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John Charles Chaput

Title(s)Professor, Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-8149, 8957
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    Collapse Research 
    Collapse Research Activities and Funding
    A Pipeline for Production of Bivalent Synthetic Antibodies to the Human Proteome
    NIH/NIDDK U54DK093449Sep 25, 2011 - Jul 31, 2014
    Role: Principal Investigator
    A High-throughput Route to Synthetic Antibodies for Array-based Cancer Detection
    NIH/NCI R21CA126622Sep 29, 2008 - Aug 31, 2011
    Role: Principal Investigator
    Discovering a Hidden Proteome in the Human Genome
    NIH/NIGMS R01GM085530Aug 1, 2008 - Jul 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reading and Writing Digital Information in TNA. ACS Synth Biol. 2020 Sep 23. Yang K, McCloskey CM, Chaput JC. PMID: 32966745.
      View in: PubMed   Mentions:    Fields:    
    2. In Vitro Selection of an ATP-Binding TNA Aptamer. Molecules. 2020 Sep 13; 25(18). Zhang L, Chaput JC. PMID: 32933142.
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    3. Engineering polymerases for applications in synthetic biology. Q Rev Biophys. 2020 Jul 27; 53:e8. Nikoomanzar A, Chim N, Yik EJ, Chaput JC. PMID: 32715992.
      View in: PubMed   Mentions: 1     Fields:    
    4. Synthesis and polymerase recognition of a pyrrolocytidine TNA triphosphate. Biopolymers. 2020 Jul 02; e23388. Mei H, Wang Y, Yik EJ, Chaput JC. PMID: 32615644.
      View in: PubMed   Mentions:    Fields:    
    5. Programmed Allelic Mutagenesis of a DNA Polymerase with Single Amino Acid Resolution. ACS Synth Biol. 2020 07 17; 9(7):1873-1881. Nikoomanzar A, Vallejo D, Yik EJ, Chaput JC. PMID: 32531152.
      View in: PubMed   Mentions:    Fields:    
    6. Directed evolution of custom polymerases using droplet microfluidics. Methods Enzymol. 2020; 644:227-253. Vallejo D, Nikoomanzar A, Chaput JC. PMID: 32943147.
      View in: PubMed   Mentions:    Fields:    
    7. Generating Biologically Stable TNA Aptamers that Function with High Affinity and Thermal Stability. J Am Chem Soc. 2020 Apr 29; 142(17):7721-7724. Dunn MR, McCloskey CM, Buckley P, Rhea K, Chaput JC. PMID: 32298104.
      View in: PubMed   Mentions: 3     Fields:    
    8. Orthogonal Genetic Systems. Chembiochem. 2020 May 15; 21(10):1408-1411. Chaput JC, Herdewijn P, Hollenstein M. PMID: 31889390.
      View in: PubMed   Mentions:    Fields:    
    9. Evaluating the Catalytic Potential of a General RNA-Cleaving FANA Enzyme. Chembiochem. 2020 Apr 01; 21(7):1001-1006. Wang Y, Vorperian A, Shehabat M, Chaput JC. PMID: 31680396.
      View in: PubMed   Mentions: 1     Fields:    
    10. P(V) Reagents for the Scalable Synthesis of Natural and Modified Nucleoside Triphosphates. J Am Chem Soc. 2019 08 28; 141(34):13286-13289. Liao JY, Bala S, Ngor AK, Yik EJ, Chaput JC. PMID: 31298849.
      View in: PubMed   Mentions: 1     Fields:    
    11. Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase. Nucleic Acids Res. 2019 07 26; 47(13):6973-6983. Jackson LN, Chim N, Shi C, Chaput JC. PMID: 31170294.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    12. What Is XNA? Angew Chem Int Ed Engl. 2019 08 19; 58(34):11570-11572. Chaput JC, Herdewijn P. PMID: 31210402.
