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Philip Kiser

Title(s)Assistant Professor, Physiology And Biophysics
Phone(949) 824-6954
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    Collapse Research 
    Collapse Research Activities and Funding
    Studies on visual cycles and their relevance to age-related macular degeneration
    VA IK2BX002683Apr 1, 2015 - Apr 1, 2020
    Role: Principal Investigator
    Retinoids in Vision
    NIH/NEI R01EY009339Aug 1, 1992 - Jul 31, 1992
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Daruwalla A, Kiser PD. Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs). Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec 23; 158590. PMID: 31874225.
      View in: PubMed
    2. Montano MM, Yeh IJ, Chen Y, Hernandez C, Kiselar JG, de la Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, Lawes MC. Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. Breast Cancer Res. 2019 12 05; 21(1):138. PMID: 31805991.
      View in: PubMed
    3. Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019 Dec 13; 294(50):19137-19154. PMID: 31694912.
      View in: PubMed
    4. Khadka N, Farquhar ER, Hill HE, Shi W, von Lintig J, Kiser PD. Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J Biol Chem. 2019 07 05; 294(27):10596-10606. PMID: 31138651.
      View in: PubMed
    5. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 Apr; 33(4):5782-5792. PMID: 30645148.
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    6. Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 10 22; 475(20):3171-3188. PMID: 30352831.
      View in: PubMed
    7. Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 07 01; 27(13):2225-2243. PMID: 29659842.
      View in: PubMed
    8. Sui X, Farquhar ER, Hill HE, von Lintig J, Shi W, Kiser PD. Preparation and characterization of metal-substituted carotenoid cleavage oxygenases. J Biol Inorg Chem. 2018 08; 23(6):887-901. PMID: 29946976.
      View in: PubMed
    9. Kelly ME, Ramkumar S, Sun W, Colon Ortiz C, Kiser PD, Golczak M, von Lintig J. The Biochemical Basis of Vitamin A Production from the Asymmetric Carotenoid ß-Cryptoxanthin. ACS Chem Biol. 2018 08 17; 13(8):2121-2129. PMID: 29883100.
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    10. Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 05 18; 9(1):1996. PMID: 29777099.
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    11. Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018 04 02; 150(4):571-590. PMID: 29500274.
      View in: PubMed
    12. Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 02; 364(2):207-220. PMID: 29162627.
      View in: PubMed
    13. Silvaroli JA, Pleshinger MJ, Banerjee S, Kiser PD, Golczak M. Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa. ACS Chem Biol. 2017 09 15; 12(9):2296-2304. PMID: 28708375.
      View in: PubMed
    14. Kiser PD. Reappraisal of dioxygen binding in NOV1 crystal structures. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):E6027-E6028. PMID: 28679636.
      View in: PubMed
    15. Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017 06 06; 56(22):2836-2852. PMID: 28493664.
      View in: PubMed
    16. Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther. 2017 07; 362(1):131-145. PMID: 28476927.
      View in: PubMed
    17. Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2608-E2615. PMID: 28289214.
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    18. Chen Y, Kern TS, Kiser PD, Palczewski K. Eyes on systems pharmacology. Pharmacol Res. 2016 Dec; 114:39-41. PMID: 27720767.
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    19. Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci Signal. 2016 07 26; 9(438):ra74. PMID: 27460988.
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    20. Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J Biol Chem. 2016 09 09; 291(37):19401-12. PMID: 27453555.
      View in: PubMed
    21. Kiser PD, Palczewski K. Retinoids and Retinal Diseases. Annu Rev Vis Sci. 2016 10; 2:197-234. PMID: 27917399.
      View in: PubMed
    22. Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage. J Biol Chem. 2016 Jun 17; 291(25):12951-9. PMID: 27129240.
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    23. Lobo GP, Au A, Kiser PD, Hagstrom SA. Involvement of Endoplasmic Reticulum Stress in TULP1 Induced Retinal Degeneration. PLoS One. 2016; 11(3):e0151806. PMID: 26987071.
