Rosa M Andrade

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6320
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    Thio-dependent Antioxidants: A Novel Drug Target for Toxoplasma Gondii
    NIH K08AI102989May 15, 2014 - Apr 30, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chagas Disease Diagnostic Practices at Four Major Hospital Systems in California and Texas. J Infect Dis. 2024 Jan 12; 229(1):198-202. Kelly EA, Echeverri Alegre JI, Promer K, Hayon J, Iordanov R, Rangwalla K, Zhang JJ, Fang Z, Huang C, Bittencourt CE, Reed S, Andrade RM, Bern C, Clark EH, Whitman JD. PMID: 37853514.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Gold(I) ion and the phosphine ligand are necessary for the anti-Toxoplasma gondii activity of auranofin. Microbiol Spectr. 2024 Jan 11; e0296823. Ma CI, Tirtorahardjo JA, Schweizer SS, Zhang J, Fang Z, Xing L, Xu M, Herman DA, Kleinman MT, McCullough BS, Barrios AM, Andrade RM. PMID: 38206030.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Auranofin Resistance in Toxoplasma gondii Decreases the Accumulation of Reactive Oxygen Species but Does Not Target Parasite Thioredoxin Reductase. Front Cell Infect Microbiol. 2021; 11:618994. Ma CI, Tirtorahardjo JA, Jan S, Schweizer SS, Rosario SAC, Du Y, Zhang JJ, Morrissette NS, Andrade RM. PMID: 33816332; PMCID: PMC8017268.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    4. Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis. PLoS One. 2018; 13(3):e0193982. Chaparro JD, Cheng T, Tran UP, Andrade RM, Brenner SBT, Hwang G, Cohn S, Hirata K, McKerrow JH, Reed SL. PMID: 29565998; PMCID: PMC5863946.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    5. New drug target in protozoan parasites: the role of thioredoxin reductase. Front Microbiol. 2015; 6:975. Andrade RM, Reed SL. PMID: 26483758; PMCID: PMC4588103.
      View in: PubMed   Mentions: 27  
    6. Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis. PLoS Negl Trop Dis. 2014; 8(7):e2973. Andrade RM, Chaparro JD, Capparelli E, Reed SL. PMID: 25079790; PMCID: PMC4117455.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    7. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med. 2012 Jun; 18(6):956-60. Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. PMID: 22610278; PMCID: PMC3411919.
      View in: PubMed   Mentions: 151     Fields:    Translation:Animals
    8. CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J Clin Invest. 2006 Sep; 116(9):2366-77. Andrade RM, Wessendarp M, Gubbels MJ, Striepen B, Subauste CS. PMID: 16955139; PMCID: PMC1555650.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimalsCells
    9. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun. 2005 May; 73(5):3115-23. Andrade RM, Portillo JA, Wessendarp M, Subauste CS. PMID: 15845519; PMCID: PMC1087328.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    10. Pathogen-specific induction of CD154 is impaired in CD4+ T cells from human immunodeficiency virus-infected patients. J Infect Dis. 2004 Jan 01; 189(1):61-70. Subauste CS, Wessendarp M, Portilllo JA, Andrade RM, Hinds LM, Gomez FJ, Smulian AG, Grubbs PA, Haglund LA. PMID: 14702154.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
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