Haik Mkhikian

Title(s)Assistant Professor, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-1698
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    Collapse Biography 
    Collapse Education and Training
    UC Irvine, Irvine, CAFellowship01/2022Research Fellowship
    UC Irvine, Irvine, CAResidency06/2019Clinical Pathology
    UC Irvine, Irvine, CAMD06/2016Medicine
    UC Irvine, Irvine, CAPhD06/2014Glycoimmunology
    UC Irvine, Irvine, CABA06/2006Philosophy
    UC Irvine, Irvine, CABS06/2006Biochemistry and Molecular Biology
    Collapse Awards and Honors
    National Institutes of Health - NHLBI2011  - 2016Ruth L. Kirschstein National Research Service Award (NRSA) Fellowship (F30)
    UC Irvine - Microbiology and Molecular Genetics2013Harris S. Moyed Outstanding Graduate Student Award
    UC Irvine - School of Biological Sciences2005Laurence J. Mehlman Prize
    National Institutes of Health2005NIH UGSP Scholarship

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Differential regulation of T cell plasma membrane proteins by N-glycan branching and clathrin-mediated endocytosis
    NIH DP2AI164301Jun 15, 2022 - May 31, 2027
    Role: Principal Investigator
    Description: The N-glycan branching pathway controls immunity and inflammation by controlling turnover rates of proteins on the surface of T cells. However, which proteins are regulated in this manner, and how this pathway promotes expression of some proteins while inhibiting expression of others is unknown. We propose using a quantitative proteomic approach to analyze all surface proteins simultaneously and to examine the hypothesis that these extracellular glycans cooperate with intracellular endocytosis machinery to differentially regulate cell- surface protein turnover.
    N-glycosylation as a downstream effector of Interleukin-7
    NIH F30HL108451Apr 22, 2011 - Apr 21, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. T cell senescence by N-glycan branching. Aging (Albany NY). 2022 08 13; 14(15):5964-5965. Mkhikian H, Demetriou M. PMID: 35963641; PMCID: PMC9417233.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Age-associated impairment of T cell immunity is linked to sex-dimorphic elevation of N-glycan branching. Nat Aging. 2022 03; 2(3):231-242. Mkhikian H, Hayama KL, Khachikyan K, Li C, Zhou RW, Pawling J, Klaus S, Tran PQN, Ly KM, Gong AD, Saryan H, Hai JL, Grigoryan D, Lee PL, Newton BL, Raffatellu M, Dennis JW, Demetriou M. PMID: 35528547; PMCID: PMC9075523.
      View in: PubMed   Mentions: 7  Translation:HumansAnimalsCells
    3. A Striking Contrast. Clin Chem. 2018 08; 64(8):1265-1266. Mkhikian H, Crews BO. PMID: 30054304.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Long-term plasma exchange as maintenance therapy for cerebellar-type Hashimoto's encephalopathy, a case report. Transfus Apher Sci. 2018 Jun; 57(3):418-420. Tran MH, Mkhikian H, Sy M, Perez-Alvarez I, Demetriou M. PMID: 29891220.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation. Elife. 2017 01 06; 6. Araujo L, Khim P, Mkhikian H, Mortales CL, Demetriou M. PMID: 28059703; PMCID: PMC5257256.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    6. Exacerbation of myasthenia symptoms following intravenous iron administration. Transfus Med. 2016 Oct; 26(5):381-382. Mkhikian H, Tran MH. PMID: 27527607.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis. Elife. 2016 06 08; 5. Mkhikian H, Mortales CL, Zhou RW, Khachikyan K, Wu G, Haslam SM, Kavarian P, Dell A, Demetriou M. PMID: 27269286; PMCID: PMC4940165.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    8. N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca²⁺ signaling. Nat Immunol. 2014 Nov; 15(11):1038-45. Zhou RW, Mkhikian H, Grigorian A, Hong A, Chen D, Arakelyan A, Demetriou M. PMID: 25263124.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    9. Family studies of type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms. Genes Immun. 2014 Apr; 15(4):218-23. Yu Z, Li CF, Mkhikian H, Zhou RW, Newton BL, Demetriou M. PMID: 24572742; PMCID: PMC4047175.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    10. Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants. J Neuroimmunol. 2013 Mar 15; 256(1-2):71-6. Li CF, Zhou RW, Mkhikian H, Newton BL, Yu Z, Demetriou M. PMID: 23351704; PMCID: PMC4528623.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    11. Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation. Semin Immunopathol. 2012 May; 34(3):415-24. Grigorian A, Mkhikian H, Li CF, Newton BL, Zhou RW, Demetriou M. PMID: 22488447; PMCID: PMC3960996.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    12. Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation. Ann N Y Acad Sci. 2012 Apr; 1253:49-57. Grigorian A, Mkhikian H, Demetriou M. PMID: 22288682; PMCID: PMC4520414.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    13. Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun. 2011; 2:334. Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M. PMID: 21629267; PMCID: PMC3133923.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    14. Targeting neural precursors in the adult brain rescues injured dopamine neurons. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13570-5. Androutsellis-Theotokis A, Rueger MA, Park DM, Mkhikian H, Korb E, Poser SW, Walbridge S, Munasinghe J, Koretsky AP, Lonser RR, McKay RD. PMID: 19628689; PMCID: PMC2714762.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    15. Signaling pathways controlling neural stem cells slow progressive brain disease. Cold Spring Harb Symp Quant Biol. 2008; 73:403-10. Androutsellis-Theotokis A, Rueger MA, Mkhikian H, Korb E, McKay RD. PMID: 19022746.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
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