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Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity. Nat Commun. 2023 Apr 27; 14(1):2413.
Nguyen K, Malik TN, Chaput JC. PMID: 37105964; PMCID: PMC10140269.
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PubMed Mentions: Fields:
Translation:
Cells
-
Amplification-Free COVID-19 Detection by Digital Droplet REVEALR. ACS Synth Biol. 2023 Mar 22.
Yang K, Chaput JC. PMID: 36947677; PMCID: PMC10042143.
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PubMed Mentions: Fields:
Translation:
HumansCellsPHPublic Health
-
Metabolic adjustments in response to ATP spilling by the small DX protein in a Streptomyces strain. Front Cell Dev Biol. 2023; 11:1129009.
Apel C, Levasseur M, Lejeune C, Korch SB, Gu?rard F, David M, Askora A, Litaudon M, Roussi F, Gaki?re B, Chaput J, Virolle MJ. PMID: 36968208; PMCID: PMC10030506.
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PubMed Mentions:
-
Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid. Nucleic Acids Res. 2022 09 23; 50(17):9663-9674.
Hajjar M, Chim N, Liu C, Herdewijn P, Chaput JC. PMID: 36124684; PMCID: PMC9508818.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
-
Reply to: On gene silencing by the X10-23 DNAzyme. Nat Chem. 2022 08; 14(8):859-861.
Spitale RC, Chaput JC. PMID: 35851838.
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PubMed Mentions:
1 Fields:
-
REVEALR-Based Genotyping of SARS-CoV-2 Variants of Concern in Clinical Samples. J Am Chem Soc. 2022 07 06; 144(26):11685-11692.
Yang K, Schuder DN, Ngor AK, Chaput JC. PMID: 35729726; PMCID: PMC9236216.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Transliteration of synthetic genetic enzymes. Nucleic Acids Res. 2021 11 18; 49(20):11438-11446.
Wang Y, Liu X, Shehabat M, Chim N, Chaput JC. PMID: 34634814; PMCID: PMC8599711.
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PubMed Mentions:
1 Fields:
-
Evolution of Functionally Enhanced α-l-Threofuranosyl Nucleic Acid Aptamers. ACS Synth Biol. 2021 11 19; 10(11):3190-3199.
McCloskey CM, Li Q, Yik EJ, Chim N, Ngor AK, Medina E, Grubisic I, Co Ting Keh L, Poplin R, Chaput JC. PMID: 34739228.
View in:
PubMed Mentions:
9 Fields:
-
Synthesis and Polymerase Recognition of Threose Nucleic Acid Triphosphates Equipped with Diverse Chemical Functionalities. J Am Chem Soc. 2021 10 27; 143(42):17761-17768.
Li Q, Maola VA, Chim N, Hussain J, Lozoya-Colinas A, Chaput JC. PMID: 34637287.
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PubMed Mentions:
7 Fields:
Translation:
Cells
-
REVEALR: A Multicomponent XNAzyme-Based Nucleic Acid Detection System for SARS-CoV-2. J Am Chem Soc. 2021 06 23; 143(24):8957-8961.
Yang K, Chaput JC. PMID: 34110141.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
-
Functional Comparison of Laboratory-Evolved XNA Polymerases for Synthetic Biology. ACS Synth Biol. 2021 06 18; 10(6):1429-1437.
Medina E, Yik EJ, Herdewijn P, Chaput JC. PMID: 34029459.
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PubMed Mentions:
5 Fields:
Translation:
Cells
-
Following replicative DNA synthesis by time-resolved X-ray crystallography. Nat Commun. 2021 05 11; 12(1):2641.
Chim N, Meza RA, Trinh AM, Yang K, Chaput JC. PMID: 33976175; PMCID: PMC8113479.
View in:
PubMed Mentions:
3 Fields:
Translation:
Cells
-
A biologically stable DNAzyme that efficiently silences gene expression in cells. Nat Chem. 2021 04; 13(4):319-326.
