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Flodman, Pamela L

Title(s)Adjunct Professor, Pediatrics
Phone(714) 456-5789; (949) 824-9786
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Qian E, Thong MK, Flodman P, Gargus J. A comparative study of patients' perceptions of genetic and genomic medicine services in California and Malaysia. J Community Genet. 2019 Jul; 10(3):351-361. PMID: 30506521.
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    2. Smith M, Flodman PL. Expanded Insights Into Mechanisms of Gene Expression and Disease Related Disruptions. Front Mol Biosci. 2018; 5:101. PMID: 30542652.
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    3. Saba LM, Flink SC, Vanderlinden LA, Israel Y, Tampier L, Colombo G, Kiianmaa K, Bell RL, Printz MP, Flodman P, Koob G, Richardson HN, Lombardo J, Hoffman PL, Tabakoff B. The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption. FEBS J. 2015 Sep; 282(18):3556-78. PMID: 26183165.
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    4. Vanderlinden LA, Saba LM, Printz MP, Flodman P, Koob G, Richardson HN, Hoffman PL, Tabakoff B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcohol Clin Exp Res. 2014 Jul; 38(7):2148-57. PMID: 24961585; PMCID: PMC4142977.
    5. Greenwood J, Flodman P, Osann K, Boyadjiev SA, Kimonis V. Familial incidence and associated symptoms in a population of individuals with nonsyndromic craniosynostosis. Genet Med. 2014 Apr; 16(4):302-10. PMID: 24071792.
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    6. Gold JA, Ruth C, Osann K, Flodman P, McManus B, Lee HS, Donkervoort S, Khare M, Roof E, Dykens E, Miller JL, Driscoll DJ, Butler MG, Heinemann J, Cassidy S, Kimonis VE. Frequency of Prader-Willi syndrome in births conceived via assisted reproductive technology. Genet Med. 2014 Feb; 16(2):164-9. PMID: 23928912.
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    7. Devers PL, Cronister A, Ormond KE, Facio F, Brasington CK, Flodman P. Noninvasive prenatal testing/noninvasive prenatal diagnosis: the position of the National Society of Genetic Counselors. J Genet Couns. 2013 Jun; 22(3):291-5. PMID: 23334531.
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    8. Smith M, Flodman PL, Gargus JJ, Simon MT, Verrell K, Haas R, Reiner GE, Naviaux R, Osann K, Spence MA, Wallace DC. Mitochondrial and ion channel gene alterations in autism. Biochim Biophys Acta. 2012 Oct; 1817(10):1796-802. PMID: 22538295; PMCID: PMC3423964.
    9. Newman ZL, Printz MP, Liu S, Crown D, Breen L, Miller-Randolph S, Flodman P, Leppla SH, Moayeri M. Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1. PLoS Pathog. 2010 May 20; 6(5):e1000906. PMID: 20502689; PMCID: PMC2873920.
    10. Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL. Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol. 2009 Oct 27; 7:70. PMID: 19874574.
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    11. Gage NM, Juranek J, Filipek PA, Osann K, Flodman P, Isenberg AL, Spence MA. Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation. J Neurodev Disord. 2009 Sep; 1(3):205-14. PMID: 19816533.
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    12. Smith M, Spence MA, Flodman P. Nuclear and mitochondrial genome defects in autisms. Ann N Y Acad Sci. 2009 Jan; 1151:102-32. PMID: 19154520.
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    13. Neuhausen SL, Steele L, Ryan S, Mousavi M, Pinto M, Osann KE, Flodman P, Zone JJ. Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives. J Autoimmun. 2008 Sep; 31(2):160-5. PMID: 18692362.
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    14. Gotham K, Risi S, Dawson G, Tager-Flusberg H, Joseph R, Carter A, Hepburn S, McMahon W, Rodier P, Hyman SL, Sigman M, Rogers S, Landa R, Spence MA, Osann K, Flodman P, Volkmar F, Hollander E, Buxbaum J, Pickles A, Lord C. A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms. J Am Acad Child Adolesc Psychiatry. 2008 Jun; 47(6):642-51. PMID: 18434924.
