Eva Y Lee

Title(s)Professor Emeritus, Biological Chemistry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-9766
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    1. Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer. Sci Transl Med. 2021 03 03; 13(583). Wu HH, Tsai LH, Huang CK, Hsu PH, Chen MY, Chen YI, Hu CM, Shen CN, Lee CC, Chang MC, Chang YT, Tien YW, Jeng YM, Lee EYP, Lee WH. PMID: 33658352.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    2. Redox sensor NPGPx restrains ZAP70 activity and modulates T cell homeostasis. Free Radic Biol Med. 2021 03; 165:368-384. Su FY, Huang SC, Wei PC, Hsu PH, Li JP, Su LW, Hsieh YL, Hu CM, Hsu JL, Yang CY, Chung CY, Shew JY, Lan JL, Sytwu HK, Lee EY, Lee WH. PMID: 33460768.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells. Cell Metab. 2019 06 04; 29(6):1334-1349.e10. Hu CM, Tien SC, Hsieh PK, Jeng YM, Chang MC, Chang YT, Chen YJ, Chen YJ, Lee EYP, Lee WH. PMID: 30853214.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    4. TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB. EMBO Mol Med. 2017 12; 9(12):1660-1680. Huang SC, Wei PC, Hwang-Verslues WW, Kuo WH, Jeng YM, Hu CM, Shew JY, Huang CS, Chang KJ, Lee EY, Lee WH. PMID: 28993429; PMCID: PMC5709760.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    5. Clinical Significance of Circulating Tumor Microemboli as a Prognostic Marker in Patients with Pancreatic Ductal Adenocarcinoma. Clin Chem. 2016 Mar; 62(3):505-13. Chang MC, Chang YT, Chen JY, Jeng YM, Yang CY, Tien YW, Yang SH, Chen HL, Liang TY, Wang CF, Lee EY, Chang YC, Lee WH. PMID: 26861552.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    6. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. J Exp Med. 2015 Mar 09; 212(3):333-49. Wu HH, Hwang-Verslues WW, Lee WH, Huang CK, Wei PC, Chen CL, Shew JY, Lee EY, Jeng YM, Tien YW, Ma C, Lee WH. PMID: 25732306; PMCID: PMC4354366.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    7. Tissue-specific tumor suppression by BRCA1. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4353-4. Lee EY, Abbondante S. PMID: 24639516; PMCID: PMC3970521.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    8. Progesterone receptor A stability is mediated by glycogen synthase kinase-3β in the Brca1-deficient mammary gland. J Biol Chem. 2013 Sep 06; 288(36):26265-26274. Wang S, Li Y, Hsu PH, Lee SY, Kim Y, Lee EYP. PMID: 23880761; PMCID: PMC3764830.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    9. Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12331-6. Hwang-Verslues WW, Chang PH, Jeng YM, Kuo WH, Chiang PH, Chang YC, Hsieh TH, Su FY, Lin LC, Abbondante S, Yang CY, Hsu HM, Yu JC, Chang KJ, Shew JY, Lee EY, Lee WH. PMID: 23836662; PMCID: PMC3725072.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    10. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell. 2012 Aug 03; 150(3):533-48. Chaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, Wang H, Hurd TW, Zhou W, Cluckey A, Gee HY, Ramaswami G, Hong CJ, Hamilton BA, Cervenka I, Ganji RS, Bryja V, Arts HH, van Reeuwijk J, Oud MM, Letteboer SJ, Roepman R, Husson H, Ibraghimov-Beskrovnaya O, Yasunaga T, Walz G, Eley L, Sayer JA, Schermer B, Liebau MC, Benzing T, Le Corre S, Drummond I, Janssen S, Allen SJ, Natarajan S, O'Toole JF, Attanasio M, Saunier S, Antignac C, Koenekoop RK, Ren H, Lopez I, Nayir A, Stoetzel C, Dollfus H, Massoudi R, Gleeson JG, Andreoli SP, Doherty DG, Lindstrad A, Golzio C, Katsanis N, Pape L, Abboud EB, Al-Rajhi AA, Lewis RA, Omran H, Lee EY, Wang S, Sekiguchi JM, Saunders R, Johnson CA, Garner E, Vanselow K, Andersen JS, Shlomai J, Nurnberg G, Nurnberg P, Levy S, Smogorzewska A, Otto EA, Hildebrandt F. PMID: 22863007; PMCID: PMC3433835.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCells
    11. Activation of Robo1 signaling of breast cancer cells by Slit2 from stromal fibroblast restrains tumorigenesis via blocking PI3K/Akt/β-catenin pathway. Cancer Res. 2012 Sep 15; 72(18):4652-61. Chang PH, Hwang-Verslues WW, Chang YC, Chen CC, Hsiao M, Jeng YM, Chang KJ, Lee EY, Shew JY, Lee WH. PMID: 22826604; PMCID: PMC3445732.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    12. Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility. J Nat Prod. 2012 Mar 23; 75(3):370-7. Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Kim Y, Lee EY, Lee KH. PMID: 22304236; PMCID: PMC3311758.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis. PLoS One. 2011 Jan 13; 6(1):e15313. Tyan SW, Kuo WH, Huang CK, Pan CC, Shew JY, Chang KJ, Lee EY, Lee WH. PMID: 21249190; PMCID: PMC3020942.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    14. Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents. Bioorg Med Chem Lett. 2011 Jan 01; 21(1):52-7. Dong Y, Nakagawa-Goto K, Lai CY, Kim Y, Morris-Natschke SL, Lee EY, Bastow KF, Lee KH. PMID: 21147529; PMCID: PMC3011818.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent. J Nat Prod. 2010 Sep 24; 73(9):1553-8. Usami Y, Nakagawa-Goto K, Lang JY, Kim Y, Lai CY, Goto M, Sakurai N, Taniguchi M, Akiyama T, Morris-Natschke SL, Bastow KF, Cragg G, Newman DJ, Fujitake M, Takeya K, Hung MC, Lee EY, Lee KH. PMID: 20738103; PMCID: PMC2954497.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    16. Oncogenes and tumor suppressor genes. Cold Spring Harb Perspect Biol. 2010 Oct; 2(10):a003236. Lee EY, Muller WJ. PMID: 20719876; PMCID: PMC2944361.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansAnimals
    17. Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues. J Med Chem. 2010 Mar 11; 53(5):2299-308. Dong Y, Shi Q, Pai HC, Peng CY, Pan SL, Teng CM, Nakagawa-Goto K, Yu D, Liu YN, Wu PC, Bastow KF, Morris-Natschke SL, Brossi A, Lang JY, Hsu JL, Hung MC, Lee EY, Lee KH. PMID: 20148565; PMCID: PMC2849726.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    18. Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers. PLoS One. 2009 Dec 21; 4(12):e8377. Hwang-Verslues WW, Kuo WH, Chang PH, Pan CC, Wang HH, Tsai ST, Jeng YM, Shew JY, Kung JT, Chen CH, Lee EY, Chang KJ, Lee WH. PMID: 20027313; PMCID: PMC2793431.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    19. Deficiency of pRb family proteins and p53 in invasive urothelial tumorigenesis. Cancer Res. 2009 Dec 15; 69(24):9413-21. He F, Mo L, Zheng XY, Hu C, Lepor H, Lee EY, Sun TT, Wu XR. PMID: 19951992; PMCID: PMC2794922.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    20. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell. 2009 Jun 02; 15(6):514-26. Wang Y, Yang J, Zheng H, Tomasek GJ, Zhang P, McKeever PE, Lee EY, Zhu Y. PMID: 19477430; PMCID: PMC2721466.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    21. Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol. 2009 Jun 01; 185(5):811-26. Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, Li B, Dai X. PMID: 19487454; PMCID: PMC2711593.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    22. UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity. Cell Cycle. 2009 Feb 15; 8(4):655-64. Pan YR, Lee EY. PMID: 19197159.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    23. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol Cell Biol. 2009 Mar; 29(6):1411-20. Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA. PMID: 19114562; PMCID: PMC2648237.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansCells
    24. Breast cancer stem cells and tumor suppressor genes. J Formos Med Assoc. 2008 Oct; 107(10):751-66. Hwang-Verslues WW, Chang KJ, Lee EY, Lee WH. PMID: 18926942.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 2008 May 01; 68(9):3286-94. Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, Mason RP, Lee EY, Wu H, Parada LF. PMID: 18451155; PMCID: PMC2760841.