Wang Y, Nguyen K, Spitale RC, Chaput JC. PMID: 33767363.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
-
Allele-Specific RNA Knockdown with a Biologically Stable and Catalytically Efficient XNAzyme. J Am Chem Soc. 2021 03 31; 143(12):4519-4523.
Nguyen K, Wang Y, England WE, Chaput JC, Spitale RC. PMID: 33750115.
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PubMed Mentions:
8 Fields:
-
Redesigning the Genetic Polymers of Life. Acc Chem Res. 2021 02 16; 54(4):1056-1065.
Chaput JC. PMID: 33533593.
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PubMed Mentions:
7 Fields:
Translation:
Cells
-
Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization. Nucleic Acids Res. 2021 01 25; 49(2):646-656.
Zhang W, Kim SC, Tam CP, Lelyveld VS, Bala S, Chaput JC, Szostak JW. PMID: 33347562; PMCID: PMC7826252.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
-
Reading and Writing Digital Information in TNA. ACS Synth Biol. 2020 11 20; 9(11):2936-2942.
Yang K, McCloskey CM, Chaput JC. PMID: 32966745.
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PubMed Mentions:
5 Fields:
Translation:
Humans
-
In Vitro Selection of an ATP-Binding TNA Aptamer. Molecules. 2020 Sep 13; 25(18).
Zhang L, Chaput JC. PMID: 32933142; PMCID: PMC7570665.
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PubMed Mentions:
4 Fields:
Translation:
Cells
-
Engineering polymerases for applications in synthetic biology. Q Rev Biophys. 2020 07 27; 53:e8.
Nikoomanzar A, Chim N, Yik EJ, Chaput JC. PMID: 32715992.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
-
Synthesis and polymerase recognition of a pyrrolocytidine TNA triphosphate. Biopolymers. 2021 Jan; 112(1):e23388.
Mei H, Wang Y, Yik EJ, Chaput JC. PMID: 32615644.
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PubMed Mentions:
3 Fields:
Translation:
Cells
-
Programmed Allelic Mutagenesis of a DNA Polymerase with Single Amino Acid Resolution. ACS Synth Biol. 2020 07 17; 9(7):1873-1881.
Nikoomanzar A, Vallejo D, Yik EJ, Chaput JC. PMID: 32531152.
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PubMed Mentions:
4 Fields:
Translation:
Cells
-
Directed evolution of custom polymerases using droplet microfluidics. Methods Enzymol. 2020; 644:227-253.
Vallejo D, Nikoomanzar A, Chaput JC. PMID: 32943147.
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PubMed Mentions:
3 Fields:
Translation:
Cells
-
Generating Biologically Stable TNA Aptamers that Function with High Affinity and Thermal Stability. J Am Chem Soc. 2020 04 29; 142(17):7721-7724.
Dunn MR, McCloskey CM, Buckley P, Rhea K, Chaput JC. PMID: 32298104.
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PubMed Mentions:
20 Fields:
Translation:
Humans
-
Orthogonal Genetic Systems. Chembiochem. 2020 05 15; 21(10):1408-1411.
Chaput JC, Herdewijn P, Hollenstein M. PMID: 31889390.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
-
Evaluating the Catalytic Potential of a General RNA-Cleaving FANA Enzyme. Chembiochem. 2020 04 01; 21(7):1001-1006.
Wang Y, Vorperian A, Shehabat M, Chaput JC. PMID: 31680396.
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PubMed Mentions:
2 Fields:
Translation:
Cells
-
P(V) Reagents for the Scalable Synthesis of Natural and Modified Nucleoside Triphosphates. J Am Chem Soc. 2019 08 28; 141(34):13286-13289.
Liao JY, Bala S, Ngor AK, Yik EJ, Chaput JC. PMID: 31298849.
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PubMed Mentions:
9 Fields:
-
Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase. Nucleic Acids Res. 2019 07 26; 47(13):6973-6983.
Jackson LN, Chim N, Shi C, Chaput JC. PMID: 31170294; PMCID: PMC6649750.
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PubMed Mentions:
8 Fields:
Translation:
Cells
-
What Is XNA? Angew Chem Int Ed Engl. 2019 08 19; 58(34):11570-11572.