      View in: PubMed   Mentions: 1     Fields:    
    13. A Novel Small RNA-Cleaving Deoxyribozyme with a Short Binding Arm. Sci Rep. 2019 06 03; 9(1):8224. Wang Y, Yang J, Yuan X, Cao J, Xu J, Chaput JC, Li Z, Yu H. PMID: 31160698.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    14. Fluorescence-Activated Droplet Sorting for Single-Cell Directed Evolution. ACS Synth Biol. 2019 06 21; 8(6):1430-1440. Vallejo D, Nikoomanzar A, Paegel BM, Chaput JC. PMID: 31120731.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    15. Elucidating the Determinants of Polymerase Specificity by Microfluidic-Based Deep Mutational Scanning. ACS Synth Biol. 2019 06 21; 8(6):1421-1429. Nikoomanzar A, Vallejo D, Chaput JC. PMID: 31081325.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    16. RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. ACS Synth Biol. 2019 05 17; 8(5):955-961. Horning DP, Bala S, Chaput JC, Joyce GF. PMID: 31042360.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    17. Ligase-Mediated Threose Nucleic Acid Synthesis on DNA Templates. ACS Synth Biol. 2019 02 15; 8(2):282-286. McCloskey CM, Liao JY, Bala S, Chaput JC. PMID: 30629885.
      View in: PubMed   Mentions: 2     Fields:    
    18. Synthesis of a Fluorescent Cytidine TNA Triphosphate Analogue. Methods Mol Biol. 2019; 1973:27-37. Mei H, Chaput J. PMID: 31016694.
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    19. Activation of Innate Immune Responses by a CpG Oligonucleotide Sequence Composed Entirely of Threose Nucleic Acid. Nucleic Acid Ther. 2019 02; 29(1):51-59. Lange MJ, Burke DH, Chaput JC. PMID: 30526333.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Evolution of a General RNA-Cleaving FANA Enzyme. Nat Commun. 2018 11 29; 9(1):5067. Wang Y, Ngor AK, Nikoomanzar A, Chaput JC. PMID: 30498223.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    21. Exploring the Role of AUG Triplets in Human Cap-Independent Translation Enhancing Elements. Biochemistry. 2018 11 06; 57(44):6308-6318. Juba AN, Chaput JC, Wellensiek BP. PMID: 30371061.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway. Elife. 2018 10 19; 7. Chim N, Jackson LN, Trinh AM, Chaput JC. PMID: 30338759.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    23. Bacterial Genome Containing Chimeric DNA-RNA Sequences. J Am Chem Soc. 2018 09 12; 140(36):11464-11473. Mehta AP, Wang Y, Reed SA, Supekova L, Javahishvili T, Chaput JC, Schultz PG. PMID: 30160955.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    24. Synthesis of 2'-Deoxy-a-l-threofuranosyl Nucleoside Triphosphates. J Org Chem. 2018 08 17; 83(16):8840-8850. Bala S, Liao JY, Zhang L, Tran CN, Chim N, Chaput JC. PMID: 30011988.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    25. Visualizing primer extension without enzymes. Elife. 2018 05 31; 7. Chaput JC. PMID: 29851382.
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    26. Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues. J Am Chem Soc. 2018 05 02; 140(17):5706-5713. Mei H, Liao JY, Jimenez RM, Wang Y, Bala S, McCloskey C, Switzer C, Chaput JC. PMID: 29667819.
      View in: PubMed   Mentions: 9     Fields:    
    27. Made in translation. Nat Chem. 2018 Apr; 10(4):379-381. Chaput JC. PMID: 29568049.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    28. Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase. Chem Commun (Camb). 2018 Jan 31; 54(10):1237-1240. Mei H, Chaput JC. PMID: 29340357.
      View in: PubMed   Mentions: 2     Fields:    
    29. A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria. J Am Chem Soc. 2018 01 31; 140(4):1447-1454. Feldman AW, Fischer EC, Ledbetter MP, Liao JY, Chaput JC, Romesberg FE. PMID: 29338214.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Structural basis for TNA synthesis by an engineered TNA polymerase. Nat Commun. 2017 11 27; 8(1):1810. Chim N, Shi C, Sau SP, Nikoomanzar A, Chaput JC. PMID: 29180809.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    31. Evaluating the Rate and Substrate Specificity of Laboratory Evolved XNA Polymerases. Anal Chem. 2017 12 05; 89(23):12622-12625. Nikoomanzar A, Dunn MR, Chaput JC. PMID: 29148714.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    32. A Gram-Scale HPLC-Free Synthesis of TNA Triphosphates Using an Iterative Phosphorylation Strategy. Org Lett. 2017 08 18; 19(16):4379-4382. Sau SP, Chaput JC. PMID: 28766949.
