Mercola, Dan

InstitutionUniversity of California, Irvine
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-1298
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    Collapse Research 
    Collapse Research Activities and Funding
    The Prostate Cancer Tumor Microenvironment Exhibits Differentially Expressed Gene
    NIH/NCI U01CA152738Sep 1, 2010 - Jun 30, 2016
    Role: Principal Investigator
    Evaluation of Predictive Signatures of Prostate Cancer
    NIH/NCI U01CA114810Sep 30, 2005 - Jun 30, 2011
    Role: Principal Investigator
    NIH/NCI R01CA084107Jul 31, 2000 - Jun 30, 2005
    Role: Principal Investigator
    NIH/NCI U01CA084998Sep 30, 1999 - Mar 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rahmatpanah F, Agrawal S, Scarfone VM, Kapadia S, Mercola D, Agrawal A. Transcriptional Profiling of Age-Associated Gene Expression Changes in Human Circulatory CD1c+ Myeloid Dendritic Cell Subset. J Gerontol A Biol Sci Med Sci. 2018 Apr 28. PMID: 29718193.
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    2. van Draanen J, Davidson P, Bour-Jordan H, Bowman-Carpio L, Boyle D, Dubinett S, Gardner B, Gardner J, McFall C, Mercola D, Nakazono T, Soares S, Stoppler H, Tempero M, Vandenberg S, Wan YJ, Dry S. Assessing Researcher Needs for a Virtual Biobank. Biopreserv Biobank. 2017 Jun; 15(3):203-210. PMID: 27929677.
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    3. Li X, Yokoyama NN, Zhang S, Ding L, Liu HM, Lilly MB, Mercola D, Zi X. Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model. Oncotarget. 2015 Dec 08; 6(39):41809-24. PMID: 26497688; PMCID: PMC4747190.
    4. Zhu J, Pan C, Jiang J, Deng M, Gao H, Men B, McClelland M, Mercola D, Zhong WD, Jia Z. Six stroma-based RNA markers diagnostic for prostate cancer in European-Americans validated at the RNA and protein levels in patients in China. Oncotarget. 2015 Jun 30; 6(18):16757-65. PMID: 26158290; PMCID: PMC4599305.
    5. Tian Y, Choi CH, Li QK, Rahmatpanah FB, Chen X, Kim SR, Veltri R, Chia D, Zhang Z, Mercola D, Zhang H. Correction: Overexpression of periostin in stroma positively associated with aggressive prostate cancer. PLoS One. 2015; 10(6):e0130333. PMID: 26043260.
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    6. Yokoyama NN, Denmon A, Uchio EM, Jordan M, Mercola D, Zi X. When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow? Curr Pharmacol Rep. 2015 Dec 01; 1(6):420-433. PMID: 26756023.
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    7. Tian Y, Choi CH, Li QK, Rahmatpanah FB, Chen X, Kim SR, Veltri R, Chia D, Zhang Z, Mercola D, Zhang H. Overexpression of periostin in stroma positively associated with aggressive prostate cancer. PLoS One. 2015; 10(3):e0121502. PMID: 25781169.
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    8. Helfand BT, Roehl KA, Cooper PR, McGuire BB, Fitzgerald LM, Cancel-Tassin G, Cornu JN, Bauer S, Van Blarigan EL, Chen X, Duggan D, Ostrander EA, Gwo-Shu M, Zhang ZF, Chang SC, Jeong S, Fontham ET, Smith G, Mohler JL, Berndt SI, McDonnell SK, Kittles R, Rybicki BA, Freedman M, Kantoff PW, Pomerantz M, Breyer JP, Smith JR, Rebbeck TR, Mercola D, Isaacs WB, Wiklund F, Cussenot O, Thibodeau SN, Schaid DJ, Cannon-Albright L, Cooney KA, Chanock SJ, Stanford JL, Chan JM, Witte J, Xu J, Bensen JT, Taylor JA, Catalona WJ. Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases. Hum Genet. 2015 Apr; 134(4):439-50. PMID: 25715684.
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    9. Chen X, McClelland M, Jia Z, Rahmatpanah FB, Sawyers A, Trent J, Duggan D, Mercola D. The identification of trans-associations between prostate cancer GWAS SNPs and RNA expression differences in tumor-adjacent stroma. Oncotarget. 2015 Jan 30; 6(3):1865-73. PMID: 25638161; PMCID: PMC4359337.
    10. Rahmatpanah FB, Jia Z, Chen X, Char JE, Men B, Franke AC, Jones FE, McClelland M, Mercola D. A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors. Oncotarget. 2015 Jan 20; 6(2):1286-301. PMID: 25428913; PMCID: PMC4359233.
