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Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma. N Engl J Med. 2023 Mar 02; 388(9):813-823.
Patel SP, Othus M, Chen Y, Wright GP, Yost KJ, Hyngstrom JR, Hu-Lieskovan S, Lao CD, Fecher LA, Truong TG, Eisenstein JL, Chandra S, Sosman JA, Kendra KL, Wu RC, Devoe CE, Deutsch GB, Hegde A, Khalil M, Mangla A, Reese AM, Ross MI, Poklepovic AS, Phan GQ, Onitilo AA, Yasar DG, Powers BC, Doolittle GC, In GK, Kokot N, Gibney GT, Atkins MB, Shaheen M, Warneke JA, Ikeguchi A, Najera JE, Chmielowski B, Crompton JG, Floyd JD, Hsueh E, Margolin KA, Chow WA, Grossmann KF, Dietrich E, Prieto VG, Lowe MC, Buchbinder EI, Kirkwood JM, Korde L, Moon J, Sharon E, Sondak VK, Ribas A. PMID: 36856617; PMCID: PMC10410527.
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PubMed Mentions:
116 Fields:
Translation:
HumansCTClinical Trials
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Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma. Nat Commun. 2022 09 08; 13(1):5296.
Gyurdieva A, Zajic S, Chang YF, Houseman EA, Zhong S, Kim J, Nathenson M, Faitg T, Woessner M, Turner DC, Hasan AN, Glod J, Kaplan RN, D'Angelo SP, Araujo DM, Chow WA, Druta M, Demetri GD, Van Tine BA, Grupp SA, Fine GD, Eleftheriadou I. PMID: 36075914; PMCID: PMC9458750.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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The cure from within? a review of the microbiome and diet in melanoma. Cancer Metastasis Rev. 2022 06; 41(2):261-280.
Kumar P, Brazel D, DeRogatis J, Valerin JBG, Whiteson K, Chow WA, Tinoco R, Moyers JT. PMID: 35474500; PMCID: PMC9042647.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Systemic Therapy for Chondrosarcoma. Curr Treat Options Oncol. 2022 Feb; 23(2):199-209.
Rock A, Ali S, Chow WA. PMID: 35190971.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Pazopanib in Patients with Osteosarcoma Metastatic to the Lung: Phase 2 Study Results and the Lessons for Tumor Measurement. J Oncol. 2022; 2022:3691025.
Frankel P, Ruel C, Uche A, Choy E, Okuno S, Somiah N, Chow WA. PMID: 35075361; PMCID: PMC8783732.
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PubMed Mentions:
5
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Clinical Activity of Single-Agent Cabozantinib (XL184), a Multi-receptor Tyrosine Kinase Inhibitor, in Patients with Refractory Soft-Tissue Sarcomas. Clin Cancer Res. 2022 01 15; 28(2):279-288.
O'Sullivan Coyne G, Kummar S, Hu J, Ganjoo K, Chow WA, Do KT, Zlott J, Bruns A, Rubinstein L, Foster JC, Juwara L, Meehan R, Piekarz R, Streicher H, Sharon E, Takebe N, Voth AR, Bottaro D, Costello R, Wright JJ, Doroshow JH, Chen AP. PMID: 34716194; PMCID: PMC8776602.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Single Protein Encapsulated Doxorubicin as an Efficacious Anticancer Therapeutic. Adv Ther (Weinh). 2020 Nov; 3(11).
Yu C, Huang F, Chow WA, Cook-Wiens G, Cui X. PMID: 33709014; PMCID: PMC7941910.
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PubMed Mentions:
3
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Recurrent secondary genomic alterations in desmoplastic small round cell tumors. BMC Med Genet. 2020 05 11; 21(1):101.
Chow WA, Yee JK, Tsark W, Wu X, Qin H, Guan M, Ross JS, Ali SM, Millis SZ. PMID: 32393201; PMCID: PMC7216377.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma. J Immunother Cancer. 2019 10 24; 7(1):276.
Ramachandran I, Lowther DE, Dryer-Minnerly R, Wang R, Fayngerts S, Nunez D, Betts G, Bath N, Tipping AJ, Melchiori L, Navenot JM, Glod J, Mackall CL, D'Angelo SP, Araujo DM, Chow WA, Demetri GD, Druta M, Van Tine BA, Grupp SA, Abdul Razak AR, Wilky B, Iyengar M, Trivedi T, Winkle EV, Chagin K, Amado R, Binder GK, Basu S. PMID: 31651363; PMCID: PMC6813983.
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PubMed Mentions:
76 Fields:
Translation:
HumansCells
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Chondrosarcoma: biology, genetics, and epigenetics. F1000Res. 2018; 7.
Chow WA. PMID: 30519452; PMCID: PMC6248264.
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PubMed Mentions:
43 Fields:
Translation:
Humans
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Association of Dasatinib With Progression-Free Survival Among Patients With Advanced Gastrointestinal Stromal Tumors Resistant to Imatinib. JAMA Oncol. 2018 06 01; 4(6):814-820.
