Nicole Renee Sparks

Title(s)Assistant Professor, Ctr For Occup & Environ Health
SchoolUC Irvine Joe C. Wen School of Population & Public Health
Address856 Health Sciences Quad
University of California, Irvine
Irvine CA 92697-3957
Phone(949) 824-2932
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    Collapse research activities and funding
    Epigenetic Regulation in Human Embryonic Stem Cell Lineage Specification
    NIH R35GM157321Sep 1, 2025 - Jun 30, 2030
    Role: Principal Investigator
    Analysis of environmentally-sensitive epigenetic machinery during osteogenic differentiation
    NIH R00ES032486Dec 15, 2020 - Aug 31, 2025
    Role: Principal Investigator
    Analysis of environmentally-sensitive epigenetic machinery during osteogenic differentiation
    NIH K99ES032486Dec 15, 2020 - Nov 30, 2022
    Role: Principal Investigator

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    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. MicroRNA network regulation of developmental bone toxicity in a human embryonic stem cell osteogenic model. NAM J. 2026; 2:100108. Schwartz AV, Williams D, Zepeda MH, Bertotto LB, George UZ, Zur Nieden NI, Sparks NRL. PMID: 42436712; PMCID: PMC13355823.
      View in: PubMed   Mentions:
    2. Airborne contaminant exposure and bone development: a systematic review and meta-analysis. Toxicol Sci. 2026 Jun 05; 209(6). Vera-Colón MKM, Meletz RM, Phillipson CN, Sparks NRL. PMID: 42233341; PMCID: PMC13283646.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsPHPublic Health
    3. Endocrine Disruptor-Induced Bone Damage Due to Hormone Dysregulation: A Review. Int J Mol Sci. 2023 May 05; 24(9). Iwobi N, Sparks NR. PMID: 37175969; PMCID: PMC10179611.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    4. Sidestream Smoke Extracts from Harm-Reduction and Conventional Camel Cigarettes Inhibit Osteogenic Differentiation via Oxidative Stress and Differential Activation of intrinsic Apoptotic Pathways. Antioxidants (Basel). 2022 Dec 15; 11(12). Sparks NRL, Walker LM, Sera SR, Madrid JV, Hanna M, Dominguez EC, Zur Nieden NI. PMID: 36552682; PMCID: PMC9774253.
      View in: PubMed   Mentions: 6  
    5. Exposure to Cigarette Smoke Impedes Human Osteoblast Differentiation Independently of Nicotine. Nicotine Tob Res. 2022 11 12; 24(12):1921-1926. Martinez IKC, Sparks NRL, Madrid JV, Talbot P, Zur Nieden NI. PMID: 35778911.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. An Evaluation of Human Induced Pluripotent Stem Cells to Test for Cardiac Developmental Toxicity. Int J Mol Sci. 2021 Jul 29; 22(15). Walker LM, Sparks NRL, Puig-Sanvicens V, Rodrigues B, Zur Nieden NI. PMID: 34360880; PMCID: PMC8347148.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    7. Maternal-to-zygotic transition as a potential target for niclosamide during early embryogenesis. Toxicol Appl Pharmacol. 2019 10 01; 380:114699. Vliet SMF, Dasgupta S, Sparks NRL, Kirkwood JS, Vollaro A, Hur M, Zur Nieden NI, Volz DC. PMID: 31398420; PMCID: PMC6717554.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    8. Video-based kinetic analysis of calcification in live osteogenic human embryonic stem cell cultures reveals the developmentally toxic effect of Snus tobacco extract. Toxicol Appl Pharmacol. 2019 01 15; 363:111-121. Martinez IKC, Sparks NRL, Madrid JV, Affeldt H, Vera MKM, Bhanu B, Zur Nieden NI. PMID: 30468815; PMCID: PMC6594699.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Low Osteogenic Yield in Human Pluripotent Stem Cells Associates with Differential Neural Crest Promoter Methylation. Stem Cells. 2018 03; 36(3):349-362. Sparks NRL, Martinez IKC, Soto CH, Zur Nieden NI. PMID: 29193426; PMCID: PMC5998661.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    10. Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage. Methods Mol Biol. 2018; 1797:125-145. Madrid JV, Sera SR, Sparks NRL, Zur Nieden NI. PMID: 29896689.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Glucose-Induced Oxidative Stress Reduces Proliferation in Embryonic Stem Cells via FOXO3A/β-Catenin-Dependent Transcription of p21(cip1). Stem Cell Reports. 2016 07 12; 7(1):55-68. McClelland Descalzo DL, Satoorian TS, Walker LM, Sparks NR, Pulyanina PY, Zur Nieden NI. PMID: 27411103; PMCID: PMC4945584.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    12. Wnt5a Supports Osteogenic Lineage Decisions in Embryonic Stem Cells. Stem Cells Dev. 2016 07 01; 25(13):1020-32. Keller KC, Ding H, Tieu R, Sparks NR, Ehnes DD, Zur Nieden NI. PMID: 26956615.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    13. Functional and morphological plasticity of crocodile (Crocodylus porosus) salt glands. J Exp Biol. 2008 May; 211(Pt 9):1482-9. Cramp RL, Meyer EA, Sparks N, Franklin CE. PMID: 18424682.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
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