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Middlebrooks, John C

Title(s)Professor, Otolaryngology
Phone(949) 824-0119
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    Collapse Research 
    Collapse Research Activities and Funding
    Enhanced auditory prosthesis using a penetrating auditory-nerve electrode
    NIH/NIDCD R01DC017182Apr 11, 2019 - Mar 31, 2024
    Role: Principal Investigator
    CORTICAL AND BEHAVIORAL RESPONSES TO COCHLEAR IMPLANTS
    NIH/NIDCD R01DC004312Jan 1, 2000 - Nov 30, 2010
    Role: Principal Investigator
    CORTICAL REPRESENTATION OF AUDITORY SPACE
    NIH/NIDCD R29DC000420Jul 1, 1987 - Jun 30, 1995
    Role: Principal Investigator
    CORTICAL REPRESENTATION OF AUDITORY SPACE
    NIH/NINDS R29NS025022Jul 1, 1987 - Jun 30, 1992
    Role: Principal Investigator
    Cortical Representation of Auditory Space
    NIH/NIDCD R01DC000420Jun 1, 1987 - May 31, 2019
    Role: Principal Investigator
    PERCEPTION AND PROCESSING OF COMPLEX BIOLOGICAL SIGNALS
    NIH/NIDCD P01DC000078Sep 1, 1977 - Nov 30, 2003
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xu Y, Luo C, Zeng FG, Middlebrooks JC, Lin HW, You Z. Design, Fabrication and Evaluation of A Parylene Thin Film Electrode Array for Cochlear Implants. IEEE Trans Biomed Eng. 2018 Jul 10. PMID: 30004866.
      View in: PubMed
    2. Middlebrooks JC. Chronic Deafness Degrades Temporal Acuity in the Electrically Stimulated Auditory Pathway. J Assoc Res Otolaryngol. 2018 Oct; 19(5):541-557. PMID: 29968099.
      View in: PubMed
    3. Presacco A, Middlebrooks JC. Tone-Evoked Acoustic Change Complex (ACC) Recorded in a Sedated Animal Model. J Assoc Res Otolaryngol. 2018 Aug; 19(4):451-466. PMID: 29749573.
      View in: PubMed
    4. Xu Y, Luo C, Zeng FG, Middlebrooks JC, Lin HW, You Z. Study of the Carrier-Aided Thin Film Electrode Array Design for Cochlear Insertion. Micromachines (Basel). 2018 Apr 27; 9(5). PMID: 30424139.
      View in: PubMed
    5. Middlebrooks JC. Masking release by combined spatial and masker-fluctuation effects in the open sound field. J Acoust Soc Am. 2017 Dec; 142(6):3362. PMID: 29289075.
      View in: PubMed
    6. Haidar YM, Sahyouni R, Moshtaghi O, Wang BY, Djalilian HR, Middlebrooks JC, Verma SP, Lin HW. Selective recurrent laryngeal nerve stimulation using a penetrating electrode array in the feline model. Laryngoscope. 2018 Jul; 128(7):1606-1614. PMID: 29086427.
      View in: PubMed
    7. Sahyouni R, Haidar YM, Moshtaghi O, Wang BY, Djalilian HR, Middlebrooks JC, Lin HW. Selective Stimulation of Facial Muscles Following Chronic Intraneural Electrode Array Implantation and Facial Nerve Injury in the Feline Model. Otol Neurotol. 2017 10; 38(9):e369-e377. PMID: 28834941.
      View in: PubMed
    8. Sahyouni R, Bhatt J, Djalilian HR, Tang WC, Middlebrooks JC, Lin HW. Selective stimulation of facial muscles with a penetrating electrode array in the feline model. Laryngoscope. 2017 02; 127(2):460-465. PMID: 27312936.
      View in: PubMed
    9. Javier LK, McGuire EA, Middlebrooks JC. Spatial Stream Segregation by Cats. J Assoc Res Otolaryngol. 2016 06; 17(3):195-207. PMID: 26993807; PMCID: PMC4854824.
      View in: PubMed, PubMed Central
    10. Yao JD, Bremen P, Middlebrooks JC. Emergence of Spatial Stream Segregation in the Ascending Auditory Pathway. J Neurosci. 2015 Dec 09; 35(49):16199-212. PMID: 26658870; PMCID: PMC4682785.
