIBUTIONS
    NIH/FIC F06TW002117Nov 27, 1995
    Role: Principal Investigator
    SEQUENTIAL ANALYSIS OF HEMATOLOGIC MEASUREMENTS
    NIH/NHLBI R15HL048349Jun 1, 1992 - May 31, 1995
    Role: Principal Investigator
    MIXTURES OF RED BLOOD CELL VOLUME DISTRIBUTIONS
    NIH/NHLBI R15HL042681Apr 15, 1989 - Mar 31, 1992
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Brissot P, Pietrangelo A, Adams PC, de Graaff B, McLaren C, Loréal O. Haemochromatosis. Nat Rev Dis Primers. 2018 Apr 05; 4:18016. PMID: 29620054.
      View in: PubMed
    2. Lam JH, O'Sullivan TD, Park TS, Choi JH, Warren RV, Chen WP, McLaren C, Cancio LC, Batchinsky AI, Tromberg BJ. Non-invasive Dual-Channel Broadband Diffuse Optical Spectroscopy of Massive Hemorrhage and Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in Swine. Mil Med. 2018 Mar 01; 183(suppl_1):150-156. PMID: 29635570.
      View in: PubMed
    3. Khan AA, Srivastava R, Chentoufi AA, Kritzer E, Chilukuri S, Garg S, Yu DC, Vahed H, Huang L, Syed SA, Furness JN, Tran TT, Anthony NB, McLaren C, Sidney J, Sette A, Noelle RJ, BenMohamed L. Bolstering the Number and Function of HSV-1-Specific CD8+ Effector Memory T Cells and Tissue-Resident Memory T Cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease. J Immunol. 2017 07 01; 199(1):186-203. PMID: 28539429.
      View in: PubMed
    4. McLaren C, Chen WP, O'Sullivan TD, Gillen DL, Su MY, Chen JH, Tromberg BJ. Sample size and power determination when limited preliminary information is available. BMC Med Res Methodol. 2017 Apr 26; 17(1):75. PMID: 28446127.
      View in: PubMed
    5. Warne CD, Zaloumis SG, Bertalli NA, Delatycki MB, Nicoll AJ, McLaren C, Hopper JL, Giles GG, Anderson GJ, Olynyk JK, Powell LW, Allen KJ, Gurrin LC. HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women. J Gastroenterol Hepatol. 2017 Apr; 32(4):797-802. PMID: 27784128.
      View in: PubMed
    6. Aminololama-Shakeri S, Flowers CI, McLaren C, Wisner DJ, de Guzman J, Campbell JE, Bassett LW, Ojeda-Fournier H, Gerlach K, Hargreaves J, Elson SL, Retallack H, Joe BN, Feig SA, Wells CJ. Can Radiologists Predict the Presence of Ductal Carcinoma In Situ and Invasive Breast Cancer? AJR Am J Roentgenol. 2017 Apr; 208(4):933-939. PMID: 28199152.
      View in: PubMed
    7. McLaren GD, Barton JC, Ramm GA, Emond MJ, Subramaniam VN, Phatak PD, Adams PC, Powell LW, Gurrin LC, Anderson GJ, McLaren C. Reply. Hepatology. 2017 03; 65(3):1072-1073. PMID: 28010035.
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    8. Barton JC, Chen WP, Emond MJ, Phatak PD, Subramaniam VN, Adams PC, Gurrin LC, Anderson GJ, Ramm GA, Powell LW, Allen KJ, Phillips JD, Parker CJ, McLaren GD, McLaren C. GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes. Blood Cells Mol Dis. 2017 03; 63:15-20. PMID: 27936396.
      View in: PubMed
    9. Huang JY, Samarasena JB, Tsujino T, Lee J, Hu KQ, McLaren C, Chen WP, Chang KJ. EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study. Gastrointest Endosc. 2017 May; 85(5):996-1001. PMID: 27693644.
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    10. Farrell CP, Overbey JR, Naik H, Nance D, McLaren GD, McLaren C, Zhou L, Desnick RJ, Parker CJ, Phillips JD. The D519G Polymorphism of Glyceronephosphate O-Acyltransferase Is a Risk Factor for Familial Porphyria Cutanea Tarda. PLoS One. 2016; 11(9):e0163322. PMID: 27661980.
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    11. Leproux A, Kim YM, Min JW, McLaren C, Chen WP, O'Sullivan TD, Lee SH, Chung PS, Tromberg BJ. Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging. J Biomed Opt. 2016 Jul 01; 21(7):74001. PMID: 27436049; PMCID: PMC4951543 [Available on 07/20/17].
    12. McLaren C, Barton JC, Subramaniam VN, Ramm GA, Phatak PD, Emond MJ, Gurrin LC, Adams PC, Powell LW, Anderson GJ, McLaren GD. Reply. Hepatology. 2016 06; 63(6):2058-60. PMID: 26845080; PMCID: PMC4874893 [Available on 06/01/17].
