Dongbao Chen

Title(s)Professor, Obstetrics and Gynecology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-2739
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    Collapse Biography 
    Collapse Education and Training
    China Agricultural University, Beijing, ChinaPhD1991Reproductive Physiology
    Baylor College of Medicine, Houston, TXPostdoc1995Reproductive Physiology
    University of Kansas School of Medicine, Wichita, KSPostdoc1998Molecular Endocrinology

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Actions of Estrogen on Uterine Artery Endothelium
    NIH R01HL070562Jun 1, 2022 - May 31, 2026
    Role: Principal Investigator
    H2S and Uterine Vasodilation in Pregnancy and Preeclampsia
    NIH R01HD105699Jul 20, 2021 - Jun 30, 2026
    Role: Principal Investigator
    H2S and Endometrial Angiogenesis
    NIH R03HD102451Aug 1, 2020 - Jul 31, 2022
    Role: Principal Investigator
    Pregnancy-Dependent Protein Sulfyhydration in Human Uterine Artery
    NIH R21HD097498Aug 1, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Vascular Pathogenesis of Port Wine Stain
    NIH R01AR073172Apr 16, 2018 - Mar 31, 2023
    Role: Co-Investigator
    Quantitative proteomics analysis of VEGF responsive endothelial protein S-nitrosylation
    NIH R03HD084972Jul 5, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Estrogen and Endothelial Protein Nitrosylation
    NIH R21HL098746Aug 1, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Cellular Mechanisms of Amniotic Fluid Volume Regulation
    NIH R01HD061541Jul 1, 2010 - May 31, 2016
    Role: Co-Investigator
    Caveolin-1, Caveolae and Placental Angiogenesis
    NIH R01HL074947Jul 1, 2004 - May 31, 2010
    Role: Principal Investigator
    Actions of Estrogen on Uterine Artery Endothelium
    NIH R01HL070562Sep 25, 2001 - Mar 31, 2021
    Role: Principal Investigator
    NIH R01HL064601Feb 1, 2001 - Jan 31, 2005
    Role: Co-Investigator
    Effects of Nitric Oxide on Fetoplacental Angiogenesis
    NIH R01HL064703Sep 1, 2000 - May 31, 2010
    Role: Co-Investigator
    Hypoxia Effects on Amniotic Fluid Volume
    NIH R01HD035890Jul 1, 1998 - Jun 30, 2010
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark. Br J Dermatol. 2023 11 16; 189(6):780-783. Nguyen V, Gao C, Hochman ML, Kravitz J, Chen EH, Friedman HI, Wenceslau CF, Chen D, Wang Y, Nelson JS, Jegga AG, Tan W. PMID: 37672656; PMCID: PMC10653332.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. ICI 182,780 Attenuates Selective Upregulation of Uterine Artery Cystathionine β-Synthase Expression in Rat Pregnancy. Int J Mol Sci. 2023 Sep 21; 24(18). Bai J, Li Y, Yan G, Zhou J, Salmeron AG, Fategbe OT, Kumar S, Chen X, Chen DB. PMID: 37762687; PMCID: PMC10532247.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells. Metabolites. 2023 Aug 31; 13(9). Nguyen V, Kravitz J, Gao C, Hochman ML, Meng D, Chen D, Wang Y, Jegga AG, Nelson JS, Tan W. PMID: 37755263; PMCID: PMC10537749.
      View in: PubMed   Mentions:
    4. Supporting materials: Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark. bioRxiv. 2023 Aug 24. Nguyen V, Gao C, Hochman ML, Kravitz J, Chen EH, Friedman HI, Wenceslau CF, Chen D, Wang Y, Nelson JS, Jegga AG, Tan W. PMID: 37662218; PMCID: PMC10473620.
      View in: PubMed   Mentions:
    5. Mapping Pregnancy-dependent Sulfhydrome Unfolds Diverse Functions of Protein Sulfhydration in Human Uterine Artery. Endocrinology. 2023 08 01; 164(9). Bai J, Jiao F, Salmeron AG, Xu S, Xian M, Huang L, Chen DB. PMID: 37439247; PMCID: PMC10413431.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells. bioRxiv. 2023 Jul 19. Nguyen V, Kravitz J, Gao C, Hochman ML, Meng D, Chen D, Wang Y, Jegga AG, Nelson JS, Tan W. PMID: 37503303; PMCID: PMC10370126.
