David Christian Lyon

Title(s)Professor, Anatomy and Neurobiology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-0447
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    Collapse Research 
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    Viral strategies for bi-directional optogenetic control of specific cell types in neocortex of non-transgenic animals
    NIH R21NS113264Jul 15, 2020 - Jun 30, 2022
    Role: Principal Investigator
    Role of cell-type specific circuits in visual processing
    NIH R01EY024890Jan 1, 2015 - Dec 31, 2019
    Role: Principal Investigator
    Cell Type Specific Tracing of Neocortical Circuits Using Viral Vectors
    NIH R21NS072948May 1, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Contextual modulation of orientation specificity in V1
    NIH F32EY014521Sep 26, 2002 - Sep 25, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Medial ganglionic eminence transplantation restores inhibition after central visual system brain injury. PNAS Nexus. 2025 Mar; 4(3):pgaf077. Hou B, Eom J, Lyon DC, Hunt RF. PMID: 40099222; PMCID: PMC11913217.
      View in: PubMed   Mentions:
    2. Cortical reorganization following dorsal spinal injuries in newborn monkeys reveals a critical period in the development of the somatosensory cortex. Proc Natl Acad Sci U S A. 2025 Jan 28; 122(4):e2417417122. Jain N, Qi HX, Raman A, Lyon D, Kaas JH. PMID: 39835892; PMCID: PMC11789031.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations. Nat Biomed Eng. 2025 Jan; 9(1):57-78. Holubowicz R, Du SW, Felgner J, Smidak R, Choi EH, Palczewska G, Menezes CR, Dong Z, Gao F, Medani O, Yan AL, Holubowicz MW, Chen PZ, Bassetto M, Risaliti E, Salom D, Workman JN, Kiser PD, Foik AT, Lyon DC, Newby GA, Liu DR, Felgner PL, Palczewski K. PMID: 39609561; PMCID: PMC11754100.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Polyunsaturated Fatty Acid - mediated Cellular Rejuvenation for Reversing Age-related Vision Decline. bioRxiv. 2024 Jul 02. Gao F, Tom E, Rydz C, Cho W, Kolesnikov AV, Sha Y, Papadam A, Jafari S, Joseph A, Ahanchi A, Saraei NBS, Lyon D, Foik A, Nie Q, Grassmann F, Kefalov VJ, Skowronska-Krawczyk D. PMID: 39005302; PMCID: PMC11244954.
      View in: PubMed   Mentions:
    5. Stress induced aging in mouse eye. Aging Cell. 2022 Dec; 21(12):e13737. Xu Q, Rydz C, Nguyen Huu VA, Rocha L, Palomino La Torre C, Lee I, Cho W, Jabari M, Donello J, Lyon DC, Brooke RT, Horvath S, Weinreb RN, Ju WK, Foik A, Skowronska-Krawczyk D. PMID: 36397653; PMCID: PMC9741506.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    6. Visual System Hyperexcitability and Compromised V1 Receptive Field Properties in Early-Stage Retinitis Pigmentosa in Mice. eNeuro. 2022 May-Jun; 9(3). Leinonen H, Lyon DC, Palczewski K, Foik AT. PMID: 35701168; PMCID: PMC9239850.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    7. Brain-wide reconstruction of inhibitory circuits after traumatic brain injury. Nat Commun. 2022 06 14; 13(1):3417. Frankowski JC, Tierno A, Pavani S, Cao Q, Lyon DC, Hunt RF. PMID: 35701434; PMCID: PMC9197933.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    8. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nat Commun. 2022 04 05; 13(1):1830. Choi EH, Suh S, Foik AT, Leinonen H, Newby GA, Gao XD, Banskota S, Hoang T, Du SW, Dong Z, Raguram A, Kohli S, Blackshaw S, Lyon DC, Liu DR, Palczewski K. PMID: 35383196; PMCID: PMC8983734.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    9. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. JCI Insight. 2022 02 22; 7(4). Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu J, Lee J, Ma X, Bieberich E, Blackshaw S, Saghatelian A, Lyon DC, Skowronska-Krawczyk D, Tabaka M, Palczewski K. PMID: 35015730; PMCID: PMC8876453.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    10. Traumatic brain injury to primary visual cortex produces long-lasting circuit dysfunction. Commun Biol. 2021 11 17; 4(1):1297. Frankowski JC, Foik AT, Tierno A, Machhor JR, Lyon DC, Hunt RF. PMID: 34789835; PMCID: PMC8599505.
