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Chen, Dongbao

Title(s)Professor, Obstetrics and Gynecology
Phone(949) 824-2739
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    Collapse Biography 
    Collapse Education and Training
    China Agricultural University, Beijing, ChinaPhD07/01/1Reproductive Physiology

    Collapse Research 
    Collapse Research Activities and Funding
    Pregnancy-Dependent Protein Sulfyhydration in Human Uterine Artery
    NIH/NICHD R21HD097498Aug 1, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Quantitative proteomics analysis of VEGF responsive endothelial protein S-nitrosylation
    NIH/NICHD R03HD084972Jul 5, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Estrogen and Endothelial Protein Nitrosylation
    NIH/NHLBI R21HL098746Aug 1, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Caveolin-1, Caveolae and Placental Angiogenesis
    NIH/NHLBI R01HL074947Jul 1, 2004 - May 31, 2010
    Role: Principal Investigator
    Actions of Estrogen on Uterine Artery Endothelium
    NIH/NHLBI R01HL070562Sep 25, 2001 - Mar 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lechuga TJ, Qi QR, Magness RR, Chen DB. Ovine uterine artery hydrogen sulfide biosynthesis in vivo: effects of ovarian cycle and pregnancy†. Biol Reprod. 2019 Jun 01; 100(6):1630-1636. PMID: 30772913.
      View in: PubMed
    2. Lechuga TJ, Qi QR, Kim T, Magness RR, Chen DB. E2ß stimulates ovine uterine artery endothelial cell H2S production in vitro by estrogen receptor-dependent upregulation of cystathionine ß-synthase and cystathionine ?-lyase expression†. Biol Reprod. 2019 Feb 01; 100(2):514-522. PMID: 30277497.
      View in: PubMed
    3. Pastore MB, Landeros RV, Chen DB, Magness RR. Structural analysis of estrogen receptors: interaction between estrogen receptors and cav-1 within the caveolae†. Biol Reprod. 2019 Feb 01; 100(2):495-504. PMID: 30137221.
      View in: PubMed
    4. Lechuga TJ, Chen DB. Analysis of Vascular Hydrogen Sulfide Biosynthesis. Methods Mol Biol. 2019; 2007:19-36. PMID: 31148104.
      View in: PubMed
    5. Lechuga TJ, Bilg AK, Patel BA, Nguyen NA, Qi QR, Chen DB. Estradiol-17ß stimulates H2 S biosynthesis by ER-dependent CBS and CSE transcription in uterine artery smooth muscle cells in vitro. J Cell Physiol. 2019 Jun; 234(6):9264-9273. PMID: 30317617.
      View in: PubMed
    6. Yin R, Rice SJ, Wang J, Gao L, Tsai J, Anvari RT, Zhou F, Liu X, Wang G, Tang Y, Mihm MC, Belani CP, Chen DB, Nelson JS, Tan W. Membrane trafficking and exocytosis are upregulated in port wine stain blood vessels. Histol Histopathol. 2019 May; 34(5):479-490. PMID: 30302745.
      View in: PubMed
    7. Lei J, Nie Q, Chen DB. A single-cell epigenetic model for paternal psychological stress-induced transgenerational reprogramming in offspring. Biol Reprod. 2018 06 01; 98(6):846-855. PMID: 29506130.
      View in: PubMed
    8. Zhu XX, Yan YW, Chen D, Ai CZ, Lu X, Xu SS, Jiang S, Zhong GS, Chen DB, Jiang YZ. Correction: Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells. Oncotarget. 2018 04 03; 9(25):17978. PMID: 29707162.
      View in: PubMed
    9. Chen DB, Feng L, Hodges JK, Lechuga TJ, Zhang H. Human trophoblast-derived hydrogen sulfide stimulates placental artery endothelial cell angiogenesis. Biol Reprod. 2017 Sep 01; 97(3):478-489. PMID: 29024947.
      View in: PubMed
    10. Zhang HH, Chen JC, Sheibani L, Lechuga TJ, Chen DB. Pregnancy Augments VEGF-Stimulated In Vitro Angiogenesis and Vasodilator (NO and H2S) Production in Human Uterine Artery Endothelial Cells. J Clin Endocrinol Metab. 2017 07 01; 102(7):2382-2393. PMID: 28398541.
      View in: PubMed
    11. Sheibani L, Lechuga TJ, Zhang H, Hameed A, Wing DA, Kumar S, Rosenfeld CR, Chen DB. Augmented H2S production via cystathionine-beta-synthase upregulation plays a role in pregnancy-associated uterine vasodilation. Biol Reprod. 2017 03 01; 96(3):664-672. PMID: 28339573.
