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Young Jik Kwon

Title(s)Professor, Pharmaceutical Sciences
SchoolSchool of Pharmacy and Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-8714
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Correction: Assessment of AAV/polyketal chimeric nanoparticles for ocular gene transduction using an animal model. Drug Deliv Transl Res. 2026 Apr; 16(4):1332. Castro BFM, Lugin M, Guerra MCA, Dias MF, Lee RT, Silva-Cunha A, Kwon YJ, Fialho SL. PMID: 41545811.
      View in: PubMed   Mentions:
    2. GENRISE-induced superior extracellular vesicles for scalable therapeutic cargo delivery. Sci Adv. 2025 Oct 24; 11(43):eady9680. Kim H, Moon S, Kim D, Jeong IH, An EK, Park HB, Jin SM, Ji Y, Ko O, Min JH, Lee H, Lee E, Kwon YJ, Jin JO, Lee PCW, Lee JB. PMID: 41124251; PMCID: PMC12542945.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Assessment of AAV/polyketal chimeric nanoparticles for ocular gene transduction using an animal model. Drug Deliv Transl Res. 2026 Apr; 16(4):1319-1331. Castro BFM, Lugin M, Guerra MCA, Dias MF, Lee RT, Silva-Cunha A, Kwon YJ, Fialho SL. PMID: 41120778.
      View in: PubMed   Mentions:
    4. RSK2 and its binding partners: an emerging signaling node in cancers. Arch Pharm Res. 2025 May; 48(5):365-383. Lee HS, Cho SJ, Kang HC, Lee JY, Kwon YJ, Cho YY. PMID: 40320503.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Autophagic Cell Survival-to-Death Switch Induced by Cisplatin and Zn(II) Dual-Loaded Dispersity-Tunable Zwitterionic Hybrid Polyion Nanocomplex. ACS Appl Mater Interfaces. 2025 Apr 23; 17(16):23774-23785. Cho H, Choi M, Park JM, Choi J, Kwon YJ, Lee SM, Kang HC. PMID: 40226983.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Karyoptosis as a novel type of UVB-induced regulated cell death. Free Radic Res. 2024 Nov; 58(11):796-810. Chen W, Byun J, Kang HC, Lee HS, Lee JY, Kwon YJ, Cho YY. PMID: 39625813.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    7. SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death. Cell Mol Life Sci. 2024 Nov 14; 81(1):451. Lee GE, Bang G, Byun J, Chen W, Jeung D, Cho H, Lee JY, Kang HC, Lee HS, Kim JY, Kim KD, Wu J, Nam SB, Kwon YJ, Lee CJ, Cho YY. PMID: 39540935; PMCID: PMC11564579.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Administration sequence- and formation-dependent vaccination using acid-degradable polymeric nanoparticles with high antigen encapsulation capability. J Mater Chem B. 2024 Jul 10; 12(27):6577-6586. Choi YS, Felgner J, Jan S, Hernandez-Davies JE, Davies DH, Kwon YJ. PMID: 38872501.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsPHPublic Health
    9. Selective delivery of imaging probes and therapeutics to the endoplasmic reticulum or Golgi apparatus: Current strategies and beyond. Adv Drug Deliv Rev. 2024 09; 212:115386. Cho H, Huh KM, Shim MS, Cho YY, Lee JY, Lee HS, Kwon YJ, Kang HC. PMID: 38971180.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting. Biomater Sci. 2024 Jun 11; 12(12):3045-3067. Cho H, Huh KM, Cho HJ, Kim B, Shim MS, Cho YY, Lee JY, Lee HS, Kwon YJ, Kang HC. PMID: 38712883.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    11. Analyzing indirect economic impacts of wildfire damages on regional economies. Risk Anal. 2023 Dec; 43(12):2631-2643. Kim E, Kwon YJ. PMID: 36813702.
      View in: PubMed   Mentions: 1     Fields:    
    12. Vaccination against SARS-CoV-2 using extracellular blebs derived from spike protein-expressing dendritic cells. Cell Immunol. 2023 04; 386:104691. Young Chung J, Thone MN, Davies JE, Gach JS, Huw Davies D, Forthal DN, Kwon YJ. PMID: 36822152; PMCID: PMC9933546.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsPHPublic Health
    13. Nanocomplexes of doxorubicin and DNA fragments for efficient and safe cancer chemotherapy. J Control Release. 2023 02; 354:91-108. Mohammad SN, Choi YS, Chung JY, Cedrone E, Neun BW, Dobrovolskaia MA, Yang X, Guo W, Chew YC, Kim J, Baek S, Kim IS, Fruman DA, Kwon YJ. PMID: 36572154; PMCID: PMC12710500.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. Cell-free, Dendritic Cell-mimicking Extracellular Blebs for Molecularly Controlled Vaccination. Adv Ther (Weinh). 2023 Jan; 6(1). Thone MN, Chung JY, Ingato D, Lugin ML, Kwon YJ. PMID: 36733607; PMCID: PMC9888466.
      View in: PubMed   Mentions: 1  
    15. Cancer nanotechnology: current status and perspectives. Nano Converg. 2021 Nov 02; 8(1):34. Kemp JA, Kwon YJ. PMID: 34727233; PMCID: PMC8560887.
      View in: PubMed   Mentions: 76  
    16. Eradication of Intracellular Salmonella Typhimurium by Polyplexes of Acid-Transforming Chitosan and Fragment DNA. Macromol Biosci. 2021 07; 21(7):e2000408. Edson JA, Chu W, Porwollik S, Tran K, Iribe N, McClelland M, Kwon YJ. PMID: 33870627; PMCID: PMC8295212.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    17. COVID-19: An unprecedented challenge and an opportunity for change. Adv Drug Deliv Rev. 2021 04; 171:48-49. Kwon YJ, Forthal D. PMID: 33524417; PMCID: PMC7845530.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    18. COVID-19 vaccines: The status and perspectives in delivery points of view. Adv Drug Deliv Rev. 2021 03; 170:1-25. Chung JY, Thone MN, Kwon YJ. PMID: 33359141; PMCID: PMC7759095.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimalsCells
    19. Solvent-driven, self-assembled acid-responsive poly(ketalized serine)/siRNA complexes for RNA interference. Biomater Sci. 2020 Dec 07; 8(23):6718-6729. Wong S, Kemp JA, Shim MS, Kwon YJ. PMID: 33111729.
      View in: PubMed   Mentions: 1     Fields:    
    20. Extracellular vesicles (EVs): Comprehensive packages with promises and complications for clinical translation and commercialization. Methods. 2020 05 01; 177:1. Kwon YJ. PMID: 32145390.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. Design and synthesis of multigrain nanocrystals via geometric misfit strain. Nature. 2020 01; 577(7790):359-363. Oh MH, Cho MG, Chung DY, Park I, Kwon YP, Ophus C, Kim D, Kim MG, Jeong B, Gu XW, Jo J, Yoo JM, Hong J, McMains S, Kang K, Sung YE, Alivisatos AP, Hyeon T. PMID: 31942056.
      View in: PubMed   Mentions: 24     Fields:    
    22. Extracellular blebs: Artificially-induced extracellular vesicles for facile production and clinical translation. Methods. 2020 05 01; 177:135-145. Thone MN, Kwon YJ. PMID: 31734187.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    23. Cancer Cell-Derived, Drug-Loaded Nanovesicles Induced by Sulfhydryl-Blocking for Effective and Safe Cancer Therapy. ACS Nano. 2018 09 25; 12(9):9568-9577. Ingato D, Edson JA, Zakharian M, Kwon YJ. PMID: 30130093.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    24. Corrigendum to molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspective progress in retinal and eye research (2018) Vol 63,107-131. Prog Retin Eye Res. 2018 09; 66:220-221. Dias MF, Joo K, Kemp JA, Fialho SL, da Silva Cunha A, Woo SJ, Kwon YJ. PMID: 30104149.
      View in: PubMed   Mentions: 3     Fields:    
    25. Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography. Nano Converg. 2018; 5(1):3. Kim CS, Ingato D, Wilder-Smith P, Chen Z, Kwon YJ. PMID: 29399435; PMCID: PMC5785591.
      View in: PubMed   Mentions: 12  
    26. Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives. Prog Retin Eye Res. 2018 03; 63:107-131. Dias MF, Joo K, Kemp JA, Fialho SL, da Silva Cunha A, Woo SJ, Kwon YJ. PMID: 29097191.
      View in: PubMed   Mentions: 232     Fields:    Translation:Humans
    27. Design, challenge, and promise of stimuli-responsive nanoantibiotics. Nano Converg. 2016; 3(1):26. Edson JA, Kwon YJ. PMID: 28191436; PMCID: PMC5271158.
      View in: PubMed   Mentions: 8  
    28. Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery. J Control Release. 2016 11 10; 241:174-185. Ingato D, Lee JU, Sim SJ, Kwon YJ. PMID: 27667180.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    29. Viral/Nonviral Chimeric Nanoparticles To Synergistically Suppress Leukemia Proliferation via Simultaneous Gene Transduction and Silencing. ACS Nano. 2016 09 27; 10(9):8705-14. Hong CA, Cho SK, Edson JA, Kim J, Ingato D, Pham B, Chuang A, Fruman DA, Kwon YJ. PMID: 27472284; PMCID: PMC5602606.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    30. Aptamers: The "evolution" of SELEX. Methods. 2016 08 15; 106:21-8. Wu YX, Kwon YJ. PMID: 27109056.
