Zi, Xiaolin

InstitutionUniversity of California, Irvine
Address1001 Health Sciences Road
CA 92697-3950
Phone(714) 456-8316, (714) 456-6088
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    Collapse Research 
    Collapse Research Activities and Funding
    The NEDD8 pathway mediated Skp2 degradation in chemoprevention by FKA
    NIH/NCI R01CA193967Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Phase 1 Bioassay-guided Trial of Lycopene and Docetaxel for Prostate Cancer
    NIH/NCI R21CA166839Sep 1, 2013 - Aug 31, 2015
    Role: Co-Principal Investigator
    Rhodiola Rosea Extracts, Salidroside and Bladder Cancer Chemoprevention
    NIH/NCI R21CA152804Mar 8, 2011 - Feb 28, 2014
    Role: Principal Investigator
    Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    NIH/NCI R01CA122558Dec 10, 2007 - Nov 30, 2013
    Role: Principal Investigator
    Lycopene &Docetaxel in Prostate Cancer: An IGF-I Receptor Targeting Approach
    NIH/NCI R21CA129793Sep 14, 2007 - Aug 31, 2010
    Role: Principal Investigator
    Kava extract, Flavokawains and Bladder Cancer Prevention
    NIH/NCI R21CA109428Jul 13, 2004 - Jun 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fu DJ, Yang JJ, Li P, Hou YH, Huang SN, Tippin MA, Pham V, Song L, Zi X, Xue WL, Zhang LR, Zhang SY. Bioactive heterocycles containing a 3,4,5-trimethoxyphenyl fragment exerting potent antiproliferative activity through microtubule destabilization. Eur J Med Chem. 2018 Jul 29; 157:50-61. PMID: 30075402.
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    2. Qin JJ, Li X, Wang W, Zi X, Zhang R. Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen. Front Pharmacol. 2017; 8:917. PMID: 29311926.
      View in: PubMed
    3. Liu Z, Ha US, Yu K, Wu C, Yokoyama N, Zi X. Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway. J Biomed Res. 2017 Sep 26; 31(5):408-418. PMID: 28959001.
      View in: PubMed
    4. Zhang S, Li T, Zhang L, Wang X, Dong H, Li L, Fu D, Li Y, Zi X, Liu HM, Zhang Y, Xu H, Jin CY. A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells. Sci Rep. 2017 Aug 29; 7(1):9873. PMID: 28852176.
      View in: PubMed
    5. Jandial DD, Krill LS, Chen L, Wu C, Ke Y, Xie J, Hoang BH, Zi X. Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin. Molecules. 2017 Mar 14; 22(3). PMID: 28335434.
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    6. Li LH, Tu QY, Deng XH, Xia J, Hou DR, Guo K, Zi X. Mutant presenilin2 promotes apoptosis through the p53/miR-34a axis in neuronal cells. Brain Res. 2017 05 01; 1662:57-64. PMID: 28189560.
      View in: PubMed
    7. Ma YC, Ke Y, Zi X, Zhao F, Yuan L, Zhu YL, Fan XX, Zhao NM, Li QY, Qin YH, Liu HM. Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species. Oncotarget. 2016 Dec 27; 7(52):86211-86224. PMID: 27863415.
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    8. Zhang S, Li T, Zhang Y, Xu H, Li Y, Zi X, Yu H, Li J, Jin CY, Liu HM. A new brominated chalcone derivative suppresses the growth of gastric cancer cells in vitro and in vivo involving ROS mediated up-regulation of DR5 and 4 expression and apoptosis. Toxicol Appl Pharmacol. 2016 10 15; 309:77-86. PMID: 27594528.
      View in: PubMed
    9. Chen L, Xia G, Qiu F, Wu C, Denmon AP, Zi X. Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2a and inhibits tumor growth. Sci Rep. 2016 09 01; 6:32582. PMID: 27581364.
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    10. Zi X, Lusch A, Blair CA, Okhunov Z, Yokoyama NN, Liu S, Baker M, Huynh V, Landman J. Effect of perineoplasm perinephric adipose tissues on migration of clear cell renal cell carcinoma cells: a potential role of WNT signaling. Oncotarget. 2016 Aug 16; 7(33):53277-53288. PMID: 27409168.