      View in: PubMed
    12. Zhu XX, Yan YW, Chen D, Ai CZ, Lu X, Xu SS, Jiang S, Zhong GS, Chen DB, Jiang YZ. Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells. Oncotarget. 2016 Sep 27; 7(39):63561-63570. PMID: 27566578.
      View in: PubMed
    13. Zhang HH, Lechuga TJ, Chen Y, Yang Y, Huang L, Chen DB. Quantitative Proteomics Analysis of VEGF-Responsive Endothelial Protein S-Nitrosylation Using Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and LC-MS/MS. Biol Reprod. 2016 05; 94(5):114. PMID: 27075618.
      View in: PubMed
    14. Tan K, An L, Miao K, Ren L, Hou Z, Tao L, Zhang Z, Wang X, Xia W, Liu J, Wang Z, Xi G, Gao S, Sui L, Zhu DS, Wang S, Wu Z, Bach I, Chen DB, Tian J. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3197-202. PMID: 26951653.
      View in: PubMed
    15. Lechuga TJ, Zhang HH, Sheibani L, Karim M, Jia J, Magness RR, Rosenfeld CR, Chen DB. Estrogen Replacement Therapy in Ovariectomized Nonpregnant Ewes Stimulates Uterine Artery Hydrogen Sulfide Biosynthesis by Selectively Up-Regulating Cystathionine ß-Synthase Expression. Endocrinology. 2015 Jun; 156(6):2288-98. PMID: 25825818.
      View in: PubMed
    16. Zhang HH, Wang W, Feng L, Yang Y, Zheng J, Huang L, Chen DB. S-nitrosylation of Cofilin-1 Serves as a Novel Pathway for VEGF-Stimulated Endothelial Cell Migration. J Cell Physiol. 2015 Feb; 230(2):406-17. PMID: 25056928.
      View in: PubMed
    17. Zhang HH, Lechuga TJ, Tith T, Wang W, Wing DA, Chen DB. S-nitrosylation of cofilin-1 mediates estradiol-17ß-stimulated endothelial cytoskeleton remodeling. Mol Endocrinol. 2015 Mar; 29(3):434-44. PMID: 25635941.
      View in: PubMed
    18. Satohisa S, Zhang HH, Feng L, Yang YY, Huang L, Chen DB. Endogenous NO upon estradiol-17ß stimulation and NO donor differentially regulate mitochondrial S-nitrosylation in endothelial cells. Endocrinology. 2014 Aug; 155(8):3005-16. PMID: 24877627.
      View in: PubMed
    19. Jiang YZ, Li Y, Wang K, Dai CF, Huang SA, Chen DB, Zheng J. Distinct roles of HIF1A in endothelial adaptations to physiological and ambient oxygen. Mol Cell Endocrinol. 2014 Jun 25; 391(1-2):60-7. PMID: 24796659.
      View in: PubMed
    20. Chen DB, Zheng J. Regulation of placental angiogenesis. Microcirculation. 2014 Jan; 21(1):15-25. PMID: 23981199.
      View in: PubMed
    21. Jiang YZ, Wang K, Li Y, Dai CF, Wang P, Kendziorski C, Chen DB, Zheng J. Enhanced cellular responses and distinct gene profiles in human fetoplacental artery endothelial cells under chronic low oxygen. Biol Reprod. 2013 Dec; 89(6):133. PMID: 24152727.
      View in: PubMed
    22. Chen DB, Wang W. Human placental microRNAs and preeclampsia. Biol Reprod. 2013 May; 88(5):130. PMID: 23575145.
      View in: PubMed
    23. Jiang YZ, Wang K, Li Y, Dai CF, Wang P, Kendziorski C, Chen DB, Zheng J. Transcriptional and functional adaptations of human endothelial cells to physiological chronic low oxygen. Biol Reprod. 2013 May; 88(5):114. PMID: 23536375.
      View in: PubMed
    24. Ehsanipoor RM, Fortson W, Fitzmaurice LE, Liao WX, Wing DA, Chen DB, Chan K. Nitric oxide and carbon monoxide production and metabolism in preeclampsia. Reprod Sci. 2013 May; 20(5):542-8. PMID: 23012314.
      View in: PubMed
    25. Feng L, Zhang HH, Wang W, Zheng J, Chen DB. Compartmentalizing proximal FGFR1 signaling in ovine placental artery endothelial cell caveolae. Biol Reprod. 2012 Aug; 87(2):40. PMID: 22674390.
      View in: PubMed
    26. Feng L, Liao WX, Luo Q, Zhang HH, Wang W, Zheng J, Chen DB. Caveolin-1 orchestrates fibroblast growth factor 2 signaling control of angiogenesis in placental artery endothelial cell caveolae. J Cell Physiol. 2012 Jun; 227(6):2480-91. PMID: 21830216.
