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Chang C. Liu

Title(s)Assistant Professor, Biomedical Engineering
SchoolSamueli School of Engineering
Address3105 Natural Sciences II
Zot 2715
Irvine CA 92697
Phone(949) 824-8534
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    Collapse Research 
    Collapse research activities and funding
    Making antibody generation rapid, scalable, and democratic through machine learning and continuous evolution
    NIH R01CA260415Sep 10, 2020 - Aug 31, 2025
    Role: Principal Investigator
    Synthetic genetic systems for rapid biomolecular evolution in vivo
    NIH R35GM136297Jun 1, 2020 - May 31, 2025
    Role: Principal Investigator
    A genetically-encoded device that counts cell cycles
    NIH R21GM126287Mar 1, 2018 - Feb 29, 2020
    Role: Principal Investigator
    A High-Throughput Continuous Evolution System for in vivo Biosensor Engineering
    NIH DP2GM119163Sep 30, 2015 - May 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The role of plasmid copy number and mutation rate in evolutionary outcomes. Nat Ecol Evol. 2025 Sep; 9(9):1694-1704. Pisera A', Liu CC. PMID: 40659873.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation. Nat Commun. 2025 May 24; 16(1):4832. Furuhata Y, Rix G, Van Deventer JA, Liu CC. PMID: 40413191; PMCID: PMC12103617.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    3. Open-ended molecular recording of sequential cellular events into DNA. Nat Chem Biol. 2025 Apr; 21(4):512-521. Loveless TB, Carlson CK, Dentzel Helmy CA, Hu VJ, Ross SK, Demelo MC, Murtaza A, Liang G, Ficht M, Singhai A, Pajoh-Casco MJ, Liu CC. PMID: 39543397; PMCID: PMC11952980.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    4. The Impact of Nanobodies on G Protein-Coupled Receptor Structural Biology and Their Potential as Therapeutic Agents. Mol Pharmacol. 2024 Sep 17; 106(4):155-163. Salom D, Wu A, Liu CC, Palczewski K. PMID: 39107078; PMCID: PMC11413913.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Rapid generation of potent antibodies by autonomous hypermutation in yeast. Nat Chem Biol. 2021 10; 17(10):1057-1064. Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. PMID: 34168368; PMCID: PMC8463502.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    6. Systems for in vivo hypermutation: a quest for scale and depth in directed evolution. Curr Opin Chem Biol. 2021 10; 64:20-26. Rix G, Liu CC. PMID: 33784581; PMCID: PMC8464631.
      View in: PubMed   Mentions: 21     Fields:    
    7. Lineage tracing and analog recording in mammalian cells by single-site DNA writing. Nat Chem Biol. 2021 06; 17(6):739-747. Loveless TB, Grotts JH, Schechter MW, Forouzmand E, Carlson CK, Agahi BS, Liang G, Ficht M, Liu B, Xie X, Liu CC. PMID: 33753928; PMCID: PMC8891441.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    8. Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities. Nat Commun. 2020 11 06; 11(1):5644. Rix G, Watkins-Dulaney EJ, Almhjell PJ, Boville CE, Arnold FH, Liu CC. PMID: 33159067; PMCID: PMC7648111.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    9. A new path to tyrosine sulfation. Nat Chem Biol. 2020 04; 16(4):365-366. Liu CC. PMID: 32198494.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Scalable, Continuous Evolution of Genes at Mutation Rates above Genomic Error Thresholds. Cell. 2018 12 13; 175(7):1946-1957.e13. Ravikumar A, Arzumanyan GA, Obadi MKA, Javanpour AA, Liu CC. PMID: 30415839; PMCID: PMC6343851.
      View in: PubMed   Mentions: 125     Fields:    Translation:Animals
    11. Site-Specific Incorporation of Sulfotyrosine Using an Expanded Genetic Code. Methods Mol Biol. 2018; 1728:191-200. Li X, Liu CC. PMID: 29404999.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    12. Biocontainment through reengineered genetic codes. Chembiochem. 2015 May 26; 16(8):1149-51. Ravikumar A, Liu CC. PMID: 25917937.
      View in: PubMed   Mentions: 8     Fields:    
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