      View in: PubMed   Mentions: 1     Fields:    
    33. Engineered Polymerases with Altered Substrate Specificity: Expression and Purification. Curr Protoc Nucleic Acid Chem. 2017 06 19; 69:4.75.1-4.75.20. Nikoomanzar A, Dunn MR, Chaput JC. PMID: 28628207.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    34. Synthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue. Nucleic Acids Res. 2017 Jun 02; 45(10):5629-5638. Mei H, Shi C, Jimenez RM, Wang Y, Kardouh M, Chaput JC. PMID: 28472363.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    35. Synthesis of a-l-Threofuranosyl Nucleoside 3'-Monophosphates, 3'-Phosphoro(2-Methyl)imidazolides, and 3'-Triphosphates. J Org Chem. 2017 06 02; 82(11):5910-5916. Bala S, Liao JY, Mei H, Chaput JC. PMID: 28490177.
      View in: PubMed   Mentions: 1     Fields:    
    36. A parallel stranded G-quadruplex composed of threose nucleic acid (TNA). Biopolymers. 2017 Mar; 107(3). Liao JY, Anosova I, Bala S, Van Horn WD, Chaput JC. PMID: 27718227.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    37. Reverse Transcription of Threose Nucleic Acid by a Naturally Occurring DNA Polymerase. Chembiochem. 2016 10 04; 17(19):1804-1808. Dunn MR, Chaput JC. PMID: 27383648.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    38. Structural Insights into Conformation Differences between DNA/TNA and RNA/TNA Chimeric Duplexes. Chembiochem. 2016 09 15; 17(18):1705-8. Anosova I, Kowal EA, Sisco NJ, Sau S, Liao JY, Bala S, Rozners E, Egli M, Chaput JC, Van Horn WD. PMID: 27347671.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    39. A one-pot synthesis of a-l-threofuranosyl nucleoside triphosphates (tNTPs). Bioorg Med Chem Lett. 2016 07 15; 26(14):3271-3273. Sau SP, Chaput JC. PMID: 27246616.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    40. A general strategy for expanding polymerase function by droplet microfluidics. Nat Commun. 2016 Apr 05; 7:11235. Larsen AC, Dunn MR, Hatch A, Sau SP, Youngbull C, Chaput JC. PMID: 27044725.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    41. Evaluating TNA stability under simulated physiological conditions. Bioorg Med Chem Lett. 2016 05 15; 26(10):2418-2421. Culbertson MC, Temburnikar KW, Sau SP, Liao JY, Bala S, Chaput JC. PMID: 27080186.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    42. A Scalable Synthesis of a-L-Threose Nucleic Acid Monomers. J Org Chem. 2016 Mar 18; 81(6):2302-7. Sau SP, Fahmi NE, Liao JY, Bala S, Chaput JC. PMID: 26895480.
      View in: PubMed   Mentions: 9     Fields:    
    43. Improving Polymerase Activity with Unnatural Substrates by Sampling Mutations in Homologous Protein Architectures. ACS Chem Biol. 2016 05 20; 11(5):1210-9. Dunn MR, Otto C, Fenton KE, Chaput JC. PMID: 26860781.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    44. The structural diversity of artificial genetic polymers. Nucleic Acids Res. 2016 Feb 18; 44(3):1007-21. Anosova I, Kowal EA, Dunn MR, Chaput JC, Van Horn WD, Egli M. PMID: 26673703.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    45. Comparative analysis of eukaryotic cell-free expression systems. Biotechniques. 2015 Sep; 59(3):149-51. Hartsough EM, Shah P, Larsen AC, Chaput JC. PMID: 26345507.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    46. DNA polymerase-mediated synthesis of unbiased threose nucleic acid (TNA) polymers requires 7-deazaguanine to suppress G:G mispairing during TNA transcription. J Am Chem Soc. 2015 Apr 01; 137(12):4014-7. Dunn MR, Larsen AC, Zahurancik WJ, Fahmi NE, Meyers M, Suo Z, Chaput JC. PMID: 25785966.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    47. Automated solid-phase synthesis of high capacity oligo-dT cellulose for affinity purification of poly-A tagged biomolecules. Bioorg Med Chem Lett. 2014 Dec 15; 24(24):5692-5694. Sau SP, Larsen AC, Chaput JC. PMID: 25467163.