    11. Lee C, Jia Z, Rahmatpanah F, Zhang Q, Zi X, McClelland M, Mercola D. Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-ß and IGF signaling. Biomed Res Int. 2014; 2014:502093. PMID: 25089270; PMCID: PMC4095744.
    12. Ponti D, Bellenchi GC, Puca R, Bastianelli D, Maroder M, Ragona G, Roussel P, Thiry M, Mercola D, Calogero A. The transcription factor EGR1 localizes to the nucleolus and is linked to suppression of ribosomal precursor synthesis. PLoS One. 2014; 9(5):e96037. PMID: 24787739; PMCID: PMC4006901.
    13. Yokoyama NN, Shao S, Hoang BH, Mercola D, Zi X. Wnt signaling in castration-resistant prostate cancer: implications for therapy. Am J Clin Exp Urol. 2014 Apr 15; 2(1):27-44. PMID: 25143959; PMCID: PMC4219296.
    14. Jia Z, Lilly MB, Koziol JA, Chen X, Xia XQ, Wang Y, Skarecky D, Sutton M, Sawyers A, Ruckle H, Carpenter PM, Wang-Rodriguez J, Jiang J, Deng M, Pan C, Zhu JG, McLaren CE, Gurley MJ, Lee C, McClelland M, Ahlering T, Kattan MW, Mercola D. Generation of "virtual" control groups for single arm prostate cancer adjuvant trials. PLoS One. 2014; 9(1):e85010. PMID: 24465467; PMCID: PMC3897405.
    15. Chen Y, Jia Z, Mercola D, Xie X. A gradient boosting algorithm for survival analysis via direct optimization of concordance index. Comput Math Methods Med. 2013; 2013:873595. PMID: 24348746; PMCID: PMC3853154.
    16. Kinseth MA, Jia Z, Rahmatpanah F, Sawyers A, Sutton M, Wang-Rodriguez J, Mercola D, McGuire KL. Expression differences between African American and Caucasian prostate cancer tissue reveals that stroma is the site of aggressive changes. Int J Cancer. 2014 Jan 01; 134(1):81-91. PMID: 23754304; PMCID: PMC3800217.
    17. Lee C, Zhang Q, Kozlowski J, Brendler C, B Soares M, Dash A, McClelland M, Mercola D. Natural products and transforming growth factor-beta (TGF-ß) signaling in cancer development and progression. Curr Cancer Drug Targets. 2013 Jun; 13(5):500-5. PMID: 23597196.
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    18. Tian X, Zhang S, Liu HM, Zhang YB, Blair CA, Mercola D, Sassone-Corsi P, Zi X. Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention. Curr Cancer Drug Targets. 2013 Jun; 13(5):558-79. PMID: 23713993; PMCID: PMC3703250.
    19. Jia Z, Wang Y, Hu Y, McLaren C, Yu Y, Ye K, Xia XQ, Koziol JA, Lernhardt W, McClelland M, Mercola D. A sample selection strategy to boost the statistical power of signature detection in cancer expression profile studies. Anticancer Agents Med Chem. 2013 Feb; 13(2):203-11. PMID: 22934703; PMCID: PMC3786411.
    20. Pio R, Jia Z, Baron VT, Mercola D. Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer. PLoS One. 2013; 8(1):e54096. PMID: 23342084; PMCID: PMC3544741.
    21. Khan S, Jutzy JM, Valenzuela MM, Turay D, Aspe JR, Ashok A, Mirshahidi S, Mercola D, Lilly MB, Wall NR. Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer. PLoS One. 2012; 7(10):e46737. PMID: 23091600; PMCID: PMC3473028.
    22. Chen X, Xu S, McClelland M, Rahmatpanah F, Sawyers A, Jia Z, Mercola D. An accurate prostate cancer prognosticator using a seven-gene signature plus Gleason score and taking cell type heterogeneity into account. PLoS One. 2012; 7(9):e45178. PMID: 23028830; PMCID: PMC3460942.
    23. Jia Z, Rahmatpanah FB, Chen X, Lernhardt W, Wang Y, Xia XQ, Sawyers A, Sutton M, McClelland M, Mercola D. Expression changes in the stroma of prostate cancer predict subsequent relapse. PLoS One. 2012; 7(8):e41371. PMID: 22870216; PMCID: PMC3411675.
    24. Lee C, Zhang Q, Zi X, Dash A, Soares MB, Rahmatpanah F, Jia Z, McClelland M, Mercola D. TGF-ß mediated DNA methylation in prostate cancer. Transl Androl Urol. 2012 Jun; 1(2):78-88. PMID: 25133096.