Chaput JC, Herdewijn P. PMID: 31210402.
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PubMed Mentions:
16 Fields:
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A Novel Small RNA-Cleaving Deoxyribozyme with a Short Binding Arm. Sci Rep. 2019 06 03; 9(1):8224.
Wang Y, Yang J, Yuan X, Cao J, Xu J, Chaput JC, Li Z, Yu H. PMID: 31160698; PMCID: PMC6546695.
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PubMed Mentions:
2 Fields:
Translation:
Cells
-
Fluorescence-Activated Droplet Sorting for Single-Cell Directed Evolution. ACS Synth Biol. 2019 06 21; 8(6):1430-1440.
Vallejo D, Nikoomanzar A, Paegel BM, Chaput JC. PMID: 31120731; PMCID: PMC6942126.
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PubMed Mentions:
22 Fields:
Translation:
Cells
-
Elucidating the Determinants of Polymerase Specificity by Microfluidic-Based Deep Mutational Scanning. ACS Synth Biol. 2019 06 21; 8(6):1421-1429.
Nikoomanzar A, Vallejo D, Chaput JC. PMID: 31081325.
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PubMed Mentions:
7 Fields:
Translation:
Cells
-
RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. ACS Synth Biol. 2019 05 17; 8(5):955-961.
Horning DP, Bala S, Chaput JC, Joyce GF. PMID: 31042360; PMCID: PMC8111818.
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PubMed Mentions:
7 Fields:
Translation:
Cells
-
Ligase-Mediated Threose Nucleic Acid Synthesis on DNA Templates. ACS Synth Biol. 2019 02 15; 8(2):282-286.
McCloskey CM, Liao JY, Bala S, Chaput JC. PMID: 30629885.
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PubMed Mentions:
4 Fields:
-
Synthesis of a Fluorescent Cytidine TNA Triphosphate Analogue. Methods Mol Biol. 2019; 1973:27-37.
Mei H, Chaput J. PMID: 31016694.
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PubMed Mentions: Fields:
-
Activation of Innate Immune Responses by a CpG Oligonucleotide Sequence Composed Entirely of Threose Nucleic Acid. Nucleic Acid Ther. 2019 02; 29(1):51-59.
Lange MJ, Burke DH, Chaput JC. PMID: 30526333; PMCID: PMC6939586.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Evolution of a General RNA-Cleaving FANA Enzyme. Nat Commun. 2018 11 29; 9(1):5067.
Wang Y, Ngor AK, Nikoomanzar A, Chaput JC. PMID: 30498223; PMCID: PMC6265334.
View in:
PubMed Mentions:
21 Fields:
Translation:
Cells
-
Exploring the Role of AUG Triplets in Human Cap-Independent Translation Enhancing Elements. Biochemistry. 2018 11 06; 57(44):6308-6318.
Juba AN, Chaput JC, Wellensiek BP. PMID: 30371061; PMCID: PMC6222554.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway. Elife. 2018 10 19; 7.
Chim N, Jackson LN, Trinh AM, Chaput JC. PMID: 30338759; PMCID: PMC6231770.
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PubMed Mentions:
8 Fields:
Translation:
Cells
-
Bacterial Genome Containing Chimeric DNA-RNA Sequences. J Am Chem Soc. 2018 09 12; 140(36):11464-11473.
Mehta AP, Wang Y, Reed SA, Supekova L, Javahishvili T, Chaput JC, Schultz PG. PMID: 30160955.
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PubMed Mentions:
4 Fields:
Translation:
Cells
-
Synthesis of 2'-Deoxy-α-l-threofuranosyl Nucleoside Triphosphates. J Org Chem. 2018 08 17; 83(16):8840-8850.
Bala S, Liao JY, Zhang L, Tran CN, Chim N, Chaput JC. PMID: 30011988.
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PubMed Mentions:
1 Fields:
Translation:
Cells
-
Visualizing primer extension without enzymes. Elife. 2018 05 31; 7.