      View in: PubMed   Mentions:
    7. ERα/ERβ-directed CBS transcription mediates E2β-stimulated hUAEC H2S production. J Mol Endocrinol. 2023 02 01; 70(2). Bai J, Lechuga TJ, Makhoul J, Yan H, Major C, Hameed A, Chen DB. PMID: 36476832; PMCID: PMC9876575.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. W-Compound can be used as a Biomarker for Fetal Thyroid Function and a Potential Tool for Screening Congenital Hypothyroidism. Endocrinol Disord. 2022; 6(3). Wu SY, Zhao H, Xi BX, Chen DB, Fucito ME. PMID: 36843622; PMCID: PMC9957539.
      View in: PubMed   Mentions: 1  
    9. AT2R activation increases in vitro angiogenesis in pregnant human uterine artery endothelial cells. PLoS One. 2022; 4(17):e0267826. Jay S. Mishra, Dong-Bao Chen, Sathish Kumar . View Publication.
    10. Estrogen-Induced Uterine Vasodilation in Pregnancy and Preeclampsia. Matern Fetal Med. 2022 Jan; 4(1):52-60. Li Y, Han B, Salmeron AG, Bai J, Chen DB. PMID: 35072088; PMCID: PMC8772435.
      View in: PubMed   Mentions: 2  
    11. Maternal 3,3'-Diiodothyronine Sulfate Formation from Guinea Pig Placenta Perfused with 3,3',5-Triodothyronine. Endocrinol Disord. 2021 Sep; 5(7):01-6. Wu SY, Emerson CH, Tjioe E, Chen DB. PMID: 35098142; PMCID: PMC8797160.
      View in: PubMed   Mentions: 1  
    12. Enhanced Sp1/YY1 Expression Directs CBS Transcription to Mediate VEGF-Stimulated Pregnancy-Dependent H2S Production in Human Uterine Artery Endothelial Cells. Hypertension. 2021 12; 78(6):1902-1913. Bai J, Chen DB. PMID: 34657441; PMCID: PMC8585697.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. A Non-Invasive Determination of LOXL1 and Fibulin-5 Levels in the Vaginal Secretions of Women with and Without Pelvic Organ Prolapse. J Med Res Surg. 2021 Apr; 2(2). Garcia B, Arthur A, Patel B, Chang J, Chen D, Lane F. PMID: 34318305; PMCID: PMC8312730.
      View in: PubMed   Mentions: 2  
    14. Vascular smooth muscle cells during spiral artery remodeling in early human pregnancy†. Biol Reprod. 2021 02 11; 104(2):252-254. Chen DB, Magness RR. PMID: 33300560; PMCID: PMC7876661.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Corrigendum to: "Trophoblast H2S Maintains Early Pregnancy via Regulating Maternal-Fetal Interface Immune Hemostasis". J Clin Endocrinol Metab. 2021 01 23; 106(2):e1070. PMID: 33325505; PMCID: PMC7823231.
      View in: PubMed   Mentions:    Fields:    
    16. Trophoblast H2S Maintains Early Pregnancy via Regulating Maternal-Fetal Interface Immune Hemostasis. J Clin Endocrinol Metab. 2020 12 01; 105(12). Wang B, Xu T, Li Y, Wang W, Lyu C, Luo D, Yang Q, Ning N, Chen ZJ, Yan J, Chen DB, Li J. PMID: 32506120; PMCID: PMC7526739.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Uterine, vaginal and placental blood flows increase with dynamic changes in serum metabolic parameters and oxidative stress across gestation in buffaloes. Reprod Domest Anim. 2021 Jan; 56(1):142-152. Elmetwally MA, Elshopakey GE, Eldomany W, Eldesouky A, Samy A, Lenis YY, Chen DB. PMID: 33174231.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    18. Hydrogen Sulfide Relaxes Human Uterine Artery via Activating Smooth Muscle BKCa Channels. Antioxidants (Basel). 2020 Nov 13; 9(11). Li Y, Bai J, Yang YH, Hoshi N, Chen DB. PMID: 33202933; PMCID: PMC7697977.