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    15. Richter L, Flodman P, Barria von-Bischhoffshausen F, Burch D, Brown S, Nguyen L, Turner J, Spence MA, Bateman JB. Clinical variability of autosomal dominant cataract, microcornea and corneal opacity and novel mutation in the alpha A crystallin gene (CRYAA). Am J Med Genet A. 2008 Apr 01; 146A(7):833-42. PMID: 18302245.
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    16. Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu XQ, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, Marshall CR, Scherer SW, Vieland VJ, Bartlett C, Mangin LV, Goedken R, Segre A, Pericak-Vance MA, Cuccaro ML, Gilbert JR, Wright HH, Abramson RK, Betancur C, Bourgeron T, Gillberg C, Leboyer M, Buxbaum JD, Davis KL, Hollander E, Silverman JM, Hallmayer J, Lotspeich L, Sutcliffe JS, Haines JL, Folstein SE, Piven J, Wassink TH, Sheffield V, Geschwind DH, Bucan M, Brown WT, Cantor RM, Constantino JN, Gilliam TC, Herbert M, Lajonchere C, Ledbetter DH, Lese-Martin C, Miller J, Nelson S, Samango-Sprouse CA, Spence S, State M, Tanzi RE, Coon H, Dawson G, Devlin B, Estes A, Flodman P, Klei L, McMahon WM, Minshew N, Munson J, Korvatska E, Rodier PM, Schellenberg GD, Smith M, Spence MA, Stodgell C, Tepper PG, Wijsman EM, Yu CE, Rogé B, Mantoulan C, Wittemeyer K, Poustka A, Felder B, Klauck SM, Schuster C, Poustka F, Bölte S, Feineis-Matthews S, Herbrecht E, Schmötzer G, Tsiantis J, Papanikolaou K, Maestrini E, Bacchelli E, Blasi F, Carone S, Toma C, Van Engeland H, de Jonge M, Kemner C, Koop F, Koop F, Langemeijer M, Langemeijer M, Hijmans C, Hijimans C, Staal WG, Baird G, Bolton PF, Rutter ML, Weisblatt E, Green J, Aldred C, Wilkinson JA, Pickles A, Le Couteur A, Berney T, McConachie H, Bailey AJ, Francis K, Honeyman G, Hutchinson A, Parr JR, Wallace S, Monaco AP, Barnby G, Kobayashi K, Lamb JA, Sousa I, Sykes N, Cook EH, Guter SJ, Leventhal BL, Salt J, Lord C, Corsello C, Hus V, Weeks DE, Volkmar F, Tauber M, Fombonne E, Shih A, Meyer KJ. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet. 2007 Mar; 39(3):319-28. PMID: 17322880.
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    17. Ogino S, Wilson RB, Gold B, Flodman P. Bayesian risk assessment in genetic testing for autosomal dominant disorders with age-dependent penetrance. J Genet Couns. 2007 Feb; 16(1):29-39. PMID: 17295057.
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    18. Bateman JB, von-Bischhoffshaunsen FR, Richter L, Flodman P, Burch D, Spence MA. Gene conversion mutation in crystallin, beta-B2 (CRYBB2) in a Chilean family with autosomal dominant cataract. Ophthalmology. 2007 Mar; 114(3):425-32. PMID: 17234267.
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    19. Bateman JB, Richter L, Flodman P, Burch D, Brown S, Penrose P, Paul O, Geyer DD, Brooks DG, Spence MA. A new locus for autosomal dominant cataract on chromosome 19: linkage analyses and screening of candidate genes. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3441-9. PMID: 16877414.
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    20. Schellenberg GD, Dawson G, Sung YJ, Estes A, Munson J, Rosenthal E, Rothstein J, Flodman P, Smith M, Coon H, Leong L, Yu CE, Stodgell C, Rodier PM, Spence MA, Minshew N, McMahon WM, Wijsman EM. Evidence for multiple loci from a genome scan of autism kindreds. Mol Psychiatry. 2006 Nov; 11(11):1049-60, 979. PMID: 16880825.
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    21. Geyer DD, Spence MA, Johannes M, Flodman P, Clancy KP, Berry R, Sparkes RS, Jonsen MD, Isenberg SJ, Bateman JB. Novel single-base deletional mutation in major intrinsic protein (MIP) in autosomal dominant cataract. Am J Ophthalmol. 2006 Apr; 141(4):761-3. PMID: 16564824; PMCID: PMC1463993.
