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Ron Frostig

Title(s)Professor, Neurobiology & Behavior
Address2219 McGaugh Hall
Zot 4550
Irvine CA 92697
Phone(949) 824-2883, 5031
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    Collapse Research 
    Collapse Research Activities and Funding
    Neurovascular Plasticity
    NIH/NINDS R01NS066001Aug 15, 2010 - Jul 31, 2015
    Role: Principal Investigator
    The Size of a Cortical Representation
    NIH/NINDS R01NS055832Dec 15, 2007 - Nov 30, 2013
    Role: Principal Investigator
    Experience Dependent Plasticity of The Developing Cortex
    NIH/NINDS R01NS048350Sep 15, 2004 - Nov 30, 2009
    Role: Principal Investigator
    Behaviorally Induced Cortical Plasticity
    NIH/NINDS R01NS043165Jul 1, 2003 - Jun 30, 2008
    Role: Principal Investigator
    MECHANISM UNDERLYING NGF-INDUCED CORTICAL PLASTICITY
    NIH/NINDS R01NS039760Jan 1, 2000 - Dec 31, 2004
    Role: Principal Investigator
    SENSORY MODIFICATION OF CORTICAL ORGANIZATION
    NIH/NINDS R01NS034519Aug 19, 1996 - Jun 30, 2001
    Role: Principal Investigator
    FUNCTIONAL CORRELATES OF LEARNING IN THE CEREBRAL CORTEX
    NIH/NIMH R03MH050362Apr 1, 1993 - Mar 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Regularized matrix data clustering and its application to image analysis. Biometrics. 2020 Aug 16. Gao X, Shen W, Zhang L, Hu J, Fortin NJ, Frostig RD, Ombao H. PMID: 32799339.
      View in: PubMed   Mentions:    Fields:    
    2. Spatiotemporal dynamics of pial collateral blood flow following permanent middle cerebral artery occlusion in a rat model of sensory-based protection: a Doppler optical coherence tomography study. Neurophotonics. 2019 Oct; 6(4):045012. Zhu J, Hancock AM, Qi L, Telkmann K, Shahbaba B, Chen Z, Frostig RD. PMID: 31824979.
      View in: PubMed   Mentions:
    3. Hypertension prevents a sensory stimulation-based collateral therapeutic from protecting the cortex from impending ischemic stroke damage in a spontaneously hypersensitive rat model. PLoS One. 2018; 13(10):e0206291. Hancock AM, Frostig RD. PMID: 30352082.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Long-Range, Border-Crossing, Horizontal Axon Radiations Are a Common Feature of Rat Neocortical Regions That Differ in Cytoarchitecture. Front Neuroanat. 2018; 12:50. Johnson BA, Frostig RD. PMID: 29977194.
      View in: PubMed   Mentions:
    5. Special Section Guest Editorial: Pioneers in Neurophotonics: Special Section Honoring Professor Amiram Grinvald. Neurophotonics. 2017 Jul; 4(3):031200. Frostig RD, Petersen CCH. PMID: 28948189.
      View in: PubMed   Mentions:
    6. Testing the effects of sensory stimulation as a collateral-based therapeutic for ischemic stroke in C57BL/6J and CD1 mouse strains. PLoS One. 2017; 12(9):e0183909. Hancock AM, Frostig RD. PMID: 28902897.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    7. Imaging Cajal's neuronal avalanche: how wide-field optical imaging of the point-spread advanced the understanding of neocortical structure-function relationship. Neurophotonics. 2017 Jul; 4(3):031217. Frostig RD, Chen-Bee CH, Johnson BA, Jacobs NS. PMID: 28630879.
      View in: PubMed   Mentions:
    8. Prominent lateral spread of imaged evoked activity beyond cortical columns in barrel cortex provides foundation for coding whisker identity. Neurophotonics. 2017 Jul; 4(3):031218. Jacobs NS, Frostig RD. PMID: 28630880.
      View in: PubMed   Mentions:
    9. Fully distributed absolute blood flow velocity measurement for middle cerebral arteries using Doppler optical coherence tomography. Biomed Opt Express. 2016 Feb 01; 7(2):601-15. Qi L, Zhu J, Hancock AM, Dai C, Zhang X, Frostig RD, Chen Z. PMID: 26977365.
