Sean B Ostlund

Title(s)Associate Professor, Anesthesiology and Perioperative Care
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-1347, 9826
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    Nucleus accumbens circuits for regulating cue-motivated behavior
    NIH R01MH126285Apr 2, 2021 - Jan 31, 2026
    Role: Principal Investigator
    Interactions between orbitofrontal cortex and mediodorsal thalamus in cue- and value-based decision making
    NIH R21DA046667Sep 30, 2020 - Aug 31, 2022
    Role: Principal Investigator
    Identifying motivational decision making deficits underlying the apathy domain in a rat model of Alzheimers disease
    NIH R21AG060752Feb 1, 2019 - Nov 30, 2021
    Role: Co-Principal Investigator
    Cholinergic regulation of striatal neurochemistry in cue-triggered decision-making
    NIH R01MH106972Apr 15, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Neurochemical bases for changes in decision-making across the lifespan
    NIH R01AG045380Aug 1, 2014 - May 31, 2020
    Role: Co-Principal Investigator
    Cafeteria diet-induced dysregulation of food seeking: neurochemical bases
    NIH R01DK098709May 1, 2014 - Apr 30, 2018
    Role: Co-Principal Investigator
    Cocaine-Seeking and the Transfer of Behavioral Control
    NIH R01DA029035Feb 1, 2011 - Nov 30, 2017
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behavior. bioRxiv. 2023 Sep 15. Halbout B, Hutson C, Agrawal S, Springs ZA, Ostlund SB. PMID: 37745601; PMCID: PMC10515939.
      View in: PubMed   Mentions:
    2. Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats. Psychopharmacology (Berl). 2023 May; 240(5):1151-1167. Halbout B, Hutson C, Hua L, Inshishian V, Mahler SV, Ostlund SB. PMID: 36933028; PMCID: PMC10102061.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    3. Flexible control of Pavlovian-instrumental transfer based on expected reward value. J Exp Psychol Anim Learn Cogn. 2023 Jan; 49(1):14-30. Marshall AT, Halbout B, Munson CN, Hutson C, Ostlund SB. PMID: 36795420; PMCID: PMC10561628.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Dorsomedial prefrontal cortex activation disrupts Pavlovian incentive motivation. Front Behav Neurosci. 2022; 16:999320. Halbout B, Hutson C, Wassum KM, Ostlund SB. PMID: 36311857; PMCID: PMC9608868.
      View in: PubMed   Mentions:
    5. Reward-predictive cues elicit excessive reward seeking in adolescent rats. Dev Cogn Neurosci. 2020 10; 45:100838. Marshall AT, Munson CN, Maidment NT, Ostlund SB. PMID: 32846387; PMCID: PMC7451619.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    6. The push and pull of dopamine in cue-reward learning. Learn Behav. 2019 12; 47(4):273-274. Ostlund SB. PMID: 30737730; PMCID: PMC6687573.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats. Elife. 2019 05 20; 8. Halbout B, Marshall AT, Azimi A, Liljeholm M, Mahler SV, Wassum KM, Ostlund SB. PMID: 31107241; PMCID: PMC6548499.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    8. Nucleus Accumbens Cholinergic Interneurons Oppose Cue-Motivated Behavior. Biol Psychiatry. 2019 09 01; 86(5):388-396. Collins AL, Aitken TJ, Huang IW, Shieh C, Greenfield VY, Monbouquette HG, Ostlund SB, Wassum KM. PMID: 30955842; PMCID: PMC7003647.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    9. Repeated cocaine exposure dysregulates cognitive control over cue-evoked reward-seeking behavior during Pavlovian-to-instrumental transfer. Learn Mem. 2018 09; 25(9):399-409. Marshall AT, Ostlund SB. PMID: 30115761; PMCID: PMC6097769.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    10. Junk Food Exposure Disrupts Selection of Food-Seeking Actions in Rats. Front Psychiatry. 2018; 9:350. Kosheleff AR, Araki J, Tsan L, Chen G, Murphy NP, Maidment NT, Ostlund SB. PMID: 30166974; PMCID: PMC6106797.
