Loading...

Mclaren, Gordon D.

TitleAdjunct Professor
InstitutionUniversity of California, Irvine
DepartmentMedicine
Address1001 Health Sciences Road
CA 92697-3950
Phone(562) 826-8000
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Genetic Modifiers of Iron Status in Hemochromatosis HFE C282Y Homozygotes
    NIH/NIDDK R24DK099846Sep 1, 2014 - Jun 30, 2017
    Role: Principal Investigator
    Genetic Modifiers of Iron Status in Hemochromatosis HFE C282Y Homozygotes
    NIH/NIDDK R24DK093433Sep 15, 2011 - Aug 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Adams P, Altes A, Brissot P, Butzeck B, Cabantchik I, Cançado R, Distante S, Evans P, Evans R, Ganz T, Girelli D, Hultcrantz R, McLaren G, Marris B, Milman N, Nemeth E, Nielsen P, Pineau B, Piperno A, Porto G, Prince D, Ryan J, Sanchez M, Santos P, Swinkels D, Teixeira E, Toska K, Vanclooster A, White D. Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype. Hepatol Int. 2018 Mar; 12(2):83-86. PMID: 29589198.
      View in: PubMed
    2. McLaren G, Barton JC, Ramm GA, Emond MJ, Subramaniam VN, Phatak PD, Adams PC, Powell LW, Gurrin LC, Anderson GJ, McLaren CE. Reply. Hepatology. 2017 03; 65(3):1072-1073. PMID: 28010035.
      View in: PubMed
    3. Barton JC, Chen WP, Emond MJ, Phatak PD, Subramaniam VN, Adams PC, Gurrin LC, Anderson GJ, Ramm GA, Powell LW, Allen KJ, Phillips JD, Parker CJ, McLaren G, McLaren CE. GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes. Blood Cells Mol Dis. 2017 03; 63:15-20. PMID: 27936396.
      View in: PubMed
    4. Farrell CP, Overbey JR, Naik H, Nance D, McLaren G, McLaren CE, Zhou L, Desnick RJ, Parker CJ, Phillips JD. The D519G Polymorphism of Glyceronephosphate O-Acyltransferase Is a Risk Factor for Familial Porphyria Cutanea Tarda. PLoS One. 2016; 11(9):e0163322. PMID: 27661980.
      View in: PubMed
    5. McLaren CE, Barton JC, Subramaniam VN, Ramm GA, Phatak PD, Emond MJ, Gurrin LC, Adams PC, Powell LW, Anderson GJ, McLaren G. Reply. Hepatology. 2016 06; 63(6):2058-60. PMID: 26845080; PMCID: PMC4874893 [Available on 06/01/17].
    6. McLaren CE, Barton JC, Phatak PD, Emond MJ, Subramaniam VN, Gurrin LC, Adams PC, Powell LW, Ramm GA, Anderson GJ, McLaren G. Reply. Hepatology. 2016 06; 63(6):2056-7. PMID: 26417986; PMCID: PMC4811743 [Available on 06/01/17].
    7. McLaren CE, Emond MJ, Subramaniam VN, Phatak PD, Barton JC, Adams PC, Powell LW, Gurrin LC, Ramm GA, Anderson GJ, McLaren G. Reply: To PMID 25605615. Hepatology. 2015 Dec; 62(6):1918-9. PMID: 25914125.
      View in: PubMed
    8. McLaren CE, Emond MJ, Subramaniam VN, Phatak PD, Barton JC, Adams PC, Goh JB, McDonald CJ, Powell LW, Gurrin LC, Allen KJ, Nickerson DA, Louie T, Ramm GA, Anderson GJ, McLaren G. Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload. Hepatology. 2015 Aug; 62(2):429-39. PMID: 25605615; PMCID: PMC4508230.
    9. Mainous AG, Wright RU, Hulihan MM, Twal WO, McLaren CE, Diaz VA, McLaren G, Argraves WS, Grant AM. Elevated transferrin saturation, health-related quality of life and telomere length. Biometals. 2014 Feb; 27(1):135-41. PMID: 24337410; PMCID: PMC4034347.
