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Gupta, Ranjan

Title(s)Professor, Orthopaedic Surgery
Phone(714) 456-1699
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    Collapse Research 
    Collapse Research Activities and Funding
    AAOS Multi-Year Research Symposia for 2011-2015
    NIH/NIAMS R13AR060153Aug 1, 2010 - Jul 31, 2011
    Role: Principal Investigator
    Schwann Cell Control of Chronic Nerve Injury
    NIH/NINDS R01NS049203Aug 15, 2004 - Dec 31, 2014
    Role: Principal Investigator
    TRANSDUCTION OF CHRONIC NERVE INJURY BY SCHWANN CELLS
    NIH/NINDS K08NS002221Sep 30, 2000 - Aug 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zamorano DP, Lim PK, Haghverdian BA, Gupta R. Perioperative Management of the Orthopaedic Patient and Alcohol Use, Abuse, and Withdrawal. J Am Acad Orthop Surg. 2019 Mar 15; 27(6):e249-e257. PMID: 30499892.
      View in: PubMed
    2. Chan JP, Uong J, Nassiri N, Gupta R. Lessons From Leprosy: Peripheral Neuropathies and Deformities in Chronic Demyelinating Diseases. J Hand Surg Am. 2018 Aug 31. PMID: 30177357.
      View in: PubMed
    3. Jung J, Haghverdian B, Gupta R. Proximal Interphalangeal Joint Fusion: Indications and Techniques. Hand Clin. 2018 05; 34(2):177-184. PMID: 29625637.
      View in: PubMed
    4. Ficke JR, Moroski NM, Ross SD, Gupta R. Integrative Medicine as an Adjunct to Orthopaedic Surgery. J Am Acad Orthop Surg. 2018 Jan 15; 26(2):58-65. PMID: 29239871.
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    5. Zhu D, Tapadia MD, Palispis W, Luu M, Wang W, Gupta R. Attenuation of Robust Glial Scar Formation Facilitates Functional Recovery in Animal Models of Chronic Nerve Compression Injury. J Bone Joint Surg Am. 2017 Dec 20; 99(24):e132. PMID: 29257018.
      View in: PubMed
    6. Gupta R. Think Again About That Block: Commentary on an article by Surena Namdari, MD, MSc, et al.: "Randomized Controlled Trial of Interscalene Block Compared with Injectable Liposomal Bupivacaine in Shoulder Arthroplasty". J Bone Joint Surg Am. 2017 04 05; 99(7):e35. PMID: 28375899.
      View in: PubMed
    7. Palispis WA, Gupta R. Surgical repair in humans after traumatic nerve injury provides limited functional neural regeneration in adults. Exp Neurol. 2017 04; 290:106-114. PMID: 28111229.
      View in: PubMed
    8. Lopez G, Martin DF, Wright R, Jung J, Hahn P, Jain N, Bracey DN, Gupta R. Construct Validity for a Cost-effective Arthroscopic Surgery Simulator for Resident Education. J Am Acad Orthop Surg. 2016 Dec; 24(12):886-894. PMID: 27832043.
      View in: PubMed
    9. Jung J, Frump D, Su J, Wang W, Mozaffar T, Gupta R. Desert hedgehog is a mediator of demyelination in compression neuropathies. Exp Neurol. 2015 Sep; 271:84-94. PMID: 25936873.
      View in: PubMed
    10. Lopez G, Wright R, Martin D, Jung J, Bracey D, Gupta R. A cost-effective junior resident training and assessment simulator for orthopaedic surgical skills via fundamentals of orthopaedic surgery: AAOS exhibit selection. J Bone Joint Surg Am. 2015 Apr 15; 97(8):659-66. PMID: 25878310.
      View in: PubMed
    11. Schwarzkopf R, Dang P, Luu M, Mozaffar T, Gupta R. Topical tranexamic Acid does not affect electrophysiologic or neurovascular sciatic nerve markers in an animal model. Clin Orthop Relat Res. 2015 Mar; 473(3):1074-82. PMID: 25560955; PMCID: PMC4317440.
    12. McGarry MH, Nguyen ML, Quigley RJ, Hanypsiak B, Gupta R, Lee TQ. The effect of long and short head biceps loading on glenohumeral joint rotational range of motion and humeral head position. Knee Surg Sports Traumatol Arthrosc. 2016 Jun; 24(6):1979-87. PMID: 25257680.