      View in: PubMed   Mentions: 8  Translation:AnimalsCells
    11. Closing the methane gap in US oil and natural gas production emissions inventories. Nat Commun. 2021 08 05; 12(1):4715. Rutherford JS, Sherwin ED, Ravikumar AP, Heath GA, Englander J, Cooley D, Lyon D, Omara M, Langfitt Q, Brandt AR. PMID: 34354066; PMCID: PMC8342509.
      View in: PubMed   Mentions: 28     Fields:    
    12. Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2020 Nov; 4(11):1119. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. PMID: 33122854.
      View in: PubMed   Mentions: 1     Fields:    
    13. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021 02; 5(2):169-178. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. PMID: 33077938; PMCID: PMC7885272.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    14. Visual Response Characteristics in Lateral and Medial Subdivisions of the Rat Pulvinar. Neuroscience. 2020 08 10; 441:117-130. Foik AT, Scholl LR, Lean GA, Lyon DC. PMID: 32599121; PMCID: PMC7398122.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    15. Projections between visual cortex and pulvinar in the rat. J Comp Neurol. 2021 01; 529(1):129-140. Scholl LR, Foik AT, Lyon DC. PMID: 32361987; PMCID: PMC7606250.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    16. Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation. Nat Commun. 2019 03 05; 10(1):1055. Hansen BK, Gupta R, Baldus L, Lyon D, Narita T, Lammers M, Choudhary C, Weinert BT. PMID: 30837475; PMCID: PMC6401094.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    17. Quantitative metaproteomics of medieval dental calculus reveals individual oral health status. Nat Commun. 2018 11 20; 9(1):4744. Jersie-Christensen RR, Lanigan LT, Lyon D, Mackie M, Belstrøm D, Kelstrup CD, Fotakis AK, Willerslev E, Lynnerup N, Jensen LJ, Cappellini E, Olsen JV. PMID: 30459334; PMCID: PMC6246597.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    18. Detailed Visual Cortical Responses Generated by Retinal Sheet Transplants in Rats with Severe Retinal Degeneration. J Neurosci. 2018 12 12; 38(50):10709-10724. Foik AT, Lean GA, Scholl LR, McLelland BT, Mathur A, Aramant RB, Seiler MJ, Lyon DC. PMID: 30396913; PMCID: PMC6290293.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    19. Site-specific characterization of endogenous SUMOylation across species and organs. Nat Commun. 2018 06 25; 9(1):2456. Hendriks IA, Lyon D, Su D, Skotte NH, Daniel JA, Jensen LJ, Nielsen ML. PMID: 29942033; PMCID: PMC6018634.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    20. Cell type specific tracing of the subcortical input to primary visual cortex from the basal forebrain. J Comp Neurol. 2019 02 15; 527(3):589-599. Lean GA, Liu YJ, Lyon DC. PMID: 29441578; PMCID: PMC6092244.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    21. Differences in orientation tuning between pinwheel and domain neurons in primary visual cortex depend on contrast and size. Neurophotonics. 2017 Jul; 4(3):031209. Liu YJ, Hashemi-Nezhad M, Lyon DC. PMID: 28523280; PMCID: PMC5429862.
      View in: PubMed   Mentions: 3  
    22. V1 connections reveal a series of elongated higher visual areas in the California ground squirrel, Otospermophilus beecheyi. J Comp Neurol. 2017 Jun 01; 525(8):1909-1921. Negwer M, Liu YJ, Schubert D, Lyon DC. PMID: 28078786.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    23. Contrast invariance of orientation tuning in cat primary visual cortex neurons depends on stimulus size. J Physiol. 2015 Oct 01; 593(19):4485-98. Liu YJ, Hashemi-Nezhad M, Lyon DC. PMID: 26227285; PMCID: PMC4594239.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. Resolving the organization of the territory of the third visual area: a new proposal. Vis Neurosci. 2015 Jan; 32:E016. Kaas JH, Roe AW, Baldwin MK, Lyon DC. PMID: 26241553.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    25. Very-long-range disynaptic V1 connections through layer 6 pyramidal neurons revealed by transneuronal tracing with rabies virus. Eye Brain. 2014; 6(Suppl 1):45-56. Liu YJ, Arreola M, Coleman CM, Lyon DC. PMID: 28539788; PMCID: PMC5417745.
