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Frostig, Ron

Title(s)Professor, Neurobiology & Behavior
Phone(949) 824-2883, 5031
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    Collapse Research 
    Collapse Research Activities and Funding
    Neurovascular Plasticity
    NIH/NINDS R01NS066001Aug 15, 2010 - Jul 31, 2015
    Role: Principal Investigator
    The Size of a Cortical Representation
    NIH/NINDS R01NS055832Dec 15, 2007 - Nov 30, 2013
    Role: Principal Investigator
    Experience Dependent Plasticity of The Developing Cortex
    NIH/NINDS R01NS048350Sep 15, 2004 - Nov 30, 2009
    Role: Principal Investigator
    Behaviorally Induced Cortical Plasticity
    NIH/NINDS R01NS043165Jul 1, 2003 - Jun 30, 2008
    Role: Principal Investigator
    MECHANISM UNDERLYING NGF-INDUCED CORTICAL PLASTICITY
    NIH/NINDS R01NS039760Jan 1, 2000 - Dec 31, 2004
    Role: Principal Investigator
    SENSORY MODIFICATION OF CORTICAL ORGANIZATION
    NIH/NINDS R01NS034519Aug 19, 1996 - Jun 30, 2001
    Role: Principal Investigator
    FUNCTIONAL CORRELATES OF LEARNING IN THE CEREBRAL CORTEX
    NIH/NIMH R03MH050362Apr 1, 1993 - Mar 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hancock AM, Frostig RD. Hypertension prevents a sensory stimulation-based collateral therapeutic from protecting the cortex from impending ischemic stroke damage in a spontaneously hypersensitive rat model. PLoS One. 2018; 13(10):e0206291. PMID: 30352082.
      View in: PubMed
    2. Johnson BA, Frostig RD. Long-Range, Border-Crossing, Horizontal Axon Radiations Are a Common Feature of Rat Neocortical Regions That Differ in Cytoarchitecture. Front Neuroanat. 2018; 12:50. PMID: 29977194.
      View in: PubMed
    3. Frostig RD, Petersen CCH. Special Section Guest Editorial: Pioneers in Neurophotonics: Special Section Honoring Professor Amiram Grinvald. Neurophotonics. 2017 Jul; 4(3):031200. PMID: 28948189.
      View in: PubMed
    4. Hancock AM, Frostig RD. Testing the effects of sensory stimulation as a collateral-based therapeutic for ischemic stroke in C57BL/6J and CD1 mouse strains. PLoS One. 2017; 12(9):e0183909. PMID: 28902897.
      View in: PubMed
    5. Frostig RD, Chen-Bee CH, Johnson BA, Jacobs NS. Imaging Cajal's neuronal avalanche: how wide-field optical imaging of the point-spread advanced the understanding of neocortical structure-function relationship. Neurophotonics. 2017 Jul; 4(3):031217. PMID: 28630879.
      View in: PubMed
    6. Jacobs NS, Frostig RD. Prominent lateral spread of imaged evoked activity beyond cortical columns in barrel cortex provides foundation for coding whisker identity. Neurophotonics. 2017 Jul; 4(3):031218. PMID: 28630880.
      View in: PubMed
    7. Qi L, Zhu J, Hancock AM, Dai C, Zhang X, Frostig RD, Chen Z. Fully distributed absolute blood flow velocity measurement for middle cerebral arteries using Doppler optical coherence tomography. Biomed Opt Express. 2016 Feb 01; 7(2):601-15. PMID: 26977365.
      View in: PubMed
    8. Konecky SD, Wilson RH, Hagen N, Mazhar A, Tkaczyk TS, Frostig RD, Tromberg BJ. Hyperspectral optical tomography of intrinsic signals in the rat cortex. Neurophotonics. 2015 Oct; 2(4):045003. PMID: 26835483.
      View in: PubMed
    9. Johnson BA, Frostig RD. Long, intrinsic horizontal axons radiating through and beyond rat barrel cortex have spatial distributions similar to horizontal spreads of activity evoked by whisker stimulation. Brain Struct Funct. 2016 09; 221(7):3617-39. PMID: 26438334.
