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Civelli, Olivier

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentPharmacology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-2522, 2591
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    Collapse Research 
    Collapse Research Activities and Funding
    Upstream control and downstream effects of NPS release
    NIH/NIMH R21MH093521Sep 19, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Role of Neuropeptide S in age-related cognitive decline
    NIH/NIA R21AG039863Apr 1, 2011 - Mar 31, 2014
    Role: Principal Investigator
    A novel neuropeptide system involved in drug abuse
    NIH/NIDA R01DA024746Feb 1, 2010 - Jan 31, 2015
    Role: Principal Investigator
    High-Throughput Assay for G-Protein Coupled Receptors in Pain Research
    NIH/NIDA R03DA026557Sep 1, 2008 - Feb 28, 2010
    Role: Principal Investigator
    High-throughput assays for GPCR in obesity research
    NIH/NIDDK R01DK070619Jun 1, 2005 - Nov 30, 2008
    Role: Principal Investigator
    Novel Glycoprotein Hormone-Like proteins
    NIH/NIDDK R01DK063001Apr 1, 2003 - Feb 28, 2008
    Role: Principal Investigator
    Characterization of two novel neuropeptides
    NIH/NIMH R01MH060231Sep 1, 1999 - Sep 30, 2009
    Role: Principal Investigator
    DOPAMINE D4 RECEPTOR
    NIH/NIMH R01MH048991May 1, 1992 - Apr 30, 1996
    Role: Co-Principal Investigator
    BIOSENSOR APPLICATIONS IN NEURORECEPTOR RESEARCH
    NIH/NIMH R03MH048728Apr 1, 1992 - Mar 31, 1994
    Role: Co-Principal Investigator
    CLONING AND EXPRESSION OF A NEW NEURORECEPTOR
    NIH/NIMH R01MH045614May 1, 1989 - Mar 31, 1992
    Role: Principal Investigator
    REGULATION OF EXPRESSION OF OPIOID PEPTIDES
    NIH/NIDDK R01DK037231Sep 1, 1985 - Sep 30, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang Y, Liu Y, Wu L, Fan C, Wang Z, Zhang X, Alachkar A, Liang X, Civelli O. Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3. FASEB J. 2018 Jan 22; fj201700337RR. PMID: 29401613.
      View in: PubMed
    2. Sanathara NM, Garau C, Alachkar A, Wang L, Wang Z, Nishimori K, Xu X, Civelli O. Melanin concentrating hormone modulates oxytocin-mediated marble burying. Neuropharmacology. 2018 Jan; 128:22-32. PMID: 28888943.
      View in: PubMed
    3. Alachkar A, Wang L, Yoshimura R, Hamzeh AR, Wang Z, Sanathara N, Lee SM, Xu X, Abbott GW, Civelli O. Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits. Mol Psychiatry. 2018 Feb; 23(2):282-294. PMID: 28809400.
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    4. Wang L, Zhang Y, Wang Z, Gong N, Kweon TD, Vo B, Wang C, Zhang X, Chung JY, Alachkar A, Liang X, Luo DZ, Civelli O. The Antinociceptive Properties of the Corydalis yanhusuo Extract. PLoS One. 2016; 11(9):e0162875. PMID: 27622550; PMCID: PMC5021270.
    5. Alachkar A, Alhassen L, Wang Z, Wang L, Onouye K, Sanathara N, Civelli O. Inactivation of the melanin concentrating hormone system impairs maternal behavior. Eur Neuropsychopharmacol. 2016 11; 26(11):1826-1835. PMID: 27617778.
      View in: PubMed
    6. Zhang Y, Long Z, Guo Z, Wang Z, Zhang X, Ye RD, Liang X, Civelli O. Hydroxycinnamic acid amides from Scopolia tangutica inhibit the activity of M1 muscarinic acetylcholine receptor in vitro. Fitoterapia. 2016 Jan; 108:9-12. PMID: 26586621; PMCID: PMC4698058 [Available on 01/01/17].
    7. Wang L, Alachkar A, Sanathara N, Belluzzi JD, Wang Z, Civelli O. A Methionine-Induced Animal Model of Schizophrenia: Face and Predictive Validity. Int J Neuropsychopharmacol. 2015 May 19; 18(12). PMID: 25991655; PMCID: PMC4675974.
    8. Long Z, Zhang Y, Guo Z, Wang L, Xue X, Zhang X, Wang S, Wang Z, Civelli O, Liang X. Amide alkaloids from Scopolia tangutica. Planta Med. 2014 Aug; 80(13):1124-30. PMID: 25127021.
      View in: PubMed
    9. Zhang Y, Wang C, Guo Z, Zhang X, Wang Z, Liang X, Civelli O. Discovery of N-methyltetrahydroprotoberberines with ?-opioid receptor agonists-opioid receptor agonist activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography. J Ethnopharmacol. 2014 Sep 29; 155(3):1597-602. PMID: 25107388.
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    10. Parks GS, Wang L, Wang Z, Civelli O. Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons. J Comp Neurol. 2014 Dec 01; 522(17):3817-33. PMID: 24978951; PMCID: PMC4167928.
