Ostlund, Sean B

TitleAssistant Professor
InstitutionUniversity of California, Irvine
DepartmentAnesthesiology and Perioperative Care
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-1347
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    Collapse Research 
    Collapse Research Activities and Funding
    Cholinergic regulation of striatal neurochemistry in cue-triggered decision-making
    NIH/NIMH R01MH106972Apr 15, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Neurochemical bases for changes in decision-making across the lifespan
    NIH/NIA R01AG045380Aug 1, 2014 - May 31, 2019
    Role: Co-Principal Investigator
    Cafeteria diet-induced dysregulation of food seeking: neurochemical bases
    NIH/NIDDK R01DK098709May 1, 2014 - Apr 30, 2017
    Role: Co-Principal Investigator
    Cocaine-Seeking and the Transfer of Behavioral Control
    NIH/NIDA R01DA029035Feb 1, 2011 - Nov 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Marshall AT, Ostlund SB. Repeated cocaine exposure dysregulates cognitive control over cue-evoked reward-seeking behavior during Pavlovian-to-instrumental transfer. Learn Mem. 2018 Sep; 25(9):399-409. PMID: 30115761.
      View in: PubMed
    2. Kosheleff AR, Araki J, Tsan L, Chen G, Murphy NP, Maidment NT, Ostlund SB. Junk Food Exposure Disrupts Selection of Food-Seeking Actions in Rats. Front Psychiatry. 2018; 9:350. PMID: 30166974.
      View in: PubMed
    3. Ostlund SB, Cui Y. Not worth the wait: cocaine alters reward processing in the nucleus accumbens. Neuropsychopharmacology. 2018 May 29. PMID: 29844476.
      View in: PubMed
    4. Marshall AT, Halbout B, Liu AT, Ostlund SB. Contributions of Pavlovian incentive motivation to cue-potentiated feeding. Sci Rep. 2018 Feb 09; 8(1):2766. PMID: 29426846.
      View in: PubMed
    5. Kosheleff AR, Araki J, Hsueh J, Le A, Quizon K, Ostlund SB, Maidment NT, Murphy NP. Pattern of access determines influence of junk food diet on cue sensitivity and palatability. Appetite. 2018 04 01; 123:135-145. PMID: 29248689.
      View in: PubMed
    6. Mittal N, Minasyan A, Romaneschi N, Hakimian JK, Gonzalez-Fernandez G, Albert R, Desai N, Mendez IA, Schallert T, Ostlund SB, Walwyn W. Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function. PLoS One. 2017; 12(10):e0185796. PMID: 28973019.
      View in: PubMed
    7. Marshall AT, Liu AT, Murphy NP, Maidment NT, Ostlund SB. Sex-specific enhancement of palatability-driven feeding in adolescent rats. PLoS One. 2017; 12(7):e0180907. PMID: 28708901.
      View in: PubMed
    8. Ostlund SB, Liu AT, Wassum KM, Maidment NT. Modulation of cue-triggered reward seeking by cholinergic signaling in the dorsomedial striatum. Eur J Neurosci. 2017 Feb; 45(3):358-364. PMID: 27813263.
      View in: PubMed
    9. Collins AL, Aitken TJ, Greenfield VY, Ostlund SB, Wassum KM. Nucleus Accumbens Acetylcholine Receptors Modulate Dopamine and Motivation. Neuropsychopharmacology. 2016 11; 41(12):2830-2838. PMID: 27240658.
      View in: PubMed
    10. Halbout B, Liu AT, Ostlund SB. A Closer Look at the Effects of Repeated Cocaine Exposure on Adaptive Decision-Making under Conditions That Promote Goal-Directed Control. Front Psychiatry. 2016; 7:44. PMID: 27047400; PMCID: PMC4800177.
    11. Mendez IA, Ostlund SB, Maidment NT, Murphy NP. Involvement of Endogenous Enkephalins and ß-Endorphin in Feeding and Diet-Induced Obesity. Neuropsychopharmacology. 2015 Aug; 40(9):2103-12. PMID: 25754760; PMCID: PMC4613613.
    12. Wassum KM, Greenfield VY, Linker KE, Maidment NT, Ostlund SB. Inflated reward value in early opiate withdrawal. Addict Biol. 2016 Mar; 21(2):221-33. PMID: 25081350; PMCID: PMC4312551.