Chaput JC. PMID: 29851382; PMCID: PMC5980227.
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PubMed Mentions: Fields:
-
Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues. J Am Chem Soc. 2018 05 02; 140(17):5706-5713.
Mei H, Liao JY, Jimenez RM, Wang Y, Bala S, McCloskey C, Switzer C, Chaput JC. PMID: 29667819.
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PubMed Mentions:
25 Fields:
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Made in translation. Nat Chem. 2018 Apr; 10(4):379-381.
Chaput JC. PMID: 29568049.
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PubMed Mentions: Fields:
Translation:
Cells
-
Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase. Chem Commun (Camb). 2018 Jan 31; 54(10):1237-1240.
Mei H, Chaput JC. PMID: 29340357.
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PubMed Mentions:
3 Fields:
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A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria. J Am Chem Soc. 2018 01 31; 140(4):1447-1454.
Feldman AW, Fischer EC, Ledbetter MP, Liao JY, Chaput JC, Romesberg FE. PMID: 29338214; PMCID: PMC5809120.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
Structural basis for TNA synthesis by an engineered TNA polymerase. Nat Commun. 2017 11 27; 8(1):1810.
Chim N, Shi C, Sau SP, Nikoomanzar A, Chaput JC. PMID: 29180809; PMCID: PMC5703726.
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PubMed Mentions:
16 Fields:
Translation:
Cells
-
Evaluating the Rate and Substrate Specificity of Laboratory Evolved XNA Polymerases. Anal Chem. 2017 12 05; 89(23):12622-12625.
Nikoomanzar A, Dunn MR, Chaput JC. PMID: 29148714.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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A Gram-Scale HPLC-Free Synthesis of TNA Triphosphates Using an Iterative Phosphorylation Strategy. Org Lett. 2017 08 18; 19(16):4379-4382.
Sau SP, Chaput JC. PMID: 28766949.
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PubMed Mentions:
4 Fields:
-
Engineered Polymerases with Altered Substrate Specificity: Expression and Purification. Curr Protoc Nucleic Acid Chem. 2017 06 19; 69:4.75.1-4.75.20.
Nikoomanzar A, Dunn MR, Chaput JC. PMID: 28628207.
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PubMed Mentions:
7 Fields:
Translation:
Cells
-
Synthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue. Nucleic Acids Res. 2017 Jun 02; 45(10):5629-5638.
Mei H, Shi C, Jimenez RM, Wang Y, Kardouh M, Chaput JC. PMID: 28472363; PMCID: PMC5449585.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Synthesis of α-l-Threofuranosyl Nucleoside 3'-Monophosphates, 3'-Phosphoro(2-Methyl)imidazolides, and 3'-Triphosphates. J Org Chem. 2017 06 02; 82(11):5910-5916.
Bala S, Liao JY, Mei H, Chaput JC. PMID: 28490177.
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PubMed Mentions:
4 Fields:
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A parallel stranded G-quadruplex composed of threose nucleic acid (TNA). Biopolymers. 2017 Mar; 107(3).
Liao JY, Anosova I, Bala S, Van Horn WD, Chaput JC. PMID: 27718227.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Reverse Transcription of Threose Nucleic Acid by a Naturally Occurring DNA Polymerase. Chembiochem. 2016 10 04; 17(19):1804-1808.
Dunn MR, Chaput JC. PMID: 27383648.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
-
Structural Insights into Conformation Differences between DNA/TNA and RNA/TNA Chimeric Duplexes. Chembiochem. 2016 09 15; 17(18):1705-8.
Anosova I, Kowal EA, Sisco NJ, Sau S, Liao JY, Bala S, Rozners E, Egli M, Chaput JC, Van Horn WD. PMID: 27347671; PMCID: PMC5242226.
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PubMed Mentions:
12 Fields:
Translation:
Cells
-
A one-pot synthesis of α-l-threofuranosyl nucleoside triphosphates (tNTPs). Bioorg Med Chem Lett. 2016 07 15; 26(14):3271-3273.