      View in: PubMed, PubMed Central
    11. Pham CQ, Bremen P, Shen W, Yang SM, Middlebrooks JC, Zeng FG, Mc Laughlin M. Central Auditory Processing of Temporal and Spectral-Variance Cues in Cochlear Implant Listeners. PLoS One. 2015; 10(7):e0132423. PMID: 26176553; PMCID: PMC4503639.
      View in: PubMed, PubMed Central
    12. Yao JD, Bremen P, Middlebrooks JC. Transformation of spatial sensitivity along the ascending auditory pathway. J Neurophysiol. 2015 May 01; 113(9):3098-111. PMID: 25744891; PMCID: PMC4455560.
      View in: PubMed, PubMed Central
    13. Middlebrooks JC. Sound localization. Handb Clin Neurol. 2015; 129:99-116. PMID: 25726265.
      View in: PubMed
    14. Middlebrooks JC, Nick HS, Subramony SH, Advincula J, Rosales RL, Lee LV, Ashizawa T, Waters MF. Mutation in the kv3.3 voltage-gated potassium channel causing spinocerebellar ataxia 13 disrupts sound-localization mechanisms. PLoS One. 2013; 8(10):e76749. PMID: 24116147; PMCID: PMC3792041.
      View in: PubMed, PubMed Central
    15. Yao JD, Bremen P, Middlebrooks JC. Rat primary auditory cortex is tuned exclusively to the contralateral hemifield. J Neurophysiol. 2013 Nov; 110(9):2140-51. PMID: 23945782; PMCID: PMC3841933.
      View in: PubMed, PubMed Central
    16. Middlebrooks JC, Bremen P. Spatial stream segregation by auditory cortical neurons. J Neurosci. 2013 Jul 03; 33(27):10986-1001. PMID: 23825404; PMCID: PMC3718378.
      View in: PubMed, PubMed Central
    17. Bremen P, Middlebrooks JC. Weighting of spatial and spectro-temporal cues for auditory scene analysis by human listeners. PLoS One. 2013; 8(3):e59815. PMID: 23527271; PMCID: PMC3602423.
      View in: PubMed, PubMed Central
    18. Kiumehr S, Mahboubi H, Middlebrooks JC, Djalilian HR. Transcanal approach for implantation of a cochlear nerve electrode array. Laryngoscope. 2013 May; 123(5):1261-5. PMID: 23460260.
      View in: PubMed
    19. Middlebrooks JC. High-acuity spatial stream segregation. Adv Exp Med Biol. 2013; 787:491-9. PMID: 23716256.
      View in: PubMed
    20. Middlebrooks JC, Onsan ZA. Stream segregation with high spatial acuity. J Acoust Soc Am. 2012 Dec; 132(6):3896-911. PMID: 23231120; PMCID: PMC3528685.
      View in: PubMed, PubMed Central
    21. Lee CC, Middlebrooks JC. Specialization for sound localization in fields A1, DZ, and PAF of cat auditory cortex. J Assoc Res Otolaryngol. 2013 Feb; 14(1):61-82. PMID: 23180228; PMCID: PMC3540280.
      View in: PubMed, PubMed Central
    22. Merlo MW, Snyder RL, Middlebrooks JC, Bachman M. Microelectrode arrays fabricated using a novel hybrid microfabrication method. Biomed Microdevices. 2012 Feb; 14(1):193-205. PMID: 21979567.
      View in: PubMed
    23. Pfingst BE, Colesa DJ, Hembrador S, Kang SY, Middlebrooks JC, Raphael Y, Su GL. Detection of pulse trains in the electrically stimulated cochlea: effects of cochlear health. J Acoust Soc Am. 2011 Dec; 130(6):3954-68. PMID: 22225050; PMCID: PMC3253597.
      View in: PubMed, PubMed Central
    24. Kirby AE, Middlebrooks JC. Unanesthetized auditory cortex exhibits multiple codes for gaps in cochlear implant pulse trains. J Assoc Res Otolaryngol. 2012 Feb; 13(1):67-80. PMID: 21969022; PMCID: PMC3254721.