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    48. Replicating an expanded genetic alphabet in cells. Chembiochem. 2014 Sep 05; 15(13):1869-71. Chaput JC. PMID: 25044483.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    49. General approach for characterizing in vitro selected peptides with protein binding affinity. Anal Chem. 2014 Aug 05; 86(15):7219-23. Larsen AC, Gillig A, Shah P, Sau SP, Fenton KE, Chaput JC. PMID: 24970615.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    50. An In Vitro Selection Protocol for Threose Nucleic Acid (TNA) Using DNA Display. Curr Protoc Nucleic Acid Chem. 2014 Jun 24; 57:9.8.1-19. Dunn MR, Chaput JC. PMID: 24961723.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    51. Development of a full-length human protein production pipeline. Protein Sci. 2014 Aug; 23(8):1123-35. Saul J, Petritis B, Sau S, Rauf F, Gaskin M, Ober-Reynolds B, Mineyev I, Magee M, Chaput J, Qiu J, LaBaer J. PMID: 24806540.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    52. A leader sequence capable of enhancing RNA expression and protein synthesis in mammalian cells. Protein Sci. 2013 Oct; 22(10):1392-8. Wellensiek BP, Larsen AC, Flores J, Jacobs BL, Chaput JC. PMID: 23908110.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    53. Genome-wide profiling of human cap-independent translation-enhancing elements. Nat Methods. 2013 Aug; 10(8):747-50. Wellensiek BP, Larsen AC, Stephens B, Kukurba K, Waern K, Briones N, Liu L, Snyder M, Jacobs BL, Kumar S, Chaput JC. PMID: 23770754.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    54. Synthesis of threose nucleic acid (TNA) triphosphates and oligonucleotides by polymerase-mediated primer extension. Curr Protoc Nucleic Acid Chem. 2013 Mar; Chapter 4:Unit 4.54. Zhang S, Yu H, Chaput JC. PMID: 23512696.
      View in: PubMed   Mentions: 2     Fields:    
    55. An efficient and faithful in vitro replication system for threose nucleic acid. J Am Chem Soc. 2013 Mar 06; 135(9):3583-91. Yu H, Zhang S, Dunn MR, Chaput JC. PMID: 23432469.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    56. Synthesis and enzymatic incorporation of a-L-threofuranosyl adenine triphosphate (tATP). Bioorg Med Chem Lett. 2013 Mar 01; 23(5):1447-9. Zhang S, Chaput JC. PMID: 23352269.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    57. ATP sequestration by a synthetic ATP-binding protein leads to novel phenotypic changes in Escherichia coli. ACS Chem Biol. 2013 Feb 15; 8(2):451-63. Korch SB, Stomel JM, León MA, Hamada MA, Stevenson CR, Simpson BW, Gujulla SK, Chaput JC. PMID: 23181457.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    58. The emerging world of synthetic genetics. Chem Biol. 2012 Nov 21; 19(11):1360-71. Chaput JC, Yu H, Zhang S. PMID: 23177191.
      View in: PubMed   Mentions: 18     Fields:    
    59. Synthesis of threose nucleic acid (TNA) phosphoramidite monomers and oligonucleotide polymers. Curr Protoc Nucleic Acid Chem. 2012 Sep; Chapter 4:Unit4.51. Zhang S, Chaput JC. PMID: 22956457.
      View in: PubMed   Mentions: 2     Fields:    
    60. Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4 T) in the presence of Cs+ ions. Angew Chem Int Ed Engl. 2012 Aug 06; 51(32):7952-5. Kang M, Heuberger B, Chaput JC, Switzer C, Feigon J. PMID: 22767484.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    61. Synthetic genetic polymers capable of heredity and evolution. Science. 2012 Apr 20; 336(6079):341-4. Pinheiro VB, Taylor AI, Cozens C, Abramov M, Renders M, Zhang S, Chaput JC, Wengel J, Peak-Chew SY, McLaughlin SH, Herdewijn P, Holliger P. PMID: 22517858.