Sau SP, Chaput JC. PMID: 27246616.
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PubMed Mentions:
4 Fields:
Translation:
Cells
-
A general strategy for expanding polymerase function by droplet microfluidics. Nat Commun. 2016 Apr 05; 7:11235.
Larsen AC, Dunn MR, Hatch A, Sau SP, Youngbull C, Chaput JC. PMID: 27044725; PMCID: PMC4822039.
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PubMed Mentions:
45 Fields:
Translation:
Cells
-
Evaluating TNA stability under simulated physiological conditions. Bioorg Med Chem Lett. 2016 05 15; 26(10):2418-2421.
Culbertson MC, Temburnikar KW, Sau SP, Liao JY, Bala S, Chaput JC. PMID: 27080186.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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A Scalable Synthesis of α-L-Threose Nucleic Acid Monomers. J Org Chem. 2016 Mar 18; 81(6):2302-7.
Sau SP, Fahmi NE, Liao JY, Bala S, Chaput JC. PMID: 26895480.
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PubMed Mentions:
19 Fields:
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Improving Polymerase Activity with Unnatural Substrates by Sampling Mutations in Homologous Protein Architectures. ACS Chem Biol. 2016 05 20; 11(5):1210-9.
Dunn MR, Otto C, Fenton KE, Chaput JC. PMID: 26860781.
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PubMed Mentions:
19 Fields:
Translation:
Cells
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The structural diversity of artificial genetic polymers. Nucleic Acids Res. 2016 Feb 18; 44(3):1007-21.
Anosova I, Kowal EA, Dunn MR, Chaput JC, Van Horn WD, Egli M. PMID: 26673703; PMCID: PMC4756832.
View in:
PubMed Mentions:
51 Fields:
Translation:
Cells
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Comparative analysis of eukaryotic cell-free expression systems. Biotechniques. 2015 Sep; 59(3):149-51.
Hartsough EM, Shah P, Larsen AC, Chaput JC. PMID: 26345507.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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DNA polymerase-mediated synthesis of unbiased threose nucleic acid (TNA) polymers requires 7-deazaguanine to suppress G:G mispairing during TNA transcription. J Am Chem Soc. 2015 Apr 01; 137(12):4014-7.
Dunn MR, Larsen AC, Zahurancik WJ, Fahmi NE, Meyers M, Suo Z, Chaput JC. PMID: 25785966.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Automated solid-phase synthesis of high capacity oligo-dT cellulose for affinity purification of poly-A tagged biomolecules. Bioorg Med Chem Lett. 2014 Dec 15; 24(24):5692-5694.
Sau SP, Larsen AC, Chaput JC. PMID: 25467163.
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PubMed Mentions:
3 Fields:
Translation:
Humans
-
Replicating an expanded genetic alphabet in cells. Chembiochem. 2014 Sep 05; 15(13):1869-71.
Chaput JC. PMID: 25044483.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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General approach for characterizing in vitro selected peptides with protein binding affinity. Anal Chem. 2014 Aug 05; 86(15):7219-23.
Larsen AC, Gillig A, Shah P, Sau SP, Fenton KE, Chaput JC. PMID: 24970615; PMCID: PMC4215864.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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An In Vitro Selection Protocol for Threose Nucleic Acid (TNA) Using DNA Display. Curr Protoc Nucleic Acid Chem. 2014 Jun 24; 57:9.8.1-19.
Dunn MR, Chaput JC. PMID: 24961723.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Development of a full-length human protein production pipeline. Protein Sci. 2014 Aug; 23(8):1123-35.
Saul J, Petritis B, Sau S, Rauf F, Gaskin M, Ober-Reynolds B, Mineyev I, Magee M, Chaput J, Qiu J, LaBaer J. PMID: 24806540; PMCID: PMC4116660.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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A leader sequence capable of enhancing RNA expression and protein synthesis in mammalian cells. Protein Sci. 2013 Oct; 22(10):1392-8.
