Dan Mercola

Title(s)Professor, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-1298
ORCID ORCID Icon0000-0002-0281-9840 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UCLA, LOS ANGELESM.S.09/1967Biophysics
    UCLA, LOS ANGELESPh.D.09/1969Biophysics
    U. of Southampton, Southampto, U.K..B.M.12/1981Medicine
    Oxford University, Oxford, U.K.1974Protein Crystallography
    Collapse Awards and Honors
    1972Science Citation Classic [publication]
    Oxford University1974M.A. deg. status
    San Diego Padres2004Medical All-Star
    UCI ICTS2011Mentor Award
    Veterans of Foreign Wars2013Prostate Cancer Research

    Collapse Overview 
    Collapse Overview
    Our lab is focused on the development of biomarkers for the prognosis of prostate and breast cancer through novel application of analytic and bioinformatic tools. We were the first to show that the microenvironment of prostate cancer exhibited gene expression changes that could be used to form a prognostic classifier. More recently novel applications of eQTL (Expression Quantitative Trait Loci) to test the hypothesis that SNPs of noncoding DNA, that were identified by application of lab-collected and curated tissues to Illumina Inc. DNA SNP arrays, were associated with the regulation of specific coding genes (Chen et al., 2015). We observed 47 significant associations between eight risk variants and the expression patterns of 46 genes (Chen et al., 2015). This is the first study to identify associations between multiple SNPs and multiple in-trans gene expression differences in cancer stroma. In an analysis of HER2 positive breast cancer, an aggressive form of breast cancer, we used expression analysis of cells and over 800 publicly available tissues combined with chip-on-chip, using a method patented by our lab, of RNA polymerase II to identify genes specifically expressed in HER2 positive tissues but not in cell lines indicating that the breast cancer microenvironment plays a role in the activation of HER2 receptors (Rahmatpanah et al., 2015). We have applied our bioinformatic experience to analysis of the immune system, a major constituent of the tumor microenvironment, by collection of human blood and analysis by RNAseq data of young and old donors. These methods revealed over 4000 significant gene expression changes of aged dendritic cells (Rahmatpanah et al., 2018). The differences reveal that DC from aged subjects display an activated state coupled with reduced antigen presentation which may be responsible for age-associated immune dysfunction. Current studies utilize a unique resource organized by our lab for the development of prostate cancer stroma primary cell lines of dozens a European American and African American prostate cancer patients. RNAseq analysis of the stroma cell lines revealed deficiencies in the immunological mechanisms of African American stroma which correlates with the more aggressive nature of prostate cancer in Africa Americans. These studies are continuing including use in a in vivo mouse model in collaboration with Dr. Xiaolin Zi.

    Collapse Research 
    Collapse Research Activities and Funding
    Development of the University of California-wide clinical genomic database
    UCOP University 0f California Office of the President MRI-19-601366Jan 1, 2019 - Dec 31, 2020
    Role: PI
    Description: The major goal of this project is to work with four of the six UC medical centers to obtain genomic test results from providers of tests for all patients and combined with with the clinical records of UC patients in the UC Clinical Data Warehouse
    The NEDD8 pathway mediated Skp2 degradation in chemoprevention of prostate cancer by FKA
    NIH/NCI 1R01CA193967-01A1Jul 1, 2016 - Jun 30, 2021
    Role: Co-investigator
    Description: The major goals of this project are to 1) Define mechanisms of FKA mediated Cullin1 deNEDDylation and Skp2 degradation; 2) Test the hypothesis that accumulation of Skp2 substrates is required for FKA mediated cell growth inhibition via cell cycle arrest and induction of apoptosis; 3) Perform pharmacokinetic/pharmacodynamics (PK/PD) and in vivo mechanistic studies on FKA mediated Skp2 degradation. Role: Co-investigator.
    San Antonio Center for Biomarkers of Risk for Prostate Cancer (SABOR)”, a multisite study
    NIH/NCI 3U01CA086402-14S2Jul 1, 2014 - Jun 30, 2020
    Role: UCI site-PI.