      View in: PubMed, PubMed Central
    25. Lee CC, Middlebrooks JC. Auditory cortex spatial sensitivity sharpens during task performance. Nat Neurosci. 2011 Jan; 14(1):108-14. PMID: 21151120; PMCID: PMC3076022.
      View in: PubMed, PubMed Central
    26. Bierer JA, Bierer SM, Middlebrooks JC. Partial tripolar cochlear implant stimulation: Spread of excitation and forward masking in the inferior colliculus. Hear Res. 2010 Dec 01; 270(1-2):134-42. PMID: 20727397; PMCID: PMC2997905.
      View in: PubMed, PubMed Central
    27. Middlebrooks JC, Snyder RL. Selective electrical stimulation of the auditory nerve activates a pathway specialized for high temporal acuity. J Neurosci. 2010 Feb 03; 30(5):1937-46. PMID: 20130202; PMCID: PMC2828779.
      View in: PubMed, PubMed Central
    28. Kirby AE, Middlebrooks JC. Auditory temporal acuity probed with cochlear implant stimulation and cortical recording. J Neurophysiol. 2010 Jan; 103(1):531-42. PMID: 19923242; PMCID: PMC2807213.
      View in: PubMed, PubMed Central
    29. Middlebrooks JC. Cochlear-implant high pulse rate and narrow electrode configuration impair transmission of temporal information to the auditory cortex. J Neurophysiol. 2008 Jul; 100(1):92-107. PMID: 18450583; PMCID: PMC2493502.
      View in: PubMed, PubMed Central
    30. Middlebrooks JC, Snyder RL. Intraneural stimulation for auditory prosthesis: modiolar trunk and intracranial stimulation sites. Hear Res. 2008 Aug; 242(1-2):52-63. PMID: 18485635.
      View in: PubMed
    31. Middlebrooks JC. Auditory cortex phase locking to amplitude-modulated cochlear implant pulse trains. J Neurophysiol. 2008 Jul; 100(1):76-91. PMID: 18367697; PMCID: PMC2493473.
      View in: PubMed, PubMed Central
    32. Harrington IA, Stecker GC, Macpherson EA, Middlebrooks JC. Spatial sensitivity of neurons in the anterior, posterior, and primary fields of cat auditory cortex. Hear Res. 2008 Jun; 240(1-2):22-41. PMID: 18359176; PMCID: PMC2515616.
      View in: PubMed, PubMed Central
    33. Malhotra S, Stecker GC, Middlebrooks JC, Lomber SG. Sound localization deficits during reversible deactivation of primary auditory cortex and/or the dorsal zone. J Neurophysiol. 2008 Apr; 99(4):1628-42. PMID: 18199813.
      View in: PubMed
    34. Snyder RL, Middlebrooks JC, Bonham BH. Cochlear implant electrode configuration effects on activation threshold and tonotopic selectivity. Hear Res. 2008 Jan; 235(1-2):23-38. PMID: 18037252.
      View in: PubMed
    35. Middlebrooks JC, Snyder RL. Auditory prosthesis with a penetrating nerve array. J Assoc Res Otolaryngol. 2007 Jun; 8(2):258-79. PMID: 17265124; PMCID: PMC2538356.
      View in: PubMed, PubMed Central
    36. Middlebrooks JC, Bierer JA, Snyder RL. Cochlear implants: the view from the brain. Curr Opin Neurobiol. 2005 Aug; 15(4):488-93. PMID: 16009544.
      View in: PubMed
    37. Middlebrooks JC. Auditory cortex cheers the overture and listens through the finale. Nat Neurosci. 2005 Jul; 8(7):851-2. PMID: 16136671.
      View in: PubMed
    38. Stecker GC, Harrington IA, Macpherson EA, Middlebrooks JC. Spatial sensitivity in the dorsal zone (area DZ) of cat auditory cortex. J Neurophysiol. 2005 Aug; 94(2):1267-80. PMID: 15857970.
      View in: PubMed
    39. Mickey BJ, Middlebrooks JC. Sensitivity of auditory cortical neurons to the locations of leading and lagging sounds. J Neurophysiol. 2005 Aug; 94(2):979-89. PMID: 15817648.
