Philip Kiser

Title(s)Associate Professor, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6954
ORCID ORCID Icon0000-0003-1184-9539 Additional info
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Case Western Reserve University, Cleveland, OHPh.D.04/2010Pharmacology
    St. Louis College of Pharmacy, St. Louis, MOPharm.D.05/2005Pharmacy
    Collapse Awards and Honors
    Research to Prevent Blindness2024  - 2025Career Advancement Award
    International Carotenoid Society2023Fellow
    Lighthouse Guild2021Pisart Award in Vision Science
    Department of Veterans Affairs2015  - 2020Career Development Award (CDA-2)
    National Institutes of Health2006  - 2010Pediatric Research Loan Repayment Program Award

    Collapse Overview 
    Collapse Overview
    My laboratory studies the enzymes, transporters and binding proteins that comprise a metabolic pathway known as the visual cycle as well as a variety of other proteins important for the health of the retina. We use an array of experimental techniques and methodologies, including X-ray crystallography, electron microscopy, knockout mouse models, and classic biochemistry approaches to answer important questions about the structure and function of these proteins. Major emphasis is placed on the use of such information to develop effective therapeutics for currently untreatable retinal diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Retinoid Cycles and Retinal Disease Treatment
    Department of Veterans Affairs I02BX004939Apr 1, 2024 - Mar 31, 2028
    Role: Principal Investigator
    Chemical Biology of the Vertebrate Visual Pigments
    NEI R01EY034519Mar 1, 2023 - Feb 28, 2027
    Role: Principal Investigator
    Unraveling the principles of catalytic diversity in the carotenoid oxygenase superfamily
    NSF 2107713Sep 1, 2021 - Aug 31, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis. Trends Biochem Sci. 2024 May 17. Solano YJ, Kiser PD. PMID: 38760195.
      View in: PubMed   Mentions:    Fields:    
    2. Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors. Cell Rep. 2024 May 28; 43(5):114143. Bassetto M, Kolesnikov AV, Lewandowski D, Kiser JZ, Halabi M, Einstein DE, Choi EH, Palczewski K, Kefalov VJ, Kiser PD. PMID: 38676924; PMCID: PMC11211020.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice. J Biol Chem. 2024 May; 300(5):107291. Lewandowski D, Gao F, Imanishi S, Tworak A, Bassetto M, Dong Z, Pinto AFM, Tabaka M, Kiser PD, Imanishi Y, Skowronska-Krawczyk D, Palczewski K. PMID: 38636661; PMCID: PMC11107370.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore. Nat Chem Biol. 2024 Feb 14. Solano YJ, Everett MP, Dang KS, Abueg J, Kiser PD. PMID: 38355721.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Retinylidene chromophore hydrolysis from mammalian visual and non-visual opsins. J Biol Chem. 2024 Mar; 300(3):105678. Hong JD, Salom D, Choi EH, Du SW, Tworak A, Smidak R, Gao F, Solano YJ, Zhang J, Kiser PD, Palczewski K. PMID: 38272218; PMCID: PMC10877631.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun. 2023 08 25; 14(1):5209. Wu A, Salom D, Hong JD, Tworak A, Watanabe K, Pardon E, Steyaert J, Kandori H, Katayama K, Kiser PD, Palczewski K. PMID: 37626045; PMCID: PMC10457330.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia. Cell Rep. 2023 08 29; 42(8):112982. Tworak A, Kolesnikov AV, Hong JD, Choi EH, Luu JC, Palczewska G, Dong Z, Lewandowski D, Brooks MJ, Campello L, Swaroop A, Kiser PD, Kefalov VJ, Palczewski K. PMID: 37585292; PMCID: PMC10530494.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif. J Med Chem. 2023 06 22; 66(12):8140-8158. Bassetto M, Zaluski J, Li B, Zhang J, Badiee M, Kiser PD, Tochtrop GP. PMID: 37279401; PMCID: PMC10824489.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    9. Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2221045120. Luu JC, Saadane A, Leinonen H, Choi EH, Gao F, Lewandowski D, Halabi M, Sander CL, Wu A, Wang JM, Singh R, Gao S, Lessieur EM, Dong Z, Palczewska G, Mullins RF, Peachey NS, Kiser PD, Tabaka M, Kern TS, Palczewski K. PMID: 37126699; PMCID: PMC10175720.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Chromophore hydrolysis and release from photoactivated rhodopsin in native membranes. Proc Natl Acad Sci U S A. 2022 Nov 08; 119(45):e2213911119. Hong JD, Salom D, Kochman MA, Kubas A, Kiser PD, Palczewski K. PMID: 36322748; PMCID: PMC9659404.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    11. Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration. Curr Biol. 2022 10 24; 32(20):4538-4546.e5. Huh CYL, Leinonen H, Nakayama T, Tomasello JR, Zhang J, Zeitoun J, Peach JP, Halabi M, Kiser JZ, Palczewski K, Kiser PD, Gandhi SP. PMID: 36152631; PMCID: PMC10083103.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    12. A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Hum Mol Genet. 2022 04 22; 31(8):1263-1277. Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA, 99 Lives Consortium, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, Vincent A, Mahroo OA, Kiser PD, Petersen-Jones SM. PMID: 34726233; PMCID: PMC9029234.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    13. Preparation of carotenoid cleavage dioxygenases for X-ray crystallography. Methods Enzymol. 2022; 671:243-271. Daruwalla A, Sui X, Kiser PD. PMID: 35878980; PMCID: PMC10809780.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    14. Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure. 2022 02 03; 30(2):263-277.e5. Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. PMID: 34678158; PMCID: PMC8818024.