      View in: PubMed
    11. Chen LX, Xia GY, He H, Huang J, Qiu F, Zi X. New withanolides with TRAIL-sensitizing effect from Physalis pubescens L. RSC Adv. 2016; 6(58):52925-52936. PMID: 27822364.
      View in: PubMed
    12. Liu Z, Yokoyama NN, Blair CA, Li X, Avizonis D, Wu XR, Uchio E, Youssef R, McClelland M, Pollak M, Zi X. High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ~240-Fold Higher Drug Concentration in Urine than Serum. Mol Cancer Ther. 2016 Mar; 15(3):430-8. PMID: 26921394; PMCID: PMC4783238 [Available on 03/01/17].
    13. Li X, Yokoyama NN, Zhang S, Ding L, Liu HM, Lilly MB, Mercola D, Zi X. Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model. Oncotarget. 2015 Dec 08; 6(39):41809-24. PMID: 26497688; PMCID: PMC4747190.
    14. Hidas G, Lee HJ, Bahoric A, Kelly MS, Watts B, Liu Z, Saharti S, Lusch A, Alamsahebpour A, Kerbl D, Truong H, Zi X, Khoury AE. Aerosol transfer of bladder urothelial and smooth muscle cells onto demucosalized colonic segments for bladder augmentation: in vivo, long term, and functional pilot study. J Pediatr Urol. 2015 Oct; 11(5):260.e1-6. PMID: 26022502; PMCID: PMC4623943 [Available on 10/01/16].
    15. Ji T, Guo Y, Kim K, McQueen P, Ghaffar S, Christ A, Lin C, Eskander R, Zi X, Hoang BH. Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma. Mol Cancer. 2015 Apr 17; 14:86. PMID: 25890345; PMCID: PMC4411772.
    16. Yokoyama NN, Denmon A, Uchio EM, Jordan M, Mercola D, Zi X. When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow? Curr Pharmacol Rep. 2015 Dec 01; 1(6):420-433. PMID: 26756023.
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    17. Ma YC, Su N, Shi XJ, Zhao W, Ke Y, Zi X, Zhao NM, Qin YH, Zhao HW, Liu HM. Jaridonin-induced G2/M phase arrest in human esophageal cancer cells is caused by reactive oxygen species-dependent Cdc2-tyr15 phosphorylation via ATM-Chk1/2-Cdc25C pathway. Toxicol Appl Pharmacol. 2015 Jan 15; 282(2):227-36. PMID: 25450480; PMCID: PMC4721529.
    18. Lee C, Jia Z, Rahmatpanah F, Zhang Q, Zi X, McClelland M, Mercola D. Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-ß and IGF signaling. Biomed Res Int. 2014; 2014:502093. PMID: 25089270; PMCID: PMC4095744.
    19. Yokoyama NN, Shao S, Hoang BH, Mercola D, Zi X. Wnt signaling in castration-resistant prostate cancer: implications for therapy. Am J Clin Exp Urol. 2014 Apr 15; 2(1):27-44. PMID: 25143959; PMCID: PMC4219296.
    20. Li X, Xu X, Ji T, Liu Z, Gu M, Hoang BH, Zi X. Dietary feeding of Flavokawain A, a Kava chalcone, exhibits a satisfactory safety profile and its association with enhancement of phase II enzymes in mice. Toxicol Rep. 2014; 1:2-11. PMID: 25379458.
      View in: PubMed
    21. Jandial DD, Blair CA, Zhang S, Krill LS, Zhang YB, Zi X. Molecular targeted approaches to cancer therapy and prevention using chalcones. Curr Cancer Drug Targets. 2014; 14(2):181-200. PMID: 24467530; PMCID: PMC4107204.
    22. Zheng YC, Duan YC, Ma JL, Xu RM, Zi X, Lv WL, Wang MM, Ye XW, Zhu S, Mobley D, Zhu YY, Wang JW, Li JF, Wang ZR, Zhao W, Liu HM. Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration. J Med Chem. 2013 Nov 14; 56(21):8543-60. PMID: 24131029; PMCID: PMC3881423.