      View in: PubMed
    40. Stecker GC, Harrington IA, Middlebrooks JC. Location coding by opponent neural populations in the auditory cortex. PLoS Biol. 2005 Mar; 3(3):e78. PMID: 15736980; PMCID: PMC1044834.
      View in: PubMed, PubMed Central
    41. Sabin AT, Macpherson EA, Middlebrooks JC. Human sound localization at near-threshold levels. Hear Res. 2005 Jan; 199(1-2):124-34. PMID: 15574307.
      View in: PubMed
    42. Snyder RL, Bierer JA, Middlebrooks JC. Topographic spread of inferior colliculus activation in response to acoustic and intracochlear electric stimulation. J Assoc Res Otolaryngol. 2004 Sep; 5(3):305-22. PMID: 15492888; PMCID: PMC2504547.
      View in: PubMed, PubMed Central
    43. Middlebrooks JC. Effects of cochlear-implant pulse rate and inter-channel timing on channel interactions and thresholds. J Acoust Soc Am. 2004 Jul; 116(1):452-68. PMID: 15296005.
      View in: PubMed
    44. Stecker GC, Middlebrooks JC. Distributed coding of sound locations in the auditory cortex. Biol Cybern. 2003 Nov; 89(5):341-9. PMID: 14669014.
      View in: PubMed
    45. Middlebrooks JC. The acquisitive auditory cortex. Nat Neurosci. 2003 Nov; 6(11):1122-3. PMID: 14583750.
      View in: PubMed
    46. Bierer JA, Middlebrooks JC. Cortical responses to cochlear implant stimulation: channel interactions. J Assoc Res Otolaryngol. 2004 Mar; 5(1):32-48. PMID: 14564662; PMCID: PMC2538368.
      View in: PubMed, PubMed Central
    47. Mickey BJ, Middlebrooks JC. Representation of auditory space by cortical neurons in awake cats. J Neurosci. 2003 Sep 24; 23(25):8649-63. PMID: 14507964.
      View in: PubMed
    48. Macpherson EA, Middlebrooks JC. Vertical-plane sound localization probed with ripple-spectrum noise. J Acoust Soc Am. 2003 Jul; 114(1):430-45. PMID: 12880054.
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    49. Middlebrooks JC. Hearing phantoms. Focus on "Spectral cues explain illusory elevation effects with stereo sounds in cats". J Neurophysiol. 2003 Jul; 90(1):1. PMID: 12843302.
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    50. Stecker GC, Mickey BJ, Macpherson EA, Middlebrooks JC. Spatial sensitivity in field PAF of cat auditory cortex. J Neurophysiol. 2003 Jun; 89(6):2889-903. PMID: 12611946.
      View in: PubMed
    51. Middlebrooks JC. Auditory space processing: here, there or everywhere? Nat Neurosci. 2002 Sep; 5(9):824-6. PMID: 12196806.
      View in: PubMed
    52. Macpherson EA, Middlebrooks JC. Listener weighting of cues for lateral angle: the duplex theory of sound localization revisited. J Acoust Soc Am. 2002 May; 111(5 Pt 1):2219-36. PMID: 12051442.
      View in: PubMed
    53. Furukawa S, Middlebrooks JC. Cortical representation of auditory space: information-bearing features of spike patterns. J Neurophysiol. 2002 Apr; 87(4):1749-62. PMID: 11929896.
      View in: PubMed
    54. Middlebrooks JC, Xu L, Furukawa S, Macpherson EA. Cortical neurons that localize sounds. Neuroscientist. 2002 Feb; 8(1):73-83. PMID: 11843102.
      View in: PubMed
    55. Bierer JA, Middlebrooks JC. Auditory cortical images of cochlear-implant stimuli: dependence on electrode configuration. J Neurophysiol. 2002 Jan; 87(1):478-92. PMID: 11784764.
      View in: PubMed
    56. Middlebrooks JC, Bierer JA. Auditory cortical images of cochlear-implant stimuli: coding of stimulus channel and current level. J Neurophysiol. 2002 Jan; 87(1):493-507. PMID: 11784765.
      View in: PubMed
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