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Calof, Anne L.

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentAnatomy and Neurobiology
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-4616, 5745
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    Collapse Research 
    Collapse Research Activities and Funding
    Investigating the multifactorial origins of congenital heart disease
    NIH/NHLBI R01HL138659Aug 15, 2017 - May 31, 2021
    Role: Principal Investigator
    Spatial Dynamics of Tissue and Organ Size Control
    NIH/NINDS R01NS095355Sep 30, 2015 - Jun 30, 2020
    Role: Co-Principal Investigator
    NIPBL, Cohesin and Related Structural Birth Defects
    NIH/NICHD P01HD052860May 1, 2006 - Jan 31, 2016
    Role: Co-Principal Investigator
    FEEDBACK REGULATION OF NEUROGENESIS IN MAMMALS
    NIH/NIDCD R01DC003583Jan 1, 1998 - Mar 31, 2010
    Role: Principal Investigator
    TROPHIC FACTOR CONTROL OF NEURON PRODUCTION AND SURVIVAL
    NIH/NINDS R01NS032174Sep 9, 1993 - Aug 31, 1998
    Role: Principal Investigator
    REGULATION OF NEUROGENESIS
    NIH/NIDCD R01DC002180Sep 1, 1993 - Aug 31, 1997
    Role: Principal Investigator
    MOLECULAR ANALYSIS OF NEUROGENESIS IN A NEUROEPITHELIUM
    NIH/NINDS F32NS008386Jan 1, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Newkirk DA, Chen YY, Chien R, Zeng W, Biesinger J, Flowers E, Kawauchi S, Santos R, Calof A, Lander AD, Xie X, Yokomori K. The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome. Clin Epigenetics. 2017; 9:89. PMID: 28855971.
      View in: PubMed
    2. Kline AD, Krantz ID, Deardorff MA, Shirahige K, Dorsett D, Gerton JL, Wu M, Mehta D, Mills JA, Carrico CS, Noon S, Herrera PS, Horsfield JA, Bettale C, Morgan J, Huisman SA, Moss J, McCleery J, Grados M, Hansen BD, Srivastava S, Taylor-Snell E, Kerr LM, Katz O, Calof A, Musio A, Egense A, Haaland RE. Cornelia de Lange syndrome and molecular implications of the cohesin complex: Abstracts from the 7th biennial scientific and educational symposium 2016. Am J Med Genet A. 2017 May; 173(5):1172-1185. PMID: 28190301.
      View in: PubMed
    3. Santos R, Kawauchi S, Jacobs RE, Lopez-Burks ME, Choi H, Wikenheiser J, Hallgrimsson B, Jamniczky HA, Fraser SE, Lander AD, Calof A. Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol. 2016 Sep; 14(9):e2000197. PMID: 27606604; PMCID: PMC5016002.
    4. Kawauchi S, Santos R, Muto A, Lopez-Burks ME, Schilling TF, Lander AD, Calof A. Using mouse and zebrafish models to understand the etiology of developmental defects in Cornelia de Lange Syndrome. Am J Med Genet C Semin Med Genet. 2016 06; 172(2):138-45. PMID: 27120001.
      View in: PubMed
    5. Lopez-Burks ME, Santos R, Kawauchi S, Calof A, Lander AD. Genetic enhancement of limb defects in a mouse model of Cornelia de Lange syndrome. Am J Med Genet C Semin Med Genet. 2016 06; 172(2):146-54. PMID: 27120109.
      View in: PubMed
    6. Kunche S, Yan H, Calof A, Lowengrub JS, Lander AD. Feedback, Lineages and Self-Organizing Morphogenesis. PLoS Comput Biol. 2016 Mar; 12(3):e1004814. PMID: 26989903; PMCID: PMC4798729.
    7. Chiang M, Hallman S, Cinquin A, de Mochel NR, Paz A, Kawauchi S, Calof A, Cho KW, Fowlkes CC, Cinquin O. Analysis of in vivo single cell behavior by high throughput, human-in-the-loop segmentation of three-dimensional images. BMC Bioinformatics. 2015 Nov 25; 16:397. PMID: 26607933; PMCID: PMC4659165.