    22. Grady DL, Harxhi A, Smith M, Flodman P, Spence MA, Swanson JM, Moyzis RK. Sequence variants of the DRD4 gene in autism: further evidence that rare DRD4 7R haplotypes are ADHD specific. Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 05; 136B(1):33-5. PMID: 15892149.
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    23. Ogino S, Flodman P, Wilson RB, Gold B, Grody WW. Risk calculations for cystic fibrosis in neonatal screening by immunoreactive trypsinogen and CFTR mutation tests. Genet Med. 2005 May-Jun; 7(5):317-27. PMID: 15915083.
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    24. Leung PW, Lee CC, Hung SF, Ho TP, Tang CP, Kwong SL, Leung SY, Yuen ST, Lieh-Mak F, Oosterlaan J, Grady D, Harxhi A, Ding YC, Chi HC, Flodman P, Schuck S, Spence MA, Moyzis R, Swanson J. Dopamine receptor D4 (DRD4) gene in Han Chinese children with attention-deficit/hyperactivity disorder (ADHD): increased prevalence of the 2-repeat allele. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 05; 133B(1):54-6. PMID: 15578612.
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    25. Hodge SE, Flodman PL. Risk calculations: still essential in the molecular age. Am J Med Genet A. 2004 Sep 01; 129A(3):215-7. PMID: 15326619.
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    26. Ramanathan S, Woodroffe A, Flodman PL, Mays LZ, Hanouni M, Modahl CB, Steinberg-Epstein R, Bocian ME, Spence MA, Smith M. A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R. BMC Med Genet. 2004 Apr 16; 5:10. PMID: 15090072; PMCID: PMC411038.
    27. Wang E, Ding YC, Flodman P, Kidd JR, Kidd KK, Grady DL, Ryder OA, Spence MA, Swanson JM, Moyzis RK. The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet. 2004 May; 74(5):931-44. PMID: 15077199; PMCID: PMC1181986.
    28. Goldberg WA, Osann K, Filipek PA, Laulhere T, Jarvis K, Modahl C, Flodman P, Spence MA. Language and other regression: assessment and timing. J Autism Dev Disord. 2003 Dec; 33(6):607-16. PMID: 14714930.
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    29. Grady DL, Chi HC, Ding YC, Smith M, Wang E, Schuck S, Flodman P, Spence MA, Swanson JM, Moyzis RK. High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder. Mol Psychiatry. 2003 May; 8(5):536-45. PMID: 12808433.
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    30. Flodman P, Hodge SE. Sex-specific mutation rates for x-linked disorders: estimation and application. Hum Hered. 2003; 55(1):51-5. PMID: 12890926.
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    31. Palmer AA, Breen LL, Flodman P, Conti LH, Spence MA, Printz MP. Identification of quantitative trait loci for prepulse inhibition in rats. Psychopharmacology (Berl). 2003 Jan; 165(3):270-9. PMID: 12426667.
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    32. Neiswanger K, Cooper ME, Weinberg SM, Flodman P, Keglovits AB, Liu Y, Hu DN, Melnick M, Spence MA, Marazita ML. Cleft lip with or without cleft palate and dermatoglyphic asymmetry: evaluation of a Chinese population. Orthod Craniofac Res. 2002 Aug; 5(3):140-6. PMID: 12194662.
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    33. Yu CE, Dawson G, Munson J, D'Souza I, Osterling J, Estes A, Leutenegger AL, Flodman P, Smith M, Raskind WH, Spence MA, McMahon W, Wijsman EM, Schellenberg GD. Presence of large deletions in kindreds with autism. Am J Hum Genet. 2002 Jul; 71(1):100-15. PMID: 12058345; PMCID: PMC384967.
    34. Flodman P, Hodge SE. Determining Complex Genetic Risks by Computer. J Genet Couns. 2002 Jun; 11(3):213-30. PMID: 26141858.
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    35. Jaworski RL, Jirout M, Closson S, Breen L, Flodman PL, Spence MA, Kren V, Krenova D, Pravenec M, Printz MP. Heart rate and blood pressure quantitative trait loci for the airpuff startle reaction. Hypertension. 2002 Feb; 39(2 Pt 2):348-52. PMID: 11882571.
