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Philip Kiser

Title(s)Assistant Professor, Physiology and Biophysics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6954
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    Collapse Research 
    Collapse Research Activities and Funding
    Modulation of retinoid reactivity and pathological signaling in retinal therapeutics
    VA I01BX004939Apr 1, 2020 - Mar 31, 2024
    Role: Principal Investigator
    Studies on visual cycles and their relevance to age-related macular degeneration
    VA IK2BX002683Apr 1, 2015 - Apr 1, 2020
    Role: Principal Investigator
    Retinoids in Vision
    NIH/NEI R01EY009339Aug 1, 1992 - Jul 31, 1992
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs). Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec 23; 158590. Daruwalla A, Kiser PD. PMID: 31874225.
      View in: PubMed   Mentions:    Fields:    
    2. Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. Breast Cancer Res. 2019 12 05; 21(1):138. Montano MM, Yeh IJ, Chen Y, Hernandez C, Kiselar JG, de la Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, Lawes MC. PMID: 31805991.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019 12 13; 294(50):19137-19154. Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. PMID: 31694912.
      View in: PubMed   Mentions:    Fields:    
    4. Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J Biol Chem. 2019 07 05; 294(27):10596-10606. Khadka N, Farquhar ER, Hill HE, Shi W, von Lintig J, Kiser PD. PMID: 31138651.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 04; 33(4):5782-5792. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. PMID: 30645148.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 10 22; 475(20):3171-3188. Daruwalla A, Choi EH, Palczewski K, Kiser PD. PMID: 30352831.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 07 01; 27(13):2225-2243. Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. PMID: 29659842.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Preparation and characterization of metal-substituted carotenoid cleavage oxygenases. J Biol Inorg Chem. 2018 08; 23(6):887-901. Sui X, Farquhar ER, Hill HE, von Lintig J, Shi W, Kiser PD. PMID: 29946976.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    9. The Biochemical Basis of Vitamin A Production from the Asymmetric Carotenoid ß-Cryptoxanthin. ACS Chem Biol. 2018 08 17; 13(8):2121-2129. Kelly ME, Ramkumar S, Sun W, Colon Ortiz C, Kiser PD, Golczak M, von Lintig J. PMID: 29883100.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    10. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 05 18; 9(1):1996. Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. PMID: 29777099.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018 04 02; 150(4):571-590. Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. PMID: 29500274.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 02; 364(2):207-220. Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. PMID: 29162627.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa. ACS Chem Biol. 2017 09 15; 12(9):2296-2304. Silvaroli JA, Pleshinger MJ, Banerjee S, Kiser PD, Golczak M. PMID: 28708375.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Reappraisal of dioxygen binding in NOV1 crystal structures. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):E6027-E6028. Kiser PD. PMID: 28679636.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    15. Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017 06 06; 56(22):2836-2852. Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. PMID: 28493664.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    16. Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther. 2017 07; 362(1):131-145. Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. PMID: 28476927.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    17. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2608-E2615. Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. PMID: 28289214.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. Eyes on systems pharmacology. Pharmacol Res. 2016 Dec; 114:39-41. Chen Y, Kern TS, Kiser PD, Palczewski K. PMID: 27720767.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    19. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci Signal. 2016 07 26; 9(438):ra74. Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. PMID: 27460988.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    20. Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J Biol Chem. 2016 09 09; 291(37):19401-12. Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. PMID: 27453555.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    21. Retinoids and Retinal Diseases. Annu Rev Vis Sci. 2016 10; 2:197-234. Kiser PD, Palczewski K. PMID: 27917399.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    22. Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage. J Biol Chem. 2016 Jun 17; 291(25):12951-9. Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. PMID: 27129240.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Involvement of Endoplasmic Reticulum Stress in TULP1 Induced Retinal Degeneration. PLoS One. 2016; 11(3):e0151806. Lobo GP, Au A, Kiser PD, Hagstrom SA. PMID: 26987071.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    24. The Biochemical Basis of Vitamin A3 Production in Arthropod Vision. ACS Chem Biol. 2016 Apr 15; 11(4):1049-57. Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. PMID: 26811964.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    25. Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. J Biol Chem. 2015 Dec 18; 290(51):30212-23. Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. PMID: 26499794.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    26. Characterization of the Role of ß-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism. J Biol Chem. 2015 Oct 09; 290(41):24844-57. Babino D, Palczewski G, Widjaja-Adhi MA, Kiser PD, Golczak M, von Lintig J. PMID: 26307071.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    27. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 2015 Jul 01; 125(7):2781-94. Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. PMID: 26075817.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    28. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun; 11(6):409-15. Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. PMID: 25894083.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    29. LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. Nat Chem Biol. 2015 Jan; 11(1):26-32. Golczak M, Sears AE, Kiser PD, Palczewski K. PMID: 25383759.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    30. Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Mol Pharmacol. 2014 Aug; 86(2):231-42. Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. PMID: 24913940.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    31. Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO). J Biol Chem. 2014 May 02; 289(18):12286-99. Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K. PMID: 24648526.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    32. Chemistry of the retinoid (visual) cycle. Chem Rev. 2014 Jan 08; 114(1):194-232. Kiser PD, Golczak M, Palczewski K. PMID: 23905688.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    33. Structural basis of carotenoid cleavage: from bacteria to mammals. Arch Biochem Biophys. 2013 Nov 15; 539(2):203-13. Sui X, Kiser PD, Lintig Jv, Palczewski K. PMID: 23827316.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    34. Characterization of human ß,ß-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme. Arch Biochem Biophys. 2013 Nov 15; 539(2):214-22. Kowatz T, Babino D, Kiser P, Palczewski K, von Lintig J. PMID: 23727499.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    35. Biochemistry. As good as chocolate. Science. 2013 May 03; 340(6132):562-3. Palczewski K, Kiser PD. PMID: 23641106.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2747-56. Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. PMID: 23012475.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    37. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J Biol Chem. 2012 Jul 06; 287(28):23790-807. Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. PMID: 22605381.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    38. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. J Biol Chem. 2012 Apr 13; 287(16):13356-70. Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. PMID: 22356908.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    39. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012 Jan; 1821(1):137-51. Kiser PD, Golczak M, Maeda A, Palczewski K. PMID: 21447403.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    40. Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res. 2010 Sep; 29(5):428-42. Kiser PD, Palczewski K. PMID: 20304090.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    41. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci. 2010 Jul; 35(7):400-10. von Lintig J, Kiser PD, Golczak M, Palczewski K. PMID: 20188572.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    42. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010 Mar 26; 285(13):9667-82. Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. PMID: 20100834.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    43. A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. J Biol Chem. 2010 Jan 15; 285(3):1899-908. Bereta G, Wang B, Kiser PD, Baehr W, Jang GF, Palczewski K. PMID: 19901021.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    44. Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17325-30. Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. PMID: 19805034.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    45. Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 01; 65(Pt 10):967-71. Kiser PD, Lorimer GH, Palczewski K. PMID: 19851000.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    46. Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry. 2008 Sep 16; 47(37):9856-65. Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K. PMID: 18722466.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    47. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem. 2008 Apr 11; 283(15):9543-54. Golczak M, Maeda A, Bereta G, Maeda T, Kiser PD, Hunzelmann S, von Lintig J, Blaner WS, Palczewski K. PMID: 18195010.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    48. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. J Am Chem Soc. 2008 Jan 30; 130(4):1154-5. Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. PMID: 18179220.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    49. Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 01; 63(Pt 6):457-61. Kiser PD, Lodowski DT, Palczewski K. PMID: 17554162.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
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