Wellensiek BP, Larsen AC, Flores J, Jacobs BL, Chaput JC. PMID: 23908110; PMCID: PMC3795497.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Genome-wide profiling of human cap-independent translation-enhancing elements. Nat Methods. 2013 Aug; 10(8):747-50.
Wellensiek BP, Larsen AC, Stephens B, Kukurba K, Waern K, Briones N, Liu L, Snyder M, Jacobs BL, Kumar S, Chaput JC. PMID: 23770754; PMCID: PMC3731418.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Synthesis of threose nucleic acid (TNA) triphosphates and oligonucleotides by polymerase-mediated primer extension. Curr Protoc Nucleic Acid Chem. 2013 Mar; Chapter 4:Unit 4.54.
Zhang S, Yu H, Chaput JC. PMID: 23512696.
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PubMed Mentions:
2 Fields:
-
An efficient and faithful in vitro replication system for threose nucleic acid. J Am Chem Soc. 2013 Mar 06; 135(9):3583-91.
Yu H, Zhang S, Dunn MR, Chaput JC. PMID: 23432469.
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PubMed Mentions:
18 Fields:
Translation:
Cells
-
Synthesis and enzymatic incorporation of α-L-threofuranosyl adenine triphosphate (tATP). Bioorg Med Chem Lett. 2013 Mar 01; 23(5):1447-9.
Zhang S, Chaput JC. PMID: 23352269.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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ATP sequestration by a synthetic ATP-binding protein leads to novel phenotypic changes in Escherichia coli. ACS Chem Biol. 2013 Feb 15; 8(2):451-63.
Korch SB, Stomel JM, León MA, Hamada MA, Stevenson CR, Simpson BW, Gujulla SK, Chaput JC. PMID: 23181457.
View in:
PubMed Mentions:
2 Fields:
Translation:
Cells
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The emerging world of synthetic genetics. Chem Biol. 2012 Nov 21; 19(11):1360-71.
Chaput JC, Yu H, Zhang S. PMID: 23177191.
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PubMed Mentions:
26 Fields:
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Synthesis of threose nucleic acid (TNA) phosphoramidite monomers and oligonucleotide polymers. Curr Protoc Nucleic Acid Chem. 2012 Sep; Chapter 4:Unit4.51.
Zhang S, Chaput JC. PMID: 22956457.
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PubMed Mentions:
3 Fields:
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Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4 T) in the presence of Cs+ ions. Angew Chem Int Ed Engl. 2012 Aug 06; 51(32):7952-5.
Kang M, Heuberger B, Chaput JC, Switzer C, Feigon J. PMID: 22767484.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Synthetic genetic polymers capable of heredity and evolution. Science. 2012 Apr 20; 336(6079):341-4.
Pinheiro VB, Taylor AI, Cozens C, Abramov M, Renders M, Zhang S, Chaput JC, Wengel J, Peak-Chew SY, McLaughlin SH, Herdewijn P, Holliger P. PMID: 22517858; PMCID: PMC3362463.
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PubMed Mentions:
189 Fields:
Translation:
Cells
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Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor. Nat Chem. 2012 Jan 10; 4(3):183-7.
Yu H, Zhang S, Chaput JC. PMID: 22354431.
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PubMed Mentions:
70 Fields:
Translation:
HumansAnimalsCells
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Aptamers can discriminate alkaline proteins with high specificity. Chembiochem. 2011 Nov 25; 12(17):2659-66.
Yu H, Jiang B, Chaput JC. PMID: 22021204; PMCID: PMC3517100.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Generating DNA synbodies from previously discovered peptides. Chembiochem. 2011 Aug 16; 12(12):1813-7.
Liu R, Jiang B, Yu H, Chaput JC. PMID: 21692159; PMCID: PMC3390916.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Three-dimensional structures reveal multiple ADP/ATP binding modes for a synthetic class of artificial proteins. Biochemistry. 2010 Oct 12; 49(40):8689-99.
Simmons CR, Magee CL, Smith DA, Lauman L, Chaput JC, Allen JP. PMID: 20822107.