    13. Ostlund SB, LeBlanc KH, Kosheleff AR, Wassum KM, Maidment NT. Phasic mesolimbic dopamine signaling encodes the facilitation of incentive motivation produced by repeated cocaine exposure. Neuropsychopharmacology. 2014 Sep; 39(10):2441-9. PMID: 24804846; PMCID: PMC4138756.
    14. Beeler JA, Cools R, Luciana M, Ostlund SB, Petzinger G. A kinder, gentler dopamine… highlighting dopamine's role in behavioral flexibility. Front Neurosci. 2014; 8:4. PMID: 24478624; PMCID: PMC3901300.
    15. Cui Y, Ostlund SB, James AS, Park CS, Ge W, Roberts KW, Mittal N, Murphy NP, Cepeda C, Kieffer BL, Levine MS, Jentsch JD, Walwyn WM, Sun YE, Evans CJ, Maidment NT, Yang XW. Targeted expression of µ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward. Nat Neurosci. 2014 Feb; 17(2):254-61. PMID: 24413699; PMCID: PMC4008330.
    16. Ostlund SB, Kosheleff AR, Maidment NT. Differential effects of systemic cholinergic receptor blockade on Pavlovian incentive motivation and goal-directed action selection. Neuropsychopharmacology. 2014 May; 39(6):1490-7. PMID: 24370780; PMCID: PMC3988553.
    17. LeBlanc KH, Maidment NT, Ostlund SB. Impact of repeated intravenous cocaine administration on incentive motivation depends on mode of drug delivery. Addict Biol. 2014 Nov; 19(6):965-71. PMID: 23639056; PMCID: PMC3903657.
    18. LeBlanc KH, Maidment NT, Ostlund SB. Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats. PLoS One. 2013; 8(4):e61355. PMID: 23646106; PMCID: PMC3640016.
    19. Ostlund SB, Kosheleff A, Maidment NT, Murphy NP. Decreased consumption of sweet fluids in µ opioid receptor knockout mice: a microstructural analysis of licking behavior. Psychopharmacology (Berl). 2013 Sep; 229(1):105-13. PMID: 23568577; PMCID: PMC3742650.
    20. Wassum KM, Ostlund SB, Loewinger GC, Maidment NT. Phasic mesolimbic dopamine release tracks reward seeking during expression of Pavlovian-to-instrumental transfer. Biol Psychiatry. 2013 Apr 15; 73(8):747-55. PMID: 23374641; PMCID: PMC3615104.
    21. LeBlanc KH, Ostlund SB, Maidment NT. Pavlovian-to-instrumental transfer in cocaine seeking rats. Behav Neurosci. 2012 Oct; 126(5):681-9. PMID: 22866668; PMCID: PMC3496413.
    22. Ostlund SB, Kosheleff AR, Maidment NT. Relative response cost determines the sensitivity of instrumental reward seeking to dopamine receptor blockade. Neuropsychopharmacology. 2012 Nov; 37(12):2653-60. PMID: 22805602; PMCID: PMC3473331.
    23. Wassum KM, Ostlund SB, Maidment NT. Phasic mesolimbic dopamine signaling precedes and predicts performance of a self-initiated action sequence task. Biol Psychiatry. 2012 May 15; 71(10):846-54. PMID: 22305286; PMCID: PMC3471807.
    24. Balleine BW, Leung BK, Ostlund SB. The orbitofrontal cortex, predicted value, and choice. Ann N Y Acad Sci. 2011 Dec; 1239:43-50. PMID: 22145874.
      View in: PubMed
    25. Ostlund SB, Maidment NT. Dopamine receptor blockade attenuates the general incentive motivational effects of noncontingently delivered rewards and reward-paired cues without affecting their ability to bias action selection. Neuropsychopharmacology. 2012 Jan; 37(2):508-19. PMID: 21918507; PMCID: PMC3242312.
    26. Wassum KM, Ostlund SB, Balleine BW, Maidment NT. Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling. Learn Mem. 2011; 18(7):475-83. PMID: 21693635; PMCID: PMC3125614.
    27. Ostlund SB, Wassum KM, Murphy NP, Balleine BW, Maidment NT. Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning. J Neurosci. 2011 Jan 05; 31(1):200-7. PMID: 21209205; PMCID: PMC3078720.