      View in: PubMed
    10. Jacobs NS, Chen-Bee CH, Frostig RD. Emergence of spatiotemporal invariance in large neuronal ensembles in rat barrel cortex. Front Neural Circuits. 2015; 9:34. PMID: 26217194.
      View in: PubMed
    11. Johnson BA, Frostig RD. Photonics meets connectomics: case of diffuse, long-range horizontal projections in rat cortex. Neurophotonics. 2015 Oct; 2(4):041403. PMID: 26158017.
      View in: PubMed
    12. Stehberg J, Dang PT, Frostig RD. Unimodal primary sensory cortices are directly connected by long-range horizontal projections in the rat sensory cortex. Front Neuroanat. 2014; 8:93. PMID: 25309339.
      View in: PubMed
    13. Lay CC, Frostig RD. Complete protection from impending stroke following permanent middle cerebral artery occlusion in awake, behaving rats. Eur J Neurosci. 2014 Nov; 40(9):3413-21. PMID: 25216240.
      View in: PubMed
    14. Hancock AM, Lay CC, Davis MF, Frostig RD. Sensory Stimulation-Based Complete Protection from Ischemic Stroke Remains Stable at 4 Months Post-Occlusion of MCA. J Neurol Disord. 2013 Nov; 1(4):135. PMID: 24634892.
      View in: PubMed
    15. Davis MF, Lay C, Frostig RD. Permanent cerebral vessel occlusion via double ligature and transection. J Vis Exp. 2013 Jul 21; (77). PMID: 23912746.
      View in: PubMed
    16. Lay CC, Jacobs N, Hancock AM, Zhou Y, Frostig RD. Early stimulation treatment provides complete sensory-induced protection from ischemic stroke under isoflurane anesthesia. Eur J Neurosci. 2013 Aug; 38(3):2445-52. PMID: 23586641.
      View in: PubMed
    17. Chen-Bee CH, Zhou Y, Jacobs NS, Lim B, Frostig RD. Whisker array functional representation in rat barrel cortex: transcendence of one-to-one topography and its underlying mechanism. Front Neural Circuits. 2012; 6:93. PMID: 23205005.
      View in: PubMed
    18. Frostig RD, Lay CC, Davis MF. A rat's whiskers point the way toward a novel stimulus-dependent, protective stroke therapy. Neuroscientist. 2013 Jun; 19(3):313-28. PMID: 23047156.
      View in: PubMed
    19. Lay CC, Davis MF, Chen-Bee CH, Frostig RD. Mild sensory stimulation protects the aged rodent from cortical ischemic stroke after permanent middle cerebral artery occlusion. J Am Heart Assoc. 2012 Aug; 1(4):e001255. PMID: 23130160.
      View in: PubMed
    20. Lay CC, Davis MF, Chen-Bee CH, Frostig RD. Mild sensory stimulation reestablishes cortical function during the acute phase of ischemia. J Neurosci. 2011 Aug 10; 31(32):11495-504. PMID: 21832179.
      View in: PubMed
    21. Gomez-Pinilla F, Ying Z, Agoncillo T, Frostig R. The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: effects of whisker use. Brain Res. 2011 May 04; 1388:39-47. PMID: 21385568.
      View in: PubMed
    22. Davis MF, Lay CC, Chen-Bee CH, Frostig RD. Amount but not pattern of protective sensory stimulation alters recovery after permanent middle cerebral artery occlusion. Stroke. 2011 Mar; 42(3):792-8. PMID: 21317269.
      View in: PubMed
    23. Lay CC, Davis MF, Chen-Bee CH, Frostig RD. Mild sensory stimulation completely protects the adult rodent cortex from ischemic stroke. PLoS One. 2010 Jun 23; 5(6):e11270. PMID: 20585659.
      View in: PubMed
    24. Chen-Bee CH, Agoncillo T, Lay CC, Frostig RD. Intrinsic signal optical imaging of brain function using short stimulus delivery intervals. J Neurosci Methods. 2010 Mar 30; 187(2):171-82. PMID: 20079373.