    Description: The goal of this program is to develop biomarkers based on blood, urine, and tissue using clinical values or, at UCI, molecular values that predict the upgrading of Gleason Scores of 3+3 or less as observed in diagnostic biopsies of prostate cancer patients to Gleason Scores of 3+4 or greater as observed in surgical prostatectomy tissue. Such upgrade predictors would, for example, overcome the under sampling believed to cause the deficient score from biopsy tissue and would be important in considering active surveillance regimens.
    The Prostate Cancer Tumor Microenvironment Exhibits Differentially Expressed Gene
    NIH U01CA152738Sep 1, 2010 - Jun 30, 2017
    Role: Principal Investigator
    Evaluation of Predictive Signatures of Prostate Cancer
    NIH U01CA114810Sep 30, 2005 - Jun 30, 2011
    Role: Principal Investigator
    NIH R01CA084107Jul 31, 2000 - Jun 30, 2005
    Role: Principal Investigator
    NIH U01CA084998Sep 30, 1999 - Mar 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Spatial Profiling of the Prostate Cancer Tumor Microenvironment Reveals Multiple Differences in Gene Expression and Correlation with Recurrence Risk. Cancers (Basel). 2022 Oct 08; 14(19). Kumar V, Randhawa P, Bilodeau R, Mercola D, McClelland M, Agrawal A, Nguyen J, Castro P, Ittmann MM, Rahmatpanah F. PMID: 36230846; PMCID: PMC9562240.
      View in: PubMed   Mentions: 2  
    2. Expression of Endogenous Retroviral RNA in Prostate Tumors has Prognostic Value and Shows Differences among Americans of African Versus European/Middle Eastern Ancestry. Cancers (Basel). 2021 Dec 17; 13(24). Kumar V, McClelland M, Nguyen J, De Robles G, Ittmann M, Castro P, Mercola D, Jia Z, Rahmatpanah F. PMID: 34944967; PMCID: PMC8699453.
      View in: PubMed   Mentions: 3  
    3. RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White Americans. Oncotarget. 2021 Jul 20; 12(15):1457-1469. Rahmatpanah F, Robles G, Lilly M, Keane T, Kumar V, Mercola D, Randhawa P, McClelland M. PMID: 34316327; PMCID: PMC8310667.
      View in: PubMed   Mentions: 8     Fields:    
    4. Transcriptome Analysis of Ovarian and Uterine Clear Cell Malignancies. Front Oncol. 2020; 10:598579. Alldredge J, Randall L, De Robles G, Agrawal A, Mercola D, Liu M, Randhawa P, Edwards R, McClelland M, Rahmatpanah F. PMID: 33415077; PMCID: PMC7784081.
      View in: PubMed   Mentions: 9  
    5. Transcriptome analysis of ovarian and uterine clear cell malignancies,. Transcriptome analysis of ovarian and uterine clear cell malignancies,. 2020; ePUB(ePUB):ePUB. Jill Alldredge, Leslie Randall, Gabriela De Robles, Anshu Agrawal, Dan Mercola, Marisa Liu, Pavneet Randhawa, Robert Edwards, Michael McClelland, Farah Rahmatpanah. View Publication.