      View in: PubMed   Mentions: 51     Fields:    
    31. "Combo" nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy. Adv Drug Deliv Rev. 2016 Mar 01; 98:3-18. Kemp JA, Shim MS, Heo CY, Kwon YJ. PMID: 26546465.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimals
    32. RNAi for silencing drug resistance in microbes toward development of nanoantibiotics. J Control Release. 2014 Sep 10; 189:150-7. Edson JA, Kwon YJ. PMID: 24995951.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    33. Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene. J Neurooncol. 2014 May; 118(1):29-37. Wang F, Zamora G, Sun CH, Trinidad A, Chun C, Kwon YJ, Berg K, Madsen SJ, Hirschberg H. PMID: 24610460; PMCID: PMC4153358.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier. J Biomed Opt. 2014; 19(10):105009. Zamora G, Wang F, Sun CH, Trinidad A, Kwon YJ, Cho SK, Berg K, Madsen SJ, Hirschberg H. PMID: 25341069; PMCID: PMC4206751.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    35. Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications. J Mater Chem B. 2014 Feb 14; 2(6):595-615. Wong S, Shim MS, Kwon YJ. PMID: 32261276.
      View in: PubMed   Mentions: 15     Fields:    
    36. Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD). Biomaterials. 2013 Dec; 34(38):10228-37. Cho SK, Pedram A, Levin ER, Kwon YJ. PMID: 24055523; PMCID: PMC3989112.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    37. Glioma cell growth inhibition following photochemical internalization enhanced non-viral PTEN gene transfection. Lasers Surg Med. 2012 Nov; 44(9):746-54. Mathews MS, Shih EC, Zamora G, Sun CH, Cho SK, Kwon YJ, Hirschberg H. PMID: 23018764; PMCID: PMC4141883.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    38. Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications. Adv Drug Deliv Rev. 2012 Aug; 64(11):1046-59. Shim MS, Kwon YJ. PMID: 22329941.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    39. Simultaneous gene transduction and silencing using stimuli-responsive viral/nonviral chimeric nanoparticles. Biomaterials. 2012 Apr; 33(11):3316-23. Cho SK, Kwon YJ. PMID: 22281425.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    40. Before and after endosomal escape: roles of stimuli-converting siRNA/polymer interactions in determining gene silencing efficiency. Acc Chem Res. 2012 Jul 17; 45(7):1077-88. Kwon YJ. PMID: 22103667.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    41. "Nanoantibiotics": a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era. J Control Release. 2011 Dec 10; 156(2):128-45. Huh AJ, Kwon YJ. PMID: 21763369.
      View in: PubMed   Mentions: 432     Fields:    Translation:HumansAnimalsCells
    42. Dual mode polyspermine with tunable degradability for plasmid DNA and siRNA delivery. Biomaterials. 2011 Jun; 32(16):4009-20. Shim MS, Kwon YJ. PMID: 21371749.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    43. Synthetically functionalized retroviruses produced from the bioorthogonally engineered cell surface. Bioconjug Chem. 2011 Feb 16; 22(2):151-5. Wong S, Kwon YJ. PMID: 21280590.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    44. Polyamine/DNA polyplexes with acid-degradable polymeric shell as structurally and functionally virus-mimicking nonviral vectors. J Control Release. 2011 Mar 30; 150(3):287-97. Cho SK, Kwon YJ. PMID: 21167887.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    45. Efficient and targeted delivery of siRNA in vivo. FEBS J. 2010 Dec; 277(23):4814-27. Shim MS, Kwon YJ. PMID: 21078116.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    46. Dynamics of nucleic acid/cationic polymer complexation and disassembly under biologically simulated conditions using in situ atomic force microscopy. Microsc Res Tech. 2010 Sep; 73(9):845-56. Shim MS, Wang X, Ragan R, Kwon YJ. PMID: 20803694; PMCID: PMC2931358.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    47. Combined multimodal optical imaging and targeted gene silencing using stimuli-transforming nanotheragnostics. J Am Chem Soc. 2010 Jun 23; 132(24):8316-24. Shim MS, Kim CS, Ahn YC, Chen Z, Kwon YJ. PMID: 20518502; PMCID: PMC2903751.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    48. Separation and recovery of nucleic acids with improved biological activity by acid-degradable polyacrylamide gel electrophoresis. Electrophoresis. 2010 May; 31(10):1656-61. Kim YK, Kwon YJ. PMID: 20419706.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Acid-transforming polypeptide micelles for targeted nonviral gene delivery. Biomaterials. 2010 Apr; 31(12):3404-13. Shim MS, Kwon YJ. PMID: 20122722.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    50. Isolation of intact proteins from acid-degradable polyacrylamide gel. Proteomics. 2009 Jul; 9(14):3765-71. Kim YK, Kwon YJ. PMID: 19609972.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    51. Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles. J Biomed Opt. 2009 May-Jun; 14(3):034008. Kim CS, Wilder-Smith P, Ahn YC, Liaw LH, Chen Z, Kwon YJ. PMID: 19566301; PMCID: PMC2872553.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    52. Differential interaction of retroviral vector with target cell: quantitative effect of cellular receptor, soluble proteoglycan, and cell type on gene delivery efficiency. Tissue Eng Part A. 2008 Sep; 14(9):1497-506. Kwon YJ, Peng CA. PMID: 18620488.
      View in: PubMed   Mentions:    Fields:    
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