    10. Adams PC, McLaren CE, Speechley M, McLaren G, Barton JC, Eckfeldt JH. HFE mutations in Caucasian participants of the Hemochromatosis and Iron Overload Screening study with serum ferritin level <1000 µg/L. Can J Gastroenterol. 2013 Jul; 27(7):390-2. PMID: 23862168; PMCID: PMC3956024.
    11. Mainous AG, Wright RU, Hulihan MM, Twal WO, McLaren CE, Diaz VA, McLaren G, Argraves WS, Grant AM. Telomere length and elevated iron: the influence of phenotype and HFE genotype. Am J Hematol. 2013 Jun; 88(6):492-6. PMID: 23512844; PMCID: PMC3784668.
    12. Piazza G, Anderson FA, Ortel TL, Cox MJ, Rosenberg DJ, Rahimian S, Pendergast WJ, McLaren G, Welker JA, Akus JJ, Stevens SM, Elliott CG, Freeman AL, Patton WF, Dabbagh O, Wyman A, Huang W, Rao AF, Goldhaber SZ. Randomized trial of physician alerts for thromboprophylaxis after discharge. Am J Med. 2013 May; 126(5):435-42. PMID: 23510945.
      View in: PubMed
    13. Murray JA, McLachlan S, Adams PC, Eckfeldt JH, Garner CP, Vulpe CD, Gordeuk VR, Brantner T, Leiendecker-Foster C, Killeen AA, Acton RT, Barcellos LF, Nickerson DA, Beckman KB, McLaren G, McLaren CE. Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians. Clin Gastroenterol Hepatol. 2013 Jul; 11(7):808-14. PMID: 23416278.
      View in: PubMed
    14. McLaren CE, McLachlan S, Garner CP, Vulpe CD, Gordeuk VR, Eckfeldt JH, Adams PC, Acton RT, Murray JA, Leiendecker-Foster C, Snively BM, Barcellos LF, Cook JD, McLaren G. Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. PLoS One. 2012; 7(6):e38339. PMID: 22761678; PMCID: PMC3382217.
    15. Khomenko T, Kolodney J, Pinto JT, McLaren G, Deng X, Chen L, Tolstanova G, Paunovic B, Krasnikov BF, Hoa N, Cooper AJ, Szabo S. New mechanistic explanation for the localization of ulcers in the rat duodenum: role of iron and selective uptake of cysteamine. Arch Biochem Biophys. 2012 Sep 01; 525(1):60-70. PMID: 22684023.
      View in: PubMed
    16. Gordeuk VR, Lovato L, Barton J, Vitolins M, McLaren G, Acton R, McLaren C, Harris E, Speechley M, Eckfeldt JH, Diaz S, Sholinsky P, Adams P. Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation. Can J Gastroenterol. 2012 Jun; 26(6):345-9. PMID: 22720276; PMCID: PMC3378281.
    17. Adams PC, Speechley M, Barton JC, McLaren CE, McLaren G, Eckfeldt JH. Probability of C282Y homozygosity decreases as liver transaminase activities increase in participants with hyperferritinemia in the hemochromatosis and iron overload screening study. Hepatology. 2012 Jun; 55(6):1722-6. PMID: 22183642; PMCID: PMC3355194.
    18. Frazer DM, Wilkins SJ, Darshan D, Badrick AC, McLaren G, Anderson GJ. Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression. Br J Haematol. 2012 Jun; 157(5):615-26. PMID: 22449175.
      View in: PubMed
    19. Mainous AG, Diaz VA, Everett CJ, Knoll ME, Hulihan MM, Grant AM, McLaren CE, McLaren G. IRon Overload screeNing tool (IRON): development of a tool to guide screening in primary care. Am J Hematol. 2011 Sep; 86(9):733-7. PMID: 21800355; PMCID: PMC3779368.
    20. McLaren CE, Garner CP, Constantine CC, McLachlan S, Vulpe CD, Snively BM, Gordeuk VR, Nickerson DA, Cook JD, Leiendecker-Foster C, Beckman KB, Eckfeldt JH, Barcellos LF, Murray JA, Adams PC, Acton RT, Killeen AA, McLaren G. Genome-wide association study identifies genetic loci associated with iron deficiency. PLoS One. 2011 Mar 31; 6(3):e17390. PMID: 21483845; PMCID: PMC3069025.