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    25. Rahmatpanah F, Jia Z, Chen X, Jones FE, McClelland M, Mercola D. Expression of HER2 in Breast Cancer Promotes a Massive Reorganization of Gene Activity and Suggests a Role for Epigenetic Regulation. J Data Mining Genomics Proteomics. 2012; 3. PMID: 24009986.
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    26. Jia Z, Wang Y, Sawyers A, Yao H, Rahmatpanah F, Xia XQ, Xu Q, Pio R, Turan T, Koziol JA, Goodison S, Carpenter P, Wang-Rodriguez J, Simoneau A, Meyskens F, Sutton M, Lernhardt W, Beach T, Monforte J, McClelland M, Mercola D. Diagnosis of prostate cancer using differentially expressed genes in stroma. Cancer Res. 2011 Apr 01; 71(7):2476-87. PMID: 21459804; PMCID: PMC3071046.
    27. Major JM, Klonoff-Cohen HS, Pierce JP, Slymen DJ, Saltzstein SL, Macera CA, Mercola D, Kattan MW. Prostate cancer postoperative nomogram scores and obesity. PLoS One. 2011 Feb 24; 6(2):e17382. PMID: 21390220; PMCID: PMC3044730.
    28. Wang Y, Xia XQ, Jia Z, Sawyers A, Yao H, Wang-Rodriquez J, Mercola D, McClelland M. In silico estimates of tissue components in surgical samples based on expression profiling data. Cancer Res. 2010 Aug 15; 70(16):6448-55. PMID: 20663908; PMCID: PMC4411177.
    29. Qi J, Nakayama K, Cardiff RD, Borowsky AD, Kaul K, Williams R, Krajewski S, Mercola D, Carpenter PM, Bowtell D, Ronai ZA. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell. 2010 Jul 13; 18(1):23-38. PMID: 20609350; PMCID: PMC2919332.
    30. Vardar-Sengul S, Arora S, Baylas H, Mercola D. Expression profile of human gingival fibroblasts induced by interleukin-1beta reveals central role of nuclear factor-kappa B in stabilizing human gingival fibroblasts during inflammation. J Periodontol. 2009 May; 80(5):833-49. PMID: 19405838; PMCID: PMC4150685.
    31. Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Hoang BH, Zi X. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther. 2009 Feb; 8(2):458-68. PMID: 19174556; PMCID: PMC2768341.
    32. Hewitt R, Watson PH, Dhir R, Aamodt R, Thomas G, Mercola D, Grizzle WE, Morente MM. Timing of consent for the research use of surgically removed tissue: is postoperative consenting acceptable? Cancer. 2009 Jan 01; 115(1):4-9. PMID: 19090013.
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    33. Yu J, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E, Mustelin T. PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 2009 Jan 07; 28(1):21-33. PMID: 19057511; PMCID: PMC2633077.
    34. Arora S, Wang Y, Jia Z, Vardar-Sengul S, Munawar A, Doctor KS, Birrer M, McClelland M, Adamson E, Mercola D. Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip. Genome Biol. 2008; 9(11):R166. PMID: 19032775; PMCID: PMC2614498.
    35. Koziol JA, Feng AC, Jia Z, Wang Y, Goodison S, McClelland M, Mercola D. The wisdom of the commons: ensemble tree classifiers for prostate cancer prognosis. Bioinformatics. 2009 Jan 01; 25(1):54-60. PMID: 18628288; PMCID: PMC2638928.
    36. Krajewska M, Kitada S, Winter JN, Variakojis D, Lichtenstein A, Zhai D, Cuddy M, Huang X, Luciano F, Baker CH, Kim H, Shin E, Kennedy S, Olson AH, Badzio A, Jassem J, Meinhold-Heerlein I, Duffy MJ, Schimmer AD, Tsao M, Brown E, Sawyers A, Andreeff M, Mercola D, Krajewski S, Reed JC. Bcl-B expression in human epithelial and nonepithelial malignancies. Clin Cancer Res. 2008 May 15; 14(10):3011-21. PMID: 18483366; PMCID: PMC4171052.
    37. Krajewska M, Olson AH, Mercola D, Reed JC, Krajewski S. Claudin-1 immunohistochemistry for distinguishing malignant from benign epithelial lesions of prostate. Prostate. 2007 Jun 15; 67(9):907-10. PMID: 17440968.
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    38. Spence J, Duggan BM, Eckhardt C, McClelland M, Mercola D. Messenger RNAs under differential translational control in Ki-ras-transformed cells. Mol Cancer Res. 2006 Jan; 4(1):47-60. PMID: 16446406.
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    39. Wang Y, Hayakawa J, Long F, Yu Q, Cho AH, Rondeau G, Welsh J, Mittal S, De Belle I, Adamson E, McClelland M, Mercola D. "Promoter array" studies identify cohorts of genes directly regulated by methylation, copy number change, or transcription factor binding in human cancer cells. Ann N Y Acad Sci. 2005 Nov; 1058:162-85. PMID: 16394135.
