Xiaolin Zi

Title(s)Professor, Urology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-8316, (714) 456-6088
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    Collapse Research 
    Collapse Research Activities and Funding
    The NEDD8 pathway mediated Skp2 degradation in chemoprevention by FKA
    NIH R01CA193967Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Phase 1 Bioassay-guided Trial of Lycopene and Docetaxel for Prostate Cancer
    NIH R21CA166839Sep 1, 2013 - Aug 31, 2016
    Role: Co-Principal Investigator
    Rhodiola Rosea Extracts, Salidroside and Bladder Cancer Chemoprevention
    NIH R21CA152804Mar 8, 2011 - Feb 28, 2014
    Role: Principal Investigator
    Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    NIH R01CA122558Dec 10, 2007 - Nov 30, 2013
    Role: Principal Investigator
    Lycopene &Docetaxel in Prostate Cancer: An IGF-I Receptor Targeting Approach
    NIH R21CA129793Sep 14, 2007 - Aug 31, 2010
    Role: Principal Investigator
    Kava extract, Flavokawains and Bladder Cancer Prevention
    NIH R21CA109428Jul 13, 2004 - Jun 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mediator kinase inhibition reverses castration resistance of advanced prostate cancer. J Clin Invest. 2024 Mar 28. Li J, Hilimire TA, Yueying L, Wang L, Liang J, Gyorffy B, Sikirzhytski V, Ji H, Zhang L, Cheng C, Ding X, Kerr KR, Dowling CE, Chumanevich AA, Mack ZT, Schools GP, Lim CU, Ellis L, Zi X, Porter DC, Broude EV, McInnes C, Wilding G, Lilly MB, Roninson IB, Chen M. PMID: 38546787.
      View in: PubMed   Mentions:    Fields:    
    2. A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients. Clin Transl Med. 2024 Mar; 14(3):e1627. Lilly MB, Wu C, Ke Y, Chen WP, Soloff AC, Armeson K, Yokoyama NN, Li X, Song L, Yuan Y, McLaren CE, Zi X. PMID: 38515274; PMCID: PMC10958125.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsCTClinical Trials
    3. ATPase copper transporting beta (ATP7B) is a novel target for improving the therapeutic efficacy of docetaxel by disulfiram/copper in human prostate cancer. Mol Cancer Ther. 2024 Feb 28. Song L, Nguyen V, Xie J, JIa S, Chang CJ, Uchio E, Zi X. PMID: 38417139.
      View in: PubMed   Mentions:    Fields:    
    4. Targeted inhibition of SCFSKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma. Oncogene. 2024 Mar; 43(13):962-975. Wang J, Ferrena A, Zhang R, Singh S, Viscarret V, Al-Harden W, Aldahamsheh O, Borjihan H, Singla A, Yaguare S, Tingling J, Zi X, Lo Y, Gorlick R, Schwartz EL, Zhao H, Yang R, Geller DS, Zheng D, Hoang BH. PMID: 38355807; PMCID: PMC10959747.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. Dysfunction of the aging female mouse urethra is associated with striated muscle loss and increased fibrosis: an initial report. Am J Clin Exp Urol. 2023; 11(6):516-529. Sadeghi Z, Wu YX, Vu A, Song L, Phan W, Kim J, Keast JR, Balis U, DeLancey J, Villalta SA, Zi X. PMID: 38148939; PMCID: PMC10749384.
      View in: PubMed   Mentions:
    6. Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced anti-tumor effects with ferroptosis inducers in NSCLC. Cell Death Dis. 2023 11 03; 14(11):716. Du L, Yang H, Ren Y, Ding Y, Xu Y, Zi X, Liu H, He P. PMID: 37923740; PMCID: PMC10624898.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer. Curr Pharmacol Rep. 2023 Oct; 9(5):261-274. Kishore C, Zi X. PMID: 37994344; PMCID: PMC10664806.