      View in: PubMed   Mentions: 143     Fields:    Translation:AnimalsCells
    26. Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. Cancer Res. 2008 May 01; 68(9):3243-50. Shafee N, Smith CR, Wei S, Kim Y, Mills GB, Hortobagyi GN, Stanbridge EJ, Lee EY. PMID: 18451150; PMCID: PMC2929908.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    27. Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes Dev. 2008 Mar 01; 22(5):587-600. Sivasubramaniam S, Sun X, Pan YR, Wang S, Lee EY. PMID: 18283122; PMCID: PMC2259029.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    28. Promotion of BRCA1-associated triple-negative breast cancer by ovarian hormones. Curr Opin Obstet Gynecol. 2008 Feb; 20(1):68-73. Lee EY. PMID: 18197009.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    29. Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis. Cancer Res. 2007 Sep 01; 67(17):8065-80. Deeb KK, Michalowska AM, Yoon CY, Krummey SM, Hoenerhoff MJ, Kavanaugh C, Li MC, Demayo FJ, Linnoila I, Deng CX, Lee EY, Medina D, Shih JH, Green JE. PMID: 17804718.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    30. Suppression of TGF-beta signaling by phospholipase D. Cell Cycle. 2007 Nov 15; 6(22):2840-5. Gadir N, Lee E, Garcia A, Toschi A, Foster DA. PMID: 18032924.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    31. Induction of glutathione transferase in insulin-like growth factor type I receptor-overexpressed hepatoma cells. Mol Pharmacol. 2007 Oct; 72(4):1082-93. Lee JY, Han CY, Yang JW, Smith C, Kim SK, Lee EY, Kim SG, Kang KW. PMID: 17615245.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    32. Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science. 2006 Dec 01; 314(5804):1467-70. Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY. PMID: 17138902.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    33. ErbB2 overexpression in p53-inactivated mammary epithelial cells. FEBS Lett. 2006 Nov 27; 580(27):6501-8. Yang JW, Lee EY, Kang KW. PMID: 17101136.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    34. Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell. 2006 Jul; 10(1):13-24. Furuta S, Wang JM, Wei S, Jeng YM, Jiang X, Gu B, Chen PL, Lee EY, Lee WH. PMID: 16843262.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    35. Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol Cell Biol. 2005 May; 25(9):3535-42. Chen PL, Liu F, Cai S, Lin X, Li A, Chen Y, Gu B, Lee EY, Lee WH. PMID: 15831459; PMCID: PMC1084307.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    36. Gene deletion in urothelium by specific expression of Cre recombinase. Am J Physiol Renal Physiol. 2005 Sep; 289(3):F562-8. Mo L, Cheng J, Lee EY, Sun TT, Wu XR. PMID: 15840768.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    37. Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res. 2004 May 15; 64(10):3525-32. Lin SC, Lee KF, Nikitin AY, Hilsenbeck SG, Cardiff RD, Li A, Kang KW, Frank SA, Lee WH, Lee EY. PMID: 15150107.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    38. The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell. 2004 Apr 16; 117(2):157-69. Sabatier C, Plump AS, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M. PMID: 15084255.
      View in: PubMed   Mentions: 173     Fields:    Translation:AnimalsCells
    39. Detection of kinase and phosphatase activities. Methods Mol Biol. 2004; 241:285-97. Post SM, Lee EY. PMID: 14970662.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    40. The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. Nucleic Acids Res. 2003 Oct 01; 31(19):5568-75. Post SM, Tomkinson AE, Lee EY. PMID: 14500819; PMCID: PMC206465.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    41. Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells. Mutat Res. 2003 Apr 09; 525(1-2):85-92. Yuan SS, Chang HL, Lee EY. PMID: 12650908.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    42. Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses. Nucleic Acids Res. 2002 Nov 15; 30(22):4815-22. Zhao S, Renthal W, Lee EY. PMID: 12433983; PMCID: PMC137160.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    43. Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member. Biochem Biophys Res Commun. 2002 Aug 30; 296(4):1019-25. Yuan SS, Yeh YT, Lee EY. PMID: 12200151.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    44. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 2002 Mar 01; 16(5):571-82. Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J. PMID: 11877377; PMCID: PMC155356.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansCells
    45. Arsenic-induced Mre11 phosphorylation is cell cycle-dependent and defective in NBS cells. DNA Repair (Amst). 2002 Feb 28; 1(2):137-42. Yuan SS, Su JH, Hou MF, Yang FW, Zhao S, Lee EY. PMID: 12509260.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
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