      View in: PubMed   Mentions:
    10. Hyperspectral optical tomography of intrinsic signals in the rat cortex. Neurophotonics. 2015 Oct; 2(4):045003. Konecky SD, Wilson RH, Hagen N, Mazhar A, Tkaczyk TS, Frostig RD, Tromberg BJ. PMID: 26835483.
      View in: PubMed   Mentions:
    11. Long, intrinsic horizontal axons radiating through and beyond rat barrel cortex have spatial distributions similar to horizontal spreads of activity evoked by whisker stimulation. Brain Struct Funct. 2016 09; 221(7):3617-39. Johnson BA, Frostig RD. PMID: 26438334.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Emergence of spatiotemporal invariance in large neuronal ensembles in rat barrel cortex. Front Neural Circuits. 2015; 9:34. Jacobs NS, Chen-Bee CH, Frostig RD. PMID: 26217194.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Photonics meets connectomics: case of diffuse, long-range horizontal projections in rat cortex. Neurophotonics. 2015 Oct; 2(4):041403. Johnson BA, Frostig RD. PMID: 26158017.
      View in: PubMed   Mentions:
    14. Unimodal primary sensory cortices are directly connected by long-range horizontal projections in the rat sensory cortex. Front Neuroanat. 2014; 8:93. Stehberg J, Dang PT, Frostig RD. PMID: 25309339.
      View in: PubMed   Mentions:
    15. Complete protection from impending stroke following permanent middle cerebral artery occlusion in awake, behaving rats. Eur J Neurosci. 2014 Nov; 40(9):3413-21. Lay CC, Frostig RD. PMID: 25216240.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    16. Sensory Stimulation-Based Complete Protection from Ischemic Stroke Remains Stable at 4 Months Post-Occlusion of MCA. J Neurol Disord. 2013 Nov; 1(4):135. Hancock AM, Lay CC, Davis MF, Frostig RD. PMID: 24634892.
      View in: PubMed   Mentions:
    17. Permanent cerebral vessel occlusion via double ligature and transection. J Vis Exp. 2013 Jul 21; (77). Davis MF, Lay C, Frostig RD. PMID: 23912746.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    18. Early stimulation treatment provides complete sensory-induced protection from ischemic stroke under isoflurane anesthesia. Eur J Neurosci. 2013 Aug; 38(3):2445-52. Lay CC, Jacobs N, Hancock AM, Zhou Y, Frostig RD. PMID: 23586641.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    19. Whisker array functional representation in rat barrel cortex: transcendence of one-to-one topography and its underlying mechanism. Front Neural Circuits. 2012; 6:93. Chen-Bee CH, Zhou Y, Jacobs NS, Lim B, Frostig RD. PMID: 23205005.
      View in: PubMed   Mentions: 17     Fields:    
    20. A rat's whiskers point the way toward a novel stimulus-dependent, protective stroke therapy. Neuroscientist. 2013 Jun; 19(3):313-28. Frostig RD, Lay CC, Davis MF. PMID: 23047156.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    21. Mild sensory stimulation protects the aged rodent from cortical ischemic stroke after permanent middle cerebral artery occlusion. J Am Heart Assoc. 2012 Aug; 1(4):e001255. Lay CC, Davis MF, Chen-Bee CH, Frostig RD. PMID: 23130160.
