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Advanced glycation end-product crosslinking activates a type VI secretion system phospholipase effector protein. Nat Commun. 2024 Oct 11; 15(1):8804.
Jensen SJ, Cuthbert BJ, Garza-Sánchez F, Helou CC, de Miranda R, Goulding CW, Hayes CS. PMID: 39394186; PMCID: PMC11470151.
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Cells
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The structure of Mycobacterium thermoresistibile MmpS5 reveals a conserved disulfide bond across mycobacteria. Metallomics. 2024 03 12; 16(3).
Cuthbert BJ, Mendoza J, de Miranda R, Papavinasasundaram K, Sassetti CM, Goulding CW. PMID: 38425033; PMCID: PMC10929441.
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PubMed Mentions: Fields:
Translation:
HumansCellsPHPublic Health
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Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake. PLoS Pathog. 2023 09; 19(9):e1011650.
de Miranda R, Cuthbert BJ, Klevorn T, Chao A, Mendoza J, Arbing M, Sieminski PJ, Papavinasasundaram K, Abdul-Hafiz S, Chan S, Sassetti CM, Ehrt S, Goulding CW. PMID: 37747938; PMCID: PMC10553834.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Label-free affinity screening, design and synthesis of inhibitors targeting the Mycobacterium tuberculosis L-alanine dehydrogenase. PLoS One. 2022; 17(11):e0277670.
Kim HB, Bacik JP, Wu R, Jha RK, Hebron M, Triandafillou C, McCown JE, Baek NI, Kim JH, Kim YJ, Goulding CW, Strauss CEM, Schmidt JG, Shetye GS, Ryoo S, Jo EK, Jeon YH, Hung LW, Terwilliger TC, Kim CY. PMID: 36395154; PMCID: PMC9671377.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Author Correction: Proteolytic processing induces a conformational switch required for antibacterial toxin delivery. Nat Commun. 2022 Oct 21; 13(1):6251.
Bartelli NL, Passanisi VJ, Michalska K, Song K, Nhan DQ, Zhou H, Cuthbert BJ, Stols LM, Eschenfeldt WH, Wilson NG, Basra JS, Cortes R, Noorsher Z, Gabraiel Y, Poonen-Honig I, Seacord EC, Goulding CW, Low DA, Joachimiak A, Dahlquist FW, Hayes CS. PMID: 36271082; PMCID: PMC9587248.
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PubMed Mentions: Fields:
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Proteolytic processing induces a conformational switch required for antibacterial toxin delivery. Nat Commun. 2022 08 29; 13(1):5078.
Bartelli NL, Passanisi VJ, Michalska K, Song K, Nhan DQ, Zhou H, Cuthbert BJ, Stols LM, Eschenfeldt WH, Wilson NG, Basra JS, Cortes R, Noorsher Z, Gabraiel Y, Poonen-Honig I, Seacord EC, Goulding CW, Low DA, Joachimiak A, Dahlquist FW, Hayes CS. PMID: 36038560; PMCID: PMC9424206.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Functional and Structural Diversity of Bacterial Contact-Dependent Growth Inhibition Effectors. Front Mol Biosci. 2022; 9:866854.
Cuthbert BJ, Hayes CS, Goulding CW. PMID: 35558562; PMCID: PMC9086364.
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PubMed Mentions:
7
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Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis. Mol Syst Biol. 2021 05; 17(5):e10280.
Borah K, Mendum TA, Hawkins ND, Ward JL, Beale MH, Larrouy-Maumus G, Bhatt A, Moulin M, Haertlein M, Strohmeier G, Pichler H, Forsyth VT, Noack S, Goulding CW, McFadden J, Beste DJV. PMID: 33943004; PMCID: PMC8094261.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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Structural and Molecular Dynamics of Mycobacterium tuberculosis Malic Enzyme, a Potential Anti-TB Drug Target. ACS Infect Dis. 2021 01 08; 7(1):174-188.