    11. Parks GS, Olivas ND, Ikrar T, Sanathara NM, Wang L, Wang Z, Civelli O, Xu X. Histamine inhibits the melanin-concentrating hormone system: implications for sleep and arousal. J Physiol. 2014 May 15; 592(10):2183-96. PMID: 24639485; PMCID: PMC4227902.
    12. Zhang Y, Wang C, Wang L, Parks GS, Zhang X, Guo Z, Ke Y, Li KW, Kim MK, Vo B, Borrelli E, Ge G, Yang L, Wang Z, Garcia-Fuster MJ, Luo ZD, Liang X, Civelli O. A novel analgesic isolated from a traditional Chinese medicine. Curr Biol. 2014 Jan 20; 24(2):117-23. PMID: 24388848; PMCID: PMC3912990.
    13. Grabli D, Karachi C, Folgoas E, Monfort M, Tande D, Clark S, Civelli O, Hirsch EC, François C. Gait disorders in parkinsonian monkeys with pedunculopontine nucleus lesions: a tale of two systems. J Neurosci. 2013 Jul 17; 33(29):11986-93. PMID: 23864685.
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    14. Hopf FW, Seif T, Chung S, Civelli O. MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro. PeerJ. 2013; 1:e61. PMID: 23646281; PMCID: PMC3642701.
    15. Zhang L, Parks GS, Wang Z, Wang L, Lew M, Civelli O. Anatomical characterization of bombesin receptor subtype-3 mRNA expression in the rodent central nervous system. J Comp Neurol. 2013 Apr 01; 521(5):1020-39. PMID: 22911445.
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    16. Civelli O. Orphan GPCRs and neuromodulation. Neuron. 2012 Oct 04; 76(1):12-21. PMID: 23040803; PMCID: PMC3474844.
    17. Urbano M, Guerrero M, Zhao J, Velaparthi S, Saldanha SA, Chase P, Wang Z, Civelli O, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E. Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7). Bioorg Med Chem Lett. 2012 Dec 01; 22(23):7135-41. PMID: 23079522; PMCID: PMC3601546.
    18. Civelli O, Reinscheid RK, Zhang Y, Wang Z, Fredriksson R, Schiöth HB. G protein-coupled receptor deorphanizations. Annu Rev Pharmacol Toxicol. 2013; 53:127-46. PMID: 23020293.
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    19. Chung S, Liao XH, Di Cosmo C, Van Sande J, Wang Z, Refetoff S, Civelli O. Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function. Endocrinology. 2012 Dec; 153(12):6145-54. PMID: 23024261; PMCID: PMC3512057.
    20. Zhang Y, Xu J, Wang Z, Zhang X, Liang X, Civelli O. BmK-YA, an enkephalin-like peptide in scorpion venom. PLoS One. 2012; 7(7):e40417. PMID: 22792309; PMCID: PMC3392217.
    21. García-Fuster MJ, Parks GS, Clinton SM, Watson SJ, Akil H, Civelli O. The melanin-concentrating hormone (MCH) system in an animal model of depression-like behavior. Eur Neuropsychopharmacol. 2012 Aug; 22(8):607-13. PMID: 22209364; PMCID: PMC3319808.
    22. Zhang Y, Wang Z, Cox DP, Civelli O. Study on the activation of the opioid receptors by a set of morphine derivatives in a well-defined assay system. Neurochem Res. 2012 Feb; 37(2):410-6. PMID: 22002663.
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    23. Chung S, Verheij MM, Hesseling P, van Vugt RW, Buell M, Belluzzi JD, Geyer MA, Martens GJ, Civelli O. The melanin-concentrating hormone (MCH) system modulates behaviors associated with psychiatric disorders. PLoS One. 2011; 6(7):e19286. PMID: 21818251; PMCID: PMC3139593.
    24. Zhang Y, Wang Z, Parks GS, Civelli O. Novel neuropeptides as ligands of orphan G protein-coupled receptors. Curr Pharm Des. 2011; 17(25):2626-31. PMID: 21728976.
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    25. Parks GS, Okumura SM, Gohil K, Civelli O. Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures. Neurosci Lett. 2010 Oct 29; 484(2):104-7. PMID: 20709149; PMCID: PMC2943056.
    26. Lee C, Parks GS, Civelli O. Anxiolytic effects of the MCH1R antagonist TPI 1361-17. J Mol Neurosci. 2011 Feb; 43(2):132-7. PMID: 20635163; PMCID: PMC3026772.
    27. Chung S, Parks GS, Lee C, Civelli O. Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists. J Mol Neurosci. 2011 Jan; 43(1):115-21. PMID: 20582487; PMCID: PMC3018593.
    28. Chung S, Wong T, Nagasaki H, Civelli O. Acute homeostatic responses to increased fat consumption in MCH1R knockout mice. J Mol Neurosci. 2010 Nov; 42(3):459-63. PMID: 20411353; PMCID: PMC2955453.
    29. Chung S, Saito Y, Civelli O. MCH receptors/gene structure-in vivo expression. Peptides. 2009 Nov; 30(11):1985-9. PMID: 19647772; PMCID: PMC2764003.