      View in: PubMed   Mentions: 9  
    11. Not worth the wait: cocaine alters reward processing in the nucleus accumbens. Neuropsychopharmacology. 2018 11; 43(12):2333-2334. Ostlund SB, Cui Y. PMID: 29844476; PMCID: PMC6180040.
      View in: PubMed   Mentions:    Fields:    
    12. Contributions of Pavlovian incentive motivation to cue-potentiated feeding. Sci Rep. 2018 02 09; 8(1):2766. Marshall AT, Halbout B, Liu AT, Ostlund SB. PMID: 29426846; PMCID: PMC5807356.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. Pattern of access determines influence of junk food diet on cue sensitivity and palatability. Appetite. 2018 04 01; 123:135-145. Kosheleff AR, Araki J, Hsueh J, Le A, Quizon K, Ostlund SB, Maidment NT, Murphy NP. PMID: 29248689; PMCID: PMC5817006.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    14. Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function. PLoS One. 2017; 12(10):e0185796. Mittal N, Minasyan A, Romaneschi N, Hakimian JK, Gonzalez-Fernandez G, Albert R, Desai N, Mendez IA, Schallert T, Ostlund SB, Walwyn W. PMID: 28973019; PMCID: PMC5626489.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Sex-specific enhancement of palatability-driven feeding in adolescent rats. PLoS One. 2017; 12(7):e0180907. Marshall AT, Liu AT, Murphy NP, Maidment NT, Ostlund SB. PMID: 28708901; PMCID: PMC5510835.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    16. Modulation of cue-triggered reward seeking by cholinergic signaling in the dorsomedial striatum. Eur J Neurosci. 2017 02; 45(3):358-364. Ostlund SB, Liu AT, Wassum KM, Maidment NT. PMID: 27813263; PMCID: PMC5293608.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    17. Nucleus Accumbens Acetylcholine Receptors Modulate Dopamine and Motivation. Neuropsychopharmacology. 2016 11; 41(12):2830-2838. Collins AL, Aitken TJ, Greenfield VY, Ostlund SB, Wassum KM. PMID: 27240658; PMCID: PMC5061892.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    18. A Closer Look at the Effects of Repeated Cocaine Exposure on Adaptive Decision-Making under Conditions That Promote Goal-Directed Control. Front Psychiatry. 2016; 7:44. Halbout B, Liu AT, Ostlund SB. PMID: 27047400; PMCID: PMC4800177.
      View in: PubMed   Mentions: 16  
    19. Involvement of Endogenous Enkephalins and β-Endorphin in Feeding and Diet-Induced Obesity. Neuropsychopharmacology. 2015 Aug; 40(9):2103-12. Mendez IA, Ostlund SB, Maidment NT, Murphy NP. PMID: 25754760; PMCID: PMC4613613.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    20. Inflated reward value in early opiate withdrawal. Addict Biol. 2016 Mar; 21(2):221-33. Wassum KM, Greenfield VY, Linker KE, Maidment NT, Ostlund SB. PMID: 25081350; PMCID: PMC4312551.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    21. Phasic mesolimbic dopamine signaling encodes the facilitation of incentive motivation produced by repeated cocaine exposure. Neuropsychopharmacology. 2014 Sep; 39(10):2441-9. Ostlund SB, LeBlanc KH, Kosheleff AR, Wassum KM, Maidment NT. PMID: 24804846; PMCID: PMC4138756.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    22. A kinder, gentler dopamine… highlighting dopamine's role in behavioral flexibility. Front Neurosci. 2014; 8:4. Beeler JA, Cools R, Luciana M, Ostlund SB, Petzinger G. PMID: 24478624; PMCID: PMC3901300.