    13. McLaren C, Barton JC, Phatak PD, Emond MJ, Subramaniam VN, Gurrin LC, Adams PC, Powell LW, Ramm GA, Anderson GJ, McLaren GD. Reply. Hepatology. 2016 06; 63(6):2056-7. PMID: 26417986; PMCID: PMC4811743 [Available on 06/01/17].
    14. McLaren C, Emond MJ, Subramaniam VN, Phatak PD, Barton JC, Adams PC, Powell LW, Gurrin LC, Ramm GA, Anderson GJ, McLaren GD. Reply: To PMID 25605615. Hepatology. 2015 Dec; 62(6):1918-9. PMID: 25914125.
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    15. Chen JH, Chan S, Tang YT, Hon JS, Tseng PC, Cheriyan AT, Shah NR, Yeh DC, Lee SK, Chen WP, McLaren C, Su MY. Impact of positional difference on the measurement of breast density using MRI. Med Phys. 2015 May; 42(5):2268-75. PMID: 25979021; PMCID: PMC4401799.
    16. Zaloumis SG, Allen KJ, Bertalli NA, Turkovic L, Delatycki MB, Nicoll AJ, McLaren C, English DR, Hopper JL, Giles GG, Anderson GJ, Olynyk JK, Powell LW, Gurrin LC. Natural history of HFE simple heterozygosity for C282Y and H63D: a prospective 12-year study. J Gastroenterol Hepatol. 2015 Apr; 30(4):719-25. PMID: 25311314; PMCID: PMC4782752.
    17. McLaren C, Emond MJ, Subramaniam VN, Phatak PD, Barton JC, Adams PC, Goh JB, McDonald CJ, Powell LW, Gurrin LC, Allen KJ, Nickerson DA, Louie T, Ramm GA, Anderson GJ, McLaren GD. Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload. Hepatology. 2015 Aug; 62(2):429-39. PMID: 25605615; PMCID: PMC4508230.
    18. Billheimer D, Gerner EW, McLaren C, LaFleur B. Combined benefit of prediction and treatment: a criterion for evaluating clinical prediction models. Cancer Inform. 2014; 13(Suppl 2):93-103. PMID: 25336898; PMCID: PMC4197927.
    19. Linden KG, Leachman SA, Zager JS, Jakowatz JG, Viner JL, McLaren C, Barr RJ, Carpenter PM, Chen WP, Elmets CA, Tangrea JA, Lim SJ, Cochran AJ, Meyskens FL. A randomized, double-blind, placebo-controlled phase II clinical trial of lovastatin for various endpoints of melanoma pathobiology. Cancer Prev Res (Phila). 2014 May; 7(5):496-504. PMID: 24614012; PMCID: PMC4208700.
    20. Jia Z, Lilly MB, Koziol JA, Chen X, Xia XQ, Wang Y, Skarecky D, Sutton M, Sawyers A, Ruckle H, Carpenter PM, Wang-Rodriguez J, Jiang J, Deng M, Pan C, Zhu JG, McLaren C, Gurley MJ, Lee C, McClelland M, Ahlering T, Kattan MW, Mercola D. Generation of "virtual" control groups for single arm prostate cancer adjuvant trials. PLoS One. 2014; 9(1):e85010. PMID: 24465467; PMCID: PMC3897405.
    21. Mainous AG, Wright RU, Hulihan MM, Twal WO, McLaren C, Diaz VA, McLaren GD, Argraves WS, Grant AM. Elevated transferrin saturation, health-related quality of life and telomere length. Biometals. 2014 Feb; 27(1):135-41. PMID: 24337410; PMCID: PMC4034347.
    22. Chen JH, Bahri S, Mehta RS, Carpenter PM, McLaren C, Chen WP, Fwu PT, Hsiang DJ, Lane KT, Butler JA, Su MY. Impact of factors affecting the residual tumor size diagnosed by MRI following neoadjuvant chemotherapy in comparison to pathology. J Surg Oncol. 2014 Feb; 109(2):158-67. PMID: 24166728; PMCID: PMC4005994.
    23. Koh CY, Demirjian AN, Chen WP, McLaren C, Imagawa DK. Validation of revised American Joint Committee on Cancer staging for gallbladder cancer based on a single institution experience. Am Surg. 2013 Oct; 79(10):1045-9. PMID: 24160796; PMCID: PMC4017658.
    24. Davis BH, McLaren C, Carcio AJ, Wong L, Hedley BD, Keeney M, Curtis A, Culp NB. Determination of optimal replicate number for validation of imprecision using fluorescence cell-based assays: proposed practical method. Cytometry B Clin Cytom. 2013 Sep-Oct; 84(5):329-37. PMID: 24022856.
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    25. Chen JH, Pan WF, Kao J, Lu J, Chen LK, Kuo CC, Chang CK, Chen WP, McLaren C, Bahri S, Mehta RS, Su MY. Effect of taxane-based neoadjuvant chemotherapy on fibroglandular tissue volume and percent breast density in the contralateral normal breast evaluated by 3T MR. NMR Biomed. 2013 Dec; 26(12):1705-13. PMID: 23940080; PMCID: PMC3838444.
