Michael E Selsted

Title(s)Professor Emeritus, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Collapse Research 
    Collapse Research Activities and Funding
    Host defense-stimulating macrocyclic peptides for treatment of MDR bacterial infections
    NIH R01AI125141May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Regulation of Mucosal Immunity by Pro- and Anti-inflammatory Salivary Defensins
    NIH R01DE021341Aug 12, 2010 - May 31, 2015
    Role: Principal Investigator
    Physiologic Peptide Cyclization in Myeloid Cells
    NIH R01AI058129Jun 1, 2004 - May 31, 2009
    Role: Principal Investigator
    Molecular Ontogeny of Oral Mucosal Resistance to SIV
    NIH R01DE015517Dec 15, 2003 - Nov 30, 2009
    Role: Principal Investigator
    DRUG DISCOVERY FOR TREATMENT OF CRYPTOCOCCAL DISEASE
    NIH U01AI031696Aug 1, 1991 - Jul 31, 1995
    Role: Principal Investigator
    MOLECULAR ASPECTS OF LEUKOCYTE ANTIMICROBIAL PEPTIDES
    NIH R37AI022931Jul 1, 1989 - Mar 31, 2012
    Role: Principal Investigator
    Molecular Aspects of Leukocyte Antimicrobial Peptides
    NIH R01AI022931Jul 1, 1986 - May 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A host-directed macrocyclic peptide therapeutic for MDR gram negative bacterial infections. Sci Rep. 2021 12 06; 11(1):23447. Schaal JB, Eriguchi Y, Tran DQ, Tran PA, Hawes C, Cabebe AE, Pike K, Trinh K, Ouellette AJ, Selsted ME. PMID: 34873199; PMCID: PMC8648872.
      View in: PubMed   Mentions:
    2. Host Defense Peptides as Templates for Antifungal Drug Development. J Fungi (Basel). 2020 Oct 23; 6(4). Basso V, Tran DQ, Ouellette AJ, Selsted ME. PMID: 33113935; PMCID: PMC7711597.
      View in: PubMed   Mentions: 3  
    3. Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms. Sci Rep. 2019 11 15; 9(1):16905. Basso V, Tran DQ, Schaal JB, Tran P, Eriguchi Y, Ngole D, Cabebe AE, Park AY, Beringer PM, Ouellette AJ, Selsted ME. PMID: 31729441; PMCID: PMC6858451.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. Essential role of IFN-γ in T cell-associated intestinal inflammation. JCI Insight. 2018 09 20; 3(18). Eriguchi Y, Nakamura K, Yokoi Y, Sugimoto R, Takahashi S, Hashimoto D, Teshima T, Ayabe T, Selsted ME, Ouellette AJ. PMID: 30232288; PMCID: PMC6237234.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    5. Fungicidal Potency and Mechanisms of θ-Defensins against Multidrug-Resistant Candida Species. Antimicrob Agents Chemother. 2018 06; 62(6). Basso V, Garcia A, Tran DQ, Schaal JB, Tran P, Ngole D, Aqeel Y, Tongaonkar P, Ouellette AJ, Selsted ME. PMID: 29610196; PMCID: PMC5971616.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    6. Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide. PLoS One. 2017; 12(11):e0187868. Schaal JB, Tran DQ, Subramanian A, Patel R, Laragione T, Roberts KD, Trinh K, Tongaonkar P, Tran PA, Minond D, Fields GB, Beringer P, Ouellette AJ, Gulko PS, Selsted ME. PMID: 29145473; PMCID: PMC5690597.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    7. Rhesus θ-defensin-1 (RTD-1) exhibits in vitro and in vivo activity against cystic fibrosis strains of Pseudomonas aeruginosa. J Antimicrob Chemother. 2016 Jan; 71(1):181-8. Beringer PM, Bensman TJ, Ho H, Agnello M, Denovel N, Nguyen A, Wong-Beringer A, She R, Tran DQ, Moskowitz SM, Selsted ME. PMID: 26433781; PMCID: PMC5007590.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    8. Rhesus macaque θ-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-κB and MAPK pathways. J Leukoc Biol. 2015 Dec; 98(6):1061-70. Tongaonkar P, Trinh KK, Schaal JB, Tran D, Gulko PS, Ouellette AJ, Selsted ME. PMID: 26269197; PMCID: PMC4661038.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    9. Differential Susceptibility of Bacteria to Mouse Paneth Cell α-Defensins under Anaerobic Conditions. Antibiotics (Basel). 2014; 3(4):493-508. Mastroianni JR, Lu W, Selsted ME, Ouellette AJ. PMID: 25383215; PMCID: PMC4220453.