    6. Transcriptional Profiling of Age-Associated Gene Expression Changes in Human Circulatory CD1c+ Myeloid Dendritic Cell Subset. J Gerontol A Biol Sci Med Sci. 2019 01 01; 74(1):9-15. Rahmatpanah F, Agrawal S, Scarfone VM, Kapadia S, Mercola D, Agrawal A. PMID: 29718193; PMCID: PMC6298184.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    7. Assessing Researcher Needs for a Virtual Biobank. Biopreserv Biobank. 2017 Jun; 15(3):203-210. van Draanen J, Davidson P, Bour-Jordan H, Bowman-Carpio L, Boyle D, Dubinett S, Gardner B, Gardner J, McFall C, Mercola D, Nakazono T, Soares S, Stoppler H, Tempero M, Vandenberg S, Wan YJ, Dry S. PMID: 27929677; PMCID: PMC5749588.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    8. Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model. Oncotarget. 2015 Dec 08; 6(39):41809-24. Li X, Yokoyama NN, Zhang S, Ding L, Liu HM, Lilly MB, Mercola D, Zi X. PMID: 26497688; PMCID: PMC4747190.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    9. Six stroma-based RNA markers diagnostic for prostate cancer in European-Americans validated at the RNA and protein levels in patients in China. Oncotarget. 2015 Jun 30; 6(18):16757-65. Zhu J, Pan C, Jiang J, Deng M, Gao H, Men B, McClelland M, Mercola D, Zhong WD, Jia Z. PMID: 26158290; PMCID: PMC4599305.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. Correction: Overexpression of periostin in stroma positively associated with aggressive prostate cancer. PLoS One. 2015; 10(6):e0130333. Tian Y, Choi CH, Li QK, Rahmatpanah FB, Chen X, Kim SR, Veltri R, Chia D, Zhang Z, Mercola D, Zhang H. PMID: 26043260; PMCID: PMC4456420.
      View in: PubMed   Mentions: 2     Fields:    
    11. When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow? Curr Pharmacol Rep. 2015 Dec 01; 1(6):420-433. Yokoyama NN, Denmon A, Uchio EM, Jordan M, Mercola D, Zi X. PMID: 26756023; PMCID: PMC4705552.
      View in: PubMed   Mentions: 7  
    12. Overexpression of periostin in stroma positively associated with aggressive prostate cancer. PLoS One. 2015; 10(3):e0121502. Tian Y, Choi CH, Li QK, Rahmatpanah FB, Chen X, Kim SR, Veltri R, Chia D, Zhang Z, Mercola D, Zhang H. PMID: 25781169; PMCID: PMC4362940.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    13. Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases. Hum Genet. 2015 Apr; 134(4):439-50. Helfand BT, Roehl KA, Cooper PR, McGuire BB, Fitzgerald LM, Cancel-Tassin G, Cornu JN, Bauer S, Van Blarigan EL, Chen X, Duggan D, Ostrander EA, Gwo-Shu M, Zhang ZF, Chang SC, Jeong S, Fontham ET, Smith G, Mohler JL, Berndt SI, McDonnell SK, Kittles R, Rybicki BA, Freedman M, Kantoff PW, Pomerantz M, Breyer JP, Smith JR, Rebbeck TR, Mercola D, Isaacs WB, Wiklund F, Cussenot O, Thibodeau SN, Schaid DJ, Cannon-Albright L, Cooney KA, Chanock SJ, Stanford JL, Chan JM, Witte J, Xu J, Bensen JT, Taylor JA, Catalona WJ. PMID: 25715684; PMCID: PMC4586077.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    14. The identification of trans-associations between prostate cancer GWAS SNPs and RNA expression differences in tumor-adjacent stroma. Oncotarget. 2015 Jan 30; 6(3):1865-73. Chen X, McClelland M, Jia Z, Rahmatpanah FB, Sawyers A, Trent J, Duggan D, Mercola D. PMID: 25638161; PMCID: PMC4359337.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors. Oncotarget. 2015 Jan 20; 6(2):1286-301. Rahmatpanah FB, Jia Z, Chen X, Char JE, Men B, Franke AC, Jones FE, McClelland M, Mercola D. PMID: 25428913; PMCID: PMC4359233.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-β and IGF signaling. Biomed Res Int. 2014; 2014:502093. Lee C, Jia Z, Rahmatpanah F, Zhang Q, Zi X, McClelland M, Mercola D. PMID: 25089270; PMCID: PMC4095744.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    17. The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis. PLoS One. 2014; 9(5):e96037. Ponti D, Bellenchi GC, Puca R, Bastianelli D, Maroder M, Ragona G, Roussel P, Thiry M, Mercola D, Calogero A. PMID: 24787739; PMCID: PMC4006901.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    18. Wnt signaling in castration-resistant prostate cancer: implications for therapy. Am J Clin Exp Urol. 2014 Apr 15; 2(1):27-44. Yokoyama NN, Shao S, Hoang BH, Mercola D, Zi X. PMID: 25143959; PMCID: PMC4219296.