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. Retinal pigment epithelium 65 kDa protein (RPE65): An update. Prog Retin Eye Res. 2022 05; 88:101013. Kiser PD. PMID: 34607013; PMCID: PMC8975950.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    16. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol. 2021 08 02; 220(8). Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, Palczewski K. PMID: 34132745; PMCID: PMC8240855.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    17. Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J Med Chem. 2021 06 24; 64(12):8287-8302. Blum E, Zhang J, Zaluski J, Einstein DE, Korshin EE, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. PMID: 34081480; PMCID: PMC8381290.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021 05 10; 6(9). Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. PMID: 33784255; PMCID: PMC8262343.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    19. Structure of 3-mercaptopropionic acid dioxygenase with a substrate analog reveals bidentate substrate binding at the iron center. J Biol Chem. 2021 Jan-Jun; 296:100492. York NJ, Lockart MM, Sardar S, Khadka N, Shi W, Stenkamp RE, Zhang J, Kiser PD, Pierce BS. PMID: 33662397; PMCID: PMC8050391.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    20. The Structural and Biochemical Basis of Apocarotenoid Processing by β-Carotene Oxygenase-2. ACS Chem Biol. 2021 03 19; 16(3):480-490. Bandara S, Thomas LD, Ramkumar S, Khadka N, Kiser PD, Golczak M, von Lintig J. PMID: 33600157; PMCID: PMC8082539.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    21. Function of mammalian M-cones depends on the level of CRALBP in Müller cells. J Gen Physiol. 2021 01 04; 153(1). Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. PMID: 33216847; PMCID: PMC7685772.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. J Biol Chem. 2021 Jan-Jun; 296:100072. Kiser PD, Palczewski K. PMID: 33187985; PMCID: PMC7948990.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    23. Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2020 Nov; 4(11):1119. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. PMID: 33122854.
      View in: PubMed   Mentions: 2     Fields:    
    24. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021 02; 5(2):169-178. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. PMID: 33077938; PMCID: PMC7885272.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    25. The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids. J Biol Chem. 2020 11 13; 295(46):15553-15565. Thomas LD, Bandara S, Parmar VM, Srinivasagan R, Khadka N, Golczak M, Kiser PD, von Lintig J. PMID: 32873706; PMCID: PMC7667965.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    26. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. FASEB J. 2020 10; 34(10):13918-13934. Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. PMID: 32860273; PMCID: PMC7589273.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    27. Shedding new light on the generation of the visual chromophore. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):19629-19638. Palczewski K, Kiser PD. PMID: 32759209; PMCID: PMC7443880.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    28. Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):19914-19925. Daruwalla A, Zhang J, Lee HJ, Khadka N, Farquhar ER, Shi W, von Lintig J, Kiser PD. PMID: 32747548; PMCID: PMC7443882.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    29. Genetic Basis of De Novo Appearance of Carotenoid Ornamentation in Bare Parts of Canaries. Mol Biol Evol. 2020 05 01; 37(5):1317-1328. Gazda MA, Toomey MB, Araújo PM, Lopes RJ, Afonso S, Myers CA, Serres K, Kiser PD, Hill GE, Corbo JC, Carneiro M. PMID: 31930402.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    30. Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs). Biochim Biophys Acta Mol Cell Biol Lipids. 2020 11; 1865(11):158590. Daruwalla A, Kiser PD. PMID: 31874225; PMCID: PMC7308199.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    31. Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. Breast Cancer Res. 2019 12 05; 21(1):138. Montano MM, Yeh IJ, Chen Y, Hernandez C, Kiselar JG, de la Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, Lawes MC. PMID: 31805991; PMCID: PMC6896798.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    32. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019 12 13; 294(50):19137-19154. Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. PMID: 31694912; PMCID: PMC6916499.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    33. Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J Biol Chem. 2019 07 05; 294(27):10596-10606. Khadka N, Farquhar ER, Hill HE, Shi W, von Lintig J, Kiser PD. PMID: 31138651; PMCID: PMC6615678.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    34. Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1. ACS Chem Biol. 2019 03 15; 14(3):434-448. Silvaroli JA, Widjaja-Adhi MAK, Trischman T, Chelstowska S, Horwitz S, Banerjee S, Kiser PD, Blaner WS, Golczak M. PMID: 30721022; PMCID: PMC6420351.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    35. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 04; 33(4):5782-5792. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. PMID: 30645148; PMCID: PMC6436658.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    36. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 10 22; 475(20):3171-3188. Daruwalla A, Choi EH, Palczewski K, Kiser PD. PMID: 30352831; PMCID: PMC6440480.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    37. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 07 01; 27(13):2225-2243. Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. PMID: 29659842; PMCID: PMC6005012.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    38. Preparation and characterization of metal-substituted carotenoid cleavage oxygenases. J Biol Inorg Chem. 2018 08; 23(6):887-901. Sui X, Farquhar ER, Hill HE, von Lintig J, Shi W, Kiser PD. PMID: 29946976; PMCID: PMC6060882.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    39. The Biochemical Basis of Vitamin A Production from the Asymmetric Carotenoid β-Cryptoxanthin. ACS Chem Biol. 2018 08 17; 13(8):2121-2129. Kelly ME, Ramkumar S, Sun W, Colon Ortiz C, Kiser PD, Golczak M, von Lintig J. PMID: 29883100; PMCID: PMC6158786.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    40. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 05 18; 9(1):1996. Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. PMID: 29777099; PMCID: PMC5959942.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    41. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018 04 02; 150(4):571-590. Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. PMID: 29500274; PMCID: PMC5881442.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    42. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 02; 364(2):207-220. Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. PMID: 29162627; PMCID: PMC5771314.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    43. Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa. ACS Chem Biol. 2017 09 15; 12(9):2296-2304. Silvaroli JA, Pleshinger MJ, Banerjee S, Kiser PD, Golczak M. PMID: 28708375; PMCID: PMC5693239.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    44. Reappraisal of dioxygen binding in NOV1 crystal structures. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):E6027-E6028. Kiser PD. PMID: 28679636; PMCID: PMC5544326.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    45. Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017 06 06; 56(22):2836-2852. Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. PMID: 28493664; PMCID: PMC5541372.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    46. Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther. 2017 07; 362(1):131-145. Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. PMID: 28476927; PMCID: PMC5490204.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    47. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2608-E2615. Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. PMID: 28289214; PMCID: PMC5380078.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    48. Eyes on systems pharmacology. Pharmacol Res. 2016 Dec; 114:39-41. Chen Y, Kern TS, Kiser PD, Palczewski K. PMID: 27720767; PMCID: PMC5154905.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    49. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci Signal. 2016 07 26; 9(438):ra74. Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. PMID: 27460988; PMCID: PMC4972460.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    50. Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J Biol Chem. 2016 09 09; 291(37):19401-12. Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. PMID: 27453555; PMCID: PMC5016679.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    51. Retinoids and Retinal Diseases. Annu Rev Vis Sci. 2016 10; 2:197-234. Kiser PD, Palczewski K. PMID: 27917399; PMCID: PMC5132409.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    52. Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage. J Biol Chem. 2016 Jun 17; 291(25):12951-9. Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. PMID: 27129240; PMCID: PMC4933214.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    53. Involvement of Endoplasmic Reticulum Stress in TULP1 Induced Retinal Degeneration. PLoS One. 2016; 11(3):e0151806. Lobo GP, Au A, Kiser PD, Hagstrom SA. PMID: 26987071; PMCID: PMC4795779.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    54. Ligand Binding Induces Conformational Changes in Human Cellular Retinol-binding Protein 1 (CRBP1) Revealed by Atomic Resolution Crystal Structures. J Biol Chem. 2016 Apr 15; 291(16):8528-40. Silvaroli JA, Arne JM, Chelstowska S, Kiser PD, Banerjee S, Golczak M. PMID: 26900151; PMCID: PMC4861425.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    55. The Biochemical Basis of Vitamin A3 Production in Arthropod Vision. ACS Chem Biol. 2016 Apr 15; 11(4):1049-57. Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. PMID: 26811964; PMCID: PMC4841470.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    56. Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. J Biol Chem. 2015 Dec 18; 290(51):30212-23. Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. PMID: 26499794; PMCID: PMC4683246.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    57. Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism. J Biol Chem. 2015 Oct 09; 290(41):24844-57. Babino D, Palczewski G, Widjaja-Adhi MA, Kiser PD, Golczak M, von Lintig J. PMID: 26307071; PMCID: PMC4598995.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    58. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 2015 Jul 01; 125(7):2781-94. Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. PMID: 26075817; PMCID: PMC4563688.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    59. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun; 11(6):409-15. Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. PMID: 25894083; PMCID: PMC4433804.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    60. LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. Nat Chem Biol. 2015 Jan; 11(1):26-32. Golczak M, Sears AE, Kiser PD, Palczewski K. PMID: 25383759; PMCID: PMC4270908.