      View in: PubMed   Mentions: 12  
    23. Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward. Nat Neurosci. 2014 Feb; 17(2):254-61. Cui Y, Ostlund SB, James AS, Park CS, Ge W, Roberts KW, Mittal N, Murphy NP, Cepeda C, Kieffer BL, Levine MS, Jentsch JD, Walwyn WM, Sun YE, Evans CJ, Maidment NT, Yang XW. PMID: 24413699; PMCID: PMC4008330.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    24. Differential effects of systemic cholinergic receptor blockade on Pavlovian incentive motivation and goal-directed action selection. Neuropsychopharmacology. 2014 May; 39(6):1490-7. Ostlund SB, Kosheleff AR, Maidment NT. PMID: 24370780; PMCID: PMC3988553.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    25. Impact of repeated intravenous cocaine administration on incentive motivation depends on mode of drug delivery. Addict Biol. 2014 Nov; 19(6):965-71. LeBlanc KH, Maidment NT, Ostlund SB. PMID: 23639056; PMCID: PMC3903657.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    26. Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats. PLoS One. 2013; 8(4):e61355. LeBlanc KH, Maidment NT, Ostlund SB. PMID: 23646106; PMCID: PMC3640016.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    27. Decreased consumption of sweet fluids in μ opioid receptor knockout mice: a microstructural analysis of licking behavior. Psychopharmacology (Berl). 2013 Sep; 229(1):105-13. Ostlund SB, Kosheleff A, Maidment NT, Murphy NP. PMID: 23568577; PMCID: PMC3742650.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    28. Phasic mesolimbic dopamine release tracks reward seeking during expression of Pavlovian-to-instrumental transfer. Biol Psychiatry. 2013 Apr 15; 73(8):747-55. Wassum KM, Ostlund SB, Loewinger GC, Maidment NT. PMID: 23374641; PMCID: PMC3615104.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    29. Pavlovian-to-instrumental transfer in cocaine seeking rats. Behav Neurosci. 2012 Oct; 126(5):681-9. LeBlanc KH, Ostlund SB, Maidment NT. PMID: 22866668; PMCID: PMC3496413.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    30. Relative response cost determines the sensitivity of instrumental reward seeking to dopamine receptor blockade. Neuropsychopharmacology. 2012 Nov; 37(12):2653-60. Ostlund SB, Kosheleff AR, Maidment NT. PMID: 22805602; PMCID: PMC3473331.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    31. Phasic mesolimbic dopamine signaling precedes and predicts performance of a self-initiated action sequence task. Biol Psychiatry. 2012 May 15; 71(10):846-54. Wassum KM, Ostlund SB, Maidment NT. PMID: 22305286; PMCID: PMC3471807.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    32. The orbitofrontal cortex, predicted value, and choice. Ann N Y Acad Sci. 2011 Dec; 1239:43-50. Balleine BW, Leung BK, Ostlund SB. PMID: 22145874.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    33. Dopamine receptor blockade attenuates the general incentive motivational effects of noncontingently delivered rewards and reward-paired cues without affecting their ability to bias action selection. Neuropsychopharmacology. 2012 Jan; 37(2):508-19. Ostlund SB, Maidment NT. PMID: 21918507; PMCID: PMC3242312.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    34. Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling. Learn Mem. 2011; 18(7):475-83. Wassum KM, Ostlund SB, Balleine BW, Maidment NT. PMID: 21693635; PMCID: PMC3125614.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    35. Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning. J Neurosci. 2011 Jan 05; 31(1):200-7. Ostlund SB, Wassum KM, Murphy NP, Balleine BW, Maidment NT. PMID: 21209205; PMCID: PMC3078720.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    36. Alcohol-Paired Contextual Cues Produce an Immediate and Selective Loss of Goal-directed Action in Rats. Front Integr Neurosci. 2010; 4. Ostlund SB, Maidment NT, Balleine BW. PMID: 20725634; PMCID: PMC2917216.
      View in: PubMed   Mentions: 27  
    37. Distinct opioid circuits determine the palatability and the desirability of rewarding events. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12512-7. Wassum KM, Ostlund SB, Maidment NT, Balleine BW. PMID: 19597155; PMCID: PMC2718390.