      View in: PubMed
    13. Raphael DR, Cannesson M, Schwarzkopf R, Garson LM, Vakharia SB, Gupta R, Kain ZN. Total joint Perioperative Surgical Home: an observational financial review. Perioper Med (Lond). 2014; 3:6. PMID: 25177486; PMCID: PMC4149757.
    14. Jung J, Hahn P, Choi B, Mozaffar T, Gupta R. Early Surgical Decompression Restores Neurovascular Blood Flow and Ischemic Parameters in an in Vivo Animal Model of Nerve Compression Injury. J Bone Joint Surg Am. 2014 Jun 04; 96(11):897-906. PMID: 24897737.
      View in: PubMed
    15. Kain ZN, Vakharia S, Garson L, Engwall S, Schwarzkopf R, Gupta R, Cannesson M. The perioperative surgical home as a future perioperative practice model. Anesth Analg. 2014 May; 118(5):1126-30. PMID: 24781578.
      View in: PubMed
    16. Ghert M, Della Rocca GJ, Gupta R, Provencher M, Wolf B, Wolf JM, Yee A. The 2013 American-British-Canadian Traveling Fellowship: innovation, accountability, and insight. J Bone Joint Surg Am. 2014 Apr 16; 96(8):e66. PMID: 24740674.
      View in: PubMed
    17. Campbell ST, Ecklund KJ, Chu EH, McGarry MH, Gupta R, Lee TQ. The role of pectoralis major and latissimus dorsi muscles in a biomechanical model of massive rotator cuff tear. J Shoulder Elbow Surg. 2014 Aug; 23(8):1136-42. PMID: 24560467.
      View in: PubMed
    18. Lopez G, Tornetta P, Mazzocca AD, Stern PJ, Heckmann N, Gupta R. How do you educate someone to have the skills of an orthopaedic surgeon? Instr Course Lect. 2014; 63:487-94. PMID: 24720333.
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    19. Lin MY, Manzano G, Gupta R. Nerve allografts and conduits in peripheral nerve repair. Hand Clin. 2013 Aug; 29(3):331-48. PMID: 23895714.
      View in: PubMed
    20. Berrocal YA, Almeida VW, Gupta R, Levi AD. Transplantation of Schwann cells in a collagen tube for the repair of large, segmental peripheral nerve defects in rats. J Neurosurg. 2013 Sep; 119(3):720-32. PMID: 23746104.
      View in: PubMed
    21. Quigley RJ, Gupta A, Oh JH, Chung KC, McGarry MH, Gupta R, Tibone JE, Lee TQ. Biomechanical comparison of single-row, double-row, and transosseous-equivalent repair techniques after healing in an animal rotator cuff tear model. J Orthop Res. 2013 Aug; 31(8):1254-60. PMID: 23572388.
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    22. Rafijah G, Bowen AJ, Dolores C, Vitali R, Mozaffar T, Gupta R. The effects of adjuvant fibrin sealant on the surgical repair of segmental nerve defects in an animal model. J Hand Surg Am. 2013 May; 38(5):847-55. PMID: 23561728.
      View in: PubMed
    23. Chao T, Frump D, Lin M, Caiozzo VJ, Mozaffar T, Steward O, Gupta R. Matrix metalloproteinase 3 deletion preserves denervated motor endplates after traumatic nerve injury. Ann Neurol. 2013 Feb; 73(2):210-23. PMID: 23281061.
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    24. Lin MY, Frieboes LS, Forootan M, Palispis WA, Mozaffar T, Jafari M, Steward O, Gall CM, Gupta R. Biophysical stimulation induces demyelination via an integrin-dependent mechanism. Ann Neurol. 2012 Jul; 72(1):112-23. PMID: 22829273.
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    25. Nguyen ML, Quigley RJ, Galle SE, McGarry MH, Jun BJ, Gupta R, Burkhart SS, Lee TQ. Margin convergence anchorage to bone for reconstruction of the anterior attachment of the rotator cable. Arthroscopy. 2012 Sep; 28(9):1237-45. PMID: 22608293.
      View in: PubMed
    26. Gupta R, Nassiri N, Hazel A, Bathen M, Mozaffar T. Chronic nerve compression alters Schwann cell myelin architecture in a murine model. Muscle Nerve. 2012 Feb; 45(2):231-41. PMID: 22246880; PMCID: PMC3262776.