      View in: PubMed   Mentions:
    8. The Potent Anti-Tumor Effects of Rhodiola Drinking Are Associated with the Inhibition of the mTOR Pathway and Modification of Tumor Metabolism in the UPII-Mutant Ha-Ras Model. Cancers (Basel). 2023 Jun 07; 15(12). Liu Z, Yokoyama NN, Song L, Xie J, Sadeghi Z, Wu YX, Yee S, Wu XR, Wang B, Uchio E, Zi X. PMID: 37370698; PMCID: PMC10296277.
      View in: PubMed   Mentions: 1  
    9. Kawain Inhibits Urinary Bladder Carcinogenesis through Epigenetic Inhibition of LSD1 and Upregulation of H3K4 Methylation. Biomolecules. 2023 03 13; 13(3). Xu X, Tian X, Song L, Xie J, Liao JC, Meeks JJ, Wu XR, Gin GE, Wang B, Uchio E, Zi X. PMID: 36979456; PMCID: PMC10046577.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Comprehensive analysis of cuproptosis-related genes on bladder cancer prognosis, tumor microenvironment invasion, and drug sensitivity. Front Oncol. 2023; 13:1116305. Wang H, Li J, Zi X, Yuan X. PMID: 36895470; PMCID: PMC9989218.
      View in: PubMed   Mentions:
    11. Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism. Molecules. 2023 Feb 09; 28(4). Liu Z, Song L, Xie J, Wu XR, Gin GE, Wang B, Uchio E, Zi X. PMID: 36838656; PMCID: PMC9966944.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    12. Prostate cancer immunotherapy: a review of recent advancements with novel treatment methods and efficacy. Am J Clin Exp Urol. 2022; 10(4):210-233. Wang I, Song L, Wang BY, Rezazadeh Kalebasty A, Uchio E, Zi X. PMID: 36051616; PMCID: PMC9428569.
      View in: PubMed   Mentions: 15  
    13. Flavokawain A Reduces Tumor-Initiating Properties and Stemness of Prostate Cancer. Front Oncol. 2022; 12:943846. Song L, Mino M, Yamak J, Nguyen V, Lopez D, Pham V, Fazelpour A, Le V, Fu D, Tippin M, Uchio E, Zi X. PMID: 35912174; PMCID: PMC9326116.
      View in: PubMed   Mentions: 3  
    14. Risk factors for asthma in patients with allergic rhinitis in eastern China. Am J Otolaryngol. 2022 May-Jun; 43(3):103426. Zhao L, Yang Y, Zang YR, Zhang QQ, Liang X, Yuan GM, Jin P, Zi XX, Yu KN, Zhang HL, Shi L. PMID: 35460970.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    15. Chemoprevention of Urothelial Cell Carcinoma Tumorigenesis by Dietary Flavokawain A in UPII-Mutant Ha-ras Transgenic Mice. Pharmaceutics. 2022 Feb 24; 14(3). Liu Z, Song L, Xie J, Simoneau AR, Uchio E, Zi X. PMID: 35335874; PMCID: PMC8955676.
      View in: PubMed   Mentions: 8  
    16. A phase II study of docetaxel plus lycopene in metastatic castrate resistant prostate cancer. Biomed Pharmacother. 2021 Nov; 143:112226. Zhuang E, Uchio E, Lilly M, Zi X, Fruehauf JP. PMID: 34649352; PMCID: PMC9886492.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    17. Kava root extracts hinder prostate cancer development and tumorigenesis by involvement of dual inhibition of MAO-A and LSD1. J Transl Genet Genom. 2021; 5:163-172. Li X, Song L, Xu S, Tippin M, Meng S, Xie J, Uchio E, Zi X. PMID: 34368644; PMCID: PMC8341175.
      View in: PubMed   Mentions: 4  
    18. A Novel Ferroptosis Related Gene Signature for Prognosis Prediction in Patients With Colon Cancer. Front Oncol. 2021; 11:654076. Nie J, Shan D, Li S, Zhang S, Zi X, Xing F, Shi J, Liu C, Wang T, Sun X, Zhang Q, Zhou M, Luo S, Meng H, Zhang Y, Zheng T. PMID: 34046350; PMCID: PMC8144717.
      View in: PubMed   Mentions: 27  
    19. The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma. Ann N Y Acad Sci. 2021 04; 1490(1):90-104. Wang J, Aldahamsheh O, Ferrena A, Borjihan H, Singla A, Yaguare S, Singh S, Viscarret V, Tingling J, Zi X, Lo Y, Gorlick R, Zheng D, Schwartz EL, Zhao H, Yang R, Geller DS, Hoang BH. PMID: 33594717; PMCID: PMC8632790.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. Skp2 depletion reduces tumor-initiating properties and promotes apoptosis in synovial sarcoma. Transl Oncol. 2020 Oct; 13(10):100809. Wang J, Sato K, O'Donnell E, Singla A, Yaguare S, Aldahamsheh O, Batko B, Borjihan H, Tingling J, Zhang J, Weiser DA, Loeb DM, Gorlick R, Schwartz EL, Yang R, Zi X, Zhao H, Geller DS, Hoang BH. PMID: 32623326; PMCID: PMC7334610.
      View in: PubMed   Mentions: 8  
    21. Severity of Rhinosinusitis: Comparison Between Visual Analog Scale Given by Patients and Otorhinolaryngologists. Am J Rhinol Allergy. 2020 Nov; 34(6):734-741. Zhao L, Yu KN, Tan JL, Zhang HL, Jin P, Zi XX, Tu YY, Li T, Zhou XM, Shi L, Wang Y. PMID: 32403940.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Discovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo. Eur J Med Chem. 2020 Apr 15; 192:112153. Fu DJ, Song J, Zhu T, Pang XJ, Wang SH, Zhang YB, Wu BW, Wang JW, Zi X, Zhang SY, Liu HM. PMID: 32135407.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    23. Gartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression, and autophagy. Mol Carcinog. 2020 02; 59(2):193-201. Pham V, Rendon R, Le VX, Tippin M, Fu DJ, Le TH, Miller M, Agredano E, Cedano J, Zi X. PMID: 31782573; PMCID: PMC6946862.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    24. Expression and prognostic utility of PD-L1 in patients with squamous cell carcinoma of the bladder. Urol Oncol. 2019 07; 37(7):478-484. Owyong M, Lotan Y, Kapur P, Panwar V, McKenzie T, Lee TK, Zi X, Martin JW, Mosbah A, Abol-Enein H, Ghoneim M, Youssef RF. PMID: 30910351.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation. Cell Commun Signal. 2019 03 18; 17(1):25. Li X, Pham V, Tippin M, Fu D, Rendon R, Song L, Uchio E, Hoang BH, Zi X. PMID: 30885218; PMCID: PMC6423783.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. LncRNA SNHG1 alleviates OGD induced injury in BMEC via miR-338/HIF-1α axis. Brain Res. 2019 07 01; 1714:174-181. Yang X, Zi XH. PMID: 30414401.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    27. Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma. Sci Rep. 2018 09 24; 8(1):14294. Zhang Y, Zvi YS, Batko B, Zaphiros N, O'Donnell EF, Wang J, Sato K, Yang R, Geller DS, Koirala P, Zhang W, Du X, Piperdi S, Liu Y, Zheng D, Roth M, Gill J, Zhang J, Ren T, Gorlick R, Zi X, Hoang BH. PMID: 30250282; PMCID: PMC6155331.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    28. Prevention of prostate cancer by natural product MDM2 inhibitor GS25: in vitro and in vivo activities and molecular mechanisms. Carcinogenesis. 2018 07 30; 39(8):1026-1036. Wang W, Qin JJ, Li X, Tao G, Wang Q, Wu X, Zhou J, Zi X, Zhang R. PMID: 29762656; PMCID: PMC6067121.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    29. Bioactive heterocycles containing a 3,4,5-trimethoxyphenyl fragment exerting potent antiproliferative activity through microtubule destabilization. Eur J Med Chem. 2018 Sep 05; 157:50-61. Fu DJ, Yang JJ, Li P, Hou YH, Huang SN, Tippin MA, Pham V, Song L, Zi X, Xue WL, Zhang LR, Zhang SY. PMID: 30075402.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    30. Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen. Front Pharmacol. 2017; 8:917. Qin JJ, Li X, Wang W, Zi X, Zhang R. PMID: 29311926; PMCID: PMC5735069.