    28. Ostlund SB, Maidment NT, Balleine BW. Alcohol-Paired Contextual Cues Produce an Immediate and Selective Loss of Goal-directed Action in Rats. Front Integr Neurosci. 2010; 4. PMID: 20725634; PMCID: PMC2917216.
    29. de Wit S, Ostlund SB, Balleine BW, Dickinson A. Resolution of conflict between goal-directed actions: outcome encoding and neural control processes. J Exp Psychol Anim Behav Process. 2009 Jul; 35(3):382-93. PMID: 19594283.
      View in: PubMed
    30. Ostlund SB, Winterbauer NE, Balleine BW. Evidence of action sequence chunking in goal-directed instrumental conditioning and its dependence on the dorsomedial prefrontal cortex. J Neurosci. 2009 Jun 24; 29(25):8280-7. PMID: 19553467.
      View in: PubMed
    31. Balleine BW, Liljeholm M, Ostlund SB. The integrative function of the basal ganglia in instrumental conditioning. Behav Brain Res. 2009 Apr 12; 199(1):43-52. PMID: 19027797.
      View in: PubMed
    32. Yin HH, Ostlund SB, Balleine BW. Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks. Eur J Neurosci. 2008 Oct; 28(8):1437-48. PMID: 18793321; PMCID: PMC2756656.
    33. Ostlund SB, Balleine BW. Differential involvement of the basolateral amygdala and mediodorsal thalamus in instrumental action selection. J Neurosci. 2008 Apr 23; 28(17):4398-405. PMID: 18434518; PMCID: PMC2652225.
    34. Ostlund SB, Balleine BW. On habits and addiction: An associative analysis of compulsive drug seeking. Drug Discov Today Dis Models. 2008; 5(4):235-245. PMID: 20582332.
      View in: PubMed
    35. Lobo MK, Cui Y, Ostlund SB, Balleine BW, Yang XW. Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6. Nat Neurosci. 2007 Nov; 10(11):1395-7. PMID: 17934457.
      View in: PubMed
    36. Ostlund SB, Balleine BW. The contribution of orbitofrontal cortex to action selection. Ann N Y Acad Sci. 2007 Dec; 1121:174-92. PMID: 17872392.
      View in: PubMed
    37. Ostlund SB, Balleine BW. Orbitofrontal cortex mediates outcome encoding in Pavlovian but not instrumental conditioning. J Neurosci. 2007 May 02; 27(18):4819-25. PMID: 17475789.
      View in: PubMed
    38. Wiltgen BJ, Law M, Ostlund S, Mayford M, Balleine BW. The influence of Pavlovian cues on instrumental performance is mediated by CaMKII activity in the striatum. Eur J Neurosci. 2007 Apr; 25(8):2491-7. PMID: 17445244.
      View in: PubMed
    39. Balleine BW, Ostlund SB. Still at the choice-point: action selection and initiation in instrumental conditioning. Ann N Y Acad Sci. 2007 May; 1104:147-71. PMID: 17360797.
      View in: PubMed
    40. Ostlund SB, Balline BW. Selective reinstatement of instrumental performance depends on the discriminative stimulus properties of the mediating outcome. Learn Behav. 2007 Feb; 35(1):43-52. PMID: 17557390.
      View in: PubMed
    41. Ostlund SB, Balleine BW. Lesions of medial prefrontal cortex disrupt the acquisition but not the expression of goal-directed learning. J Neurosci. 2005 Aug 24; 25(34):7763-70. PMID: 16120777.
      View in: PubMed
    42. Yin HH, Ostlund SB, Knowlton BJ, Balleine BW. The role of the dorsomedial striatum in instrumental conditioning. Eur J Neurosci. 2005 Jul; 22(2):513-23. PMID: 16045504.
      View in: PubMed
    43. Wang SH, Ostlund SB, Nader K, Balleine BW. Consolidation and reconsolidation of incentive learning in the amygdala. J Neurosci. 2005 Jan 26; 25(4):830-5. PMID: 15673662.
      View in: PubMed
    44. Corbit LH, Ostlund SB, Balleine BW. Sensitivity to instrumental contingency degradation is mediated by the entorhinal cortex and its efferents via the dorsal hippocampus. J Neurosci. 2002 Dec 15; 22(24):10976-84. PMID: 12486193.
      View in: PubMed
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