      View in: PubMed
    25. Abookasis D, Lay CC, Mathews MS, Linskey ME, Frostig RD, Tromberg BJ. Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination. J Biomed Opt. 2009 Mar-Apr; 14(2):024033. PMID: 19405762.
      View in: PubMed
    26. Frostig RD, Xiong Y, Chen-Bee CH, Kvasnák E, Stehberg J. Large-scale organization of rat sensorimotor cortex based on a motif of large activation spreads. J Neurosci. 2008 Dec 03; 28(49):13274-84. PMID: 19052219.
      View in: PubMed
    27. Chen-Bee CH, Agoncillo T, Xiong Y, Frostig RD. The triphasic intrinsic signal: implications for functional imaging. J Neurosci. 2007 Apr 25; 27(17):4572-86. PMID: 17460070.
      View in: PubMed
    28. Frostig RD. Functional organization and plasticity in the adult rat barrel cortex: moving out-of-the-box. Curr Opin Neurobiol. 2006 Aug; 16(4):445-50. PMID: 16822663.
      View in: PubMed
    29. Polley DB, Rickert JL, Frostig RD. Whisker-based discrimination of object orientation determined with a rapid training paradigm. Neurobiol Learn Mem. 2005 Mar; 83(2):134-42. PMID: 15721797.
      View in: PubMed
    30. Prakash N, Frostig RD. What has intrinsic signal optical imaging taught us about NGF-induced rapid plasticity in adult cortex and its relationship to the cholinergic system? Mol Imaging Biol. 2005 Jan-Feb; 7(1):14-21. PMID: 15912271.
      View in: PubMed
    31. Polley DB, Kvasnák E, Frostig RD. Naturalistic experience transforms sensory maps in the adult cortex of caged animals. Nature. 2004 May 06; 429(6987):67-71. PMID: 15129281.
      View in: PubMed
    32. Prakash N, Cohen-Cory S, Penschuck S, Frostig RD. Basal forebrain cholinergic system is involved in rapid nerve growth factor (NGF)-induced plasticity in the barrel cortex of adult rats. J Neurophysiol. 2004 Jan; 91(1):424-37. PMID: 14507983.
      View in: PubMed
    33. Penschuck S, Chen-Bee CH, Prakash N, Frostig RD. In vivo modulation of a cortical functional sensory representation shortly after topical cholinergic agent application. J Comp Neurol. 2002 Oct 07; 452(1):38-50. PMID: 12205708.
      View in: PubMed
    34. Brett-Green BA, Chen-Bee CH, Frostig RD. Comparing the functional representations of central and border whiskers in rat primary somatosensory cortex. J Neurosci. 2001 Dec 15; 21(24):9944-54. PMID: 11739601.
      View in: PubMed
    35. Prakash N, Vanderhaeghen P, Cohen-Cory S, Frisén J, Flanagan JG, Frostig RD. Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knock-out mice revealed by in vivo functional imaging. J Neurosci. 2000 Aug 01; 20(15):5841-7. PMID: 10908626.
      View in: PubMed
    36. Chen-Bee CH, Polley DB, Brett-Green B, Prakash N, Kwon MC, Frostig RD. Visualizing and quantifying evoked cortical activity assessed with intrinsic signal imaging. J Neurosci Methods. 2000 Apr 15; 97(2):157-73. PMID: 10788670.
      View in: PubMed
    37. Vanderhaeghen P, Lu Q, Prakash N, Frisén J, Walsh CA, Frostig RD, Flanagan JG. A mapping label required for normal scale of body representation in the cortex. Nat Neurosci. 2000 Apr; 3(4):358-65. PMID: 10725925.
      View in: PubMed
    38. Polley DB, Chen-Bee CH, Frostig RD. Two directions of plasticity in the sensory-deprived adult cortex. Neuron. 1999 Nov; 24(3):623-37. PMID: 10595514.
      View in: PubMed
    39. Polley DB, Chen-Bee CH, Frostig RD. Varying the degree of single-whisker stimulation differentially affects phases of intrinsic signals in rat barrel cortex. J Neurophysiol. 1999 Feb; 81(2):692-701. PMID: 10036270.
      View in: PubMed
    40. Chen-Bee CH, Kwon MC, Masino SA, Frostig RD. Areal extent quantification of functional representations using intrinsic signal optical imaging. J Neurosci Methods. 1996 Sep; 68(1):27-37. PMID: 8884610.
      View in: PubMed
    41. Chen-Bee CH, Frostig RD. Variability and interhemispheric asymmetry of single-whisker functional representations in rat barrel cortex. J Neurophysiol. 1996 Aug; 76(2):884-94. PMID: 8871206.
      View in: PubMed
    42. Prakash N, Cohen-Cory S, Frostig RD. RAPID and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo. Nature. 1996 Jun 20; 381(6584):702-6. PMID: 8649516.
      View in: PubMed
    43. Masino SA, Frostig RD. Quantitative long-term imaging of the functional representation of a whisker in rat barrel cortex. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4942-7. PMID: 8643508.
      View in: PubMed
    44. Bakin JS, Kwon MC, Masino SA, Weinberger NM, Frostig RD. Suprathreshold auditory cortex activation visualized by intrinsic signal optical imaging. Cereb Cortex. 1996 Mar-Apr; 6(2):120-30. PMID: 8670644.
      View in: PubMed
    45. Grinvald A, Lieke EE, Frostig RD, Hildesheim R. Cortical point-spread function and long-range lateral interactions revealed by real-time optical imaging of macaque monkey primary visual cortex. J Neurosci. 1994 May; 14(5 Pt 1):2545-68. PMID: 8182427.
      View in: PubMed
    46. Masino SA, Kwon MC, Dory Y, Frostig RD. Characterization of functional organization within rat barrel cortex using intrinsic signal optical imaging through a thinned skull. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):9998-10002. PMID: 8234348.
      View in: PubMed
    47. Grinvald A, Frostig RD, Siegel RM, Bartfeld E. High-resolution optical imaging of functional brain architecture in the awake monkey. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11559-63. PMID: 1763070.
      View in: PubMed
    48. Frostig RD, Lieke EE, Ts'o DY, Grinvald A. Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6082-6. PMID: 2117272.
      View in: PubMed
    49. Ts'o DY, Frostig RD, Lieke EE, Grinvald A. Functional organization of primate visual cortex revealed by high resolution optical imaging. Science. 1990 Jul 27; 249(4967):417-20. PMID: 2165630.
      View in: PubMed
    50. Frostig RD, Frostig Z, Harper RM. Recurring discharge patterns in multiple spike trains. I. Detection. Biol Cybern. 1990; 62(6):487-93. PMID: 2357472.
      View in: PubMed
    51. Lieke EE, Frostig RD, Arieli A, Ts'o DY, Hildesheim R, Grinvald A. Optical imaging of cortical activity: real-time imaging using extrinsic dye-signals and high resolution imaging based on slow intrinsic-signals. Annu Rev Physiol. 1989; 51:543-59. PMID: 2653196.
      View in: PubMed
    52. Grinvald A, Frostig RD, Lieke E, Hildesheim R. Optical imaging of neuronal activity. Physiol Rev. 1988 Oct; 68(4):1285-366. PMID: 3054949.
      View in: PubMed
    53. Frostig Z, Frostig RD. Analysis of frequency components in time series data. J Neurosci Methods. 1987 Nov; 22(1):79-87. PMID: 3695571.
      View in: PubMed
    54. Grinvald A, Lieke E, Frostig RD, Gilbert CD, Wiesel TN. Functional architecture of cortex revealed by optical imaging of intrinsic signals. Nature. 1986 Nov 27-Dec 3; 324(6095):361-4. PMID: 3785405.
      View in: PubMed
    55. Frostig RD, Frostig Z, Harper RM. Information trains. The technique and its uses in spike train and network analysis, with examples taken from the nucleus parabrachialis medialis during sleep-waking states. Brain Res. 1984 Nov 19; 322(1):67-74. PMID: 6518375.
      View in: PubMed
    56. Frostig RD, Gottlieb Y, Vaadia E, Abeles M. The effects of stimuli on the activity and functional connectivity of local neuronal groups in the cat auditory cortex. Brain Res. 1983 Aug 08; 272(2):211-21. PMID: 6616200.
      View in: PubMed