      View in: PubMed   Mentions: 20  
    31. Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway. J Biomed Res. 2017 Sep 26; 31(5):408-418. Liu Z, Ha US, Yu K, Wu C, Yokoyama N, Zi X. PMID: 28959001; PMCID: PMC5706433.
      View in: PubMed   Mentions: 9  
    32. Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Curr Pharmacol Rep. 2017 Dec; 3(6):384-395. Li Y, Pham V, Bui M, Song L, Wu C, Walia A, Uchio E, Smith-Liu F, Zi X. PMID: 30393593; PMCID: PMC6208354.
      View in: PubMed   Mentions: 26  
    33. A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells. Sci Rep. 2017 08 29; 7(1):9873. Zhang S, Li T, Zhang L, Wang X, Dong H, Li L, Fu D, Li Y, Zi X, Liu HM, Zhang Y, Xu H, Jin CY. PMID: 28852176; PMCID: PMC5575266.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    34. Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin. Molecules. 2017 Mar 14; 22(3). Jandial DD, Krill LS, Chen L, Wu C, Ke Y, Xie J, Hoang BH, Zi X. PMID: 28335434; PMCID: PMC5547191.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    35. Mutant presenilin2 promotes apoptosis through the p53/miR-34a axis in neuronal cells. Brain Res. 2017 05 01; 1662:57-64. Li LH, Tu QY, Deng XH, Xia J, Hou DR, Guo K, Zi XH. PMID: 28189560.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    36. Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species. Oncotarget. 2016 Dec 27; 7(52):86211-86224. Ma YC, Ke Y, Zi X, Zhao F, Yuan L, Zhu YL, Fan XX, Zhao NM, Li QY, Qin YH, Liu HM. PMID: 27863415; PMCID: PMC5349908.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    37. A new brominated chalcone derivative suppresses the growth of gastric cancer cells in vitro and in vivo involving ROS mediated up-regulation of DR5 and 4 expression and apoptosis. Toxicol Appl Pharmacol. 2016 10 15; 309:77-86. Zhang S, Li T, Zhang Y, Xu H, Li Y, Zi X, Yu H, Li J, Jin CY, Liu HM. PMID: 27594528; PMCID: PMC5507202.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    38. Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growth. Sci Rep. 2016 09 01; 6:32582. Chen L, Xia G, Qiu F, Wu C, Denmon AP, Zi X. PMID: 27581364; PMCID: PMC5007653.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. Effect of perineoplasm perinephric adipose tissues on migration of clear cell renal cell carcinoma cells: a potential role of WNT signaling. Oncotarget. 2016 Aug 16; 7(33):53277-53288. Zi X, Lusch A, Blair CA, Okhunov Z, Yokoyama NN, Liu S, Baker M, Huynh V, Landman J. PMID: 27409168; PMCID: PMC5288185.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    40. New withanolides with TRAIL-sensitizing effect from Physalis pubescens L. RSC Adv. 2016; 6(58):52925-52936. Chen LX, Xia GY, He H, Huang J, Qiu F, Zi XL. PMID: 27822364; PMCID: PMC5095689.