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    36. Smith M, Woodroffe A, Smith R, Holguin S, Martinez J, Filipek PA, Modahl C, Moore B, Bocian ME, Mays L, Laulhere T, Flodman P, Spence MA. Molecular genetic delineation of a deletion of chromosome 13q12-->q13 in a patient with autism and auditory processing deficits. Cytogenet Genome Res. 2002; 98(4):233-9. PMID: 12826745.
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    37. Ding YC, Chi HC, Grady DL, Morishima A, Kidd JR, Kidd KK, Flodman P, Spence MA, Schuck S, Swanson JM, Zhang YP, Moyzis RK. Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):309-14. PMID: 11756666; PMCID: PMC117557.
    38. Flodman P, Hodge SE. A genetic risk calculation surprise. Am J Med Genet. 2001 Apr 22; 100(2):169-71. PMID: 11298381.
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    39. Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL, Masser D, Ungerleider S, Rapaport MH, Wishart WL, Luebbert H. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci U S A. 2001 Jan 16; 98(2):585-90. PMID: 11149935.
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    40. Smith M, Escamilla JR, Filipek P, Bocian ME, Modahl C, Flodman P, Spence MA. Molecular genetic delineation of 2q37.3 deletion in autism and osteodystrophy: report of a case and of new markers for deletion screening by PCR. Cytogenet Cell Genet. 2001; 94(1-2):15-22. PMID: 11701947.
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    41. Flodman P, Macula AJ, Spence MA, Torney DC. Preliminary implementation of new data mining techniques for the analysis of simulation data from Genetic Analysis Workshop 12: problem 2. Genet Epidemiol. 2001; 21 Suppl 1:S390-5. PMID: 11793705.
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    42. Bateman JB, Geyer DD, Flodman P, Johannes M, Sikela J, Walter N, Moreira AT, Clancy K, Spence MA. A new betaA1-crystallin splice junction mutation in autosomal dominant cataract. Invest Ophthalmol Vis Sci. 2000 Oct; 41(11):3278-85. PMID: 11006214.
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    43. Bateman JB, Johannes M, Flodman P, Geyer DD, Clancy KP, Heinzmann C, Kojis T, Berry R, Sparkes RS, Spence MA. A new locus for autosomal dominant cataract on chromosome 12q13. Invest Ophthalmol Vis Sci. 2000 Aug; 41(9):2665-70. PMID: 10937580.
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    44. Swanson J, Oosterlaan J, Murias M, Schuck S, Flodman P, Spence MA, Wasdell M, Ding Y, Chi HC, Smith M, Mann M, Carlson C, Kennedy JL, Sergeant JA, Leung P, Zhang YP, Sadeh A, Chen C, Whalen CK, Babb KA, Moyzis R, Posner MI. Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4754-9. PMID: 10781080.
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    45. Martin RA, Hunter V, Neufeld-Kaiser W, Flodman P, Spence MA, Furnas D, Martin KA. Ultrasonographic detection of orbicularis oris defects in first degree relatives of isolated cleft lip patients. Am J Med Genet. 2000 Jan 17; 90(2):155-61. PMID: 10607956.
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    46. Swanson JM, Flodman P, Kennedy J, Spence MA, Moyzis R, Schuck S, Murias M, Moriarity J, Barr C, Smith M, Posner M. Dopamine genes and ADHD. Neurosci Biobehav Rev. 2000 Jan; 24(1):21-5. PMID: 10654656.
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    47. Hodge SE, Flodman PL, Duryea MF, Spence MA. Estimating recombination fraction separately for males and females: a counterintuitive result. Hum Hered. 1998 Jan-Feb; 48(1):42-8. PMID: 9463801.
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    48. Hayduk R, Flodman P, Spence MA, Erman MK, Mitler MM. HLA haplotypes, polysomnography, and pedigrees in a case series of patients with narcolepsy. Sleep. 1997 Oct; 20(10):850-7. PMID: 9415944.
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    49. Homer JP, Flodman PL, Spence MA. Bipolar disorder: dominant or recessive on chromosome 5? Genet Epidemiol. 1997; 14(6):647-51. PMID: 9433557.
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    50. Kelsoe JR, Sadovnick AD, Kristbjarnarson H, Bergesch P, Mroczkowski-Parker Z, Drennan M, Rapaport MH, Flodman P, Spence MA, Remick RA. Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. Am J Med Genet. 1996 Nov 22; 67(6):533-40. PMID: 8950410.