      View in: PubMed   Mentions: 7  
    26. Distribution of cortical neurons projecting to the superior colliculus in macaque monkeys. Eye Brain. 2014 Sep 23; 2014(6):121-137. Cerkevich CM, Lyon DC, Balaram P, Kaas JH. PMID: 25663799; PMCID: PMC4316385.
      View in: PubMed   Mentions: 16  
    27. Tracing inputs to inhibitory or excitatory neurons of mouse and cat visual cortex with a targeted rabies virus. Curr Biol. 2013 Sep 23; 23(18):1746-55. Liu YJ, Ehrengruber MU, Negwer M, Shao HJ, Cetin AH, Lyon DC. PMID: 23993841; PMCID: PMC3786040.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    28. Sharper orientation tuning of the extraclassical suppressive-surround due to a neuron's location in the V1 orientation map emerges late in time. Neuroscience. 2013 Jan 15; 229:100-17. Liu YJ, Hashemi-Nezhad M, Lyon DC. PMID: 23159311.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Lack of robust LGN label following transneuronal rabies virus injections into macaque area V4. J Comp Neurol. 2012 Aug 01; 520(11):2500-11. Lyon DC, Rabideau C. PMID: 22237967.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    30. Parallel feedback pathways in visual cortex of cats revealed through a modified rabies virus. J Comp Neurol. 2012 Apr 01; 520(5):988-1004. Connolly JD, Hashemi-Nezhad M, Lyon DC. PMID: 21826663.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    31. The case for primate V3. Proc Biol Sci. 2012 Feb 22; 279(1729):625-33. Lyon DC, Connolly JD. PMID: 22171081; PMCID: PMC3248742.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    32. Orientation tuning of the suppressive extraclassical surround depends on intrinsic organization of V1. Cereb Cortex. 2012 Feb; 22(2):308-26. Hashemi-Nezhad M, Lyon DC. PMID: 21666124.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    33. Dynamics of extraclassical surround modulation in three types of V1 neurons. J Neurophysiol. 2011 Mar; 105(3):1306-17. Liu YJ, Hashemi-Nezhad M, Lyon DC. PMID: 21228302.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    34. A disynaptic relay from superior colliculus to dorsal stream visual cortex in macaque monkey. Neuron. 2010 Jan 28; 65(2):270-9. Lyon DC, Nassi JJ, Callaway EM. PMID: 20152132; PMCID: PMC2832737.
      View in: PubMed   Mentions: 91     Fields:    
    35. Functional organization of motor cortex of adult macaque monkeys is altered by sensory loss in infancy. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3192-7. Qi HX, Jain N, Collins CE, Lyon DC, Kaas JH. PMID: 20133738; PMCID: PMC2840311.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    36. The operating regime of local computations in primary visual cortex. Cereb Cortex. 2009 Sep; 19(9):2166-80. Stimberg M, Wimmer K, Martin R, Schwabe L, Mariño J, Schummers J, Lyon DC, Sur M, Obermayer K. PMID: 19221143; PMCID: PMC2722429.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    37. Pulvinar contributions to the dorsal and ventral streams of visual processing in primates. Brain Res Rev. 2007 Oct; 55(2):285-96. Kaas JH, Lyon DC. PMID: 17433837; PMCID: PMC2100380.
      View in: PubMed   Mentions: 114     Fields:    
    38. The organization of frontoparietal cortex in the tree shrew (Tupaia belangeri): II. Connectional evidence for a frontal-posterior parietal network. J Comp Neurol. 2007 Mar 01; 501(1):121-49. Remple MS, Reed JL, Stepniewska I, Lyon DC, Kaas JH. PMID: 17206607.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    39. Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons. Neuron. 2007 Mar 01; 53(5):639-47. Wickersham IR, Lyon DC, Barnard RJ, Mori T, Finke S, Conzelmann KK, Young JA, Callaway EM. PMID: 17329205; PMCID: PMC2629495.