Schuetze SM, Bolejack V, Thomas DG, von Mehren M, Patel S, Samuels B, Choy E, D'Amato G, Staddon AP, Ganjoo KN, Chow WA, Rushing DA, Forscher CA, Priebat DA, Loeb DM, Chugh R, Okuno S, Reinke DK, Baker LH. PMID: 29710216; PMCID: PMC6145709.
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PubMed Mentions:
13 Fields:
Translation:
HumansCTClinical Trials
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Fatty acid synthase reprograms the epigenome in uterine leiomyosarcomas. PLoS One. 2017; 12(6):e0179692.
Guan M, Wu X, Chu P, Chow WA. PMID: 28654693; PMCID: PMC5487038.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Clinical Cancer Advances 2017: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology. J Clin Oncol. 2017 04 20; 35(12):1341-1367.
Burstein HJ, Krilov L, Aragon-Ching JB, Baxter NN, Chiorean EG, Chow WA, De Groot JF, Devine SM, DuBois SG, El-Deiry WS, Epstein AS, Heymach J, Jones JA, Mayer DK, Miksad RA, Pennell NA, Sabel MS, Schilsky RL, Schuchter LM, Tung N, Winkfield KM, Wirth LJ, Dizon DS. PMID: 28148207.
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PubMed Mentions:
41 Fields:
Translation:
Humans
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Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor. Cancer. 2017 Jan 01; 123(1):90-97.
Schuetze SM, Bolejack V, Choy E, Ganjoo KN, Staddon AP, Chow WA, Tawbi HA, Samuels BL, Patel SR, von Mehren M, D'Amato G, Leu KM, Loeb DM, Forscher CA, Milhem MM, Rushing DA, Lucas DR, Chugh R, Reinke DK, Baker LH. PMID: 27696380.
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PubMed Mentions:
52 Fields:
Translation:
HumansCTClinical Trials
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Bones: The Adult Sarcoma Drama. J Oncol Pract. 2016 Mar; 12(3):219-20.
Chow WA. PMID: 26962162.
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Translation:
Humans
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SARC009: Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma. Cancer. 2016 Mar 15; 122(6):868-74.
Schuetze SM, Wathen JK, Lucas DR, Choy E, Samuels BL, Staddon AP, Ganjoo KN, von Mehren M, Chow WA, Loeb DM, Tawbi HA, Rushing DA, Patel SR, Thomas DG, Chugh R, Reinke DK, Baker LH. PMID: 26710211.
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PubMed Mentions:
48 Fields:
Translation:
HumansCTClinical Trials
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A randomised phase II trial of selumetinib vs selumetinib plus temsirolimus for soft-tissue sarcomas. Br J Cancer. 2015 May 12; 112(10):1644-51.
Eroglu Z, Tawbi HA, Hu J, Guan M, Frankel PH, Ruel NH, Wilczynski S, Christensen S, Gandara DR, Chow WA. PMID: 25897676; PMCID: PMC4430716.
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PubMed Mentions:
13 Fields:
Translation:
HumansCTClinical Trials
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Nelfinavir and nelfinavir analogs block site-2 protease cleavage to inhibit castration-resistant prostate cancer. Sci Rep. 2015 Apr 16; 5:9698.
Guan M, Su L, Yuan YC, Li H, Chow WA. PMID: 25880275; PMCID: PMC4816264.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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A phase 2 trial of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF-1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: results of a Sarcoma Alliance for Research Through Collaboration study. Cancer. 2014 Aug 15; 120(16):2448-56.
Pappo AS, Vassal G, Crowley JJ, Bolejack V, Hogendoorn PC, Chugh R, Ladanyi M, Grippo JF, Dall G, Staddon AP, Chawla SP, Maki RG, Araujo DM, Geoerger B, Ganjoo K, Marina N, Blay JY, Schuetze SM, Chow WA, Helman LJ. PMID: 24797726; PMCID: PMC7009782.
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PubMed Mentions:
103 Fields:
Translation:
HumansCTClinical Trials
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Complete pathologic response in soft tissue sarcoma lung metastases with pazopanib. J Thorac Oncol. 2014 Jan; 9(1):e4-6.
Eroglu Z, Kim J, Wilczynski S, Chow WA. PMID: 24346105.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Phase I study of nelfinavir in liposarcoma. Cancer Chemother Pharmacol. 2012 Dec; 70(6):791-9.
Pan J, Mott M, Xi B, Hepner E, Guan M, Fousek K, Magnusson R, Tinsley R, Valdes F, Frankel P, Synold T, Chow WA. PMID: 22983015; PMCID: PMC3904496.
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PubMed Mentions:
18 Fields:
Translation:
HumansCTClinical Trials
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Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer. FEBS J. 2012 Jul; 279(13):2399-411.
Guan M, Fousek K, Chow WA. PMID: 22540830.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Cutaneous metastasis of osteosarcoma in the scalp. Am J Dermatopathol. 2011 Aug; 33(6):e70-3.