      View in: PubMed   Mentions:
    10. Microbicidal effects of α- and θ-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Innate Immun. 2015 Jan; 21(1):17-29. Tai KP, Kamdar K, Yamaki J, Le VV, Tran D, Tran P, Selsted ME, Ouellette AJ, Wong-Beringer A. PMID: 24345876; PMCID: PMC4062604.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    11. Immunology. HD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. Ouellette AJ, Selsted ME. PMID: 22837514.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    12. Alternative luminal activation mechanisms for paneth cell α-defensins. J Biol Chem. 2012 Mar 30; 287(14):11205-12. Mastroianni JR, Costales JK, Zaksheske J, Selsted ME, Salzman NH, Ouellette AJ. PMID: 22334698; PMCID: PMC3322892.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    13. Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities. J Leukoc Biol. 2011 Feb; 89(2):283-90. Tongaonkar P, Tran P, Roberts K, Schaal J, Osapay G, Tran D, Ouellette AJ, Selsted ME. PMID: 21084627; PMCID: PMC3024902.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    14. SDF2L1, a component of the endoplasmic reticulum chaperone complex, differentially interacts with {alpha}-, {beta}-, and {theta}-defensin propeptides. J Biol Chem. 2009 Feb 27; 284(9):5602-9. Tongaonkar P, Selsted ME. PMID: 19109254; PMCID: PMC2645818.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    15. The cell-penetrating peptide, Pep-1, has activity against intracellular chlamydial growth but not extracellular forms of Chlamydia trachomatis. J Antimicrob Chemother. 2009 Jan; 63(1):115-23. Park N, Yamanaka K, Tran D, Chandrangsu P, Akers JC, de Leon JC, Morrissette NS, Selsted ME, Tan M. PMID: 18957395; PMCID: PMC2721699.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque. J Biol Chem. 2008 Dec 19; 283(51):35869-77. Vasudevan S, Yuan J, Osapay G, Tran P, Tai K, Liang W, Kumar V, Selsted ME, Cocco MJ. PMID: 18930922; PMCID: PMC2602889.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes. Infect Immun. 2008 Dec; 76(12):5883-91. Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME. PMID: 18852242; PMCID: PMC2583559.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    18. Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrob Agents Chemother. 2008 Mar; 52(3):944-53. Tran D, Tran P, Roberts K, Osapay G, Schaal J, Ouellette A, Selsted ME. PMID: 18160518; PMCID: PMC2258523.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    19. A pocket guide to explorations of the defensin field. Curr Pharm Des. 2007; 13(30):3061-4. Selsted ME. PMID: 17979748.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    20. Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties. J Immunol. 2006 Jan 15; 176(2):1154-62. Tydell CC, Yuan J, Tran P, Selsted ME. PMID: 16394004.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    21. Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005 Jun; 6(6):551-7. Selsted ME, Ouellette AJ, Ouellette AJ. PMID: 15908936.
      View in: PubMed   Mentions: 381     Fields:    Translation:HumansAnimalsCells
    22. Theta-defensins: cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins. Curr Protein Pept Sci. 2004 Oct; 5(5):365-71. Selsted ME. PMID: 15544531.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    23. Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004 Mar; 72(3):1470-8. Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted ME, Ouellette AJ, Ouellette AJ. PMID: 14977952; PMCID: PMC356057.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    24. Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. J Biol Chem. 2004 Mar 19; 279(12):11976-83. Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, Ouellette AJ, Ouellette AJ. PMID: 14702345.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    25. Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes. J Leukoc Biol. 2004 Feb; 75(2):332-41. Yamamoto CM, Banaiee N, Yount NY, Patel B, Selsted ME. PMID: 14634060.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    26. Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides. 2003 Nov; 24(11):1795-805. Satchell DP, Sheynis T, Kolusheva S, Cummings J, Vanderlick TK, Jelinek R, Selsted ME, Ouellette AJ, Ouellette AJ. PMID: 15019212.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    27. Antimicrobial peptides from human platelets. Infect Immun. 2002 Dec; 70(12):6524-33. Tang YQ, Yeaman MR, Selsted ME. PMID: 12438321; PMCID: PMC132966.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    28. Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells. Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G757-65. Yue G, Merlin D, Selsted ME, Lencer WI, Madara JL, Eaton DC. PMID: 11960772.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    29. Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding protein. A microbicidal granule protein of eosinophils and neutrophils. J Biol Chem. 2002 May 31; 277(22):19658-64. Tydell CC, Yount N, Tran D, Yuan J, Selsted ME. PMID: 11880375.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    30. Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. J Biol Chem. 2002 Feb 01; 277(5):3079-84. Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME. PMID: 11675394.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
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