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Andrade, Rosa M

TitleAssistant Professor
InstitutionUniversity of California, Irvine
DepartmentMedicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6320
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    Collapse Research 
    Collapse Research Activities and Funding
    Thio-dependent Antioxidants: A Novel Drug Target for Toxoplasma Gondii
    NIH/NIAID K08AI102989May 15, 2014 - Apr 30, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chaparro JD, Cheng T, Tran UP, Andrade RM, Brenner SBT, Hwang G, Cohn S, Hirata K, McKerrow JH, Reed SL. Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis. PLoS One. 2018; 13(3):e0193982. PMID: 29565998.
      View in: PubMed
    2. Andrade RM, Reed SL. New drug target in protozoan parasites: the role of thioredoxin reductase. Front Microbiol. 2015; 6:975. PMID: 26483758; PMCID: PMC4588103.
    3. Andrade RM, Chaparro JD, Capparelli E, Reed SL. Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis. PLoS Negl Trop Dis. 2014; 8(7):e2973. PMID: 25079790; PMCID: PMC4117455.
    4. Andrade RM, Torriani FJ, Ellis RJ. Acute HIV infection presenting as fulminant meningoencephalitis with massive CSF viral replication. Neurol Clin Pract. 2014 Jun; 4(3):256-259. PMID: 25110623.
      View in: PubMed
    5. Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med. 2012 Jun; 18(6):956-60. PMID: 22610278; PMCID: PMC3411919.
    6. Van Grol J, Subauste C, Andrade RM, Fujinaga K, Nelson J, Subauste CS. HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3. PLoS One. 2010 Jul 22; 5(7):e11733. PMID: 20661303; PMCID: PMC2908694.
    7. Subauste CS, Andrade RM, Wessendarp M. CD40-TRAF6 and autophagy-dependent anti-microbial activity in macrophages. Autophagy. 2007 May-Jun; 3(3):245-8. PMID: 17224624.
      View in: PubMed
    8. Fernández M, Alarcón GS, Apte M, Andrade RM, Vilá LM, Reveille JD. Systemic lupus erythematosus in a multiethnic US cohort: XLIII. The significance of thrombocytopenia as a prognostic factor. Arthritis Rheum. 2007 Feb; 56(2):614-21. PMID: 17265496.
      View in: PubMed
    9. Andrade RM, Alarcón GS, Fernández M, Apte M, Vilá LM, Reveille JD. Accelerated damage accrual among men with systemic lupus erythematosus: XLIV. Results from a multiethnic US cohort. Arthritis Rheum. 2007 Feb; 56(2):622-30. PMID: 17265497.
      View in: PubMed
    10. Andrade RM, Wessendarp M, Gubbels MJ, Striepen B, Subauste CS. CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J Clin Invest. 2006 Sep; 116(9):2366-77. PMID: 16955139; PMCID: PMC1555650.
    11. Andrade RM, Wessendarp M, Portillo JA, Yang JQ, Gomez FJ, Durbin JE, Bishop GA, Subauste CS. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J Immunol. 2005 Nov 01; 175(9):6014-21. PMID: 16237096.
      View in: PubMed
    12. Andrade RM, Portillo JA, Wessendarp M, Subauste CS. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun. 2005 May; 73(5):3115-23. PMID: 15845519; PMCID: PMC1087328.
    13. Subauste CS, Wessendarp M, Portilllo JA, Andrade RM, Hinds LM, Gomez FJ, Smulian AG, Grubbs PA, Haglund LA. Pathogen-specific induction of CD154 is impaired in CD4+ T cells from human immunodeficiency virus-infected patients. J Infect Dis. 2004 Jan 01; 189(1):61-70. PMID: 14702154.
      View in: PubMed
    14. Andrade RM, Wessendarp M, Subauste CS. CD154 activates macrophage antimicrobial activity in the absence of IFN-gamma through a TNF-alpha-dependent mechanism. J Immunol. 2003 Dec 15; 171(12):6750-6. PMID: 14662879.
      View in: PubMed