Burley KH, Cuthbert BJ, Basu P, Newcombe J, Irimpan EM, Quechol R, Foik IP, Mobley DL, Beste DJV, Goulding CW. PMID: 33356117; PMCID: PMC8083904.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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An optimized chemical-genetic method for cell-specific metabolic labeling of RNA. Nat Methods. 2020 03; 17(3):311-318.
Nainar S, Cuthbert BJ, Lim NM, England WE, Ke K, Sophal K, Quechol R, Mobley DL, Goulding CW, Spitale RC. PMID: 32015544; PMCID: PMC8518020.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Correction to "A Single Mutation in the Mycobacterium tuberculosis Heme-Degrading Protein, MhuD, Results in Different Products". Biochemistry. 2020 Feb 18; 59(6):829.
Chao A, Goulding CW. PMID: 31999434.
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PubMed Mentions: Fields:
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Structure of a Mycobacterium tuberculosis Heme-Degrading Protein, MhuD, Variant in Complex with Its Product. Biochemistry. 2019 11 19; 58(46):4610-4620.
Chao A, Burley KH, Sieminski PJ, de Miranda R, Chen X, Mobley DL, Goulding CW. PMID: 31638374; PMCID: PMC7045704.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins. Structure. 2019 11 05; 27(11):1660-1674.e5.
Gucinski GC, Michalska K, Garza-Sánchez F, Eschenfeldt WH, Stols L, Nguyen JY, Goulding CW, Joachimiak A, Hayes CS. PMID: 31515004; PMCID: PMC6834915.
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PubMed Mentions:
16 Fields:
Translation:
Cells
-
Target highlights in CASP13: Experimental target structures through the eyes of their authors. Proteins. 2019 12; 87(12):1037-1057.
Lepore R, Kryshtafovych A, Alahuhta M, Veraszto HA, Bomble YJ, Bufton JC, Bullock AN, Caba C, Cao H, Davies OR, Desfosses A, Dunne M, Fidelis K, Goulding CW, Gurusaran M, Gutsche I, Harding CJ, Hartmann MD, Hayes CS, Joachimiak A, Leiman PG, Loppnau P, Lovering AL, Lunin VV, Michalska K, Mir-Sanchis I, Mitra AK, Moult J, Phillips GN, Pinkas DM, Rice PA, Tong Y, Topf M, Walton JD, Schwede T. PMID: 31442339; PMCID: PMC6851490.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1. Microbiol Spectr. 2019 05; 7(3).
Tiwari S, Casey R, Goulding CW, Hingley-Wilson S, Jacobs WR. PMID: 31172908; PMCID: PMC6698389.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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A Single Mutation in the Mycobacterium tuberculosis Heme-Degrading Protein, MhuD, Results in Different Products. Biochemistry. 2019 02 12; 58(6):489-492.
Chao A, Goulding CW. PMID: 30605595; PMCID: PMC6568316.
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PubMed Mentions:
8 Fields:
Translation:
Cells
-
Iron Acquisition in Mycobacterium tuberculosis. Chem Rev. 2019 01 23; 119(2):1193-1220.
Chao A, Sieminski PJ, Owens CP, Goulding CW. PMID: 30474981; PMCID: PMC6568009.
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PubMed Mentions:
45 Fields:
Translation:
HumansCells
-
The affinity of MhuD for heme is consistent with a heme degrading function in vivo. Metallomics. 2018 11 14; 10(11):1560-1563.
Thakuri B, Graves AB, Chao A, Johansen SL, Goulding CW, Liptak MD. PMID: 30239544; PMCID: PMC6529808.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Functional plasticity of antibacterial EndoU toxins. Mol Microbiol. 2018 08; 109(4):509-527.
Michalska K, Quan Nhan D, Willett JLE, Stols LM, Eschenfeldt WH, Jones AM, Nguyen JY, Koskiniemi S, Low DA, Goulding CW, Joachimiak A, Hayes CS. PMID: 29923643; PMCID: PMC6173971.