      View in: PubMed   Mentions: 79     Fields:    Translation:Animals
    38. Resolution of conflict between goal-directed actions: outcome encoding and neural control processes. J Exp Psychol Anim Behav Process. 2009 Jul; 35(3):382-93. de Wit S, Ostlund SB, Balleine BW, Dickinson A. PMID: 19594283.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    39. Evidence of action sequence chunking in goal-directed instrumental conditioning and its dependence on the dorsomedial prefrontal cortex. J Neurosci. 2009 Jun 24; 29(25):8280-7. Ostlund SB, Winterbauer NE, Balleine BW. PMID: 19553467; PMCID: PMC6666053.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    40. The integrative function of the basal ganglia in instrumental conditioning. Behav Brain Res. 2009 Apr 12; 199(1):43-52. Balleine BW, Liljeholm M, Ostlund SB. PMID: 19027797.
      View in: PubMed   Mentions: 169     Fields:    
    41. Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks. Eur J Neurosci. 2008 Oct; 28(8):1437-48. Yin HH, Ostlund SB, Balleine BW. PMID: 18793321; PMCID: PMC2756656.
      View in: PubMed   Mentions: 205     Fields:    Translation:HumansAnimals
    42. Differential involvement of the basolateral amygdala and mediodorsal thalamus in instrumental action selection. J Neurosci. 2008 Apr 23; 28(17):4398-405. Ostlund SB, Balleine BW. PMID: 18434518; PMCID: PMC2652225.
      View in: PubMed   Mentions: 93     Fields:    Translation:Animals
    43. On habits and addiction: An associative analysis of compulsive drug seeking. Drug Discov Today Dis Models. 2008; 5(4):235-245. Ostlund SB, Balleine BW. PMID: 20582332; PMCID: PMC2891067.
      View in: PubMed   Mentions: 64  
    44. Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6. Nat Neurosci. 2007 Nov; 10(11):1395-7. Lobo MK, Cui Y, Ostlund SB, Balleine BW, Yang XW. PMID: 17934457.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    45. The contribution of orbitofrontal cortex to action selection. Ann N Y Acad Sci. 2007 Dec; 1121:174-92. Ostlund SB, Balleine BW. PMID: 17872392.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    46. Orbitofrontal cortex mediates outcome encoding in Pavlovian but not instrumental conditioning. J Neurosci. 2007 May 02; 27(18):4819-25. Ostlund SB, Balleine BW. PMID: 17475789; PMCID: PMC6672090.
      View in: PubMed   Mentions: 199     Fields:    Translation:Animals
    47. The influence of Pavlovian cues on instrumental performance is mediated by CaMKII activity in the striatum. Eur J Neurosci. 2007 Apr; 25(8):2491-7. Wiltgen BJ, Law M, Ostlund S, Mayford M, Balleine BW. PMID: 17445244.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    48. Still at the choice-point: action selection and initiation in instrumental conditioning. Ann N Y Acad Sci. 2007 May; 1104:147-71. Balleine BW, Ostlund SB. PMID: 17360797.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    49. Selective reinstatement of instrumental performance depends on the discriminative stimulus properties of the mediating outcome. Learn Behav. 2007 Feb; 35(1):43-52. Ostlund SB, Balline BW. PMID: 17557390.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    50. Lesions of medial prefrontal cortex disrupt the acquisition but not the expression of goal-directed learning. J Neurosci. 2005 Aug 24; 25(34):7763-70. Ostlund SB, Balleine BW. PMID: 16120777; PMCID: PMC6725247.
      View in: PubMed   Mentions: 134     Fields:    Translation:Animals
    51. The role of the dorsomedial striatum in instrumental conditioning. Eur J Neurosci. 2005 Jul; 22(2):513-23. Yin HH, Ostlund SB, Knowlton BJ, Balleine BW. PMID: 16045504.
      View in: PubMed   Mentions: 486     Fields:    Translation:Animals
    52. Consolidation and reconsolidation of incentive learning in the amygdala. J Neurosci. 2005 Jan 26; 25(4):830-5. Wang SH, Ostlund SB, Nader K, Balleine BW. PMID: 15673662; PMCID: PMC6725620.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    53. Sensitivity to instrumental contingency degradation is mediated by the entorhinal cortex and its efferents via the dorsal hippocampus. J Neurosci. 2002 Dec 15; 22(24):10976-84. Corbit LH, Ostlund SB, Balleine BW. PMID: 12486193; PMCID: PMC6758438.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
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