    26. Davis BH, McLaren C, Carcio AJ, Wong L, Hedley BD, Keeney M, Curtis A, Culp NB. Determination of optimal replicate number for validation of imprecision using fluorescence cell based assays: Proposed practical method. Cytometry B Clin Cytom. 2013 Jul 19. PMID: 23873644.
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    27. Adams PC, McLaren C, Speechley M, McLaren GD, Barton JC, Eckfeldt JH. HFE mutations in Caucasian participants of the Hemochromatosis and Iron Overload Screening study with serum ferritin level <1000 µg/L. Can J Gastroenterol. 2013 Jul; 27(7):390-2. PMID: 23862168; PMCID: PMC3956024.
    28. Mainous AG, Wright RU, Hulihan MM, Twal WO, McLaren C, Diaz VA, McLaren GD, Argraves WS, Grant AM. Telomere length and elevated iron: the influence of phenotype and HFE genotype. Am J Hematol. 2013 Jun; 88(6):492-6. PMID: 23512844; PMCID: PMC3784668.
    29. O'Sullivan TD, Leproux A, Chen JH, Bahri S, Matlock A, Roblyer D, McLaren C, Chen WP, Cerussi AE, Su MY, Tromberg BJ. Optical imaging correlates with magnetic resonance imaging breast density and reveals composition changes during neoadjuvant chemotherapy. Breast Cancer Res. 2013 Feb 22; 15(1):R14. PMID: 23433249; PMCID: PMC3672664.
    30. Murray JA, McLachlan S, Adams PC, Eckfeldt JH, Garner CP, Vulpe CD, Gordeuk VR, Brantner T, Leiendecker-Foster C, Killeen AA, Acton RT, Barcellos LF, Nickerson DA, Beckman KB, McLaren GD, McLaren C. Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians. Clin Gastroenterol Hepatol. 2013 Jul; 11(7):808-14. PMID: 23416278.
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    31. Jia Z, Wang Y, Hu Y, McLaren C, Yu Y, Ye K, Xia XQ, Koziol JA, Lernhardt W, McClelland M, Mercola D. A sample selection strategy to boost the statistical power of signature detection in cancer expression profile studies. Anticancer Agents Med Chem. 2013 Feb; 13(2):203-11. PMID: 22934703; PMCID: PMC3786411.
    32. Zell JA, Lin BS, Madson N, McLaren C, Gerner EW, Meyskens FL. Role of obesity in a randomized placebo-controlled trial of difluoromethylornithine (DFMO) + sulindac for the prevention of sporadic colorectal adenomas. Cancer Causes Control. 2012 Oct; 23(10):1739-44. PMID: 22907422; PMCID: PMC3443348.
    33. Pinn-Bingham M, Puthawala AA, Syed AM, Sharma A, Disaia P, Berman M, Tewari KS, Randall-Whitis L, Mahmood U, Ramsinghani N, Kuo J, Chen WP, McLaren C. Outcomes of high-dose-rate interstitial brachytherapy in the treatment of locally advanced cervical cancer: long-term results. Int J Radiat Oncol Biol Phys. 2013 Mar 01; 85(3):714-20. PMID: 22763030; PMCID: PMC3842617.
    34. McLaren C, McLachlan S, Garner CP, Vulpe CD, Gordeuk VR, Eckfeldt JH, Adams PC, Acton RT, Murray JA, Leiendecker-Foster C, Snively BM, Barcellos LF, Cook JD, McLaren GD. Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. PLoS One. 2012; 7(6):e38339. PMID: 22761678; PMCID: PMC3382217.
    35. Gordeuk VR, Lovato L, Barton J, Vitolins M, McLaren G, Acton R, McLaren C, Harris E, Speechley M, Eckfeldt JH, Diaz S, Sholinsky P, Adams P. Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation. Can J Gastroenterol. 2012 Jun; 26(6):345-9. PMID: 22720276; PMCID: PMC3378281.
    36. Adams PC, Speechley M, Barton JC, McLaren C, McLaren GD, Eckfeldt JH. Probability of C282Y homozygosity decreases as liver transaminase activities increase in participants with hyperferritinemia in the hemochromatosis and iron overload screening study. Hepatology. 2012 Jun; 55(6):1722-6. PMID: 22183642; PMCID: PMC3355194.
    37. Roblyer D, Ueda S, Cerussi A, Tanamai W, Durkin A, Mehta R, Hsiang D, Butler JA, McLaren C, Chen WP, Tromberg B. Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14626-31. PMID: 21852577; PMCID: PMC3167535.
    38. Mainous AG, Diaz VA, Everett CJ, Knoll ME, Hulihan MM, Grant AM, McLaren C, McLaren GD. IRon Overload screeNing tool (IRON): development of a tool to guide screening in primary care. Am J Hematol. 2011 Sep; 86(9):733-7. PMID: 21800355; PMCID: PMC3779368.
    39. Bertalli NA, Allen KJ, McLaren C, Turkovic L, Osborne NJ, Constantine CC, Delatycki MB, English DR, Giles GG, Hopper JL, Anderson GJ, Olynyk JK, Powell LW, Gurrin LC. A comparison of self-reported and record-linked blood donation history in an Australian cohort. Transfusion. 2011 Oct; 51(10):2189-98. PMID: 21985049.
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    40. McLaren C, Garner CP, Constantine CC, McLachlan S, Vulpe CD, Snively BM, Gordeuk VR, Nickerson DA, Cook JD, Leiendecker-Foster C, Beckman KB, Eckfeldt JH, Barcellos LF, Murray JA, Adams PC, Acton RT, Killeen AA, McLaren GD. Genome-wide association study identifies genetic loci associated with iron deficiency. PLoS One. 2011 Mar 31; 6(3):e17390. PMID: 21483845; PMCID: PMC3069025.
    41. Carroll RE, Benya RV, Turgeon DK, Vareed S, Neuman M, Rodriguez L, Kakarala M, Carpenter PM, McLaren C, Meyskens FL, Brenner DE. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia. Cancer Prev Res (Phila). 2011 Mar; 4(3):354-64. PMID: 21372035; PMCID: PMC4136551.
    42. Meyskens FL, McLaren C. Chemoprevention, risk reduction, therapeutic prevention, or preventive therapy? J Natl Cancer Inst. 2010 Dec 15; 102(24):1815-7. PMID: 21115881.
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    43. Garcia AM, McLaren C, Meyskens FL. Melanoma: is hair the root of the problem? Pigment Cell Melanoma Res. 2011 Feb; 24(1):110-8. PMID: 20880199; PMCID: PMC3768291.
    44. Allen KJ, Bertalli NA, Osborne NJ, Constantine CC, Delatycki MB, Nisselle AE, Nicoll AJ, Gertig DM, McLaren C, Giles GG, Hopper JL, Anderson GJ, Olynyk JK, Powell LW, Gurrin LC. HFE Cys282Tyr homozygotes with serum ferritin concentrations below 1000 microg/L are at low risk of hemochromatosis. Hepatology. 2010 Sep; 52(3):925-33. PMID: 20583211; PMCID: PMC2932765.
    45. Zell JA, McLaren C, Chen WP, Thompson PA, Gerner EW, Meyskens FL. Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients. J Natl Cancer Inst. 2010 Oct 06; 102(19):1513-6. PMID: 20798393; PMCID: PMC2950167.
    46. Chang KJ, Erickson RA, Chak A, Lightdale C, Chen YK, Binmoeller KF, Albers GC, Chen WP, McLaren C, Sivak MV, Lee JG, Isenberg GA, Wong RC. EUS compared with endoscopy plus transabdominal US in the initial diagnostic evaluation of patients with upper abdominal pain. Gastrointest Endosc. 2010 Nov; 72(5):967-74. PMID: 20650452; PMCID: PMC3775486.
    47. Thompson PA, Wertheim BC, Zell JA, Chen WP, McLaren C, LaFleur BJ, Meyskens FL, Gerner EW. Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma. Gastroenterology. 2010 Sep; 139(3):797-805, 805.e1. PMID: 20538001.
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    48. Nie K, Su MY, Chau MK, Chan S, Nguyen H, Tseng T, Huang Y, McLaren C, Nalcioglu O, Chen JH. Age- and race-dependence of the fibroglandular breast density analyzed on 3D MRI. Med Phys. 2010 Jun; 37(6):2770-6. PMID: 20632587; PMCID: PMC2885945.
    49. Osborne NJ, Gurrin LC, Allen KJ, Constantine CC, Delatycki MB, McLaren C, Gertig DM, Anderson GJ, Southey MC, Olynyk JK, Powell LW, Hopper JL, Giles GG, English DR. HFE C282Y homozygotes are at increased risk of breast and colorectal cancer. Hepatology. 2010 Apr; 51(4):1311-8. PMID: 20099304; PMCID: PMC3815603.
    50. Acton RT, Barton JC, Leiendecker-Foster C, Zaun C, McLaren C, Eckfeldt JH. Tumor necrosis factor-alpha promoter variants and iron phenotypes in 785 hemochromatosis and iron overload screening (HEIRS) study participants. Blood Cells Mol Dis. 2010 Apr 15; 44(4):252-6. PMID: 20178892; PMCID: PMC3836206.
    51. McLaren C, Barton JC, Eckfeldt JH, McLaren GD, Acton RT, Adams PC, Henkin LF, Gordeuk VR, Vulpe CD, Harris EL, Harrison BW, Reiss JA, Snively BM. Heritability of serum iron measures in the hemochromatosis and iron overload screening (HEIRS) family study. Am J Hematol. 2010 Feb; 85(2):101-5. PMID: 20095037.
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    52. Chorney JM, Torrey C, Blount R, McLaren C, Chen WP, Kain ZN. Healthcare provider and parent behavior and children's coping and distress at anesthesia induction. Anesthesiology. 2009 Dec; 111(6):1290-6. PMID: 19934874; PMCID: PMC2790460.
    53. Adams P, Barton JC, McLaren GD, Acton RT, Speechley M, McLaren C, Reboussin DM, Leiendecker-Foster C, Harris EL, Snively BM, Vogt T, Sholinsky P, Thomson E, Dawkins FW, Gordeuk VR, Eckfeldt JH. Screening for iron overload: lessons from the hemochromatosis and iron overload screening (HEIRS) study. Can J Gastroenterol. 2009 Nov; 23(11):769-72. PMID: 19893773; PMCID: PMC2777090.
    54. Constantine CC, Anderson GJ, Vulpe CD, McLaren C, Bahlo M, Yeap HL, Gertig DM, Osborne NJ, Bertalli NA, Beckman KB, Chen V, Matak P, McKie AT, Delatycki MB, Olynyk JK, English DR, Southey MC, Giles GG, Hopper JL, Allen KJ, Gurrin LC. A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis. Br J Haematol. 2009 Oct; 147(1):140-9. PMID: 19673882; PMCID: PMC2767327.
    55. Gurrin LC, Bertalli NA, Dalton GW, Osborne NJ, Constantine CC, McLaren C, English DR, Gertig DM, Delatycki MB, Nicoll AJ, Southey MC, Hopper JL, Giles GG, Anderson GJ, Olynyk JK, Powell LW, Allen KJ. HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity. Hepatology. 2009 Jul; 50(1):94-101. PMID: 19554541; PMCID: PMC3763940.
    56. McLaren C, Chen WP, Nie K, Su MY. Prediction of malignant breast lesions from MRI features: a comparison of artificial neural network and logistic regression techniques. Acad Radiol. 2009 Jul; 16(7):842-51. PMID: 19409817; PMCID: PMC2832583.
    57. Carpenter PM, Chen WP, Mendez A, McLaren C, Su MY. Angiogenesis in the progression of breast ductal proliferations. Int J Surg Pathol. 2011 Jun; 19(3):335-41. PMID: 19403546; PMCID: PMC3771508.
    58. Zell JA, Pelot D, Chen WP, McLaren C, Gerner EW, Meyskens FL. Risk of cardiovascular events in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas. Cancer Prev Res (Phila). 2009 Mar; 2(3):209-12. PMID: 19258540.
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    59. Wang X, Leiendecker-Foster C, Acton RT, Barton JC, McLaren C, McLaren GD, Gordeuk VR, Eckfeldt JH. Heme carrier protein 1 (HCP1) genetic variants in the Hemochromatosis and Iron Overload Screening (HEIRS) Study participants. Blood Cells Mol Dis. 2009 Mar-Apr; 42(2):150-4. PMID: 19176287.
      View in: PubMed
    60. McLaren C, Fujikawa-Brooks S, Chen WP, Gillen DL, Pelot D, Gerner EW, Meyskens FL. Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas. Cancer Prev Res (Phila). 2008 Dec; 1(7):514-21. PMID: 19139001.
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    61. McLaren GD, McLaren C, Adams PC, Barton JC, Reboussin DM, Gordeuk VR, Acton RT, Harris EL, Speechley MR, Sholinsky P, Dawkins FW, Snively BM, Vogt TM, Eckfeldt JH. Clinical manifestations of hemochromatosis in HFE C282Y homozygotes identified by screening. Can J Gastroenterol. 2008 Nov; 22(11):923-30. PMID: 19018338; PMCID: PMC2661195.
    62. Gurrin LC, Osborne NJ, Constantine CC, McLaren C, English DR, Gertig DM, Delatycki MB, Southey MC, Hopper JL, Giles GG, Anderson GJ, Olynyk JK, Powell LW, Allen KJ. The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis. Gastroenterology. 2008 Dec; 135(6):1945-52. PMID: 18848943.
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    63. Gordeuk VR, Reboussin DM, McLaren C, Barton JC, Acton RT, McLaren GD, Harris EL, Reiss JA, Adams PC, Speechley M, Phatak PD, Sholinsky P, Eckfeldt JH, Chen WP, Passmore L, Dawkins FW. Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population. Am J Hematol. 2008 Aug; 83(8):618-26. PMID: 18429050; PMCID: PMC3773165.
    64. Acton RT, Barton JC, Passmore LV, Adams PC, McLaren GD, Leiendecker-Foster C, Speechley MR, Harris EL, Castro O, Reiss JA, Snively BM, Harrison BW, McLaren C. Accuracy of family history of hemochromatosis or iron overload: the hemochromatosis and iron overload screening study. Clin Gastroenterol Hepatol. 2008 Aug; 6(8):934-8. PMID: 18585964; PMCID: PMC3779058.