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    24. Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. The Biochemical Basis of Vitamin A3 Production in Arthropod Vision. ACS Chem Biol. 2016 Apr 15; 11(4):1049-57. PMID: 26811964.
      View in: PubMed
    25. Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. J Biol Chem. 2015 Dec 18; 290(51):30212-23. PMID: 26499794.
      View in: PubMed
    26. Babino D, Palczewski G, Widjaja-Adhi MA, Kiser PD, Golczak M, von Lintig J. Characterization of the Role of ß-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism. J Biol Chem. 2015 Oct 09; 290(41):24844-57. PMID: 26307071.
      View in: PubMed
    27. Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 2015 Jul 01; 125(7):2781-94. PMID: 26075817.
      View in: PubMed
    28. Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun; 11(6):409-15. PMID: 25894083.
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    29. Golczak M, Sears AE, Kiser PD, Palczewski K. LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. Nat Chem Biol. 2015 Jan; 11(1):26-32. PMID: 25383759.
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    30. Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Mol Pharmacol. 2014 Aug; 86(2):231-42. PMID: 24913940.
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    31. Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K. Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO). J Biol Chem. 2014 May 02; 289(18):12286-99. PMID: 24648526.
      View in: PubMed
    32. Kiser PD, Golczak M, Palczewski K. Chemistry of the retinoid (visual) cycle. Chem Rev. 2014 Jan 08; 114(1):194-232. PMID: 23905688.
      View in: PubMed
    33. Sui X, Kiser PD, Lintig Jv, Palczewski K. Structural basis of carotenoid cleavage: from bacteria to mammals. Arch Biochem Biophys. 2013 Nov 15; 539(2):203-13. PMID: 23827316.
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    34. Kowatz T, Babino D, Kiser P, Palczewski K, von Lintig J. Characterization of human ß,ß-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme. Arch Biochem Biophys. 2013 Nov 15; 539(2):214-22. PMID: 23727499.
      View in: PubMed
    35. Palczewski K, Kiser PD. Biochemistry. As good as chocolate. Science. 2013 May 03; 340(6132):562-3. PMID: 23641106.
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    36. Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2747-56. PMID: 23012475.
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    37. Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J Biol Chem. 2012 Jul 06; 287(28):23790-807. PMID: 22605381.
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    38. Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. J Biol Chem. 2012 Apr 13; 287(16):13356-70. PMID: 22356908.
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    39. Kiser PD, Golczak M, Maeda A, Palczewski K. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012 Jan; 1821(1):137-51. PMID: 21447403.
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    40. Kiser PD, Palczewski K. Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res. 2010 Sep; 29(5):428-42. PMID: 20304090.
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    41. von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci. 2010 Jul; 35(7):400-10. PMID: 20188572.
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    42. Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010 Mar 26; 285(13):9667-82. PMID: 20100834.
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    43. Bereta G, Wang B, Kiser PD, Baehr W, Jang GF, Palczewski K. A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. J Biol Chem. 2010 Jan 15; 285(3):1899-908. PMID: 19901021.
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    44. Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17325-30. PMID: 19805034.
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    45. Kiser PD, Lorimer GH, Palczewski K. Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 01; 65(Pt 10):967-71. PMID: 19851000.
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    46. Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K. Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry. 2008 Sep 16; 47(37):9856-65. PMID: 18722466.
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    47. Golczak M, Maeda A, Bereta G, Maeda T, Kiser PD, Hunzelmann S, von Lintig J, Blaner WS, Palczewski K. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem. 2008 Apr 11; 283(15):9543-54. PMID: 18195010.
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    48. Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. J Am Chem Soc. 2008 Jan 30; 130(4):1154-5. PMID: 18179220.
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    49. Kiser PD, Lodowski DT, Palczewski K. Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 01; 63(Pt 6):457-61. PMID: 17554162.
      View in: PubMed
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