Frostig, Ron

Title(s)Professor, Neurobiology & Behavior
Phone(949) 824-2883, 5031
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    Collapse Research 
    Collapse Research Activities and Funding
    Neurovascular Plasticity
    NIH/NINDS R01NS066001Aug 15, 2010 - Jul 31, 2015
    Role: Principal Investigator
    The Size of a Cortical Representation
    NIH/NINDS R01NS055832Dec 15, 2007 - Nov 30, 2013
    Role: Principal Investigator
    Experience Dependent Plasticity of The Developing Cortex
    NIH/NINDS R01NS048350Sep 15, 2004 - Nov 30, 2009
    Role: Principal Investigator
    Behaviorally Induced Cortical Plasticity
    NIH/NINDS R01NS043165Jul 1, 2003 - Jun 30, 2008
    Role: Principal Investigator
    NIH/NINDS R01NS039760Jan 1, 2000 - Dec 31, 2004
    Role: Principal Investigator
    NIH/NINDS R01NS034519Aug 19, 1996 - Jun 30, 2001
    Role: Principal Investigator
    NIH/NIMH R03MH050362Apr 1, 1993 - Mar 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hancock AM, Frostig RD. Hypertension prevents a sensory stimulation-based collateral therapeutic from protecting the cortex from impending ischemic stroke damage in a spontaneously hypersensitive rat model. PLoS One. 2018; 13(10):e0206291. PMID: 30352082.
      View in: PubMed
    2. Johnson BA, Frostig RD. Long-Range, Border-Crossing, Horizontal Axon Radiations Are a Common Feature of Rat Neocortical Regions That Differ in Cytoarchitecture. Front Neuroanat. 2018; 12:50. PMID: 29977194.
      View in: PubMed
    3. Frostig RD, Petersen CCH. Special Section Guest Editorial: Pioneers in Neurophotonics: Special Section Honoring Professor Amiram Grinvald. Neurophotonics. 2017 Jul; 4(3):031200. PMID: 28948189.
      View in: PubMed
    4. Hancock AM, Frostig RD. Testing the effects of sensory stimulation as a collateral-based therapeutic for ischemic stroke in C57BL/6J and CD1 mouse strains. PLoS One. 2017; 12(9):e0183909. PMID: 28902897.
      View in: PubMed
    5. Frostig RD, Chen-Bee CH, Johnson BA, Jacobs NS. Imaging Cajal's neuronal avalanche: how wide-field optical imaging of the point-spread advanced the understanding of neocortical structure-function relationship. Neurophotonics. 2017 Jul; 4(3):031217. PMID: 28630879.
      View in: PubMed
    6. Jacobs NS, Frostig RD. Prominent lateral spread of imaged evoked activity beyond cortical columns in barrel cortex provides foundation for coding whisker identity. Neurophotonics. 2017 Jul; 4(3):031218. PMID: 28630880.
      View in: PubMed
    7. Qi L, Zhu J, Hancock AM, Dai C, Zhang X, Frostig RD, Chen Z. Fully distributed absolute blood flow velocity measurement for middle cerebral arteries using Doppler optical coherence tomography. Biomed Opt Express. 2016 Feb 01; 7(2):601-15. PMID: 26977365; PMCID: PMC4771474.
    8. Konecky SD, Wilson RH, Hagen N, Mazhar A, Tkaczyk TS, Frostig RD, Tromberg BJ. Hyperspectral optical tomography of intrinsic signals in the rat cortex. Neurophotonics. 2015 Oct; 2(4):045003. PMID: 26835483; PMCID: PMC4718192 [Available on 11/12/16].
    9. Jacobs NS, Chen-Bee CH, Frostig RD. Emergence of spatiotemporal invariance in large neuronal ensembles in rat barrel cortex. Front Neural Circuits. 2015; 9:34. PMID: 26217194; PMCID: PMC4495341.
    10. Johnson BA, Frostig RD. Photonics meets connectomics: case of diffuse, long-range horizontal projections in rat cortex. Neurophotonics. 2015 Oct; 2(4):041403. PMID: 26158017; PMCID: PMC4478784 [Available on 10/01/16].
    11. Stehberg J, Dang PT, Frostig RD. Unimodal primary sensory cortices are directly connected by long-range horizontal projections in the rat sensory cortex. Front Neuroanat. 2014; 8:93. PMID: 25309339; PMCID: PMC4174042.
    12. Lay CC, Frostig RD. Complete protection from impending stroke following permanent middle cerebral artery occlusion in awake, behaving rats. Eur J Neurosci. 2014 Nov; 40(9):3413-21. PMID: 25216240; PMCID: PMC4218886.
    13. Hancock AM, Lay CC, Davis MF, Frostig RD. Sensory Stimulation-Based Complete Protection from Ischemic Stroke Remains Stable at 4 Months Post-Occlusion of MCA. J Neurol Disord. 2013 Nov; 1(4):135. PMID: 24634892.
      View in: PubMed
    14. Davis MF, Lay C, Frostig RD. Permanent cerebral vessel occlusion via double ligature and transection. J Vis Exp. 2013 Jul 21; (77). PMID: 23912746; PMCID: PMC3845834.
    15. Lay CC, Jacobs N, Hancock AM, Zhou Y, Frostig RD. Early stimulation treatment provides complete sensory-induced protection from ischemic stroke under isoflurane anesthesia. Eur J Neurosci. 2013 Aug; 38(3):2445-52. PMID: 23586641; PMCID: PMC3735829.
    16. Chen-Bee CH, Zhou Y, Jacobs NS, Lim B, Frostig RD. Whisker array functional representation in rat barrel cortex: transcendence of one-to-one topography and its underlying mechanism. Front Neural Circuits. 2012; 6:93. PMID: 23205005; PMCID: PMC3506988.
    17. Frostig RD, Lay CC, Davis MF. A rat's whiskers point the way toward a novel stimulus-dependent, protective stroke therapy. Neuroscientist. 2013 Jun; 19(3):313-28. PMID: 23047156; PMCID: PMC3710106.
    18. Lay CC, Davis MF, Chen-Bee CH, Frostig RD. Mild sensory stimulation protects the aged rodent from cortical ischemic stroke after permanent middle cerebral artery occlusion. J Am Heart Assoc. 2012 Aug; 1(4):e001255. PMID: 23130160; PMCID: PMC3487352.
    19. Lay CC, Davis MF, Chen-Bee CH, Frostig RD. Mild sensory stimulation reestablishes cortical function during the acute phase of ischemia. J Neurosci. 2011 Aug 10; 31(32):11495-504. PMID: 21832179; PMCID: PMC3162364.
    20. Gomez-Pinilla F, Ying Z, Agoncillo T, Frostig R. The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: effects of whisker use. Brain Res. 2011 May 04; 1388:39-47. PMID: 21385568; PMCID: PMC3225184.
    21. Davis MF, Lay CC, Chen-Bee CH, Frostig RD. Amount but not pattern of protective sensory stimulation alters recovery after permanent middle cerebral artery occlusion. Stroke. 2011 Mar; 42(3):792-8. PMID: 21317269; PMCID: PMC3141731.
    22. Lay CC, Davis MF, Chen-Bee CH, Frostig RD. Mild sensory stimulation completely protects the adult rodent cortex from ischemic stroke. PLoS One. 2010 Jun 23; 5(6):e11270. PMID: 20585659; PMCID: PMC2890583.
    23. Chen-Bee CH, Agoncillo T, Lay CC, Frostig RD. Intrinsic signal optical imaging of brain function using short stimulus delivery intervals. J Neurosci Methods. 2010 Mar 30; 187(2):171-82. PMID: 20079373; PMCID: PMC2832718.
    24. Abookasis D, Lay CC, Mathews MS, Linskey ME, Frostig RD, Tromberg BJ. Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination. J Biomed Opt. 2009 Mar-Apr; 14(2):024033. PMID: 19405762; PMCID: PMC2868516.
    25. Frostig RD, Xiong Y, Chen-Bee CH, Kvasnák E, Stehberg J. Large-scale organization of rat sensorimotor cortex based on a motif of large activation spreads. J Neurosci. 2008 Dec 03; 28(49):13274-84. PMID: 19052219; PMCID: PMC2710304.
    26. Chen-Bee CH, Agoncillo T, Xiong Y, Frostig RD. The triphasic intrinsic signal: implications for functional imaging. J Neurosci. 2007 Apr 25; 27(17):4572-86. PMID: 17460070.
      View in: PubMed
    27. Frostig RD. Functional organization and plasticity in the adult rat barrel cortex: moving out-of-the-box. Curr Opin Neurobiol. 2006 Aug; 16(4):445-50. PMID: 16822663.
      View in: PubMed
    28. Polley DB, Rickert JL, Frostig RD. Whisker-based discrimination of object orientation determined with a rapid training paradigm. Neurobiol Learn Mem. 2005 Mar; 83(2):134-42. PMID: 15721797.
      View in: PubMed
    29. Prakash N, Frostig RD. What has intrinsic signal optical imaging taught us about NGF-induced rapid plasticity in adult cortex and its relationship to the cholinergic system? Mol Imaging Biol. 2005 Jan-Feb; 7(1):14-21. PMID: 15912271.
      View in: PubMed
    30. Polley DB, Kvasnák E, Frostig RD. Naturalistic experience transforms sensory maps in the adult cortex of caged animals. Nature. 2004 May 06; 429(6987):67-71. PMID: 15129281.
      View in: PubMed
    31. Prakash N, Cohen-Cory S, Penschuck S, Frostig RD. Basal forebrain cholinergic system is involved in rapid nerve growth factor (NGF)-induced plasticity in the barrel cortex of adult rats. J Neurophysiol. 2004 Jan; 91(1):424-37. PMID: 14507983.
      View in: PubMed
    32. Penschuck S, Chen-Bee CH, Prakash N, Frostig RD. In vivo modulation of a cortical functional sensory representation shortly after topical cholinergic agent application. J Comp Neurol. 2002 Oct 07; 452(1):38-50. PMID: 12205708.
      View in: PubMed