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PubMed Mentions:
20 Fields:
Translation:
Cells
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Introducing the new bacterial branch of the RNase A superfamily. RNA Biol. 2018 01 02; 15(1):9-12.
Cuthbert BJ, Burley KH, Goulding CW. PMID: 29099294; PMCID: PMC5786019.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016). Proteins. 2018 03; 86 Suppl 1:27-50.
Kryshtafovych A, Albrecht R, Baslé A, Bule P, Caputo AT, Carvalho AL, Chao KL, Diskin R, Fidelis K, Fontes CMGA, Fredslund F, Gilbert HJ, Goulding CW, Hartmann MD, Hayes CS, Herzberg O, Hill JC, Joachimiak A, Kohring GW, Koning RI, Lo Leggio L, Mangiagalli M, Michalska K, Moult J, Najmudin S, Nardini M, Nardone V, Ndeh D, Nguyen TH, Pintacuda G, Postel S, van Raaij MJ, Roversi P, Shimon A, Singh AK, Sundberg EJ, Tars K, Zitzmann N, Schwede T. PMID: 28960539; PMCID: PMC5820184.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Structure of a novel antibacterial toxin that exploits elongation factor Tu to cleave specific transfer RNAs. Nucleic Acids Res. 2017 Sep 29; 45(17):10306-10320.
Michalska K, Gucinski GC, Garza-Sánchez F, Johnson PM, Stols LM, Eschenfeldt WH, Babnigg G, Low DA, Goulding CW, Joachimiak A, Hayes CS. PMID: 28973472; PMCID: PMC5737660.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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From B to A: making an essential cofactor in a human parasite. Biochem J. 2017 08 30; 474(18):3089-3092.
Morrissette NS, Goulding CW. PMID: 28860337.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Protein engineering: Redirecting membrane machinery. Nat Chem Biol. 2017 08 18; 13(9):927-928.
Burley K, Goulding CW. PMID: 28820876.
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PubMed Mentions: Fields:
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The CDI toxin of Yersinia kristensenii is a novel bacterial member of the RNase A superfamily. Nucleic Acids Res. 2017 May 19; 45(9):5013-5025.
Batot G, Michalska K, Ekberg G, Irimpan EM, Joachimiak G, Jedrzejczak R, Babnigg G, Hayes CS, Joachimiak A, Goulding CW. PMID: 28398546; PMCID: PMC5435912.
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PubMed Mentions:
18 Fields:
Translation:
Cells
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Progress toward the Development of a NEAT Protein Vaccine for Anthrax Disease. Infect Immun. 2016 Dec; 84(12):3408-3422.
Balderas MA, Nguyen CT, Terwilliger A, Keitel WA, Iniguez A, Torres R, Palacios F, Goulding CW, Maresso AW. PMID: 27647868; PMCID: PMC5116719.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes. mBio. 2016 10 25; 7(5).
Costa DL, Namasivayam S, Amaral EP, Arora K, Chao A, Mittereder LR, Maiga M, Boshoff HI, Barry CE, Goulding CW, Andrade BB, Sher A. PMID: 27795400; PMCID: PMC5080384.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
Unraveling the essential role of CysK in CDI toxin activation. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9792-7.
Johnson PM, Beck CM, Morse RP, Garza-Sánchez F, Low DA, Hayes CS, Goulding CW. PMID: 27531961; PMCID: PMC5024621.
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PubMed Mentions:
33 Fields:
Translation:
Cells
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Functional Diversity of Cytotoxic tRNase/Immunity Protein Complexes from Burkholderia pseudomallei. J Biol Chem. 2016 09 09; 291(37):19387-400.
Johnson PM, Gucinski GC, Garza-Sánchez F, Wong T, Hung LW, Hayes CS, Goulding CW. PMID: 27445337; PMCID: PMC5016678.