    23. Liu Z, Xu X, Li X, Liu S, Simoneau AR, He F, Wu XR, Zi X. Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model. Cancer Prev Res (Phila). 2013 Dec; 6(12):1365-75. PMID: 24121102; PMCID: PMC3873822.
    24. Ma YC, Ke Y, Zi X, Zhao W, Shi XJ, Liu HM. Jaridonin, a novel ent-kaurene diterpenoid from Isodon rubescens, inducing apoptosis via production of reactive oxygen species in esophageal cancer cells. Curr Cancer Drug Targets. 2013 Jul; 13(6):611-24. PMID: 23597192; PMCID: PMC3750090.
    25. Ji T, Lin C, Krill LS, Eskander R, Guo Y, Zi X, Hoang BH. Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis. Mol Cancer. 2013 Jun 10; 12:55. PMID: 23764122; PMCID: PMC3681603.
    26. Zi X, Zhang R. Anti-cancer molecular targets of natural products. Curr Cancer Drug Targets. 2013 Jun; 13(5):485. PMID: 23802843.
      View in: PubMed
    27. Tian X, Zhang S, Liu HM, Zhang YB, Blair CA, Mercola D, Sassone-Corsi P, Zi X. Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention. Curr Cancer Drug Targets. 2013 Jun; 13(5):558-79. PMID: 23713993; PMCID: PMC3703250.
    28. Lin CH, Guo Y, Ghaffar S, McQueen P, Pourmorady J, Christ A, Rooney K, Ji T, Eskander R, Zi X, Hoang BH. Dkk-3, a secreted wnt antagonist, suppresses tumorigenic potential and pulmonary metastasis in osteosarcoma. Sarcoma. 2013; 2013:147541. PMID: 23476112; PMCID: PMC3582188.
    29. Liu Z, Antalek M, Nguyen L, Li X, Tian X, Le A, Zi X. The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines. Nutr Cancer. 2013; 65 Suppl 1:68-77. PMID: 23682785; PMCID: PMC3671488.
    30. Wang Y, Zi X, Su J, Zhang HX, Zhang XR, Zhu HY, Li JX, Yin M, Yang F, Hu YP. Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells. Int J Nanomedicine. 2012; 7:2641-52. PMID: 22679374; PMCID: PMC3368515.
    31. Eskander RN, Randall LM, Sakai T, Guo Y, Hoang B, Zi X. Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line. J Obstet Gynaecol Res. 2012 Aug; 38(8):1086-94. PMID: 22540374; PMCID: PMC3405181.
    32. Dellinger TH, Planutis K, Jandial DD, Eskander RN, Martinez ME, Zi X, Monk BJ, Holcombe RF. Expression of the Wnt antagonist Dickkopf-3 is associated with prognostic clinicopathologic characteristics and impairs proliferation and invasion in endometrial cancer. Gynecol Oncol. 2012 Aug; 126(2):259-67. PMID: 22555103; PMCID: PMC3688285.
    33. Li X, Liu Z, Xu X, Blair CA, Sun Z, Xie J, Lilly MB, Zi X. Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice. PLoS One. 2012; 7(2):e31213. PMID: 22347450; PMCID: PMC3276576.
    34. Sakai T, Eskander RN, Guo Y, Kim KJ, Mefford J, Hopkins J, Bhatia NN, Zi X, Hoang BH. Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. J Orthop Res. 2012 Jul; 30(7):1045-50. PMID: 22213202; PMCID: PMC3685290.
    35. Blair CA, Zi X. Potential molecular targeting of splice variants for cancer treatment. Indian J Exp Biol. 2011 Nov; 49(11):836-9. PMID: 22126014; PMCID: PMC3253385.
    36. McQueen P, Ghaffar S, Guo Y, Rubin EM, Zi X, Hoang BH. The Wnt signaling pathway: implications for therapy in osteosarcoma. Expert Rev Anticancer Ther. 2011 Aug; 11(8):1223-32. PMID: 21916576.
      View in: PubMed
    37. Su J, You P, Zhao JP, Zhang SL, Song SH, Fu ZR, Ye LW, Zi X, Xie DF, Zhu MH, Hu YP. A potential role for the homeoprotein Hhex in hepatocellular carcinoma progression. Med Oncol. 2012 Jun; 29(2):1059-67. PMID: 21656028.