      View in: PubMed   Mentions: 49  
    19. Generation of "virtual" control groups for single arm prostate cancer adjuvant trials. PLoS One. 2014; 9(1):e85010. Jia Z, Lilly MB, Koziol JA, Chen X, Xia XQ, Wang Y, Skarecky D, Sutton M, Sawyers A, Ruckle H, Carpenter PM, Wang-Rodriguez J, Jiang J, Deng M, Pan C, Zhu JG, McLaren CE, Gurley MJ, Lee C, McClelland M, Ahlering T, Kattan MW, Mercola D. PMID: 24465467; PMCID: PMC3897405.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. A gradient boosting algorithm for survival analysis via direct optimization of concordance index. Comput Math Methods Med. 2013; 2013:873595. Chen Y, Jia Z, Mercola D, Xie X. PMID: 24348746; PMCID: PMC3853154.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    21. Expression differences between African American and Caucasian prostate cancer tissue reveals that stroma is the site of aggressive changes. Int J Cancer. 2014 Jan 01; 134(1):81-91. Kinseth MA, Jia Z, Rahmatpanah F, Sawyers A, Sutton M, Wang-Rodriguez J, Mercola D, McGuire KL. PMID: 23754304; PMCID: PMC3800217.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    22. Natural products and transforming growth factor-beta (TGF-β) signaling in cancer development and progression. Curr Cancer Drug Targets. 2013 Jun; 13(5):500-5. Lee C, Zhang Q, Kozlowski J, Brendler C, B Soares M, Dash A, McClelland M, Mercola D. PMID: 23597196.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    23. Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention. Curr Cancer Drug Targets. 2013 Jun; 13(5):558-79. Tian X, Zhang S, Liu HM, Zhang YB, Blair CA, Mercola D, Sassone-Corsi P, Zi X. PMID: 23713993; PMCID: PMC3703250.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    24. A sample selection strategy to boost the statistical power of signature detection in cancer expression profile studies. Anticancer Agents Med Chem. 2013 Feb; 13(2):203-11. Jia Z, Wang Y, Hu Y, McLaren C, Yu Y, Ye K, Xia XQ, Koziol JA, Lernhardt W, McClelland M, Mercola D. PMID: 22934703; PMCID: PMC3786411.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer. PLoS One. 2013; 8(1):e54096. Pio R, Jia Z, Baron VT, Mercola D, UCI NCI SPECS Consortium of the Strategic Partners for the Evaluation of Cancer Signatures-Prostate . PMID: 23342084; PMCID: PMC3544741.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    26. Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer. PLoS One. 2012; 7(10):e46737. Khan S, Jutzy JM, Valenzuela MM, Turay D, Aspe JR, Ashok A, Mirshahidi S, Mercola D, Lilly MB, Wall NR. PMID: 23091600; PMCID: PMC3473028.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansCells
    27. An accurate prostate cancer prognosticator using a seven-gene signature plus Gleason score and taking cell type heterogeneity into account. PLoS One. 2012; 7(9):e45178. Chen X, Xu S, McClelland M, Rahmatpanah F, Sawyers A, Jia Z, Mercola D. PMID: 23028830; PMCID: PMC3460942.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    28. Expression changes in the stroma of prostate cancer predict subsequent relapse. PLoS One. 2012; 7(8):e41371. Jia Z, Rahmatpanah FB, Chen X, Lernhardt W, Wang Y, Xia XQ, Sawyers A, Sutton M, McClelland M, Mercola D. PMID: 22870216; PMCID: PMC3411675.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    29. TGF-β mediated DNA methylation in prostate cancer. Transl Androl Urol. 2012 Jun; 1(2):78-88. Lee C, Zhang Q, Zi X, Dash A, Soares MB, Rahmatpanah F, Jia Z, McClelland M, Mercola D. PMID: 25133096; PMCID: PMC4131550.
      View in: PubMed   Mentions: 10  
    30. Expression of HER2 in Breast Cancer Promotes a Massive Reorganization of Gene Activity and Suggests a Role for Epigenetic Regulation. J Data Mining Genomics Proteomics. 2012; 3. Rahmatpanah F, Jia Z, Chen X, Jones FE, McClelland M, Mercola D. PMID: 24009986; PMCID: PMC3760961.
      View in: PubMed   Mentions: 2  
    31. Diagnosis of prostate cancer using differentially expressed genes in stroma. Cancer Res. 2011 Apr 01; 71(7):2476-87. Jia Z, Wang Y, Sawyers A, Yao H, Rahmatpanah F, Xia XQ, Xu Q, Pio R, Turan T, Koziol JA, Goodison S, Carpenter P, Wang-Rodriguez J, Simoneau A, Meyskens F, Sutton M, Lernhardt W, Beach T, Monforte J, McClelland M, Mercola D. PMID: 21459804; PMCID: PMC3071046.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    32. Prostate cancer postoperative nomogram scores and obesity. PLoS One. 2011 Feb 24; 6(2):e17382. Major JM, Klonoff-Cohen HS, Pierce JP, Slymen DJ, Saltzstein SL, Macera CA, Mercola D, Kattan MW. PMID: 21390220; PMCID: PMC3044730.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. In silico estimates of tissue components in surgical samples based on expression profiling data. Cancer Res. 2010 Aug 15; 70(16):6448-55. Wang Y, Xia XQ, Jia Z, Sawyers A, Yao H, Wang-Rodriquez J, Mercola D, McClelland M. PMID: 20663908; PMCID: PMC4411177.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    34. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell. 2010 Jul 13; 18(1):23-38. Qi J, Nakayama K, Cardiff RD, Borowsky AD, Kaul K, Williams R, Krajewski S, Mercola D, Carpenter PM, Bowtell D, Ronai ZA. PMID: 20609350; PMCID: PMC2919332.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    35. Expression profile of human gingival fibroblasts induced by interleukin-1beta reveals central role of nuclear factor-kappa B in stabilizing human gingival fibroblasts during inflammation. J Periodontol. 2009 May; 80(5):833-49. Vardar-Sengul S, Arora S, Baylas H, Mercola D. PMID: 19405838; PMCID: PMC4150685.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    36. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther. 2009 Feb; 8(2):458-68. Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Hoang BH, Zi X. PMID: 19174556; PMCID: PMC2768341.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    37. Timing of consent for the research use of surgically removed tissue: is postoperative consenting acceptable? Cancer. 2009 Jan 01; 115(1):4-9. Hewitt R, Watson PH, Dhir R, Aamodt R, Thomas G, Mercola D, Grizzle WE, Morente MM. PMID: 19090013.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 2009 Jan 07; 28(1):21-33. Yu J, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E, Mustelin T. PMID: 19057511; PMCID: PMC2633077.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    39. Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip. Genome Biol. 2008; 9(11):R166. Arora S, Wang Y, Jia Z, Vardar-Sengul S, Munawar A, Doctor KS, Birrer M, McClelland M, Adamson E, Mercola D. PMID: 19032775; PMCID: PMC2614498.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    40. The wisdom of the commons: ensemble tree classifiers for prostate cancer prognosis. Bioinformatics. 2009 Jan 01; 25(1):54-60. Koziol JA, Feng AC, Jia Z, Wang Y, Goodison S, McClelland M, Mercola D. PMID: 18628288; PMCID: PMC2638928.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    41. Bcl-B expression in human epithelial and nonepithelial malignancies. Clin Cancer Res. 2008 May 15; 14(10):3011-21. Krajewska M, Kitada S, Winter JN, Variakojis D, Lichtenstein A, Zhai D, Cuddy M, Huang X, Luciano F, Baker CH, Kim H, Shin E, Kennedy S, Olson AH, Badzio A, Jassem J, Meinhold-Heerlein I, Duffy MJ, Schimmer AD, Tsao M, Brown E, Sawyers A, Andreeff M, Mercola D, Krajewski S, Reed JC. PMID: 18483366; PMCID: PMC4171052.