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    51. Kelsoe JR, Remick RA, Sadovnick AD, Kristbjarnarson H, Flodman P, Spence MA, Morison M, Mroczkowski-Parker Z, Bergesch P, Rapaport MH, Mirow AL, Blakely RD, Helgason T, Egeland JA. Genetic linkage study of bipolar disorder and the serotonin transporter. Am J Med Genet. 1996 Apr 09; 67(2):215-7. PMID: 8723051.
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    52. Kojis TL, Heinzmann C, Flodman P, Ngo JT, Sparkes RS, Spence MA, Bateman JB, Heckenlively JR. Map refinement of locus RP13 to human chromosome 17p13.3 in a second family with autosomal dominant retinitis pigmentosa. Am J Hum Genet. 1996 Feb; 58(2):347-55. PMID: 8571961.
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    53. Pravenec M, Gauguier D, Schott JJ, Buard J, Kren V, Bílá V, Szpirer C, Szpirer J, Wang JM, Huang H, St Lezin E, Spence MA, Flodman P, Printz M, Lathrop GM, Vergnaud G, Kurtz TW. A genetic linkage map of the rat derived from recombinant inbred strains. Mamm Genome. 1996 Feb; 7(2):117-27. PMID: 8835528.
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    54. Spence MA, Flodman PL, Sadovnick AD, Bailey-Wilson JE, Ameli H, Remick RA. Bipolar disorder: evidence for a major locus. Am J Med Genet. 1995 Oct 09; 60(5):370-6. PMID: 8546148.
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    55. Mogil JS, Flodman P, Spence MA, Sternberg WF, Kest B, Sadowski B, Liebeskind JC, Belknap JK. Oligogenic determination of morphine analgesic magnitude: a genetic analysis of selectively bred mouse lines. Behav Genet. 1995 Jul; 25(4):397-406. PMID: 7575370.
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    56. Mogil JS, Marek P, Flodman P, Spence MA, Sternberg WF, Kest B, Sadowski B, Liebeskind JC. One or two genetic loci mediate high opiate analgesia in selectively bred mice. Pain. 1995 Feb; 60(2):125-35. PMID: 7784097.
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    57. Munier FL, Arabien L, Flodman P, Spence MA, Pescia G, Rutz HP, Murphree AL. Putative non-Mendelian transmission of retinoblastoma in males: a phenotypic segregation analysis of 150 pedigrees. Hum Genet. 1994 Nov; 94(5):484-90. PMID: 7959681.
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    58. Janssen LA, Povey S, Attwood J, Sandkuyl LA, Lindhout D, Flodman P, Smith M, Sampson JR, Haines JL, Merkens EC. A comparative study on genetic heterogeneity in tuberous sclerosis: evidence for one gene on 9q34 and a second gene on 11q22-23. Ann N Y Acad Sci. 1991; 615:306-15. PMID: 2039153.
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    59. Smith M, Yoshiyama K, Wagner C, Flodman P, Smith B. Genetic heterogeneity in tuberous sclerosis. Map position of the TSC2 locus on chromosome 11q and future prospects. Ann N Y Acad Sci. 1991; 615:274-83. PMID: 1674845.
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    60. Haines JL, Amos J, Attwood J, Bech-Hansen NT, Burley M, Conneally PM, Connor JM, Fahsold R, Flodman P, Fryer A. Genetic heterogeneity in tuberous sclerosis. Study of a large collaborative dataset. Ann N Y Acad Sci. 1991; 615:256-64. PMID: 1674844.
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    61. Povey S, Attwood J, Janssen LA, Burley M, Smith M, Flodman P, Morton NE, Edwards JH, Sampson JR, Yates JR. An attempt to map two genes for tuberous sclerosis using novel two-point methods. Ann N Y Acad Sci. 1991; 615:298-305. PMID: 1674846.
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    62. Smith M, Smalley S, Cantor R, Pandolfo M, Gomez MI, Baumann R, Flodman P, Yoshiyama K, Nakamura Y, Julier C. Mapping of a gene determining tuberous sclerosis to human chromosome 11q14-11q23. Genomics. 1990 Jan; 6(1):105-14. PMID: 2303253.
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