      View in: PubMed   Mentions: 6  
    41. High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum. Mol Cancer Ther. 2016 Mar; 15(3):430-8. Liu Z, Yokoyama NN, Blair CA, Li X, Avizonis D, Wu XR, Uchio E, Youssef R, McClelland M, Pollak M, Zi X. PMID: 26921394; PMCID: PMC4783238.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    42. Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model. Oncotarget. 2015 Dec 08; 6(39):41809-24. Li X, Yokoyama NN, Zhang S, Ding L, Liu HM, Lilly MB, Mercola D, Zi X. PMID: 26497688; PMCID: PMC4747190.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    43. Aerosol transfer of bladder urothelial and smooth muscle cells onto demucosalized colonic segments for bladder augmentation: in vivo, long term, and functional pilot study. J Pediatr Urol. 2015 Oct; 11(5):260.e1-6. Hidas G, Lee HJ, Bahoric A, Kelly MS, Watts B, Liu Z, Saharti S, Lusch A, Alamsahebpour A, Kerbl D, Truong H, Zi X, Khoury AE. PMID: 26022502; PMCID: PMC4623943.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    44. Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma. Mol Cancer. 2015 Apr 17; 14:86. Ji T, Guo Y, Kim K, McQueen P, Ghaffar S, Christ A, Lin C, Eskander R, Zi X, Hoang BH. PMID: 25890345; PMCID: PMC4411772.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    45. When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow? Curr Pharmacol Rep. 2015 Dec 01; 1(6):420-433. Yokoyama NN, Denmon A, Uchio EM, Jordan M, Mercola D, Zi X. PMID: 26756023; PMCID: PMC4705552.
      View in: PubMed   Mentions: 7  
    46. Jaridonin-induced G2/M phase arrest in human esophageal cancer cells is caused by reactive oxygen species-dependent Cdc2-tyr15 phosphorylation via ATM-Chk1/2-Cdc25C pathway. Toxicol Appl Pharmacol. 2015 Jan 15; 282(2):227-36. Ma YC, Su N, Shi XJ, Zhao W, Ke Y, Zi X, Zhao NM, Qin YH, Zhao HW, Liu HM. PMID: 25450480; PMCID: PMC4721529.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    47. Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-β and IGF signaling. Biomed Res Int. 2014; 2014:502093. Lee C, Jia Z, Rahmatpanah F, Zhang Q, Zi X, McClelland M, Mercola D. PMID: 25089270; PMCID: PMC4095744.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    48. Wnt signaling in castration-resistant prostate cancer: implications for therapy. Am J Clin Exp Urol. 2014 Apr 15; 2(1):27-44. Yokoyama NN, Shao S, Hoang BH, Mercola D, Zi X. PMID: 25143959; PMCID: PMC4219296.
      View in: PubMed   Mentions: 49  
    49. Dietary feeding of Flavokawain A, a Kava chalcone, exhibits a satisfactory safety profile and its association with enhancement of phase II enzymes in mice. Toxicol Rep. 2014; 1:2-11. Li X, Xu X, Ji T, Liu Z, Gu M, Hoang BH, Zi X. PMID: 25379458; PMCID: PMC4219529.
      View in: PubMed   Mentions: 11  
    50. Molecular targeted approaches to cancer therapy and prevention using chalcones. Curr Cancer Drug Targets. 2014; 14(2):181-200. Jandial DD, Blair CA, Zhang S, Krill LS, Zhang YB, Zi X. PMID: 24467530; PMCID: PMC4107204.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    51. Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration. J Med Chem. 2013 Nov 14; 56(21):8543-60. Zheng YC, Duan YC, Ma JL, Xu RM, Zi X, Lv WL, Wang MM, Ye XW, Zhu S, Mobley D, Zhu YY, Wang JW, Li JF, Wang ZR, Zhao W, Liu HM. PMID: 24131029; PMCID: PMC3881423.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    52. Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model. Cancer Prev Res (Phila). 2013 Dec; 6(12):1365-75. Liu Z, Xu X, Li X, Liu S, Simoneau AR, He F, Wu XR, Zi X. PMID: 24121102; PMCID: PMC3873822.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    53. Jaridonin, a novel ent-kaurene diterpenoid from Isodon rubescens, inducing apoptosis via production of reactive oxygen species in esophageal cancer cells. Curr Cancer Drug Targets. 2013 Jul; 13(6):611-24. Ma YC, Ke Y, Zi X, Zhao W, Shi XJ, Liu HM. PMID: 23597192; PMCID: PMC3750090.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    54. Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis. Mol Cancer. 2013 Jun 10; 12:55. Ji T, Lin C, Krill LS, Eskander R, Guo Y, Zi X, Hoang BH. PMID: 23764122; PMCID: PMC3681603.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    55. Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention. Curr Cancer Drug Targets. 2013 Jun; 13(5):558-79. Tian X, Zhang S, Liu HM, Zhang YB, Blair CA, Mercola D, Sassone-Corsi P, Zi X. PMID: 23713993; PMCID: PMC3703250.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    56. Anti-cancer molecular targets of natural products. Curr Cancer Drug Targets. 2013 Jun; 13(5):485. Zi X, Zhang R. PMID: 23802843.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    57. Dkk-3, a secreted wnt antagonist, suppresses tumorigenic potential and pulmonary metastasis in osteosarcoma. Sarcoma. 2013; 2013:147541. Lin CH, Guo Y, Ghaffar S, McQueen P, Pourmorady J, Christ A, Rooney K, Ji T, Eskander R, Zi X, Hoang BH. PMID: 23476112; PMCID: PMC3582188.
      View in: PubMed   Mentions: 30  
    58. The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines. Nutr Cancer. 2013; 65 Suppl 1:68-77. Liu Z, Antalek M, Nguyen L, Li X, Tian X, Le A, Zi X. PMID: 23682785; PMCID: PMC3671488.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    59. Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line. J Obstet Gynaecol Res. 2012 Aug; 38(8):1086-94. Eskander RN, Randall LM, Sakai T, Guo Y, Hoang B, Zi X. PMID: 22540374; PMCID: PMC3405181.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    60. Expression of the Wnt antagonist Dickkopf-3 is associated with prognostic clinicopathologic characteristics and impairs proliferation and invasion in endometrial cancer. Gynecol Oncol. 2012 Aug; 126(2):259-67. Dellinger TH, Planutis K, Jandial DD, Eskander RN, Martinez ME, Zi X, Monk BJ, Holcombe RF. PMID: 22555103; PMCID: PMC3688285.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    61. Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice. PLoS One. 2012; 7(2):e31213. Li X, Liu Z, Xu X, Blair CA, Sun Z, Xie J, Lilly MB, Zi X. PMID: 22347450; PMCID: PMC3276576.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    62. Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. J Orthop Res. 2012 Jul; 30(7):1045-50. Sakai T, Eskander RN, Guo Y, Kim KJ, Mefford J, Hopkins J, Bhatia NN, Zi X, Hoang BH. PMID: 22213202; PMCID: PMC3685290.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    63. Potential molecular targeting of splice variants for cancer treatment. Indian J Exp Biol. 2011 Nov; 49(11):836-9. Blair CA, Zi X. PMID: 22126014; PMCID: PMC3253385.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    64. The Wnt signaling pathway: implications for therapy in osteosarcoma. Expert Rev Anticancer Ther. 2011 Aug; 11(8):1223-32. McQueen P, Ghaffar S, Guo Y, Rubin EM, Zi X, Hoang BH. PMID: 21916576.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    65. Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Mol Carcinog. 2012 Mar; 51(3):257-67. Liu Z, Li X, Simoneau AR, Jafari M, Zi X. PMID: 21520297; PMCID: PMC3144985.