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    42. Claudin-1 immunohistochemistry for distinguishing malignant from benign epithelial lesions of prostate. Prostate. 2007 Jun 15; 67(9):907-10. Krajewska M, Olson AH, Mercola D, Reed JC, Krajewski S. PMID: 17440968.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    43. Messenger RNAs under differential translational control in Ki-ras-transformed cells. Mol Cancer Res. 2006 Jan; 4(1):47-60. Spence J, Duggan BM, Eckhardt C, McClelland M, Mercola D. PMID: 16446406.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    44. "Promoter array" studies identify cohorts of genes directly regulated by methylation, copy number change, or transcription factor binding in human cancer cells. Ann N Y Acad Sci. 2005 Nov; 1058:162-85. Wang Y, Hayakawa J, Long F, Yu Q, Cho AH, Rondeau G, Welsh J, Mittal S, De Belle I, Adamson E, McClelland M, Mercola D. PMID: 16394135.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    45. Survey of differentially methylated promoters in prostate cancer cell lines. Neoplasia. 2005 Aug; 7(8):748-60. Wang Y, Yu Q, Cho AH, Rondeau G, Welsh J, Adamson E, Mercola D, McClelland M. PMID: 16207477; PMCID: PMC1501885.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    46. Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53. Cancer Res. 2005 Jun 15; 65(12):5133-43. Krones-Herzig A, Mittal S, Yule K, Liang H, English C, Urcis R, Soni T, Adamson ED, Mercola D. PMID: 15958557.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    47. Essential role of p38gamma in K-Ras transformation independent of phosphorylation. J Biol Chem. 2005 Jun 24; 280(25):23910-7. Tang J, Qi X, Mercola D, Han J, Chen G. PMID: 15851477; PMCID: PMC1224721.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    48. Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress. Mol Cell. 2004 Nov 19; 16(4):521-35. Hayakawa J, Mittal S, Wang Y, Korkmaz KS, Adamson E, English C, Ohmichi M, Omichi M, McClelland M, Mercola D. PMID: 15546613.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    49. From mRNA to tumor suppressor. Nat Genet. 2004 Sep; 36(9):937-8. Mercola D, Welsh J. PMID: 15340430.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    50. In silico dissection of cell-type-associated patterns of gene expression in prostate cancer. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):615-20. Stuart RO, Wachsman W, Berry CC, Wang-Rodriguez J, Wasserman L, Klacansky I, Masys D, Arden K, Goodison S, McClelland M, Wang Y, Sawyers A, Kalcheva I, Tarin D, Mercola D. PMID: 14722351; PMCID: PMC327196.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    51. Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. Cancer Cell Int. 2004 Jan 07; 4(1):1. Calogero A, Lombari V, De Gregorio G, Porcellini A, Ucci S, Arcella A, Caruso R, Gagliardi FM, Gulino A, Lanzetta G, Frati L, Mercola D, Ragona G. PMID: 14711380; PMCID: PMC324562.
      View in: PubMed   Mentions: 27  
    52. Antisense to the early growth response-1 gene (Egr-1) inhibits prostate tumor development in TRAMP mice. Ann N Y Acad Sci. 2003 Dec; 1002:197-216. Baron V, Duss S, Rhim J, Mercola D. PMID: 14751836.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    53. Egr1 signaling in prostate cancer. Cancer Biol Ther. 2003 Nov-Dec; 2(6):617-22. Adamson E, de Belle I, Mittal S, Wang Y, Hayakawa J, Korkmaz K, O'Hagan D, McClelland M, Mercola D. PMID: 14688464.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
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