Shahrdad Lotfipour

Title(s)Associate Professor, Emergency Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-8529
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dynorphinergic lateral hypothalamus to posterior ventral tegmental area pathway matures after adolescence in male rats. Neuropharmacology. 2025 Jun 01; 270:110350. Rogers A, Castro EM, Lotfipour S, Leslie FM. PMID: 39938860.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. "Unraveling the role of CHRNA6, the neuronal α6 nicotinic acetylcholine receptor subunit". Receptors (Basel). 2025 Mar; 4(1). Heydary YH, Castro EM, Lotfipour S, Leslie FM. PMID: 40331132; PMCID: PMC12051391.
      View in: PubMed   Mentions:
    3. Neuroglia in substance use disorders. Handb Clin Neurol. 2025; 210:347-369. Castro EM, Lotfipour S, Leslie FM. PMID: 40148055.
      View in: PubMed   Mentions:    Fields:    
    4. Sub-chronic nicotine exposure influences methamphetamine self-administration and dopamine overflow in a sex-and genotype-dependent manner in humanized CHRNA6 3'-UTR SNP (rs2304297) adolescent rats. Front Pharmacol. 2024; 15:1445303. Carreño D, Facundo A, Cardenas A, Lotfipour S. PMID: 39206256; PMCID: PMC11349519.
      View in: PubMed   Mentions: 1  
    5. Hypersensitivity of the nicotinic acetylcholine receptor subunit (CHRNA2L9'S/L9'S) in female adolescent mice produces deficits in nicotine-induced facilitation of hippocampal-dependent learning and memory. Neurobiol Learn Mem. 2024 09; 213:107959. Wells AC, Mojica C, Lotfipour S. PMID: 38964600.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Dopamine and Norepinephrine Tissue Levels in the Developing Limbic Brain Are Impacted by the Human CHRNA6 3'-UTR Single-Nucleotide Polymorphism (rs2304297) in Rats. Int J Mol Sci. 2024 Mar 26; 25(7). Carreño D, Facundo A, Nguyen MTT, Lotfipour S. PMID: 38612487; PMCID: PMC11011259.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    7. Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits. Adv Drug Alcohol Res. 2023; 3:11628. Wells AC, Lotfipour S. PMID: 38389806; PMCID: PMC10880762.
      View in: PubMed   Mentions: 11  
    8. Male and Female Sprague Dawley Rats Exhibit Equivalent Natural Reward, Nicotine Self-Administration, Extinction, and Reinstatement During Adolescent-Initiated Behaviors. Nicotine Tob Res. 2023 04 06; 25(5):1039-1046. Carreño D, Lotfipour S. PMID: 36208287.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    9. Nicotine on the developing brain. Pharmacol Res. 2023 04; 190:106716. Castro EM, Lotfipour S, Leslie FM. PMID: 36868366; PMCID: PMC10392865.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    10. Sex- and genotype-dependent nicotine plus cue-primed reinstatement is enhanced in adolescent Sprague Dawley rats containing the human CHRNA6 3'-UTR polymorphism (rs2304297). Front Psychiatry. 2022; 13:1064211. Carreño D, Lotfipour S. PMID: 36704741; PMCID: PMC9872558.
      View in: PubMed   Mentions: 3  
    11. Antibiotic Knockdown of Gut Bacteria Sex-Dependently Enhances Intravenous Fentanyl Self-Administration in Adult Sprague Dawley Rats. Int J Mol Sci. 2022 Dec 27; 24(1). Ren M, Lotfipour S. PMID: 36613853; PMCID: PMC9820294.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    12. Age- and Sex-Dependent Nicotine Pretreatment Effects on the Enhancement of Methamphetamine Self-administration in Sprague-Dawley Rats. Nicotine Tob Res. 2022 07 13; 24(8):1186-1192. Cardenas A, Lotfipour S. PMID: 34669941; PMCID: PMC9653006.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    13. Dose- and Sex-Dependent Bidirectional Relationship between Intravenous Fentanyl Self-Administration and Gut Microbiota. Microorganisms. 2022 May 30; 10(6). Ren M, Lotfipour S. PMID: 35744645; PMCID: PMC9229572.
      View in: PubMed   Mentions: 8  
    14. Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adolescent Rats with a Human Polymorphism (rs2304297) in the 3'-UTR of the CHRNA6 Gene. Int J Mol Sci. 2022 Mar 15; 23(6). Cardenas A, Bai Y, Hajy Heydary Y, Li J, Leslie FM, Lotfipour S. PMID: 35328565; PMCID: PMC8948824.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    15. Unique effects of nicotine across the lifespan. Pharmacol Biochem Behav. 2022 03; 214:173343. Ren M, Lotfipour S, Leslie F. PMID: 35122768; PMCID: PMC8904294.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    16. Early adolescent subchronic low-dose nicotine exposure increases subsequent cocaine and fentanyl self-administration in Sprague-Dawley rats. Behav Pharmacol. 2021 02 01; 32(1):86-91. Cardenas A, Martinez M, Saenz Mejia A, Lotfipour S. PMID: 32960853; PMCID: PMC7790845.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    17. The role of the gut microbiome in opioid use. Behav Pharmacol. 2020 04; 31(2&3):113-121. Ren M, Lotfipour S. PMID: 31895059; PMCID: PMC7908675.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    18. Specificity of a rodent alpha(α)6 nicotinic acetylcholine receptor subunit antibody. Psychopharmacology (Berl). 2020 01; 237(1):283-285. Cardenas A, Elabd M, Lotfipour S. PMID: 31786649; PMCID: PMC6954311.
      View in: PubMed   Mentions: 5     Fields:    
    19. Prenatal nicotine sex-dependently alters adolescent dopamine system development. Transl Psychiatry. 2019 11 18; 9(1):304. Dwyer JB, Cardenas A, Franke RM, Chen Y, Bai Y, Belluzzi JD, Lotfipour S, Leslie FM. PMID: 31740669; PMCID: PMC6861272.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    20. Nicotine Gateway Effects on Adolescent Substance Use. West J Emerg Med. 2019 Aug 20; 20(5):696-709. Ren M, Lotfipour S. PMID: 31539325; PMCID: PMC6754186.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    21. Maternal nicotine exposure effects on adolescent learning and memory are abolished in alpha(α)2* nicotinic acetylcholine receptor-null mutant mice. Neuropharmacology. 2018 06; 135:529-535. Mojica C, Bai Y, Lotfipour S. PMID: 29677582.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsPHPublic Health
    22. Morphine hyposensitivity in streptozotocin-diabetic rats: Reversal by dietary l-arginine treatment. Clin Exp Pharmacol Physiol. 2018 Jan; 45(1):42-49. Lotfipour S, Smith MT. PMID: 28925511.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    23. Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations. Sci Rep. 2017 05 24; 7(1):2333. Hersman S, Cushman J, Lemelson N, Wassum K, Lotfipour S, Fanselow MS. PMID: 28539613; PMCID: PMC5443779.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    24. α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice. Learn Mem. 2017 06; 24(6):231-244. Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J. PMID: 28507032; PMCID: PMC5435881.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects. Neuropsychopharmacology. 2017 Jul; 42(8):1610-1618. Faulkner P, Ghahremani DG, Tyndale RF, Cox CM, Kazanjian AS, Paterson N, Lotfipour S, Hellemann GS, Petersen N, Vigil C, London ED. PMID: 28117337; PMCID: PMC5518898.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    26. Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse. Am J Drug Alcohol Abuse. 2017 03; 43(2):171-185. Cross SJ, Lotfipour S, Leslie FM. PMID: 27532746; PMCID: PMC5493323.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    27. α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression. Biochem Pharmacol. 2015 Oct 15; 97(4):558-565. Upton M, Lotfipour S. PMID: 26111579; PMCID: PMC4607355.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    28. Maternal cigarette smoking during pregnancy predicts drug use via externalizing behavior in two community-based samples of adolescents. Addiction. 2014 Oct; 109(10):1718-29. Lotfipour S, Ferguson E, Leonard G, Miettunen J, Perron M, Pike GB, Richer L, Séguin JR, Veillette S, Jarvelin MR, Moilanen I, Mäki P, Nordström T, Pausova Z, Veijola J, Paus T. PMID: 24942256.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    29. Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors. J Neurosci. 2013 May 01; 33(18):7728-41. Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J. PMID: 23637165; PMCID: PMC3831006.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    30. A single administration of low-dose varenicline saturates α4β2* nicotinic acetylcholine receptors in the human brain. Neuropsychopharmacology. 2012 Jun; 37(7):1738-48. Lotfipour S, Mandelkern M, Alvarez-Estrada M, Brody AL. PMID: 22395733; PMCID: PMC3358744.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    31. Quantitative Molecular Imaging of Neuronal Nicotinic Acetylcholine Receptors in the Human Brain with A-85380 Radiotracers. Curr Med Imaging Rev. 2011 May 01; 7(2):107-112. Lotfipour S, Mandelkern M, Brody AL. PMID: 22773924; PMCID: PMC3389797.
      View in: PubMed   Mentions: 6     Fields:    
    32. The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition. Neuropharmacology. 2011 Jul-Aug; 61(1-2):95-104. Lotfipour S, Arnold MM, Hogenkamp DJ, Gee KW, Belluzzi JD, Leslie FM. PMID: 21419142; PMCID: PMC3105177.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    33. Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring. Am J Med Genet B Neuropsychiatr Genet. 2010 Oct 05; 153B(7):1350-4. Toledo-Rodriguez M, Lotfipour S, Leonard G, Perron M, Richer L, Veillette S, Pausova Z, Paus T. PMID: 20583129.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCellsPHPublic Health
    34. Orbitofrontal cortex and drug use during adolescence: role of prenatal exposure to maternal smoking and BDNF genotype. Arch Gen Psychiatry. 2009 Nov; 66(11):1244-52. Lotfipour S, Ferguson E, Leonard G, Perron M, Pike B, Richer L, Séguin JR, Toro R, Veillette S, Pausova Z, Paus T. PMID: 19884612.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansPHPublic Health
    35. Involvement of alpha1-adrenergic receptors in tranylcypromine enhancement of nicotine self-administration in rat. Psychopharmacology (Berl). 2007 Sep; 193(4):457-65. Villégier AS, Lotfipour S, Belluzzi JD, Leslie FM. PMID: 17486319.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    36. Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain. 2007 Dec 05; 132(3):289-300. Nielsen CK, Ross FB, Lotfipour S, Saini KS, Edwards SR, Smith MT. PMID: 17467904.
      View in: PubMed   Mentions: 66     Fields:    Translation:Animals
    37. Tranylcypromine enhancement of nicotine self-administration. Neuropharmacology. 2007 May; 52(6):1415-25. Villégier AS, Lotfipour S, McQuown SC, Belluzzi JD, Leslie FM. PMID: 17412372.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    38. Adolescent maturation of cocaine-sensitive neural mechanisms. Neuropsychopharmacology. 2007 Nov; 32(11):2279-89. Cao J, Lotfipour S, Loughlin SE, Leslie FM. PMID: 17299504.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    39. Adolescent development of forebrain stimulant responsiveness: insights from animal studies. Ann N Y Acad Sci. 2004 Jun; 1021:148-59. Leslie FM, Loughlin SE, Wang R, Perez L, Lotfipour S, Belluzzia JD. PMID: 15251884.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
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