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PubMed Mentions:
22 Fields:
Translation:
Cells
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Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration. Cell Host Microbe. 2016 Jun 08; 19(6):814-25.
Diaz-Ochoa VE, Lam D, Lee CS, Klaus S, Behnsen J, Liu JZ, Chim N, Nuccio SP, Rathi SG, Mastroianni JR, Edwards RA, Jacobo CM, Cerasi M, Battistoni A, Ouellette AJ, Goulding CW, Chazin WJ, Skaar EP, Raffatellu M. PMID: 27281571; PMCID: PMC4901528.
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PubMed Mentions:
76 Fields:
Translation:
AnimalsCells
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Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):3779-84.
Matsui T, Nambu S, Goulding CW, Takahashi S, Fujii H, Ikeda-Saito M. PMID: 27006503; PMCID: PMC4833273.
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PubMed Mentions:
19 Fields:
Translation:
Cells
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Diversification of β-Augmentation Interactions between CDI Toxin/Immunity Proteins. J Mol Biol. 2015 Nov 20; 427(23):3766-84.
Morse RP, Willett JL, Johnson PM, Zheng J, Credali A, Iniguez A, Nowick JS, Hayes CS, Goulding CW. PMID: 26449640; PMCID: PMC4658667.
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PubMed Mentions:
23 Fields:
Translation:
Cells
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Contact-Dependent Growth Inhibition (CDI) and CdiB/CdiA Two-Partner Secretion Proteins. J Mol Biol. 2015 Nov 20; 427(23):3754-65.
Willett JL, Ruhe ZC, Goulding CW, Low DA, Hayes CS. PMID: 26388411; PMCID: PMC4658273.
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PubMed Mentions:
59 Fields:
Translation:
Cells
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The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis. Chem Biol. 2015 Aug 20; 22(8):1098-107.
Chim N, Torres R, Liu Y, Capri J, Batot G, Whitelegge JP, Goulding CW. PMID: 26278184; PMCID: PMC4546533.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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Fe(2+) substrate transport through ferritin protein cage ion channels influences enzyme activity and biomineralization. J Biol Inorg Chem. 2015 Sep; 20(6):957-69.
Behera RK, Torres R, Tosha T, Bradley JM, Goulding CW, Theil EC. PMID: 26202907; PMCID: PMC4634868.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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The structure of a contact-dependent growth-inhibition (CDI) immunity protein from Neisseria meningitidis MC58. Acta Crystallogr F Struct Biol Commun. 2015 Jun; 71(Pt 6):702-9.
Tan K, Johnson PM, Stols L, Boubion B, Eschenfeldt W, Babnigg G, Hayes CS, Joachimiak A, Goulding CW. PMID: 26057799; PMCID: PMC4461334.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Crystallographic and spectroscopic insights into heme degradation by Mycobacterium tuberculosis MhuD. Inorg Chem. 2014 Jun 16; 53(12):5931-40.
Graves AB, Morse RP, Chao A, Iniguez A, Goulding CW, Liptak MD. PMID: 24901029; PMCID: PMC4060609.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Characterization of a Mycobacterium tuberculosis nanocompartment and its potential cargo proteins. J Biol Chem. 2014 Jun 27; 289(26):18279-89.
Contreras H, Joens MS, McMath LM, Le VP, Tullius MV, Kimmey JM, Bionghi N, Horwitz MA, Fitzpatrick JA, Goulding CW. PMID: 24855650; PMCID: PMC4140288.
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PubMed Mentions:
43 Fields:
Translation:
Cells
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Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase. Acta Crystallogr D Biol Crystallogr. 2014 Apr; 70(Pt 4):1074-85.
Torres R, Lan B, Latif Y, Chim N, Goulding CW. PMID: 24699651; PMCID: PMC3975890.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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CdiA from Enterobacter cloacae delivers a toxic ribosomal RNase into target bacteria. Structure. 2014 May 06; 22(5):707-18.