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    40. Wang Y, Yu Q, Cho AH, Rondeau G, Welsh J, Adamson E, Mercola D, McClelland M. Survey of differentially methylated promoters in prostate cancer cell lines. Neoplasia. 2005 Aug; 7(8):748-60. PMID: 16207477; PMCID: PMC1501885.
    41. Krones-Herzig A, Mittal S, Yule K, Liang H, English C, Urcis R, Soni T, Adamson ED, Mercola D. Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53. Cancer Res. 2005 Jun 15; 65(12):5133-43. PMID: 15958557.
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    42. Tang J, Qi X, Mercola D, Han J, Chen G. Essential role of p38gamma in K-Ras transformation independent of phosphorylation. J Biol Chem. 2005 Jun 24; 280(25):23910-7. PMID: 15851477; PMCID: PMC1224721.
    43. Hayakawa J, Mittal S, Wang Y, Korkmaz KS, Adamson E, English C, Ohmichi M, Omichi M, McClelland M, Mercola D. Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress. Mol Cell. 2004 Nov 19; 16(4):521-35. PMID: 15546613.
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    44. Mercola D, Welsh J. From mRNA to tumor suppressor. Nat Genet. 2004 Sep; 36(9):937-8. PMID: 15340430.
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    45. Stuart RO, Wachsman W, Berry CC, Wang-Rodriguez J, Wasserman L, Klacansky I, Masys D, Arden K, Goodison S, McClelland M, Wang Y, Sawyers A, Kalcheva I, Tarin D, Mercola D. In silico dissection of cell-type-associated patterns of gene expression in prostate cancer. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):615-20. PMID: 14722351; PMCID: PMC327196.
    46. Calogero A, Lombari V, De Gregorio G, Porcellini A, Ucci S, Arcella A, Caruso R, Gagliardi FM, Gulino A, Lanzetta G, Frati L, Mercola D, Ragona G. Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. Cancer Cell Int. 2004 Jan 07; 4(1):1. PMID: 14711380.
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    47. Baron V, Duss S, Rhim J, Mercola D. Antisense to the early growth response-1 gene (Egr-1) inhibits prostate tumor development in TRAMP mice. Ann N Y Acad Sci. 2003 Dec; 1002:197-216. PMID: 14751836.
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    48. Adamson E, de Belle I, Mittal S, Wang Y, Hayakawa J, Korkmaz K, O'Hagan D, McClelland M, Mercola D. Egr1 signaling in prostate cancer. Cancer Biol Ther. 2003 Nov-Dec; 2(6):617-22. PMID: 14688464.
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    49. Baron V, De Gregorio G, Krones-Herzig A, Virolle T, Calogero A, Urcis R, Mercola D. Inhibition of Egr-1 expression reverses transformation of prostate cancer cells in vitro and in vivo. Oncogene. 2003 Jul 03; 22(27):4194-204. PMID: 12833142.
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    50. Hayakawa J, Depatie C, Ohmichi M, Mercola D. The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair. J Biol Chem. 2003 Jun 06; 278(23):20582-92. PMID: 12663670.
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    51. Krones-Herzig A, Adamson E, Mercola D. Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3233-8. PMID: 12629205; PMCID: PMC152275.
    52. De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED. In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1. J Biol Chem. 2003 Apr 18; 278(16):14306-12. PMID: 12562764.
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    53. Virolle T, Krones-Herzig A, Baron V, De Gregorio G, Adamson ED, Mercola D. Egr1 promotes growth and survival of prostate cancer cells. Identification of novel Egr1 target genes. J Biol Chem. 2003 Apr 04; 278(14):11802-10. PMID: 12556466.
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    54. Yang YM, Bost F, Charbono W, Dean N, McKay R, Rhim JS, Depatie C, Mercola D. C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma. Clin Cancer Res. 2003 Jan; 9(1):391-401. PMID: 12538493.
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    55. Adamson ED, Mercola D. Egr1 transcription factor: multiple roles in prostate tumor cell growth and survival. Tumour Biol. 2002 Mar-Apr; 23(2):93-102. PMID: 12065847.
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    56. Smeal T, Binetruy B, Mercola D, Birrer M, Karin M. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature. 1991 Dec 12; 354(6353):494-6. PMID: 1749429.
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    57. Ragona G, Edwards SA, Mercola D, Adamson ED, Calogero A. The transcriptional factor Egr-1 is synthesized by baculovirus-infected insect cells in an active, DNA-binding form. DNA Cell Biol. 1991 Jan-Feb; 10(1):61-6. PMID: 1991050.
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