    21. Phatak P, Brissot P, Wurster M, Adams PC, Bonkovsky HL, Gross J, Malfertheiner P, McLaren G, Niederau C, Piperno A, Powell LW, Russo MW, Stoelzel U, Stremmel W, Griffel L, Lynch N, Zhang Y, Pietrangelo A. A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis. Hepatology. 2010 Nov; 52(5):1671-779. PMID: 20814896; PMCID: PMC3034044.
    22. McLaren CE, Barton JC, Eckfeldt JH, McLaren G, Acton RT, Adams PC, Henkin LF, Gordeuk VR, Vulpe CD, Harris EL, Harrison BW, Reiss JA, Snively BM. Heritability of serum iron measures in the hemochromatosis and iron overload screening (HEIRS) family study. Am J Hematol. 2010 Feb; 85(2):101-5. PMID: 20095037.
      View in: PubMed
    23. Adams P, Barton JC, McLaren G, Acton RT, Speechley M, McLaren CE, Reboussin DM, Leiendecker-Foster C, Harris EL, Snively BM, Vogt T, Sholinsky P, Thomson E, Dawkins FW, Gordeuk VR, Eckfeldt JH. Screening for iron overload: lessons from the hemochromatosis and iron overload screening (HEIRS) study. Can J Gastroenterol. 2009 Nov; 23(11):769-72. PMID: 19893773; PMCID: PMC2777090.
    24. Pinto JT, Khomenko T, Szabo S, McLaren G, Denton TT, Krasnikov BF, Jeitner TM, Cooper AJ. Measurement of sulfur-containing compounds involved in the metabolism and transport of cysteamine and cystamine. Regional differences in cerebral metabolism. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 15; 877(28):3434-41. PMID: 19523884; PMCID: PMC2752955.
    25. Piazza G, Rosenbaum EJ, Pendergast W, Jacobson JO, Pendleton RC, McLaren G, Elliott CG, Stevens SM, Patton WF, Dabbagh O, Paterno MD, Catapane E, Li Z, Goldhaber SZ. Physician alerts to prevent symptomatic venous thromboembolism in hospitalized patients. Circulation. 2009 Apr 28; 119(16):2196-201. PMID: 19364975; PMCID: PMC2901546.
    26. Khomenko T, Szabo S, Deng X, Ishikawa H, Anderson GJ, McLaren G. Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. Am J Physiol Gastrointest Liver Physiol. 2009 Jun; 296(6):G1277-86. PMID: 19342511; PMCID: PMC3834006.
    27. Anderson GJ, Frazer DM, McLaren G. Iron absorption and metabolism. Curr Opin Gastroenterol. 2009 Mar; 25(2):129-35. PMID: 19528880.
      View in: PubMed
    28. Wang X, Leiendecker-Foster C, Acton RT, Barton JC, McLaren CE, McLaren G, Gordeuk VR, Eckfeldt JH. Heme carrier protein 1 (HCP1) genetic variants in the Hemochromatosis and Iron Overload Screening (HEIRS) Study participants. Blood Cells Mol Dis. 2009 Mar-Apr; 42(2):150-4. PMID: 19176287.
      View in: PubMed
    29. Adams PC, Pankow JS, Barton JC, Acton RT, Leiendecker-Foster C, McLaren G, Speechley M, Eckfeldt JH. HFE C282Y homozygosity is associated with lower total and low-density lipoprotein cholesterol: The hemochromatosis and iron overload screening study. Circ Cardiovasc Genet. 2009 Feb; 2(1):34-7. PMID: 20031565.
      View in: PubMed
    30. McLaren G, Gordeuk VR. Hereditary hemochromatosis: insights from the Hemochromatosis and Iron Overload Screening (HEIRS) Study. Hematology Am Soc Hematol Educ Program. 2009; 195-206. PMID: 20008199; PMCID: PMC3829617.
    31. McLaren G, McLaren CE, Adams PC, Barton JC, Reboussin DM, Gordeuk VR, Acton RT, Harris EL, Speechley MR, Sholinsky P, Dawkins FW, Snively BM, Vogt TM, Eckfeldt JH. Clinical manifestations of hemochromatosis in HFE C282Y homozygotes identified by screening. Can J Gastroenterol. 2008 Nov; 22(11):923-30. PMID: 19018338; PMCID: PMC2661195.