      View in: PubMed   Mentions: 13  
    19. Enhanced Stromal Cell CBS-H2S Production Promotes Estrogen-Stimulated Human Endometrial Angiogenesis. Endocrinology. 2020 11 01; 161(11). Qi QR, Lechuga TJ, Patel B, Nguyen NA, Yang YH, Li Y, Sarnthiyakul S, Zhang QW, Bai J, Makhoul J, Chen DB. PMID: 32987401; PMCID: PMC7575054.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    20. Estrogen Receptors and Estrogen-Induced Uterine Vasodilation in Pregnancy. Int J Mol Sci. 2020 Jun 18; 21(12). Bai J, Qi QR, Li Y, Day R, Makhoul J, Magness RR, Chen DB. PMID: 32570961; PMCID: PMC7352873.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    21. Estrogen Receptor-β Mediates Estradiol-Induced Pregnancy-Specific Uterine Artery Endothelial Cell Angiotensin Type-2 Receptor Expression. Hypertension. 2019 10; 74(4):967-974. Mishra JS, Te Riele GM, Qi QR, Lechuga TJ, Gopalakrishnan K, Chen DB, Kumar S. PMID: 31378106; PMCID: PMC6739159.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    22. Ovine uterine artery hydrogen sulfide biosynthesis in vivo: effects of ovarian cycle and pregnancy†. Biol Reprod. 2019 06 01; 100(6):1630-1636. Lechuga TJ, Qi QR, Magness RR, Chen DB. PMID: 30772913; PMCID: PMC6561857.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    23. Structural analysis of estrogen receptors: interaction between estrogen receptors and cav-1 within the caveolae†. Biol Reprod. 2019 02 01; 100(2):495-504. Pastore MB, Landeros RV, Chen DB, Magness RR. PMID: 30137221; PMCID: PMC7302512.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    24. E2β stimulates ovine uterine artery endothelial cell H2S production in vitro by estrogen receptor-dependent upregulation of cystathionine β-synthase and cystathionine γ-lyase expression†. Biol Reprod. 2019 02 01; 100(2):514-522. Lechuga TJ, Qi QR, Kim T, Magness RR, Chen DB. PMID: 30277497; PMCID: PMC6378861.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. Analysis of Vascular Hydrogen Sulfide Biosynthesis. Methods Mol Biol. 2019; 2007:19-36. Lechuga TJ, Chen DB. PMID: 31148104; PMCID: PMC8916086.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    26. Revolutionize livestock breeding in the future: an animal embryo-stem cell breeding system in a dish. J Anim Sci Biotechnol. 2018; 9:90. Hou Z, An L, Han J, Yuan Y, Chen D, Tian J. PMID: 30568797; PMCID: PMC6298008.
      View in: PubMed   Mentions: 2  
    27. Estradiol-17β stimulates H2 S biosynthesis by ER-dependent CBS and CSE transcription in uterine artery smooth muscle cells in vitro. J Cell Physiol. 2019 06; 234(6):9264-9273. Lechuga TJ, Bilg AK, Patel BA, Nguyen NA, Qi QR, Chen DB. PMID: 30317617; PMCID: PMC6395496.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    28. Membrane trafficking and exocytosis are upregulated in port wine stain blood vessels. Histol Histopathol. 2019 May; 34(5):479-490. Yin R, Rice SJ, Wang J, Gao L, Tsai J, Anvari RT, Zhou F, Liu X, Wang G, Tang Y, Mihm MC, Belani CP, Chen DB, Nelson JS, Tan W. PMID: 30302745; PMCID: PMC6594380.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    29. A single-cell epigenetic model for paternal psychological stress-induced transgenerational reprogramming in offspring. Biol Reprod. 2018 06 01; 98(6):846-855. Lei J, Nie Q, Chen DB. PMID: 29506130; PMCID: PMC5991201.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    30. Correction: Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells. Oncotarget. 2018 04 03; 9(25):17978. Zhu XX, Yan YW, Chen D, Ai CZ, Lu X, Xu SS, Jiang S, Zhong GS, Chen DB, Jiang YZ. PMID: 29707162; PMCID: PMC5915170.