    65. Meyskens FL, McLaren C, Pelot D, Fujikawa-Brooks S, Carpenter PM, Hawk E, Kelloff G, Lawson MJ, Kidao J, McCracken J, Albers CG, Ahnen DJ, Turgeon DK, Goldschmid S, Lance P, Hagedorn CH, Gillen DL, Gerner EW. Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev Res (Phila). 2008 Jun; 1(1):32-8. PMID: 18841250; PMCID: PMC2562024.
    66. Wong BJ, Karimi K, Devcic Z, McLaren C, Chen WP. Evolving attractive faces using morphing technology and a genetic algorithm: a new approach to determining ideal facial aesthetics. Laryngoscope. 2008 Jun; 118(6):962-74. PMID: 18401273; PMCID: PMC3786677.
    67. Constantine CC, Gurrin LC, McLaren C, Bahlo M, Anderson GJ, Vulpe CD, Forrest SM, Allen KJ, Gertig DM. SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis. BMC Med Genet. 2008 Mar 20; 9:18. PMID: 18366708; PMCID: PMC2289803.
    68. Simoneau AR, Gerner EW, Nagle R, Ziogas A, Fujikawa-Brooks S, Yerushalmi H, Ahlering TE, Lieberman R, McLaren C, Anton-Culver H, Meyskens FL. The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial. Cancer Epidemiol Biomarkers Prev. 2008 Feb; 17(2):292-9. PMID: 18268112; PMCID: PMC2515594.
    69. Barton JC, Acton RT, Leiendecker-Foster C, Lovato L, Adams PC, Eckfeldt JH, McLaren C, Reiss JA, McLaren GD, Reboussin DM, Gordeuk VR, Speechley MR, Press RD, Dawkins FW. Characteristics of participants with self-reported hemochromatosis or iron overload at HEIRS study initial screening. Am J Hematol. 2008 Feb; 83(2):126-32. PMID: 17726683; PMCID: PMC3773364.
    70. Allen KJ, Gurrin LC, Constantine CC, Osborne NJ, Delatycki MB, Nicoll AJ, McLaren C, Bahlo M, Nisselle AE, Vulpe CD, Anderson GJ, Southey MC, Giles GG, English DR, Hopper JL, Olynyk JK, Powell LW, Gertig DM. Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med. 2008 Jan 17; 358(3):221-30. PMID: 18199861.
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    71. McLaren C, Gordeuk VR, Chen WP, Barton JC, Acton RT, Speechley M, Castro O, Adams PC, Snively BM, Harris EL, Reboussin DM, McLachlan GJ, Bean R. Bivariate mixture modeling of transferrin saturation and serum ferritin concentration in Asians, African Americans, Hispanics, and whites in the Hemochromatosis and Iron Overload Screening (HEIRS) Study. Transl Res. 2008 Feb; 151(2):97-109. PMID: 18201677.
      View in: PubMed
    72. Walker AP, Tucker DC, Hall MA, Lohman K, Harrison H, Harrison BW, Reiss J, Acton RT, Adams PC, Diaz S, Holup J, Thomson E, Ellis SD, McLaren C. Results communication and patient education after screening for possible hemochromatosis and iron overload: experience from the HEIRS Study of a large ethnically and linguistically diverse group. Genet Med. 2007 Nov; 9(11):778-91. PMID: 18007147.
      View in: PubMed
    73. Hall MA, Barton JC, Adams PC, McLaren C, Reiss JA, Castro O, Ruggiero A, Acton RT, Power TE, Bent TC. Genetic screening for iron overload: No evidence of discrimination at 1 year. J Fam Pract. 2007 Oct; 56(10):829-34. PMID: 17908514.
      View in: PubMed
    74. Wenzel LB, Anderson R, Tucker DC, Palla S, Thomson E, Speechley M, Harrison H, Lewis-Jack O, Fadojutimi-Akinsiku M, Eckfeldt JH, Reiss JA, Rivers CA, Bookman E, Snively BM, McLaren C. Health-related quality of life in a racially diverse population screened for hemochromatosis: results from the Hemochromatosis and Iron Overload Screening (HEIRS) study. Genet Med. 2007 Oct; 9(10):705-12. PMID: 18073584.
      View in: PubMed
    75. McLaren C, Barton JC, Gordeuk VR, Wu L, Adams PC, Reboussin DM, Speechley M, Chang H, Acton RT, Harris EL, Ruggiero AM, Castro O. Determinants and characteristics of mean corpuscular volume and hemoglobin concentration in white HFE C282Y homozygotes in the hemochromatosis and iron overload screening study. Am J Hematol. 2007 Oct; 82(10):898-905. PMID: 17597476.
      View in: PubMed
    76. Harris EL, McLaren C, Reboussin DM, Gordeuk VR, Barton JC, Acton RT, McLaren GD, Vogt TM, Snively BM, Leiendecker-Foster C, Holup JL, Passmore LV, Eckfeldt JH, Lin E, Adams PC. Serum ferritin and transferrin saturation in Asians and Pacific Islanders. Arch Intern Med. 2007 Apr 09; 167(7):722-6. PMID: 17420432.
      View in: PubMed
    77. Dawkins FW, Gordeuk VR, Snively BM, Lovato L, Barton JC, Acton RT, McLaren GD, Leiendecker-Foster C, McLaren C, Adams PC, Speechley M, Harris EL, Jackson S, Thomson EJ. African Americans at risk for increased iron stores or liver disease. Am J Med. 2007 Aug; 120(8):734.e1-9. PMID: 17679134.
      View in: PubMed
    78. Rivers CA, Barton JC, Gordeuk VR, Acton RT, Speechley MR, Snively BM, Leiendecker-Foster C, Press RD, Adams PC, McLaren GD, Dawkins FW, McLaren C, Reboussin DM. Association of ferroportin Q248H polymorphism with elevated levels of serum ferritin in African Americans in the Hemochromatosis and Iron Overload Screening (HEIRS) Study. Blood Cells Mol Dis. 2007 May-Jun; 38(3):247-52. PMID: 17276706.
      View in: PubMed
    79. Steiner M, Leiendecker-Foster C, McLaren GD, Snively BM, McLaren C, Adams PC, Eckfeldt JH. Hemochromatosis (HFE) gene splice site mutation IVS5+1 G/A in North American Vietnamese with and without phenotypic evidence of iron overload. Transl Res. 2007 Feb; 149(2):92-5. PMID: 17240320.
      View in: PubMed
    80. Barton JC, Acton RT, Leiendecker-Foster C, Lovato L, Adams PC, McLaren GD, Eckfeldt JH, McLaren C, Reboussin DM, Gordeuk VR, Speechley MR, Reiss JA, Press RD, Dawkins FW. HFE C282Y homozygotes aged 25-29 years at HEIRS Study initial screening. Genet Test. 2007; 11(3):269-75. PMID: 17949288.
      View in: PubMed
    81. McLaren C, Li KT, McLaren GD, Gordeuk VR, Snively BM, Reboussin DM, Barton JC, Acton RT, Dawkins FW, Harris EL, Eckfeldt JH, Moses GC, Adams PC. Mixture models of serum iron measures in population screening for hemochromatosis and iron overload. Transl Res. 2006 Oct; 148(4):196-206. PMID: 17002922.
      View in: PubMed
    82. Gastañaga VM, McLaren C, Delfino RJ. Power calculations for generalized linear models in observational longitudinal studies: a simulation approach in SAS. Comput Methods Programs Biomed. 2006 Oct; 84(1):27-33. PMID: 16982112.
      View in: PubMed
    83. Schwindt CD, Tjoa T, Floro JN, McLaren C, Delfino RJ. Association of atopy to asthma severity and medication use in children. J Asthma. 2006 Aug; 43(6):439-46. PMID: 16952862.
      View in: PubMed
    84. Holcombe RF, McLaren C, Milovanovic T. Immunomodulation with low dose levamisole in patients with colonic polyps. Cancer Detect Prev. 2006; 30(1):94-8. PMID: 16458451.
      View in: PubMed
    85. Acton RT, Barton JC, Snively BM, McLaren C, Adams PC, Harris EL, Speechley MR, McLaren GD, Dawkins FW, Leiendecker-Foster C, Holup JL, Balasubramanyam A. Geographic and racial/ethnic differences in HFE mutation frequencies in the Hemochromatosis and Iron Overload Screening (HEIRS) Study. Ethn Dis. 2006; 16(4):815-21. PMID: 17061732.
      View in: PubMed
    86. Su MY, Yu HJ, Carpenter PM, McLaren C, Nalcioglu O. Pharmacokinetic parameters analyzed from mr contrast enhancement kinetics of multiple malignant and benign breast lesions detected in the same patients. Technol Cancer Res Treat. 2005 Jun; 4(3):255-63. PMID: 15896081.
      View in: PubMed
    87. Adams PC, Reboussin DM, Barton JC, McLaren C, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med. 2005 Apr 28; 352(17):1769-78. PMID: 15858186.
      View in: PubMed
    88. Adams PC, Reboussin DM, Leiendecker-Foster C, Moses GC, McLaren GD, McLaren C, Dawkins FW, Kasvosve I, Acton RT, Barton JC, Zaccaro D, Harris EL, Press R, Chang H, Eckfeldt JH. Comparison of the unsaturated iron-binding capacity with transferrin saturation as a screening test to detect C282Y homozygotes for hemochromatosis in 101,168 participants in the hemochromatosis and iron overload screening (HEIRS) study. Clin Chem. 2005 Jun; 51(6):1048-52. PMID: 15833784.
      View in: PubMed
    89. Barton JC, Acton RT, Dawkins FW, Adams PC, Lovato L, Leiendecker-Foster C, McLaren C, Reboussin DM, Speechley MR, Gordeuk VR, McLaren GD, Sholinsky P, Harris EL. Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in whites and blacks in the Hemochromatosis and Iron Overload Screening Study. Genet Test. 2005; 9(3):231-41. PMID: 16225403.
      View in: PubMed
    90. Carpenter PM, Linden KG, McLaren C, Li KT, Arain S, Barr RJ, Hite P, Sun JD, Meyskens FL. Nuclear morphometry and molecular biomarkers of actinic keratosis, sun-damaged, and nonexposed skin. Cancer Epidemiol Biomarkers Prev. 2004 Dec; 13(12):1996-2002. PMID: 15598753.
      View in: PubMed
    91. Shibuya TY, Kim S, Nguyen K, Do J, McLaren C, Li KT, Chen WP, Parikh P, Wadhwa A, Zi X, Chen VY, Wong HS, Armstrong WB, Yoo GH. Bioactive suture: a novel immunotherapy for head and neck cancer. Clin Cancer Res. 2004 Oct 15; 10(20):7088-99. PMID: 15501989.
      View in: PubMed
    92. Delfino RJ, Quintana PJ, Floro J, Gastañaga VM, Samimi BS, Kleinman MT, Liu LJ, Bufalino C, Wu CF, McLaren C. Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter. Environ Health Perspect. 2004 Jun; 112(8):932-41. PMID: 15175185; PMCID: PMC1242025.
    93. Su MY, Cheung YC, Fruehauf JP, Yu H, Nalcioglu O, Mechetner E, Kyshtoobayeva A, Chen SC, Hsueh S, McLaren C, Wan YL. Correlation of dynamic contrast enhancement MRI parameters with microvessel density and VEGF for assessment of angiogenesis in breast cancer. J Magn Reson Imaging. 2003 Oct; 18(4):467-77. PMID: 14508784.
      View in: PubMed
    94. McLaren C, Li KT, Garner CP, Beutler E, Gordeuk VR. Mixture distribution analysis of phenotypic markers reflecting HFE gene mutations. Blood. 2003 Dec 15; 102(13):4563-6. PMID: 12907432.
      View in: PubMed
    95. McLaren C, Barton JC, Adams PC, Harris EL, Acton RT, Press N, Reboussin DM, McLaren GD, Sholinsky P, Walker AP, Gordeuk VR, Leiendecker-Foster C, Dawkins FW, Eckfeldt JH, Mellen BG, Speechley M, Thomson E. Hemochromatosis and Iron Overload Screening (HEIRS) study design for an evaluation of 100,000 primary care-based adults. Am J Med Sci. 2003 Feb; 325(2):53-62. PMID: 12589228.
      View in: PubMed
    96. Linden KG, Carpenter PM, McLaren C, Barr RJ, Hite P, Sun JD, Li KT, Viner JL, Meyskens FL. Chemoprevention of nonmelanoma skin cancer: experience with a polyphenol from green tea. Recent Results Cancer Res. 2003; 163:165-71; discussion 264-6. PMID: 12903852.
      View in: PubMed
    97. Delfino RJ, Zeiger RS, Seltzer JM, Street DH, McLaren C. Association of asthma symptoms with peak particulate air pollution and effect modification by anti-inflammatory medication use. Environ Health Perspect. 2002 Oct; 110(10):A607-17. PMID: 12361942; PMCID: PMC1241047.
    98. Holloway RW, Mehta RS, Finkler NJ, Li KT, McLaren C, Parker RJ, Fruehauf JP. Association between in vitro platinum resistance in the EDR assay and clinical outcomes for ovarian cancer patients. Gynecol Oncol. 2002 Oct; 87(1):8-16. PMID: 12468336.
      View in: PubMed
    99. Ahlering TE, Skarecky DW, McLaren C, Weinberg AC. Seminal vesicle involvement in patients with D1 disease predicts early prostate specific antigen recurrence and metastasis after radical prostatectomy and early androgen ablation. Cancer. 2002 Mar 15; 94(6):1648-53. PMID: 11920524.
      View in: PubMed
    100. Shibuya TY, Nugyen N, McLaren C, Li KT, Wei WZ, Kim S, Yoo GH, Rogowski A, Ensley J, Sakr W. Clinical significance of poor CD3 response in head and neck cancer. Clin Cancer Res. 2002 Mar; 8(3):745-51. PMID: 11895904.
      View in: PubMed
    101. McLaren C, Li KT, Gordeuk VR, Hasselblad V, McLaren GD. Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey. Blood. 2001 Oct 15; 98(8):2345-51. PMID: 11588029.
      View in: PubMed
    102. McLaren C, Kambour EL, McLachlan GJ, Lukaski HC, Li X, Brittenham GM, McLaren GD. Patient-specific analysis of sequential haematological data by multiple linear regression and mixture distribution modelling. Stat Med. 2000 Jan 15; 19(1):83-98. PMID: 10623915.
      View in: PubMed
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