    8. Kline AD, Calof A, Lander AD, Gerton JL, Krantz ID, Dorsett D, Deardorff MA, Blagowidow N, Yokomori K, Shirahige K, Santos R, Woodman J, Megee PC, O'Connor JT, Egense A, Noon S, Belote M, Goodban MT, Hansen BD, Timmons JG, Musio A, Ishman SL, Bryan Y, Wu Y, Bettini LR, Mehta D, Zakari M, Mills JA, Srivastava S, Haaland RE. Clinical, developmental and molecular update on Cornelia de Lange syndrome and the cohesin complex: abstracts from the 2014 Scientific and Educational Symposium. Am J Med Genet A. 2015 Jun; 167(6):1179-92. PMID: 25899772.
      View in: PubMed
    9. Muto A, Ikeda S, Lopez-Burks ME, Kikuchi Y, Calof A, Lander AD, Schilling TF. Nipbl and mediator cooperatively regulate gene expression to control limb development. PLoS Genet. 2014 Sep; 10(9):e1004671. PMID: 25255084; PMCID: PMC4177752.
    10. Kline AD, Calof A, Schaaf CA, Krantz ID, Jyonouchi S, Yokomori K, Gauze M, Carrico CS, Woodman J, Gerton JL, Vega H, Levin AV, Shirahige K, Champion M, Goodban MT, O'Connor JT, Pipan M, Horsfield J, Deardorff MA, Ishman SL, Dorsett D. Cornelia de Lange syndrome: further delineation of phenotype, cohesin biology and educational focus, 5th Biennial Scientific and Educational Symposium abstracts. Am J Med Genet A. 2014 Jun; 164A(6):1384-93. PMID: 24504889.
      View in: PubMed
    11. Visnes T, Giordano F, Kuznetsova A, Suja JA, Lander AD, Calof A, Ström L. Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I. Chromosoma. 2014 Jun; 123(3):239-52. PMID: 24287868; PMCID: PMC4031387.
    12. Remeseiro S, Cuadrado A, Kawauchi S, Calof A, Lander AD, Losada A. Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Biochim Biophys Acta. 2013 Dec; 1832(12):2097-102. PMID: 23920377; PMCID: PMC3825806.
    13. Lander AD, Kimble J, Clevers H, Fuchs E, Montarras D, Buckingham M, Calof A, Trumpp A, Oskarsson T. What does the concept of the stem cell niche really mean today? BMC Biol. 2012 Mar 09; 10:19. PMID: 22405133; PMCID: PMC3298504.
    14. Santos R, Wu J, Hamilton JA, Pinter R, Hindges R, Calof A. Restoration of retinal development in Vsx2 deficient mice by reduction of Gdf11 levels. Adv Exp Med Biol. 2012; 723:671-7. PMID: 22183392; PMCID: PMC3790663.
    15. Muto A, Calof A, Lander AD, Schilling TF. Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome. PLoS Biol. 2011 Oct; 9(10):e1001181. PMID: 22039349; PMCID: PMC3201921.
    16. Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof A. Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011 Oct; 138(19):4131-42. PMID: 21852401; PMCID: PMC3171217.
    17. Chien R, Zeng W, Kawauchi S, Bender MA, Santos R, Gregson HC, Schmiesing JA, Newkirk DA, Kong X, Ball AR, Calof A, Lander AD, Groudine MT, Yokomori K. Cohesin mediates chromatin interactions that regulate mammalian ß-globin expression. J Biol Chem. 2011 May 20; 286(20):17870-8. PMID: 21454523; PMCID: PMC3093862.
    18. Chou CS, Lo WC, Gokoffski KK, Zhang YT, Wan FY, Lander AD, Calof A, Nie Q. Spatial dynamics of multistage cell lineages in tissue stratification. Biophys J. 2010 Nov 17; 99(10):3145-54. PMID: 21081061; PMCID: PMC2980753.
    19. Kawauchi S, Calof A, Santos R, Lopez-Burks ME, Young CM, Hoang MP, Chua A, Lao T, Lechner MS, Daniel JA, Nussenzweig A, Kitzes L, Yokomori K, Hallgrimsson B, Lander AD. Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. PLoS Genet. 2009 Sep; 5(9):e1000650. PMID: 19763162; PMCID: PMC2730539.