      View in: PubMed   Mentions: 1     Fields:    
    31. Human trophoblast-derived hydrogen sulfide stimulates placental artery endothelial cell angiogenesis. Biol Reprod. 2017 Sep 01; 97(3):478-489. Chen DB, Feng L, Hodges JK, Lechuga TJ, Zhang H. PMID: 29024947; PMCID: PMC6248441.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    32. Pregnancy Augments VEGF-Stimulated In Vitro Angiogenesis and Vasodilator (NO and H2S) Production in Human Uterine Artery Endothelial Cells. J Clin Endocrinol Metab. 2017 07 01; 102(7):2382-2393. Zhang HH, Chen JC, Sheibani L, Lechuga TJ, Chen DB. PMID: 28398541; PMCID: PMC5505189.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    33. Augmented H2S production via cystathionine-beta-synthase upregulation plays a role in pregnancy-associated uterine vasodilation. Biol Reprod. 2017 03 01; 96(3):664-672. Sheibani L, Lechuga TJ, Zhang H, Hameed A, Wing DA, Kumar S, Rosenfeld CR, Chen DB. PMID: 28339573; PMCID: PMC6366540.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    34. Effects of the histone deacetylase inhibitor 'Scriptaid' on the developmental competence of mouse embryos generated through round spermatid injection. Hum Reprod. 2017 01; 32(1):76-87. Kong P, Yin M, Chen D, Li S, Li Y, Xing F, Jiang M, Fang Z, Lyu Q, Chen X. PMID: 27864358.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    35. Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells. Oncotarget. 2016 Sep 27; 7(39):63561-63570. Zhu XX, Yan YW, Chen D, Ai CZ, Lu X, Xu SS, Jiang S, Zhong GS, Chen DB, Jiang YZ. PMID: 27566578; PMCID: PMC5325385.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    36. Quantitative Proteomics Analysis of VEGF-Responsive Endothelial Protein S-Nitrosylation Using Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and LC-MS/MS. Biol Reprod. 2016 05; 94(5):114. Zhang HH, Lechuga TJ, Chen Y, Yang Y, Huang L, Chen DB. PMID: 27075618; PMCID: PMC4939742.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    37. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3197-202. Tan K, An L, Miao K, Ren L, Hou Z, Tao L, Zhang Z, Wang X, Xia W, Liu J, Wang Z, Xi G, Gao S, Sui L, Zhu DS, Wang S, Wu Z, Bach I, Chen DB, Tian J. PMID: 26951653; PMCID: PMC4812732.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    38. Paternal Psychological Stress Reprograms Hepatic Gluconeogenesis in Offspring. Cell Metab. 2016 Apr 12; 23(4):735-43. Wu L, Lu Y, Jiao Y, Liu B, Li S, Li Y, Xing F, Chen D, Liu X, Zhao J, Xiong X, Gu Y, Lu J, Chen X, Li X. PMID: 26908462.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    39. Estrogen Replacement Therapy in Ovariectomized Nonpregnant Ewes Stimulates Uterine Artery Hydrogen Sulfide Biosynthesis by Selectively Up-Regulating Cystathionine β-Synthase Expression. Endocrinology. 2015 Jun; 156(6):2288-98. Lechuga TJ, Zhang HH, Sheibani L, Karim M, Jia J, Magness RR, Rosenfeld CR, Chen DB. PMID: 25825818; PMCID: PMC4430606.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    40. S-nitrosylation of Cofilin-1 Serves as a Novel Pathway for VEGF-Stimulated Endothelial Cell Migration. J Cell Physiol. 2015 Feb; 230(2):406-17. Zhang HH, Wang W, Feng L, Yang Y, Zheng J, Huang L, Chen DB. PMID: 25056928; PMCID: PMC8906234.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    41. S-nitrosylation of cofilin-1 mediates estradiol-17β-stimulated endothelial cytoskeleton remodeling. Mol Endocrinol. 2015 Mar; 29(3):434-44. Zhang HH, Lechuga TJ, Tith T, Wang W, Wing DA, Chen DB. PMID: 25635941; PMCID: PMC4347286.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    42. Endogenous NO upon estradiol-17β stimulation and NO donor differentially regulate mitochondrial S-nitrosylation in endothelial cells. Endocrinology. 