Beck CM, Morse RP, Cunningham DA, Iniguez A, Low DA, Goulding CW, Hayes CS. PMID: 24657090; PMCID: PMC4016183.
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PubMed Mentions:
51 Fields:
Translation:
Cells
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Heme uptake in bacterial pathogens. Curr Opin Chem Biol. 2014 Apr; 19:34-41.
Contreras H, Chim N, Credali A, Goulding CW. PMID: 24780277; PMCID: PMC4007353.
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PubMed Mentions:
64 Fields:
Translation:
HumansCells
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Insights into redox sensing metalloproteins in Mycobacterium tuberculosis. J Inorg Biochem. 2014 Apr; 133:118-26.
Chim N, Johnson PM, Goulding CW. PMID: 24314844; PMCID: PMC3959581.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Structural and biochemical characterization of the essential DsbA-like disulfide bond forming protein from Mycobacterium tuberculosis. BMC Struct Biol. 2013 Oct 18; 13:23.
Chim N, Harmston CA, Guzman DJ, Goulding CW. PMID: 24134223; PMCID: PMC3853704.
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PubMed Mentions:
17 Fields:
Translation:
Cells
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Structures of oligomers of a peptide from β-amyloid. J Am Chem Soc. 2013 Aug 21; 135(33):12460-7.
Pham JD, Chim N, Goulding CW, Nowick JS. PMID: 23927812; PMCID: PMC3787202.
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PubMed Mentions:
19 Fields:
Translation:
Cells
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Insights on how the Mycobacterium tuberculosis heme uptake pathway can be used as a drug target. Future Med Chem. 2013 Aug; 5(12):1391-403.
Owens CP, Chim N, Goulding CW. PMID: 23919550; PMCID: PMC3838433.
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PubMed Mentions:
28 Fields:
Translation:
Cells
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The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11. J Biol Chem. 2013 Jul 26; 288(30):21714-28.
Owens CP, Chim N, Graves AB, Harmston CA, Iniguez A, Contreras H, Liptak MD, Goulding CW. PMID: 23760277; PMCID: PMC3724630.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Heme degradation by Staphylococcus aureus IsdG and IsdI liberates formaldehyde rather than carbon monoxide. Biochemistry. 2013 May 07; 52(18):3025-7.
Matsui T, Nambu S, Ono Y, Goulding CW, Tsumoto K, Ikeda-Saito M. PMID: 23600533; PMCID: PMC3672231.
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PubMed Mentions:
43 Fields:
Translation:
Cells
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A new way to degrade heme: the Mycobacterium tuberculosis enzyme MhuD catalyzes heme degradation without generating CO. J Biol Chem. 2013 Apr 05; 288(14):10101-10109.
Nambu S, Matsui T, Goulding CW, Takahashi S, Ikeda-Saito M. PMID: 23420845; PMCID: PMC3617252.
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PubMed Mentions:
61 Fields:
Translation:
Cells
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The near-iron transporter (NEAT) domains of the anthrax hemophore IsdX2 require a critical glutamine to extract heme from methemoglobin. J Biol Chem. 2013 Mar 22; 288(12):8479-8490.
Honsa ES, Owens CP, Goulding CW, Maresso AW. PMID: 23364793; PMCID: PMC3605663.
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PubMed Mentions:
16 Fields:
Translation:
Cells
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Structural basis of toxicity and immunity in contact-dependent growth inhibition (CDI) systems. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21480-5.
Morse RP, Nikolakakis KC, Willett JL, Gerrick E, Low DA, Hayes CS, Goulding CW. PMID: 23236156; PMCID: PMC3535622.
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PubMed Mentions:
71 Fields:
Translation:
Cells
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Differential function of lip residues in the mechanism and biology of an anthrax hemophore. PLoS Pathog. 2012; 8(3):e1002559.