    20. Kawauchi S, Santos R, Kim J, Hollenbeck PL, Murray RC, Calof A. The role of foxg1 in the development of neural stem cells of the olfactory epithelium. Ann N Y Acad Sci. 2009 Jul; 1170:21-7. PMID: 19686101; PMCID: PMC2878634.
    21. Barlow LA, Calof A. Symposium overview: Stem cells in sensory epithelium development and regeneration. Ann N Y Acad Sci. 2009 Jul; 1170:5-6. PMID: 19686097.
      View in: PubMed
    22. Beites CL, Hollenbeck PL, Kim J, Lovell-Badge R, Lander AD, Calof A. Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue. Development. 2009 Jul; 136(13):2187-97. PMID: 19474151; PMCID: PMC2729339.
    23. Kawauchi S, Kim J, Santos R, Wu HH, Lander AD, Calof A. Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11. Development. 2009 May; 136(9):1453-64. PMID: 19297409; PMCID: PMC2674256.
    24. Lander AD, Gokoffski KK, Wan FY, Nie Q, Calof A. Cell lineages and the logic of proliferative control. PLoS Biol. 2009 Jan 20; 7(1):e15. PMID: 19166268; PMCID: PMC2628408.
    25. Lo WC, Chou CS, Gokoffski KK, Wan FY, Lander AD, Calof A, Nie Q. Feedback regulation in multistage cell lineages. Math Biosci Eng. 2009 Jan; 6(1):59-82. PMID: 19292508; PMCID: PMC2756546.
    26. Beites CL, Kawauchi S, Calof A. Olfactory Neuron Patterning and Specification. Dev Neurobiol. 2009; 7:145-156. PMID: 24817923.
      View in: PubMed
    27. Ogata S, Kawauchi S, Calof A, Cho KW. Plastic embedding and sectioning of Xenopus laevis embryos. J Vis Exp. 2007; (3):188. PMID: 18978994; PMCID: PMC2535840.
    28. Kawauchi S, Shou J, Santos R, Hébert JM, McConnell SK, Mason I, Calof A. Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development. 2005 Dec; 132(23):5211-23. PMID: 16267092.
      View in: PubMed
    29. Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof A. GDF11 controls the timing of progenitor cell competence in developing retina. Science. 2005 Jun 24; 308(5730):1927-30. PMID: 15976303.
      View in: PubMed
    30. Beites CL, Kawauchi S, Crocker CE, Calof A. Identification and molecular regulation of neural stem cells in the olfactory epithelium. Exp Cell Res. 2005 Jun 10; 306(2):309-16. PMID: 15925585.
      View in: PubMed
    31. Krantz ID, McCallum J, DeScipio C, Kaur M, Gillis LA, Yaeger D, Jukofsky L, Wasserman N, Bottani A, Morris CA, Nowaczyk MJ, Toriello H, Bamshad MJ, Carey JC, Rappaport E, Kawauchi S, Lander AD, Calof A, Li HH, Devoto M, Jackson LG. Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B. Nat Genet. 2004 Jun; 36(6):631-5. PMID: 15146186; PMCID: PMC4902017.
    32. Kawauchi S, Beites CL, Crocker CE, Wu HH, Bonnin A, Murray R, Calof A. Molecular signals regulating proliferation of stem and progenitor cells in mouse olfactory epithelium. Dev Neurosci. 2004 Mar-Aug; 26(2-4):166-80. PMID: 15711058.
      View in: PubMed
    33. Murray RC, Navi D, Fesenko J, Lander AD, Calof A. Widespread defects in the primary olfactory pathway caused by loss of Mash1 function. J Neurosci. 2003 Mar 01; 23(5):1769-80. PMID: 12629181.
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    34. Wu HH, Ivkovic S, Murray RC, Jaramillo S, Lyons KM, Johnson JE, Calof A. Autoregulation of neurogenesis by GDF11. Neuron. 2003 Jan 23; 37(2):197-207. PMID: 12546816.
      View in: PubMed
    35. Calof A, Bonnin A, Crocker C, Kawauchi S, Murray RC, Shou J, Wu HH. Progenitor cells of the olfactory receptor neuron lineage. Microsc Res Tech. 2002 Aug 01; 58(3):176-88. PMID: 12203696.
      View in: PubMed
    36. Shou J, Murray RC, Rim PC, Calof A. Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage. Development. 2000 Dec; 127(24):5403-13. PMID: 11076761.