2014 Aug; 155(8):3005-16. Satohisa S, Zhang HH, Feng L, Yang YY, Huang L, Chen DB. PMID: 24877627; PMCID: PMC4098011.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    43. Distinct roles of HIF1A in endothelial adaptations to physiological and ambient oxygen. Mol Cell Endocrinol. 2014 Jun 25; 391(1-2):60-7. Jiang YZ, Li Y, Wang K, Dai CF, Huang SA, Chen DB, Zheng J. PMID: 24796659; PMCID: PMC4079002.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    44. Regulation of placental angiogenesis. Microcirculation. 2014 Jan; 21(1):15-25. Chen DB, Zheng J. PMID: 23981199; PMCID: PMC5589442.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    45. Enhanced cellular responses and distinct gene profiles in human fetoplacental artery endothelial cells under chronic low oxygen. Biol Reprod. 2013 Dec; 89(6):133. Jiang YZ, Wang K, Li Y, Dai CF, Wang P, Kendziorski C, Chen DB, Zheng J. PMID: 24152727; PMCID: PMC4076354.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    46. Human placental microRNAs and preeclampsia. Biol Reprod. 2013 May; 88(5):130. Chen DB, Wang W. PMID: 23575145; PMCID: PMC4013914.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    47. Transcriptional and functional adaptations of human endothelial cells to physiological chronic low oxygen. Biol Reprod. 2013 May; 88(5):114. Jiang YZ, Wang K, Li Y, Dai CF, Wang P, Kendziorski C, Chen DB, Zheng J. PMID: 23536375; PMCID: PMC4013893.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    48. Nitric oxide and carbon monoxide production and metabolism in preeclampsia. Reprod Sci. 2013 May; 20(5):542-8. Ehsanipoor RM, Fortson W, Fitzmaurice LE, Liao WX, Wing DA, Chen DB, Chan K. PMID: 23012314; PMCID: PMC3713541.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    49. Compartmentalizing proximal FGFR1 signaling in ovine placental artery endothelial cell caveolae. Biol Reprod. 2012 Aug; 87(2):40. Feng L, Zhang HH, Wang W, Zheng J, Chen DB. PMID: 22674390; PMCID: PMC3431425.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    50. Caveolin-1 orchestrates fibroblast growth factor 2 signaling control of angiogenesis in placental artery endothelial cell caveolae. J Cell Physiol. 2012 Jun; 227(6):2480-91. Feng L, Liao WX, Luo Q, Zhang HH, Wang W, Zheng J, Chen DB. PMID: 21830216; PMCID: PMC3248968.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    51. Human placental expression of SLIT/ROBO signaling cues: effects of preeclampsia and hypoxia. Biol Reprod. 2012 Apr; 86(4):111. Liao WX, Laurent LC, Agent S, Hodges J, Chen DB. PMID: 22262697; PMCID: PMC3338657.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    52. Endothelial caveolar hub regulation of adenosine triphosphate-induced endothelial nitric oxide synthase subcellular partitioning and domain-specific phosphorylation. Hypertension. 2012 May; 59(5):1052-9. Ramadoss J, Liao WX, Morschauser TJ, Lopez GE, Patankar MS, Chen DB, Magness RR. PMID: 22454479; PMCID: PMC3337759.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    53. Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta. J Clin Endocrinol Metab. 2012 Jun; 97(6):E1051-9. Wang W, Feng L, Zhang H, Hachy S, Satohisa S, Laurent LC, Parast M, Zheng J, Chen DB. PMID: 22438230; PMCID: PMC3387422.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    54. Estrogen-responsive nitroso-proteome in uterine artery endothelial cells: role of endothelial nitric oxide synthase and estrogen receptor-β. J Cell Physiol. 2012 Jan; 227(1):146-59. Zhang HH, Feng L, Wang W, Magness RR, Chen DB. PMID: 21374595; PMCID: PMC3125455.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    55. Analysis of nitroso-proteomes in normotensive and severe preeclamptic human placentas. Biol Reprod. 