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    66. Lycopene enhances docetaxel's effect in castration-resistant prostate cancer associated with insulin-like growth factor I receptor levels. Neoplasia. 2011 Feb; 13(2):108-19. Tang Y, Parmakhtiar B, Simoneau AR, Xie J, Fruehauf J, Lilly M, Zi X. PMID: 21403837; PMCID: PMC3033590.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    67. Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth. Int J Cancer. 2010 Oct 15; 127(8):1758-68. Tang Y, Li X, Liu Z, Simoneau AR, Xie J, Zi X. PMID: 20112340; PMCID: PMC2888737.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    68. The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Mol Cancer. 2010 Jun 23; 9:162. Yee DS, Tang Y, Li X, Liu Z, Guo Y, Ghaffar S, McQueen P, Atreya D, Xie J, Simoneau AR, Hoang BH, Zi X. PMID: 20573255; PMCID: PMC2907330.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    69. Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol Cancer Ther. 2010 Mar; 9(3):731-41. Rubin EM, Guo Y, Tu K, Xie J, Zi X, Hoang BH. PMID: 20197388; PMCID: PMC2837364.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    70. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther. 2009 Feb; 8(2):458-68. Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Hoang BH, Zi X. PMID: 19174556; PMCID: PMC2768341.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    71. Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53. Cancer Prev Res (Phila). 2008 Nov; 1(6):439-51. Tang Y, Simoneau AR, Xie J, Shahandeh B, Zi X. PMID: 19138991; PMCID: PMC2830727.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    72. Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model. Clin Orthop Relat Res. 2008 Sep; 466(9):2039-45. Guo Y, Rubin EM, Xie J, Zi X, Hoang BH. PMID: 18566875; PMCID: PMC2493003.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    73. Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res. 2008 May 01; 68(9):3350-60. Guo Y, Xie J, Rubin E, Tang YX, Lin F, Zi X, Hoang BH. PMID: 18451162; PMCID: PMC2824245.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    74. Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. J Orthop Res. 2007 Jul; 25(7):964-71. Guo Y, Zi X, Koontz Z, Kim A, Xie J, Gorlick R, Holcombe RF, Hoang BH. PMID: 17318900.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    75. [Study on aggregate formation mechanism of HSPB8 gene mutation resulting in CMT2L]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Dec; 23(6):601-4. Zhang RX, Tang BS, Zi XH, Xia K, Pan Q, Zhang FF, Li SJ, Zhao GH, Guo K. PMID: 17160934.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    76. Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res. 2005 Nov 01; 65(21):9762-70. Zi X, Guo Y, Simoneau AR, Hope C, Xie J, Holcombe RF, Hoang BH. PMID: 16266997.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    77. [Effects of sodium aescinate on bcl-2 and caspase-3 expression and apoptosis after focal cerebral ischemia reperfusion injury in rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Jun; 30(3):261-5, 275. Fan XJ, Guo K, Xiao B, Zi XH, Song Z. PMID: 16045009.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    78. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res. 2005 Apr 15; 65(8):3479-86. Zi X, Simoneau AR. PMID: 15833884.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    79. [Combining exchange of cerebrospinal fluid with small dose of urokinase injection for subarachnoid hemorrhage]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Apr; 30(2):217-20. Li YH, Guo K, Zi XH, Song Z. PMID: 15898439.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    80. Bioactive suture: a novel immunotherapy for head and neck cancer. Clin Cancer Res. 2004 Oct 15; 10(20):7088-99. Shibuya TY, Kim S, Nguyen K, Do J, McLaren CE, Li KT, Chen WP, Parikh P, Wadhwa A, Zi X, Chen VY, Wong HS, Armstrong WB, Yoo GH. PMID: 15501989.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsCTClinical Trials
    81. Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells. Int J Cancer. 2004 Jan 20; 108(3):334-41. Lu Y, Zi X, Pollak M. PMID: 14648698.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    82. Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells. Biochem Biophys Res Commun. 2004 Jan 16; 313(3):709-15. Lu Y, Zi X, Zhao Y, Pollak M. PMID: 14697248.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
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