Ekworomadu MT, Poor CB, Owens CP, Balderas MA, Fabian M, Olson JS, Murphy F, Bakkalbasi E, Balkabasi E, Honsa ES, He C, Goulding CW, Maresso AW. PMID: 22412371; PMCID: PMC3297588.
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PubMed Mentions:
25 Fields:
Translation:
Cells
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Characterization of heme ligation properties of Rv0203, a secreted heme binding protein involved in Mycobacterium tuberculosis heme uptake. Biochemistry. 2012 Feb 21; 51(7):1518-31.
Owens CP, Du J, Dawson JH, Goulding CW. PMID: 22283334; PMCID: PMC3299815.
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PubMed Mentions:
36 Fields:
Translation:
HumansCells
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Structural insights into RipC, a putative citrate lyase β subunit from a Yersinia pestis virulence operon. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jan 01; 68(Pt 1):2-7.
Torres R, Chim N, Sankaran B, Pujol C, Bliska JB, Goulding CW. PMID: 22232161; PMCID: PMC3253824.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Plasma antibody profiles as diagnostic biomarkers for tuberculosis. Clin Vaccine Immunol. 2011 Dec; 18(12):2148-53.
Khan IH, Ravindran R, Krishnan VV, Awan IN, Rizvi SK, Saqib MA, Shahzad MI, Tahseen S, Ireton G, Goulding CW, Felgner P, DeRiemer K, Khanum A, Luciw PA. PMID: 21976221; PMCID: PMC3232686.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis. PLoS One. 2011; 6(9):e25084.
Torres R, Swift RV, Chim N, Wheatley N, Lan B, Atwood BR, Pujol C, Sankaran B, Bliska JB, Amaro RE, Goulding CW. PMID: 21966419; PMCID: PMC3180442.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Discovery and characterization of a unique mycobacterial heme acquisition system. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5051-6.
Tullius MV, Harmston CA, Owens CP, Chim N, Morse RP, McMath LM, Iniguez A, Kimmey JM, Sawaya MR, Whitelegge JP, Horwitz MA, Goulding CW. PMID: 21383189; PMCID: PMC3064333.
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PubMed Mentions:
107 Fields:
Translation:
Cells
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The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinb). 2011 Mar; 91(2):155-72.
Chim N, Habel JE, Johnston JM, Krieger I, Miallau L, Sankaranarayanan R, Morse RP, Bruning J, Swanson S, Kim H, Kim CY, Li H, Bulloch EM, Payne RJ, Manos-Turvey A, Hung LW, Baker EN, Lott JS, James MN, Terwilliger TC, Eisenberg DS, Sacchettini JC, Goulding CW. PMID: 21247804; PMCID: PMC3310434.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Crystallization and preliminary X-ray crystallographic analysis of a Mycobacterium tuberculosis ferritin homolog, BfrB. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 01; 66(Pt 12):1657-61.
McMath LM, Habel JE, Sankaran B, Yu M, Hung LW, Goulding CW. PMID: 21139218; PMCID: PMC2998377.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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An extracellular disulfide bond forming protein (DsbF) from Mycobacterium tuberculosis: structural, biochemical, and gene expression analysis. J Mol Biol. 2010 Mar 12; 396(5):1211-26.
Chim N, Riley R, The J, Im S, Segelke B, Lekin T, Yu M, Hung LW, Terwilliger T, Whitelegge JP, Goulding CW. PMID: 20060836; PMCID: PMC2883863.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Unusual diheme conformation of the heme-degrading protein from Mycobacterium tuberculosis. J Mol Biol. 2010 Jan 22; 395(3):595-608.
Chim N, Iniguez A, Nguyen TQ, Goulding CW. PMID: 19917297; PMCID: PMC2859679.
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PubMed Mentions:
59 Fields:
Translation:
Cells
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Advances in Mycobacterium tuberculosis structural genomics: investigating potential chinks in the armor of a deadly pathogen. Infect Disord Drug Targets. 2009 Nov; 9(5):475-92.