      View in: PubMed   Mentions: 533     Fields:    
    40. The parvocellular LGN provides a robust disynaptic input to the visual motion area MT. Neuron. 2006 Apr 20; 50(2):319-27. Nassi JJ, Lyon DC, Callaway EM. PMID: 16630841; PMCID: PMC3398675.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    41. Distribution across cortical areas of neurons projecting to the superior colliculus in new world monkeys. Anat Rec A Discov Mol Cell Evol Biol. 2005 Jul; 285(1):619-27. Collins CE, Lyon DC, Kaas JH. PMID: 15912524.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    42. Invariant computations in local cortical networks with balanced excitation and inhibition. Nat Neurosci. 2005 Feb; 8(2):194-201. Mariño J, Schummers J, Lyon DC, Schwabe L, Beck O, Wiesing P, Obermayer K, Sur M. PMID: 15665876.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    43. The visual pulvinar in tree shrews I. Multiple subdivisions revealed through acetylcholinesterase and Cat-301 chemoarchitecture. J Comp Neurol. 2003 Dec 22; 467(4):593-606. Lyon DC, Jain N, Kaas JH. PMID: 14624491.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    44. The visual pulvinar in tree shrews II. Projections of four nuclei to areas of visual cortex. J Comp Neurol. 2003 Dec 22; 467(4):607-27. Lyon DC, Jain N, Kaas JH. PMID: 14624492.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    45. Responses of neurons in the middle temporal visual area after long-standing lesions of the primary visual cortex in adult new world monkeys. J Neurosci. 2003 Mar 15; 23(6):2251-64. Collins CE, Lyon DC, Kaas JH. PMID: 12657684; PMCID: PMC6742043.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    46. Optical imaging reveals retinotopic organization of dorsal V3 in New World owl monkeys. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15735-42. Lyon DC, Xu X, Casagrande VA, Stefansic JD, Shima D, Kaas JH. PMID: 12441399; PMCID: PMC137785.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    47. Evidence from V1 connections for both dorsal and ventral subdivisions of V3 in three species of New World monkeys. J Comp Neurol. 2002 Jul 29; 449(3):281-97. Lyon DC, Kaas JH. PMID: 12115680.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    48. Cortical and thalamic connections of the parietal ventral somatosensory area in marmoset monkeys (Callithrix jacchus). J Comp Neurol. 2002 Feb 04; 443(2):168-82. Qi HX, Lyon DC, Kaas JH. PMID: 11793354.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    49. Evidence for a modified V3 with dorsal and ventral halves in macaque monkeys. Neuron. 2002 Jan 31; 33(3):453-61. Lyon DC, Kaas JH. PMID: 11832231.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    50. Connectional evidence for dorsal and ventral V3, and other extrastriate areas in the prosimian primate, Galago garnetti. Brain Behav Evol. 2002; 59(3):114-29. Lyon DC, Kaas JH. PMID: 12119531.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    51. Connectional and architectonic evidence for dorsal and ventral V3, and dorsomedial area in marmoset monkeys. J Neurosci. 2001 Jan 01; 21(1):249-61. Lyon DC, Kaas JH. PMID: 11150342; PMCID: PMC6762432.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    52. Visual cortex organization in primates: theories of V3 and adjoining visual areas. Prog Brain Res. 2001; 134:285-95. Kaas JH, Lyon DC. PMID: 11702549.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    53. Cortical organization in shrews: evidence from five species. J Comp Neurol. 1999 Jul 19; 410(1):55-72. Catania KC, Lyon DC, Mock OB, Kaas JH. PMID: 10397395.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    54. Cortical connections of striate and extrastriate visual areas in tree shrews. J Comp Neurol. 1998 Nov 09; 401(1):109-28. Lyon DC, Jain N, Kaas JH. PMID: 9802703.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    55. Evaluation of three culture media and their combinations for the isolation of Mycobacterium tuberculosis from pleural aspirates of patients with tuberculous pleurisy. J Trop Med Hyg. 1994 Aug; 97(4):249-53. Cheng AF, Li MS, Chan CY, Chan CH, Lyon D, Wise R, Lee JC. PMID: 8064950.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
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