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PubMed Mentions: Fields:
Translation:
Cells
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The evolvability of lead peptides from small library screens. Chem Commun (Camb). 2010 Nov 07; 46(41):7778-80.
Zhang J, Williams BA, Nilsson MT, Chaput JC. PMID: 20830334.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Synthesis of peptide-oligonucleotide conjugates using a heterobifunctional crosslinker. Curr Protoc Nucleic Acid Chem. 2010 Sep; Chapter 4:Unit4.41.
Williams BA, Chaput JC. PMID: 20827717; PMCID: PMC2947322.
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PubMed Mentions:
7 Fields:
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Synthesis of glycerol nucleic acid (GNA) phosphoramidite monomers and oligonucleotide polymers. Curr Protoc Nucleic Acid Chem. 2010 Sep; Chapter 4:Unit4.40.
Zhang S, Chaput JC. PMID: 20827716.
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PubMed Mentions:
1 Fields:
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The resurgence of acyclic nucleic acids. Chem Biodivers. 2010 Feb; 7(2):245-58.
Zhang S, Switzer C, Chaput JC. PMID: 20151377.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
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Random mutagenesis by error-prone PCR. Methods Mol Biol. 2010; 634:103-9.
McCullum EO, Williams BA, Zhang J, Chaput JC. PMID: 20676978.
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PubMed Mentions:
57 Fields:
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Creating protein affinity reagents by combining peptide ligands on synthetic DNA scaffolds. J Am Chem Soc. 2009 Dec 02; 131(47):17233-41.
Williams BA, Diehnelt CW, Belcher P, Greving M, Woodbury NW, Johnston SA, Chaput JC. PMID: 19894711; PMCID: PMC2796340.
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PubMed Mentions:
23 Fields:
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A man-made ATP-binding protein evolved independent of nature causes abnormal growth in bacterial cells. PLoS One. 2009 Oct 08; 4(10):e7385.
Stomel JM, Wilson JW, León MA, Stafford P, Chaput JC. PMID: 19812699; PMCID: PMC2754611.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Recognition imaging of acetylated chromatin using a DNA aptamer. Biophys J. 2009 Sep 16; 97(6):1804-7.
Lin L, Fu Q, Williams BA, Azzaz AM, Shogren-Knaak MA, Chaput JC, Lindsay S. PMID: 19751687; PMCID: PMC2749789.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy. J Phys Chem A. 2009 Sep 03; 113(35):9585-7.
Lin S, Horning DP, Szostak JW, Chaput JC. PMID: 19673467; PMCID: PMC2733762.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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A synthetic protein selected for ligand binding affinity mediates ATP hydrolysis. ACS Chem Biol. 2009 Aug 21; 4(8):649-58.
Simmons CR, Stomel JM, McConnell MD, Smith DA, Watkins JL, Allen JP, Chaput JC. PMID: 19522480.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Evolution of a histone H4-K16 acetyl-specific DNA aptamer. J Am Chem Soc. 2009 May 13; 131(18):6330-1.
Williams BA, Lin L, Lindsay SM, Chaput JC. PMID: 19385619; PMCID: PMC2715991.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Transcription of an RNA aptamer by a DNA polymerase. Chem Commun (Camb). 2009 May 28; (20):2938-40.
McCullum EO, Chaput JC. PMID: 19436916.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Template-directed nucleation and growth of inorganic nanoparticles on DNA scaffolds. Angew Chem Int Ed Engl. 2009; 48(45):8494-6.
Stearns LA, Chhabra R, Sharma J, Liu Y, Petuskey WT, Yan H, Chaput JC. PMID: 19795428.
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PubMed Mentions:
16 Fields:
Translation:
Cells
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Creating protein biocatalysts as tools for future industrial applications. Expert Opin Biol Ther. 2008 Aug; 8(8):1087-98.
Chaput JC, Woodbury NW, Stearns LA, Williams BA. PMID: 18613761.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Searching combinatorial libraries for native proteins with novel folds. Chembiochem. 2008 Jun 16; 9(9):1361-3.
