Cocco, Melanie

InstitutionUniversity of California, Irvine
DepartmentMolecular Biology & Biochemistry
Address1218 Natural Sciences 1
Zot 3900
Irvine CA 92697
Phone(949) 824-4487, 9043
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    Collapse Research 
    Collapse Research Activities and Funding
    Trapping membrane proteins with adjuvant-carrying amphipols for vaccine formulati
    NIH/NIAID R01AI092129Sep 1, 2011 - Aug 31, 2015
    Role: Co-Principal Investigator
    pH-Triggered Membrane Insertion of Proteins
    NIH/NIGMS R01GM069783Aug 1, 2004 - Jul 31, 2015
    Role: Co-Principal Investigator
    NIH/NIAMS F32AR008445Mar 24, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Moro SL, Cocco MJ. (1)H, (13)C, and (15)N backbone resonance assignments of the full-length 40 kDa S. acidocaldarius Y-family DNA polymerase, dinB homolog. Biomol NMR Assign. 2015 Oct; 9(2):441-5. PMID: 26154586.
      View in: PubMed
    2. Feinstein HE, Tifrea D, Sun G, Popot JL, de la Maza LM, Cocco MJ. Long-term stability of a vaccine formulated with the amphipol-trapped major outer membrane protein from Chlamydia trachomatis. J Membr Biol. 2014 Oct; 247(9-10):1053-65. PMID: 24942817; PMCID: PMC4198661.
    3. Alhoshani A, Vithayathil R, Bandong J, Chrunyk KM, Moreno GO, Weiss GA, Cocco MJ. Glutamate provides a key structural contact between reticulon-4 (Nogo-66) and phosphocholine. Biochim Biophys Acta. 2014 Sep; 1838(9):2350-6. PMID: 24863057; PMCID: PMC4098973.
    4. Tifrea DF, Pal S, Popot JL, Cocco MJ, de la Maza LM. Increased immunoaccessibility of MOMP epitopes in a vaccine formulated with amphipols may account for the very robust protection elicited against a vaginal challenge with Chlamydia muridarum. J Immunol. 2014 Jun 01; 192(11):5201-13. PMID: 24778450; PMCID: PMC4030638.
    5. Vithayathil R, Hooy RM, Cocco MJ, Weiss GA. The scope of phage display for membrane proteins. J Mol Biol. 2011 Dec 09; 414(4):499-510. PMID: 22037583; PMCID: PMC3230673.
    6. Moody CL, Tretyachenko-Ladokhina V, Laue TM, Senear DF, Cocco MJ. Multiple conformations of the cytidine repressor DNA-binding domain coalesce to one upon recognition of a specific DNA surface. Biochemistry. 2011 Aug 09; 50(31):6622-32. PMID: 21688840.
      View in: PubMed
    7. Tifrea DF, Sun G, Pal S, Zardeneta G, Cocco MJ, Popot JL, de la Maza LM. Amphipols stabilize the Chlamydia major outer membrane protein and enhance its protective ability as a vaccine. Vaccine. 2011 Jun 20; 29(28):4623-31. PMID: 21550371; PMCID: PMC3114171.
    8. Corbin-Lickfett KA, Souki SK, Cocco MJ, Sandri-Goldin RM. Three arginine residues within the RGG box are crucial for ICP27 binding to herpes simplex virus 1 GC-rich sequences and for efficient viral RNA export. J Virol. 2010 Jul; 84(13):6367-76. PMID: 20410270; PMCID: PMC2903288.
    9. Vasudevan SV, Schulz J, Zhou C, Cocco MJ. Protein folding at the membrane interface, the structure of Nogo-66 requires interactions with a phosphocholine surface. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):6847-51. PMID: 20351248; PMCID: PMC2872388.
    10. Corbin-Lickfett KA, Rojas S, Li L, Cocco MJ, Sandri-Goldin RM. ICP27 phosphorylation site mutants display altered functional interactions with cellular export factors Aly/REF and TAP/NXF1 but are able to bind herpes simplex virus 1 RNA. J Virol. 2010 Mar; 84(5):2212-22. PMID: 20015986; PMCID: PMC2820919.
    11. Corbin-Lickfett KA, Chen IH, Cocco MJ, Sandri-Goldin RM. The HSV-1 ICP27 RGG box specifically binds flexible, GC-rich sequences but not G-quartet structures. Nucleic Acids Res. 2009 Nov; 37(21):7290-301. PMID: 19783816; PMCID: PMC2790906.
    12. Llenado RA, Weeks CS, Cocco MJ, Ouellette AJ. Electropositive charge in alpha-defensin bactericidal activity: functional effects of Lys-for-Arg substitutions vary with the peptide primary structure. Infect Immun. 2009 Nov; 77(11):5035-43. PMID: 19737896; PMCID: PMC2772546.
    13. Sasaki H, Arai H, Cocco MJ, White SH. pH dependence of sphingosine aggregation. Biophys J. 2009 Apr 08; 96(7):2727-33. PMID: 19348755; PMCID: PMC2711282.
    14. Vasudevan S, Yuan J, Osapay G, Tran P, Tai K, Liang W, Kumar V, Selsted ME, Cocco MJ. Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque. J Biol Chem. 2008 Dec 19; 283(51):35869-77. PMID: 18930922; PMCID: PMC2602889.
    15. Gehman JD, Cocco MJ, Grindley ND. Chemical shift mapping of gammadelta resolvase dimer and activated tetramer: mechanistic implications for DNA strand exchange. Biochim Biophys Acta. 2008 Dec; 1784(12):2086-92. PMID: 18840551.
      View in: PubMed
    16. Liu D, Ren D, Huang H, Dankberg J, Rosenfeld R, Cocco MJ, Li L, Brems DN, Remmele RL. Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation. Biochemistry. 2008 May 06; 47(18):5088-100. PMID: 18407665.
      View in: PubMed
    17. Liu D, Cocco MJ, Rosenfied R, Lewis JK, Ren D, Li L, Remmele RL, Brems DN. Assignment of backbone (1)H, (13)C and (15)N resonances of human IgG1 Fc (51.4 kDa). Biomol NMR Assign. 2007 Dec; 1(2):233-5. PMID: 19636873.
      View in: PubMed
    18. Liu D, Cocco M, Matsumura M, Ren D, Becker B, Remmele RL, Brems DN. Assignment of 1H, 13C and 15N resonances of the reduced human IgG1 C(H)3 domain. Biomol NMR Assign. 2007 Jul; 1(1):93-4. PMID: 19636836.
      View in: PubMed
    19. Sun G, Pal S, Sarcon AK, Kim S, Sugawara E, Nikaido H, Cocco MJ, Peterson EM, de la Maza LM. Structural and functional analyses of the major outer membrane protein of Chlamydia trachomatis. J Bacteriol. 2007 Sep; 189(17):6222-35. PMID: 17601785; PMCID: PMC1951919.
    20. Tretyachenko-Ladokhina V, Cocco MJ, Senear DF. Flexibility and adaptability in binding of E. coli cytidine repressor to different operators suggests a role in differential gene regulation. J Mol Biol. 2006 Sep 15; 362(2):271-86. PMID: 16919681.
      View in: PubMed
    21. Weeks CS, Tanabe H, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco MJ, Ouellette AJ. Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity. J Biol Chem. 2006 Sep 29; 281(39):28932-42. PMID: 16822871.
      View in: PubMed
    22. Levin AM, Coroneus JG, Cocco MJ, Weiss GA. Exploring the interaction between the protein kinase A catalytic subunit and caveolin-1 scaffolding domain with shotgun scanning, oligomer complementation, NMR, and docking. Protein Sci. 2006 Mar; 15(3):478-86. PMID: 16452625; PMCID: PMC2249769.
    23. Tanabe H, Ouellette AJ, Cocco MJ, Robinson WE. Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. J Virol. 2004 Nov; 78(21):11622-31. PMID: 15479803; PMCID: PMC523300.
    24. Cortajarena AL, Kajander T, Pan W, Cocco MJ, Regan L. Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins. Protein Eng Des Sel. 2004 Apr; 17(4):399-409. PMID: 15166314.
      View in: PubMed
    25. Cocco MJ, Hanakahi LA, Huber MD, Maizels N. Specific interactions of distamycin with G-quadruplex DNA. Nucleic Acids Res. 2003 Jun 01; 31(11):2944-51. PMID: 12771220; PMCID: PMC156726.
    26. Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L. Design of stable alpha-helical arrays from an idealized TPR motif. Structure. 2003 May; 11(5):497-508. PMID: 12737816.
      View in: PubMed
    27. Ramírez-Alvarado M, Cocco MJ, Regan L. Mutations in the B1 domain of protein G that delay the onset of amyloid fibril formation in vitro. Protein Sci. 2003 Mar; 12(3):567-76. PMID: 12592027; PMCID: PMC2312443.