    32. Gordeuk VR, Reboussin DM, McLaren CE, Barton JC, Acton RT, McLaren G, Harris EL, Reiss JA, Adams PC, Speechley M, Phatak PD, Sholinsky P, Eckfeldt JH, Chen WP, Passmore L, Dawkins FW. Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population. Am J Hematol. 2008 Aug; 83(8):618-26. PMID: 18429050; PMCID: PMC3773165.
    33. Acton RT, Barton JC, Passmore LV, Adams PC, McLaren G, Leiendecker-Foster C, Speechley MR, Harris EL, Castro O, Reiss JA, Snively BM, Harrison BW, McLaren CE. Accuracy of family history of hemochromatosis or iron overload: the hemochromatosis and iron overload screening study. Clin Gastroenterol Hepatol. 2008 Aug; 6(8):934-8. PMID: 18585964; PMCID: PMC3779058.
    34. Barton JC, Acton RT, Leiendecker-Foster C, Lovato L, Adams PC, Eckfeldt JH, McLaren CE, Reiss JA, McLaren G, Reboussin DM, Gordeuk VR, Speechley MR, Press RD, Dawkins FW. Characteristics of participants with self-reported hemochromatosis or iron overload at HEIRS study initial screening. Am J Hematol. 2008 Feb; 83(2):126-32. PMID: 17726683; PMCID: PMC3773364.
    35. Adams PC, Reboussin DM, Press RD, Barton JC, Acton RT, Moses GC, Leiendecker-Foster C, McLaren G, Dawkins FW, Gordeuk VR, Lovato L, Eckfeldt JH. Biological variability of transferrin saturation and unsaturated iron-binding capacity. Am J Med. 2007 Nov; 120(11):999.e1-7. PMID: 17976429.
      View in: PubMed
    36. Harris EL, McLaren CE, Reboussin DM, Gordeuk VR, Barton JC, Acton RT, McLaren G, Vogt TM, Snively BM, Leiendecker-Foster C, Holup JL, Passmore LV, Eckfeldt JH, Lin E, Adams PC. Serum ferritin and transferrin saturation in Asians and Pacific Islanders. Arch Intern Med. 2007 Apr 09; 167(7):722-6. PMID: 17420432.
      View in: PubMed
    37. Dawkins FW, Gordeuk VR, Snively BM, Lovato L, Barton JC, Acton RT, McLaren G, Leiendecker-Foster C, McLaren CE, Adams PC, Speechley M, Harris EL, Jackson S, Thomson EJ. African Americans at risk for increased iron stores or liver disease. Am J Med. 2007 Aug; 120(8):734.e1-9. PMID: 17679134.
      View in: PubMed
    38. Rivers CA, Barton JC, Gordeuk VR, Acton RT, Speechley MR, Snively BM, Leiendecker-Foster C, Press RD, Adams PC, McLaren G, Dawkins FW, McLaren CE, Reboussin DM. Association of ferroportin Q248H polymorphism with elevated levels of serum ferritin in African Americans in the Hemochromatosis and Iron Overload Screening (HEIRS) Study. Blood Cells Mol Dis. 2007 May-Jun; 38(3):247-52. PMID: 17276706.
      View in: PubMed
    39. Steiner M, Leiendecker-Foster C, McLaren G, Snively BM, McLaren CE, Adams PC, Eckfeldt JH. Hemochromatosis (HFE) gene splice site mutation IVS5+1 G/A in North American Vietnamese with and without phenotypic evidence of iron overload. Transl Res. 2007 Feb; 149(2):92-5. PMID: 17240320.
      View in: PubMed
    40. Barton JC, Acton RT, Leiendecker-Foster C, Lovato L, Adams PC, McLaren G, Eckfeldt JH, McLaren CE, Reboussin DM, Gordeuk VR, Speechley MR, Reiss JA, Press RD, Dawkins FW. HFE C282Y homozygotes aged 25-29 years at HEIRS Study initial screening. Genet Test. 2007; 11(3):269-75. PMID: 17949288.