    27. Kang JR, Gupta R. Mechanisms of fatty degeneration in massive rotator cuff tears. J Shoulder Elbow Surg. 2012 Feb; 21(2):175-80. PMID: 22244060.
      View in: PubMed
    28. Chao T, Gupta R. Commentary on Kemp et al. (2011): Dose and duration of nerve growth factor (NGF) administration determine the extent of behavioral recovery following peripheral nerve injury in the rat. Exp Neurol. 2012 Mar; 234(1):5-7. PMID: 22222878.
      View in: PubMed
    29. Bederman SS, Rosen CD, Bhatia NN, Kiester PD, Gupta R. Drivers of surgery for the degenerative hip, knee, and spine: a systematic review. Clin Orthop Relat Res. 2012 Apr; 470(4):1090-105. PMID: 21818668; PMCID: PMC3293963.
    30. Kang JR, Zamorano DP, Gupta R. Limb salvage with major nerve injury: current management and future directions. J Am Acad Orthop Surg. 2011; 19 Suppl 1:S28-34. PMID: 21304044.
      View in: PubMed
    31. Rowshan K, Hadley S, Pham K, Caiozzo V, Lee TQ, Gupta R. Development of fatty atrophy after neurologic and rotator cuff injuries in an animal model of rotator cuff pathology. J Bone Joint Surg Am. 2010 Oct 06; 92(13):2270-8. PMID: 20926720; PMCID: PMC2945930.
    32. Frieboes LR, Palispis WA, Gupta R. Nerve compression activates selective nociceptive pathways and upregulates peripheral sodium channel expression in Schwann cells. J Orthop Res. 2010 Jun; 28(6):753-61. PMID: 20014316.
      View in: PubMed
    33. Smith JS, Anderson R, Pham T, Bhatia N, Steward O, Gupta R. Role of early surgical decompression of the intradural space after cervical spinal cord injury in an animal model. J Bone Joint Surg Am. 2010 May; 92(5):1206-14. PMID: 20439667; PMCID: PMC2859904.
    34. Gupta R, Bathen ME, Smith JS, Levi AD, Bhatia NN, Steward O. Advances in the management of spinal cord injury. J Am Acad Orthop Surg. 2010 Apr; 18(4):210-22. PMID: 20357230.
      View in: PubMed
    35. Tapadia M, Mozaffar T, Gupta R. Compressive neuropathies of the upper extremity: update on pathophysiology, classification, and electrodiagnostic findings. J Hand Surg Am. 2010 Apr; 35(4):668-77. PMID: 20223605; PMCID: PMC4715364.
    36. Seiber KS, Savoie FH, McGarry MH, Gupta R, Lee TQ. Biomechanical evaluation of a new reconstruction technique of the ulnar collateral ligament in the elbow with modified bone tunnel placement and interference screw fixation. Clin Biomech (Bristol, Avon). 2010 Jan; 25(1):37-42. PMID: 19837496.
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    37. Frieboes LR, Gupta R. An in-vitro traumatic model to evaluate the response of myelinated cultures to sustained hydrostatic compression injury. J Neurotrauma. 2009 Dec; 26(12):2245-56. PMID: 19645529; PMCID: PMC2824227.
    38. Pham K, Nassiri N, Gupta R. c-Jun, krox-20, and integrin beta4 expression following chronic nerve compression injury. Neurosci Lett. 2009 Nov 13; 465(2):194-8. PMID: 19765400; PMCID: PMC3262774.
    39. Rasouli A, Bhatia N, Dinh P, Cahill K, Suryadevara S, Gupta R. Resection of glial scar following spinal cord injury. J Orthop Res. 2009 Jul; 27(7):931-6. PMID: 19062171; PMCID: PMC2696557.
    40. Schamblin M, Gupta R, Yang BY, McGarry MH, McMaster WC, Lee TQ. In vitro quantitative assessment of total and bipolar shoulder arthroplasties: a biomechanical study using human cadaver shoulders. Clin Biomech (Bristol, Avon). 2009 Oct; 24(8):626-31. PMID: 19501938.
      View in: PubMed
    41. Grumet RC, Hadley S, Diltz MV, Lee TQ, Gupta R. Development of a new model for rotator cuff pathology: the rabbit subscapularis muscle. Acta Orthop. 2009 Feb; 80(1):97-103. PMID: 19234889; PMCID: PMC2823248.
    42. Pham K, Gupta R. Understanding the mechanisms of entrapment neuropathies. Review article. Neurosurg Focus. 2009 Feb; 26(2):E7. PMID: 19435447.
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    43. Dinh P, Hazel A, Palispis W, Suryadevara S, Gupta R. Functional assessment after sciatic nerve injury in a rat model. Microsurgery. 2009; 29(8):644-9. PMID: 19653327.
      View in: PubMed
    44. Mozaffar T, Strandberg E, Abe K, Hilgenberg LG, Smith MA, Gupta R. Neuromuscular junction integrity after chronic nerve compression injury. J Orthop Res. 2009 Jan; 27(1):114-9. PMID: 18655131; PMCID: PMC2670070.
    45. Seiber K, Gupta R, McGarry MH, Safran MR, Lee TQ. The role of the elbow musculature, forearm rotation, and elbow flexion in elbow stability: an in vitro study. J Shoulder Elbow Surg. 2009 Mar-Apr; 18(2):260-8. PMID: 19046641.
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    46. Tafti MA, Cramer SC, Gupta R. Orthopaedic management of the upper extremity of stroke patients. J Am Acad Orthop Surg. 2008 Aug; 16(8):462-70. PMID: 18664635.
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    47. Chao T, Pham K, Steward O, Gupta R. Chronic nerve compression injury induces a phenotypic switch of neurons within the dorsal root ganglia. J Comp Neurol. 2008 Jan 10; 506(2):180-93. PMID: 18022951.
      View in: PubMed
    48. Strandberg EJ, Mozaffar T, Gupta R. The role of neurodiagnostic studies in nerve injuries and other orthopedic disorders. J Hand Surg Am. 2007 Oct; 32(8):1280-90. PMID: 17923316.
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    49. Gupta R, Lee TQ. Contributions of the different rabbit models to our understanding of rotator cuff pathology. J Shoulder Elbow Surg. 2007 Sep-Oct; 16(5 Suppl):S149-57. PMID: 17903710.
      View in: PubMed
    50. Ecklund KJ, Lee TQ, Tibone J, Gupta R. Rotator cuff tear arthropathy. J Am Acad Orthop Surg. 2007 Jun; 15(6):340-9. PMID: 17548883.
      View in: PubMed
    51. Dinh P, Bhatia N, Rasouli A, Suryadevara S, Cahill K, Gupta R. Transplantation of preconditioned Schwann cells following hemisection spinal cord injury. Spine (Phila Pa 1976). 2007 Apr 20; 32(9):943-9. PMID: 17450067.
      View in: PubMed
    52. Gray M, Palispis W, Popovich PG, van Rooijen N, Gupta R. Macrophage depletion alters the blood-nerve barrier without affecting Schwann cell function after neural injury. J Neurosci Res. 2007 Mar; 85(4):766-77. PMID: 17266098.
      View in: PubMed
    53. Shapiro TA, McGarry MH, Gupta R, Lee YS, Lee TQ. Biomechanical effects of glenoid retroversion in total shoulder arthroplasty. J Shoulder Elbow Surg. 2007 May-Jun; 16(3 Suppl):S90-5. PMID: 17169588.
      View in: PubMed
    54. Rasouli A, Bhatia N, Suryadevara S, Cahill K, Gupta R. Transplantation of preconditioned schwann cells in peripheral nerve grafts after contusion in the adult spinal cord. Improvement of recovery in a rat model. J Bone Joint Surg Am. 2006 Nov; 88(11):2400-10. PMID: 17079397.
      View in: PubMed
    55. Berger BL, Gupta R. Demyelination secondary to chronic nerve compression injury alters Schmidt-Lanterman incisures. J Anat. 2006 Jul; 209(1):111-8. PMID: 16822274; PMCID: PMC2100307.
    56. Gupta R, Rummler LS, Palispis W, Truong L, Chao T, Rowshan K, Mozaffar T, Steward O. Local down-regulation of myelin-associated glycoprotein permits axonal sprouting with chronic nerve compression injury. Exp Neurol. 2006 Aug; 200(2):418-29. PMID: 16764860.
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    57. Karamanoukian R, Gupta R, Evans GR. A novel technique for the prophylactic plating of the osteocutaneous radial forearm flap donor site. Ann Plast Surg. 2006 Feb; 56(2):200-4. PMID: 16432333.
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    58. Gupta R, Channual JC. Spatiotemporal pattern of macrophage recruitment after chronic nerve compression injury. J Neurotrauma. 2006 Feb; 23(2):216-26. PMID: 16503805.
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    59. Gupta R, Bingenheimer E, Fornalski S, McGarry MH, Osterman AL, Lee TQ. The effect of ulnar shortening on lunate and triquetrum motion--a cadaveric study. Clin Biomech (Bristol, Avon). 2005 Oct; 20(8):839-45. PMID: 16006023.
      View in: PubMed
    60. Gupta R, Rummler L, Steward O. Understanding the biology of compressive neuropathies. Clin Orthop Relat Res. 2005 Jul; (436):251-60. PMID: 15995449.
      View in: PubMed
    61. Gupta R, Truong L, Bear D, Chafik D, Modafferi E, Hung CT. Shear stress alters the expression of myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) in Schwann cells. J Orthop Res. 2005 Sep; 23(5):1232-9. PMID: 16140204.
      View in: PubMed
    62. Gupta R, Gray M, Chao T, Bear D, Modafferi E, Mozaffar T. Schwann cells upregulate vascular endothelial growth factor secondary to chronic nerve compression injury. Muscle Nerve. 2005 Apr; 31(4):452-60. PMID: 15685607.
      View in: PubMed
    63. Dinh PT, Gupta R. Subtotal medial epicondylectomy as a surgical option for treatment of cubital tunnel syndrome. Tech Hand Up Extrem Surg. 2005 Mar; 9(1):52-9. PMID: 16092820.
      View in: PubMed
    64. Gupta R, Lee TQ. Positional-dependent changes in glenohumeral joint contact pressure and force: possible biomechanical etiology of posterior glenoid wear. J Shoulder Elbow Surg. 2005 Jan-Feb; 14(1 Suppl S):105S-110S. PMID: 15726069.
      View in: PubMed
    65. Kobayashi MR, Brenner KA, Gupta R, Evans GR. Functional biceps brachii reconstruction using the free tensor fasciae latae. Plast Reconstr Surg. 2004 Oct; 114(5):1208-14. PMID: 15457037.
      View in: PubMed
    66. Chafik D, Lee TQ, Gupta R. Total elbow arthroplasty: current indications, factors affecting outcomes, and follow-up results. Am J Orthop (Belle Mead NJ). 2004 Oct; 33(10):496-503. PMID: 15540850.
      View in: PubMed
    67. Azanchi R, Bernal G, Gupta R, Keirstead HS. Combined demyelination plus Schwann cell transplantation therapy increases spread of cells and axonal regeneration following contusion injury. J Neurotrauma. 2004 Jun; 21(6):775-88. PMID: 15253804.
      View in: PubMed
    68. Gupta R, Rowshan K, Chao T, Mozaffar T, Steward O. Chronic nerve compression induces local demyelination and remyelination in a rat model of carpal tunnel syndrome. Exp Neurol. 2004 Jun; 187(2):500-8. PMID: 15144876.
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    69. Fornalski S, Gupta R, Lee TQ. Anatomy and biomechanics of the elbow joint. Tech Hand Up Extrem Surg. 2003 Dec; 7(4):168-78. PMID: 16518218.
      View in: PubMed
    70. Gupta R, Lin YM, Bui P, Chao T, Preston C, Mozaffar T. Macrophage recruitment follows the pattern of inducible nitric oxide synthase expression in a model for carpal tunnel syndrome. J Neurotrauma. 2003 Jul; 20(7):671-80. PMID: 12908928.
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    71. Gupta R, Steward O. Chronic nerve compression induces concurrent apoptosis and proliferation of Schwann cells. J Comp Neurol. 2003 Jun 23; 461(2):174-86. PMID: 12724836.
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    72. Gupta R, Jones NF. A novel method of skeletal fixation in an above-elbow replantation: the dowel pin technique. Plast Reconstr Surg. 2003 Jun; 111(7):2349-52. PMID: 12794480.
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    73. Chafik D, Bear D, Bui P, Patel A, Jones NF, Kim BT, Hung CT, Gupta R. Optimization of Schwann cell adhesion in response to shear stress in an in vitro model for peripheral nerve tissue engineering. Tissue Eng. 2003 Apr; 9(2):233-41. PMID: 12740086.
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    74. Gupta R, Allaire RB, Fornalski S, Osterman AL, Lee TQ. Kinematic analysis of the distal radioulnar joint after a simulated progressive ulnar-sided wrist injury. J Hand Surg Am. 2002 Sep; 27(5):854-62. PMID: 12239676.
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