      View in: PubMed   Mentions: 7     Fields:    
    22. Mild sensory stimulation reestablishes cortical function during the acute phase of ischemia. J Neurosci. 2011 Aug 10; 31(32):11495-504. Lay CC, Davis MF, Chen-Bee CH, Frostig RD. PMID: 21832179.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    23. The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: effects of whisker use. Brain Res. 2011 May 04; 1388:39-47. Gomez-Pinilla F, Ying Z, Agoncillo T, Frostig R. PMID: 21385568.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    24. Amount but not pattern of protective sensory stimulation alters recovery after permanent middle cerebral artery occlusion. Stroke. 2011 Mar; 42(3):792-8. Davis MF, Lay CC, Chen-Bee CH, Frostig RD. PMID: 21317269.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    25. Mild sensory stimulation completely protects the adult rodent cortex from ischemic stroke. PLoS One. 2010 Jun 23; 5(6):e11270. Lay CC, Davis MF, Chen-Bee CH, Frostig RD. PMID: 20585659.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    26. Intrinsic signal optical imaging of brain function using short stimulus delivery intervals. J Neurosci Methods. 2010 Mar 30; 187(2):171-82. Chen-Bee CH, Agoncillo T, Lay CC, Frostig RD. PMID: 20079373.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    27. Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination. J Biomed Opt. 2009 Mar-Apr; 14(2):024033. Abookasis D, Lay CC, Mathews MS, Linskey ME, Frostig RD, Tromberg BJ. PMID: 19405762.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    28. Large-scale organization of rat sensorimotor cortex based on a motif of large activation spreads. J Neurosci. 2008 Dec 03; 28(49):13274-84. Frostig RD, Xiong Y, Chen-Bee CH, Kvasnák E, Stehberg J. PMID: 19052219.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    29. The triphasic intrinsic signal: implications for functional imaging. J Neurosci. 2007 Apr 25; 27(17):4572-86. Chen-Bee CH, Agoncillo T, Xiong Y, Frostig RD. PMID: 17460070.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    30. Functional organization and plasticity in the adult rat barrel cortex: moving out-of-the-box. Curr Opin Neurobiol. 2006 Aug; 16(4):445-50. Frostig RD. PMID: 16822663.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    31. Whisker-based discrimination of object orientation determined with a rapid training paradigm. Neurobiol Learn Mem. 2005 Mar; 83(2):134-42. Polley DB, Rickert JL, Frostig RD. PMID: 15721797.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    32. What has intrinsic signal optical imaging taught us about NGF-induced rapid plasticity in adult cortex and its relationship to the cholinergic system? Mol Imaging Biol. 2005 Jan-Feb; 7(1):14-21. Prakash N, Frostig RD. PMID: 15912271.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    33. Naturalistic experience transforms sensory maps in the adult cortex of caged animals. Nature. 2004 May 06; 429(6987):67-71. Polley DB, Kvasnák E, Frostig RD. PMID: 15129281.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    34. Basal forebrain cholinergic system is involved in rapid nerve growth factor (NGF)-induced plasticity in the barrel cortex of adult rats. J Neurophysiol. 2004 Jan; 91(1):424-37. Prakash N, Cohen-Cory S, Penschuck S, Frostig RD. PMID: 14507983.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    35. In vivo modulation of a cortical functional sensory representation shortly after topical cholinergic agent application. J Comp Neurol. 2002 Oct 07; 452(1):38-50. Penschuck S, Chen-Bee CH, Prakash N, Frostig RD. PMID: 12205708.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    36. Comparing the functional representations of central and border whiskers in rat primary somatosensory cortex. J Neurosci. 2001 Dec 15; 21(24):9944-54. Brett-Green BA, Chen-Bee CH, Frostig RD. PMID: 11739601.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    37. Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knock-out mice revealed by in vivo functional imaging. J Neurosci. 2000 Aug 01; 20(15):5841-7. Prakash N, Vanderhaeghen P, Cohen-Cory S, Frisén J, Flanagan JG, Frostig RD. PMID: 10908626.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    38. Visualizing and quantifying evoked cortical activity assessed with intrinsic signal imaging. J Neurosci Methods. 2000 Apr 15; 97(2):157-73. Chen-Bee CH, Polley DB, Brett-Green B, Prakash N, Kwon MC, Frostig RD. PMID: 10788670.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    39. A mapping label required for normal scale of body representation in the cortex. Nat Neurosci. 2000 Apr; 3(4):358-65. Vanderhaeghen P, Lu Q, Prakash N, Frisén J, Walsh CA, Frostig RD, Flanagan JG. PMID: 10725925.