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    61. Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Mol Pharmacol. 2014 Aug; 86(2):231-42. Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. PMID: 24913940; PMCID: PMC4127928.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    62. Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO). J Biol Chem. 2014 May 02; 289(18):12286-99. Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K. PMID: 24648526; PMCID: PMC4007427.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    63. Chemistry of the retinoid (visual) cycle. Chem Rev. 2014 Jan 08; 114(1):194-232. Kiser PD, Golczak M, Palczewski K. PMID: 23905688; PMCID: PMC3858459.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    64. Structural basis of carotenoid cleavage: from bacteria to mammals. Arch Biochem Biophys. 2013 Nov 15; 539(2):203-13. Sui X, Kiser PD, Lintig Jv, Palczewski K. PMID: 23827316; PMCID: PMC3818509.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    65. Characterization of human β,β-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme. Arch Biochem Biophys. 2013 Nov 15; 539(2):214-22. Kowatz T, Babino D, Kiser P, Palczewski K, von Lintig J. PMID: 23727499; PMCID: PMC3795993.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    66. Biochemistry. As good as chocolate. Science. 2013 May 03; 340(6132):562-3. Palczewski K, Kiser PD. PMID: 23641106; PMCID: PMC4596528.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    67. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2747-56. Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. PMID: 23012475; PMCID: PMC3478654.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    68. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J Biol Chem. 2012 Jul 06; 287(28):23790-807. Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. PMID: 22605381; PMCID: PMC3390653.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    69. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. J Biol Chem. 2012 Apr 13; 287(16):13356-70. Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. PMID: 22356908; PMCID: PMC3339940.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    70. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012 Jan; 1821(1):137-51. Kiser PD, Golczak M, Maeda A, Palczewski K. PMID: 21447403; PMCID: PMC3158816.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    71. Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res. 2010 Sep; 29(5):428-42. Kiser PD, Palczewski K. PMID: 20304090; PMCID: PMC2903629.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    72. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci. 2010 Jul; 35(7):400-10. von Lintig J, Kiser PD, Golczak M, Palczewski K. PMID: 20188572; PMCID: PMC2891588.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    73. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010 Mar 26; 285(13):9667-9682. Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. PMID: 20100834; PMCID: PMC2843217.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    74. A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. J Biol Chem. 2010 Jan 15; 285(3):1899-908. Bereta G, Wang B, Kiser PD, Baehr W, Jang GF, Palczewski K. PMID: 19901021; PMCID: PMC2804348.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    75. Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17325-30. Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. PMID: 19805034; PMCID: PMC2765077.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    76. Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 01; 65(Pt 10):967-71. Kiser PD, Lorimer GH, Palczewski K. PMID: 19851000; PMCID: PMC2765879.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    77. Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry. 2008 Sep 16; 47(37):9856-65. Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K. PMID: 18722466; PMCID: PMC2610467.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    78. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem. 2008 Apr 11; 283(15):9543-54. Golczak M, Maeda A, Bereta G, Maeda T, Kiser PD, Hunzelmann S, von Lintig J, Blaner WS, Palczewski K. PMID: 18195010; PMCID: PMC2441898.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    79. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. J Am Chem Soc. 2008 Jan 30; 130(4):1154-5. Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. PMID: 18179220; PMCID: PMC2621334.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    80. Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 01; 63(Pt 6):457-61. Kiser PD, Lodowski DT, Palczewski K. PMID: 17554162; PMCID: PMC2335072.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    81. A comprehensive structure-function map of the intracellular surface of the human C5a receptor. I. Identification of critical residues. J Biol Chem. 2007 Feb 02; 282(5):3105-21. Matsumoto ML, Narzinski K, Kiser PD, Nikiforovich GV, Baranski TJ. PMID: 17135254.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    82. Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter. Protein Sci. 2006 Oct; 15(10):2411-22. White KJ, Kiser PD, Nichols DE, Barker EL. PMID: 17008722; PMCID: PMC2242390.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    Philip's Networks
    Concepts (328)
    Derived automatically from this person's publications.
    Co-Authors (9)
    People in Profiles who have published with this person.
    Similar People (60)
    People who share similar concepts with this person.
    Same Department
    Search Department