    30. Zhang L, Nothacker HP, Wang Z, Bohn LM, Civelli O. Pharmacological characterization of a selective agonist for bombesin receptor subtype-3. Biochem Biophys Res Commun. 2009 Sep 18; 387(2):283-8. PMID: 19580790; PMCID: PMC2747518.
    31. Chung S, Hopf FW, Nagasaki H, Li CY, Belluzzi JD, Bonci A, Civelli O. The melanin-concentrating hormone system modulates cocaine reward. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6772-7. PMID: 19342492; PMCID: PMC2672513.
    32. Nagasaki H, Chung S, Dooley CT, Wang Z, Li C, Saito Y, Clark SD, Houghten RA, Civelli O. The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries. Eur J Pharmacol. 2009 Jan 14; 602(2-3):194-202. PMID: 19041642; PMCID: PMC2633472.
    33. Okajima Y, Nagasaki H, Suzuki C, Suga H, Ozaki N, Arima H, Hamada Y, Civelli O, Oiso Y. Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5). Regul Pept. 2008 Jun 05; 148(1-3):62-7. PMID: 18433898.
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    34. Civelli O, Zhou QY. Orphan G protein-coupled receptors and novel neuropeptides. Introduction. Results Probl Cell Differ. 2008; 46:v-vi. PMID: 18634199.
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    35. Civelli O. The orphanin FQ/nociceptin (OFQ/N) system. Results Probl Cell Differ. 2008; 46:1-25. PMID: 18193175.
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    36. Chung S, Funakoshi T, Civelli O. Orphan GPCR research. Br J Pharmacol. 2008 Mar; 153 Suppl 1:S339-46. PMID: 18071299; PMCID: PMC2268047.
    37. Clark SD, Alderson HL, Winn P, Latimer MP, Nothacker HP, Civelli O. Fusion of diphtheria toxin and urotensin II produces a neurotoxin selective for cholinergic neurons in the rat mesopontine tegmentum. J Neurochem. 2007 Jul; 102(1):112-20. PMID: 17419804.
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    38. Dolezelova E, Nothacker HP, Civelli O, Bryant PJ, Zurovec M. A Drosophila adenosine receptor activates cAMP and calcium signaling. Insect Biochem Mol Biol. 2007 Apr; 37(4):318-29. PMID: 17368195.
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    39. Roozendaal B, Lengvilas R, McGaugh JL, Civelli O, Reinscheid RK. Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidation. Learn Mem. 2007 Jan-Feb; 14(1-2):29-35. PMID: 17202427; PMCID: PMC1838543.
    40. Xu YL, Gall CM, Jackson VR, Civelli O, Reinscheid RK. Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brain. J Comp Neurol. 2007 Jan 01; 500(1):84-102. PMID: 17099900.
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    41. Nagasaki H, Wang Z, Jackson VR, Lin S, Nothacker HP, Civelli O. Differential expression of the thyrostimulin subunits, glycoprotein alpha2 and beta5 in the rat pituitary. J Mol Endocrinol. 2006 Aug; 37(1):39-50. PMID: 16901922.
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    42. Jackson VR, Lin SH, Wang Z, Nothacker HP, Civelli O. A study of the rat neuropeptide B/neuropeptide W system using in situ techniques. J Comp Neurol. 2006 Jul 20; 497(3):367-83. PMID: 16736466.
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    43. Chung S, Civelli O. Orphan neuropeptides. Novel neuropeptides modulating sleep or feeding. Neuropeptides. 2006 Aug; 40(4):233-43. PMID: 16814380.
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    44. Jackson VR, Nothacker HP, Civelli O. GPR39 receptor expression in the mouse brain. Neuroreport. 2006 May 29; 17(8):813-6. PMID: 16708020.
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    45. Wang Z, Takahashi T, Saito Y, Nagasaki H, Ly NK, Nothacker HP, Reinscheid RK, Yang J, Chang JK, Shichiri M, Civelli O. Salusin beta is a surrogate ligand of the mas-like G protein-coupled receptor MrgA1. Eur J Pharmacol. 2006 Jun 13; 539(3):145-50. PMID: 16697365.
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    46. Chung S, Pohl S, Zeng J, Civelli O, Reinscheid RK. Endogenous orphanin FQ/nociceptin is involved in the development of morphine tolerance. J Pharmacol Exp Ther. 2006 Jul; 318(1):262-7. PMID: 16595734.
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    47. Okuda-Ashitaka E, Minami T, Matsumura S, Takeshima H, Reinscheid RK, Civelli O, Ito S. The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury. Eur J Neurosci. 2006 Feb; 23(4):995-1004. PMID: 16519664.
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    48. Civelli O, Saito Y, Wang Z, Nothacker HP, Reinscheid RK. Orphan GPCRs and their ligands. Pharmacol Ther. 2006 Jun; 110(3):525-32. PMID: 16289308.
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    49. Civelli O. Orphan GPCRs in the regulation of sleep and circadian rhythm. FEBS J. 2005 Nov; 272(22):5673-4. PMID: 16279932.
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    50. Arai AC, Xia YF, Suzuki E, Kessler M, Civelli O, Nothacker HP. Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cells. J Neurophysiol. 2005 Nov; 94(5):3648-52. PMID: 16222076.
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    51. Clark SD, Nothacker HP, Blaha CD, Tyler CJ, Duangdao DM, Grupke SL, Helton DR, Leonard CS, Civelli O. Urotensin II acts as a modulator of mesopontine cholinergic neurons. Brain Res. 2005 Oct 19; 1059(2):139-48. PMID: 16183039.
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    52. Reinscheid RK, Xu YL, Okamura N, Zeng J, Chung S, Pai R, Wang Z, Civelli O. Pharmacological characterization of human and murine neuropeptide s receptor variants. J Pharmacol Exp Ther. 2005 Dec; 315(3):1338-45. PMID: 16144971.
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    53. Nothacker HP, Wang Z, Zeng H, Mahata SK, O'Connor DT, Civelli O. Proadrenomedullin N-terminal peptide and cortistatin activation of MrgX2 receptor is based on a common structural motif. Eur J Pharmacol. 2005 Sep 05; 519(1-2):191-3. PMID: 16111673.
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    54. Huitron-Resendiz S, Kristensen MP, Sánchez-Alavez M, Clark SD, Grupke SL, Tyler C, Suzuki C, Nothacker HP, Civelli O, Criado JR, Henriksen SJ, Leonard CS, de Lecea L. Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons. J Neurosci. 2005 Jun 08; 25(23):5465-74. PMID: 15944374.
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    55. Reinscheid RK, Xu YL, Civelli O. Neuropeptide S: a new player in the modulation of arousal and anxiety. Mol Interv. 2005 Feb; 5(1):42-6. PMID: 15731503.
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    56. Civelli O. GPCR deorphanizations: the novel, the known and the unexpected transmitters. Trends Pharmacol Sci. 2005 Jan; 26(1):15-9. PMID: 15629200.
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    57. Saito Y, Civelli O. G-protein-coupled receptor deorphanizations. Int Rev Neurobiol. 2005; 65:179-209. PMID: 16140057.
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    58. Civelli O. An orphan receptor adopted by a family of transmitters. Mol Pharmacol. 2005 Mar; 67(3):583-4. PMID: 15604412.
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    59. Xu YL, Jackson VR, Civelli O. Orphan G protein-coupled receptors and obesity. Eur J Pharmacol. 2004 Oct 01; 500(1-3):243-53. PMID: 15464037.
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    60. Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron. 2004 Aug 19; 43(4):487-97. PMID: 15312648.
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    61. Lin SH, Civelli O. Orphan G protein-coupled receptors: targets for new therapeutic interventions. Ann Med. 2004; 36(3):204-14. PMID: 15181976.
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    62. Reinscheid RK, Kim J, Zeng J, Civelli O. High-throughput real-time monitoring of Gs-coupled receptor activation in intact cells using cyclic nucleotide-gated channels. Eur J Pharmacol. 2003 Sep 30; 478(1):27-34. PMID: 14555181.
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    63. Schlumberger SE, Saito Y, Giller T, Hintermann E, Tanner H, Jäggin V, Zumsteg U, Civelli O, Eberle AN. Different structural requirements for melanin-concentrating hormone (MCH) interacting with rat MCH-R1 (SLC-1) and mouse B16 cell MCH-R. J Recept Signal Transduct Res. 2003 Feb; 23(1):69-81. PMID: 12680590.
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    64. Lin SH, Leslie FM, Civelli O. Neurochemical properties of the prolactin releasing peptide (PrRP) receptor expressing neurons: evidence for a role of PrRP as a regulator of stress and nociception. Brain Res. 2002 Oct 11; 952(1):15-30. PMID: 12363400.
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    65. Reinscheid RK, Civelli O. The orphanin FQ/nociceptin knockout mouse: a behavioral model for stress responses. Neuropeptides. 2002 Apr-Jun; 36(2-3):72-6. PMID: 12359498.
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    66. Lin SH, Arai AC, España RA, Berridge CW, Leslie FM, Huguenard JR, Vergnes M, Civelli O. Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures. Neuroscience. 2002; 114(1):229-38. PMID: 12207968.
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    67. Clark SD, Nothacker HP, Wang Z, Saito Y, Leslie FM, Civelli O. The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat. Brain Res. 2001 Dec 27; 923(1-2):120-7. PMID: 11743979.
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    68. Saito Y, Wang Z, Hagino-Yamagishi K, Civelli O, Kawashima S, Maruyama K. Endogenous melanin-concentrating hormone receptor SLC-1 in human melanoma SK-MEL-37 cells. Biochem Biophys Res Commun. 2001 Nov 23; 289(1):44-50. PMID: 11708774.
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    69. Lin SH, Arai AC, Wang Z, Nothacker HP, Civelli O. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. Mol Pharmacol. 2001 Nov; 60(5):916-23. PMID: 11641419.
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    70. Saito Y, Cheng M, Leslie FM, Civelli O. Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. J Comp Neurol. 2001 Jun 18; 435(1):26-40. PMID: 11370009.
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    71. Civelli O, Nothacker HP, Saito Y, Wang Z, Lin SH, Reinscheid RK. Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors. Trends Neurosci. 2001 Apr; 24(4):230-7. PMID: 11250008.
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    72. Nothacker HP, Wang Z, Zhu Y, Reinscheid RK, Lin SH, Civelli O. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000 Dec; 58(6):1601-8. PMID: 11093801.
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    73. Saito Y, Nothacker HP, Civelli O. Melanin-concentrating hormone receptor: an orphan receptor fits the key. Trends Endocrinol Metab. 2000 Oct; 11(8):299-303. PMID: 10996523.
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    74. Reinscheid RK, Nothacker H, Civelli O. The orphanin FQ/nociceptin gene: structure, tissue distribution of expression and functional implications obtained from knockout mice. Peptides. 2000 Jul; 21(7):901-6. PMID: 10998523.
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    75. Civelli O, Reinscheid RK, Nothacker HP. Orphan receptors, novel neuropeptides and reverse pharmaceutical research. Brain Res. 1999 Nov 27; 848(1-2):63-5. PMID: 10612697.
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    76. Neal CR, Mansour A, Reinscheid R, Nothacker HP, Civelli O, Akil H, Watson SJ. Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding. J Comp Neurol. 1999 Oct 04; 412(4):563-605. PMID: 10464356.
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    77. Nothacker HP, Wang Z, McNeill AM, Saito Y, Merten S, O'Dowd B, Duckles SP, Civelli O. Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction. Nat Cell Biol. 1999 Oct; 1(6):383-5. PMID: 10559967.
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    78. Köster A, Montkowski A, Schulz S, Stübe EM, Knaudt K, Jenck F, Moreau JL, Nothacker HP, Civelli O, Reinscheid RK. Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10444-9. PMID: 10468628; PMCID: PMC17908.
    79. Saito Y, Nothacker HP, Wang Z, Lin SH, Leslie F, Civelli O. Molecular characterization of the melanin-concentrating-hormone receptor. Nature. 1999 Jul 15; 400(6741):265-9. PMID: 10421368.
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    80. Neal CR, Mansour A, Reinscheid R, Nothacker HP, Civelli O, Watson SJ. Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat. J Comp Neurol. 1999 Apr 19; 406(4):503-47. PMID: 10205026.
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    81. Civelli O, Nothacker HP. Functional genomics and the discovery of new drug targets. Diabetes Technol Ther. 1999; 1(1):71-6. PMID: 11475307.
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    82. Reinscheid RK, Nothacker HP, Civelli O. Orphan receptors and the concept of reverse physiology: discovery of the novel neuropeptide orphanin FQ/nociceptin. Results Probl Cell Differ. 1999; 26:193-214. PMID: 10453465.
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    83. Civelli O. Functional genomics: the search for novel neurotransmitters and neuropeptides. FEBS Lett. 1998 Jun 23; 430(1-2):55-8. PMID: 9678594.
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    84. Meng F, Ueda Y, Hoversten MT, Taylor LP, Reinscheid RK, Monsma FJ, Watson SJ, Civelli O, Akil H. Creating a functional opioid alkaloid binding site in the orphanin FQ receptor through site-directed mutagenesis. Mol Pharmacol. 1998 Apr; 53(4):772-7. PMID: 9547370.
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    85. Mauger C, Sivan B, Brockhaus M, Fuchs S, Civelli O, Monsma F. Development and characterization of antibodies directed against the mouse D4 dopamine receptor. Eur J Neurosci. 1998 Feb; 10(2):529-37. PMID: 9749715.
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    86. Zenner MT, Nobile M, Henningsen R, Smeraldi E, Civelli O, Hartman DS, Catalano M. Expression and characterization of a dopamine D4R variant associated with delusional disorder. FEBS Lett. 1998 Jan 30; 422(2):146-50. PMID: 9489994.
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    87. Reinscheid RK, Higelin J, Henningsen RA, Monsma FJ, Civelli O. Structures that delineate orphanin FQ and dynorphin A pharmacological selectivities. J Biol Chem. 1998 Jan 16; 273(3):1490-5. PMID: 9430687.
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    88. Civelli O, Nothacker HP, Reinscheid R. Reverse physiology: discovery of the novel neuropeptide, orphanin FQ/nociceptin. Crit Rev Neurobiol. 1998; 12(3):163-76. PMID: 9847053.
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    89. Jenck F, Moreau JL, Martin JR, Kilpatrick GJ, Reinscheid RK, Monsma FJ, Nothacker HP, Civelli O. Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14854-8. PMID: 9405703; PMCID: PMC25127.
    90. Ardati A, Henningsen RA, Higelin J, Reinscheid RK, Civelli O, Monsma FJ. Interaction of [3H]orphanin FQ and 125I-Tyr14-orphanin FQ with the orphanin FQ receptor: kinetics and modulation by cations and guanine nucleotides. Mol Pharmacol. 1997 May; 51(5):816-24. PMID: 9145920.
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    91. Civelli O, Nothacker HP, Bourson A, Ardati A, Monsma F, Reinscheid R. Orphan receptors and their natural ligands. J Recept Signal Transduct Res. 1997 Jan-May; 17(1-3):545-50. PMID: 9029514.
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    93. Devine DP, Taylor L, Reinscheid RK, Monsma FJ, Civelli O, Akil H. Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ. Neurochem Res. 1996 Nov; 21(11):1387-96. PMID: 8947929.
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    94. Knoflach F, Reinscheid RK, Civelli O, Kemp JA. Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons. J Neurosci. 1996 Nov 01; 16(21):6657-64. PMID: 8824306.
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    95. Mogil JS, Grisel JE, Reinscheid RK, Civelli O, Belknap JK, Grandy DK. Orphanin FQ is a functional anti-opioid peptide. Neuroscience. 1996 Nov; 75(2):333-7. PMID: 8930999.
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    96. Nothacker HP, Reinscheid RK, Mansour A, Henningsen RA, Ardati A, Monsma FJ, Watson SJ, Civelli O. Primary structure and tissue distribution of the orphanin FQ precursor. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8677-82. PMID: 8710930; PMCID: PMC38732.
    97. Devine DP, Reinscheid RK, Monsma FJ, Civelli O, Akil H. The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion. Brain Res. 1996 Jul 15; 727(1-2):225-9. PMID: 8842403.
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    98. Reinscheid RK, Ardati A, Monsma FJ, Civelli O. Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J Biol Chem. 1996 Jun 14; 271(24):14163-8. PMID: 8662940.
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    99. Reinscheid RK, Nothacker HP, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJ, Civelli O. Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. Science. 1995 Nov 03; 270(5237):792-4. PMID: 7481766.
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    100. Watts VJ, Lawler CP, Gonzales AJ, Zhou QY, Civelli O, Nichols DE, Mailman RB. Spare receptors and intrinsic activity: studies with D1 dopamine receptor agonists. Synapse. 1995 Oct; 21(2):177-87. PMID: 8584979.
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    101. Bouvier C, Bunzow JR, Guan HC, Unteutsch A, Civelli O, Grandy DK, Van Tol HH. Functional characterization of the human dopamine D4.2 receptor using vaccinia virus as an expression system. Eur J Pharmacol. 1995 Jun 23; 290(1):11-7. PMID: 7664820.
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    102. Civelli O. The neuroreceptors: one key for many locks. J Recept Signal Transduct Res. 1995 Jan-Mar; 15(1-4):161-72. PMID: 8903938.
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    103. Porter TE, Grandy D, Bunzow J, Wiles CD, Civelli O, Frawley LS. Evidence that stimulatory dopamine receptors may be involved in the regulation of prolactin secretion. Endocrinology. 1994 Mar; 134(3):1263-8. PMID: 8119166.
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    104. Hershberger RE, Newman BL, Florio T, Bunzow J, Civelli O, Li XJ, Forte M, Stork PJ. The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in Chinese hamster ovary cells via pertussis toxin-sensitive pathways. Endocrinology. 1994 Mar; 134(3):1277-85. PMID: 7907016.
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    105. Fox CA, Mansour A, Thompson RC, Bunzow JR, Civelli O, Watson SJ. The distribution of dopamine D2 receptor heteronuclear RNA (hnRNA) in the rat brain. J Chem Neuroanat. 1993 Nov-Dec; 6(6):363-73. PMID: 8142073.
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    106. Gelernter J, Kennedy JL, Grandy DK, Zhou QY, Civelli O, Pauls DL, Pakstis A, Kurlan R, Sunahara RK, Niznik HB. Exclusion of close linkage of Tourette's syndrome to D1 dopamine receptor. Am J Psychiatry. 1993 Mar; 150(3):449-53. PMID: 8434661.
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    107. Florio T, Pan MG, Newman B, Hershberger RE, Civelli O, Stork PJ. Dopaminergic inhibition of DNA synthesis in pituitary tumor cells is associated with phosphotyrosine phosphatase activity. J Biol Chem. 1992 Dec 05; 267(34):24169-72. PMID: 1360008.
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    108. Liu YF, Civelli O, Grandy DK, Albert PR. Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C. J Neurochem. 1992 Dec; 59(6):2311-7. PMID: 1331329.
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    109. Liu YF, Civelli O, Zhou QY, Albert PR. Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A. Mol Endocrinol. 1992 Nov; 6(11):1815-24. PMID: 1282671.
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    110. Zhou QY, Li C, Civelli O. Characterization of gene organization and promoter region of the rat dopamine D1 receptor gene. J Neurochem. 1992 Nov; 59(5):1875-83. PMID: 1402930.
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    111. Meador-Woodruff JH, Mansour A, Grandy DK, Damask SP, Civelli O, Watson SJ. Distribution of D5 dopamine receptor mRNA in rat brain. Neurosci Lett. 1992 Oct 12; 145(2):209-12. PMID: 1465219.
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    112. Mansour A, Meng F, Meador-Woodruff JH, Taylor LP, Civelli O, Akil H. Site-directed mutagenesis of the human dopamine D2 receptor. Eur J Pharmacol. 1992 Oct 01; 227(2):205-14. PMID: 1358663.
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    113. Zhou QY, Li C, Olah ME, Johnson RA, Stiles GL, Civelli O. Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7432-6. PMID: 1323836; PMCID: PMC49724.
    114. Grandy DK, Civelli O. G-protein-coupled receptors: the new dopamine receptor subtypes. Curr Opin Neurobiol. 1992 Jun; 2(3):275-81. PMID: 1643409.
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    115. Grandy DK, Leduc R, Makam H, Flanagan T, Diliberto EJ, Civelli O, Viveros OH. Nucleotide and deduced amino acid sequence of bovine adrenal medulla chromogranin B (secretogranin I). Cell Mol Neurobiol. 1992 Apr; 12(2):185-92. PMID: 1350945.
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    116. Civelli O, Bunzow JR, Zhou QY, Grandy DK. The diversity of the dopamine receptors. NIDA Res Monogr. 1992; 126:23-33. PMID: 1491715.
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    117. Jensen S, Plaetke R, Holik J, Hoff M, O'Connell P, Reimherr F, Wender P, Zhou QY, Civelli O, Litt M. Linkage analysis of the D1 dopamine receptor gene and manic depression in six families. Hum Hered. 1992; 42(5):269-75. PMID: 1360940.
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    118. Mansour A, Meador-Woodruff JH, Zhou Q, Civelli O, Akil H, Watson SJ. A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques. Neuroscience. 1992; 46(4):959-71. PMID: 1531866.
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    119. Meador-Woodruff JH, Mansour A, Healy DJ, Kuehn R, Zhou QY, Bunzow JR, Akil H, Civelli O, Watson SJ. Comparison of the distributions of D1 and D2 dopamine receptor mRNAs in rat brain. Neuropsychopharmacology. 1991 Dec; 5(4):231-42. PMID: 1839499.
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    120. Grandy DK, Zhang YA, Bouvier C, Zhou QY, Johnson RA, Allen L, Buck K, Bunzow JR, Salon J, Civelli O. Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes. Proc Natl Acad Sci U S A. 1991 Oct 15; 88(20):9175-9. PMID: 1833775; PMCID: PMC52675.
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    122. Litt M, al-Dhalimy M, Zhou Q, Grandy D, Civelli O. A TaqI RFLP at the DRD1 locus. Nucleic Acids Res. 1991 Jun 11; 19(11):3161. PMID: 1676155; PMCID: PMC328299.
    123. Meador-Woodruff JH, Mansour A, Civelli O, Watson SJ. Distribution of D2 dopamine receptor mRNA in the primate brain. Prog Neuropsychopharmacol Biol Psychiatry. 1991; 15(6):885-93. PMID: 1837159.
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    124. Mansour A, Meador-Woodruff JH, Zhou QY, Civelli O, Akil H, Watson SJ. A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques. Neuroscience. 1991; 45(2):359-71. PMID: 1762683.
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    125. Bates MD, Senogles SE, Bunzow JR, Liggett SB, Civelli O, Caron MG. Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. Mol Pharmacol. 1991 Jan; 39(1):55-63. PMID: 1846220.
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    126. Grandy DK, Zhou QY, Allen L, Litt R, Magenis RE, Civelli O, Litt M. A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP. Am J Hum Genet. 1990 Nov; 47(5):828-34. PMID: 1977312; PMCID: PMC1683700.
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    128. Machida CA, Bunzow JR, Searles RP, Van Tol H, Tester B, Neve KA, Teal P, Nipper V, Civelli O. Molecular cloning and expression of the rat beta 1-adrenergic receptor gene. J Biol Chem. 1990 Aug 05; 265(22):12960-5. PMID: 1695899.
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    129. Mansour A, Meador-Woodruff JH, Bunzow JR, Civelli O, Akil H, Watson SJ. Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis. J Neurosci. 1990 Aug; 10(8):2587-600. PMID: 2143777.
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    130. van Tol HH, Riva M, Civelli O, Creese I. Lack of effect of chronic dopamine receptor blockade on D2 dopamine receptor mRNA level. Neurosci Lett. 1990 Apr 06; 111(3):303-8. PMID: 1970862.
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    131. Albert PR, Zhou QY, Van Tol HH, Bunzow JR, Civelli O. Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene. J Biol Chem. 1990 Apr 05; 265(10):5825-32. PMID: 2156831.
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    132. Meador-Woodruff JH, Mansour A, Bunzow JR, Van Tol HH, Watson SJ, Civelli O. Distribution of D2 dopamine receptor mRNA in rat brain. Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7625-8. PMID: 2529545; PMCID: PMC298119.
    133. Sherman TG, Day R, Civelli O, Douglass J, Herbert E, Akil H, Watson SJ. Regulation of hypothalamic magnocellular neuropeptides and their mRNAs in the Brattleboro rat: coordinate responses to further osmotic challenge. J Neurosci. 1988 Oct; 8(10):3785-96. PMID: 2903913.
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    134. Iadarola MJ, Douglass J, Civelli O, Naranjo JR. Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization. Brain Res. 1988 Jul 12; 455(2):205-12. PMID: 2900057.
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    135. Sivam SP, Takeuchi K, Li S, Douglass J, Civelli O, Calvetta L, Herbert E, McGinty JF, Hong JS. Lithium increases dynorphin A(1-8) and prodynorphin mRNA levels in the basal ganglia of rats. Brain Res. 1988 Apr; 427(2):155-63. PMID: 2898269.
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    136. Douglass J, Cox B, Quinn B, Civelli O, Herbert E. Expression of the prodynorphin gene in male and female mammalian reproductive tissues. Endocrinology. 1987 Feb; 120(2):707-13. PMID: 2879723.
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    137. Khachaturian H, Sherman TG, Lloyd RV, Civelli O, Douglass J, Herbert E, Akil H, Watson SJ. Pro-dynorphin is endogenous to the anterior pituitary and is co-localized with LH and FSH in the gonadotrophs. Endocrinology. 1986 Sep; 119(3):1409-11. PMID: 3089769.
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    138. Civelli O, Douglass J, Rosen H, Martens G, Herbert E. Biosynthesis of opioid peptides. NIDA Res Monogr. 1986; 70:21-42. PMID: 3093878.
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    139. Martens GJ, Civelli O, Herbert E. Nucleotide sequence of cloned cDNA for pro-opiomelanocortin in the amphibian Xenopus laevis. J Biol Chem. 1985 Nov 05; 260(25):13685-9. PMID: 3840481.
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    140. Civelli O, Birnberg N, Comb M, Douglass J, Lissitzky JC, Uhler M, Herbert E. Regulation of opioid gene expression. Peptides. 1983 Sep-Oct; 4(5):651-6. PMID: 6318201.
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    141. Maundrell K, Imaizumi-Scherrer MT, Maxwell ES, Civelli O, Scherrer K. Messenger RNA for the 73,000-dalton poly(A)-binding protein occurs as translationally repressed mRNP in duck reticulocytes. J Biol Chem. 1983 Feb 10; 258(3):1387-90. PMID: 6822518.
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    142. Imaizumi-Scherrer MT, Maundrell K, Civelli O, Scherrer K. Transcriptional and post-transcriptional regulation in duck erythroblasts. Dev Biol. 1982 Sep; 93(1):126-38. PMID: 6127272.
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    143. Vincent A, Goldenberg S, Standart N, Civelli O, Imaizumi-Scherrer T, Maundrell K, Scherrer K. Potential role of mRNP proteins in cytoplasmic control of gene expression in duck erythroblasts. Mol Biol Rep. 1981 May 22; 7(1-3):71-81. PMID: 6114396.
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    144. Vincent A, Civelli O, Maundrell K, Scherrer K. Identification and characterization of the translationally repressed cytoplasmic globin messenger-ribonucleoprotein particles from duck erythroblasts. Eur J Biochem. 1980 Dec; 112(3):617-33. PMID: 7460940.
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    145. Weill JC, Leca G, Vincent A, Civelli O, Pouliquen Y. Messenger RNA for cataractous lens proteins are also present on normal lens polyribosomes. Eur J Biochem. 1980 Oct; 111(2):593-601. PMID: 6161809.
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    146. Civelli O, Vincent A, Maundrell K, Buri JF, Scherrer K. The translational repression of globin mRNA in free cytoplasmic ribonucleoprotein complexes. Eur J Biochem. 1980 Jun; 107(2):577-85. PMID: 7398654.
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    147. Maundrell K, Maxwell ES, Civelli O, Vincent A, Goldenberg S, Buri JF, Imaizumi-Scherrer MT, Scherrer K. Messenger ribonucleoprotein complexes in avian erythroblasts: carriers of post-transcriptional regulation? Mol Biol Rep. 1979 May 31; 5(1-2):43-51. PMID: 379594.
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    148. Goodridge A, Civelli O, Yip C, Scherrer K. Synthesis of albumin and malic enzyme in wheat-germ lysates and Xenopus laevis oocytes programmed with chicken-liver messenger RNA. Eur J Biochem. 1979 May 02; 96(1):1-8. PMID: 456360.
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    149. Vincent A, Civelli O, Buri JF, Scherrer K. Correlation of specific coding sequences with specific proteins associated in untranslated cytoplasmic messenger ribonucleoprotein complexes of duck erythroblasts. FEBS Lett. 1977 May 15; 77(2):281-6. PMID: 862930.
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    150. Vincent A, Civelli O, Buri JF, Scherrer K. Correlation of specific coding sequences with specific proteins associated in untranslated cytoplasmic messenger ribonucleoprotein complexes of duck er. FEBS Lett. 1977 May 15; 77(2):281-286. PMID: 29667196.
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    151. Civelli O, Vincent A, Buri JF, Scherrer K. Evidence for a translational inhibitor linked to globin mRNA in untranslated free cytoplasmic messenger ribonucleoprotein complexes. FEBS Lett. 1976 Dec 15; 72(1):71-6. PMID: 1001473.
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