Ragsdale MI, Lehmer LM, Ragsdale BD, Chow WA, Carson RT. PMID: 21778830.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6. Clin Cancer Res. 2011 Apr 01; 17(7):1796-806.
Guan M, Fousek K, Jiang C, Guo S, Synold T, Xi B, Shih CC, Chow WA. PMID: 21355074.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Novel targeted therapies in the treatment of soft-tissue sarcomas. Expert Rev Anticancer Ther. 2010 Aug; 10(8):1303-11.
Chao J, Chow WA, Somlo G. PMID: 20735315.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Phase II clinical trial of imatinib mesylate in therapy of KIT and/or PDGFRalpha-expressing Ewing sarcoma family of tumors and desmoplastic small round cell tumors. Anticancer Res. 2010 Feb; 30(2):547-52.
Chao J, Budd GT, Chu P, Frankel P, Garcia D, Junqueira M, Loera S, Somlo G, Sato J, Chow WA. PMID: 20332468.
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PubMed Mentions:
27 Fields:
Translation:
HumansCTClinical Trials
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Tandem high-dose chemotherapy followed by autologous transplantation in patients with locally advanced or metastatic sarcoma. Anticancer Res. 2009 Aug; 29(8):3281-8.
Lashkari A, Chow WA, Valdes F, Leong L, Phan V, Twardowski P, Kapoor N, Molina A, Al-Kadhimi Z, Frankel P, Somlo G. PMID: 19661346.
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PubMed Mentions:
8 Fields:
Translation:
HumansCTClinical Trials
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Phase I trial of GTI-2040, oxaliplatin, and capecitabine in the treatment of advanced metastatic solid tumors: a California Cancer Consortium Study. Cancer Chemother Pharmacol. 2009 Nov; 64(6):1149-55.
Shibata SI, Doroshow JH, Frankel P, Synold TW, Yen Y, Gandara DR, Lenz HJ, Chow WA, Leong LA, Lim D, Margolin KA, Morgan RJ, Somlo G, Newman EM. PMID: 19322566; PMCID: PMC3046108.
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PubMed Mentions:
6 Fields:
Translation:
HumansCellsCTClinical Trials
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Anti-HIV drugs for cancer therapeutics: back to the future? Lancet Oncol. 2009 Jan; 10(1):61-71.
Chow WA, Jiang C, Guan M. PMID: 19111246.
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PubMed Mentions:
80 Fields:
Translation:
Humans
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Update on chondrosarcomas. Curr Opin Oncol. 2007 Jul; 19(4):371-6.
Chow WA. PMID: 17545802.
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PubMed Mentions:
36 Fields:
Translation:
HumansCells
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Nelfinavir induces liposarcoma apoptosis and cell cycle arrest by upregulating sterol regulatory element binding protein-1. Anticancer Drugs. 2006 Sep; 17(8):891-903.
Chow WA, Guo S, Valdes-Albini F. PMID: 16940799.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas. Cancer Genet Cytogenet. 2006 Apr 15; 166(2):95-100.
Chow WA, Bedell V, Gaytan P, Borden E, Goldblum J, Hicks D, Slovak ML. PMID: 16631464.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies. Eur J Surg Oncol. 2004 Aug; 30(6):650-7.
Shibata SI, Pezner R, Chu D, Doroshow JH, Chow WA, Leong LA, Margolin KA, McNamara MV, Morgan RJ, Raschko JW, Somlo G, Tetef ML, Yen Y, Synold TW, Wagman L, Vora N, Carroll M, Lin S, Longmate J. PMID: 15256240.
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Translation:
Humans
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Feasibility and pharmacokinetic study of infusional dexrazoxane and dose-intensive doxorubicin administered concurrently over 96 h for the treatment of advanced malignancies. Cancer Chemother Pharmacol. 2004 Sep; 54(3):241-8.
Chow WA, Synold TW, Tetef ML, Longmate J, Frankel P, Lawrence J, Al-Khadimi Z, Leong L, Lim D, Margolin K, Morgan RJ, Raschko J, Shibata S, Somlo G, Twardowski P, Yen Y, Doroshow JH. PMID: 15173955.
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PubMed Mentions:
3 Fields:
Translation:
HumansCTClinical Trials
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The IFN regulatory factor family participates in regulation of Fas ligand gene expression in T cells. J Immunol. 2000 Apr 01; 164(7):3512-8.
Chow WA, Fang JJ, Yee JK. PMID: 10725705.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Soft tissue masses of the chest wall and axilla: has metastatic melanoma been considered? Am J Clin Oncol. 1999 Apr; 22(2):174-7.
Schwarz RE, Chow WA, Andersen JS, Arber DA, Balch CM. PMID: 10199454.
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PubMed Mentions: Fields:
Translation:
Humans
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Unusual interactions between cleavage products of a cis-cleaving hammerhead ribozyme. Antisense Nucleic Acid Drug Dev. 1998 Dec; 8(6):499-506.
Castanotto D, Chow WA, Li H, Rossi JJ. PMID: 9918114.
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PubMed Mentions:
1 Fields:
Translation:
Cells