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    37. Murray RC, Tapscott SJ, Petersen JW, Calof A, McCormick MB. A fragment of the Neurogenin1 gene confers regulated expression of a reporter gene in vitro and in vivo. Dev Dyn. 2000 May; 218(1):189-94. PMID: 10822270.
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    38. Calof A. Grant-writing amnesia. Curr Biol. 1999 Dec 02; 9(23):R869. PMID: 10607572.
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    39. Murray RC, Calof A. Neuronal regeneration: lessons from the olfactory system. Semin Cell Dev Biol. 1999 Aug; 10(4):421-31. PMID: 10497099.
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    40. Shou J, Rim PC, Calof A. BMPs inhibit neurogenesis by a mechanism involving degradation of a transcription factor. Nat Neurosci. 1999 Apr; 2(4):339-45. PMID: 10204540.
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    41. Calof A, Rim PC, Askins KJ, Mumm JS, Gordon MK, Iannuzzelli P, Shou J. Factors regulating neurogenesis and programmed cell death in mouse olfactory epithelium. Ann N Y Acad Sci. 1998 Nov 30; 855:226-9. PMID: 9929610.
      View in: PubMed
    42. Calof A, Mumm JS, Rim PC, Shou J. The neuronal stem cell of the olfactory epithelium. J Neurobiol. 1998 Aug; 36(2):190-205. PMID: 9712304.
      View in: PubMed
    43. Mumm JS, Shou J, Calof A. Colony-forming progenitors from mouse olfactory epithelium: evidence for feedback regulation of neuron production. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):11167-72. PMID: 8855327; PMCID: PMC38302.
    44. Calof A, Hagiwara N, Holcomb JD, Mumm JS, Shou J. Neurogenesis and cell death in olfactory epithelium. J Neurobiol. 1996 May; 30(1):67-81. PMID: 8727984.
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    45. Calof A, Holcomb JD, Mumm JS, Haglwara N, Tran P, Smith KM, Shelton D. Factors affecting neuronal birth and death in the mammalian olfactory epithelium. Ciba Found Symp. 1996; 196:188-205; discussion; 205-10. PMID: 8866135.
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    46. Holcomb JD, Mumm JS, Calof A. Apoptosis in the neuronal lineage of the mouse olfactory epithelium: regulation in vivo and in vitro. Dev Biol. 1995 Nov; 172(1):307-23. PMID: 7589810.
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    47. Gordon MK, Mumm JS, Davis RA, Holcomb JD, Calof A. Dynamics of MASH1 expression in vitro and in vivo suggest a non-stem cell site of MASH1 action in the olfactory receptor neuron lineage. Mol Cell Neurosci. 1995 Aug; 6(4):363-79. PMID: 8846005.
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    48. DeHamer MK, Guevara JL, Hannon K, Olwin BB, Calof A. Genesis of olfactory receptor neurons in vitro: regulation of progenitor cell divisions by fibroblast growth factors. Neuron. 1994 Nov; 13(5):1083-97. PMID: 7946347.
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    49. Calof A, Campanero MR, O'Rear JJ, Yurchenco PD, Lander AD. Domain-specific activation of neuronal migration and neurite outgrowth-promoting activities of laminin. Neuron. 1994 Jul; 13(1):117-30. PMID: 8043273.
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    50. Calof A, Lander AD. Relationship between neuronal migration and cell-substratum adhesion: laminin and merosin promote olfactory neuronal migration but are anti-adhesive. J Cell Biol. 1991 Nov; 115(3):779-94. PMID: 1918163; PMCID: PMC2289183.
    51. Calof A, Lander AD, Chikaraishi DM. Regulation of neurogenesis and neuronal differentiation in primary and immortalized cells from mouse olfactory epithelium. Ciba Found Symp. 1991; 160:249-65; discussion 265-76. PMID: 1752166.
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    52. Calof A, Chikaraishi DM. Analysis of neurogenesis in a mammalian neuroepithelium: proliferation and differentiation of an olfactory neuron precursor in vitro. Neuron. 1989 Jul; 3(1):115-27. PMID: 2482777.
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    53. Lander AD, Tomaselli K, Calof A, Reichardt LF. Studies on extracellular matrix components that promote neurite outgrowth. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 2:611-23. PMID: 6586379.
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