Chim N, McMath LM, Beeby M, Goulding CW. PMID: 19594421.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Structural genomics: from genes to structures with valuable materials and many questions in between. Nat Methods. 2008 Feb; 5(2):129-32.
Fox BG, Goulding C, Malkowski MG, Stewart L, Deacon A. PMID: 18235432.
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PubMed Mentions:
26 Fields:
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Profiling antibodies to Mycobacterium tuberculosis by multiplex microbead suspension arrays for serodiagnosis of tuberculosis. Clin Vaccine Immunol. 2008 Mar; 15(3):433-8.
Khan IH, Ravindran R, Yee J, Ziman M, Lewinsohn DM, Gennaro ML, Flynn JL, Goulding CW, DeRiemer K, Lerche NW, Luciw PA. PMID: 18077619; PMCID: PMC2268277.
View in:
PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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High throughput crystallography of TB drug targets. Infect Disord Drug Targets. 2007 Jun; 7(2):127-39.
Murillo AC, Li HY, Alber T, Baker EN, Berger JM, Cherney LT, Cherney MM, Cho YS, Eisenberg D, Garen CR, Goulding CW, Hung LW, Ioerger TR, Jacobs WR, James MN, Kim C, Krieger I, Lott JS, Sankaranarayanan R, Segelke BW, Terwilliger TC, Wang F, Wang S, Sacchettini JC. PMID: 17970224.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase. J Biomol Screen. 2007 Feb; 12(1):100-5.
White EL, Southworth K, Ross L, Cooley S, Gill RB, Sosa MI, Manouvakhova A, Rasmussen L, Goulding C, Eisenberg D, Fletcher TM. PMID: 17175524.
View in:
PubMed Mentions:
26 Fields:
Translation:
Cells
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The structure and computational analysis of Mycobacterium tuberculosis protein CitE suggest a novel enzymatic function. J Mol Biol. 2007 Jan 12; 365(2):275-83.
Goulding CW, Bowers PM, Segelke B, Lekin T, Kim CY, Terwilliger TC, Eisenberg D. PMID: 17064730.
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20 Fields:
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Structural proteomics and computational analysis of a deadly pathogen: combating Mycobacterium tuberculosis from multiple fronts. Methods Biochem Anal. 2006; 49:245-69.
Strong M, Goulding CW. PMID: 16929683.
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1 Fields:
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Cells
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Regulation by oligomerization in a mycobacterial folate biosynthetic enzyme. J Mol Biol. 2005 May 27; 349(1):61-72.
Goulding CW, Apostol MI, Sawaya MR, Phillips M, Parseghian A, Eisenberg D. PMID: 15876368.
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21 Fields:
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Cells
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Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis. J Biol Chem. 2004 Jan 30; 279(5):3516-24.
Goulding CW, Apostol MI, Gleiter S, Parseghian A, Bardwell J, Gennaro M, Eisenberg D. PMID: 14597624.
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28 Fields:
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Cells
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The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12420-5.
Hsu T, Hingley-Wilson SM, Chen B, Chen M, Dai AZ, Morin PM, Marks CB, Padiyar J, Goulding C, Gingery M, Eisenberg D, Russell RG, Derrick SC, Collins FM, Morris SL, King CH, Jacobs WR. PMID: 14557547; PMCID: PMC218773.
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363 Fields:
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HumansAnimalsCells
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Structural genomics of Mycobacterium tuberculosis: a preliminary report of progress at UCLA. Biophys Chem. 2003 Sep; 105(2-3):361-70.
Goulding CW, Perry LJ, Anderson D, Sawaya MR, Cascio D, Apostol MI, Chan S, Parseghian A, Wang SS, Wu Y, Cassano V, Gill HS, Eisenberg D. PMID: 14499904.
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PubMed Mentions:
10 Fields:
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Cells
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Protein production in Escherichia coli for structural studies by X-ray crystallography. J Struct Biol. 2003 Apr; 142(1):133-43.
Goulding CW, Perry LJ. PMID: 12718925.
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22 Fields:
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Cells
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The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology. Tuberculosis (Edinb). 2003; 83(4):223-49.
Terwilliger TC, Park MS, Waldo GS, Berendzen J, Hung LW, Kim CY, Smith CV, Sacchettini JC, Bellinzoni M, Bossi R, De Rossi E, Mattevi A, Milano A, Riccardi G, Rizzi M, Roberts MM, Coker AR, Fossati G, Mascagni P, Coates AR, Wood SP, Goulding CW, Apostol MI, Anderson DH, Gill HS, Eisenberg DS, Taneja B, Mande S, Pohl E, Lamzin V, Tucker P, Wilmanns M, Colovos C, Meyer-Klaucke W, Munro AW, McLean KJ, Marshall KR, Leys D, Yang JK, Yoon HJ, Lee BI, Lee MG, Kwak JE, Han BW, Lee JY, Baek SH, Suh SW, Komen MM, Arcus VL, Baker EN, Lott JS, Jacobs W, Alber T, Rupp B. PMID: 12906835.
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24 Fields:
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HumansCells
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Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-A resolution. Protein Sci. 2002 Dec; 11(12):2887-93.
Goulding CW, Parseghian A, Sawaya MR, Cascio D, Apostol MI, Gennaro ML, Eisenberg D. PMID: 12441386; PMCID: PMC2373750.
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PubMed Mentions:
10 Fields:
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Cells
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Thiol-disulfide exchange in an immunoglobulin-like fold: structure of the N-terminal domain of DsbD. Biochemistry. 2002 Jun 04; 41(22):6920-7.
Goulding CW, Sawaya MR, Parseghian A, Lim V, Eisenberg D, Missiakas D. PMID: 12033924.
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24 Fields:
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Cells
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The TB structural genomics consortium: providing a structural foundation for drug discovery. Curr Drug Targets Infect Disord. 2002 Jun; 2(2):121-41.
Goulding CW, Apostol M, Anderson DH, Gill HS, Smith CV, Kuo MR, Yang JK, Waldo GS, Suh SW, Chauhan R, Kale A, Bachhawat N, Mande SC, Johnston JM, Lott JS, Baker EN, Arcus VL, Leys D, McLean KJ, Munro AW, Berendzen J, Sharma V, Park MS, Eisenberg D, Sacchettini J, Alber T, Rupp B, Jacobs W, Terwilliger TC. PMID: 12462144.
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17 Fields:
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Cells
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Evaluation of BioStar FLU OIA assay for rapid detection of influenza A and B viruses in respiratory specimens. J Clin Virol. 2000 Aug; 17(2):119-26.
Hindiyeh M, Goulding C, Morgan H, Kenyon B, Langer J, Fox L, Dean G, Woolstenhulme D, Turnbow A, Billetdeaux E, Shakib S, Gordon C, Powers A, Vardeny G, Johnson M, Skodack-Jones L, Carroll K. PMID: 10942092.
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PubMed Mentions:
17 Fields:
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HumansAnimalsCells
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Cobalamin-dependent methionine synthase from Escherichia coli: involvement of zinc in homocysteine activation. Biochemistry. 1997 Dec 16; 36(50):15749-57.
Goulding CW, Matthews RG. PMID: 9398304.
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18 Fields:
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Cells
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Enzyme-catalyzed methyl transfers to thiols: the role of zinc. Curr Opin Chem Biol. 1997 Oct; 1(3):332-9.
Matthews RG, Goulding CW. PMID: 9667865.
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PubMed Mentions:
28 Fields:
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Cells
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Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine. Biochemistry. 1997 Jul 01; 36(26):8082-91.
Goulding CW, Postigo D, Matthews RG. PMID: 9201956.
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PubMed Mentions:
42 Fields:
Translation:
Cells