2011 May; 84(5):966-75. Zhang HH, Wang YP, Chen DB. PMID: 21228217; PMCID: PMC3080422.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    56. Rac1-dependent intracellular superoxide formation mediates vascular endothelial growth factor-induced placental angiogenesis in vitro. Endocrinology. 2010 Nov; 151(11):5315-25. Li SM, Zeng LW, Feng L, Chen DB. PMID: 20844008; PMCID: PMC2954717.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    57. Perspectives of SLIT/ROBO signaling in placental angiogenesis. Histol Histopathol. 2010 09; 25(9):1181-90. Liao WX, Wing DA, Geng JG, Chen DB. PMID: 20607660; PMCID: PMC8900672.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    58. Regulation of caveolin-1 expression and phosphorylation by VEGF in ovine amnion cells. Reprod Sci. 2010 Dec; 17(12):1112-9. Cheung CY, Li S, Chen D, Brace RA. PMID: 20720263; PMCID: PMC3965204.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    59. Estradiol-17beta stimulates specific receptor and endogenous nitric oxide-dependent dynamic endothelial protein S-nitrosylation: analysis of endothelial nitrosyl-proteome. Endocrinology. 2010 Aug; 151(8):3874-87. Zhang HH, Feng L, Livnat I, Hoh JK, Shim JY, Liao WX, Chen DB. PMID: 20519370; PMCID: PMC2940521.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    60. Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factor. Endocrinology. 2010 Jul; 151(7):3432-44. Liao WX, Feng L, Zheng J, Chen DB. PMID: 20463056; PMCID: PMC2903938.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    61. Activation of AP-1 transcription factors differentiates FGF2 and vascular endothelial growth factor regulation of endothelial nitric-oxide synthase expression in placental artery endothelial cells. J Biol Chem. 2010 Jun 04; 285(23):17348-58. Mata-Greenwood E, Liao WX, Wang W, Zheng J, Chen DB. PMID: 20371606; PMCID: PMC2878498.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    62. High-throughput caveolar proteomic signature profile for maternal binge alcohol consumption. Alcohol. 2010 Nov-Dec; 44(7-8):691-7. Ramadoss J, Liao WX, Chen DB, Magness RR. PMID: 20053519; PMCID: PMC2889021.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    63. Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways. Placenta. 2009 Dec; 30(12):1045-51. Wang K, Jiang YZ, Chen DB, Zheng J. PMID: 19892399; PMCID: PMC2788063.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    64. Suppression of protein phosphatase 2 differentially modulates VEGF- and FGF2-induced signaling in ovine fetoplacental artery endothelial cells. Placenta. 2009 Oct; 30(10):907-13. Song Y, Wang K, Chen DB, Magness RR, Zheng J. PMID: 19692121; PMCID: PMC2748137.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    65. Compartmentalizing VEGF-induced ERK2/1 signaling in placental artery endothelial cell caveolae: a paradoxical role of caveolin-1 in placental angiogenesis in vitro. Mol Endocrinol. 2009 Sep; 23(9):1428-44. Liao WX, Feng L, Zhang H, Zheng J, Moore TR, Chen DB. PMID: 19477952; PMCID: PMC2737550.
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    66. Effects of disulfide bond reducing agents on sperm chromatin structural integrity and developmental competence of in vitro matured oocytes after intracytoplasmic sperm injection in pigs. Reproduction. 2009 Apr; 137(4):633-43. Cheng WM, An L, Wu ZH, Zhu YB, Liu JH, Gao HM, Li XH, Zheng SJ, Chen DB, Tian JH. PMID: 19155332.
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    67. Differential activation of multiple signalling pathways dictates eNOS upregulation by FGF2 but not VEGF in placental artery endothelial cells. Placenta. 2008 Aug; 29(8):708-17. Mata-Greenwood E, Liao WX, Zheng J, Chen DB. PMID: 18571718; PMCID: PMC2596925.
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    68. Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial cells. Biol Reprod. 2008 Oct; 79(4):704-10. Wang K, Song Y, Chen DB, Zheng J. PMID: 18509162; PMCID: PMC2574765.
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    69. Gender-specific protection of estrogen against gastric acid-induced duodenal injury: stimulation of duodenal mucosal bicarbonate secretion. Endocrinology. 2008 Sep; 149(9):4554-66. Smith A, Contreras C, Ko KH, Chow J, Dong X, Tuo B, Zhang HH, Chen DB, Dong H. PMID: 18499763; PMCID: PMC2553385.
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    70. Racial differences in nitric oxide-dependent vasorelaxation. Reprod Sci. 2008 Jan; 15(1):9-25. Mata-Greenwood E, Chen DB. PMID: 18212350; PMCID: PMC2459254.
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    71. Prostaglandin F2alpha stimulates the expression and secretion of transforming growth factor B1 via induction of the early growth response 1 gene (EGR1) in the bovine corpus luteum. Mol Endocrinol. 2008 Feb; 22(2):403-14. Hou X, Arvisais EW, Jiang C, Chen DB, Roy SK, Pate JL, Hansen TR, Rueda BR, Davis JS. PMID: 17916653; PMCID: PMC2234593.
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    72. Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation. Biol Reprod. 2008 Jan; 78(1):143-50. Zheng J, Wen Y, Song Y, Wang K, Chen DB, Magness RR. PMID: 17901071; PMCID: PMC2441762.
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    73. Transcriptional regulation of endothelial nitric oxide synthase expression in uterine artery endothelial cells by c-Jun/AP-1. Mol Cell Endocrinol. 2007 Dec 15; 279(1-2):39-51. Qian XX, Mata-Greenwood E, Liao WX, Zhang H, Zheng J, Chen DB. PMID: 17933457; PMCID: PMC2131711.
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    74. Global protein expression profiling underlines reciprocal regulation of caveolin 1 and endothelial nitric oxide synthase expression in ovariectomized sheep uterine artery by estrogen/progesterone replacement therapy. Biol Reprod. 2006 May; 74(5):832-8. Chen DB, Jia S, King AG, Barker A, Li SM, Mata-Greenwood E, Zheng J, Magness RR. PMID: 16436525.
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    75. Exogenous nitric oxide stimulates cell proliferation via activation of a mitogen-activated protein kinase pathway in ovine fetoplacental artery endothelial cells. Biol Reprod. 2006 Feb; 74(2):375-82. Zheng J, Wen Y, Austin JL, Chen DB. PMID: 16251502.
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    76. Tyrosine phosphorylation of caveolin 1 by oxidative stress is reversible and dependent on the c-src tyrosine kinase but not mitogen-activated protein kinase pathways in placental artery endothelial cells. Biol Reprod. 2005 Oct; 73(4):761-72. Chen DB, Li SM, Qian XX, Moon C, Zheng J. PMID: 15958730.
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    77. Angiotensin II regulation of ovine fetoplacental artery endothelial functions: interactions with nitric oxide. J Physiol. 2005 May 15; 565(Pt 1):59-69. Zheng J, Bird IM, Chen DB, Magness RR. PMID: 15790666; PMCID: PMC1464493.
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    78. Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ERalpha and ERbeta levels. J Physiol. 2005 May 15; 565(Pt 1):85-99. Byers MJ, Zangl A, Phernetton TM, Lopez G, Chen DB, Magness RR. PMID: 15774511; PMCID: PMC1464491.
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    79. Uterine blood flow responses to ICI 182 780 in ovariectomized oestradiol-17beta-treated, intact follicular and pregnant sheep. J Physiol. 2005 May 15; 565(Pt 1):71-83. Magness RR, Phernetton TM, Gibson TC, Chen DB. PMID: 15774510; PMCID: PMC1464500.
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    80. Angiotensin II elevates nitric oxide synthase 3 expression and nitric oxide production via a mitogen-activated protein kinase cascade in ovine fetoplacental artery endothelial cells. Biol Reprod. 2005 Jun; 72(6):1421-8. Zheng J, Wen Y, Chen DB, Bird IM, Magness RR. PMID: 15728793.
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    81. Expression of estrogen receptors-alpha and -beta in the pregnant ovine uterine artery endothelial cells in vivo and in vitro. Biol Reprod. 2005 Mar; 72(3):530-7. Liao WX, Magness RR, Chen DB. PMID: 15564597.
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    82. Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells. Endocrinology. 2004 Jan; 145(1):113-25. Chen DB, Bird IM, Zheng J, Magness RR. PMID: 14512434.
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    83. Epidermal growth factor induces c-fos and c-jun mRNA via Raf-1/MEK1/ERK-dependent and -independent pathways in bovine luteal cells. Mol Cell Endocrinol. 2003 Feb 28; 200(1-2):141-54. Chen DB, Davis JS. PMID: 12644307.
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    84. Co-expression of vascular endothelial growth factor and neuropilin-1 in ovine feto-placental artery endothelial cells. Mol Cell Endocrinol. 2002 Oct 31; 196(1-2):95-106. Tsoi SC, Wen Y, Chung JY, Chen D, Magness RR, Zheng J. PMID: 12385828.
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    85. Ovine caveolin-1: cDNA cloning, E. coli expression, and association with endothelial nitric oxide synthase. Mol Cell Endocrinol. 2001 Apr 25; 175(1-2):41-56. Chen D, Zangl AL, Zhao Q, Markley JL, Zheng J, Bird IM, Magness RR. PMID: 11325515.
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    86. Induction of c-fos and c-jun messenger ribonucleic acid expression by prostaglandin F2alpha is mediated by a protein kinase C-dependent extracellular signal-regulated kinase mitogen-activated protein kinase pathway in bovine luteal cells. Endocrinology. 2001 Feb; 142(2):887-95. Chen D, Fong HW, Davis JS. PMID: 11159862.
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    87. Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells. Endocrinology. 1998 Sep; 139(9):3876-85. Chen DB, Westfall SD, Fong HW, Roberson MS, Davis JS. PMID: 9724043.
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    88. Leukemia inhibitory factor, LIF receptor, and gp130 in the mouse uterus during early pregnancy. Mol Reprod Dev. 1995 Dec; 42(4):407-14. Yang ZM, Le SP, Chen DB, Cota J, Siero V, Yasukawa K, Harper MJ. PMID: 8607969.
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    89. Differential metabolism of exogenous platelet-activating factor by glandular epithelial and stromal cells of rabbit endometrium. J Reprod Fertil. 1995 Nov; 105(2):315-24. Kudolo GB, Yang YQ, Chen DB, Jones MA, Harper MJ. PMID: 8568777.
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    90. Stimulation of prostaglandin (PG) F2 alpha and PGE2 release by tumour necrosis factor-alpha and interleukin-1 alpha in cultured human luteal phase endometrial cells. Hum Reprod. 1995 Oct; 10(10):2773-80. Chen DB, Yang ZM, Hilsenrath R, Le SP, Harper MJ. PMID: 8567812.
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    91. Interleukin-1 alpha in the rabbit uterus during early pregnancy. Early Pregnancy. 1995 Sep; 1(3):201-5. Yang ZM, Chen DB, Le SP, Harper MJ. PMID: 9363252.
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    92. Leukaemia inhibitory factor in human endometrium during the menstrual cycle: cellular origin and action on production of glandular epithelial cell prostaglandin in vitro. Hum Reprod. 1995 Apr; 10(4):911-8. Chen DB, Hilsenrath R, Yang ZM, Le SP, Kim SR, Chuong CJ, Poindexter AN, Harper MJ. PMID: 7650142.
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    93. Expression patterns of leukaemia inhibitory factor receptor (LIFR) and the gp130 receptor component in rabbit uterus during early pregnancy. J Reprod Fertil. 1995 Mar; 103(2):249-55. Yang ZM, Le SP, Chen DB, Yasukawa K, Harper MJ. PMID: 7616497.
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    94. Temporal and spatial expression of leukemia inhibitory factor in rabbit uterus during early pregnancy. Mol Reprod Dev. 1994 Jun; 38(2):148-52. Yang ZM, Le SP, Chen DB, Harper MJ. PMID: 8080643.
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