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    40. Two directions of plasticity in the sensory-deprived adult cortex. Neuron. 1999 Nov; 24(3):623-37. Polley DB, Chen-Bee CH, Frostig RD. PMID: 10595514.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    41. Varying the degree of single-whisker stimulation differentially affects phases of intrinsic signals in rat barrel cortex. J Neurophysiol. 1999 Feb; 81(2):692-701. Polley DB, Chen-Bee CH, Frostig RD. PMID: 10036270.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    42. Areal extent quantification of functional representations using intrinsic signal optical imaging. J Neurosci Methods. 1996 Sep; 68(1):27-37. Chen-Bee CH, Kwon MC, Masino SA, Frostig RD. PMID: 8884610.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    43. Variability and interhemispheric asymmetry of single-whisker functional representations in rat barrel cortex. J Neurophysiol. 1996 Aug; 76(2):884-94. Chen-Bee CH, Frostig RD. PMID: 8871206.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    44. RAPID and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo. Nature. 1996 Jun 20; 381(6584):702-6. Prakash N, Cohen-Cory S, Frostig RD. PMID: 8649516.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    45. Quantitative long-term imaging of the functional representation of a whisker in rat barrel cortex. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4942-7. Masino SA, Frostig RD. PMID: 8643508.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    46. Suprathreshold auditory cortex activation visualized by intrinsic signal optical imaging. Cereb Cortex. 1996 Mar-Apr; 6(2):120-30. Bakin JS, Kwon MC, Masino SA, Weinberger NM, Frostig RD. PMID: 8670644.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    47. Cortical point-spread function and long-range lateral interactions revealed by real-time optical imaging of macaque monkey primary visual cortex. J Neurosci. 1994 May; 14(5 Pt 1):2545-68. Grinvald A, Lieke EE, Frostig RD, Hildesheim R. PMID: 8182427.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    48. Characterization of functional organization within rat barrel cortex using intrinsic signal optical imaging through a thinned skull. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):9998-10002. Masino SA, Kwon MC, Dory Y, Frostig RD. PMID: 8234348.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    49. High-resolution optical imaging of functional brain architecture in the awake monkey. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11559-63. Grinvald A, Frostig RD, Siegel RM, Bartfeld E. PMID: 1763070.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    50. Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6082-6. Frostig RD, Lieke EE, Ts'o DY, Grinvald A. PMID: 2117272.
      View in: PubMed   Mentions: 185     Fields:    Translation:AnimalsCells
    51. Functional organization of primate visual cortex revealed by high resolution optical imaging. Science. 1990 Jul 27; 249(4967):417-20. Ts'o DY, Frostig RD, Lieke EE, Grinvald A. PMID: 2165630.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    52. Recurring discharge patterns in multiple spike trains. I. Detection. Biol Cybern. 1990; 62(6):487-93. Frostig RD, Frostig Z, Harper RM. PMID: 2357472.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    53. Optical imaging of cortical activity: real-time imaging using extrinsic dye-signals and high resolution imaging based on slow intrinsic-signals. Annu Rev Physiol. 1989; 51:543-59. Lieke EE, Frostig RD, Arieli A, Ts'o DY, Hildesheim R, Grinvald A. PMID: 2653196.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    54. Analysis of frequency components in time series data. J Neurosci Methods. 1987 Nov; 22(1):79-87. Frostig Z, Frostig RD. PMID: 3695571.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    55. Functional architecture of cortex revealed by optical imaging of intrinsic signals. Nature. 1986 Nov 27-Dec 3; 324(6095):361-4. Grinvald A, Lieke E, Frostig RD, Gilbert CD, Wiesel TN. PMID: 3785405.
      View in: PubMed   Mentions: 254     Fields:    Translation:AnimalsCells
    56. Information trains. The technique and its uses in spike train and network analysis, with examples taken from the nucleus parabrachialis medialis during sleep-waking states. Brain Res. 1984 Nov 19; 322(1):67-74. Frostig RD, Frostig Z, Harper RM. PMID: 6518375.
      View in: PubMed   Mentions: 11     Fields:    
    57. The effects of stimuli on the activity and functional connectivity of local neuronal groups in the cat auditory cortex. Brain Res. 1983 Aug 08; 272(2):211-21. Frostig RD, Gottlieb Y, Vaadia E, Abeles M. PMID: 6616200.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
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