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    38. Liu Z, Li X, Simoneau AR, Jafari M, Zi X. Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Mol Carcinog. 2012 Mar; 51(3):257-67. PMID: 21520297; PMCID: PMC3144985.
    39. Tang Y, Parmakhtiar B, Simoneau AR, Xie J, Fruehauf J, Lilly M, Zi X. Lycopene enhances docetaxel's effect in castration-resistant prostate cancer associated with insulin-like growth factor I receptor levels. Neoplasia. 2011 Feb; 13(2):108-19. PMID: 21403837; PMCID: PMC3033590.
    40. Tang Y, Li X, Liu Z, Simoneau AR, Xie J, Zi X. Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth. Int J Cancer. 2010 Oct 15; 127(8):1758-68. PMID: 20112340; PMCID: PMC2888737.
    41. Yee DS, Tang Y, Li X, Liu Z, Guo Y, Ghaffar S, McQueen P, Atreya D, Xie J, Simoneau AR, Hoang BH, Zi X. The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Mol Cancer. 2010 Jun 23; 9:162. PMID: 20573255; PMCID: PMC2907330.
    42. Rubin EM, Guo Y, Tu K, Xie J, Zi X, Hoang BH. Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol Cancer Ther. 2010 Mar; 9(3):731-41. PMID: 20197388; PMCID: PMC2837364.
    43. Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Hoang BH, Zi X. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther. 2009 Feb; 8(2):458-68. PMID: 19174556; PMCID: PMC2768341.
    44. Tang Y, Simoneau AR, Xie J, Shahandeh B, Zi X. Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53. Cancer Prev Res (Phila). 2008 Nov; 1(6):439-51. PMID: 19138991; PMCID: PMC2830727.
    45. Guo Y, Rubin EM, Xie J, Zi X, Hoang BH. Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model. Clin Orthop Relat Res. 2008 Sep; 466(9):2039-45. PMID: 18566875; PMCID: PMC2493003.
    46. Guo Y, Xie J, Rubin E, Tang YX, Lin F, Zi X, Hoang BH. Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res. 2008 May 01; 68(9):3350-60. PMID: 18451162; PMCID: PMC2824245.
    47. Guo Y, Zi X, Koontz Z, Kim A, Xie J, Gorlick R, Holcombe RF, Hoang BH. Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. J Orthop Res. 2007 Jul; 25(7):964-71. PMID: 17318900.
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    48. Zhang RX, Tang BS, Zi X, Xia K, Pan Q, Zhang FF, Li SJ, Zhao GH, Guo K. [Study on aggregate formation mechanism of HSPB8 gene mutation resulting in CMT2L]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Dec; 23(6):601-4. PMID: 17160934.
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    49. Zi X, Guo Y, Simoneau AR, Hope C, Xie J, Holcombe RF, Hoang BH. Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res. 2005 Nov 01; 65(21):9762-70. PMID: 16266997.
      View in: PubMed
    50. Fan XJ, Guo K, Xiao B, Zi X, Song Z. [Effects of sodium aescinate on bcl-2 and caspase-3 expression and apoptosis after focal cerebral ischemia reperfusion injury in rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Jun; 30(3):261-5, 275. PMID: 16045009.
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    51. Zi X, Simoneau AR. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res. 2005 Apr 15; 65(8):3479-86. PMID: 15833884.
      View in: PubMed
    52. Shibuya TY, Kim S, Nguyen K, Do J, McLaren CE, Li KT, Chen WP, Parikh P, Wadhwa A, Zi X, Chen VY, Wong HS, Armstrong WB, Yoo GH. Bioactive suture: a novel immunotherapy for head and neck cancer. Clin Cancer Res. 2004 Oct 15; 10(20):7088-99. PMID: 15501989.
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    53. Lu Y, Zi X, Pollak M. Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells. Int J Cancer. 2004 Jan 20; 108(3):334-41. PMID: 14648698.
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    54. Lu Y, Zi X, Zhao Y, Pollak M. Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells. Biochem Biophys Res Commun. 2004 Jan 16; 313(3):709-15. PMID: 14697248.
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