      View in: PubMed   Mentions: 119     Fields:    Translation:Cells
    62. Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor. Nat Chem. 2012 Jan 10; 4(3):183-7. Yu H, Zhang S, Chaput JC. PMID: 22354431.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    63. Aptamers can discriminate alkaline proteins with high specificity. Chembiochem. 2011 Nov 25; 12(17):2659-66. Yu H, Jiang B, Chaput JC. PMID: 22021204.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    64. Generating DNA synbodies from previously discovered peptides. Chembiochem. 2011 Aug 16; 12(12):1813-7. Liu R, Jiang B, Yu H, Chaput JC. PMID: 21692159.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    65. Three-dimensional structures reveal multiple ADP/ATP binding modes for a synthetic class of artificial proteins. Biochemistry. 2010 Oct 12; 49(40):8689-99. Simmons CR, Magee CL, Smith DA, Lauman L, Chaput JC, Allen JP. PMID: 20822107.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    66. The evolvability of lead peptides from small library screens. Chem Commun (Camb). 2010 Nov 07; 46(41):7778-80. Zhang J, Williams BA, Nilsson MT, Chaput JC. PMID: 20830334.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    67. Synthesis of peptide-oligonucleotide conjugates using a heterobifunctional crosslinker. Curr Protoc Nucleic Acid Chem. 2010 Sep; Chapter 4:Unit4.41. Williams BA, Chaput JC. PMID: 20827717.
      View in: PubMed   Mentions: 3     Fields:    
    68. Synthesis of glycerol nucleic acid (GNA) phosphoramidite monomers and oligonucleotide polymers. Curr Protoc Nucleic Acid Chem. 2010 Sep; Chapter 4:Unit4.40. Zhang S, Chaput JC. PMID: 20827716.
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    69. The resurgence of acyclic nucleic acids. Chem Biodivers. 2010 Feb; 7(2):245-58. Zhang S, Switzer C, Chaput JC. PMID: 20151377.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    70. Random mutagenesis by error-prone PCR. Methods Mol Biol. 2010; 634:103-9. McCullum EO, Williams BA, Zhang J, Chaput JC. PMID: 20676978.
      View in: PubMed   Mentions: 26     Fields:    
    71. Creating protein affinity reagents by combining peptide ligands on synthetic DNA scaffolds. J Am Chem Soc. 2009 Dec 02; 131(47):17233-41. Williams BA, Diehnelt CW, Belcher P, Greving M, Woodbury NW, Johnston SA, Chaput JC. PMID: 19894711.
      View in: PubMed   Mentions: 20     Fields:    
    72. A man-made ATP-binding protein evolved independent of nature causes abnormal growth in bacterial cells. PLoS One. 2009 Oct 08; 4(10):e7385. Stomel JM, Wilson JW, León MA, Stafford P, Chaput JC. PMID: 19812699.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    73. Recognition imaging of acetylated chromatin using a DNA aptamer. Biophys J. 2009 Sep 16; 97(6):1804-7. Lin L, Fu Q, Williams BA, Azzaz AM, Shogren-Knaak MA, Chaput JC, Lindsay S. PMID: 19751687.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    74. Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy. J Phys Chem A. 2009 Sep 03; 113(35):9585-7. Lin S, Horning DP, Szostak JW, Chaput JC. PMID: 19673467.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    75. A synthetic protein selected for ligand binding affinity mediates ATP hydrolysis. ACS Chem Biol. 2009 Aug 21; 4(8):649-58. Simmons CR, Stomel JM, McConnell MD, Smith DA, Watkins JL, Allen JP, Chaput JC. PMID: 19522480.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    76. Evolution of a histone H4-K16 acetyl-specific DNA aptamer. J Am Chem Soc. 2009 May 13; 131(18):6330-1. Williams BA, Lin L, Lindsay SM, Chaput JC. PMID: 19385619.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    77. Transcription of an RNA aptamer by a DNA polymerase. Chem Commun (Camb). 2009 May 28; (20):2938-40. McCullum EO, Chaput JC. PMID: 19436916.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    78. Template-directed nucleation and growth of inorganic nanoparticles on DNA scaffolds. Angew Chem Int Ed Engl. 2009; 48(45):8494-6. Stearns LA, Chhabra R, Sharma J, Liu Y, Petuskey WT, Yan H, Chaput JC. PMID: 19795428.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    79. Creating protein biocatalysts as tools for future industrial applications. Expert Opin Biol Ther. 2008 Aug; 8(8):1087-98. Chaput JC, Woodbury NW, Stearns LA, Williams BA. PMID: 18613761.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    80. Searching combinatorial libraries for native proteins with novel folds. Chembiochem. 2008 Jun 16; 9(9):1361-3. Watkins JL, Chaput JC. PMID: 18464233.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    81. Synthesis of two mirror image 4-helix junctions derived from glycerol nucleic acid. J Am Chem Soc. 2008 May 07; 130(18):5846-7. Zhang RS, McCullum EO, Chaput JC. PMID: 18407636.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    82. In vitro selection of histone H4 aptamers for recognition imaging microscopy. J Am Chem Soc. 2007 Nov 28; 129(47):14568-9. Lin L, Hom D, Lindsay SM, Chaput JC. PMID: 17985909.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    83. Experimental evidence that GNA and TNA were not sequential polymers in the prebiotic evolution of RNA. J Mol Evol. 2007 Sep; 65(3):289-95. Yang YW, Zhang S, McCullum EO, Chaput JC. PMID: 17828568.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    84. Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol. 2007 Aug 10; 371(2):501-13. Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. PMID: 17583732.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    85. Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS One. 2007 May 23; 2(5):e467. Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC. PMID: 17520026.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    86. Self-assembled peptide nanoarrays: an approach to studying protein-protein interactions. Angew Chem Int Ed Engl. 2007; 46(17):3051-4. Williams BA, Lund K, Liu Y, Yan H, Chaput JC. PMID: 17361972.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    87. Kinetic analysis of an efficient DNA-dependent TNA polymerase. J Am Chem Soc. 2005 May 25; 127(20):7427-34. Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC. PMID: 15898792.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    88. Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. Chem Biol. 2004 Jun; 11(6):865-74. Chaput JC, Szostak JW. PMID: 15217619.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    89. TNA synthesis by DNA polymerases. J Am Chem Soc. 2003 Aug 06; 125(31):9274-5. Chaput JC, Szostak JW. PMID: 12889939.
      View in: PubMed   Mentions: 22     Fields:    
    90. DNA polymerase-mediated DNA synthesis on a TNA template. J Am Chem Soc. 2003 Jan 29; 125(4):856-7. Chaput JC, Ichida JK, Szostak JW. PMID: 12537469.
      View in: PubMed   Mentions: 22     Fields:    
    91. 5-propynyluracil.diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA. Chem Commun (Camb). 2002 Aug 07; (15):1568-9. Chaput JC, Sinha S, Switzer C. PMID: 12170785.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    92. Probing structure and function with alternative nucleic acids bearing 2',5'-linked, zwitterionic, and isocytosine-isoguanine components. Methods. 2001 Feb; 23(2):141-8. Switzer C, Chaput JC. PMID: 11181033.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    93. Nonenzymatic oligomerization on templates containing phosphodiester-linked acyclic glycerol nucleic acid analogues. J Mol Evol. 2000 Nov; 51(5):464-70. Chaput JC, Switzer C. PMID: 11080369.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    94. RecA protein promotes strand exchange with DNA substrates containing isoguanine and 5-methyl isocytosine. Biochemistry. 2000 Aug 22; 39(33):10177-88. Rice KP, Chaput JC, Cox MM, Switzer C. PMID: 10956007.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    95. Pretreatment expression of the perforin gene by circulating CD8(+) T lymphocytes predicts biochemical response to interferon-alpha in patients with chronic hepatitis C. Eur Cytokine Netw. 2000 Jun; 11(2):177-84. Balian A, Naveau S, Zou W, Durand-Gasselin I, Bouchet L, Foussat A, Galanaud P, Chaput JC, Emilie D. PMID: 10903796.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    96. A DNA pentaplex incorporating nucleobase quintets. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10614-9. Chaput JC, Switzer C. PMID: 10485874.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    97. Beyond guanine quartets: cation-induced formation of homogenous and chimeric DNA tetraplexes incorporating iso-guanine and guanine. Chem Biol. 1997 Dec; 4(12):899-908. Roberts C, Chaput JC, Switzer C. PMID: 9427655.
      View in: PubMed   Mentions: 6     Fields:    
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