      View in: PubMed
    27. Liao WX, Laurent LC, Agent S, Hodges J, Chen DB. Human placental expression of SLIT/ROBO signaling cues: effects of preeclampsia and hypoxia. Biol Reprod. 2012 Apr; 86(4):111. PMID: 22262697.
      View in: PubMed
    28. Ramadoss J, Liao WX, Morschauser TJ, Lopez GE, Patankar MS, Chen DB, Magness RR. Endothelial caveolar hub regulation of adenosine triphosphate-induced endothelial nitric oxide synthase subcellular partitioning and domain-specific phosphorylation. Hypertension. 2012 May; 59(5):1052-9. PMID: 22454479.
      View in: PubMed
    29. Wang W, Feng L, Zhang H, Hachy S, Satohisa S, Laurent LC, Parast M, Zheng J, Chen DB. Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta. J Clin Endocrinol Metab. 2012 Jun; 97(6):E1051-9. PMID: 22438230.
      View in: PubMed
    30. Zhang HH, Feng L, Wang W, Magness RR, Chen DB. Estrogen-responsive nitroso-proteome in uterine artery endothelial cells: role of endothelial nitric oxide synthase and estrogen receptor-ß. J Cell Physiol. 2012 Jan; 227(1):146-59. PMID: 21374595.
      View in: PubMed
    31. Zhang HH, Wang YP, Chen DB. Analysis of nitroso-proteomes in normotensive and severe preeclamptic human placentas. Biol Reprod. 2011 May; 84(5):966-75. PMID: 21228217.
      View in: PubMed
    32. Li SM, Zeng LW, Feng L, Chen DB. Rac1-dependent intracellular superoxide formation mediates vascular endothelial growth factor-induced placental angiogenesis in vitro. Endocrinology. 2010 Nov; 151(11):5315-25. PMID: 20844008.
      View in: PubMed
    33. Liao WX, Wing DA, Geng JG, Chen DB. Perspectives of SLIT/ROBO signaling in placental angiogenesis. Histol Histopathol. 2010 09; 25(9):1181-90. PMID: 20607660.
      View in: PubMed
    34. Zhang HH, Feng L, Livnat I, Hoh JK, Shim JY, Liao WX, Chen DB. Estradiol-17beta stimulates specific receptor and endogenous nitric oxide-dependent dynamic endothelial protein S-nitrosylation: analysis of endothelial nitrosyl-proteome. Endocrinology. 2010 Aug; 151(8):3874-87. PMID: 20519370.
      View in: PubMed
    35. Liao WX, Feng L, Zheng J, Chen DB. Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factor. Endocrinology. 2010 Jul; 151(7):3432-44. PMID: 20463056.
      View in: PubMed
    36. Mata-Greenwood E, Liao WX, Wang W, Zheng J, Chen DB. Activation of AP-1 transcription factors differentiates FGF2 and vascular endothelial growth factor regulation of endothelial nitric-oxide synthase expression in placental artery endothelial cells. J Biol Chem. 2010 Jun 04; 285(23):17348-58. PMID: 20371606.
      View in: PubMed
    37. Ramadoss J, Liao WX, Chen DB, Magness RR. High-throughput caveolar proteomic signature profile for maternal binge alcohol consumption. Alcohol. 2010 Nov-Dec; 44(7-8):691-7. PMID: 20053519.
      View in: PubMed
    38. Liao WX, Feng L, Zhang H, Zheng J, Moore TR, Chen DB. Compartmentalizing VEGF-induced ERK2/1 signaling in placental artery endothelial cell caveolae: a paradoxical role of caveolin-1 in placental angiogenesis in vitro. Mol Endocrinol. 2009 Sep; 23(9):1428-44. PMID: 19477952.
      View in: PubMed
    39. Cheng WM, An L, Wu ZH, Zhu YB, Liu JH, Gao HM, Li XH, Zheng SJ, Chen DB, Tian JH. Effects of disulfide bond reducing agents on sperm chromatin structural integrity and developmental competence of in vitro matured oocytes after intracytoplasmic sperm injection in pigs. Reproduction. 2009 Apr; 137(4):633-43. PMID: 19155332.
      View in: PubMed
    40. Mata-Greenwood E, Liao WX, Zheng J, Chen DB. Differential activation of multiple signalling pathways dictates eNOS upregulation by FGF2 but not VEGF in placental artery endothelial cells. Placenta. 2008 Aug; 29(8):708-17. PMID: 18571718.
      View in: PubMed
    41. Wang K, Song Y, Chen DB, Zheng J. Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial cells. Biol Reprod. 2008 Oct; 79(4):704-10. PMID: 18509162.
      View in: PubMed
    42. Smith A, Contreras C, Ko KH, Chow J, Dong X, Tuo B, Zhang HH, Chen DB, Dong H. Gender-specific protection of estrogen against gastric acid-induced duodenal injury: stimulation of duodenal mucosal bicarbonate secretion. Endocrinology. 2008 Sep; 149(9):4554-66. PMID: 18499763.
      View in: PubMed
    43. Mata-Greenwood E, Chen DB. Racial differences in nitric oxide-dependent vasorelaxation. Reprod Sci. 2008 Jan; 15(1):9-25. PMID: 18212350.
      View in: PubMed
    44. Hou X, Arvisais EW, Jiang C, Chen DB, Roy SK, Pate JL, Hansen TR, Rueda BR, Davis JS. Prostaglandin F2alpha stimulates the expression and secretion of transforming growth factor B1 via induction of the early growth response 1 gene (EGR1) in the bovine corpus luteum. Mol Endocrinol. 2008 Feb; 22(2):403-14. PMID: 17916653.
      View in: PubMed
    45. Zheng J, Wen Y, Song Y, Wang K, Chen DB, Magness RR. Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation. Biol Reprod. 2008 Jan; 78(1):143-50. PMID: 17901071.
      View in: PubMed
    46. Qian XX, Mata-Greenwood E, Liao WX, Zhang H, Zheng J, Chen DB. Transcriptional regulation of endothelial nitric oxide synthase expression in uterine artery endothelial cells by c-Jun/AP-1. Mol Cell Endocrinol. 2007 Dec 15; 279(1-2):39-51. PMID: 17933457.
      View in: PubMed
    47. Chen DB, Jia S, King AG, Barker A, Li SM, Mata-Greenwood E, Zheng J, Magness RR. Global protein expression profiling underlines reciprocal regulation of caveolin 1 and endothelial nitric oxide synthase expression in ovariectomized sheep uterine artery by estrogen/progesterone replacement therapy. Biol Reprod. 2006 May; 74(5):832-8. PMID: 16436525.
      View in: PubMed
    48. Zheng J, Wen Y, Austin JL, Chen DB. Exogenous nitric oxide stimulates cell proliferation via activation of a mitogen-activated protein kinase pathway in ovine fetoplacental artery endothelial cells. Biol Reprod. 2006 Feb; 74(2):375-82. PMID: 16251502.
      View in: PubMed
    49. Chen DB, Li SM, Qian XX, Moon C, Zheng J. Tyrosine phosphorylation of caveolin 1 by oxidative stress is reversible and dependent on the c-src tyrosine kinase but not mitogen-activated protein kinase pathways in placental artery endothelial cells. Biol Reprod. 2005 Oct; 73(4):761-72. PMID: 15958730.
      View in: PubMed
    50. Zheng J, Bird IM, Chen DB, Magness RR. Angiotensin II regulation of ovine fetoplacental artery endothelial functions: interactions with nitric oxide. J Physiol. 2005 May 15; 565(Pt 1):59-69. PMID: 15790666.
      View in: PubMed
    51. Byers MJ, Zangl A, Phernetton TM, Lopez G, Chen DB, Magness RR. Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ERalpha and ERbeta levels. J Physiol. 2005 May 15; 565(Pt 1):85-99. PMID: 15774511.
      View in: PubMed
    52. Magness RR, Phernetton TM, Gibson TC, Chen DB. Uterine blood flow responses to ICI 182 780 in ovariectomized oestradiol-17beta-treated, intact follicular and pregnant sheep. J Physiol. 2005 May 15; 565(Pt 1):71-83. PMID: 15774510.
      View in: PubMed
    53. Zheng J, Wen Y, Chen DB, Bird IM, Magness RR. Angiotensin II elevates nitric oxide synthase 3 expression and nitric oxide production via a mitogen-activated protein kinase cascade in ovine fetoplacental artery endothelial cells. Biol Reprod. 2005 Jun; 72(6):1421-8. PMID: 15728793.
      View in: PubMed
    54. Liao WX, Magness RR, Chen DB. Expression of estrogen receptors-alpha and -beta in the pregnant ovine uterine artery endothelial cells in vivo and in vitro. Biol Reprod. 2005 Mar; 72(3):530-7. PMID: 15564597.
      View in: PubMed
    55. Chen DB, Bird IM, Zheng J, Magness RR. Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells. Endocrinology. 2004 Jan; 145(1):113-25. PMID: 14512434.
      View in: PubMed
    56. Chen DB, Davis JS. Epidermal growth factor induces c-fos and c-jun mRNA via Raf-1/MEK1/ERK-dependent and -independent pathways in bovine luteal cells. Mol Cell Endocrinol. 2003 Feb 28; 200(1-2):141-54. PMID: 12644307.
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