      View in: PubMed
    41. McLaren CE, Li KT, McLaren G, Gordeuk VR, Snively BM, Reboussin DM, Barton JC, Acton RT, Dawkins FW, Harris EL, Eckfeldt JH, Moses GC, Adams PC. Mixture models of serum iron measures in population screening for hemochromatosis and iron overload. Transl Res. 2006 Oct; 148(4):196-206. PMID: 17002922.
      View in: PubMed
    42. Acton RT, Barton JC, Passmore LV, Adams PC, Speechley MR, Dawkins FW, Sholinsky P, Reboussin DM, McLaren G, Harris EL, Bent TC, Vogt TM, Castro O. Relationships of serum ferritin, transferrin saturation, and HFE mutations and self-reported diabetes in the Hemochromatosis and Iron Overload Screening (HEIRS) study. Diabetes Care. 2006 Sep; 29(9):2084-9. PMID: 16936157.
      View in: PubMed
    43. Adams PC, Passmore L, Chakrabarti S, Reboussin DM, Acton RT, Barton JC, McLaren G, Eckfeldt JH, Dawkins FW, Gordeuk VR, Harris EL, Leiendecker-Foster C, Gossman E, Sholinsky P. Liver diseases in the hemochromatosis and iron overload screening study. Clin Gastroenterol Hepatol. 2006 Jul; 4(7):918-23; quiz 807. PMID: 16797244.
      View in: PubMed
    44. Acton RT, Barton JC, Snively BM, McLaren CE, Adams PC, Harris EL, Speechley MR, McLaren G, Dawkins FW, Leiendecker-Foster C, Holup JL, Balasubramanyam A. Geographic and racial/ethnic differences in HFE mutation frequencies in the Hemochromatosis and Iron Overload Screening (HEIRS) Study. Ethn Dis. 2006; 16(4):815-21. PMID: 17061732.
      View in: PubMed
    45. Wilkins SJ, Frazer DM, Millard KN, McLaren G, Anderson GJ. Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression. Blood. 2006 Feb 15; 107(4):1659-64. PMID: 16239432; PMCID: PMC1895407.
    46. Hall MA, McEwen JE, Barton JC, Walker AP, Howe EG, Reiss JA, Power TE, Ellis SD, Tucker DC, Harrison BW, McLaren G, Ruggiero A, Thomson EJ. Concerns in a primary care population about genetic discrimination by insurers. Genet Med. 2005 May-Jun; 7(5):311-6. PMID: 15915082.
      View in: PubMed
    47. Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren G, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med. 2005 Apr 28; 352(17):1769-78. PMID: 15858186.
      View in: PubMed
    48. Adams PC, Reboussin DM, Leiendecker-Foster C, Moses GC, McLaren G, McLaren CE, Dawkins FW, Kasvosve I, Acton RT, Barton JC, Zaccaro D, Harris EL, Press R, Chang H, Eckfeldt JH. Comparison of the unsaturated iron-binding capacity with transferrin saturation as a screening test to detect C282Y homozygotes for hemochromatosis in 101,168 participants in the hemochromatosis and iron overload screening (HEIRS) study. Clin Chem. 2005 Jun; 51(6):1048-52. PMID: 15833784.
      View in: PubMed
    49. Barton JC, Acton RT, Dawkins FW, Adams PC, Lovato L, Leiendecker-Foster C, McLaren CE, Reboussin DM, Speechley MR, Gordeuk VR, McLaren G, Sholinsky P, Harris EL. Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in whites and blacks in the Hemochromatosis and Iron Overload Screening Study. Genet Test. 2005; 9(3):231-41. PMID: 16225403.
      View in: PubMed
    50. McLaren CE, Barton JC, Adams PC, Harris EL, Acton RT, Press N, Reboussin DM, McLaren G, Sholinsky P, Walker AP, Gordeuk VR, Leiendecker-Foster C, Dawkins FW, Eckfeldt JH, Mellen BG, Speechley M, Thomson E. Hemochromatosis and Iron Overload Screening (HEIRS) study design for an evaluation of 100,000 primary care-based adults. Am J Med Sci. 2003 Feb; 325(2):53-62. PMID: 12589228.
      View in: PubMed
    Gordon's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _