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The role of spontaneous and evoked neuronal activity in protection from impending stroke in rat model of permanent middle cerebral artery occlusion during the hyperacute state. Res Sq. 2025 May 06.
Malone HC, Bhatti MS, Frostig RD. PMID: 40386424; PMCID: PMC12083695.
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Astrocyte-neuron lactate shuttle plays a pivotal role in sensory-based neuroprotection in a rat model of permanent middle cerebral artery occlusion. Sci Rep. 2023 08 07; 13(1):12799.
Bhatti MS, Frostig RD. PMID: 37550353; PMCID: PMC10406860.
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6 Fields:
Translation:
AnimalsCells
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Astrocyte-neuron lactate shuttle plays a pivotal role in sensory-based neuroprotection in a rat model of permanent middle cerebral artery occlusion. Res Sq. 2023 Mar 30.
Bhatti M, Frostig RD. PMID: 37034797; PMCID: PMC10081351.
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Development of highly sensitive, flexible dual L-glutamate and GABA microsensors for in vivo brain sensing. Biosens Bioelectron. 2023 Feb 15; 222:114941.
Chu SS, Nguyen HA, Lin D, Bhatti M, Jones-Tinsley CE, Do AH, Frostig RD, Nenadic Z, Xu X, Lim MM, Cao H. PMID: 36455372.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Head Implants for the Neuroimaging of Awake, Head-Fixed Rats. J Vis Exp. 2022 09 07; (187).
Bhatti M, Malone H, Hui G, Frostig RD. PMID: 36155970.
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Animals
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Sensory stimulation-based protection from impending stroke following MCA occlusion is correlated with desynchronization of widespread spontaneous local field potentials. Sci Rep. 2022 02 02; 12(1):1744.
Rasheed W, Wodeyar A, Srinivasan R, Frostig RD. PMID: 35110588; PMCID: PMC8810838.
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3 Fields:
Translation:
Animals
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Author Correction: Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia. Sci Rep. 2021 Mar 24; 11(1):7173.
Wann EG, Wodeyar A, Srinivasan R, Frostig RD. PMID: 33762683; PMCID: PMC7991436.
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Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia. Sci Rep. 2020 12 08; 10(1):21441.
Wann EG, Wodeyar A, Srinivasan R, Frostig RD. PMID: 33293620; PMCID: PMC7722868.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Modeling Spectral Properties in Stationary Processes of Varying Dimensions with Applications to Brain Local Field Potential Signals. Entropy (Basel). 2020 Dec 05; 22(12).
Sundararajan RR, Frostig R, Ombao H. PMID: 33279920; PMCID: PMC7762144.
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PubMed Mentions:
1
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Regularized matrix data clustering and its application to image analysis. Biometrics. 2021 09; 77(3):890-902.
Gao X, Shen W, Zhang L, Hu J, Fortin NJ, Frostig RD, Ombao H. PMID: 32799339; PMCID: PMC7884484.
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PubMed Mentions:
8 Fields:
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Spatiotemporal dynamics of pial collateral blood flow following permanent middle cerebral artery occlusion in a rat model of sensory-based protection: a Doppler optical coherence tomography study. Neurophotonics. 2019 Oct; 6(4):045012.
Zhu J, Hancock AM, Qi L, Telkmann K, Shahbaba B, Chen Z, Frostig RD. PMID: 31824979; PMCID: PMC6903432.
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8
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Hypertension prevents a sensory stimulation-based collateral therapeutic from protecting the cortex from impending ischemic stroke damage in a spontaneously hypersensitive rat model. PLoS One. 2018; 13(10):e0206291.
Hancock AM, Frostig RD. PMID: 30352082; PMCID: PMC6198990.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Long-Range, Border-Crossing, Horizontal Axon Radiations Are a Common Feature of Rat Neocortical Regions That Differ in Cytoarchitecture. Front Neuroanat. 2018; 12:50.
Johnson BA, Frostig RD. PMID: 29977194; PMCID: PMC6021490.
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3
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Special Section Guest Editorial: Pioneers in Neurophotonics: Special Section Honoring Professor Amiram Grinvald. Neurophotonics. 2017 Jul; 4(3):031200.
Frostig RD, Petersen CCH. PMID: 28948189; PMCID: PMC5609496.
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Testing the effects of sensory stimulation as a collateral-based therapeutic for ischemic stroke in C57BL/6J and CD1 mouse strains. PLoS One. 2017; 12(9):e0183909.
Hancock AM, Frostig RD. PMID: 28902897; PMCID: PMC5597132.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Imaging Cajal's neuronal avalanche: how wide-field optical imaging of the point-spread advanced the understanding of neocortical structure-function relationship. Neurophotonics. 2017 Jul; 4(3):031217.
Frostig RD, Chen-Bee CH, Johnson BA, Jacobs NS. PMID: 28630879; PMCID: PMC5467767.
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PubMed Mentions:
8
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Prominent lateral spread of imaged evoked activity beyond cortical columns in barrel cortex provides foundation for coding whisker identity. Neurophotonics. 2017 Jul; 4(3):031218.
Jacobs NS, Frostig RD. PMID: 28630880; PMCID: PMC5464443.
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4
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Fully distributed absolute blood flow velocity measurement for middle cerebral arteries using Doppler optical coherence tomography. Biomed Opt Express. 2016 Feb 01; 7(2):601-15.
Qi L, Zhu J, Hancock AM, Dai C, Zhang X, Frostig RD, Chen Z. PMID: 26977365; PMCID: PMC4771474.
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PubMed Mentions:
13
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Hyperspectral optical tomography of intrinsic signals in the rat cortex. Neurophotonics. 2015 Oct; 2(4):045003.
Konecky SD, Wilson RH, Hagen N, Mazhar A, Tkaczyk TS, Frostig RD, Tromberg BJ. PMID: 26835483; PMCID: PMC4718192.
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PubMed Mentions:
9
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Long, intrinsic horizontal axons radiating through and beyond rat barrel cortex have spatial distributions similar to horizontal spreads of activity evoked by whisker stimulation. Brain Struct Funct. 2016 09; 221(7):3617-39.
Johnson BA, Frostig RD. PMID: 26438334; PMCID: PMC4821813.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Emergence of spatiotemporal invariance in large neuronal ensembles in rat barrel cortex. Front Neural Circuits. 2015; 9:34.
Jacobs NS, Chen-Bee CH, Frostig RD. PMID: 26217194; PMCID: PMC4495341.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Photonics meets connectomics: case of diffuse, long-range horizontal projections in rat cortex. Neurophotonics. 2015 Oct; 2(4):041403.
Johnson BA, Frostig RD. PMID: 26158017; PMCID: PMC4478784.
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PubMed Mentions:
5
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Unimodal primary sensory cortices are directly connected by long-range horizontal projections in the rat sensory cortex. Front Neuroanat. 2014; 8:93.
Stehberg J, Dang PT, Frostig RD. PMID: 25309339; PMCID: PMC4174042.
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PubMed Mentions:
40
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Complete protection from impending stroke following permanent middle cerebral artery occlusion in awake, behaving rats. Eur J Neurosci. 2014 Nov; 40(9):3413-21.
Lay CC, Frostig RD. PMID: 25216240; PMCID: PMC4218886.
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16 Translation:
Animals
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Sensory Stimulation-Based Complete Protection from Ischemic Stroke Remains Stable at 4 Months Post-Occlusion of MCA. J Neurol Disord. 2013 Nov; 1(4):135.
Hancock AM, Lay CC, Davis MF, Frostig RD. PMID: 24634892; PMCID: PMC3952275.
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8
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Permanent cerebral vessel occlusion via double ligature and transection. J Vis Exp. 2013 Jul 21; (77).
Davis MF, Lay C, Frostig RD. PMID: 23912746; PMCID: PMC3845834.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Early stimulation treatment provides complete sensory-induced protection from ischemic stroke under isoflurane anesthesia. Eur J Neurosci. 2013 Aug; 38(3):2445-52.
Lay CC, Jacobs N, Hancock AM, Zhou Y, Frostig RD. PMID: 23586641; PMCID: PMC3735829.
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PubMed Mentions:
14 Translation:
Animals
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Whisker array functional representation in rat barrel cortex: transcendence of one-to-one topography and its underlying mechanism. Front Neural Circuits. 2012; 6:93.
Chen-Bee CH, Zhou Y, Jacobs NS, Lim B, Frostig RD. PMID: 23205005; PMCID: PMC3506988.
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21 Fields:
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A rat's whiskers point the way toward a novel stimulus-dependent, protective stroke therapy. Neuroscientist. 2013 Jun; 19(3):313-28.
Frostig RD, Lay CC, Davis MF. PMID: 23047156; PMCID: PMC3710106.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimals
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Mild sensory stimulation protects the aged rodent from cortical ischemic stroke after permanent middle cerebral artery occlusion. J Am Heart Assoc. 2012 Aug; 1(4):e001255.
Lay CC, Davis MF, Chen-Bee CH, Frostig RD. PMID: 23130160; PMCID: PMC3487352.
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PubMed Mentions:
14 Fields:
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Mild sensory stimulation reestablishes cortical function during the acute phase of ischemia. J Neurosci. 2011 Aug 10; 31(32):11495-504.
Lay CC, Davis MF, Chen-Bee CH, Frostig RD. PMID: 21832179; PMCID: PMC3162364.
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PubMed Mentions:
26 Fields:
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The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: effects of whisker use. Brain Res. 2011 May 04; 1388:39-47.
Gomez-Pinilla F, Ying Z, Agoncillo T, Frostig R. PMID: 21385568; PMCID: PMC3225184.
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PubMed Mentions:
10 Fields:
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Amount but not pattern of protective sensory stimulation alters recovery after permanent middle cerebral artery occlusion. Stroke. 2011 Mar; 42(3):792-8.
Davis MF, Lay CC, Chen-Bee CH, Frostig RD. PMID: 21317269; PMCID: PMC3141731.
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PubMed Mentions:
15 Fields:
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Mild sensory stimulation completely protects the adult rodent cortex from ischemic stroke. PLoS One. 2010 Jun 23; 5(6):e11270.
Lay CC, Davis MF, Chen-Bee CH, Frostig RD. PMID: 20585659; PMCID: PMC2890583.
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PubMed Mentions:
38 Fields:
Translation:
Animals
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Intrinsic signal optical imaging of brain function using short stimulus delivery intervals. J Neurosci Methods. 2010 Mar 30; 187(2):171-82.
Chen-Bee CH, Agoncillo T, Lay CC, Frostig RD. PMID: 20079373; PMCID: PMC2832718.
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PubMed Mentions:
12 Fields:
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Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination. J Biomed Opt. 2009 Mar-Apr; 14(2):024033.
Abookasis D, Lay CC, Mathews MS, Linskey ME, Frostig RD, Tromberg BJ. PMID: 19405762; PMCID: PMC2868516.
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32 Fields:
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Large-scale organization of rat sensorimotor cortex based on a motif of large activation spreads. J Neurosci. 2008 Dec 03; 28(49):13274-84.
Frostig RD, Xiong Y, Chen-Bee CH, Kvasnák E, Stehberg J. PMID: 19052219; PMCID: PMC2710304.
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PubMed Mentions:
51 Fields:
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The triphasic intrinsic signal: implications for functional imaging. J Neurosci. 2007 Apr 25; 27(17):4572-86.
Chen-Bee CH, Agoncillo T, Xiong Y, Frostig RD. PMID: 17460070; PMCID: PMC6673004.
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PubMed Mentions:
44 Fields:
Translation:
Animals
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Functional organization and plasticity in the adult rat barrel cortex: moving out-of-the-box. Curr Opin Neurobiol. 2006 Aug; 16(4):445-50.
Frostig RD. PMID: 16822663.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Whisker-based discrimination of object orientation determined with a rapid training paradigm. Neurobiol Learn Mem. 2005 Mar; 83(2):134-42.
Polley DB, Rickert JL, Frostig RD. PMID: 15721797.
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PubMed Mentions:
22 Fields:
Translation:
Animals
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What has intrinsic signal optical imaging taught us about NGF-induced rapid plasticity in adult cortex and its relationship to the cholinergic system? Mol Imaging Biol. 2005 Jan-Feb; 7(1):14-21.
Prakash N, Frostig RD. PMID: 15912271.
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HumansAnimalsCells
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Naturalistic experience transforms sensory maps in the adult cortex of caged animals. Nature. 2004 May 06; 429(6987):67-71.
Polley DB, Kvasnák E, Frostig RD. PMID: 15129281.
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PubMed Mentions:
55 Fields:
Translation:
Animals
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Basal forebrain cholinergic system is involved in rapid nerve growth factor (NGF)-induced plasticity in the barrel cortex of adult rats. J Neurophysiol. 2004 Jan; 91(1):424-37.
Prakash N, Cohen-Cory S, Penschuck S, Frostig RD. PMID: 14507983.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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In vivo modulation of a cortical functional sensory representation shortly after topical cholinergic agent application. J Comp Neurol. 2002 Oct 07; 452(1):38-50.
Penschuck S, Chen-Bee CH, Prakash N, Frostig RD. PMID: 12205708.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Comparing the functional representations of central and border whiskers in rat primary somatosensory cortex. J Neurosci. 2001 Dec 15; 21(24):9944-54.
Brett-Green BA, Chen-Bee CH, Frostig RD. PMID: 11739601; PMCID: PMC6763036.
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PubMed Mentions:
22 Fields:
Translation:
Animals
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Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knock-out mice revealed by in vivo functional imaging. J Neurosci. 2000 Aug 01; 20(15):5841-7.
Prakash N, Vanderhaeghen P, Cohen-Cory S, Frisén J, Flanagan JG, Frostig RD. PMID: 10908626; PMCID: PMC6772520.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Visualizing and quantifying evoked cortical activity assessed with intrinsic signal imaging. J Neurosci Methods. 2000 Apr 15; 97(2):157-73.
Chen-Bee CH, Polley DB, Brett-Green B, Prakash N, Kwon MC, Frostig RD. PMID: 10788670.
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PubMed Mentions:
18 Fields:
Translation:
Animals
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A mapping label required for normal scale of body representation in the cortex. Nat Neurosci. 2000 Apr; 3(4):358-65.
Vanderhaeghen P, Lu Q, Prakash N, Frisén J, Walsh CA, Frostig RD, Flanagan JG. PMID: 10725925.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Two directions of plasticity in the sensory-deprived adult cortex. Neuron. 1999 Nov; 24(3):623-37.
Polley DB, Chen-Bee CH, Frostig RD. PMID: 10595514.
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PubMed Mentions:
44 Fields:
Translation:
Animals
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Varying the degree of single-whisker stimulation differentially affects phases of intrinsic signals in rat barrel cortex. J Neurophysiol. 1999 Feb; 81(2):692-701.
Polley DB, Chen-Bee CH, Frostig RD. PMID: 10036270.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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Areal extent quantification of functional representations using intrinsic signal optical imaging. J Neurosci Methods. 1996 Sep; 68(1):27-37.
Chen-Bee CH, Kwon MC, Masino SA, Frostig RD. PMID: 8884610.
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PubMed Mentions:
18 Fields:
Translation:
Animals
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Variability and interhemispheric asymmetry of single-whisker functional representations in rat barrel cortex. J Neurophysiol. 1996 Aug; 76(2):884-94.
Chen-Bee CH, Frostig RD. PMID: 8871206.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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RAPID and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo. Nature. 1996 Jun 20; 381(6584):702-6.
Prakash N, Cohen-Cory S, Frostig RD. PMID: 8649516.
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PubMed Mentions:
21 Fields:
Translation:
Animals
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Quantitative long-term imaging of the functional representation of a whisker in rat barrel cortex. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4942-7.
Masino SA, Frostig RD. PMID: 8643508; PMCID: PMC39384.
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PubMed Mentions:
16 Fields:
Translation:
Animals
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Suprathreshold auditory cortex activation visualized by intrinsic signal optical imaging. Cereb Cortex. 1996 Mar-Apr; 6(2):120-30.
Bakin JS, Kwon MC, Masino SA, Weinberger NM, Frostig RD. PMID: 8670644.
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PubMed Mentions:
20 Fields:
Translation:
Animals
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Cortical point-spread function and long-range lateral interactions revealed by real-time optical imaging of macaque monkey primary visual cortex. J Neurosci. 1994 May; 14(5 Pt 1):2545-68.
Grinvald A, Lieke EE, Frostig RD, Hildesheim R. PMID: 8182427; PMCID: PMC6577512.
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PubMed Mentions:
159 Fields:
Translation:
AnimalsCells
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Characterization of functional organization within rat barrel cortex using intrinsic signal optical imaging through a thinned skull. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):9998-10002.
Masino SA, Kwon MC, Dory Y, Frostig RD. PMID: 8234348; PMCID: PMC47700.
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PubMed Mentions:
46 Fields:
Translation:
Animals
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High-resolution optical imaging of functional brain architecture in the awake monkey. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11559-63.
Grinvald A, Frostig RD, Siegel RM, Bartfeld E. PMID: 1763070; PMCID: PMC53175.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6082-6.
Frostig RD, Lieke EE, Ts'o DY, Grinvald A. PMID: 2117272; PMCID: PMC54476.
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PubMed Mentions:
206 Fields:
Translation:
AnimalsCells
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Functional organization of primate visual cortex revealed by high resolution optical imaging. Science. 1990 Jul 27; 249(4967):417-20.
Ts'o DY, Frostig RD, Lieke EE, Grinvald A. PMID: 2165630.
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PubMed Mentions:
136 Fields:
Translation:
AnimalsCells
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Recurring discharge patterns in multiple spike trains. I. Detection. Biol Cybern. 1990; 62(6):487-93.
Frostig RD, Frostig Z, Harper RM. PMID: 2357472.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Optical imaging of cortical activity: real-time imaging using extrinsic dye-signals and high resolution imaging based on slow intrinsic-signals. Annu Rev Physiol. 1989; 51:543-59.
Lieke EE, Frostig RD, Arieli A, Ts'o DY, Hildesheim R, Grinvald A. PMID: 2653196.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Analysis of frequency components in time series data. J Neurosci Methods. 1987 Nov; 22(1):79-87.
Frostig Z, Frostig RD. PMID: 3695571.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Functional architecture of cortex revealed by optical imaging of intrinsic signals. Nature. 1986 Nov 27-Dec 3; 324(6095):361-4.
Grinvald A, Lieke E, Frostig RD, Gilbert CD, Wiesel TN. PMID: 3785405.
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PubMed Mentions:
325 Fields:
Translation:
AnimalsCells
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Information trains. The technique and its uses in spike train and network analysis, with examples taken from the nucleus parabrachialis medialis during sleep-waking states. Brain Res. 1984 Nov 19; 322(1):67-74.
Frostig RD, Frostig Z, Harper RM. PMID: 6518375.
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PubMed Mentions:
10 Fields:
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The effects of stimuli on the activity and functional connectivity of local neuronal groups in the cat auditory cortex. Brain Res. 1983 Aug 08; 272(2):211-21.
Frostig RD, Gottlieb Y, Vaadia E, Abeles M. PMID: 6616200.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells