Wen-Hwa Lee

Title(s)Professor Emeritus, Biological Chemistry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-4492
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Helicase SUV3, polynucleotide phosphorylase, and mitochondrial polyadenylation polymerase form a transient complex to modulate mitochondrial mRNA polyadenylated tail lengths in response to energetic changes. J Biol Chem. 2014 Jun 13; 289(24):16727-35. Wang DD, Guo XE, Modrek AS, Chen CF, Chen PL, Lee WH. PMID: 24770417; PMCID: PMC4059117.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    2. Complementary interhelical interactions between three buried Glu-Lys pairs within three heptad repeats are essential for Hec1-Nuf2 heterodimerization and mitotic progression. J Biol Chem. 2013 Nov 29; 288(48):34403-13. Ngo B, Hu CM, Guo XE, Ngo B, Wei R, Zhu J, Lee WH. PMID: 24129578; PMCID: PMC3843055.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med. 2013 Mar; 5(3):353-65. Zhu J, Zhou L, Wu G, Konig H, Lin X, Li G, Qiu XL, Chen CF, Hu CM, Goldblatt E, Bhatia R, Chamberlin AR, Chen PL, Lee WH. PMID: 23341130; PMCID: PMC3598077.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    4. Uncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation. J Biol Chem. 2011 Nov 04; 286(44):38783-38794. Guo XE, Chen CF, Wang DD, Modrek AS, Phan VH, Lee WH, Chen PL. PMID: 21911497; PMCID: PMC3207411.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    5. Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint. Mol Biol Cell. 2011 Oct; 22(19):3584-94. Wei R, Ngo B, Wu G, Lee WH. PMID: 21832156; PMCID: PMC3183014.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    6. Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly. J Biol Chem. 2011 Aug 26; 286(34):30097-106. Tsai CY, Ngo B, Tapadia A, Hsu PH, Wu G, Lee WH. PMID: 21705324; PMCID: PMC3191049.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    7. IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells. Sci Transl Med. 2011 Apr 13; 3(78):78ra31. Furuta S, Jeng YM, Zhou L, Huang L, Kuhn I, Bissell MJ, Lee WH. PMID: 21490275; PMCID: PMC3199022.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    8. From bench to bedside: the growing use of translational research in cancer medicine. Am J Transl Res. 2010 Jan 01; 2(1):1-18. Goldblatt EM, Lee WH. PMID: 20182579; PMCID: PMC2826819.
      View in: PubMed   Mentions: 26  
    9. Derepression of HMGA2 via removal of ZBRK1/BRCA1/CtIP complex enhances mammary tumorigenesis. J Biol Chem. 2010 Feb 12; 285(7):4464-71. Ahmed KM, Tsai CY, Lee WH. PMID: 20007691; PMCID: PMC2836052.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    10. Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1. Mol Biol Cell. 2009 Nov; 20(22):4686-95. Wu G, Wei R, Cheng E, Ngo B, Lee WH. PMID: 19776357; PMCID: PMC2777099.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    11. The launch of the american journal of translational research. Am J Transl Res. 2009 Sep 01; 1(1):i. Lee WH, Hung MC, Iczkowski KA, Languino LR, Dubinett SM, Wang D. PMID: 19966932; PMCID: PMC2776285.
      View in: PubMed   Mentions: 1  
    12. Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality. J Biol Chem. 2009 Jul 31; 284(31):20812-21. Wang DD, Shu Z, Lieser SA, Chen PL, Lee WH. PMID: 19509288; PMCID: PMC2742846.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    13. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J Med Chem. 2009 Mar 26; 52(6):1757-67. Qiu XL, Li G, Wu G, Zhu J, Zhou L, Chen PL, Chamberlin AR, Lee WH. PMID: 19243176; PMCID: PMC2670097.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    14. Stereoselective synthesis of chiral IBR2 analogues. J Org Chem. 2009 Mar 06; 74(5):2018-27. Qiu XL, Zhu J, Wu G, Lee WH, Chamberlin AR. PMID: 19191556.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    15. Translational medical research: present and future. Am J Transl Res. 2009 Jan 25; 1(2):99-100. Lee WH. PMID: 19956423; PMCID: PMC2776310.
      View in: PubMed   Mentions:
    16. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 2008 Oct 15; 68(20):8393-9. Wu G, Qiu XL, Zhou L, Zhu J, Chamberlin R, Lau J, Chen PL, Lee WH. PMID: 18922912; PMCID: PMC2709694.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    17. Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells. J Biol Chem. 2008 Oct 03; 283(40):27064-73. Khidr L, Wu G, Davila A, Procaccio V, Wallace D, Lee WH. PMID: 18678873; PMCID: PMC2556002.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    18. Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells. Mol Cell Biol. 2008 Jun; 28(11):3652-62. Wu G, Lin YT, Wei R, Chen Y, Shan Z, Lee WH. PMID: 18362163; PMCID: PMC2423303.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    19. RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival. Mol Cell Biol. 2007 Jul; 27(13):4905-16. Lin X, Liu CC, Gao Q, Zhang X, Wu G, Lee WH. PMID: 17470549; PMCID: PMC1951495.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    20. Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science. 2006 Dec 01; 314(5804):1467-70. Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY. PMID: 17138902.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    21. CtIP, a multivalent adaptor connecting transcriptional regulation, checkpoint control and tumor suppression. Cell Cycle. 2006 Aug; 5(15):1592-6. Wu G, Lee WH. PMID: 16880746.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    22. Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell. 2006 Jul; 10(1):13-24. Furuta S, Wang JM, Wei S, Jeng YM, Jiang X, Gu B, Chen PL, Lee EY, Lee WH. PMID: 16843262.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    23. CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression. Mol Cell Biol. 2006 Apr; 26(8):3124-34. Liu F, Lee WH. PMID: 16581787; PMCID: PMC1446954.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    24. Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9176-81. Furuta S, Jiang X, Gu B, Cheng E, Chen PL, Lee WH. PMID: 15967981; PMCID: PMC1166629.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    25. Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol Cell Biol. 2005 May; 25(9):3535-42. Chen PL, Liu F, Cai S, Lin X, Li A, Chen Y, Gu B, Lee EY, Lee WH. PMID: 15831459; PMCID: PMC1084307.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    26. Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. J Biol Chem. 2004 Oct 15; 279(42):43522-9. Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH. PMID: 15294905.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    27. The DNA double-strand break response pathway: becoming more BRCAish than ever. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):935-44. Ting NS, Lee WH. PMID: 15279779.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    28. Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res. 2004 May 15; 64(10):3525-32. Lin SC, Lee KF, Nikitin AY, Hilsenbeck SG, Cardiff RD, Li A, Kang KW, Frank SA, Lee WH, Lee EY. PMID: 15150107.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    29. Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change. Biochemistry. 2004 Apr 27; 43(16):4781-90. Shu Z, Vijayakumar S, Chen CF, Chen PL, Lee WH. PMID: 15096047.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
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