Watkins JL, Chaput JC. PMID: 18464233.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Synthesis of two mirror image 4-helix junctions derived from glycerol nucleic acid. J Am Chem Soc. 2008 May 07; 130(18):5846-7.
Zhang RS, McCullum EO, Chaput JC. PMID: 18407636.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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In vitro selection of histone H4 aptamers for recognition imaging microscopy. J Am Chem Soc. 2007 Nov 28; 129(47):14568-9.
Lin L, Hom D, Lindsay SM, Chaput JC. PMID: 17985909; PMCID: PMC2533041.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Experimental evidence that GNA and TNA were not sequential polymers in the prebiotic evolution of RNA. J Mol Evol. 2007 Sep; 65(3):289-95.
Yang YW, Zhang S, McCullum EO, Chaput JC. PMID: 17828568.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol. 2007 Aug 10; 371(2):501-13.
Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. PMID: 17583732.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS One. 2007 May 23; 2(5):e467.
Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC. PMID: 17520026; PMCID: PMC1867856.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Self-assembled peptide nanoarrays: an approach to studying protein-protein interactions. Angew Chem Int Ed Engl. 2007; 46(17):3051-4.
Williams BA, Lund K, Liu Y, Yan H, Chaput JC. PMID: 17361972.
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PubMed Mentions:
29 Fields:
Translation:
Cells
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Kinetic analysis of an efficient DNA-dependent TNA polymerase. J Am Chem Soc. 2005 May 25; 127(20):7427-34.
Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC. PMID: 15898792; PMCID: PMC5042361.
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PubMed Mentions:
37 Fields:
Translation:
Cells
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Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. Chem Biol. 2004 Jun; 11(6):865-74.
Chaput JC, Szostak JW. PMID: 15217619.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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TNA synthesis by DNA polymerases. J Am Chem Soc. 2003 Aug 06; 125(31):9274-5.
Chaput JC, Szostak JW. PMID: 12889939.
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PubMed Mentions:
28 Fields:
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DNA polymerase-mediated DNA synthesis on a TNA template. J Am Chem Soc. 2003 Jan 29; 125(4):856-7.
Chaput JC, Ichida JK, Szostak JW. PMID: 12537469.
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PubMed Mentions:
29 Fields:
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5-propynyluracil.diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA. Chem Commun (Camb). 2002 Aug 07; (15):1568-9.
Chaput JC, Sinha S, Switzer C. PMID: 12170785.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Probing structure and function with alternative nucleic acids bearing 2',5'-linked, zwitterionic, and isocytosine-isoguanine components. Methods. 2001 Feb; 23(2):141-8.
Switzer C, Chaput JC. PMID: 11181033.
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PubMed Mentions: Fields:
Translation:
Cells
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Nonenzymatic oligomerization on templates containing phosphodiester-linked acyclic glycerol nucleic acid analogues. J Mol Evol. 2000 Nov; 51(5):464-70.
Chaput JC, Switzer C. PMID: 11080369.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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RecA protein promotes strand exchange with DNA substrates containing isoguanine and 5-methyl isocytosine. Biochemistry. 2000 Aug 22; 39(33):10177-88.
Rice KP, Chaput JC, Cox MM, Switzer C. PMID: 10956007.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Pretreatment expression of the perforin gene by circulating CD8(+) T lymphocytes predicts biochemical response to interferon-alpha in patients with chronic hepatitis C. Eur Cytokine Netw. 2000 Jun; 11(2):177-84.
Balian A, Naveau S, Zou W, Durand-Gasselin I, Bouchet L, Foussat A, Galanaud P, Chaput JC, Emilie D. PMID: 10903796.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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A DNA pentaplex incorporating nucleobase quintets. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10614-9.
Chaput JC, Switzer C. PMID: 10485874; PMCID: PMC17931.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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Beyond guanine quartets: cation-induced formation of homogenous and chimeric DNA tetraplexes incorporating iso-guanine and guanine. Chem Biol. 1997 Dec; 4(12):899-908.
Roberts C, Chaput JC, Switzer C. PMID: 9427655.
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PubMed Mentions:
7 Fields: